V3 here soon-try beta now


Gene Search (GeneCards Home)	\|	GeneCards Guide	\|	User Feedback	\|	Terms of Use	\|	Notice about third-party sites

F11 Gene

protein-coding GIFtS: 69

GC04P187424

coagulation factor XI
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
About This Section

Aliases
EC 3.4.21.27 ^³
FXI ^¹, ², ³
MGC141891 ^²
PTA ^³

Descriptions
Plasma thromboplastin antecedent ^², ³
coagulation factor XI ^²

External Ids
HGNC: 3529¹
Entrez Gene: 2160²
UniProtKB: P03951³
Ensembl: ENSG00000088926⁷

Search outside databases for aliases for F11 gene

Previous GC identifers: GC04P188221 GC04P187867 GC04P187771 GC04P187883 GC04P187562

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

EntrezGene summary for F11:

This gene encodes coagulation factor XI of the blood coagulation cascade. This protein is present

in plasma as a zymogen, which is a unique plasma coagulation enzyme because it exists as a

homodimer consisting of two identical polypeptide chains linked by disulfide bonds. During

activation of the plasma factor XI, an internal peptide bond is cleaved by factor XIIa (or XII) in

each of the two chains, resulting in activated factor XIa, a serine protease composed of two heavy

and two light chains held together by disulfide bonds. This activated plasma factor XI triggers

the middle phase of the intrisic pathway of blood coagulation by activating factor IX. Defects in

this factor lead to Rosenthal syndrome, a blood coagulation abnormality. [provided by RefSeq]

UniProtKB/Swiss-Prot: FA11_HUMAN, P03951

Function: Factor XI triggers the middle phase of the intrinsic pathway of blood coagulation by

activating factor IX

Gene Wiki entry for F11 (Factor_XI)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the F11 gene

Entrez Gene cytogenetic band: 4q35 Ensembl cytogenetic band: 4q35.2 HGNC cytogenetic band: 4q35

F11 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 4 GeneLoc Exon Structure

GeneLoc location for GC04P187424: (about GC identifiers)

Start:	187,424,112 bp from pter
End:	187,447,829 bp from pter
Size:	23,718 bases
Orientation:	plus strand

RefSeq DNA sequence:

NC_000004.10 NT_022792.17

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
About This Section

UniProtKB/Swiss-Prot: FA11_HUMAN, P03951 (See protein sequence)

Recommended Name: Coagulation factor XI precursor

Size: 625 amino acids; 70109 Da

Subunit: Homodimer; disulfide-linked. After activation the heavy and light chains are also linked

by a disulfide bond

Subcellular location: Secreted

PDB structures from and Proteopedia :

1XX9 (3D)

1XXD (3D)

1XXF (3D)

1ZHM (3D)

1ZHP (3D)

1ZHR (3D)

1ZJD (3D)

1ZLR (3D)

1ZMJ (3D)

1ZML (3D)

1ZMN (3D)

1ZOM (3D)

1ZPB (3D)

1ZPC (3D)

1ZPZ (3D)

1ZRK (3D)

1ZSJ (3D)

1ZSK (3D)

1ZSL (3D)

1ZTJ (3D)

1ZTK (3D)

1ZTL (3D)

2F83 (3D)

2FDA (3D)

2J8J (3D)

2J8L (3D)

3BG8 (3D)

Secondary accessions: Q4W5C2 Q9Y495

Alternative splicing: 2 isoforms: P03951-1 P03951-2

Post-translational modifications:

Activated by factor XIIa (or XII), which cleaves each polypeptide after Arg-387 into the light

chain, which contains the active site, and the heavy chain, which associates with high molecular

weight (HMW) kininogen¹

View phosphorylation sites using PhosphoSite²

REFSEQ proteins: NP_000119.1

ENSEMBL proteins:

ENSP00000384957 ENSP00000264692 ENSP00000264691

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Browse Purified and Recombinant Proteins at Millipore
	Browse Human Recombinant Proteins at Sigma-Aldrich
	R&D Systems Recombinant & Natural Proteins for F11 (Coagulation Factor XI)
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Recombinant Proteins from Abcam (Factor XI, Factor XIa)
	Human Recombinant Proteins from Abnova (F11)

Browse Origene for full length recombinant human proteins expressed in human HEK293 cells

3 Gene Ontology (GO) cellular component terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005576	extracellular region	NAS	9593722
GO:0005615	extracellular space	IDA	89876
GO:0016020	membrane	NAS	9593722

About this table

Antibodies for F11:

