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F13A1 Gene

protein-coding GIFtS: 65

GC06M006089

coagulation factor XIII, A1 polypeptide
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
(Previous symbol: F13A)

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
About This Section

Aliases
EC 2.3.2.13 ^³
F13A ^², ³, ⁵
TGase ^²
fibrinoligase ^²

Descriptions
Coagulation factor XIIIa ^³
FSF, A subunit ^²
Protein-glutamine gamma-glutamyltransferase A chain ^², ³
Transglutaminase A chain ^³
bA525O21.1 (coagulation factor XIII, A1 polypeptide) ^²
coagulation factor XIII A1 subunit ^²
coagulation factor XIII, A polypeptide ^²
coagulation factor XIII, A1 polypeptide ^²
factor XIIIa ^²
fibrin stabilizing factor, A subunit ^²
transglutaminase. plasma ^²

External Ids
HGNC: 3531¹
Entrez Gene: 2162²
UniProtKB: P00488³
Ensembl: ENSG00000124491⁷

Search outside databases for aliases for F13A1 gene

Previous GC identifer: GC06M006129

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

EntrezGene summary for F13A1:

This gene encodes the coagulation factor XIII A subunit. Coagulation factor XIII is the last

zymogen to become activated in the blood coagulation cascade. Plasma factor XIII is a

heterotetramer composed of 2 A subunits and 2 B subunits. The A subunits have catalytic function,

and the B subunits do not have enzymatic activity and may serve as plasma carrier molecules.

Platelet factor XIII is comprised only of 2 A subunits, which are identical to those of plasma

origin. Upon cleavage of the activation peptide by thrombin and in the presence of calcium ion,

the plasma factor XIII dissociates its B subunits and yields the same active enzyme, factor XIIIa,

as platelet factor XIII. This enzyme acts as a transglutaminase to catalyze the formation of

gamma-glutamyl-epsilon-lysine crosslinking between fibrin molecules, thus stabilizing the fibrin

clot. It also crosslinks alpha-2-plasmin inhibitor, or fibronectin, to the alpha chains of fibrin.

Factor XIII deficiency is classified into two categories: type I deficiency, characterized by the

lack of both the A and B subunits; and type II deficiency, characterized by the lack of the A

subunit alone. These defects can result in a lifelong bleeding tendency, defective wound healing,

and habitual abortion. [provided by RefSeq]

UniProtKB/Swiss-Prot: F13A_HUMAN, P00488

Function: Factor XIII is activated by thrombin and calcium ion to a transglutaminase that catalyzes

the formation of gamma-glutamyl-epsilon-lysine cross-links between fibrin chains, thus stabilizing

the fibrin clot. Also cross-link alpha-2-plasmin inhibitor, or fibronectin, to the alpha chains of

fibrin

Gene Wiki entry for F13A1 (Coagulation_factor_XIII%2C_A1_polypeptide)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the F13A1 gene

Entrez Gene cytogenetic band: 6p25.3-p24.3 Ensembl cytogenetic band: 6p25.1 HGNC cytogenetic band: 6p24.2-p23

F13A1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 6 GeneLoc Exon Structure

GeneLoc location for GC06M006089: (about GC identifiers)

Start:	6,089,310 bp from pter
End:	6,265,923 bp from pter
Size:	176,614 bases
Orientation:	minus strand

RefSeq DNA sequence:

NC_000006.10 NT_034880.3

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
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UniProtKB/Swiss-Prot: F13A_HUMAN, P00488 (See protein sequence)

Recommended Name: Coagulation factor XIII A chain precursor

Size: 732 amino acids; 83267 Da

Cofactor: Binds 1 calcium ion per subunit

Subunit: Tetramer of two A chains and two B chains

Subcellular location: Cytoplasm. Secreted. Note=Secreted into the blood plasma. Cytoplasmic in most

tissues, but also secreted in the blood plasma

PDB structures from and Proteopedia :

