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F11R Gene

protein-coding GIFtS: 59

GC01M159231

F11 receptor
(Previous name: junctional adhesion molecule 1 )
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
(Previous symbol: JAM1)

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
About This Section

Aliases
CD321 ^¹, ²
JAM ^²
JAM-1 ^¹, ², ³
JAM-A ^¹, ², ³
JAM1 ^², ³, ⁵
JAMA ^¹, ²
JCAM ^¹, ², ³
KAT ^²
OTTHUMP00000027880 ^²
OTTHUMP00000027881 ^²
PAM-1 ^¹, ², ³

Descriptions
CD321 antigen ^³
F11 receptor ^²
Junctional adhesion molecule 1 ^¹, ², ³
Platelet F11 receptor ^², ³
Platelet adhesion molecule 1 ^³
junctional adhesion molecule A ^²
platelet adhesion molecule ^²

External Ids
HGNC: 14685¹
Entrez Gene: 50848²
UniProtKB: Q9Y624³
Ensembl: ENSG00000158769⁷

Search outside databases for aliases for F11R gene

Previous GC identifers: GC01M156698 GC01M157743 GC01M158182 GC01M157779

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

EntrezGene summary for F11R:

Tight junctions represent one mode of cell-to-cell adhesion in epithelial or endothelial cell

sheets, forming continuous seals around cells and serving as a physical barrier to prevent solutes

and water from passing freely through the paracellular space. The protein encoded by this

immunoglobulin superfamily gene member is an important regulator of tight junction assembly in

epithelia. In addition, the encoded protein can act as (1) a receptor for reovirus, (2) a ligand

for the integrin LFA1, involved in leukocyte transmigration, and (3) a platelet receptor. Multiple

5' alternatively spliced variants, encoding the same protein, have been identified but their

biological validity has not been established. [provided by RefSeq]

UniProtKB/Swiss-Prot: JAM1_HUMAN, Q9Y624

Function: Seems to plays a role in epithelial tight junction formation. Appears early in primordial

forms of cell junctions and recruits PARD3. The association of the PARD6-PARD3 complex may prevent

the interaction of PARD3 with JAM1, thereby preventing tight junction assembly (By similarity).

Plays a role in regulating monocyte transmigration involved in integrity of epithelial barrier.

Involved in platelet activation. In case of orthoreovirus infection, serves as receptor for the

virus

Gene Wiki entry for F11R (F11_receptor)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the F11R gene

Entrez Gene cytogenetic band: 1q21.2-q21.3 Ensembl cytogenetic band: 1q23.3 HGNC cytogenetic band: 1q21.2-q21.3

F11R Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 1 GeneLoc Exon Structure

GeneLoc location for GC01M159231: (about GC identifiers)

Start:	159,232,608 bp from pter
End:	159,275,358 bp from pter
Size:	42,751 bases
Orientation:	minus strand

RefSeq DNA sequence:

NC_000001.9 NT_004487.18

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
About This Section

UniProtKB/Swiss-Prot: JAM1_HUMAN, Q9Y624 (See protein sequence)

Recommended Name: Junctional adhesion molecule A precursor

Size: 299 amino acids; 32583 Da

Subunit: Interacts with the ninth PDZ domain of MPDZ. Interacts with the first PDZ domain of PARD3.

The association between PARD3 and PARD6B probably disrupts this interaction. Interacts with the

orthoreovirus sigma-1 capsid protein (By similarity)

Subcellular location: Cell junction, tight junction. Cell membrane; Single-pass type I membrane

protein. Note=Localized at tight junctions of both epithelial and endothelial cells

PDB structure from and Proteopedia :

1NBQ (3D)

3EOY (3D)

Post-translational modifications:

N-glycosylated¹

View phosphorylation sites using PhosphoSite²

REFSEQ proteins (2 alternative transcripts):

NP_058642.1 NP_653086.1

ENSEMBL proteins:

ENSP00000357005 ENSP00000337141 ENSP00000289779

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Browse Purified and Recombinant Proteins at Millipore
	Browse Human Recombinant Proteins at Sigma-Aldrich
	R&D Systems Recombinant & Natural Proteins for F11R (JAM-A)
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Recombinant Proteins from Abcam (Junctional Adhesion Molecule 1)
	Human Recombinant Proteins from Abnova (F11R)

