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Aliases for F11R Gene

Aliases for F11R Gene

  • F11 Receptor 2 3 5
  • Junctional Adhesion Molecule 1 2 3 4
  • Platelet Adhesion Molecule 1 3 4
  • Platelet F11 Receptor 3 4
  • PAM-1 3 4
  • JAM1 3 4
  • JCAM 3 4
  • Junctional Adhesion Molecule A 3
  • CD321 Antigen 4
  • CD321 3
  • JAM-1 4
  • JAM-A 4
  • JAMA 3
  • JAM 3
  • KAT 3

External Ids for F11R Gene

Previous HGNC Symbols for F11R Gene

  • JAM1

Previous GeneCards Identifiers for F11R Gene

  • GC01M156698
  • GC01M157743
  • GC01M158182
  • GC01M157779
  • GC01M159231
  • GC01M132321

Summaries for F11R Gene

Entrez Gene Summary for F11R Gene

  • Tight junctions represent one mode of cell-to-cell adhesion in epithelial or endothelial cell sheets, forming continuous seals around cells and serving as a physical barrier to prevent solutes and water from passing freely through the paracellular space. The protein encoded by this immunoglobulin superfamily gene member is an important regulator of tight junction assembly in epithelia. In addition, the encoded protein can act as (1) a receptor for reovirus, (2) a ligand for the integrin LFA1, involved in leukocyte transmigration, and (3) a platelet receptor. Multiple 5' alternatively spliced variants, encoding the same protein, have been identified but their biological validity has not been established. [provided by RefSeq, Jul 2008]

GeneCards Summary for F11R Gene

F11R (F11 Receptor) is a Protein Coding gene. Diseases associated with F11R include Mental Retardation, Enteropathy, Deafness, Peripheral Neuropathy, Ichthyosis, And Keratoderma. Among its related pathways are Response to elevated platelet cytosolic Ca2+ and Blood-Brain Barrier and Immune Cell Transmigration: VCAM-1/CD106 Signaling Pathways. Gene Ontology (GO) annotations related to this gene include PDZ domain binding. An important paralog of this gene is JAM2.

UniProtKB/Swiss-Prot for F11R Gene

  • Seems to play a role in epithelial tight junction formation. Appears early in primordial forms of cell junctions and recruits PARD3 (PubMed:11489913). The association of the PARD6-PARD3 complex may prevent the interaction of PARD3 with JAM1, thereby preventing tight junction assembly (By similarity). Plays a role in regulating monocyte transmigration involved in integrity of epithelial barrier (By similarity). Ligand for integrin alpha-L/beta-2 involved in memory T-cell and neutrophil transmigration (PubMed:11812992). Involved in platelet activation (PubMed:10753840).

  • (Microbial infection) Acts as a receptor for Mammalian reovirus sigma-1.

  • (Microbial infection) Acts as a receptor for Human Rotavirus strain Wa.

Gene Wiki entry for F11R Gene

Additional gene information for F11R Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for F11R Gene