1EVU (3D)

1EX0 (3D)

1F13 (3D)

1FIE (3D)

1GGT (3D)

1GGU (3D)

1GGY (3D)

1QRK (3D)

Secondary accessions: Q59HA7 Q8N6X2 Q96P24

Post-translational modifications:

The activation peptide is released by thrombin¹

View phosphorylation sites using PhosphoSite²

REFSEQ proteins: NP_000120.2

ENSEMBL proteins:

ENSP00000369294 ENSP00000264870

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Browse Purified and Recombinant Proteins at Millipore
	Sigma-Aldrich Proteins for F13A1
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Recombinant Proteins from Abcam (Factor XIII/XIIIa, Factor XIIIa)
	Human Recombinant Proteins from Abnova (F13A1)

Browse Origene for full length recombinant human proteins expressed in human HEK293 cells

2 Gene Ontology (GO) cellular component terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005576	extracellular region	TAS	2877457
GO:0005737	cytoplasm	IEA	--

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Antibodies for F13A1:

	Browse Antibodies Central at Invitrogen
	Millipore Mono- and Polyclonal Antibodies for the study of F13A1
	Sigma-Aldrich Antibodies for F13A1
	Browse R&D Systems for Antibodies
	Antibodies from Abcam (Factor XIII/XIIIa, Factor XIIIa), each with their Abpromise^SM
	Monoclonal and Polyclonal Antibodies from Abnova (F13A1)
	Novus Biologicals Antibodies for F13A1

Assays for F13A1:

	Browse Invitrogen for biochemical assays
	Browse Kits and Assays available from Millipore
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

Graphical View of Domain Structure for InterPro Entry P00488

ProtoNet protein and cluster: P00488

1 Blocks protein family: IPB002931 Transglutaminase-like domain

UniProtKB/Swiss-Prot: F13A_HUMAN, P00488

Similarity: Belongs to the transglutaminase superfamily. Transglutaminase family

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (F13A1)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (F13A1)

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_000129

Applied Biosystems Silencer® siRNAs for F13A1

Sigma-Aldrich siRNA and siRNA Panels for F13A1

Sigma-Aldrich shRNA Panels and shRNA for F13A1

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Invitrogen Clones for F13A1
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clone in CMV expression vector: NM_000129
Myc/DDK tagged cDNA clone in CMV expression vector: NM_000129
untagged cDNA clone in CMV expression vector: NM_000129

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_000129

UniProtKB/Swiss-Prot: F13A_HUMAN, P00488

Function: Factor XIII is activated by thrombin and calcium ion to a transglutaminase that catalyzes

the formation of gamma-glutamyl-epsilon-lysine cross-links between fibrin chains, thus stabilizing

the fibrin clot. Also cross-link alpha-2-plasmin inhibitor, or fibronectin, to the alpha chains of

fibrin

Catalytic activity: Protein glutamine + alkylamine = protein N(5)-alkylglutamine + NH(3)

Enzyme Number (IUBMB): EC 2.3.2.13

Genatlas biochemistry entry for F13A1:

coagulation factor XIII,A1 polypeptide,catalytic subunit (75kDa),catalyzing the formation of

glutamyl-lysine bonds between fibrin monomers

6 MGI mutant phenotypes (inferred from 1 allele) (MGI details for F13a1):

	hematopoietic system	homeostasis/metabolism	life span-post-weaning/aging	reproductive system
respiratory system

4 Gene Ontology (GO) molecular function terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0003810	protein-glutamine gamma-glutamyltransferase activity	TAS	2877456
GO:0005509	calcium ion binding	IEA	--
GO:0008415	acyltransferase activity	IEA	--
GO:0016740	transferase activity	IEA	--

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

1 Sigma-Aldrich "Your Favorite Gene" Pathway for F13A1 (Your Favorite Gene powered by Ingenuity)

Coagulation System

GeneDecks F13A1 for the pathways selected above

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Gene Network Central^TM Interacting Genes and Proteins Network for F13A1

