Free for academic non-profit institutions. Other users need a Commercial license

Aliases for F11R Gene

Aliases for F11R Gene

  • F11 Receptor 2 3 5
  • Junctional Adhesion Molecule 1 2 3 4
  • Platelet Adhesion Molecule 1 3 4
  • Platelet F11 Receptor 3 4
  • PAM-1 3 4
  • JAM1 3 4
  • JCAM 3 4
  • Junctional Adhesion Molecule A 3
  • CD321 Antigen 4
  • CD321 3
  • JAM-1 4
  • JAM-A 4
  • JAMA 3
  • JAM 3
  • KAT 3

External Ids for F11R Gene

Previous HGNC Symbols for F11R Gene

  • JAM1

Previous GeneCards Identifiers for F11R Gene

  • GC01M156698
  • GC01M157743
  • GC01M158182
  • GC01M157779
  • GC01M159231
  • GC01M132321

Summaries for F11R Gene

Entrez Gene Summary for F11R Gene

  • Tight junctions represent one mode of cell-to-cell adhesion in epithelial or endothelial cell sheets, forming continuous seals around cells and serving as a physical barrier to prevent solutes and water from passing freely through the paracellular space. The protein encoded by this immunoglobulin superfamily gene member is an important regulator of tight junction assembly in epithelia. In addition, the encoded protein can act as (1) a receptor for reovirus, (2) a ligand for the integrin LFA1, involved in leukocyte transmigration, and (3) a platelet receptor. Multiple 5' alternatively spliced variants, encoding the same protein, have been identified but their biological validity has not been established. [provided by RefSeq, Jul 2008]

GeneCards Summary for F11R Gene

F11R (F11 Receptor) is a Protein Coding gene. Diseases associated with F11R include Mednik Syndrome. Among its related pathways are Cell surface interactions at the vascular wall and Blood-Brain Barrier and Immune Cell Transmigration: VCAM-1/CD106 Signaling Pathways. GO annotations related to this gene include PDZ domain binding. An important paralog of this gene is JAM3.

UniProtKB/Swiss-Prot for F11R Gene

  • Seems to play a role in epithelial tight junction formation. Appears early in primordial forms of cell junctions and recruits PARD3 (PubMed:11489913). The association of the PARD6-PARD3 complex may prevent the interaction of PARD3 with JAM1, thereby preventing tight junction assembly (By similarity). Plays a role in regulating monocyte transmigration involved in integrity of epithelial barrier (By similarity). Ligand for integrin alpha-L/beta-2 involved in memory T-cell and neutrophil transmigration (PubMed:11812992). Involved in platelet activation (PubMed:10753840).

  • (Microbial infection) Acts as a receptor for Mammalian reovirus sigma-1.

  • (Microbial infection) Acts as a receptor for Human Rotavirus strain Wa.

Gene Wiki entry for F11R Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for F11R Gene

Genomics for F11R Gene

Regulatory Elements for F11R Gene

Enhancers for F11R Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH01F161037 1 ENCODE 43.9 -17.4 -17406 2.2 HDGF ATF1 PKNOX1 SIN3A ZNF2 YY1 ZNF121 ZNF766 GLIS2 ELK1 F11R TSTD1 LOC105371471 ARHGAP30 NECTIN4 ENSG00000232879 ENSG00000270149
GH01F161079 1.6 FANTOM5 Ensembl ENCODE 26.4 -63.4 -63421 11.3 PKNOX1 ATF1 BRCA1 ZNF121 GLIS2 FOS ZNF263 SP3 ZHX2 NCOA1 F11R NECTIN4 DUSP12 TSTD1 NCSTN USF1 LOC105371471
GH01F160989 1.3 Ensembl ENCODE 19.9 +31.0 30958 1.2 PKNOX1 ATF1 ARNT CREB3L1 WRNIP1 BRCA1 ZNF2 ZNF121 GTF3C2 ELK1 F11R ENSG00000232879 ENSG00000228606 TSTD1 ARHGAP30 CD48 DUSP12 SLAMF7 ENSG00000228863 SLAMF1
GH01F161066 1.5 FANTOM5 ENCODE 16.1 -47.3 -47267 5.1 HDGF PKNOX1 WRNIP1 SIN3A YY1 GLIS2 ELK1 ZNF143 ZNF207 SP3 FCGR2A TSTD1 DUSP12 ENSG00000228606 ARHGAP30 F11R DEDD ATF6 NECTIN4 ENSG00000232879
GH01F161011 1.6 FANTOM5 ENCODE 10.5 +4.1 4135 11.7 MLX CREB3L1 ZFP64 FEZF1 DMAP1 YY1 SLC30A9 ZNF143 ZNF263 SP3 DUSP12 ARHGAP30 TSTD1 ENSG00000228606 FCGR2A USF1 RPSAP18 CD48 DEDD KLHDC9
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around F11R on UCSC Golden Path with GeneCards custom track