Genomics for F11R Gene

GeneHancer (GH) Regulatory Elements for F11R Gene

Promoters and enhancers for F11R Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH01I161037 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE dbSUPER 43.9 -17.4 -17405 2.2 HDGF PKNOX1 SIN3A ZNF2 YY1 GLIS2 ZNF143 RUNX3 SP3 GLIS1 TSTD1 ENSG00000270149 F11R LOC105371471 ARHGAP30 NECTIN4 ENSG00000232879 USF1
GH01I161079 Promoter/Enhancer 2.1 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 26.4 -63.4 -63405 11.2 PKNOX1 CLOCK ATF1 NEUROD1 SIN3A BRCA1 GLIS2 ATF7 FOS ZNF263 NECTIN4 LOC105371471 F11R TSTD1 NCSTN USF1
GH01I161066 Promoter/Enhancer 2.4 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 16.1 -47.3 -47267 5.1 HDGF PKNOX1 BMI1 ZBTB40 KLF5 IRF4 ZNF207 ZNF143 ATF7 ETV6 ARHGAP30 FCGR2A TSTD1 DUSP12 USP21 PPOX F11R DEDD NECTIN4 ENSG00000232879
GH01I160989 Enhancer 1.4 Ensembl ENCODE dbSUPER 19.9 +31.0 30963 1.2 PKNOX1 SMAD1 FOXA2 ARNT ZNF2 ZNF766 ZNF213 E2F8 ZNF207 ZNF143 F11R ENSG00000232879 DUSP12 USP21 TSTD1 SLAMF7 ENSG00000228863 SLAMF1 NIT1 GC01M160999
GH01I161011 Promoter/Enhancer 2.2 FANTOM5 Ensembl ENCODE dbSUPER 10.5 +4.1 4135 11.7 CLOCK MLX ZFP64 FEZF1 DMAP1 IRF4 YY1 SLC30A9 ZNF213 E2F8 DUSP12 USP21 LOC100287049 DEDD PPOX TSTD1 LOC148430 B4GALT3 ARHGAP30 KLHDC9
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around F11R on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the F11R gene promoter:

Genomic Locations for F11R Gene

Genomic Locations for F11R Gene
chr1:160,995,211-161,021,348
(GRCh38/hg38)
Size:
26,138 bases
Orientation:
Minus strand
chr1:160,965,001-160,991,138
(GRCh37/hg19)

Genomic View for F11R Gene

Genes around F11R on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
F11R Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for F11R Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for F11R Gene

Proteins for F11R Gene

  • Protein details for F11R Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9Y624-JAM1_HUMAN
    Recommended name:
    Junctional adhesion molecule A
    Protein Accession:
    Q9Y624
    Secondary Accessions:
    • B7Z941

    Protein attributes for F11R Gene

    Size:
    299 amino acids
    Molecular mass:
    32583 Da
    Quaternary structure:
    • Interacts with the ninth PDZ domain of MPDZ (PubMed:11489913). Interacts with the first PDZ domain of PARD3 (PubMed:11489913). The association between PARD3 and PARD6B probably disrupts this interaction (By similarity). Interacts with ITGAL (via I-domain) (PubMed:15528364).
    • (Microbial infection) Interacts with Mammalian reovirus sigma-1 capsid protein.
    • (Microbial infection) Interacts with Human Rotavirus strain Wa vp4 capsid protein.

    Three dimensional structures from OCA and Proteopedia for F11R Gene

    Alternative splice isoforms for F11R Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for F11R Gene

Post-translational modifications for F11R Gene

Other Protein References for F11R Gene

Antibody Products

No data available for DME Specific Peptides for F11R Gene

Domains & Families for F11R Gene

Graphical View of Domain Structure for InterPro Entry

Q9Y624

UniProtKB/Swiss-Prot:

JAM1_HUMAN :
  • The Ig-like V-type 2 domain is necessary and sufficient for interaction with integrin alpha-L/beta-2.
  • Belongs to the immunoglobulin superfamily.
Domain:
  • The Ig-like V-type 2 domain is necessary and sufficient for interaction with integrin alpha-L/beta-2.
Family:
  • Belongs to the immunoglobulin superfamily.
genes like me logo Genes that share domains with F11R: view

Function for F11R Gene

Molecular function for F11R Gene

UniProtKB/Swiss-Prot Function:
Seems to play a role in epithelial tight junction formation. Appears early in primordial forms of cell junctions and recruits PARD3 (PubMed:11489913). The association of the PARD6-PARD3 complex may prevent the interaction of PARD3 with JAM1, thereby preventing tight junction assembly (By similarity). Plays a role in regulating monocyte transmigration involved in integrity of epithelial barrier (By similarity). Ligand for integrin alpha-L/beta-2 involved in memory T-cell and neutrophil transmigration (PubMed:11812992). Involved in platelet activation (PubMed:10753840).
UniProtKB/Swiss-Prot Function:
(Microbial infection) Acts as a receptor for Mammalian reovirus sigma-1.
UniProtKB/Swiss-Prot Function:
(Microbial infection) Acts as a receptor for Human Rotavirus strain Wa.

