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F11R Gene

protein-coding   GIFtS: 61
GCID: GC01M160965

F11 Receptor

(Previous name: junctional adhesion molecule 1)
(Previous symbol: JAM1)
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
F11 Receptor1 2     JAM2
JAM11 2 3 5     JAMA2
Junctional Adhesion Molecule 11 2 3     KAT2
Platelet Adhesion Molecule 12 3     Junctional Adhesion Molecule A2
Platelet F11 Receptor2 3     JAM-13
JCAM2 3     JAM-A3
PAM-12 3     CD321 Antigen3
CD3212     

External Ids:    HGNC: 146851   Entrez Gene: 508482   Ensembl: ENSG000001587697   OMIM: 6057215   UniProtKB: Q9Y6243   

Export aliases for F11R gene to outside databases

Previous GC identifers: GC01M156698 GC01M157743 GC01M158182 GC01M157779 GC01M159231 GC01M132321


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for F11R Gene:
Tight junctions represent one mode of cell-to-cell adhesion in epithelial or endothelial cell sheets, forming
continuous seals around cells and serving as a physical barrier to prevent solutes and water from passing freely
through the paracellular space. The protein encoded by this immunoglobulin superfamily gene member is an
important regulator of tight junction assembly in epithelia. In addition, the encoded protein can act as (1) a
receptor for reovirus, (2) a ligand for the integrin LFA1, involved in leukocyte transmigration, and (3) a
platelet receptor. Multiple 5' alternatively spliced variants, encoding the same protein, have been identified
but their biological validity has not been established. (provided by RefSeq, Jul 2008)

GeneCards Summary for F11R Gene:
F11R (F11 receptor) is a protein-coding gene. An important paralog of this gene is JAM3.

UniProtKB/Swiss-Prot: JAM1_HUMAN, Q9Y624
Function: Seems to play a role in epithelial tight junction formation. Appears early in primordial forms of cell
junctions and recruits PARD3. The association of the PARD6-PARD3 complex may prevent the interaction of PARD3
with JAM1, thereby preventing tight junction assembly (By similarity). Plays a role in regulating monocyte
transmigration involved in integrity of epithelial barrier. Involved in platelet activation. In case of
orthoreovirus infection, serves as receptor for the virus

Gene Wiki entry for F11R (F11 receptor) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000001.10  NC_018912.2  NT_004487.20  
Regulatory elements:
   Regulatory transcription factor binding sites in the F11R gene promoter:
         NF-1/L   NF-1   Pax-2   Pax-2a   Nkx5-1   GATA-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): F11R promoter sequence
   Search Chromatin IP Primers for F11R

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat F11R


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1q21.2-q21.3   Ensembl cytogenetic band:  1q23.3   HGNC cytogenetic band: 1q21.2-q21.3

F11R Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
F11R gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01M160965:  view genomic region     (about GC identifiers)

Start:
160,965,001 bp from pter      End:
160,991,138 bp from pter
Size:
26,138 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: JAM1_HUMAN, Q9Y624 (See protein sequence)
Recommended Name: Junctional adhesion molecule A precursor  
Size: 299 amino acids; 32583 Da
Subunit: Interacts with the ninth PDZ domain of MPDZ. Interacts with the first PDZ domain of PARD3. The
association between PARD3 and PARD6B probably disrupts this interaction. Interacts with the orthoreovirus sigma-1
capsid protein (By similarity)
3 PDB 3D structures from and Proteopedia for F11R:
1NBQ (3D)        3EOY (3D)        3TSZ (3D)    

Explore the universe of human proteins at neXtProt for F11R: NX_Q9Y624

Explore proteomics data for F11R at MOPED

Post-translational modifications: 

  • N-glycosylated1
  • Ubiquitination2 at Lys97, Lys277
  • Glycosylation2 at Thr175, Asn185
  • Modification sites at PhosphoSitePlus

  • See F11R Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_058642.1  
    ENSEMBL proteins: 
     ENSP00000357005   ENSP00000440812  
    Reactome Protein details: Q9Y624

    F11R Human Recombinant Protein Products:

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    Novus Biologicals F11R Proteins
    Novus Biologicals F11R Lysates
    Sino Biological Recombinant Protein for F11R
    Sino Biological Cell Lysate for F11R
    ProSpec Recombinant Protein for F11R
    Browse Proteins at Cloud-Clone Corp.

