Aliases for F11 Gene
External Ids for F11 Gene
Previous GeneCards Identifiers for F11 Gene
This gene encodes coagulation factor XI of the blood coagulation cascade. This protein is present in plasma as a zymogen, which is a unique plasma coagulation enzyme because it exists as a homodimer consisting of two identical polypeptide chains linked by disulfide bonds. During activation of the plasma factor XI, an internal peptide bond is cleaved by factor XIIa (or XII) in each of the two chains, resulting in activated factor XIa, a serine protease composed of two heavy and two light chains held together by disulfide bonds. This activated plasma factor XI triggers the middle phase of the intrisic pathway of blood coagulation by activating factor IX. Defects in this factor lead to Rosenthal syndrome, a blood coagulation abnormality. [provided by RefSeq, Jul 2008]
GeneCards Summary for F11 Gene
F11 (Coagulation Factor XI) is a Protein Coding gene. Diseases associated with F11 include Factor Xi Deficiency, Autosomal Recessive and Acquired Thrombocytopenia. Among its related pathways are Platelet activation, signaling and aggregation and Formation of Fibrin Clot (Clotting Cascade). GO annotations related to this gene include serine-type endopeptidase activity and serine-type aminopeptidase activity. An important paralog of this gene is KLKB1.
UniProtKB/Swiss-Prot for F11 Gene
Factor XI triggers the middle phase of the intrinsic pathway of blood coagulation by activating factor IX.