Browse Origene for full length recombinant human proteins expressed in human HEK293 cells

4 Gene Ontology (GO) cellular component terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005886	plasma membrane	IEA	--
GO:0005911	cell-cell junction	TAS	10395639
GO:0005923	tight junction	IEA	--
GO:0016021	integral to membrane	IEA	--

About this table

Antibodies for F11R:

	Invitrogen Antibodies for F11R
	Millipore Mono- and Polyclonal Antibodies for the study of F11R
	Sigma-Aldrich Antibodies for F11R
	R&D Systems Antibodies for F11R (JAM-A)
	Antibodies from Abcam (Junctional Adhesion Molecule 1), each with their Abpromise^SM
	Monoclonal and Polyclonal Antibodies from Abnova (F11R)
	Novus Biologicals Antibodies for F11R

Assays for F11R:

	Browse Invitrogen for biochemical assays
	Browse Kits and Assays available from Millipore
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

Graphical View of Domain Structure for InterPro Entry Q9Y624

ProtoNet protein and cluster: Q9Y624

2 Blocks protein families:

IPB003596 Immunoglobulin V-type

IPB003598 Immunoglobulin C-2 type

UniProtKB/Swiss-Prot: JAM1_HUMAN, Q9Y624

Similarity: Belongs to the immunoglobulin superfamily

Similarity: Contains 2 Ig-like V-type (immunoglobulin-like) domains

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (F11R)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (F11R)

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 5): NM_016946

Applied Biosystems Silencer® siRNAs for F11R

Sigma-Aldrich siRNA and siRNA Panels for F11R

Sigma-Aldrich shRNA Panels and shRNA for F11R

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Invitrogen Clones for F11R
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clones in CMV expression vector (see all 3): NM_016946
Myc/DDK tagged cDNA clones in CMV expression vector (see all 3): NM_016946
untagged cDNA clones in CMV expression vector (see all 5): NM_016946

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_016946

UniProtKB/Swiss-Prot: JAM1_HUMAN, Q9Y624

Function: Seems to plays a role in epithelial tight junction formation. Appears early in primordial

forms of cell junctions and recruits PARD3. The association of the PARD6-PARD3 complex may prevent

the interaction of PARD3 with JAM1, thereby preventing tight junction assembly (By similarity).

Plays a role in regulating monocyte transmigration involved in integrity of epithelial barrier.

Involved in platelet activation. In case of orthoreovirus infection, serves as receptor for the

virus

3 MGI mutant phenotypes (inferred from 4 alleles) (MGI details for F11r):

immune system

lethality-prenatal/perinatal

1 Gene Ontology (GO) molecular function term (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005515	protein binding	IEA	--

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

2 Sigma-Aldrich "Your Favorite Gene" Pathways for F11R (Your Favorite Gene powered by Ingenuity)

Tight Junction Signaling
Leukocyte Extravasation Signaling

GeneDecks F11R for the pathways selected above

About GeneDecksing

Gene Network Central^TM Interacting Genes and Proteins Network for F11R

3 Interacting proteins for F11R (Q9Y624²) via UniProtKB, MINT, and/or STRING
Interactant Interaction Details
GeneCard External ID(s)
PARD3 Q8TEW0² MINT-4085346 MINT-4085691
CASK O14936² MINT-58195
PRKCZ Q05513² MINT-4085708
About this table
4 Gene Ontology (GO) biological process terms (links to tree view):
GO ID Qualified GO term Evidence PubMed IDs
GO:0006954 inflammatory response TAS 10395639
GO:0007155 cell adhesion IEA --
GO:0030855 epithelial cell differentiation IEA --
GO:0044419 interspecies interaction between organisms IEA --
About this table

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences

Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for F11R
2 Novoseek chemical compound relationships for F11R gene

Compound	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
fibrinogen	18.24	1	12008956 (1)
calcium	0.00	3	11120739 (1), 10852816 (1), 14528017 (1)

About this table

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (F11R)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (F11R)

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 5): NM_016946

Sigma-Aldrich siRNA and siRNA Panels for F11R

Sigma-Aldrich shRNA Panels and shRNA for F11R

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_016946

REFSEQ mRNAs for F11R gene (2 alternative transcripts):