Promoters for F11R Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001525262 848 2601 HDGF PKNOX1 ARNT CREB3L1 WRNIP1 ARID4B SIN3A FEZF1 ZNF2 YY1

Genomic Location for F11R Gene

Chromosome:
1
Start:
160,995,211 bp from pter
End:
161,021,348 bp from pter
Size:
26,138 bases
Orientation:
Minus strand

Genomic View for F11R Gene

Genes around F11R on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
F11R Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for F11R Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for F11R Gene

Proteins for F11R Gene

  • Protein details for F11R Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9Y624-JAM1_HUMAN
    Recommended name:
    Junctional adhesion molecule A
    Protein Accession:
    Q9Y624
    Secondary Accessions:
    • B7Z941

    Protein attributes for F11R Gene

    Size:
    299 amino acids
    Molecular mass:
    32583 Da
    Quaternary structure:
    • Interacts with the ninth PDZ domain of MPDZ (PubMed:11489913). Interacts with the first PDZ domain of PARD3 (PubMed:11489913). The association between PARD3 and PARD6B probably disrupts this interaction (By similarity). Interacts with ITGAL (via I-domain) (PubMed:15528364).
    • (Microbial infection) Interacts with Mammalian reovirus sigma-1 capsid protein.
    • (Microbial infection) Interacts with Human Rotavirus strain Wa vp4 capsid protein.

    Three dimensional structures from OCA and Proteopedia for F11R Gene

    Alternative splice isoforms for F11R Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for F11R Gene

Post-translational modifications for F11R Gene

Other Protein References for F11R Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for F11R Gene

Domains & Families for F11R Gene

Graphical View of Domain Structure for InterPro Entry

Q9Y624

UniProtKB/Swiss-Prot:

JAM1_HUMAN :
  • The Ig-like V-type 2 domain is necessary and sufficient for interaction with integrin alpha-L/beta-2.
  • Belongs to the immunoglobulin superfamily.
Domain:
  • The Ig-like V-type 2 domain is necessary and sufficient for interaction with integrin alpha-L/beta-2.
  • Contains 2 Ig-like V-type (immunoglobulin-like) domains.
Family:
  • Belongs to the immunoglobulin superfamily.
genes like me logo Genes that share domains with F11R: view

Function for F11R Gene

Molecular function for F11R Gene

UniProtKB/Swiss-Prot Function:
Seems to play a role in epithelial tight junction formation. Appears early in primordial forms of cell junctions and recruits PARD3 (PubMed:11489913). The association of the PARD6-PARD3 complex may prevent the interaction of PARD3 with JAM1, thereby preventing tight junction assembly (By similarity). Plays a role in regulating monocyte transmigration involved in integrity of epithelial barrier (By similarity). Ligand for integrin alpha-L/beta-2 involved in memory T-cell and neutrophil transmigration (PubMed:11812992). Involved in platelet activation (PubMed:10753840).
UniProtKB/Swiss-Prot Function:
(Microbial infection) Acts as a receptor for Mammalian reovirus sigma-1.
UniProtKB/Swiss-Prot Function:
(Microbial infection) Acts as a receptor for Human Rotavirus strain Wa.

