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F12 Gene

protein-coding   GIFtS: 63

GC05M176761
coagulation factor XII (Hageman factor)
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
Services    

Aliases &
Descriptions
for F12

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc , and/or 7Ensembl, 8miRBase)
About This Section
Aliases
EC 3.4.21.38 3
HAE3 2, 5
HAEX 2
HAF 2, 3, 5
Descriptions
Hageman factor 2, 3
beta-factor XIIa part 1 2
beta-factor XIIa part 2 2
coagulation factor XII 2
coagulation factor XII (Hageman factor) 2
coagulation factor XIIa heavy chain 2
coagulation factor XIIa light chain 2
External Ids
HGNC: 35301
Entrez Gene: 21612
UniProtKB: P007483
Ensembl: ENSG000001311877
Search outside databases for aliases for F12 gene

Previous GC identifers: GC05M177202 GC05M177671 GC05M176764 GC05M176810

Summaries
for F12

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

 EntrezGene summary for F12:
This gene encodes coagulation factor XII which circulates in blood as a zymogen. This single chain
zymogen is converted to a two-chain serine protease with an heavy chain (alpha-factor XIIa) and a
light chain. The heavy chain contains two fibronectin-type domains, two epidermal growth factor
(EGF)-like domains, a kringle domain and a proline-rich domain, whereas the light chain contains
only a catalytic domain. On activation, further cleavages takes place in the heavy chain,
resulting in the production of beta-factor XIIa light chain and the alpha-factor XIIa light chain
becomes beta-factor XIIa heavy chain. Prekallikrein is cleaved by factor XII to form kallikrein,
which then cleaves factor XII first to alpha-factor XIIa and then to beta-factor XIIa. The active
factor XIIa participates in the initiation of blood coagulation, fibrinolysis, and the generation
of bradykinin and angiotensin. It activates coagulation factors VII and XI. Defects in this gene
do not cause any clinical symptoms and the sole effect is that whole-blood clotting time is
prolonged. [provided by RefSeq]

UniProtKB/Swiss-Prot: FA12_HUMAN, P00748
Function: Factor XII is a serum glycoprotein that participates in the initiation of blood
coagulation, fibrinolysis, and the generation of bradykinin and angiotensin. Prekallikrein is
cleaved by factor XII to form kallikrein, which then cleaves factor XII first to alpha-factor XIIa
and then to beta-factor XIIa. Alpha-factor XIIa activates factor XI to factor XIa

Gene Wiki entry for F12 (Factor_XII)

Genomic Location
for F12

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

 Genomic View:
UCSC Golden Path with GeneCards custom track

 Transcription factor binding sites upstream to the F12 gene  

Entrez Gene cytogenetic band: 5q33-qter   Ensembl cytogenetic band:  5q35.3   HGNC cytogenetic band: 5q33-qter

F12 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 5         GeneLoc Exon Structure

GeneLoc location for GC05M176761:     (about GC identifiers)

Start:
 176,761,745 bp from pter
End:
 176,769,183 bp from pter
Size:
 7,439 bases
Orientation:
 minus strand
RefSeq DNA sequence:
NC_000005.8  NT_023133.12  

Proteins
for F12

(According to 1UniProtKB, and/or Ensembl, Phosphorylation sites according to 2Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
About This Section

 UniProtKB/Swiss-Prot: FA12_HUMAN, P00748 (See protein sequence)
Recommended Name: Coagulation factor XII precursor  
Size: 615 amino acids; 67818 Da
Subcellular location: Secreted
Secondary accessions: P78339

Post-translational modifications:

  • O- and N-glycosylated. The O-linked polysaccharides were not identified, but are probably the mucin
    type linked to GalNAc1