     
    Search eBioscience for Proteins for F11R 

     
    antibodies-online proteins for F11R (13 products) 

     
    antibodies-online peptides for F11R

    F11R Antibody Products:

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    antibodies-online antibodies for F11R (68 products) 

    F11R Assay Products:

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    Browse ELISAs at Cloud-Clone Corp.
    Browse CLIAs at Cloud-Clone Corp.
    Search eBioscience for ELISAs for F11R 
    antibodies-online kits for F11R (13 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    CD: CD molecules
    IGD: Immunoglobulin superfamily / Immunoglobulin-like domain containing
    VSET: Immunoglobulin superfamily / V-set domain containing

    5 InterPro protein domains:
     IPR003598 Ig_sub2
     IPR003596 Ig_V-set_subgr
     IPR013783 Ig-like_fold
     IPR013106 Ig_V-set
     IPR007110 Ig-like_dom

    Graphical View of Domain Structure for InterPro Entry Q9Y624

    ProtoNet protein and cluster: Q9Y624

    2 Blocks protein domains:
    IPB003596 Immunoglobulin V-type
    IPB003598 Immunoglobulin C-2 type


    UniProtKB/Swiss-Prot: JAM1_HUMAN, Q9Y624
    Similarity: Belongs to the immunoglobulin superfamily
    Similarity: Contains 2 Ig-like V-type (immunoglobulin-like) domains


    Find genes that share domains with F11R           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: JAM1_HUMAN, Q9Y624
    Function: Seems to play a role in epithelial tight junction formation. Appears early in primordial forms of cell
    junctions and recruits PARD3. The association of the PARD6-PARD3 complex may prevent the interaction of PARD3
    with JAM1, thereby preventing tight junction assembly (By similarity). Plays a role in regulating monocyte
    transmigration involved in integrity of epithelial barrier. Involved in platelet activation. In case of
    orthoreovirus infection, serves as receptor for the virus

         Gene Ontology (GO): 1 molecular function term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI17057644
         
    Find genes that share ontologies with F11R           About GenesLikeMe


    Phenotypes:
         3 MGI mutant phenotypes (inferred from 4 alleles(MGI details for F11r):
     cardiovascular system  immune system  mortality/aging 

    Find genes that share phenotypes with F11R           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out F11rtm1.1Dej for F11R

       genOway: Develop your customized and physiologically relevant rodent model for F11R

    miRNA
    Products:
        
    miRTarBase miRNAs that target F11R:
    hsa-mir-1 (MIRT024072), hsa-mir-335-5p (MIRT019092), hsa-mir-145-5p (MIRT021501), hsa-mir-124-3p (MIRT002678)

    Block miRNA regulation of human, mouse, rat F11R using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate F11R (see all 29):
    hsa-miR-2052 hsa-miR-4291 hsa-miR-3910 hsa-miR-495 hsa-miR-875-3p hsa-miR-1321 hsa-miR-539 hsa-miR-520d-5p
    SwitchGear 3'UTR luciferase reporter plasmidF11R 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat F11R

    Gene Editing
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    GenScript: all cDNA clones in your preferred vector: F11R (NM_016946)
    Sino Biological Human cDNA Clone for F11R
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat F11R

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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for F11R


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    JAM1_HUMAN, Q9Y624: Cell junction, tight junction. Cell membrane; Single-pass type I membrane protein.
    Note=Localized at tight junctions of both epithelial and endothelial cells
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane5
    extracellular2
    cytoskeleton1
    endoplasmic reticulum1
    endosome1
    peroxisome1

    Gene Ontology (GO): Selected cellular component terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane TAS--
    GO:0005911cell-cell junction TAS10395639
    GO:0005923tight junction IEA--
    GO:0015630microtubule cytoskeleton IDA--
    GO:0016021integral component of membrane IEA--

    Find genes that share ontologies with F11R           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for F11R About   (see all 18)  
    See pathways by source