NM_016946.4 NM_144503.1

NM_016946

               OriGene GFP tagged cDNA clones in CMV expression vector (see all 3): NM_016946
                                 Myc/DDK tagged cDNA clones in CMV expression vector (see all 3): NM_016946
                                 untagged cDNA clones in CMV expression vector (see all 5): NM_016946

Additional cDNA sequence:

AF154005.1 AF172398.2 AF207907.1 AK026665.1 AK075152.1 AK299487.1 AK304412.1 AL365518.1

AY358896.1 BC001533.2 BC001699.1 BC038219.1 BT020103.1 CR533512.1 CR608619.1 CR617107.1

CR617300.1

24/46 DOTS entries (see all 46 ):

DT.121464022 DT.101964034 DT.95172353 DT.91852005 DT.100821658 DT.100827531 DT.91967531 DT.317804

DT.121464000 DT.86847063 DT.121464074 DT.91770313 DT.99946969 DT.121463976 DT.91775010 DT.97768628

DT.121463952 DT.121464027 DT.121464007 DT.121464048 DT.91770316 DT.100821659 DT.121464025 DT.91775016

24/597 AceView cDNA sequences (see all 597 ):

BF726553 AA486100 AI739011 AW149882 AA404390 AI309112 BM541282 BF196344

AI282728 CR617107 AA359412 AI590808 AW510617 BG742621 AI620558 BU674758

BQ057979 BX116635 BC001699 BM786395 AI460272 BM982030 AA741250 AW071632

highest scoring ESTs for F11R:

AA701033 AF111713 AI241578 BC001699 BC038219 BE267749 BE295468 BE513336 BE560144 BE561354

Unigene Cluster for F11R:

F11 receptor

Hs.517293 [show with all ESTs]

Unigene Representative Sequence: NM_016946

GeneLoc Exon Structure

5/18 Alternative Splicing Database (ASD) splice patterns (SP) for F11R (see all 18 )

ExUns:	1a	·	1b	·	1c	·	1d	·	1e	^	2a	·	2b	·	2c	^	3	^	4a	·	4b	^	5a	·	5b	·	5c	^	6	^	7	^	8	^	9	^	10a	·	10b	·	10c	·	10d	^	11a	·	11b	·	11c	·	11d	^
SP1:																													-		-		-				-						-						-		-
SP2:											-		-		-		-		-		-		-		-		-		-		-		-				-						-						-		-
SP3:																													-		-		-				-						-		-		-		-		-
SP4:																															-		-				-						-						-		-
SP5:																																					-						-						-		-

ExUns:	12a	·	12b	·	12c	^	13	^	14	^	15	^	16	^	17
SP1:
SP2:
SP3:
SP4:
SP5:

About this scheme

ECgene alternative splicing isoforms for F11R

3 Ensembl transcripts including schematic representations:

ENST00000368026 ENST00000335772 ENST00000289779

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

F11R expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for F11R

¹ / ² / ³

12 probe-sets matching F11R gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
56502_at²^{, 3}	U95-B	1	1.00	1.00	0.97	1.04	R02473	0.60	1.00	0.82	1
78026_at²^{, 3}	U95-E	1	1.00	1.00	0.64	0.41	AI978792	0.60	1.00	0.82	1
56500_at²^{, 3}	U95-B	1	1.00	1.00	0.97	1.26	AI241578	0.80	1.00	0.91	1
74714_at²^{, 3}	U95-D	1	1.00	1.00	0.95	1.31	AW006412	0.40	1.00	0.76	1
224097_s_at²^{, 3}	U133-B	1	1.00	1.00	--	--	AF191495	0.60	1.00	0.82	1
221664_s_at²^{, 3}	U133-A	1	1.00	1.00	--	--	AF154005	0.40	1.00	0.76	1
223000_s_at²^{, 3}	U133-B	1	1.00	1.00	--	--	AF172398	0.60	1.00	0.82	1
222354_at²^{, 3}	U133-A	1	1.00	1.00	--	--	AW675655	0.40	1.00	0.76	1
224097_s_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
221664_s_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
223000_s_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
222354_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--

GeneDecks F11R for binary patterns associated with the probe-sets selected above

About GeneDecksing

About this table

Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: --

SOURCE GeneReport for Unigene cluster: Hs.517293

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for F11R gene from 5/7 species (see all 7 )