    • REFSEQ proteins: NP_000496.2  

    ENSEMBL proteins: 
    ENSP00000253496 


    Human Recombinant Proteins 
    Browse Drug Discovery Central at Invitrogen for human recombinant proteins
    Browse Purified and Recombinant Proteins at Millipore
    Browse Human Recombinant Proteins at Sigma-Aldrich  
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Recombinant Proteins from Abcam (Factor XII heavy chain cleaved Arg372, Factor XII light chain, Factor XII heavy chain, Factor XII)
    Human Recombinant Proteins from Abnova (F12)
                    Browse Origene for full length recombinant human proteins expressed in human HEK293 cells 

    2 Gene Ontology (GO) cellular component terms (links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576 extracellular region IEA--
    GO:0005615 extracellular space IEA--
    About this table

    Antibodies for F12: 
    Browse Antibodies Central at Invitrogen
    Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Sigma-Aldrich Antibodies for F12
    Browse R&D Systems for Antibodies
    Antibodies from Abcam (Factor XII heavy chain cleaved Arg372, Factor XII light chain, Factor XII heavy chain, Factor XII), each with their AbpromiseSM
    Monoclonal and Polyclonal Antibodies from Abnova (F12)
    Novus Biologicals Antibodies for F12

    Assays for F12: 
    Browse Invitrogen for biochemical assays
    Browse Kits and Assays available from Millipore
    Browse R&D Systems for biochemical assays
    Browse biochemical assays available from Enzo Life Sciences

    Protein Domains/
    Families
    for F12

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    5/13 InterPro domains/families (see all 13 ):
     IPR000083 Fibrnctn1
     IPR018059 Kringle_sub
     IPR001314 Peptidase_S1A
     IPR014394 Coagulation_fac_XII_Hep-GF-Act
     IPR000742 EGF_3


       GeneDecks  F12 for the domains selected above  
    About GeneDecksing

    Graphical View of Domain Structure for InterPro Entry P00748

    ProtoNet protein and cluster: P00748

    5/6 Blocks protein families (see all 6 ):
    IPB000001 Kringle
    IPB000083 Fibronectin
    IPB000562 Type II fibronectin collagen-binding domain
    IPB001254 Serine protease
    IPB001314 Chymotrypsin serine protease family (S1) signature


    UniProtKB/Swiss-Prot: FA12_HUMAN, P00748
    Similarity: Belongs to the peptidase S1 family
    Similarity: Contains 2 EGF-like domains
    Similarity: Contains 1 fibronectin type-I domain
    Similarity: Contains 1 fibronectin type-II domain
    Similarity: Contains 1 kringle domain
    Similarity: Contains 1 peptidase S1 domain

    Gene Function
    for F12

    (According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
    shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
    RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
    About This Section
    Inhib.
    RNA:    		Invitrogen RNAi Products for gene knock-down (F12)
    Browse for Gene Knock-down Tools from Millipore
    Abnova Chimera RNAi Products for Gene knock-down (F12)
                  OriGene 29mer shRNA kit in GFP-retroviral vector: NM_000505

                  Applied Biosystems Silencer® siRNAs for F12

                  Sigma-Aldrich siRNA and siRNA Panels for F12  
                         Sigma-Aldrich shRNA for F12  
                         Explore Sigma-Aldrich super-pooled esiRNAs  

    Clones:Invitrogen Clones for F12
    Browse Clones for the Expression of Recombinant Proteins Available from Millipore
                  OriGene GFP tagged cDNA clone in CMV expression vector: NM_000505
                                     Myc/DDK tagged cDNA clone in CMV expression vector: NM_000505
                                     untagged cDNA clone in CMV expression vector: NM_000505 

    Primers: Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers
                  OriGene genome-wide validated SYBR primer pairs: NM_000505

    UniProtKB/Swiss-Prot: FA12_HUMAN, P00748
    Function: Factor XII is a serum glycoprotein that participates in the initiation of blood
    coagulation, fibrinolysis, and the generation of bradykinin and angiotensin. Prekallikrein is
    cleaved by factor XII to form kallikrein, which then cleaves factor XII first to alpha-factor XIIa
    and then to beta-factor XIIa. Alpha-factor XIIa activates factor XI to factor XIa
    Catalytic activity: Selective cleavage of Arg- -Ile bonds in factor VII to form factor VIIa and
    factor XI to form factor XIa
    Enzyme Number (IUBMB): EC 3.4.21.38 