5/18 Interacting proteins for F13A1 (ENSP00000264870³) via UniProtKB, MINT, and/or STRING (see all 18 )

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
F13B	ENSP00000356382³	STRING (score=.998)
FGA	ENSP00000306361³	STRING (score=.988)
FGG	ENSP00000336829³	STRING (score=.982)
FGB	ENSP00000306099³	STRING (score=.95)
F10	ENSP00000364709³	STRING (score=.912)

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2 Gene Ontology (GO) biological process terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0007596	blood coagulation	TAS	10801785
GO:0018149	peptide cross-linking	IEA	--

About this table

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences

Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for F13A1
10/19 Novoseek chemical compound relationships for F13A1 gene (see all 19 )

Compound	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
fibrinogen	74.70	78	1685332 (3), 10631982 (3), 19198072 (3), 9710118 (2) (see all 52)
epsilon-(gamma-glutamyl)lysine	71.08	3	9465033 (1), 11460466 (1), 9724734 (1)
reticulin	51.80	1	1505929 (1)
s 100	48.66	2	1281618 (1), 11285404 (1)
amine	42.48	6	1352131 (1), 10799541 (1), 1978326 (1), 16636049 (1) (see all 6)
hematoxylin	28.41	3	7512798 (1), 10366399 (1), 15803191 (1)
b 723	28.04	4	7521638 (2), 12514785 (2)
lysine	22.39	5	15837518 (1), 11460477 (1), 19257897 (1), 9603949 (1)
calcium	4.02	4	2059625 (1), 9295325 (1)
procollagen	3.86	2	7510487 (1), 7538779 (1)

About this table

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (F13A1)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (F13A1)

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_000129

Sigma-Aldrich siRNA and siRNA Panels for F13A1

Sigma-Aldrich shRNA Panels and shRNA for F13A1

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_000129

REFSEQ mRNAs for F13A1 gene:

NM_000129.3

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_000129

              OriGene GFP tagged cDNA clone in CMV expression vector: NM_000129
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_000129
                                 untagged cDNA clone in CMV expression vector: NM_000129

Additional cDNA sequence:

AB208852.1 AK130666.1 AK304335.1 AK312735.1 BC027963.1 CR597673.1 CR612572.1 CR620128.1

M14354.1 M14539.1

8 DOTS entries:

DT.453281 DT.100797643 DT.101979204 DT.100702451 DT.121317831 DT.91696727 DT.95370037 DT.121317847

24/268 AceView cDNA sequences (see all 268 ):

AI539311 AU120508 BU078830 BX361381 BX361150 BI765332 BX403516 AW026260

AL542145 CR612572 AI084428 AI096407 BQ181975 BM973214 BX402510 AA025425

BC027963 BQ447657 AL541304 AI146398 AA317726 R80205 BP367341 AA235945

highest scoring ESTs for F13A1:

M14539 AL541304 AL542145 BC027963 BI837840 BM921756 BX340175 BX345635 BX361150 BX361381

Unigene Cluster for F13A1:

Coagulation factor XIII, A1 polypeptide

Hs.335513 [show with all ESTs]

Unigene Representative Sequence: BC027963

GeneLoc Exon Structure

2 Ensembl transcripts including schematic representations:

ENST00000379960 ENST00000264870

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

F13A1 expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for F13A1

¹ / ² / ³

3 probe-sets matching F13A1 gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
38052_at²^{, 3}	U95-A	1	1.00	1.00	1.00	1.00	M14539	1.00	1.00	1.00	1
203305_at²^{, 3}	U133-A	1	1.00	1.00	--	--	NM_000129	0.60	1.00	0.82	1
203305_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--

GeneDecks F13A1 for binary patterns associated with the probe-sets selected above

About GeneDecksing

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Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: TTGAGACCTC

SOURCE GeneReport for Unigene cluster: Hs.335513
Expression variation in blood from EXPOLDB for F13A1