Phenotypes From GWAS Catalog for F11R Gene

Gene Ontology (GO) - Molecular Function for F11R Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001618 virus receptor activity IEA --
GO:0005515 protein binding IPI 16189514
GO:0030165 PDZ domain binding IPI 23885123
GO:0045296 cadherin binding IDA 25468996
genes like me logo Genes that share ontologies with F11R: view
genes like me logo Genes that share phenotypes with F11R: view

Animal Models for F11R Gene

MGI Knock Outs for F11R:

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for F11R Gene

Localization for F11R Gene

Subcellular locations from UniProtKB/Swiss-Prot for F11R Gene

Cell junction, tight junction. Cell membrane; Single-pass type I membrane protein. Note=Localized at tight junctions of both epithelial and endothelial cells. {ECO:0000269 PubMed:11171323}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for F11R gene
Compartment Confidence
plasma membrane 5
extracellular 5
cytoskeleton 3
endosome 2
peroxisome 1
nucleus 1
endoplasmic reticulum 1
cytosol 1
lysosome 1
golgi apparatus 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cell Junctions (3)
  • Microtubules (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for F11R Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS,IDA --
GO:0005911 cell-cell junction TAS 10395639
GO:0005923 bicellular tight junction IEA,IDA 23885123
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with F11R: view

Pathways & Interactions for F11R Gene

genes like me logo Genes that share pathways with F11R: view

SIGNOR curated interactions for F11R Gene

Other effect:

Gene Ontology (GO) - Biological Process for F11R Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001817 regulation of cytokine production IEA --
GO:0006954 inflammatory response TAS 10395639
GO:0007155 cell adhesion IEA --
GO:0007179 transforming growth factor beta receptor signaling pathway TAS --
GO:0009314 response to radiation IEA --
genes like me logo Genes that share ontologies with F11R: view

Drugs & Compounds for F11R Gene

(2) Drugs for F11R Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(1) Additional Compounds for F11R Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with F11R: view

Transcripts for F11R Gene

Unigene Clusters for F11R Gene

F11 receptor:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for F11R Gene

ExUns: 1a · 1b · 1c · 1d · 1e ^ 2a · 2b · 2c ^ 3 ^ 4a · 4b ^ 5a · 5b · 5c ^ 6 ^ 7 ^ 8 ^ 9 ^ 10a · 10b · 10c · 10d ^ 11a · 11b · 11c · 11d ^
SP1: - - - - - - -
SP2: - - - - - - - - - - - - - - - -
SP3: - - - - - - - - -
SP4: - - - - - -
SP5: - - - -
SP6: - - - - -
SP7: - - -
SP8: - -
SP9: - - - - - - - - - - - - - -
SP10: -
SP11:
SP12: - - -
SP13: - - - -
SP14: - - -
SP15: - -
SP16:
SP17: - - -
SP18: - -

ExUns: 12a · 12b · 12c ^ 13 ^ 14 ^ 15 ^ 16 ^ 17
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:
SP14:
SP15:
SP16:
SP17:
SP18:

Relevant External Links for F11R Gene

GeneLoc Exon Structure for
F11R
ECgene alternative splicing isoforms for
F11R

Expression for F11R Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for F11R Gene

Protein differential expression in normal tissues from HIPED for F11R Gene

This gene is overexpressed in Nasal epithelium (39.8) and Peripheral blood mononuclear cells (7.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for F11R Gene



Protein tissue co-expression partners for F11R Gene

NURSA nuclear receptor signaling pathways regulating expression of F11R Gene:

F11R

SOURCE GeneReport for Unigene cluster for F11R Gene:

Hs.517293

mRNA Expression by UniProt/SwissProt for F11R Gene:

Q9Y624-JAM1_HUMAN
Tissue specificity: Expressed in endothelium, epithelium and leukocytes (at protein level).

Evidence on tissue expression from TISSUES for F11R Gene

  • Blood(4.5)
  • Nervous system(4.5)
  • Liver(4.4)
  • Intestine(3.9)
  • Lung(3.5)
  • Heart(2.4)
  • Kidney(2.4)
  • Skin(2.1)
  • Spleen(2)
genes like me logo Genes that share expression patterns with F11R: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for F11R Gene

Orthologs for F11R Gene

This gene was present in the common ancestor of chordates.