    Genatlas biochemistry entry for F12:
    coagulation factor XII,80kDa, (Hageman)

    3 MGI mutant phenotypes (inferred from 1 allele) (MGI details for F12):

    homeostasis/metabolismnervous systemnormal

    4 Gene Ontology (GO) molecular function terms (links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004252 serine-type endopeptidase activity IEA--
    GO:0005488 binding IDA8665943
    GO:0008233 peptidase activity IEA--
    GO:0051787 misfolded protein binding IC18725990
    About this table

    Pathways & Interactions
    for F12

    (Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
    Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to 1UniProtKB, 2MINT, and/or 3STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
    About This Section


    1 Millipore Pathway for F12
     Cell adhesion Plasmin signaling

       GeneDecks  F12 for the pathways selected above  
    About GeneDecksing

    2 Sigma-Aldrich "Your Favorite Gene" Pathways for  F12  (Your Favorite Gene powered by Ingenuity) 
     Coagulation System
     Lysine Degradation

       GeneDecks  F12 for the pathways selected above  
    About GeneDecksing

    1 Kegg Pathway  (Kegg details for F12):
     hsa04610 Complement and coagulation cascades

       GeneDecks  F12 for the pathways selected above  
    About GeneDecksing
     Gene Network CentralTM Interacting Genes and Proteins Network for  F12 

    5/10 Gene Ontology (GO) biological process terms (links to tree view) (see all 10 ):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0002542 Factor XII activation IDA18725990
    GO:0007597 blood coagulation, intrinsic pathway IC18725990
    GO:0010756 positive regulation of plasminogen activation IDA89876
    GO:0016540 protein autoprocessing IDA18725990
    GO:0030194 positive regulation of blood coagulation IDA6793628
    About this table

    Drugs & Compounds
    for F12

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
    About This Section

    Browse drugs & compounds from Enzo Life Sciences
    Browse Small Molecules at Sigma-Aldrich

    Browse Tocris compounds for F12
    4 Novoseek chemical compound relationships for F12 gene
    Compound   Score   Articles   PubMed IDs for Articles with Shared Sentences (# sentences)
    vitamin-e 4.75 1 10225721 (1)
    histidine 4.16 1 8447816 (1)
    zinc 0.86 1 7749371 (1)
    fibrinogen 0.00 3 14524034 (2), 11755949 (1)
    About this table


    Transcripts
    for F12

    (GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView,
    non coding RNAs according to RNAdb,
    ESTs according to GeneTide,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from Invitrogen, Millipore, and/or Abnova,
    siRNAs from Applied Biosystems, Sigma-Aldrich,
    shRNA from Sigma-Aldrich, OriGene,
    Tagged/untagged cDNA clones from OriGene,
    Expression Assays from Applied Biosystems)
    About This Section
    Inhib.
    RNA:    		Invitrogen RNAi Products for gene knock-down (F12)
    Browse for Gene Knock-down Tools from Millipore
    Abnova Chimera RNAi Products for Gene knock-down (F12)
                  OriGene 29mer shRNA kit in GFP-retroviral vector: NM_000505

                  Sigma-Aldrich siRNA and siRNA Panels for F12  
                         Sigma-Aldrich shRNA for F12  
                         Explore Sigma-Aldrich super-pooled esiRNAs  

    Applied Biosystems Silencer® siRNAs: 

    NM_000505  

    REFSEQ mRNAs for F12 gene: 

    NM_000505.3   

    Applied Biosystems TaqMan ® Gene Expression Assays: 

    NM_000505  

                  OriGene GFP tagged cDNA clone in CMV expression vector: NM_000505
                                     Myc/DDK tagged cDNA clone in CMV expression vector: NM_000505
                                     untagged cDNA clone in CMV expression vector: NM_000505 