    SuperPathSelected contained pathways About (see all per SuperPath)
    1Loss of Function of SMAD2/3 in Cancer
    Loss of Function of SMAD2/3 in Cancer0.60
    TGFBR1 KD Mutants in Cancer0.60
    Loss of Function of SMAD4 in Cancer0.60
    SMAD2/3 MH2 Domain Mutants in Cancer0.60
    TGFBR2 MSI Frameshift Mutants in Cancer0.60
    SMAD2/3 Phosphorylation Motif Mutants in Cancer0.60
    Signaling by TGF-beta Receptor Complex in Cancer0.60
    SMAD4 MH2 Domain Mutants in Cancer0.60
    2Cell junction organization
    Cell junction organization0.70
    Cell-Cell communication0.64
    Cell-cell junction organization0.70
    Tight junction interactions0.51
    3Sertoli-Sertoli Cell Junction Dynamics
    Sertoli-Sertoli Cell Junction Dynamics0.38
    Epithelial Tight Junctions0.36
    4Signaling by GPCR
    Signal Transduction0.58
    5Hemostasis
    Hemostasis0.43


    Find genes that share SuperPaths with F11R           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    3 Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for F11R
        Sertoli-Sertoli Cell Junction Dynamics
    Epithelial Tight Junctions
    Transendothelial Migration of Leukocytes

    2 GeneGo (Thomson Reuters) Pathways for F11R
        Cell adhesion Endothelial cell contacts by junctional mechanisms
    Cell adhesion Tight junctions

    2 BioSystems Pathways for F11R
        Integrins in angiogenesis
    Nectin adhesion pathway


    4 Reactome Pathways for F11R
        Integrin cell surface interactions
    Tight junction interactions
    TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)
    Cell surface interactions at the vascular wall


    4 Kegg Pathways  (Kegg details for F11R):
        Cell adhesion molecules (CAMs)
    Tight junction
    Leukocyte transendothelial migration
    Epithelial cell signaling in Helicobacter pylori infection

        Pathway & Disease-focused RT2 Profiler PCR Arrays including F11R: 
              Tight Junctions in human mouse rat
              Cell Junction PathwayFinder in human mouse rat
              Epithelial to Mesenchymal Transition (EMT) in human mouse rat
              Inflammatory Response & Autoimmunity 384HT in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for F11R

    Selected Interacting proteins for F11R (Q9Y6241, 2, 3) via UniProtKB, MINT, STRING, and/or I2D (see all 9)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    PARD3Q8TEW01, 2, 3EBI-742600,EBI-81968 MINT-4085346 MINT-4085691 I2D: score=4 
    CASKO149362, 3MINT-58195 I2D: score=2 
    PRKCZQ055132, 3MINT-4085708 I2D: score=2 
    SGTAO437653I2D: score=3 
    MLLT4P551963I2D: score=2 
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 12):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006954inflammatory response TAS10395639
    GO:0007155cell adhesion IEA--
    GO:0007179transforming growth factor beta receptor signaling pathway TAS--
    GO:0007596blood coagulation TAS--
    GO:0016032viral process IEA--

    Find genes that share ontologies with F11R           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for F11R (JAM1)

    3 Novoseek inferred chemical compound relationships for F11R gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    fibrinogen 16.3 1 12008956 (1)
    calcium 0 3 11120739 (1), 10852816 (1), 14528017 (1)
    serine 0 1 11120739 (1)



    Find genes that share compounds with F11R           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for F11R gene (5 alternative transcripts): 
    NM_016946.4  NM_144501.1  NM_144502.1  NM_144503.1  NM_144504.1  

    Unigene Cluster for F11R:

    F11 receptor
    Hs.517293  [show with all ESTs]
    Unigene Representative Sequence: NM_016946
    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000368026(uc010pjv.2 uc009wtt.3 uc010pjw.2 uc001fxf.4)
    ENST00000537746 ENST00000472573 ENST00000335772 ENST00000602966
    miRNA
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    hsa-miR-2052 hsa-miR-4291 hsa-miR-3910 hsa-miR-495 hsa-miR-875-3p hsa-miR-1321 hsa-miR-539 hsa-miR-520d-5p
    SwitchGear 3'UTR luciferase reporter plasmidF11R 3' UTR sequence
    Inhib. RNA
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    Primer
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      QuantiTect SYBR Green Assays in human, mouse, rat F11R
      QuantiFast Probe-based Assays in human, mouse, rat F11R

    Additional mRNA sequence: 