	Browse Antibodies Central at Invitrogen
	Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	Sigma-Aldrich Antibodies for F11
	R&D Systems Antibodies for F11 (Coagulation Factor XI)
	Antibodies from Abcam (Factor XI, Factor XIa), each with their Abpromise^SM
	Monoclonal and Polyclonal Antibodies from Abnova (F11)
	Novus Biologicals Antibodies for F11

Assays for F11:

	Browse Invitrogen for biochemical assays
	Browse Kits and Assays available from Millipore
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

Graphical View of Domain Structure for InterPro Entry P03951

ProtoNet protein and cluster: P03951

4 Blocks protein families:

IPB000177 Apple domain

IPB001254 Serine protease

IPB001314 Chymotrypsin serine protease family (S1) signature

IPB003014 N/apple PAN

UniProtKB/Swiss-Prot: FA11_HUMAN, P03951

Similarity: Belongs to the peptidase S1 family. Plasma kallikrein subfamily

Similarity: Contains 4 apple domains

Similarity: Contains 1 peptidase S1 domain

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (F11)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (F11)

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2): NM_000128

Applied Biosystems Silencer® siRNAs for F11

Sigma-Aldrich siRNA and siRNA Panels for F11

Sigma-Aldrich shRNA for F11

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Browse Clone Ranger at Invitrogen for clones
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clone in CMV expression vector: NM_000128
Myc/DDK tagged cDNA clone in CMV expression vector: NM_000128
untagged cDNA clones in CMV expression vector (see all 2): NM_000128

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_000128

UniProtKB/Swiss-Prot: FA11_HUMAN, P03951

Function: Factor XI triggers the middle phase of the intrinsic pathway of blood coagulation by

activating factor IX

Catalytic activity: Selective cleavage of Arg- -Ala and Arg- -Val bonds in factor IX to form factor

IXa

Enzyme Number (IUBMB): EC 3.4.21.27

Genatlas biochemistry entry for F11:

coagulation factor XI,80kDa,homodimer of two monomers (plasma thromboplastin antecedent),contact

activation pathway

12 MGI mutant phenotypes (inferred from 1 allele) (MGI details for F11):

	behavior/neurological	growth/size	hematopoietic system	homeostasis/metabolism
immune system	lethality-prenatal/perinatal	life span-post-weaning/aging	liver/biliary system	muscle
nervous system	respiratory system

3 Gene Ontology (GO) molecular function terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0004252	serine-type endopeptidase activity	NAS	9593722
GO:0008201	heparin binding	IEA	--
GO:0008233	peptidase activity	IEA	--

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

1 Sigma-Aldrich "Your Favorite Gene" Pathway for F11 (Your Favorite Gene powered by Ingenuity)

Coagulation System

GeneDecks F11 for the pathways selected above

About GeneDecksing

Gene Network Central^TM Interacting Genes and Proteins Network for F11

5/28 Interacting proteins for F11 (ENSP00000264691³) via UniProtKB, MINT, and/or STRING (see all 28 )

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
KNG1	ENSP00000265023³	STRING (score=.989)
APP	ENSP00000284981³	STRING (score=.986)
F8	ENSP00000327895³	STRING (score=.981)
GP1BA	ENSP00000329380³	STRING (score=.981)
C1QBP	ENSP00000225698³	STRING (score=.96)

About this table

4 Gene Ontology (GO) biological process terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006508	proteolysis	IEA	--
GO:0030193	regulation of blood coagulation	IEA	--
GO:0031639	plasminogen activation	IDA	89876
GO:0051919	positive regulation of fibrinolysis	IDA	89876

About this table

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences

Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for F11
6 Novoseek chemical compound relationships for F11 gene

Compound	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
fibrinogen	68.26	35	19290079 (3), 12473138 (2), 11111234 (2), 18409149 (2) (see all 25)
endotoxin	7.40	4	7685203 (2), 9787166 (2)
heparan sulfate	5.67	4	8603018 (3), 11307829 (1)
phospholipid	0.00	2	11342438 (1), 10548073 (1)
homocysteine	0.00	1	15077875 (1)
zinc	0.00	3	12944405 (2)

About this table

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (F11)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (F11)

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2): NM_000128

Sigma-Aldrich siRNA and siRNA Panels for F11

Sigma-Aldrich shRNA for F11

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_000128

REFSEQ mRNAs for F11 gene:

NM_000128.3

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_000128

              OriGene GFP tagged cDNA clone in CMV expression vector: NM_000128
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_000128
                                 untagged cDNA clones in CMV expression vector (see all 2): NM_000128

