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Aliases for F11R Gene

Aliases for F11R Gene

  • F11 Receptor 2 3 5
  • Junctional Adhesion Molecule 1 2 3 4
  • Platelet Adhesion Molecule 1 3 4
  • Platelet F11 Receptor 3 4
  • PAM-1 3 4
  • JAM1 3 4
  • JCAM 3 4
  • CD321 Antigen 4
  • CD321 3
  • JAM-1 4
  • JAM-A 4
  • JAMA 3
  • JAM 3
  • KAT 3

External Ids for F11R Gene

Previous HGNC Symbols for F11R Gene

  • JAM1

Previous GeneCards Identifiers for F11R Gene

  • GC01M156698
  • GC01M157743
  • GC01M158182
  • GC01M157779
  • GC01M159231
  • GC01M132321

Summaries for F11R Gene

Entrez Gene Summary for F11R Gene

  • Tight junctions represent one mode of cell-to-cell adhesion in epithelial or endothelial cell sheets, forming continuous seals around cells and serving as a physical barrier to prevent solutes and water from passing freely through the paracellular space. The protein encoded by this immunoglobulin superfamily gene member is an important regulator of tight junction assembly in epithelia. In addition, the encoded protein can act as (1) a receptor for reovirus, (2) a ligand for the integrin LFA1, involved in leukocyte transmigration, and (3) a platelet receptor. Multiple 5' alternatively spliced variants, encoding the same protein, have been identified but their biological validity has not been established. [provided by RefSeq, Jul 2008]

GeneCards Summary for F11R Gene

F11R (F11 Receptor) is a Protein Coding gene. Diseases associated with F11R include Mednik Syndrome. Among its related pathways are Cell junction organization and ECM-receptor interaction. GO annotations related to this gene include PDZ domain binding. An important paralog of this gene is JAM2.

UniProtKB/Swiss-Prot for F11R Gene

  • Seems to play a role in epithelial tight junction formation. Appears early in primordial forms of cell junctions and recruits PARD3. The association of the PARD6-PARD3 complex may prevent the interaction of PARD3 with JAM1, thereby preventing tight junction assembly (By similarity). Plays a role in regulating monocyte transmigration involved in integrity of epithelial barrier. Involved in platelet activation.

  • (Microbial infection) Acts as a receptor for Mammalian reovirus sigma-1 (PubMed:11239401). Acts as a receptor for Human Rotavirus strain Wa (PubMed:25481868).

Gene Wiki entry for F11R Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for F11R Gene

Genomics for F11R Gene

Regulatory Elements for F11R Gene

Enhancers for F11R Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around F11R on UCSC Golden Path with GeneCards custom track

Promoters for F11R Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around F11R on UCSC Golden Path with GeneCards custom track

Genomic Location for F11R Gene

Chromosome:
1
Start:
160,995,211 bp from pter
End:
161,021,348 bp from pter
Size:
26,138 bases
Orientation:
Minus strand

Genomic View for F11R Gene

Genes around F11R on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
F11R Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for F11R Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for F11R Gene

Proteins for F11R Gene

  • Protein details for F11R Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9Y624-JAM1_HUMAN
    Recommended name:
    Junctional adhesion molecule A
    Protein Accession:
    Q9Y624
    Secondary Accessions:
    • B7Z941

    Protein attributes for F11R Gene

    Size:
    299 amino acids
    Molecular mass:
    32583 Da
    Quaternary structure:
    • Interacts with the ninth PDZ domain of MPDZ. Interacts with the first PDZ domain of PARD3. The association between PARD3 and PARD6B probably disrupts this interaction (By similarity).
    • (Microbial infection) Interacts with Mammalian reovirus sigma-1 capsid protein.
    • (Microbial infection) Interacts with Human Rotavirus strain Wa vp4 capsid protein.