    AF154005.1 AF172398.2 AF207907.1 AK026665.1 AK075152.1 AK299487.1 AK304412.1 AL365518.1 
    AY358896.1 BC001533.2 BT020103.1 CR533512.1 

    Selected DOTS entries (see all 36):

    DT.121464022  DT.101964034  DT.95172353  DT.100827531  DT.91967531  DT.317804  DT.121464000  DT.121464074 
    DT.99946969  DT.121463976  DT.97768628  DT.121463952  DT.121464027  DT.91775010  DT.121464048  DT.121464025 
    DT.91775016  DT.100827543  DT.121463964  DT.100827542  DT.121463973  DT.121464036  DT.95172344  DT.97806888 

    Selected AceView cDNA sequences (see all 597):

    AW292186 AA576950 AI460272 AA486163 BE792267 BG742621 AA780046 BE561354 
    BC038219 AI739011 CR533512 AI278896 BE305089 BX327155 BQ685315 BF916525 
    NM_144502 BU674758 AI282728 NM_016946 CR617300 AA404390 BQ269418 AA486100 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for F11R (see all 18)    About this scheme

    ExUns: 1a · 1b · 1c · 1d · 1e ^ 2a · 2b · 2c ^ 3 ^ 4a · 4b ^ 5a · 5b · 5c ^ 6 ^ 7 ^ 8 ^ 9 ^ 10a · 10b · 10c · 10d ^ 11a · 11b · 11c · 11d ^
    SP1:                                                                                      -     -     -           -                 -                 -     -   
    SP2:                                -     -     -     -     -     -     -     -     -     -     -     -           -                 -                 -     -   
    SP3:                                                                                      -     -     -           -                 -     -     -     -     -   
    SP4:                                                                                            -     -           -                 -                 -     -   
    SP5:                                                                                                              -                 -                 -     -   

    ExUns: 12a · 12b · 12c ^ 13 ^ 14 ^ 15 ^ 16 ^ 17
    SP1:                                                
    SP2:                                                
    SP3:                                                
    SP4:                                                
    SP5:                                                


    ECgene alternative splicing isoforms for F11R

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

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    F11R expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GGGAAGCAGA
    F11R Expression
    About this image


    F11R expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 22) fully expand
     
     Brain (Nervous System)    fully expand to see all 4 entries
             Mature Choroid Plexus Cells Choroid Plexus
             Cerebral Cortex
     
     Inner Cell Mass (Early Embryonic Tissues)    fully expand to see all 4 entries
             Human embryonic stem cells (family)
     
     Gut Tube (Gastrointestinal Tract)    fully expand to see all 3 entries
             Hindgut
     
     Ovary (Reproductive System)    fully expand to see all 2 entries
             Ovarian Mesenchymal Stroma Cells Ovary Interstitium
             Oviduct
     
     Blood (Hematopoietic System)    fully expand to see all 2 entries
             Hematopoietic Stem Cells Hematopoietic Bone Marrow
    F11R Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    F11R Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.517293
        Pathway & Disease-focused RT2 Profiler PCR Arrays including F11R: 
              Tight Junctions in human mouse rat
              Cell Junction PathwayFinder in human mouse rat
              Epithelial to Mesenchymal Transition (EMT) in human mouse rat
              Inflammatory Response & Autoimmunity 384HT in human mouse rat

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for F11R gene from Selected species (see all 9)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia F11r1 , 5 F11 receptor1, 5 77.52(n)1
    69.13(a)1
      1 (79.43 cM)5
    164561  NM_172647.21  NP_766235.11 
     1714375355 
    African clawed frog
    (Xenopus laevis)
    Amphibia LOC3986272 hypothetical protein LOC398627 77.17(n)    BC054305.1 
    zebrafish
    (Danio rerio)
    Actinopterygii f11r1 F11 receptor 54.36(n)
    45.77(a)
      323696  NM_001004667.3  NP_001004667.1 


    ENSEMBL Gene Tree for F11R (if available)
    TreeFam Gene Tree for F11R (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for F11R gene
    JAM32  JAM22  
    2 SIMAP similar genes for F11R using alignment to 4 protein entries:     JAM1_HUMAN (see all proteins):
    JAM2    JAM3