Additional cDNA sequence: BC034307.1

7 DOTS entries:

DT.109659 DT.92420277 DT.95148689 DT.92420278 DT.92420280 DT.91789182 DT.91820500

23 AceView cDNA sequences:

AL703888 BC074947 BC074946 NM_005958 BI520221 U14108 CB155561 AI138290

BX112166 CB122088 AF435588 AI204202 AI126472 BC038717 BC034307 AI001834

BU567547 AI221202 BI520849 BI459826 AI208101 BU194998 BG719069

highest scoring ESTs for F11:

M13142 AF045649 AI675074 AW242380 BE326842 BF511049 BQ271011 CA774579 CA848332 H69115

Unigene Clusters for F11:

Coagulation factor XI

Hs.1430 [show with all ESTs], Hs.714107 [show with all ESTs]

Unigene Representative Sequences: NM_000128, BC034307

GeneLoc Exon Structure

5/6 Alternative Splicing Database (ASD) splice patterns (SP) for F11 (see all 6 )

ExUns:	1a	·	1b	·	1c	^	2	^	3	^	4	^	5a	·	5b	^	6	^	7	^	8	^	9a	·	9b	^	10a	·	10b	^	11a	·	11b	^	12	^	13a	·	13b	^	14	^	15a	·	15b	^	16a	·	16b
SP1:															-																-		-
SP2:													-		-																-		-
SP3:																															-		-								-
SP4:
SP5:																															-

About this scheme

ECgene alternative splicing isoforms for F11

3 Ensembl transcripts including schematic representations:

ENST00000403665 ENST00000264692 ENST00000264691

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

F11 expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for F11

¹ / ² / ³

6 probe-sets matching F11 gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
35591_at²^{, 3}	U95-A	1	1.00	1.00	1.00	1.00	M13142	1.00	1.00	1.00	1
206610_s_at²^{, 3}	U133-A	1	1.00	1.00	--	--	NM_000128	0.60	1.00	0.82	1
206610_s_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
1569592_a_at*²	U133Plus2	NULL	0.00	0.00	--	--	--	--	--	--	--
1569591_at*²	U133Plus2	NULL	0.00	0.00	--	--	--	--	--	--	--
1563160_at*²	U133Plus2	NULL	0.00	0.00	--	--	--	--	--	--	--

GeneDecks F11 for binary patterns associated with the probe-sets selected above

About GeneDecksing

About this table

Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: TGCCAGGATG

SOURCE GeneReport for Unigene clusters: Hs.1430 Hs.714107
Expression variation in blood from EXPOLDB for F11
UniProtKB/Swiss-Prot: FA11_HUMAN, P03951
Tissue specificity: Isoform 2 is produced by platelets and megakaryocytes but absent from other
blood cells

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for F11 gene from 5/7 species (see all 7 )

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
chimpanzee (Pan troglodytes)	F11¹	--	coagulation factor XI	99.36(n) 99.52(a)	461643 XM_001165847.1 XP_001165847.1
cow (Bos taurus)	F11¹	--	coagulation factor XI	83.95(n) 80.9(a)	407998 NM_001008665.1 NP_001008665.1
rat (Rattus norvegicus)	F11¹	--	coagulation factor XI	80.57(n) 77.29(a)	290757 XM_224872.4 XP_224872.4
mouse (Mus musculus)	F11^{1, 5}	8 (25.00 cM)⁵	coagulation factor XI^{1, 5}	81.35(n)¹ 78.3(a)¹	109821¹ NM_028066.1¹ NP_082342.1¹ AF356627⁵ AI503996⁵ (see all 7)
chicken (Gallus gallus)	F11¹	--	coagulation factor XI	65.65(n) 60.23(a)	422723 XM_420678.2 XP_420678.2

About this table Species with no ortholog for F11

ENSEMBL Gene Tree for F11

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

Paralogs for F11 gene

ENSG00000175509² KLKB1² ACR² TMPRSS5² HPN²

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

10/230 NCBI SNPs in F11 are shown (see all 230 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 128)

