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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

F11R Gene

protein-coding   GIFtS: 61
GCID: GC01M160965

F11 Receptor

(Previous name: junctional adhesion molecule 1)
(Previous symbol: JAM1)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
F11 Receptor1 2     JAM2
JAM11 2 3 5     JAMA2
Junctional Adhesion Molecule 11 2 3     KAT2
Platelet Adhesion Molecule 12 3     Junctional Adhesion Molecule A2
Platelet F11 Receptor2 3     JAM-13
JCAM2 3     JAM-A3
PAM-12 3     CD321 Antigen3
CD3212     

External Ids:    HGNC: 146851   Entrez Gene: 508482   Ensembl: ENSG000001587697   OMIM: 6057215   UniProtKB: Q9Y6243   

Export aliases for F11R gene to outside databases

Previous GC identifers: GC01M156698 GC01M157743 GC01M158182 GC01M157779 GC01M159231 GC01M132321


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for F11R Gene:
Tight junctions represent one mode of cell-to-cell adhesion in epithelial or endothelial cell sheets, forming
continuous seals around cells and serving as a physical barrier to prevent solutes and water from passing freely
through the paracellular space. The protein encoded by this immunoglobulin superfamily gene member is an
important regulator of tight junction assembly in epithelia. In addition, the encoded protein can act as (1) a
receptor for reovirus, (2) a ligand for the integrin LFA1, involved in leukocyte transmigration, and (3) a
platelet receptor. Multiple 5' alternatively spliced variants, encoding the same protein, have been identified
but their biological validity has not been established. (provided by RefSeq, Jul 2008)

GeneCards Summary for F11R Gene: 
F11R (F11 receptor) is a protein-coding gene. Diseases associated with F11R include occupational dermatitis, and familial combined hyperlipidemia, and among its related super-pathways are Cell-cell junction organization and Sertoli-Sertoli Cell Junction Dynamics. An important paralog of this gene is JAM3.

UniProtKB/Swiss-Prot: JAM1_HUMAN, Q9Y624
Function: Seems to play a role in epithelial tight junction formation. Appears early in primordial forms of cell
junctions and recruits PARD3. The association of the PARD6-PARD3 complex may prevent the interaction of PARD3
with JAM1, thereby preventing tight junction assembly (By similarity). Plays a role in regulating monocyte
transmigration involved in integrity of epithelial barrier. Involved in platelet activation. In case of
orthoreovirus infection, serves as receptor for the virus

Gene Wiki entry for F11R (F11 receptor) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000001.10  NT_004487.19  NC_018912.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the F11R gene promoter:
         NF-1/L   NF-1   Pax-2   Pax-2a   Nkx5-1   GATA-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): F11R promoter sequence
   Search SABiosciences Chromatin IP Primers for F11R

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat F11R


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1q21.2-q21.3   Ensembl cytogenetic band:  1q23.3   HGNC cytogenetic band: 1q21.2-q21.3

F11R Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
F11R gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01M160965:  view genomic region     (about GC identifiers)

Start:
160,965,001 bp from pter      End:
160,991,138 bp from pter
Size:
26,138 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: JAM1_HUMAN, Q9Y624 (See protein sequence)
Recommended Name: Junctional adhesion molecule A precursor  
Size: 299 amino acids; 32583 Da
Subunit: Interacts with the ninth PDZ domain of MPDZ. Interacts with the first PDZ domain of PARD3. The
association between PARD3 and PARD6B probably disrupts this interaction. Interacts with the orthoreovirus sigma-1
capsid protein (By similarity)
Subcellular location: Cell junction, tight junction. Cell membrane; Single-pass type I membrane protein.
Note=Localized at tight junctions of both epithelial and endothelial cells
3 PDB 3D structures from and Proteopedia for F11R:
1NBQ (3D)        3EOY (3D)        3TSZ (3D)    

Explore the universe of human proteins at neXtProt for F11R: NX_Q9Y624

Explore proteomics data for F11R at MOPED 

Post-translational modifications:

  • UniProtKB: N-glycosylated
  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q9Y624

  • F11R Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    F11R Protein Expression
    REFSEQ proteins: NP_058642.1  
    ENSEMBL proteins: 
     ENSP00000357005   ENSP00000440812  
    Reactome Protein details: Q9Y624
    Human Recombinant Protein Products for F11R: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    R&D Systems Recombinant & Natural Proteins for F11R (JAM-A)
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Proteins for F11R
    OriGene Protein Over-expression Lysate for F11R
    OriGene MassSpec for F11R 
    OriGene Custom Protein Services for F11R
    GenScript Custom Purified and Recombinant Proteins Services for F11R
    Novus Biologicals F11R Proteins
    Novus Biologicals F11R Lysates
    Sino Biological Recombinant Protein for F11R
    Sino Biological Cell Lysate for F11R 
    ProSpec Recombinant Protein for F11R
    Browse Proteins at Cloud-Clone Corp. 