Orthologs for F11R Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia F11R 34 33
  • 100 (n)
OneToOne
dog
(Canis familiaris)
Mammalia F11R 34 33
  • 83.7 (n)
OneToOne
cow
(Bos Taurus)
Mammalia F11R 34 33
  • 81.77 (n)
OneToOne
rat
(Rattus norvegicus)
Mammalia F11r 33
  • 79.19 (n)
mouse
(Mus musculus)
Mammalia F11r 33 16 34
  • 77.52 (n)
oppossum
(Monodelphis domestica)
Mammalia F11R 34
  • 65 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia LOC398627 33
zebrafish
(Danio rerio)
Actinopterygii f11r 33 34
  • 54.36 (n)
f11rl 34
  • 29 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 24 (a)
OneToMany
Species where no ortholog for F11R was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for F11R Gene

ENSEMBL:
Gene Tree for F11R (if available)
TreeFam:
Gene Tree for F11R (if available)

Paralogs for F11R Gene

Paralogs for F11R Gene

(2) SIMAP similar genes for F11R Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with F11R: view

Variants for F11R Gene

Sequence variations from dbSNP and Humsavar for F11R Gene

SNP ID Clin Chr 01 pos Variation AA Info Type
rs1000000886 -- 160,996,798(-) A/G 3_prime_UTR_variant
rs1000271902 -- 161,001,051(-) G/C coding_sequence_variant, synonymous_variant
rs1000311212 -- 161,009,817(-) T/C intron_variant
rs1000371594 -- 161,013,540(-) C/G intron_variant
rs1000394039 -- 161,003,527(-) T/A intron_variant

Structural Variations from Database of Genomic Variants (DGV) for F11R Gene

Variant ID Type Subtype PubMed ID
esv2667660 CNV deletion 23128226
esv3578229 CNV loss 25503493
esv3587722 CNV loss 21293372
esv3587723 CNV gain 21293372
nsv548058 CNV loss 21841781

Variation tolerance for F11R Gene

Residual Variation Intolerance Score: 29.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.77; 16.29% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for F11R Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
F11R

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for F11R Gene

Disorders for F11R Gene

MalaCards: The human disease database

(1) MalaCards diseases for F11R Gene - From: DISEASES

- elite association - COSMIC cancer census association via MalaCards
Search F11R in MalaCards View complete list of genes associated with diseases

Additional Disease Information for F11R

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with F11R: view

No data available for UniProtKB/Swiss-Prot and Genatlas for F11R Gene

Publications for F11R Gene

  1. Association of F11 receptor gene polymorphisms with central obesity and blood pressure. (PMID: 18067551) Ong KL … Cheung BM (Journal of internal medicine 2008) 3 22 44 58
  2. Characterization and chromosomal localization of JAM-1, a platelet receptor for a stimulatory monoclonal antibody. (PMID: 11171323) Naik UP … Spychala J (Journal of cell science 2001) 3 4 22 58
  3. Cloning of the human platelet F11 receptor: a cell adhesion molecule member of the immunoglobulin superfamily involved in platelet aggregation. (PMID: 10753840) Sobocka MB … Kornecki E (Blood 2000) 3 4 22 58
  4. Cutting edge: combined treatment of TNF-alpha and IFN-gamma causes redistribution of junctional adhesion molecule in human endothelial cells. (PMID: 10395639) Ozaki H … Kita T (Journal of immunology (Baltimore, Md. : 1950) 1999) 2 3 4 58
  5. Mechanisms of platelet activation by a stimulatory antibody: cross-linking of a novel platelet receptor for monoclonal antibody F11 with the Fc gamma RII receptor. (PMID: 7646439) Naik UP … Kornecki E (The Biochemical journal 1995) 2 3 4 58

Products for F11R Gene

  • Addgene plasmids for F11R

Sources for F11R Gene

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