Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 



F10 Gene

protein-coding   GIFtS: 72
GCID: GC13P113777

Coagulation Factor X

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

TryGeneCards Plus

Aliases
Coagulation Factor X1 2     Factor Xa2
Stuart-Prower Factor2 3     prothrombinase2
EC 3.4.21.63 8     Stuart Factor3
FX2     EC 3.4.218
FXA2     

External Ids:    HGNC: 35281   Entrez Gene: 21592   Ensembl: ENSG000001262187   OMIM: 6138725   UniProtKB: P007423   

Export aliases for F10 gene to outside databases

Previous GC identifers: GC13P112387 GC13P108414 GC13P112863 GC13P111725 GC13P112825 GC13P094215


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

TryGeneCards Plus

Entrez Gene summary for F10 Gene:
This gene encodes the vitamin K-dependent coagulation factor X of the blood coagulation cascade. This factor
undergoes multiple processing steps before its preproprotein is converted to a mature two-chain form by the
excision of the tripeptide RKR. Two chains of the factor are held together by 1 or more disulfide bonds; the
light chain contains 2 EGF-like domains, while the heavy chain contains the catalytic domain which is
structurally homologous to those of the other hemostatic serine proteases. The mature factor is activated by the
cleavage of the activation peptide by factor IXa (in the intrisic pathway), or by factor VIIa (in the extrinsic
pathway). The activated factor then converts prothrombin to thrombin in the presence of factor Va, Ca+2, and
phospholipid during blood clotting. Mutations of this gene result in factor X deficiency, a hemorrhagic condition
of variable severity. (provided by RefSeq, Jul 2008)

GeneCards Summary for F10 Gene:
F10 (coagulation factor X) is a protein-coding gene. Diseases associated with F10 include factor x deficiency, and antithrombin iii deficiency. GO annotations related to this gene include serine-type endopeptidase activity and calcium ion binding. An important paralog of this gene is PROZ.

UniProtKB/Swiss-Prot: FA10_HUMAN, P00742
Function: Factor Xa is a vitamin K-dependent glycoprotein that converts prothrombin to thrombin in the presence of
factor Va, calcium and phospholipid during blood clotting

Gene Wiki entry for F10 (Factor X) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

TryGeneCards Plus
RefSeq DNA sequence:
NC_000013.11  NT_027140.7  NC_018924.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the F10 gene promoter:
         E2F-4   c-Fos   E2F-1   E2F   AP-1   ATF-2   c-Jun   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidF10 promoter sequence
   Search Chromatin IP Primers for F10

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat F10


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 13q34   Ensembl cytogenetic band:  13q34   HGNC cytogenetic band: 13q34

F10 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
F10 gene location

GeneLoc information about chromosome 13         GeneLoc Exon Structure

GeneLoc location for GC13P113777:  view genomic region     (about GC identifiers)

Start:
113,777,113 bp from pter      End:
113,803,843 bp from pter
Size:
26,731 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
About This Section

TryGeneCards Plus

UniProtKB/Swiss-Prot: FA10_HUMAN, P00742 (See protein sequence)
Recommended Name: Coagulation factor X precursor  
Size: 488 amino acids; 54732 Da
Subunit: The two chains are formed from a single-chain precursor by the excision of two Arg residues and are held
together by 1 or more disulfide bonds. Forms a heterodimer with SERPINA5
Selected PDB 3D structures from and Proteopedia for F10 (see all 128):
1C5M (3D)        1EZQ (3D)        1F0R (3D)        1F0S (3D)        1FAX (3D)        1FJS (3D)    
Secondary accessions: Q14340

Explore the universe of human proteins at neXtProt for F10: NX_P00742

Explore proteomics data for F10 at MOPED

Post-translational modifications: 

  • The vitamin K-dependent, enzymatic carboxylation of some glutamate residues allows the modified protein to bind
    calcium1
  • N- and O-glycosylated. O-glycosylated with core 1 or possibly core 8 glycans1
  • The activation peptide is cleaved by factor IXa (in the intrinsic pathway), or by factor VIIa (in the extrinsic
    pathway)1
  • The iron and 2-oxoglutarate dependent 3-hydroxylation of aspartate and asparagine is (R) stereospecific within EGF
    domains1
  • Glycosylation2 at Thr199, Thr211, Asn221, Asn231, Thr483
  • Modification sites at PhosphoSitePlus
  • Selected DME Specific Peptides for F10 (P00742) (see all 13)
     FCGGTIL  GECPWQA  SWGEGCA  TGIVSWG 