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	F11R¹	--	F11 receptor	83.75(n) 81.59(a)	478974 XM_536132.2 XP_536132.2
chimpanzee (Pan troglodytes)	F11R¹	--	F11 receptor	100(n) 100(a)	469555 XM_001172692.1 XP_001172692.1
cow (Bos taurus)	F11R¹	--	F11 receptor	81.77(n) 74.83(a)	281258 NM_174095.4 NP_776520.1
rat (Rattus norvegicus)	F11r¹	--	F11 receptor	79.19(n) 72.48(a)	116479 NM_053796.1 NP_446248.1
mouse (Mus musculus)	F11r^{1, 5}	1 (93.30 cM)⁵	F11 receptor^{1, 5}	77.52(n)¹ 69.13(a)¹	16456¹ NM_172647.2¹ NP_766235.1¹ AA498584⁵ AA638916⁵ (see all 10)

About this table Species with no ortholog for F11R

ENSEMBL Gene Tree for F11R

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

Paralogs for F11R gene

JAM3² JAM2²

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

10/258 NCBI SNPs in F11R are shown (see all 258 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 96)

AB	SNP ID	Valid	Chr 1 pos	Sequence	Recs	AA Chg	Type	More	Recs	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--			--
	rs6695707^1,2	A,C,F,H	159258445(+)	`CAAGAA/CGAAAG`	1	--	ng3¹ trp³		12	NS EA NA EU	600
	rs1062826^1,2	A,C,F,H	159234629(-)	`GAAGCC/GAAAAG`	1	--	ut3¹ ese³		23	EA MN NA EU WA	3676
	rs1062827^1,2	C,F,H,O	159233468(-)	`GACAAG/ATAAAG`	1	--	ut3¹ ese³		8	MN NA EU EA WA	744
--	rs3737785^1,2	C,F,H	159232312(+)	`CACTCA/GATCAT`	1	--	ut3¹		4	EU EA WA	420
	rs12565932^1,2	C,F,H	159234079(+)	`AGACCT/CTTTCC`	1	--	ut3¹ trp³		4	EU EA WA	414
	rs1044478^1,2	C,F,H	159233587(-)	`GAGCCG/AGACAG`	1	--	ut3¹ ese³		5	MN EU EA WA	598
	rs836^1,2	C,F,H	159234848(+)	`TTCCCG/ACTCTA`	1	--	ut3¹ ese³		14	MN EU EA WA NA	2848
	rs10082222^1,2	H	159233246(+)	`AAGCTC/ATACTT`	1	--	ut3¹		4	EU EA WA	416
--	rs11624^1,2	F	159234457(+)	`ACCACC/TATGCC`	1	--	ut3¹		2	MN	372
	rs12759428^1,2	H	159233427(+)	`CCTCCA/CCAGAA`	1	--	ut3¹ ese³		4	EU EA WA	416

About this table

HapMap Linkage Disequilibrium images for F11R (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

OMIM: 605721

5 Novoseek disease relationships for F11R gene

Disease	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
thrombosis	30.04	1	17481380 (1)
atherosclerosis	13.69	1	17964041 (1)
necrosis	3.29	1	15886398 (1)
inflammation	0.00	2	17481380 (1), 17615384 (1)
tumors	0.00	1	15886398 (1)

About this table

Human Genome Epidemiology Navigator: F11R (4 documents)

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
About This Section

10/101 PubMed articles for F11R gene (see all 101 ):