AB	SNP ID	Valid	Chr 4 pos	Sequence	Recs	AA Chg	Type	More	Recs	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--			--
	rs3733403^1,2	A,C,F,H	187424129(+)	`AAAATC/GAAGTT`	1	--	ut5¹		15	NS NA EU EA WA	1304
	rs3756009^1,2	A,C,F,H	187423105(+)	`CCTTCA/GTGGAA`	1	--	ng5¹		13	NS NA EU EA WA	1020
	rs4253430^1,2	A,C,F,H	187447058(+)	`ATATAC/GCAGAA`	1	--	ut3¹		24	NS EA NA EU WA	2216
	rs4253429^1,2	C,F,H	187447027(+)	`GCAATA/GTTTCT`	1	--	ut3¹		10	NS EA NA EU WA	694
	rs1062547^1,2	A,C,F	187447241(+)	`AAGAAA/TTTGAT`	1	--	ut3¹		6	NS MN NA	418
	rs5967^1,2	C,F,H	187438521(+)	`ATCCTG/TCAACG`	1	C/F	mis¹ ese³		21	NS MN NA EU EA WA	1978
	rs3756008^1,2	C,F,H	187422379(+)	`ACAATA/TCAAGG`	1	--	ng5¹		17	EA NS EU NA WA	2922
	rs3822056^1,2	C,F,H	187423999(+)	`TCAATG/TAATCC`	1	--	ng5¹		14	NS EU EA WA NA	1126
	rs5969^1,2	C,F,H	187434514(+)	`TTCCCA/GGGAAT`	1	Q/R	mis¹ ese³		10	MN EU EA WA	1126
	rs4253431^1,2	C,F,H	187447614(+)	`AGACTG/ACATCC`	1	--	ut3¹		15	NS NA EU EA WA	1250

About this table

HapMap Linkage Disequilibrium images for F11 (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

OMIM: 264900 disorders: 612416 612416

UniProtKB/Swiss-Prot: FA11_HUMAN, P03951

Defects in F11 are the cause of F11 deficiency [MIM:612416]; also called plasma

thromboplastin antecedent deficiency or Rosenthal syndrome. It is a blood coagulation abnormality

occurring in high frequency in Ashkenazi jews. F11-deficient patients are prone to excessive

bleeding after haemostatic challenge

10/21 Novoseek disease relationships for F11 gene (see all 21 )

Disease	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
factor xi deficiency	97.57	23	15182578 (3), 8445157 (2), 17607578 (1), 18832909 (1) (see all 18)
bleeding tendency	82.08	17	14872426 (2), 7631304 (2), 14717969 (1), 17607578 (1) (see all 11)
inherited coagulation disorders	81.50	3	19448217 (1), 16670069 (1), 18839438 (1)
coagulopathy	78.07	30	9482440 (2), 11127865 (1), 16086308 (1), 17581330 (1) (see all 20)
afibrinogenemia	70.19	3	19174980 (1), 16670069 (1), 16684009 (1)
hemophilia a	67.87	7	16424651 (1), 19236780 (1), 10513769 (1), 14717973 (1)
coagulation factor deficiency	67.76	1	16078927 (1)
von willebrand disease	65.06	17	9482440 (3), 10215946 (1), 15357775 (1), 8266918 (1) (see all 7)
thrombophilia	61.36	2	15692250 (1), 14521595 (1)
bleeding	61.27	70	18384352 (3), 14872426 (2), 8757530 (2), 10027710 (2) (see all 37)

About this table

Genatlas disease: F11

bleeding diathesis,mild,inconstant

Human Gene Mutation Database: F11
Genetic Association Database: F11
Human Genome Epidemiology Navigator: F11 (7 documents)

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
About This Section

10/258 PubMed articles for F11 gene (see all 258 ):

Factor XI deficiency in French Basques is caused predominantly by an ancestral Cys38Arg mutation in the factor XI gene. (PubMed id 11895778)^{3, 4, 6} Zivelin A....Seligsohn U. (2002)
Heterozygous factor XI deficiency associated with three novel mutations. (PubMed id 10606881)^{3, 4, 6} Mitchell M.... Alhaq A. (1999)
Expression of human blood coagulation factor XI: characterization of the defect in factor XI type III deficiency. (PubMed id 1547342)^{1, 3, 4} Meijers J.C.... Chung D.W. (1992)
Identification of a novel mutation in a non-Jewish factor XI deficient kindred. (PubMed id 10027710)^{1, 3, 4} Alhaq A.... Savidge G. (1999)
Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry. (PubMed id 16335952)^{3, 4} Liu T.... Smith R.D. (2005)
Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PubMed id 15815621)^{3, 4} Hillier L.W....Wilson R.K. (2005)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{3, 4} Gerhard D.S....Malek J. (2004)
Localization of a heparin binding site in the catalytic domain of factor XIa. (PubMed id 11412111)^{3, 4} Badellino K.O. and Walsh P.N. (2001)
Characterization of single-nucleotide polymorphisms in coding regions of human genes. (PubMed id 10391209)^{3, 4} Cargill M....Lander E.S. (1999)
Molecular cloning of platelet factor XI, an alternative splicing product of the plasma factor XI gene. (PubMed id 9593722)^{3, 4} Hsu T.-C.... Walsh P.N. (1998)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
About This Section