    Additional cDNA sequence: 

    AB095845.1 BC012390.1 BT007350.1 CR601747.1 CR602253.1 CR616520.1 M11723.1 M13147.1 
    M31315.1 

    9 DOTS entries:

    DT.312633  DT.92424230  DT.95077161  DT.100755217  DT.100755218  DT.120810943  DT.92424226  DT.95263422 
    DT.92424234 

    24/78 AceView cDNA sequences (see all 78 ):

    BC012390 BG533735 BF530348 BQ276450 AW291360 BM563198 BM784735 CR601747 
    BG531824 BF513608 BM765106 AB095845 AL564533 BM745007 BG248482 BM995940 
    BX095486 BE796109 BM820716 BM826182 BM781626 CR602253 BX431924 CD608657 

    highest scoring ESTs for F12:

    M31315 AB095845 M11723 AA039335 AA052968 AA381115 AA447259 AI023410 AI984145 AL531940 

    Unigene Cluster for F12:

    Coagulation factor XII (Hageman factor)
    Hs.1321  [show with all ESTs]
    Unigene Representative Sequence: NM_000505


    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for F12

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8 ^ 9a · 9b ^ 10 ^ 11a · 11b · 11c ^ 12 ^ 13 ^ 14
    SP1:                                      -                 -                 -                                 
    SP2:                                                  -     -                 -                                 
    SP3:                                                                          -                                 
    SP4:                                                                                                            

    About this scheme

    ECgene alternative splicing isoforms for F12

    1 Ensembl transcript including schematic representation:
    ENST00000253496  

    Expression
    for F12

    (Experimental results according to 1GeneNote and GNF BioGPS,
    probe sets-to-genes annotations according to 2GeneAnnot , 3GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
    Expression Assays from Applied Biosystems )
    About This Section

    F12 expression in normal and diseased human tissues

     Applied Biosystems TaqMan ® Gene Expression Assays for F12

    1 / 2 / 3

    3 probe-sets matching F12 gene


    		Affymetrix
    probe-set    		 Array  GeneAnnot data GeneNote data GeneTide data
    # genes Sensitivity Specificity Correlation Length Gb_Accession Consensus Uniqueness Score Rank
    37838_at2, 3 U95-A 1 1.00 1.00 1.00 1.00 M31315 1.00 1.00 1.00 1

    		205774_at2, 3 U133-A 1 1.00 1.00 -- -- NM_000505 0.60 1.00 0.82 1

    		205774_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --
    GeneDecks  F12 for binary patterns associated with the probe-sets selected above  
    About GeneDecksing
    About this table    
    Data from (Publications) and GNF BioGPS
        About these images
    About these images

    CGAP SAGE TAG: GAAGGCAAGA

    SOURCE GeneReport for Unigene cluster: Hs.1321

    Expression variation in blood from EXPOLDB for F12

    Orthologs
    for F12

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD and/or 5MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
    About This Section
    Orthologs for F12 gene from 5 species
    Organism Gene Locus Description Human
    Similarity    		 NCBI accessions
    dog
    (Canis familiaris)    		 F121   -- coagulation factor XII (Hageman factor) 81.88(n)
    74.3(a)    		 489090  XM_546206.2  XP_546206.2 
    chimpanzee
    (Pan troglodytes)    		 F121   -- coagulation factor XII (Hageman factor) 99.4(n)
    98.86(a)    		 462304  XM_518130.2  XP_518130.2 
    rat
    (Rattus norvegicus)    		 F121   -- coagulation factor XII (Hageman factor) 77.54(n)
    73.38(a)    		 306761  NM_001014006.1  NP_001014028.1 
    mouse
    (Mus musculus)    		 F121, 5 135
    		 coagulation factor XII (Hageman factor)1, 5 77.44(n)1
    72.19(a)1    		 589921  NM_021489.11  NP_067464.11 
     AV0267325  AW1117335  (see all 10)
    fruit fly
    (Drosophila melanogaster)    		 EG:80H7.33 2A4 trypsin 40(a)
    (best of 4)    		   --
    About this table        Species with no ortholog for F12