    See F10 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_000495.1  
    ENSEMBL proteins: 
     ENSP00000387092   ENSP00000364701   ENSP00000364709   ENSP00000386320  
    Reactome Protein details: P00742

    F10 Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    R&D Systems Recombinant & Natural Proteins for F10 (Coagulation Factor X)
    Enzo Life Sciences proteins for F10
    OriGene Purified Protein for F10
    OriGene Protein Over-expression Lysate for F10
    OriGene MassSpec for F10
    OriGene Custom Protein Services for F10
    GenScript Custom Purified and Recombinant Proteins Services for F10
    Novus Biologicals F10 Protein
    Novus Biologicals F10 Lysate
    Sino Biological Recombinant Protein for F10
    Sino Biological Cell Lysate for F10
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for F10

    F10 Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    R&D Systems Antibodies for F10 (Coagulation Factor X)
    OriGene Antibodies for F10
    OriGene Custom Antibody Services for F10
    Novus Biologicals F10 Antibodies
    Abcam antibodies for F10
    Cloud-Clone Corp. Antibodies for F10
    ThermoFisher Antibody for F10
    LSBio Antibodies in human, mouse, rat for F10

    F10 Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for F10
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for F10
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for F10
    Cloud-Clone Corp. CLIAs for F10


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    TryGeneCards Plus
    Selected InterPro protein domains (see all 12):
     IPR017857 Coagulation_fac_subgr_Gla_dom
     IPR001314 Peptidase_S1A
     IPR000742 EG-like_dom
     IPR000152 EGF-type_Asp/Asn_hydroxyl_site
     IPR018097 EGF_Ca-bd_CS

    Graphical View of Domain Structure for InterPro Entry P00742

    ProtoNet protein and cluster: P00742

    Selected Blocks protein domains (see all 7):
    IPB000152 Aspartic acid and asparagine hydroxylation site
    IPB000294 Vitamin K-dependent carboxylation/gamma-carboxyglutamic (GLA) domain
    IPB001254 Serine protease
    IPB001314 Chymotrypsin serine protease family (S1) signature
    IPB001438 Type II EGF-like signature


    UniProtKB/Swiss-Prot: FA10_HUMAN, P00742
    Similarity: Belongs to the peptidase S1 family
    Similarity: Contains 2 EGF-like domains
    Similarity: Contains 1 Gla (gamma-carboxy-glutamate) domain
    Similarity: Contains 1 peptidase S1 domain


    F10 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: FA10_HUMAN, P00742
    Function: Factor Xa is a vitamin K-dependent glycoprotein that converts prothrombin to thrombin in the presence of
    factor Va, calcium and phospholipid during blood clotting
    Catalytic activity: Selective cleavage of Arg- -Thr and then Arg- -Ile bonds in prothrombin to form thrombin
    Enzyme regulation: Inhibited by SERPINA5 and SERPINA10

         Genatlas biochemistry entry for F10:
    coagulation factor X (Stuart Prower),vitamin K-dependent

         Enzyme Numbers (IUBMB): EC 3.4.21.61 2 EC 3.4.212

         Gene Ontology (GO): 5 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003824catalytic activity ----
    GO:0004252serine-type endopeptidase activity TAS--
    GO:0005509calcium ion binding IEA--
    GO:0005515protein binding IPI6323392
    GO:0005543phospholipid binding IDA17469850
         
    F10 for ontologies           About GeneDecksing


    Phenotypes:
         4 MGI mutant phenotypes (inferred from 3 alleles(MGI details for F10):
     cardiovascular system  homeostasis/metabolism  mortality/aging  reproductive system 

    F10 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-outs for F10: F10tm1Edr F10tm1Ccmt

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for F10
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for F10

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for F10
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for F10

    miRNA
    Products:
        
    miRTarBase miRNAs that target F10:
    hsa-mir-335-5p (MIRT016852)

    Block miRNA regulation of human, mouse, rat F10 using miScript Target Protectors
    Search for qRT-PCR Assays for microRNAs that regulate F10
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for F10
    Predesigned siRNA for gene silencing in human, mouse, rat F10

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for F10

    Clone
    Products:
         
