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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

F11R Gene

protein-coding   GIFtS: 63
GCID: GC01M160965

F11 receptor

(Previous name: junctional adhesion molecule 1 )
(Previous symbol: JAM1)
 Explore 22 diseases affiliated with
F11R via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for F11R    

Aliases
for F11R gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
F11 Receptor1 2     JAM-A1 3
JAM11 2 3 5     Platelet Adhesion Molecule 12 3
Junctional Adhesion Molecule 11 2 3     Platelet F11 Receptor2 3
JCAM1 2 3     JAM2
PAM-11 2 3     KAT2
CD3211 2     Junctional Adhesion Molecule A2
JAMA1 2     CD321 Antigen3
JAM-11 3     

External Ids:    HGNC: 146851   Entrez Gene: 508482   Ensembl: ENSG000001587697   OMIM: 6057215   UniProtKB: Q9Y6243   

Export aliases for F11R gene to outside databases

Previous GC identifers: GC01M156698 GC01M157743 GC01M158182 GC01M157779 GC01M159231 GC01M132321


Summaries
for F11R gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for F11R:
Tight junctions represent one mode of cell-to-cell adhesion in epithelial or endothelial cell sheets, forming
continuous seals around cells and serving as a physical barrier to prevent solutes and water from passing freely
through the paracellular space. The protein encoded by this immunoglobulin superfamily gene member is an important
regulator of tight junction assembly in epithelia. In addition, the encoded protein can act as (1) a receptor for
reovirus, (2) a ligand for the integrin LFA1, involved in leukocyte transmigration, and (3) a platelet receptor.
Multiple 5' alternatively spliced variants, encoding the same protein, have been identified but their biological
validity has not been established. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: JAM1_HUMAN, Q9Y624
Function: Seems to play a role in epithelial tight junction formation. Appears early in primordial forms of cell
junctions and recruits PARD3. The association of the PARD6-PARD3 complex may prevent the interaction of PARD3 with
JAM1, thereby preventing tight junction assembly (By similarity). Plays a role in regulating monocyte transmigration
involved in integrity of epithelial barrier. Involved in platelet activation. In case of orthoreovirus infection,
serves as receptor for the virus

Gene Wiki entry for F11R (F11 receptor)


Genomic Views
for F11R gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000001.10  NC_018912.1  NT_004487.19  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the F11R gene promoter:
         NF-1/L   NF-1   Pax-2   Pax-2a   Nkx5-1   GATA-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): F11R promoter sequence
   Search SABiosciences Chromatin IP Primers for F11R

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat F11R


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1q21.2-q21.3   Ensembl cytogenetic band:  1q23.3   HGNC cytogenetic band: 1q21.2-q21.3

F11R Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
F11R gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01M160965:  view genomic region     (about GC identifiers)

Start:
 160,965,001 bp from pter      End:
 161,008,784 bp from pter
Size:
 43,784 bases      Orientation:
 minus strand

Proteins
for F11R gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: JAM1_HUMAN, Q9Y624 (See protein sequence)
Recommended Name: Junctional adhesion molecule A precursor  
Size: 299 amino acids; 32583 Da
Subunit: Interacts with the ninth PDZ domain of MPDZ. Interacts with the first PDZ domain of PARD3. The association
between PARD3 and PARD6B probably disrupts this interaction. Interacts with the orthoreovirus sigma-1 capsid protein
(By similarity)
Subcellular location: Cell junction, tight junction. Cell membrane; Single-pass type I membrane protein. Note=Localized
at tight junctions of both epithelial and endothelial cells
3 PDB 3D structures from and Proteopedia for F11R:
1NBQ (3D)        3EOY (3D)        3TSZ (3D)    

Explore the universe of human proteins at neXtProt for F11R: NX_Q9Y624

Post-translational modifications:

  • N-glycosylated1
  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q9Y624

    • F11R Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_058642.1  
    ENSEMBL proteins: 
     ENSP00000357005   ENSP00000337141   ENSP00000289779   ENSP00000394809   ENSP00000440812  
    Reactome Protein details: Q9Y624
    Human Recombinant Protein Products: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    R&D Systems Recombinant & Natural Proteins for F11R (JAM-A)
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Proteins (see all 3): F11R
    OriGene Protein Over-expression Lysate (see all 4): F11R
    OriGene Custom Protein Services for F11R 
    GenScript Custom Purified and Recombinant Proteins Services for F11R
    Novus Biologicals F11R Proteins
    Novus Biologicals F11R Lysates
    Sino Biological Recombinant Protein for F11R
    ProSpec Recombinant Protein for F11R
    Uscn Proteins for F11R