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for F13A1 gene from 5/9 species (see all 9 )

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	F13A1¹	--	coagulation factor XIII, A1 polypeptide	87.73(n) 88.1(a)	478711 XM_535876.2 XP_535876.2
chimpanzee (Pan troglodytes)	F13A1¹	--	coagulation factor XIII, A1 polypeptide	99.45(n) 99.45(a)	462413 XM_518220.2 XP_518220.2
cow (Bos taurus)	F13A1¹	--	coagulation factor XIII, A1 polypeptide	84.74(n) 86.75(a)	617881 XM_588122.3 XP_588122.3
rat (Rattus norvegicus)	F13a1¹	--	coagulation factor XIII, A1 polypeptide	84.24(n) 84.29(a)	60327 NM_021698.1 NP_067730.1
mouse (Mus musculus)	F13a1^{1, 5}	13⁵	coagulation factor XIII, A1 subunit^{1, 5}	84.65(n)¹ 86.89(a)¹	74145¹ NM_028784.2¹ NP_083060.2¹ AA823048⁵ AI462306⁵ (see all 17)

About this table Species with no ortholog for F13A1

ENSEMBL Gene Tree for F13A1

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

Paralogs for F13A1 gene

TGM3² TGM1² TGM4² TGM6²

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

UniProtKB/Swiss-Prot: F13A_HUMAN, P00488

Polymorphism: There are four main allelic forms of this protein; F13A*1A, F13A*1B, F13A*2A and

F13A*2B. In addition two other intermediate forms (F13A*(2)A and F13A*(2)B) seem to exist. The

sequence shown is that of F13A*(2)B

10/1332 NCBI SNPs in F13A1 are shown (see all 1332 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 550)

AB	SNP ID	Valid	Chr 6 pos	Sequence	Recs	AA Chg	Type	More	Recs	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--			--
	rs9504688^1,2	A,C,F,H	6088943(+)	`TGATTA/GTCATA`	1	--	ng5¹		4	EU EA WA	406
	rs3024305^1,2	A,C,F,H	6267818(-)	`AGCCTC/GAAGAA`	1	--	ng3¹		16	NS EU EA WA	1596
--	rs5985^1,2	A,C,F,H	6263794(-)	`AGGGCG/TTGGTG`	1	V/L	mis¹		14	MN NS EU EA WA	1392
	rs3024304^1,2	A,C,F,H	6267874(-)	`GATAGA/CAAATA`	1	--	ng3¹		10	NS EU EA WA	926
	rs1050782^1,2	A,C,F,H	6090725(-)	`AGGGCT/CCCAGA`	1	--	ut3¹ ese³		14	EA NS NA EU WA	2512
	rs9502421^1,2	A,C,F,H	6088960(+)	`TAACAT/GGTGTT`	1	--	ng5¹		2	EA	174
	rs5982^1,2	A,C,F,H	6119865(-)	`GGTCCC/TGAAGG`	1	P/L	mis¹ ese³		23	MN NS EA NA EU WA	2138
	rs3024466^1,2	A,C,F,H	6089856(-)	`CCCATG/TTTGAG`	1	--	ut3¹ ese³		12	NS EU EA WA	1168
	rs3024486^1,2	C,F,H	6090408(-)	`TTCTCG/AGGGTC`	1	--	ut3¹ ese³		15	NS NA EU EA WA	1312
	rs12862^1,2	C,F,H	6090108(-)	`AGCAGG/AAGCCA`	1	--	ut3¹ ese³		16	NS MN EU EA WA NA	1496

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HapMap Linkage Disequilibrium images for F13A1 (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