    Find genes that share paralogs with F11R           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for F11R (see all 578)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs24810761,2
    C--160964697(+) tttaaG/Aaccag 1 -- ds50018Minor allele frequency- A:0.00NA WA CSA 15
    rs1434261771,2
    --160964722(+) TGAAAA/CCCTGT 1 -- ds50010--------
    rs727128541,2
    C,F--160964744(+) CTATTA/TAAAAA 1 -- ds50012Minor allele frequency- T:0.27NA EA 240
    rs1460672291,2
    C--160964755(+) AAAATC/TATCCG 1 -- ds50010--------
    rs1114629391,2
    C--160964883(+) GTGAT-/AAGAGT 1 -- ds50011Minor allele frequency- A:0.50CSA 2
    rs1130095971,2
    C--160964883(+) GGTGAC/TAGAGT 1 -- ds50011Minor allele frequency- T:0.50NA 2
    rs2013520911,2
    C--160964901(+) AAAAA-/AAGAAAG 1 -- ds50010--------
    rs618036641,2
    C,F--160964983(+) AAGGGG/TTAATA 1 -- ds50015Minor allele frequency- T:0.20NA WA EA 362
    rs1507800071,2
    --160965031(+) AAATTA/GTTGTT 1 -- ut310--------
    rs1915241371,2
    --160965266(+) TGGCCA/GGGTGC 1 -- ut310--------

    HapMap Linkage Disequilibrium report for F11R (160965001 - 160991138 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for F11R:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2667660CNV Deletion23128226

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing F11R
    DNA2.0 Custom Variant and Variant Library Synthesis for F11R

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 605721    OMIM disorders: --


    Find genes that share disorders with F11R           About GenesLikeMe

    5 Novoseek inferred disease relationships for F11R gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    thrombosis 27.9 1 17481380 (1)
    atherosclerosis 11.1 1 17964041 (1)
    necrosis 7.38 1 15886398 (1)
    inflammation 0 2 17481380 (1), 17615384 (1)
    tumors 0 1 15886398 (1)

    Genetic Association Database (GAD): F11R
    Human Genome Epidemiology (HuGE) Navigator: F11R (11 documents)

    Export disorders for F11R gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for F11R gene, integrated from 10 sources (see all 138):
    (articles sorted by number of sources associating them with F11R)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Combined treatment of TNF-alpha and IFN-gamma causes redistribution of junctional adhesion molecule in human endothelial cells. (PubMed id 10395639)1, 2, 3 Ozaki H.... Kita T. (J. Immunol. 1999)
    2. Mechanisms of platelet activation by a stimulatory antibody: cross- linking of a novel platelet receptor for monoclonal antibody F11 with the Fc gamma RII receptor. (PubMed id 7646439)1, 2, 3 Naik U.P.... Kornecki E. (Biochem. J. 1995)
    3. Characterization and chromosomal localization of JAM-1, a platelet receptor for a stimulatory monoclonal antibody. (PubMed id 11171323)1, 2, 9 Naik U.P.... Spychala J. (J. Cell Sci. 2001)
    4. Association of F11 receptor gene polymorphisms with central obesity and blood pressure. (PubMed id 18067551)1, 4, 9 Ong K.L....Cheung B.M. (J. Intern. Med. 2008)
    5. Cloning of the human platelet F11 receptor: a cell adhesion molecule member of the immunoglobulin superfamily involved in platelet aggregation. (PubMed id 10753840)1, 2, 9 Sobocka M.B.... Kornecki E. (Blood 2000)
    6. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1, 4 Bailey S.D....Anand S. (Diabetes Care 2010)
    7. Signal peptide prediction based on analysis of experimentally verified cleavage sites. (PubMed id 15340161)1, 2 Zhang Z. and Henzel W.J. (Protein Sci. 2004)
    8. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    9. Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides. (PubMed id 12665801)1, 2 Gevaert K.... Vandekerckhove J. (Nat. Biotechnol. 2003)
    10. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PubMed id 12975309)1, 2 Clark H.F.... Gray A.M. (Genome Res. 2003)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 50848 HGNC: 14685 AceView: F11R Ensembl:ENSG00000158769 euGenes: HUgn50848
    ECgene: F11R Kegg: 50848 H-InvDB: F11R

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for F11R Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for F11R gene:
    Search GeneIP for patents involving F11R

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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