    OriGene clones in human, mouse for F10 (see all 6)
    OriGene ORF clones in mouse, rat for F10
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: F10 (NM_014206)
    Sino Biological Human cDNA Clone for F10
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for F10
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat F10

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for F10
    Browse ESI BIO Cell Lines and PureStem Progenitors for F10 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for F10


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Subcellular locations from UniProtKB/Swiss-Prot
    FA10_HUMAN, P00742: Secreted
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    extracellular5
    endoplasmic reticulum4
    golgi apparatus4
    plasma membrane3
    nucleus1

    Gene Ontology (GO): Selected cellular component terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region TAS--
    GO:0005788endoplasmic reticulum lumen TAS--
    GO:0005796Golgi lumen TAS--
    GO:0005886plasma membrane TAS--
    GO:0016020membrane ----

    F10 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
    About This Section

    TryGeneCards Plus

    SuperPaths for F10 About   (see all 6)  
    See pathways by source

    SuperPathContained pathways About
    1Formation of Fibrin Clot (Clotting Cascade)
    Formation of Fibrin Clot (Clotting Cascade)0.51
    Intrinsic Pathway0.00
    Blood Coagulation Signaling Pathways0.51
    Extrinsic Prothrombin Activation Pathway0.00
    Blood Clotting Cascade0.42
    Extrinsic Pathway0.00
    Common Pathway0.00
    2PTM- gamma carboxylation, hypusine formation and arylsulfatase activation
    PTM- gamma carboxylation, hypusine formation and arylsulfatase activation0.31
    Removal of aminoterminal propeptides from gamma-carboxylated proteins0.00
    Warfarin Pathway, Pharmacodynamics0.31
    Gamma-carboxylation of protein precursors0.00
    Gamma-carboxylation, transport, and amino-terminal cleavage of proteins0.00
    Transport of gamma-carboxylated protein precursors from the endoplasmic reticulum to the Golgi apparatus0.00
    3Complement and coagulation cascades
    Complement and coagulation cascades0.71
    Complement and Coagulation Cascades0.71
    4Collagen biosynthesis and modifying enzymes
    Intrinsic Prothrombin Activation Pathway0.39
    Blood Coagulation Cascade0.38
    5Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein
    Post-translational protein modification0.43
    Metabolism of proteins0.30

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 R&D Systems Pathway for F10
        Blood Coagulation Signaling Pathways

    3 Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for F10
        Extrinsic Prothrombin Activation Pathway
    Blood Coagulation Cascade
    Intrinsic Prothrombin Activation Pathway

    2 BioSystems Pathways for F10
        Blood Clotting Cascade
    Complement and Coagulation Cascades


    Selected Reactome Pathways for F10 (see all 6)
        Extrinsic Pathway
    Intrinsic Pathway
    Transport of gamma-carboxylated protein precursors from the endoplasmic reticulum to the Golgi apparatus
    Removal of aminoterminal propeptides from gamma-carboxylated proteins
    Gamma-carboxylation of protein precursors

    1 PharmGKB Pathway for F10
        Warfarin Pathway, Pharmacodynamics

    1 Kegg Pathway  (Kegg details for F10):
        Complement and coagulation cascades


    F10 for pathways           About GeneDecksing

        Pathway & Disease-focused RT2 Profiler PCR Array including F10: 
              Hypoxia Signaling Pathway in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for F10

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for F10 (P007422, 3 ENSP000003647094) via UniProtKB, MINT, STRING, and/or I2D (see all 40)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    MGST3O148803, ENSP000003568594I2D: score=3 STRING: ENSP00000356859
    F5P122593, ENSP000003567714I2D: score=2 STRING: ENSP00000356771
    F7P087093, ENSP000003647314I2D: score=2 STRING: ENSP00000364731
    F8P004513, ENSP000003533934I2D: score=2 STRING: ENSP00000353393
    HIST1H1CP164033, ENSP000003395664I2D: score=2 STRING: ENSP00000339566
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 9):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006508proteolysis TAS--
    GO:0007596blood coagulation TAS--
    GO:0007597blood coagulation, intrinsic pathway TAS--
    GO:0007598blood coagulation, extrinsic pathway TAS--
    GO:0017187peptidyl-glutamic acid carboxylation TAS--

    F10 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
    About This Section

    TryGeneCards Plus
    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for F10 (FA10)