    Gene Ontology (GO): 5 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane TAS--
    GO:0005911cell-cell junction TAS10395639
    GO:0005923tight junction IEA--
    GO:0016021integral to membrane IEA--
    GO:0030054cell junction TAS--

    F11R for ontologies           About GeneDecksing



    F11R Antibody Products: 
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    Novus Biologicals F11R Antibodies
    Abcam antibodies for F11R
    Browse Antibodies at Cloud-Clone Corp. 
    ThermoFisher Antibodies for F11R
    Search LSBio for Antibodies for F11R 

    Assay Products for F11R: 
    Browse Kits and Assays available from EMD Millipore
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    R&D Systems Proteome Profiler Antibody Arrays for F11R (JAM-A)
    GenScript Custom Assay Services for F11R
    Browse Enzo Life Sciences for kits & assays
    Browse ELISAs at Cloud-Clone Corp. 
    Browse CLIAs at Cloud-Clone Corp.


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    CD: CD molecules
    IGD: Immunoglobulin superfamily / Immunoglobulin-like domain containing
    VSET: Immunoglobulin superfamily / V-set domain containing

    5 InterPro protein domains:
     IPR003598 Ig_sub2
     IPR003596 Ig_V-set_subgr
     IPR013783 Ig-like_fold
     IPR013106 Ig_V-set
     IPR007110 Ig-like_dom

    Graphical View of Domain Structure for InterPro Entry Q9Y624

    ProtoNet protein and cluster: Q9Y624

    2 Blocks protein domains:
    IPB003596 Immunoglobulin V-type
    IPB003598 Immunoglobulin C-2 type


    UniProtKB/Swiss-Prot: JAM1_HUMAN, Q9Y624
    Similarity: Belongs to the immunoglobulin superfamily
    Similarity: Contains 2 Ig-like V-type (immunoglobulin-like) domains


    F11R for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: JAM1_HUMAN, Q9Y624
    Function: Seems to play a role in epithelial tight junction formation. Appears early in primordial forms of cell
    junctions and recruits PARD3. The association of the PARD6-PARD3 complex may prevent the interaction of PARD3
    with JAM1, thereby preventing tight junction assembly (By similarity). Plays a role in regulating monocyte
    transmigration involved in integrity of epithelial barrier. Involved in platelet activation. In case of
    orthoreovirus infection, serves as receptor for the virus

         Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI17057644
         
    F11R for ontologies           About GeneDecksing


    Phenotypes:
         3 MGI mutant phenotypes (inferred from 4 alleles(MGI details for F11r):
     cardiovascular system  immune system  mortality/aging 

    F11R for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out F11rtm1.1Dej for F11R

       inGenious Targeting Laboratory - Custom generated mouse model solutions for F11R 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for F11R

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for F11R 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for F11R 

    miRNA
    Products:
        
    miRTarBase miRNAs that target F11R:
    hsa-mir-124 (MIRT002678)

    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat F11R
    8/29 QIAGEN miScript miRNA Assays for microRNAs that regulate F11R (see all 29):
    hsa-miR-2052 hsa-miR-4291 hsa-miR-3910 hsa-miR-495 hsa-miR-875-3p hsa-miR-1321 hsa-miR-539 hsa-miR-520d-5p
    SwitchGear 3'UTR luciferase reporter plasmidF11R 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for F11R
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat F11R

    Gene Editing
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    Sirion Biotech Customized adenovirus for overexpression of F11R

    Clone
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    OriGene ORF clones in mouse, rat for F11R
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: F11R (NM_016946)
    Sino Biological Human cDNA Clone for F11R
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for F11R
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat F11R
    Sirion Biotech Customized lentivirus for stable overexpression of F11R 
                         Customized lentivirus expression plasmids for stable overexpression of F11R 

