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Aliases for F11R Gene

Aliases for F11R Gene

  • F11 Receptor 2 3
  • Junctional Adhesion Molecule 1 2 3 4
  • JAM1 3 4 6
  • Platelet Adhesion Molecule 1 3 4
  • Platelet F11 Receptor 3 4
  • PAM-1 3 4
  • JCAM 3 4
  • Junctional Adhesion Molecule A 3
  • CD321 Antigen 4
  • CD321 3
  • JAM-1 4
  • JAM-A 4
  • JAMA 3
  • KAT 3
  • JAM 3

External Ids for F11R Gene

Previous Symbols for F11R Gene

  • JAM1

Summaries for F11R Gene

Entrez Gene Summary for F11R Gene

  • Tight junctions represent one mode of cell-to-cell adhesion in epithelial or endothelial cell sheets, forming continuous seals around cells and serving as a physical barrier to prevent solutes and water from passing freely through the paracellular space. The protein encoded by this immunoglobulin superfamily gene member is an important regulator of tight junction assembly in epithelia. In addition, the encoded protein can act as (1) a receptor for reovirus, (2) a ligand for the integrin LFA1, involved in leukocyte transmigration, and (3) a platelet receptor. Multiple 5' alternatively spliced variants, encoding the same protein, have been identified but their biological validity has not been established. [provided by RefSeq, Jul 2008]

GeneCards Summary for F11R Gene

F11R (F11 Receptor) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Disease. An important paralog of this gene is JAM3.

UniProtKB/Swiss-Prot for F11R Gene

  • Seems to play a role in epithelial tight junction formation. Appears early in primordial forms of cell junctions and recruits PARD3. The association of the PARD6-PARD3 complex may prevent the interaction of PARD3 with JAM1, thereby preventing tight junction assembly (By similarity). Plays a role in regulating monocyte transmigration involved in integrity of epithelial barrier. Involved in platelet activation. In case of orthoreovirus infection, serves as receptor for the virus.

Gene Wiki entry for F11R Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for F11R Gene

Genomics for F11R Gene

Genomic Location for F11R Gene

Start:
160,995,211 bp from pter
End:
161,021,348 bp from pter
Size:
26,138 bases
Orientation:
Minus strand

Genomic View for F11R Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for F11R Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for F11R Gene

Regulatory Elements for F11R Gene

Proteins for F11R Gene

  • Protein details for F11R Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9Y624-JAM1_HUMAN
    Recommended name:
    Junctional adhesion molecule A
    Protein Accession:
    Q9Y624
    Secondary Accessions:
    • B7Z941

    Protein attributes for F11R Gene

    Size:
    299 amino acids
    Molecular mass:
    32583 Da
    Quaternary structure:
    • Interacts with the ninth PDZ domain of MPDZ. Interacts with the first PDZ domain of PARD3. The association between PARD3 and PARD6B probably disrupts this interaction. Interacts with the orthoreovirus sigma-1 capsid protein (By similarity).

    Three dimensional structures from OCA and Proteopedia for F11R Gene

    Alternative splice isoforms for F11R Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for F11R Gene

Proteomics data for F11R Gene at MOPED

Post-translational modifications for F11R Gene

Other Protein References for F11R Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for F11R Gene

Domains for F11R Gene

Gene Families for F11R Gene

HGNC:
  • CD :CD molecules
  • VSET :Immunoglobulin superfamily / V-set domain containing
  • IGD :Immunoglobulin superfamily / Immunoglobulin-like domain containing

Protein Domains for F11R Gene

UniProtKB/Swiss-Prot:

JAM1_HUMAN
Domain:
  • Contains 2 Ig-like V-type (immunoglobulin-like) domains.:
    • Q9Y624
Family:
  • Belongs to the immunoglobulin superfamily.:
    • Q9Y624
genes like me logo Genes that share domains with F11R: view

Function for F11R Gene

Molecular function for F11R Gene

UniProtKB/Swiss-Prot Function: Seems to play a role in epithelial tight junction formation. Appears early in primordial forms of cell junctions and recruits PARD3. The association of the PARD6-PARD3 complex may prevent the interaction of PARD3 with JAM1, thereby preventing tight junction assembly (By similarity). Plays a role in regulating monocyte transmigration involved in integrity of epithelial barrier. Involved in platelet activation. In case of orthoreovirus infection, serves as receptor for the virus.

Gene Ontology (GO) - Molecular Function for F11R Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 16189514
GO:0030165 PDZ domain binding IPI 23885123
genes like me logo Genes that share ontologies with F11R: view

Phenotypes for F11R Gene

genes like me logo Genes that share phenotypes with F11R: view

Animal Models for F11R Gene

MGI Knock Outs for F11R:

miRNA for F11R Gene

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for F11R Gene

Localization for F11R Gene

Subcellular locations from UniProtKB/Swiss-Prot for F11R Gene

Cell junction, tight junction. Cell membrane; Single-pass type I membrane protein. Note=Localized at tight junctions of both epithelial and endothelial cells.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for F11R Gene COMPARTMENTS Subcellular localization image for F11R gene
Compartment Confidence
plasma membrane 5
extracellular 2
cytoskeleton 1
endoplasmic reticulum 1
endosome 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for F11R Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0005911 cell-cell junction TAS 10395639
GO:0005923 bicellular tight junction IDA 23885123
GO:0015630 microtubule cytoskeleton IDA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with F11R: view

Pathways for F11R Gene

genes like me logo Genes that share pathways with F11R: view

Gene Ontology (GO) - Biological Process for F11R Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006954 inflammatory response TAS 10395639
GO:0007155 cell adhesion IEA --
GO:0007179 transforming growth factor beta receptor signaling pathway TAS --
GO:0007596 blood coagulation TAS --
GO:0009314 response to radiation IEA --
genes like me logo Genes that share ontologies with F11R: view