Gene Ontology (GO) - Molecular Function for F11R Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001618 virus receptor activity IEA --
GO:0005515 protein binding IPI 16189514
GO:0030165 PDZ domain binding IPI 23885123
GO:0098641 cadherin binding involved in cell-cell adhesion IDA 25468996
genes like me logo Genes that share ontologies with F11R: view
genes like me logo Genes that share phenotypes with F11R: view

Animal Models for F11R Gene

MGI Knock Outs for F11R:

Animal Model Products

  • Taconic Biosciences Mouse Models for F11R

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for F11R

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for F11R Gene

Localization for F11R Gene

Subcellular locations from UniProtKB/Swiss-Prot for F11R Gene

Cell junction, tight junction. Cell membrane; Single-pass type I membrane protein. Note=Localized at tight junctions of both epithelial and endothelial cells. {ECO:0000269 PubMed:11171323}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for F11R gene
Compartment Confidence
plasma membrane 5
extracellular 5
cytoskeleton 3
endosome 2
peroxisome 1
nucleus 1
endoplasmic reticulum 1
cytosol 1
lysosome 1
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for F11R Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0005911 cell-cell junction TAS 10395639
GO:0005913 cell-cell adherens junction IDA 25468996
GO:0005923 bicellular tight junction IEA,IDA 23885123
GO:0015630 microtubule cytoskeleton IDA --
genes like me logo Genes that share ontologies with F11R: view

Pathways & Interactions for F11R Gene

genes like me logo Genes that share pathways with F11R: view

SIGNOR curated interactions for F11R Gene

Other effect:

Gene Ontology (GO) - Biological Process for F11R Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001817 regulation of cytokine production IEA --
GO:0006954 inflammatory response TAS 10395639
GO:0007155 cell adhesion IEA --
GO:0007179 transforming growth factor beta receptor signaling pathway TAS --
GO:0009314 response to radiation IEA --
genes like me logo Genes that share ontologies with F11R: view

Drugs & Compounds for F11R Gene

(2) Drugs for F11R Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(1) Additional Compounds for F11R Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with F11R: view

Transcripts for F11R Gene

Unigene Clusters for F11R Gene

F11 receptor:
Representative Sequences:

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for F11R

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for F11R Gene

ExUns: 1a · 1b · 1c · 1d · 1e ^ 2a · 2b · 2c ^ 3 ^ 4a · 4b ^ 5a · 5b · 5c ^ 6 ^ 7 ^ 8 ^ 9 ^ 10a · 10b · 10c · 10d ^ 11a · 11b · 11c · 11d ^
SP1: - - - - - - -
SP2: - - - - - - - - - - - - - - - -
SP3: - - - - - - - - -
SP4: - - - - - -
SP5: - - - -
SP6: - - - - -
SP7: - - -
SP8: - -
SP9: - - - - - - - - - - - - - -
SP10: -
SP11:
SP12: - - -
SP13: - - - -
SP14: - - -
SP15: - -
SP16:
SP17: - - -
SP18: - -

ExUns: 12a · 12b · 12c ^ 13 ^ 14 ^ 15 ^ 16 ^ 17
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:
SP14:
SP15:
SP16:
SP17:
SP18:

Relevant External Links for F11R Gene

GeneLoc Exon Structure for
F11R
ECgene alternative splicing isoforms for
F11R

Expression for F11R Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for F11R Gene

Protein differential expression in normal tissues from HIPED for F11R Gene

This gene is overexpressed in Nasal epithelium (39.8) and Peripheral blood mononuclear cells (7.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for F11R Gene



Protein tissue co-expression partners for F11R Gene

NURSA nuclear receptor signaling pathways regulating expression of F11R Gene:

F11R

SOURCE GeneReport for Unigene cluster for F11R Gene:

Hs.517293

mRNA Expression by UniProt/SwissProt for F11R Gene:

Q9Y624-JAM1_HUMAN
Tissue specificity: Expressed in endothelium, epithelium and leukocytes (at protein level).
genes like me logo Genes that share expression patterns with F11R: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for F11R Gene

Orthologs for F11R Gene

This gene was present in the common ancestor of chordates.