    Cell Line
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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for F11R


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for F11R About   (see all 17)                                                                                              See pathways by source

    SuperPathContained pathways About
    1Cell-cell junction organization
    Cell-cell junction organization0.69
    Cell-Cell communication0.64
    Cell junction organization0.69
    Tight junction interactions0.49
    2Sertoli-Sertoli Cell Junction Dynamics
    Sertoli-Sertoli Cell Junction Dynamics0.38
    Epithelial Tight Junctions0.36
    3Cell adhesion Endothelial cell contacts by junctional mechanisms
    Cell adhesion Endothelial cell contacts by junctional mechanisms0.97
    4Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer
    Signaling by TGF-beta Receptor Complex0.61
    5Signaling by GPCR
    Signal Transduction0.55

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    2 EMD Millipore Pathways for F11R
        Cell adhesion Tight junctions
    Cell adhesion Endothelial cell contacts by junctional mechanisms

    3 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for F11R
        Sertoli-Sertoli Cell Junction Dynamics
    Epithelial Tight Junctions
    Transendothelial Migration of Leukocytes

    2 GeneGo (Thomson Reuters) Pathways for F11R
        Cell adhesion Endothelial cell contacts by junctional mechanisms
    Cell adhesion Tight junctions

    2 BioSystems Pathways for F11R
        Integrins in angiogenesis
    Nectin adhesion pathway


    5/10        Reactome Pathways for F11R (see all 10)
        Hemostasis
    Integrin cell surface interactions
    Tight junction interactions
    Signaling by TGF-beta Receptor Complex
    Signal Transduction


    4         Kegg Pathways  (Kegg details for F11R):
        Cell adhesion molecules (CAMs)
    Tight junction
    Leukocyte transendothelial migration
    Epithelial cell signaling in Helicobacter pylori infection


    F11R for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for F11R

    5/9 Interacting proteins for F11R (Q9Y6242, 3) via UniProtKB, MINT, STRING, and/or I2D (see all 9)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    PARD3Q8TEW02, 3MINT-4085346 MINT-4085691 I2D: score=4 
    CASKO149362, 3MINT-58195 I2D: score=2 
    PRKCZQ055132, 3MINT-4085708 I2D: score=2 
    SGTAO437653I2D: score=3 
    MLLT4P551963I2D: score=2 
    About this table

    Gene Ontology (GO): 5/10 biological process terms (GO ID links to tree view) (see all 10):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006954inflammatory response TAS10395639
    GO:0007155cell adhesion IEA--
    GO:0007179transforming growth factor beta receptor signaling pathway TAS--
    GO:0007596blood coagulation TAS--
    GO:0019048modulation by virus of host morphology or physiology IEA--

    F11R for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    F11R for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for F11R (JAM1)

    3 Novoseek inferred chemical compound relationships for F11R gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    fibrinogen 16.3 1 12008956 (1)
    calcium 0 3 11120739 (1), 10852816 (1), 14528017 (1)
    serine 0 1 11120739 (1)

    Search CenterWatch for drugs/clinical trials and news about F11R / JAM1

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for F11R gene (5 alternative transcripts): 
    NM_016946.4  NM_144501.1  NM_144502.1  NM_144503.1  NM_144504.1  

    Unigene Cluster for F11R:

    F11 receptor
    Hs.517293  [show with all ESTs]
    Unigene Representative Sequence: NM_016946
    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000368026(uc010pjv.2 uc009wtt.3 uc010pjw.2 uc001fxf.4)
    ENST00000537746 ENST00000472573 ENST00000335772 ENST00000602966
    miRNA
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    8/29 QIAGEN miScript miRNA Assays for microRNAs that regulate F11R (see all 29):
    hsa-miR-2052 hsa-miR-4291 hsa-miR-3910 hsa-miR-495 hsa-miR-875-3p hsa-miR-1321 hsa-miR-539 hsa-miR-520d-5p
    SwitchGear 3'UTR luciferase reporter plasmidF11R 3' UTR sequence
    Inhib. RNA
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat F11R
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat F11R

    Additional mRNA sequence: 

    AF154005.1 AF172398.2 AF207907.1 AK026665.1 AK075152.1 AK299487.1 AK304412.1 AL365518.1 
    AY358896.1 BC001533.2 BT020103.1 CR533512.1 

    24/36 DOTS entries (see all 36):