    2 HMDB Compounds for F10    About this table
    CompoundSynonyms CAS #PubMed Ids
    CalciumCa (see all 2)7440-70-2--
    MenadioneVitamin K3: 1,4-Dihydro-1,4-dioxo-2-methylnaphthalene (see all 49)58-27-5--

    Selected DrugBank Compounds for F10 (see all 39)    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    Coagulation Factor IXChristmas factor (see all 4)9001-28-9targetactivator1391956 659613 9079657 11752352 8083242 10919405 10933803
    Antihemophilic FactorAHF (see all 3)--targetactivator14285227 6436416 236567 11891806 13801371
    Coagulation factor VIIaCoagulation factor VII precursor (see all 5)9001-25-6target--5969560 13713641 14227143 13621053 13801371
    EnoxaparinLMWH (see all 2)9005-49-6targetinhibitor17567541 17474542 16187968 17509040 15675440
    HeparinAlpha-Heparin (see all 8)9005-49-6targetinhibitor17004727 17118432 3155697 11369259
    Apixaban-- 503612-47-3targetinhibitor17371192 18393142
    Menadione2-Methyl-1,4-Naphthalenedione (see all 7)58-27-5targetactivator17139284 17016423
    Rivaroxaban-- 366789-02-8targetantagonist20135071 20424181
    (2R)-2-(5-CHLORO-2-THIENYL)-N-{(3S)-1-[(1S)-1-METHYL-2-MORPHOLIN-4-YL-2-OXOETHYL]-2-OXOPYRROLIDIN-3-YL}PROPENE-1-SULFONAMIDE-- --target--10592235
    (2R,4R)-N~1~-(4-CHLOROPHENYL)-N~2~-[2-FLUORO-4-(2-OXOPYRIDIN-1(2H)-YL)PHENYL]-4-METHOXYPYRROLIDINE-1,2-DICARBOXAMIDE-- --target--10592235

    Selected Novoseek inferred chemical compound relationships for F10 gene (see all 115)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    rivaroxaban 94.4 125 17938768 (3), 18307374 (3), 20139357 (3), 17595891 (3) (see all 77)
    fondaparinux 94.3 179 12871328 (3), 15744699 (3), 15171960 (2), 12501872 (2) (see all 99)
    apixaban 91.7 42 19851712 (5), 18315548 (3), 17868430 (2), 18393142 (1) (see all 29)
    heparin 88.8 634 12871328 (6), 11009624 (5), 9642241 (5), 19967150 (5) (see all 99)
    heparin pentasaccharide 88.6 11 12353073 (2), 11854268 (1), 14532267 (1), 12871328 (1) (see all 8)
    dabigatran etexilate 86.4 16 19601856 (1), 19550318 (1), 18473863 (1), 19803538 (1) (see all 13)
    otamixaban 83 12 17139573 (3), 17178269 (2), 16493482 (2), 19717184 (1) (see all 8)
    hirudin 82.4 65 12883328 (3), 7740455 (3), 8218854 (2), 2096492 (2) (see all 42)
    antistasin 82.1 23 7740449 (2), 9804761 (2), 8218854 (2), 1990979 (2) (see all 12)
    gamma-carboxyglutamic acid 81.4 47 8226763 (4), 17387172 (3), 9780208 (2), 8355279 (1) (see all 19)



    F10 for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
    About This Section

    TryGeneCards Plus

    REFSEQ mRNAs for F10 gene: 
    NM_000504.3  

    Unigene Cluster for F10:

    Coagulation factor X
    Hs.361463  [show with all ESTs]
    Unigene Representative Sequence: BC040125
    7 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000409306 ENST00000375551(uc001vsy.3) ENST00000375559(uc001vsx.3)
    ENST00000477269 ENST00000483537 ENST00000410083(uc010agq.1) ENST00000498455

    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat F10 using miScript Target Protectors
    Search for qRT-PCR Assays for microRNAs that regulate F10
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for F10
    Predesigned siRNA for gene silencing in human, mouse, rat F10
    Clone
    Products:
         
    OriGene clones in human, mouse for F10 (see all 6)
    OriGene ORF clones in mouse, rat for F10
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: F10 (NM_014206)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for F10
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat F10
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for F10
    OriGene qSTAR qPCR primer pairs in human, mouse for F10
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat F10
      QuantiTect SYBR Green Assays in human, mouse, rat F10
      QuantiFast Probe-based Assays in human, mouse, rat F10

    Additional mRNA sequence: 