    ENSEMBL Gene Tree for F12

    Paralogs
    for F12

    (Paralogs according to 1HomoloGene
    and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
    About This Section

    Paralogs for F12 gene
    HABP22  PLAU2  PLAT2  HGFAC2  

    SNPs/Variants
    for F12

    (According to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
    About This Section


    10/96 NCBI SNPs in F12 are shown (see all 96 )
    (Click for Applied Biosystems TaqMan ® Genotyping Assay)  (see all 44)
    ABGenomic DataTranscription DataAllele Frequencies
    SNP IDValidChr 5 posSequenceRecsAA
    Chg    		TypeMoreRecsAllele
    freq    		PopTotal
    sample    		More
    ------------
    rs13633521,2
    		A,C,F,H176770398(-) TCTCAT/GTAAAT 1 -- ng3115Minor allele frequency- G:0.06MN EU EA WA NS NA 1526
    rs18010201,2
    		C,F,H,O176769138(-) ACGGAC/TGCCAT 1 -- ut51 ese315Minor allele frequency- N:0.00EA NA NS EU WA 2636
    rs73811031,2
    		C,F,H176770918(+) cctcaC/Gcacct 1 -- ng314Minor allele frequency- G:0.15EU EA WA 420
    --
    rs22523171,2
    		A,C,F176770096(-) accccA/Ctctct 1 -- ng312Minor allele frequency- C:0.10NS 90
    --
    rs22523161,2
    		A,C,F176770110(-) gctaaC/Tacagt 1 -- ng312Minor allele frequency- T:0.10NS 90
    --
    rs64200961,2
    		C,F176769846(+) gcaccG/AggccA 1 -- ng312Minor allele frequency- A:0.03NS 90
    --
    rs178760401,2
    		C,F176770184(-) TCATAC/TCTGTA 1 -- ng312Minor allele frequency- T:0.03NS 94
    rs178760301,2
    		C,F176764432(-) CCGGAC/GCCTTC 1 A/P mis1 ese32Minor allele frequency- G:0.02NS 86
    --
    rs27316761,2
    		C,F176770124(-) tcgagA/Gccatc 1 -- ng312Minor allele frequency- G:0.12NS 90
    --
    rs64200971,2
    		C,F176770106(+) tttcaC/Gtgtgt 1 -- ng312Minor allele frequency- G:0.08NS 90
    About this table

    HapMap Linkage Disequilibrium images for F12 (up to first 250kb)

    Disorders & Mutations
    for F12

    (in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
    About This Section

    		 OMIM: 610619   disorders: 234000  610618  

    UniProtKB/Swiss-Prot: FA12_HUMAN, P00748

  • Defects in F12 are the cause of factor XII deficiency (FA12D) [MIM:234000]; also known as
    Hageman factor deficiency. This trait is an asymptomatic anomaly of in vitro blood coagulation.
    Its diagnosis is based on finding a low plasma activity of the factor in coagulating assays. It is
    usually only accidentally discovered through pre-operative blood tests. F12 deficiency is divided
    into two categories, a cross-reacting material (CRM)-negative group (negative F12 antigen
    detection) and a CRM-positive group (positive F12 antigen detection)
  • Defects in F12 are the cause of hereditary angioedema type 3 (HAE3) [MIM:610618]; also
    known as estrogen-related HAE or hereditary angioneurotic edema with normal C1 inhibitor
    concentration and function. HAE is characterized by episodic local subcutaneous edema, and
    submucosal edema involving the upper respiratory and gastrointestinal tracts. HAE3 occurs
    exclusively in women and is precipitated or worsened by high estrogen levels (e.g., during
    pregnancy or treatment with oral contraceptives). It differs from HAE types 1 and 2 in that both
    concentration and function of C1 inhibitor are normal