Compounds for F11R Gene

(3) Novoseek inferred chemical compound relationships for F11R Gene

Compound -log(P) Hits PubMed IDs
fibrinogen 16.3 1
calcium 0 3
serine 0 1
genes like me logo Genes that share compounds with F11R: view

Transcripts for F11R Gene

Unigene Clusters for F11R Gene

F11 receptor:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for F11R Gene

ExUns: 1a · 1b · 1c · 1d · 1e ^ 2a · 2b · 2c ^ 3 ^ 4a · 4b ^ 5a · 5b · 5c ^ 6 ^ 7 ^ 8 ^ 9 ^ 10a · 10b · 10c · 10d ^ 11a · 11b · 11c · 11d ^
SP1: - - - - - - -
SP2: - - - - - - - - - - - - - - - -
SP3: - - - - - - - - -
SP4: - - - - - -
SP5: - - - -
SP6: - - - - -
SP7: - - -
SP8: - -
SP9: - - - - - - - - - - - - - -
SP10: -
SP11:
SP12: - - -
SP13: - - - -
SP14: - - -
SP15: - -
SP16:
SP17: - - -
SP18: - -

ExUns: 12a · 12b · 12c ^ 13 ^ 14 ^ 15 ^ 16 ^ 17
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:
SP14:
SP15:
SP16:
SP17:
SP18:

Relevant External Links for F11R Gene

GeneLoc Exon Structure for
F11R
ECgene alternative splicing isoforms for
F11R

Expression for F11R Gene

mRNA expression in normal human tissues for F11R Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, MOPED, and MaxQB for F11R Gene

SOURCE GeneReport for Unigene cluster for F11R Gene Hs.517293

genes like me logo Genes that share expressions with F11R: view

Orthologs for F11R Gene

This gene was present in the common ancestor of chordates.

Orthologs for F11R Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia F11R 36
  • 100 (n)
  • 100 (a)
F11R 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia F11R 36
  • 81.77 (n)
  • 74.83 (a)
F11R 37
  • 74 (a)
OneToOne
dog
(Canis familiaris)
Mammalia F11R 36
  • 83.7 (n)
  • 81.52 (a)
F11R 37
  • 75 (a)
OneToOne
mouse
(Mus musculus)
Mammalia F11r 36
  • 77.52 (n)
  • 69.13 (a)
F11r 16
F11r 37
  • 67 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia F11R 37
  • 65 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia F11r 36
  • 79.19 (n)
  • 72.48 (a)
African clawed frog
(Xenopus laevis)
Amphibia LOC398627 36
zebrafish
(Danio rerio)
Actinopterygii f11r 36
  • 54.36 (n)
  • 45.77 (a)
f11r 37
  • 37 (a)
OneToMany
f11rl 37
  • 29 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 37
  • 24 (a)
OneToMany
Species with no ortholog for F11R:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for F11R Gene

ENSEMBL:
Gene Tree for F11R (if available)
TreeFam:
Gene Tree for F11R (if available)

Paralogs for F11R Gene

Paralogs for F11R Gene

Selected SIMAP similar genes for F11R Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with F11R: view

Variants for F11R Gene

Sequence variations from dbSNP and Humsavar for F11R Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs836 -- 160,998,434(+) TTCCC(A/G)CTCTA utr-variant-3-prime
rs993 -- 160,998,419(+) CGCTC(A/G/T)AGCCT utr-variant-3-prime
rs11624 -- 160,998,043(+) ACCAC(C/T)ATGCC utr-variant-3-prime
rs15687 -- 160,998,100(+) GATCN(C/T)GAACT utr-variant-3-prime
rs790055 -- 161,001,356(-) CTCCT(C/T)AGGCT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for F11R Gene

Variant ID Type Subtype PubMed ID
esv2667660 CNV Deletion 23128226

Relevant External Links for F11R Gene

HapMap Linkage Disequilibrium report
F11R

Disorders for F11R Gene

(5) Novoseek inferred disease relationships for F11R Gene

Disease -log(P) Hits PubMed IDs
thrombosis 27.9 1
atherosclerosis 11.1 1
necrosis 7.38 1
inflammation 0 2
tumors 0 1

Relevant External Links for F11R

Genetic Association Database (GAD)
F11R
Human Genome Epidemiology (HuGE) Navigator
F11R
genes like me logo Genes that share disorders with F11R: view

No data available for UniProtKB/Swiss-Prot for F11R Gene

Publications for F11R Gene

  1. Cloning of the human platelet F11 receptor: a cell adhesion molecule member of the immunoglobulin superfamily involved in platelet aggregation. (PMID: 10753840) Sobocka M.B. … Kornecki E. (Blood 2000) 3 4 23
  2. Characterization and chromosomal localization of JAM-1, a platelet receptor for a stimulatory monoclonal antibody. (PMID: 11171323) Naik U.P. … Spychala J. (J. Cell Sci. 2001) 3 4 23
  3. Association of F11 receptor gene polymorphisms with central obesity and blood pressure. (PMID: 18067551) Ong K.L. … Cheung B.M. (J. Intern. Med. 2008) 3 23 49
  4. Mechanisms of platelet activation by a stimulatory antibody: cross- linking of a novel platelet receptor for monoclonal antibody F11 with the Fc gamma RII receptor. (PMID: 7646439) Naik U.P. … Kornecki E. (Biochem. J. 1995) 2 3 4
  5. Combined treatment of TNF-alpha and IFN-gamma causes redistribution of junctional adhesion molecule in human endothelial cells. (PMID: 10395639) Ozaki H. … Kita T. (J. Immunol. 1999) 2 3 4

Products for F11R Gene

Sources for F11R Gene

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