    AK310772.1 AK310775.1 AK313798.1 BC040125.1 BC046125.1 K01886.1 K03194.1 M22613.1 
    M57285.1 

    8 DOTS entries:

    DT.313355  DT.97856616  DT.100676340  DT.97861708  DT.120640635  DT.120780844  DT.97781688  DT.121305757 

    Selected AceView cDNA sequences (see all 72):

    CD518821 CB162539 M22613 BM709916 CR603372 CD014138 BC046125 CR607773 
    K01886 BU849949 BU846186 BM987312 BC040125 CR623031 BQ027447 CD013940 
    CA444781 NM_000504 CD676150 BP339855 M57285 BQ018853 CB158437 CD608655 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for F10 (see all 6)    About this scheme

    ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7a · 7b ^ 8a · 8b · 8c ^ 9a · 9b · 9c
    SP1:                          -                 -                 -                                       
    SP2:                          -                 -     -           -                                       
    SP3:                          -                 -                                                         
    SP4:                                            -                 -                 -                     
    SP5:                                                              -                                       


    ECgene alternative splicing isoforms for F10

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TryGeneCards Plus

    F10 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CCCCGGAGGT
    F10 Expression
    About this image


    F10 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 7) fully expand
     
     NULL (Uncategorized)    fully expand to see all 2 entries
             Definitive endoderm-like cells
     
     Blood (Cardiovascular System)    fully expand to see all 2 entries
             Monocytes Peripheral Blood
     
     Skeletal Muscle (Muscoskeletal System)    fully expand to see all 2 entries
             Muscle Progenitor Cells Mandibular Arch Muscles
     
     Heart (Cardiovascular System)
             Cardiac Crescent Cells Cardiac Crescent
     
     Ovary (Reproductive System)
             Granulosa Cells Primary Follicle
    F10 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    F10 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.361463

    UniProtKB/Swiss-Prot: FA10_HUMAN, P00742
    Tissue specificity: Plasma; synthesized in the liver

        Pathway & Disease-focused RT2 Profiler PCR Array including F10: 
              Hypoxia Signaling Pathway in human mouse rat

    Primer
    Products:
    OriGene qPCR primer pairs and template standards for F10
    OriGene qSTAR qPCR primer pairs in human, mouse for F10
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat F10
    QuantiTect SYBR Green Assays in human, mouse, rat F10
    QuantiFast Probe-based Assays in human, mouse, rat F10
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for F10

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    TryGeneCards Plus

    This gene was present in the common ancestor of animals.

    Orthologs for F10 gene from Selected species (see all 16)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia F101 , 5 coagulation factor X1, 5 78.04(n)1
    77.54(a)1
      8 (5.73 cM)5
    140581  NM_007972.41  NP_031998.31 
     130373085 
    chicken
    (Gallus gallus)
    Aves F101 coagulation factor X 60.03(n)
    58.6(a)
      395876  NM_205022.1  NP_990353.1 
    lizard
    (Anolis carolinensis)
    Reptilia F106
    coagulation factor X
    48(a)
    1 ↔ 1
    3(105945146-105965778)
    African clawed frog
    (Xenopus laevis)
    Amphibia MGC684542 hypothetical protein MGC68454 74.97(n)    BC060330.1 
    zebrafish
    (Danio rerio)
    Actinopterygii f102 coagulation factor X 74.88(n)   282670  BC056804.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG118361 , 3 serine-type endopeptidase3
    CG118361
    39(a)3
    49.21(n)1
    39.83(a)1
      96B203
    430071  NM_001170247.31  NP_001163718.31 


    ENSEMBL Gene Tree for F10 (if available)
    TreeFam Gene Tree for F10 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

    TryGeneCards Plus
    Paralogs for F10 gene
    PROZ2  C1S2  C1R2  C1RL2  F92  MASP12  F22  HPR2  
    F72  HP2  PROC2  MASP22  
    16 SIMAP similar genes for F10 using alignment to 6 protein entries:     FA10_HUMAN (see all proteins):
    PRRG1    PROS1    PRRG3    PROC1    F9    KLK4
    F9 p22    PRSS1    factor IX F9    F2    PRRG2    PRSS2
    TRY8    F7    PROC    KLK9