Orthologs for F11R Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia F11R 34 35
  • 100 (n)
dog
(Canis familiaris)
Mammalia F11R 34 35
  • 83.7 (n)
cow
(Bos Taurus)
Mammalia F11R 34 35
  • 81.77 (n)
rat
(Rattus norvegicus)
Mammalia F11r 34
  • 79.19 (n)
mouse
(Mus musculus)
Mammalia F11r 34 16 35
  • 77.52 (n)
oppossum
(Monodelphis domestica)
Mammalia F11R 35
  • 65 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia LOC398627 34
zebrafish
(Danio rerio)
Actinopterygii f11r 34 35
  • 54.36 (n)
f11rl 35
  • 29 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 24 (a)
OneToMany
Species where no ortholog for F11R was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for F11R Gene

ENSEMBL:
Gene Tree for F11R (if available)
TreeFam:
Gene Tree for F11R (if available)

Paralogs for F11R Gene

Paralogs for F11R Gene

(2) SIMAP similar genes for F11R Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with F11R: view

Variants for F11R Gene

Sequence variations from dbSNP and Humsavar for F11R Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs10082222 -- 160,996,832(+) AAGCT(A/C)TACTT utr-variant-3-prime
rs1044478 -- 160,997,173(-) GAGCC(A/G)GACAG utr-variant-3-prime
rs1062826 -- 160,998,215(-) GAAGC(C/G)AAAAG utr-variant-3-prime
rs1062827 -- 160,997,054(-) GACAA(A/G)TAAAG utr-variant-3-prime
rs10644902 -- 161,005,418(+) GTGAC(-/CCTT)CCACC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for F11R Gene

Variant ID Type Subtype PubMed ID
esv2667660 CNV deletion 23128226
esv3578229 CNV loss 25503493
esv3587722 CNV loss 21293372
esv3587723 CNV gain 21293372
nsv548058 CNV loss 21841781

Variation tolerance for F11R Gene

Residual Variation Intolerance Score: 29.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.77; 16.29% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for F11R Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
F11R

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for F11R Gene

Disorders for F11R Gene

MalaCards: The human disease database

(1) MalaCards diseases for F11R Gene - From: DISEASES

Disorder Aliases PubMed IDs
mednik syndrome
  • mental retardation, enteropathy, deafness, peripheral neuropathy, ichthyosis, and keratoderma
- elite association - COSMIC cancer census association via MalaCards
Search F11R in MalaCards View complete list of genes associated with diseases

Relevant External Links for F11R

Genetic Association Database (GAD)
F11R
Human Genome Epidemiology (HuGE) Navigator
F11R
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
F11R
genes like me logo Genes that share disorders with F11R: view

No data available for UniProtKB/Swiss-Prot and Genatlas for F11R Gene

Publications for F11R Gene

  1. Association of F11 receptor gene polymorphisms with central obesity and blood pressure. (PMID: 18067551) Ong K.L. … Cheung B.M. (J. Intern. Med. 2008) 3 22 46 64
  2. Characterization and chromosomal localization of JAM-1, a platelet receptor for a stimulatory monoclonal antibody. (PMID: 11171323) Naik U.P. … Spychala J. (J. Cell Sci. 2001) 3 4 22 64
  3. Cloning of the human platelet F11 receptor: a cell adhesion molecule member of the immunoglobulin superfamily involved in platelet aggregation. (PMID: 10753840) Sobocka M.B. … Kornecki E. (Blood 2000) 3 4 22 64
  4. Combined treatment of TNF-alpha and IFN-gamma causes redistribution of junctional adhesion molecule in human endothelial cells. (PMID: 10395639) Ozaki H. … Kita T. (J. Immunol. 1999) 2 3 4 64
  5. Mechanisms of platelet activation by a stimulatory antibody: cross- linking of a novel platelet receptor for monoclonal antibody F11 with the Fc gamma RII receptor. (PMID: 7646439) Naik U.P. … Kornecki E. (Biochem. J. 1995) 2 3 4 64

Products for F11R Gene

  • Cloud-Clone Corp. Antibodies for F11R
  • Cloud-Clone Corp. Proteins for F11R
  • Cloud-Clone Corp Assay Kits for F11R

Sources for F11R Gene

Content
Loading form....