    Three dimensional structures from OCA and Proteopedia for F11R Gene

    Alternative splice isoforms for F11R Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for F11R Gene

Proteomics data for F11R Gene at MOPED

Post-translational modifications for F11R Gene

Other Protein References for F11R Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for F11R Gene

Domains & Families for F11R Gene

Graphical View of Domain Structure for InterPro Entry

Q9Y624

UniProtKB/Swiss-Prot:

JAM1_HUMAN :
  • Contains 2 Ig-like V-type (immunoglobulin-like) domains.
  • Belongs to the immunoglobulin superfamily.
Domain:
  • Contains 2 Ig-like V-type (immunoglobulin-like) domains.
Family:
  • Belongs to the immunoglobulin superfamily.
genes like me logo Genes that share domains with F11R: view

Function for F11R Gene

Molecular function for F11R Gene

UniProtKB/Swiss-Prot Function:
Seems to play a role in epithelial tight junction formation. Appears early in primordial forms of cell junctions and recruits PARD3. The association of the PARD6-PARD3 complex may prevent the interaction of PARD3 with JAM1, thereby preventing tight junction assembly (By similarity). Plays a role in regulating monocyte transmigration involved in integrity of epithelial barrier. Involved in platelet activation.
UniProtKB/Swiss-Prot Function:
(Microbial infection) Acts as a receptor for Mammalian reovirus sigma-1 (PubMed:11239401). Acts as a receptor for Human Rotavirus strain Wa (PubMed:25481868).

Gene Ontology (GO) - Molecular Function for F11R Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0030165 PDZ domain binding IPI 23885123
genes like me logo Genes that share ontologies with F11R: view
genes like me logo Genes that share phenotypes with F11R: view

Animal Models for F11R Gene

MGI Knock Outs for F11R:

Animal Model Products

  • Taconic Biosciences Mouse Models for F11R

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for F11R Gene

Localization for F11R Gene

Subcellular locations from UniProtKB/Swiss-Prot for F11R Gene

Cell junction, tight junction. Cell membrane; Single-pass type I membrane protein. Note=Localized at tight junctions of both epithelial and endothelial cells.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for F11R Gene COMPARTMENTS Subcellular localization image for F11R gene
Compartment Confidence
cytoskeleton 5
extracellular 5
plasma membrane 5
endosome 2
cytosol 1
endoplasmic reticulum 1
golgi apparatus 1
lysosome 1
nucleus 1
peroxisome 1
vacuole 1

Gene Ontology (GO) - Cellular Components for F11R Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0030054 cell junction TAS --
GO:0031410 cytoplasmic vesicle IEA --
genes like me logo Genes that share ontologies with F11R: view

Pathways & Interactions for F11R Gene

genes like me logo Genes that share pathways with F11R: view

SIGNOR curated interactions for F11R Gene

Other effect:

Gene Ontology (GO) - Biological Process for F11R Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006954 inflammatory response TAS 10395639
GO:0007155 cell adhesion IEA --
GO:0007596 blood coagulation TAS --
GO:0009314 response to radiation IEA --
GO:0030198 extracellular matrix organization TAS --
genes like me logo Genes that share ontologies with F11R: view

Drugs & Compounds for F11R Gene

(2) Drugs for F11R Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(1) Additional Compounds for F11R Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with F11R: view

Transcripts for F11R Gene

Unigene Clusters for F11R Gene

F11 receptor:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for F11R Gene

ExUns: 1a · 1b · 1c · 1d · 1e ^ 2a · 2b · 2c ^ 3 ^ 4a · 4b ^ 5a · 5b · 5c ^ 6 ^ 7 ^ 8 ^ 9 ^ 10a · 10b · 10c · 10d ^ 11a · 11b · 11c · 11d ^
SP1: - - - - - - -
SP2: - - - - - - - - - - - - - - - -
SP3: - - - - - - - - -
SP4: - - - - - -
SP5: - - - -
SP6: - - - - -
SP7: - - -
SP8: - -
SP9: - - - - - - - - - - - - - -
SP10: -
SP11:
SP12: - - -
SP13: - - - -
SP14: - - -
SP15: - -
SP16:
SP17: - - -
SP18: - -

ExUns: 12a · 12b · 12c ^ 13 ^ 14 ^ 15 ^ 16 ^ 17
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:
SP14:
SP15:
SP16:
SP17:
SP18:

Relevant External Links for F11R Gene

GeneLoc Exon Structure for
F11R
ECgene alternative splicing isoforms for
F11R

Expression for F11R Gene

mRNA expression in normal human tissues for F11R Gene

Protein differential expression in normal tissues from HIPED for F11R Gene

This gene is overexpressed in Nasal epithelium (39.8) and Peripheral blood mononuclear cells (7.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MOPED, and MaxQB for F11R Gene



SOURCE GeneReport for Unigene cluster for F11R Gene Hs.517293

genes like me logo Genes that share expression patterns with F11R: view

Protein tissue co-expression partners for F11R Gene

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for F11R Gene

Orthologs for F11R Gene

This gene was present in the common ancestor of chordates.