    DT.121464022  DT.101964034  DT.95172353  DT.100827531  DT.91967531  DT.317804  DT.121464000  DT.121464074 
    DT.99946969  DT.121463976  DT.97768628  DT.121463952  DT.121464027  DT.91775010  DT.121464048  DT.121464025 
    DT.91775016  DT.100827543  DT.121463964  DT.100827542  DT.121463973  DT.121464036  DT.95172344  DT.97806888 

    24/597 AceView cDNA sequences (see all 597):

    BM982030 BE792267 AA594510 AI367957 BF727086 CR533512 BU674758 AA359412 
    BX115021 AW149882 AA486163 BM786395 BM681448 BM782522 AI864718 BF916525 
    BF916759 BQ945091 AA741250 AI278896 AI620558 BQ269418 NM_144504 BM970220 

    GeneLoc Exon Structure

    5/18 Alternative Splicing Database (ASD) splice patterns (SP) for F11R (see all 18)    About this scheme

    ExUns: 1a · 1b · 1c · 1d · 1e ^ 2a · 2b · 2c ^ 3 ^ 4a · 4b ^ 5a · 5b · 5c ^ 6 ^ 7 ^ 8 ^ 9 ^ 10a · 10b · 10c · 10d ^ 11a · 11b · 11c · 11d ^
    SP1:                                                                                      -     -     -           -                 -                 -     -   
    SP2:                                -     -     -     -     -     -     -     -     -     -     -     -           -                 -                 -     -   
    SP3:                                                                                      -     -     -           -                 -     -     -     -     -   
    SP4:                                                                                            -     -           -                 -                 -     -   
    SP5:                                                                                                              -                 -                 -     -   

    ExUns: 12a · 12b · 12c ^ 13 ^ 14 ^ 15 ^ 16 ^ 17
    SP1:                                                
    SP2:                                                
    SP3:                                                
    SP4:                                                
    SP5:                                                


    ECgene alternative splicing isoforms for F11R

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    F11R expression in normal human tissues (normalized intensities)      F11R embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GGGAAGCAGA
    F11R Expression
    About this image


    F11R expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/39 selected tissues (see all 39) fully expand
     
     Epithelium
             vagina ; squamous epithelial cells   
     
     Nose (Sensory Organs)    fully expand to see all 6 entries
             nasopharynx ; respiratory epithelial cells   
             sensory organ/nose/naso-lacrimal duct   
     
     Lung (Respiratory System)    fully expand to see all 5 entries
             Trachea
             lung ; pneumocytes   
     
     Testis (Reproductive System)    fully expand to see all 4 entries
             Leydig Cells Testis Interstitium
             seminal vesicle ; glandular cells   
     
     Brain (Nervous System)    fully expand to see all 4 entries
             Mature Choroid Plexus Cells Choroid Plexus
             Cerebral Cortex

    See F11R Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for F11R

    SOURCE GeneReport for Unigene cluster: Hs.517293
        SABiosciences Expression via Pathway-Focused PCR Arrays including F11R: 
              Tight Junctions in human mouse rat
              Cell Junction PathwayFinder in human mouse rat
              Epithelial to Mesenchymal Transition (EMT) in human mouse rat
              Inflammatory Response & Autoimmunity 384HT in human mouse rat

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for F11R gene from 3/9 species (see all 9)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia F11r1 , 5 F11 receptor1, 5 77.52(n)1
    69.13(a)1
      1 (79.43 cM)5
    164561  NM_172647.21  NP_766235.11 
     1714375355 
    African clawed frog
    (Xenopus laevis)
    Amphibia LOC3986272 hypothetical protein LOC398627 77.17(n)    BC054305.1 
    zebrafish
    (Danio rerio)
    Actinopterygii f11r1 F11 receptor 53.59(n)
    45(a)
      323696  NM_001004667.2  NP_001004667.1 


    ENSEMBL Gene Tree for F11R (if available)
    TreeFam Gene Tree for F11R (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for F11R gene
    JAM32  JAM22  
    2 SIMAP similar genes for F11R using alignment to 5 protein entries:     JAM1_HUMAN (see all proteins):
    JAM2    JAM3