    Gene Ontology (GO): 5 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane TAS--
    GO:0005911cell-cell junction TAS10395639
    GO:0005923tight junction IEA--
    GO:0016021integral to membrane IEA--
    GO:0030054cell junction TAS--


    F11R for ontologies           About GeneDecksing



    F11R Antibody Products: 
    EMD Millipore Mono- and Polyclonal Antibodies for the study of F11R
    R&D Systems Antibodies for F11R (JAM-A)
    OriGene Antibodies (see all 3): F11R
    OriGene Custom Antibody Services for F11R 
    GenScript Custom Superior Antibodies Services for F11R
    Novus Biologicals F11R Antibodies
    Abcam antibodies for F11R 
    Uscn Antibodies for F11R
    ThermoFisher Antibodies for F11R

    Assay Products for F11R: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Immunoassay Development
    Browse OriGene Fluorogenic Cell Assay Kits
    R&D Systems Multiplex/Array Assay Kits & Reagents for F11R (JAM-A)
    GenScript Custom Assay Services for F11R
    Browse Enzo Life Sciences for kits & assays
    Uscn ELISAs and CLIAs for F11R

    Protein Domains /
    Families
    for F11R gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    F11R for domains           About GeneDecksing

    5 InterPro domains/families:
     IPR003598 Ig_sub2
     IPR003596 Ig_V-set_subgr
     IPR013783 Ig-like_fold
     IPR013106 Ig_V-set
     IPR007110 Ig-like_dom

    Graphical View of Domain Structure for InterPro Entry Q9Y624

    ProtoNet protein and cluster: Q9Y624

    2 Blocks protein families:
    IPB003596 Immunoglobulin V-type
    IPB003598 Immunoglobulin C-2 type


    UniProtKB/Swiss-Prot: JAM1_HUMAN, Q9Y624
    Similarity: Belongs to the immunoglobulin superfamily
    Similarity: Contains 2 Ig-like V-type (immunoglobulin-like) domains


    Function
    for F11R gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: JAM1_HUMAN, Q9Y624
    Function: Seems to play a role in epithelial tight junction formation. Appears early in primordial forms of cell
    junctions and recruits PARD3. The association of the PARD6-PARD3 complex may prevent the interaction of PARD3 with
    JAM1, thereby preventing tight junction assembly (By similarity). Plays a role in regulating monocyte transmigration
    involved in integrity of epithelial barrier. Involved in platelet activation. In case of orthoreovirus infection,
    serves as receptor for the virus

    miRNA
    Products:            		miRTarBase miRNAs that target F11R:
    hsa-mir-124 (MIRT002678)

    OriGene 3'-UTR Clone: F11R
    Browse MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat F11R
    8/29 QIAGEN miScript miRNA Assays for microRNAs that regulate F11R (see all 29):
    hsa-miR-2052 hsa-miR-4291 hsa-miR-3910 hsa-miR-495 hsa-miR-875-3p hsa-miR-1321 hsa-miR-539 hsa-miR-520d-5p
    SwitchGear 3'UTR luciferase reporter plasmid: F11R 3' UTR sequence
    Inhib. RNA
    Products:            		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for F11R (see all 7)
    OriGene shRNA RFP: F11R
    OriGene siRNA: F11R
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat F11R

    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for F11R

    Clone
    Products:             		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for F11R (see all 5)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for F11R (see all 4)
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector: F11R (NM_016946)
    Sino Biological Human cDNA Clone for F11R
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for F11R
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat F11R 

    Cell Line
    Products:             		GenScript Custom overexpressing Cell Line Services for F11R
    Search LifeMap BioReagents cell lines for F11R

    In Situ Assay
    Products:       
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for F11R

    Animal Models:
         Mouse knock-out F11rtm1.1Dej for F11R
         3 MGI mutant phenotypes (inferred from 4 alleles) (MGI details for F11r):
     cardiovascular system  immune system  mortality/aging 

    F11R for phenotypes           About GeneDecksing


    Pathways & Interactions
    for F11R gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways - 5/17 super-pathways (see all 17) About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Cell-cell junction organization
    		Cell-cell junction organization1.00
    		Tight junction interactions0.49
    		Cell junction organization0.69
    		Cell-Cell communication0.45
    2TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)
    		TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)1.00
    		Disassembly of tight junctions0.94
    3Cell adhesion Tight junctions
    		Cell adhesion Tight junctions1.00
    		Cell adhesion_Tight junctions0.99
    4Cell adhesion Endothelial cell contacts by junctional mechanisms
    		Cell adhesion Endothelial cell contacts by junctional mechanisms1.00
    		Cell adhesion_Endothelial cell contacts by junctional mechanisms0.97
    5Sertoli-Sertoli Cell Junction Dynamics
    		Sertoli-Sertoli Cell Junction Dynamics1.00
    		Epithelial Tight Junctions0.36