Orthologs for F11R Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia F11R 35
  • 81.77 (n)
  • 74.83 (a)
F11R 36
  • 74 (a)
OneToOne
dog
(Canis familiaris)
Mammalia F11R 35
  • 83.7 (n)
  • 81.52 (a)
F11R 36
  • 75 (a)
OneToOne
mouse
(Mus musculus)
Mammalia F11r 35
  • 77.52 (n)
  • 69.13 (a)
F11r 16
F11r 36
  • 67 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia F11R 35
  • 100 (n)
  • 100 (a)
F11R 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia F11r 35
  • 79.19 (n)
  • 72.48 (a)
oppossum
(Monodelphis domestica)
Mammalia F11R 36
  • 65 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia LOC398627 35
zebrafish
(Danio rerio)
Actinopterygii f11r 35
  • 54.36 (n)
  • 45.77 (a)
f11r 36
  • 37 (a)
OneToMany
f11rl 36
  • 29 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 24 (a)
OneToMany
Species with no ortholog for F11R:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for F11R Gene

ENSEMBL:
Gene Tree for F11R (if available)
TreeFam:
Gene Tree for F11R (if available)

Paralogs for F11R Gene

Paralogs for F11R Gene

(2) SIMAP similar genes for F11R Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with F11R: view

Variants for F11R Gene

Sequence variations from dbSNP and Humsavar for F11R Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs836 -- 160,998,434(+) TTCCC(A/G)CTCTA utr-variant-3-prime
rs993 -- 160,998,419(+) CGCTC(A/G/T)AGCCT utr-variant-3-prime
rs11624 -- 160,998,043(+) ACCAC(C/T)ATGCC utr-variant-3-prime
rs790055 -- 161,001,356(-) CTCCT(C/T)AGGCT intron-variant
rs790056 -- 160,999,795(-) TAGGT(A/G)CCGTG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for F11R Gene

Variant ID Type Subtype PubMed ID
esv2667660 CNV Deletion 23128226

Variation tolerance for F11R Gene

Residual Variation Intolerance Score: 29.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.77; 16.29% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for F11R Gene

Disorders for F11R Gene

MalaCards: The human disease database

(1) MalaCards diseases for F11R Gene - From: DISEASES

Disorder Aliases PubMed IDs
mednik syndrome
  • erythrokeratodermia variabilis 3
- elite association - COSMIC cancer census association via MalaCards
Search F11R in MalaCards View complete list of genes associated with diseases

Relevant External Links for F11R

Genetic Association Database (GAD)
F11R
Human Genome Epidemiology (HuGE) Navigator
F11R
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
F11R
genes like me logo Genes that share disorders with F11R: view

No data available for UniProtKB/Swiss-Prot and Genatlas for F11R Gene

Publications for F11R Gene

  1. Combined treatment of TNF-alpha and IFN-gamma causes redistribution of junctional adhesion molecule in human endothelial cells. (PMID: 10395639) Ozaki H. … Kita T. (J. Immunol. 1999) 2 3 4 67
  2. Junctional adhesion molecule A interacts with Afadin and PDZ-GEF2 to activate Rap1A, regulate beta1 integrin levels, and enhance cell migration. (PMID: 19176753) Severson E.A. … Parkos C.A. (Mol. Biol. Cell 2009) 3 23
  3. Elevated plasma level of soluble F11 receptor/junctional adhesion molecule-A (F11R/JAM-A) in hypertension. (PMID: 19214165) Ong K.L. … Cheung B.M. (Am. J. Hypertens. 2009) 3 23
  4. Induction of JAM-A during differentiation of human THP-1 dendritic cells. (PMID: 19748485) Ogasawara N. … Sawada N. (Biochem. Biophys. Res. Commun. 2009) 3 23
  5. Expression of junctional adhesion molecules on the human lymphatic endothelium. (PMID: 17822725) Ueki T. … Sawa Y. (Microvasc. Res. 2008) 3 23

Products for F11R Gene

Sources for F11R Gene

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