    F11R for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/578 SNPs in F11R are shown (see all 578)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs24810761,2
    C--160964697(+) tttaaG/Aaccag 1 -- ds50018Minor allele frequency- A:0.00NA WA CSA 15
    rs1434261771,2
    --160964722(+) TGAAAA/CCCTGT 1 -- ds50010--------
    rs727128541,2
    C,F--160964744(+) CTATTA/TAAAAA 1 -- ds50012Minor allele frequency- T:0.27NA EA 240
    rs1460672291,2
    C--160964755(+) AAAATC/TATCCG 1 -- ds50010--------
    rs1114629391,2
    C--160964883(+) GTGAT-/AAGAGT 1 -- ds50011Minor allele frequency- A:0.50CSA 2
    rs1130095971,2
    C--160964883(+) GGTGAC/TAGAGT 1 -- ds50011Minor allele frequency- T:0.50NA 2
    rs2013520911,2
    C--160964901(+) AAAAA-/AAGAAAG 1 -- ds50010--------
    rs618036641,2
    C,F--160964983(+) AAGGGG/TTAATA 1 -- ds50015Minor allele frequency- T:0.20NA WA EA 362
    rs1507800071,2
    --160965031(+) AAATTA/GTTGTT 1 -- ut310--------
    rs1915241371,2
    --160965266(+) TGGCCA/GGGTGC 1 -- ut310--------

    HapMap Linkage Disequilibrium report for F11R (160965001 - 160991138 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for F11R:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2667660CNV Deletion23128226

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 605721    OMIM disorders: --

    20 diseases for F11R:    About MalaCards
    occupational dermatitis    familial combined hyperlipidemia    clear cell renal cell carcinoma    thrombosis
    renal cell carcinoma    endotheliitis    atherosclerosis    endometrial carcinoma
    inflammatory bowel disease    dermatitis    multiple sclerosis    obesity
    hepatitis b    hypertension    cerebritis    myeloid leukemia
    colorectal cancer    hepatitis    breast cancer    leukemia


    F11R for disorders           About GeneDecksing

    5 Novoseek inferred disease relationships for F11R gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    thrombosis 27.9 1 17481380 (1)
    atherosclerosis 11.1 1 17964041 (1)
    necrosis 7.38 1 15886398 (1)
    inflammation 0 2 17481380 (1), 17615384 (1)
    tumors 0 1 15886398 (1)

    Genetic Association Database (GAD): F11R
    Human Genome Epidemiology (HuGE) Navigator: F11R (11 documents)

    Export disorders for F11R gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for F11R gene, integrated from 9 sources (see all 136):
    (articles sorted by number of sources associating them with F11R)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Combined treatment of TNF-alpha and IFN-gamma causes redistribution of junctional adhesion molecule in human endothelial cells. (PubMed id 10395639)1, 2, 3 Ozaki H.... Kita T. (1999)
    2. Mechanisms of platelet activation by a stimulatory antibody: cross- linking of a novel platelet receptor for monoclonal antibody F11 with the Fc gamma RII receptor. (PubMed id 7646439)1, 2, 3 Naik U.P.... Kornecki E. (1995)
    3. Characterization and chromosomal localization of JAM-1, a platelet receptor for a stimulatory monoclonal antibody. (PubMed id 11171323)1, 2, 9 Naik U.P.... Spychala J. (2001)
    4. Association of F11 receptor gene polymorphisms with central obesity and blood pressure. (PubMed id 18067551)1, 4, 9 Ong K.L....Cheung B.M. (2008)
    5. Cloning of the human platelet F11 receptor: a cell adhesion molecule member of the immunoglobulin superfamily involved in platelet aggregation. (PubMed id 10753840)1, 2, 9 Sobocka M.B.... Kornecki E. (2000)
    6. Variation at the NFATC2 locus increases the risk of t hiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipr il and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1, 4 Bailey S.D....Anand S. (2010)
    7. Signal peptide prediction based on analysis of experimentally verified cleavage sites. (PubMed id 15340161)1, 2 Zhang Z. and Henzel W.J. (2004)
    8. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    9. Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides. (PubMed id 12665801)1, 2 Gevaert K.... Vandekerckhove J. (2003)
    10. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PubMed id 12975309)1, 2 Clark H.F.... Gray A.M. (2003)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 50848 HGNC: 14685 AceView: F11R Ensembl:ENSG00000158769 euGenes: HUgn50848
    ECgene: F11R Kegg: 50848 H-InvDB: F11R

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for F11R Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for F11R gene:
    Search GeneIP for patents involving F11R

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    About This Section

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