Entrez Gene: 2160	HGNC: 3529	AceView: MTNR1A	Ensembl:ENSG00000088926	euGenes: HUgn2160
ECgene: F11	H-InvDB: F11

(According to HUGE)
About This Section

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
ATLAS Chromosomes in Cancer entry for F11	Genetics and Cytogenetics in Oncology and Haematology
Wikipedia	http://en.wikipedia.org/wiki/Factor_XI
GeneReviews	http://www.genetests.org/query?gene=F11
SeattleSNPs	http://pga.gs.washington.edu/data/f11/

Licensable Technologies for F11
(Available from WIS Yeda, Salk, Tufts)

About This Section

(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section

Products for F11:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for F11-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for F11		Antibodies for F11
	Explore super-pooled esiRNAs		Browse proteins at Sigma-Aldrich
	Lentivirus-delivered shRNAs for F11		Browse small molecules at Sigma-Aldrich
	"Your Favorite Gene" Pathways		feedback

	Antibodies		Primer Pairs
	Cell Culture Products		ELISAs
	Flow Cytometry Kits		Protease Activity Assays & Reagents
	Cell Selection/Detection Kits & Reagents		ELISA/Assay Development Kits & Reagents
	Multiplex/Array Assay Kits & Reagents		ELISpot Kits & Development Modules
	Recombinant & Natural Proteins

	Recombinant Proteins (F11)
	Antibodies (F11)
	Chimera RNAi (F11)
	Custom Service for Mouse Mab
	Custom Service for Rabbit Pab from Full-length Protein

Search for Antibodies & Assays

	Recombinant Proteins (Factor XI, Factor XIa)
	Antibodies (Factor XI, Factor XIa)

Search OriGene for F11

Search Tocris compounds for F11

Search www.enzolifesicences.com for proteins, assays, substrates, inhibitors & antibodies

Antibodies for F11

GeneCards Homepage - Last full update: 2 Jul 2009 Incremental update: 13 Oct 2009

Random Gene From GIFtS :

about GIFtS

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Developed at the Crown Human Genome Center & Weizmann Institute of Science

The GeneCards Human Gene Database: Copyright © 1996-2009, Weizmann Institute of Science. All Rights Reserved.
F11 Gene at Home site.
Version 2.41.1
server5.xennexinc.com

F11 Gene

protein-coding GIFtS: 69

Aliases &
Descriptions
for F11

Summaries
for F11

Genomic Location
for F11

Proteins
for F11

Protein Domains/
Families
for F11

Gene Function
for F11

Pathways & Interactions
for F11

Drugs & Compounds
for F11

Transcripts
for F11

Expression
for F11

Orthologs
for F11

Paralogs
for F11

SNPs/Variants
for F11

Disorders & Mutations
for F11

Medical News
for F11

Publications
for F11

Search for F11

Genome Databases showing F11

Other Databases showing F11

Specialized Databases showing F11

Licensable Technologies
for F11

Services
for F11

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

F11 Gene

protein-coding GIFtS: 69

Aliases & Descriptionsfor F11

Summariesfor F11

Genomic Locationfor F11

Proteinsfor F11

Protein Domains/Familiesfor F11

Gene Functionfor F11

Pathways & Interactionsfor F11

Drugs & Compoundsfor F11

Transcriptsfor F11

Expression for F11

Orthologsfor F11

Paralogsfor F11

SNPs/Variantsfor F11

Disorders & Mutationsfor F11

Medical Newsfor F11

Publicationsfor F11

Search for F11

Genome Databases showing F11

Other Databases showing F11

Specialized Databases showing F11

Licensable Technologiesfor F11

Servicesfor F11

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for F11

Summaries
for F11

Genomic Location
for F11

Proteins
for F11

Protein Domains/
Families
for F11

Gene Function
for F11

Pathways & Interactions
for F11

Drugs & Compounds
for F11

Transcripts
for F11

Expression
for F11

Orthologs
for F11

Paralogs
for F11

SNPs/Variants
for F11

Disorders & Mutations
for F11

Medical News
for F11

Publications
for F11

Licensable Technologies
for F11

Services
for F11