OMIM: 134570

UniProtKB/Swiss-Prot: F13A_HUMAN, P00488

Defects in F13A1 are the cause of F13A deficiency [MIM:134570]. F13A deficiency is an

autosomal recessive disorder characterized by a life-long bleeding tendency, impaired wound

healing and spontaneous abortion in affected women. In addition to the common presentation such as

subcutaneous and intramuscular haematomas, severe bleeding such as intracranial hemorrhages may

occur

10/68 Novoseek disease relationships for F13A1 gene (see all 68 )

Disease	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
dermatofibroma	92.82	26	16640542 (2), 16740036 (2), 7545142 (2), 7694515 (1) (see all 23)
juvenile xanthogranuloma	85.94	3	7511867 (1), 10871066 (1), 15630537 (1)
dermatofibrosarcoma protuberans	85.88	12	16640542 (2), 16740036 (2), 7694515 (1), 11401666 (1) (see all 10)
histiocytoma fibrous	81.97	7	16640542 (2), 11401666 (1), 1972317 (1), 9185909 (1) (see all 5)
factor xiii deficiency	72.85	2	14720426 (1), 12801297 (1)
xanthoma disseminatum	70.51	3	1519935 (2)
fibroma	67.53	4	7523665 (2), 11401666 (1)
dysfibrinogenemia	63.95	1	10443961 (1)
hemangiopericytoma	62.52	1	9561329 (1)
angiofibroma	54.51	3	8733380 (1), 7523665 (1), 14744088 (1)

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Genatlas disease: F13A1

bleeding tendency,defective wound healing,habitual abortion,fibrin-stabilizing factor

deficiency,type II

Human Gene Mutation Database: F13A1
Genetic Association Database: F13A1
Human Genome Epidemiology Navigator: F13A1 (103 documents)

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
About This Section

10/513 PubMed articles for F13A1 gene (see all 513 ):

Preeclampsia and its interaction with common variants in thrombophilia genes. (PubMed id 15333035)^{1, 3, 6} De Maat M.P....De Groot C.J. (2004)
Coagulation factor XIII polymorphisms and the risk of myocardial infarction and ischaemic stroke in young women. (PubMed id 11841441)^{1, 3, 6} Reiner A.P....Siscovick D.S. (2002)
Identification of a point mutation in factor XIII A subunit deficiency. (PubMed id 1353995)^{1, 3, 4} Board P.... Miloszewski K. (1992)
Parent-of-origin transmission of thrombophilic alleles to intrauterine growth-restricted newborns and transmission-ratio distortion in unaffected newborns. (PubMed id 16192348)^{3, 6} Infante-Rivard C. and Weinberg C.R. (2005)
Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry. (PubMed id 16335952)^{3, 4} Liu T.... Smith R.D. (2005)
Polymorphisms of haemostasis genes as risk factors for preterm delivery. (PubMed id 16113789)^{3, 6} Hartel C....Gopel W. (2005)
Turkish population data on the factor XIII Val34Leu,glycoprotein (GP)Ibalpha Kozak and P-selectin glycoprotein ligand 1 (PSGL-1) loci. (PubMed id 15386532)^{3, 6} Hancer V.S....Nalcaci M. (2005)
A pharmacogenetic effect of factor XIII valine 34 leucine polymorphism on fibrinolytic therapy for acute myocardial infarction. (PubMed id 15629368)^{3, 6} Marin F....Vicente V. (2005)
Factor XIII Val34Leu polymorphism and gamma-chain cross-linking at the site of microvascular injury in healthy and coumadin-treated subjects. (PubMed id 16102108)^{3, 6} Undas A....Mann K.G. (2005)
Polymorphisms in prothrombotic genes and their impact on ischemic stroke in a Sardinian population. (PubMed id 15968394)^{3, 6} Rubattu S....Volpe M. (2005)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
About This Section

Entrez Gene: 2162	HGNC: 3531	AceView: F13A1	Ensembl:ENSG00000124491	euGenes: HUgn2162
ECgene: F13A1	H-InvDB: F13A1