    • 10/12 Novoseek disease relationships for F12 gene (see all 12 )

    Disease   Score   Articles   PubMed IDs for Articles with Shared Sentences (# sentences)
    factor xii deficiency 84.33 5 1550105 (1), 12876626 (1), 9856928 (1), 9473199 (1) (see all 5)
    angioedema, hereditary 74.04 2 16638441 (1), 17186468 (1)
    angioedema 53.82 4 19178938 (3)
    thrombophilia 53.09 2 15116249 (1), 10650856 (1)
    miscarriage recurrent 49.17 2 11821096 (1), 11438345 (1)
    venous thrombosis 33.65 2 15116249 (1), 11755949 (1)
    thrombosis 32.20 3 17982641 (1), 10650856 (1), 11755949 (1)
    arterial thrombosis 29.10 1 17388965 (1)
    thromboembolism 19.97 1 9856928 (1)
    cerebrovascular disease 11.86 1 10669178 (1)
    About this table

    Genatlas disease: F12
    Hageman factor deficiency,without bleeding diathesis

    Human Gene Mutation Database: F12
    Genetic Association Database: F12
    Human Genome Epidemiology Navigator: F12 (36 documents)

    Medical News
    for F12

    (Possibly Related Articles in Doctor's Guide)
    About This Section

    		   --

    Publications
    for F12

    (in PubMed. Associations of this gene to articles via 1Novoseek, 2HGNC, 3Entrez Gene, 4UniProtKB/Swiss-Prot, 5UniProtKB/TrEMBL, 6GAD, and/or 7PharmGKB)
    About This Section

    		10/158 PubMed articles for F12 gene (see all 158 ):

    Search for F12

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

     ANDOR
    Aliases
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing F12

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
    About This Section
    Entrez Gene: 2161 HGNC: 3530 AceView: F12 Ensembl:ENSG00000131187 euGenes: HUgn2161
    ECgene: F12 H-InvDB: F12

    Other Databases showing F12

    (According to HUGE)
    About This Section

    		   --

    Specialized Databases showing F12

    (According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    Wikipedia http://en.wikipedia.org/wiki/Factor_XII
    F12basehttp://bioinf.uta.fi/F12base/
    SeattleSNPshttp://pga.gs.washington.edu/data/f12/

    Licensable Technologies
    for F12

    (Available from WIS Yeda, Salk, Tufts)
    About This Section

    		  --

    Services
    for F12

    (Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
    Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
    Enzo Life Sciences, and/or Tocris Bioscience)
    About This Section



    Products for F12:
     TaqMan ® Gene Expression Assays
     TaqMan ® Genotyping Assays
    		  Free SNP selection tool



      Invitrogen iPath Pathways  Invitrogen BLOCK-iT™ RNAi
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      Invitrogen Proteins / Assays / Screening Services  Search Invitrogen catalog for F12-related products

     Millipore Custom Antibody & Bulk Services
     Millipore Preclinical / Clinical Development Services
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     Millipore Target Screening & Profiling Services


     Predesigned and custom siRNAs for F12 Antibodies for F12
     Explore super-pooled esiRNAs Browse proteins at Sigma-Aldrich
     Lentivirus-delivered shRNAs for F12 Browse small molecules at Sigma-Aldrich
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     Search for Antibodies & Assays

     Recombinant Proteins
    (Factor XII heavy chain cleaved Arg372, Factor XII light chain, Factor XII heavy chain, Factor XII)
     Antibodies (Factor XII heavy chain cleaved Arg372, Factor XII light chain, Factor XII heavy chain, Factor XII)
     Search OriGene for F12
     Search Tocris compounds for F12




     Search www.enzolifesicences.com for proteins, assays, substrates, inhibitors & antibodies
     Antibodies for F12

    GeneCards Homepage    -    Last full update: 2 Jul 2009        Incremental update: 13 Oct 2009

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