    Pathway sources
    See GeneCards unified pathways
    Show all pathways

    2 EMD Millipore Pathways for F11R
        Cell adhesion Tight junctions
    Cell adhesion Endothelial cell contacts by junctional mechanisms

    3 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for F11R
        Sertoli-Sertoli Cell Junction Dynamics
    Epithelial Tight Junctions
    Transendothelial Migration of Leukocytes

    2 GeneGo (Thomson Reuters) Pathways for F11R
        Cell adhesion Endothelial cell contacts by junctional mechanisms
    Cell adhesion Tight junctions

    2 BioSystems Pathways for F11R 
        Integrins in angiogenesis
    Nectin adhesion pathway

    5/11        Reactome Pathways for F11R (see all 11)
        Hemostasis
    Integrin cell surface interactions
    Tight junction interactions
    Disassembly of tight junctions
    Signaling by TGF-beta Receptor Complex


    4         Kegg Pathways  (Kegg details for F11R):
        Cell adhesion molecules (CAMs)
    Tight junction
    Leukocyte transendothelial migration
    Epithelial cell signaling in Helicobacter pylori infection


    F11R for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for F11R

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/54 Interacting proteins for F11R (Q9Y6242, 3 ENSP000002897794) via UniProtKB, MINT, STRING, and/or I2D (see all 54)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    PARD3Q8TEW02, 3, ENSP000003639214MINT-4085346 MINT-4085691 I2D: score=4 STRING: ENSP00000363921
    CASKO149362, 3, ENSP000003674084MINT-58195 I2D: score=2 STRING: ENSP00000367408
    PRKCZQ055132, 3, ENSP000003678304MINT-4085708 I2D: score=2 STRING: ENSP00000367830
    PTPRBP234673, ENSP000003349284I2D: score=1 STRING: ENSP00000334928
    TJP1Q071573, ENSP000002815374I2D: score=1 STRING: ENSP00000281537
    About this table

    Gene Ontology (GO): 5/11 biological process terms (GO ID links to tree view) (see all 11):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006954inflammatory response TAS10395639
    GO:0007155cell adhesion IEA--
    GO:0007179transforming growth factor beta receptor signaling pathway TAS--
    GO:0007596blood coagulation TAS--
    GO:0019048virus-host interaction IEA--


    F11R for ontologies           About GeneDecksing



    Drugs & Compounds
    for F11R gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    F11R for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for F11R
    3 Novoseek chemical compound relationships for F11R gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    fibrinogen 16.3 1 12008956 (1)
    calcium 0 3 11120739 (1), 10852816 (1), 14528017 (1)
    serine 0 1 11120739 (1)

    Search CenterWatch for drugs/clinical trials and news about F11R / JAM1 

    Transcripts
    for F11R gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for F11R gene (5 alternative transcripts): 
    NM_016946.4  NM_144501.1  NM_144502.1  NM_144503.1  NM_144504.1  

    Unigene Cluster for F11R:

    F11 receptor
    Hs.517293  [show with all ESTs]
    Unigene Representative Sequence: NM_016946
    7 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000368026(uc010pjv.2 uc009wtt.3 uc010pjw.2 uc001fxf.4)
    ENST00000335772 ENST00000289779 ENST00000472573 ENST00000470694 ENST00000436182
    ENST00000537746

    miRNA
    Products:             		 OriGene 3'-UTR Clone: F11R
    Browse OriGene MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat F11R
    8/29 QIAGEN miScript miRNA Assays for microRNAs that regulate F11R (see all 29):
    hsa-miR-2052 hsa-miR-4291 hsa-miR-3910 hsa-miR-495 hsa-miR-875-3p hsa-miR-1321 hsa-miR-539 hsa-miR-520d-5p
    SwitchGear 3'UTR luciferase reporter plasmid: F11R 3' UTR sequence
    Inhib. RNA
    Products:             		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for F11R (see all 7)
    OriGene shRNA RFP: F11R
    OriGene siRNA: F11R
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat F11R
    Clone
    Products:             		 OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for F11R (see all 5)
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    GenScript: all cDNA clones in your preferred vector: F11R (NM_016946)
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat F11R 
    Primer
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    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat F11R
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat F11R
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat F11R

    Additional cDNA sequence: 