(According to HUGE)
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(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
GeneReviews	http://www.genetests.org/query?gene=F13A1
SeattleSNPs	http://pga.gs.washington.edu/data/f13a1/
SHMPD	http://shmpd.bii.a-star.edu.sg/gene.php?genestart=A&genename=F13A1
Wikipedia	http://en.wikipedia.org/wiki/Factor_XIII

Licensable Technologies for F13A1
(Available from WIS Yeda, Salk, Tufts)

About This Section

(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section

Products for F13A1:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for F13A1-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for F13A1		Antibodies for F13A1
	Explore super-pooled esiRNAs		Proteins for F13A1
	Lentivirus-delivered shRNAs for F13A1		Browse small molecules at Sigma-Aldrich
	"Your Favorite Gene" Pathways		feedback

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	Cell Culture Products		ELISAs
	Flow Cytometry Kits		Protease Activity Assays & Reagents
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	Multiplex/Array Assay Kits & Reagents		ELISpot Kits & Development Modules
	Recombinant & Natural Proteins

	Recombinant Proteins (F13A1)
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	Chimera RNAi (F13A1)
	Custom Service for Mouse Mab
	Custom Service for Rabbit Pab from Full-length Protein

Search for Antibodies & Assays

	Recombinant Proteins (Factor XIII/XIIIa, Factor XIIIa)
	Antibodies (Factor XIII/XIIIa, Factor XIIIa)

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Search www.enzolifesicences.com for proteins, assays, substrates, inhibitors & antibodies

Antibodies for F13A1

GeneCards Homepage - Last full update: 2 Jul 2009 Incremental update: 13 Oct 2009

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about GIFtS

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Developed at the Crown Human Genome Center & Weizmann Institute of Science

The GeneCards Human Gene Database: Copyright © 1996-2009, Weizmann Institute of Science. All Rights Reserved.
F13A1 Gene at Home site.
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F13A1 Gene

protein-coding GIFtS: 65

Aliases &
Descriptions
for F13A1

Summaries
for F13A1

Genomic Location
for F13A1

Proteins
for F13A1

Protein Domains/
Families
for F13A1

Gene Function
for F13A1

Pathways & Interactions
for F13A1

Drugs & Compounds
for F13A1

Transcripts
for F13A1

Expression
for F13A1

Orthologs
for F13A1

Paralogs
for F13A1

SNPs/Variants
for F13A1

Disorders & Mutations
for F13A1

Medical News
for F13A1

Publications
for F13A1

Search for F13A1

Genome Databases showing F13A1

Other Databases showing F13A1

Specialized Databases showing F13A1

Licensable Technologies
for F13A1

Services
for F13A1

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

F13A1 Gene

protein-coding GIFtS: 65

Aliases & Descriptionsfor F13A1

Summariesfor F13A1

Genomic Locationfor F13A1

Proteinsfor F13A1

Protein Domains/Familiesfor F13A1

Gene Functionfor F13A1

Pathways & Interactionsfor F13A1

Drugs & Compoundsfor F13A1

Transcriptsfor F13A1

Expression for F13A1

Orthologsfor F13A1

Paralogsfor F13A1

SNPs/Variantsfor F13A1

Disorders & Mutationsfor F13A1

Medical Newsfor F13A1

Publicationsfor F13A1

Search for F13A1

Genome Databases showing F13A1

Other Databases showing F13A1

Specialized Databases showing F13A1

Licensable Technologiesfor F13A1

Servicesfor F13A1

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for F13A1

Summaries
for F13A1

Genomic Location
for F13A1

Proteins
for F13A1

Protein Domains/
Families
for F13A1

Gene Function
for F13A1

Pathways & Interactions
for F13A1

Drugs & Compounds
for F13A1

Transcripts
for F13A1

Expression
for F13A1

Orthologs
for F13A1

Paralogs
for F13A1

SNPs/Variants
for F13A1

Disorders & Mutations
for F13A1

Medical News
for F13A1

Publications
for F13A1

Licensable Technologies
for F13A1

Services
for F13A1