Combined treatment of TNF-alpha and IFN-gamma causes redistribution of junctional adhesion molecule in human endothelial cells. (PubMed id 10395639)^{2, 3, 4} Ozaki H.... Kita T. (1999)
Mechanisms of platelet activation by a stimulatory antibody: cross-linking of a novel platelet receptor for monoclonal antibody F11 with the Fc gamma RII receptor. (PubMed id 7646439)^{2, 3, 4} Naik U.P....Kornecki E. (1995)
Characterization and chromosomal localization of JAM-1, a platelet receptor for a stimulatory monoclonal antibody. (PubMed id 11171323)^{1, 3, 4} Naik U.P.... Spychala J. (2001)
Cloning of the human platelet F11 receptor: a cell adhesion molecule member of the immunoglobulin superfamily involved in platelet aggregation. (PubMed id 10753840)^{1, 3, 4} Sobocka M.B.... Kornecki E. (2000)
Signal peptide prediction based on analysis of experimentally verified cleavage sites. (PubMed id 15340161)^{3, 4} Zhang Z. and Henzel W.J. (2004)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{3, 4} Gerhard D.S....Malek J. (2004)
Crystal structure of human junctional adhesion molecule 1: implications for reovirus binding. (PubMed id 12697893)^{3, 4} Prota A.E.... Stehle T. (2003)
Leukocyte-endothelial-cell interactions in leukocyte transmigration and the inflammatory response. (PubMed id 12810109)^{3, 4} Muller W.A. (2003)
Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides. (PubMed id 12665801)^{3, 4} Gevaert K.... Vandekerckhove J. (2003)
The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PubMed id 12975309)^{3, 4} Clark H.F....Gray A. (2003)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
About This Section

Entrez Gene: 50848	HGNC: 14685	AceView: F11R	Ensembl:ENSG00000158769	euGenes: HUgn50848
ECgene: F11R	H-InvDB: F11R

(According to HUGE)
About This Section

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Licensable Technologies for F11R
(Available from WIS Yeda, Salk, Tufts)

About This Section

(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section

Products for F11R:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for F11R-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for F11R		Antibodies for F11R
	Explore super-pooled esiRNAs		Browse proteins at Sigma-Aldrich
	Lentivirus-delivered shRNAs for F11R		Browse small molecules at Sigma-Aldrich
	"Your Favorite Gene" Pathways		feedback

	Antibodies		Primer Pairs
	Cell Culture Products		ELISAs
	Flow Cytometry Kits		Protease Activity Assays & Reagents
	Cell Selection/Detection Kits & Reagents		ELISA/Assay Development Kits & Reagents
	Multiplex/Array Assay Kits & Reagents		ELISpot Kits & Development Modules
	Recombinant & Natural Proteins

	Recombinant Proteins (F11R)
	Antibodies (F11R)
	Chimera RNAi (F11R)
	Custom Service for Mouse Mab
	Custom Service for Rabbit Pab from Full-length Protein

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	Recombinant Proteins (Junctional Adhesion Molecule 1)
	Antibodies (Junctional Adhesion Molecule 1)

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Antibodies for F11R

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F11R Gene at Home site.
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F11R Gene

protein-coding GIFtS: 59

Aliases &
Descriptions
for F11R

Summaries
for F11R

Genomic Location
for F11R

Proteins
for F11R

Protein Domains/
Families
for F11R

Gene Function
for F11R

Pathways & Interactions
for F11R

Drugs & Compounds
for F11R

Transcripts
for F11R

Expression
for F11R

Orthologs
for F11R

Paralogs
for F11R

SNPs/Variants
for F11R

Disorders & Mutations
for F11R

Medical News
for F11R

Publications
for F11R

Search for F11R

Genome Databases showing F11R

Other Databases showing F11R

Specialized Databases showing F11R

Licensable Technologies
for F11R

Services
for F11R

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

F11R Gene

protein-coding GIFtS: 59

Aliases & Descriptionsfor F11R

Summariesfor F11R

Genomic Locationfor F11R

Proteinsfor F11R

Protein Domains/Familiesfor F11R

Gene Functionfor F11R

Pathways & Interactionsfor F11R

Drugs & Compoundsfor F11R

Transcriptsfor F11R

Expression for F11R

Orthologsfor F11R

Paralogsfor F11R

SNPs/Variantsfor F11R

Disorders & Mutationsfor F11R

Medical Newsfor F11R

Publicationsfor F11R

Search for F11R

Genome Databases showing F11R

Other Databases showing F11R

Specialized Databases showing F11R

Licensable Technologiesfor F11R

Servicesfor F11R

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for F11R

Summaries
for F11R

Genomic Location
for F11R

Proteins
for F11R

Protein Domains/
Families
for F11R

Gene Function
for F11R

Pathways & Interactions
for F11R

Drugs & Compounds
for F11R

Transcripts
for F11R

Expression
for F11R

Orthologs
for F11R

Paralogs
for F11R

SNPs/Variants
for F11R

Disorders & Mutations
for F11R

Medical News
for F11R

Publications
for F11R

Licensable Technologies
for F11R

Services
for F11R