    AF154005.1 AF172398.2 AF207907.1 AK026665.1 AK075152.1 AK299487.1 AK304412.1 AL365518.1 
    AY358896.1 BC001533.2 BT020103.1 CR533512.1 

    24/37 DOTS entries (see all 37):

    DT.121464022  DT.101964034  DT.95172353  DT.100827531  DT.91967531  DT.317804  DT.121464000  DT.121464074 
    DT.99946969  DT.121463976  DT.97768628  DT.121463952  DT.121464027  DT.91775010  DT.121464048  DT.121464025 
    DT.91775016  DT.100827543  DT.121463964  DT.100827542  DT.121463973  DT.121464036  DT.95172344  DT.97806888 

    24/597 AceView cDNA sequences (see all 597):

    BU542666 AA411532 BG679730 BF727086 BC001699 BM786395 NM_144504 BE792267 
    AA877143 AA522896 AW510617 BC038219 AI282728 BE712547 BM727807 AA359412 
    BQ685315 BQ676666 AI925871 BM541282 BF916759 AW149882 AA780046 AI864718 

    GeneLoc Exon Structure

    5/18 Alternative Splicing Database (ASD) splice patterns (SP) for F11R (see all 18)    About this scheme

    ExUns: 1a · 1b · 1c · 1d · 1e ^ 2a · 2b · 2c ^ 3 ^ 4a · 4b ^ 5a · 5b · 5c ^ 6 ^ 7 ^ 8 ^ 9 ^ 10a · 10b · 10c · 10d ^ 11a · 11b · 11c · 11d ^
    SP1:                                                                                      -     -     -           -                 -                 -     -   
    SP2:                                -     -     -     -     -     -     -     -     -     -     -     -           -                 -                 -     -   
    SP3:                                                                                      -     -     -           -                 -     -     -     -     -   
    SP4:                                                                                            -     -           -                 -                 -     -   
    SP5:                                                                                                              -                 -                 -     -   

    ExUns: 12a · 12b · 12c ^ 13 ^ 14 ^ 15 ^ 16 ^ 17
    SP1:                                                
    SP2:                                                
    SP3:                                                
    SP4:                                                
    SP5:                                                


    ECgene alternative splicing isoforms for F11R

    Expression
    for F11R gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    F11R expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: GGGAAGCAGA

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    F11R expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    5 LifeMap In Vivo Development Anatomical Compartments/Cells 
    Tissue Anatomical Compartment CellCategory (developmental path)
    BrainChoroid PlexusMature Choroid Plexus CellsChoroid Plexus
    Gut TubeMidgutMidgut Endoderm CellsEndoderm
    Gut TubeMidgutGut Tube
    KidneyMetanephrosKidney
    LungTracheaLung
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization
    Stem Cell Differentiation: 1 LifeMap Cell 
    NameCategory
    PureStem™ progenitor Z1 (Embryonic Progenitor Cell)

    See F11R Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for F11R

    SOURCE GeneReport for Unigene cluster: Hs.517293
        SABiosciences Expression via Pathway-Focused PCR Arrays including F11R: 
              Tight Junctions in human mouse rat
              Cell Junction PathwayFinder in human mouse rat
              Epithelial to Mesenchymal Transition (EMT) in human mouse rat
              Inflammatory Response & Autoimmunity 384HT in human mouse rat

    Primer
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    Orthologs
    for F11R gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of chordates.

    Orthologs for F11R gene from 2/9 species (see all 9)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    African clawed frog
    (Xenopus laevis)    		 Amphibia LOC3986272 hypothetical protein LOC398627 77.17(n)    BC054305.1 
    zebrafish
    (Danio rerio)    		 Actinopterygii f11r1 F11 receptor 53.59(n)
    45(a)    		   323696  NM_001004667.2  NP_001004667.1 


    ENSEMBL Gene Tree for F11R (if available)
    TreeFam Gene Tree for F11R (if available) 

    Paralogs
    for F11R gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for F11R gene
    CLMP2  ESAM2  VSIG82  GPA332  JAM22  VSIG12  CXADR2  VSIG22  
    C1orf2042  IGSF112  JAM32  
    2 SIMAP similar genes for F11R using alignment to 5 protein entries:     JAM1_HUMAN (see all proteins):
    JAM2    JAM3

    F11R for paralogs           About GeneDecksing



    Genomic Variants
    for F11R gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/488 NCBI SNPs in F11R are shown (see all 488)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 1 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs24810761,2
    		C,--160964697(+) TTTAAG/AACCAG 1 -- ds50018Minor allele frequency- A:0.00NA WA CSA 15
    rs1434261771,2
    		--160964722(+) TGAAAA/CCCTGT 1 -- ds50010--------
    rs727128541,2
    		C,F,--160964744(+) CTATTA/TAAAAA 1 -- ds50012Minor allele frequency- T:0.27NA EA 240
    rs1460672291,2
    		--160964755(+) AAAATC/TATCCG 1 -- ds50010--------
    rs1114629391,2
    		C,--160964882(+) GTGAT-/AAGAGT 1 -- ds50011Minor allele frequency- A:0.50CSA 2
    rs1130095971,2
    		C,--160964883(+) GGTGAC/TAGAGT 1 -- ds50011Minor allele frequency- T:0.50NA 2
    rs618036641,2
    		C,F,--160964983(+) AAGGGG/TTAATA 1 -- ds50015Minor allele frequency- T:0.20NA WA EA 362
    rs1507800071,2
    		--160965031(+) AAATTA/GTTGTT 1 -- ut310--------
    rs1915241371,2
    		--160965266(+) TGGCCA/GGGTGC 1 -- ut310--------
    rs1121480501,2
    		C,--160965306(+) TGGGAG/AGCCGA 1 -- ut311Minor allele frequency- A:0.50WA 2

    HapMap Linkage Disequilibrium report for F11R (160965001 - 161008784 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for F11R: --

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    Disorders / Diseases
    for F11R gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    F11R for disorders           About GeneDecksing

    OMIM gene information: 605721    OMIM disorders: --

    20/22 diseases for F11R (see all 22):    About MalaCards
    occupational dermatitis    familial combined hyperlipidemia    clear cell renal cell carcinoma    renal cell carcinoma
    inflammatory bowel disease    hyperlipidemia    thrombosis    multiple sclerosis
    dermatitis    myeloid leukemia    endometrial carcinoma    hepatitis b
    atherosclerosis    colorectal cancer    carcinoma    breast cancer
    hepatitis    obesity    hypertension    leukemia

    5 Novoseek disease relationships for F11R gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    thrombosis 27.9 1 17481380 (1)
    atherosclerosis 11.1 1 17964041 (1)
    necrosis 7.38 1 15886398 (1)
    inflammation 0 2 17481380 (1), 17615384 (1)
    tumors 0 1 15886398 (1)

    Human Genome Epidemiology (HuGE) Navigator: F11R (11 documents)

    Export disorders for F11R gene to outside databases

    Publications
    for F11R gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for F11R gene, integrated from 9 sources (see all 127):
    (articles sorted by number of sources associating them with F11R)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Combined treatment of TNF-alpha and IFN-gamma causes redistribution of junctional adhesion molecule in human endothelial cells. (PubMed id 10395639)1, 2, 3 Ozaki H.... Kita T. (1999)
    2. Mechanisms of platelet activation by a stimulatory antibody: cross- linking of a novel platelet receptor for monoclonal antibody F11 with the Fc gamma RII receptor. (PubMed id 7646439)1, 2, 3 Naik U.P.... Kornecki E. (1995)
    3. Characterization and chromosomal localization of JAM-1, a platelet receptor for a stimulatory monoclonal antibody. (PubMed id 11171323)1, 2, 9 Naik U.P.... Spychala J. (2001)
    4. Cloning of the human platelet F11 receptor: a cell adhesion molecule member of the immunoglobulin superfamily involved in platelet aggregation. (PubMed id 10753840)1, 2, 9 Sobocka M.B.... Kornecki E. (2000)
    5. Signal peptide prediction based on analysis of experimentally verified cleavage sites. (PubMed id 15340161)1, 2 Zhang Z. and Henzel W.J. (2004)
    6. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    7. Crystal structure of human junctional adhesion molecule 1: implications for reovirus binding. (PubMed id 12697893)1, 2 Prota A.E.... Stehle T. (2003)
    8. Leukocyte-endothelial-cell interactions in leukocyte transmigration and the inflammatory response. (PubMed id 12810109)1, 2 Muller W.A. (2003)
    9. Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides. (PubMed id 12665801)1, 2 Gevaert K.... Vandekerckhove J. (2003)
    10. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PubMed id 12975309)1, 2 Clark H.F.... Gray A.M. (2003)

    External Searches for F11R gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing F11R gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 50848 HGNC: 14685 AceView: F11R Ensembl:ENSG00000158769 euGenes: HUgn50848
    ECgene: F11R Kegg: 50848 H-InvDB: F11R

    Other Databases showing F11R gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing F11R gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for F11R Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for F11R gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for F11R gene:
    Search GeneIP for patents involving F11R

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    About This Section

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