    F10 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

    TryGeneCards Plus

    Selected SNPs for F10 (see all 806)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 13 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1997789161,2,,4
    Factor X deficiency (FA10D)4 --94741199(+) CAGCTG/TCAAGC 2 C F mis10--------
    VAR_0654494
    Factor X deficiency (FA10D)4--see VAR_0654492 C R mis40--------
    VAR_0654354
    Factor X deficiency (FA10D)4--see VAR_0654352 C Y mis40--------
    VAR_0654424
    Factor X deficiency (FA10D)4--see VAR_0654422 E K mis40--------
    VAR_0654364
    Factor X deficiency (FA10D)4--see VAR_0654362 C Y mis40--------
    VAR_0654514
    Factor X deficiency (FA10D)4--see VAR_0654512 G R mis40--------
    VAR_0654454
    Factor X deficiency (FA10D)4--see VAR_0654452 R C mis40--------
    VAR_0654374
    Factor X deficiency (FA10D)4--see VAR_0654372 G R mis40--------
    VAR_0654414
    Factor X deficiency (FA10D)4--see VAR_0654412 V M mis40--------
    VAR_0654384
    Factor X deficiency (FA10D)4--see VAR_0654382 E K mis40--------

    HapMap Linkage Disequilibrium report for F10 (113777113 - 113803843 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for F10 (see all 16):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv1499407CNV Deletion17803354
    esv2678487CNV Deletion23128226
    esv2748261CNV Deletion23290073
    nsv901049CNV Loss21882294
    nsv901039CNV Loss21882294
    dgv1800n71CNV Loss21882294
    nsv832724CNV Loss17160897
    dgv1797n71CNV Loss21882294
    dgv1798n71CNV Loss21882294
    nsv901065CNV Loss21882294

    Human Gene Mutation Database (HGMD): F10
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing F10
    DNA2.0 Custom Variant and Variant Library Synthesis for F10

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TryGeneCards Plus
    OMIM gene information: 613872   
    OMIM disorders: 227600  
    UniProtKB/Swiss-Prot: FA10_HUMAN, P00742
  • Factor X deficiency (FA10D) [MIM:227600]: A hemorrhagic disease with variable presentation. Affected
    individuals can manifest prolonged nasal and mucosal hemorrhage, menorrhagia, hematuria, and occasionally
    hemarthrosis. Some patients do not have clinical bleeding diathesis. Note=The disease is caused by mutations
    affecting the gene represented in this entry

  • Selected diseases for F10 (see all 96):    
    About MalaCards
    factor x deficiency    antithrombin iii deficiency    hemarthrosis    quebec platelet disorder
    mild hemophilia a    heparin-induced thrombocytopenia    scott syndrome    carotid artery thrombosis
    hemophilia b    hemophilia    acquired hemophilia    venous thromboembolism
    al amyloidosis    factor vii deficiency    warfarin sensitivity    thrombasthenia
    glanzmann's thrombasthenia    dysfibrinogenemia    hemorrhagic disease    afibrinogenemia

    4 diseases from the University of Copenhagen DISEASES database for F10:
    Carney complex     Pulmonary embolism     Factor X deficiency     Disseminated intravascular coagulation

    F10 for disorders           About GeneDecksing

    Selected Novoseek inferred disease relationships for F10 gene (see all 85)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    factor x deficiency 81 3 9799000 (1), 8449937 (1), 15569527 (1)
    thromboembolism 80.6 54 16409461 (2), 19485937 (2), 16241946 (2), 14650860 (2) (see all 44)
    scott syndrome 76.1 5 1730083 (2), 9054648 (1), 19408196 (1), 11421293 (1)
    thrombosis 76 71 10604970 (2), 11554940 (2), 12829728 (2), 15338955 (2) (see all 54)
    deep vein thrombosis 71.1 8 15091002 (1), 15554723 (1), 8029801 (1), 12750119 (1) (see all 8)
    arterial thrombosis 69.2 17 10813384 (1), 11177336 (1), 11342132 (1), 17729190 (1) (see all 14)
    bleeding 67.9 53 11554940 (2), 19598069 (2), 12829728 (2), 14633255 (2) (see all 44)
    venous thrombosis 62.8 25 11434677 (3), 9241747 (2), 9336303 (1), 10813384 (1) (see all 14)
    coagulopathy 62.1 15 11554940 (2), 19598069 (2), 14995986 (1), 12161341 (1) (see all 11)
    hemophilia a 60.9 3 2130929 (1), 14717973 (1), 16409469 (1)

    Genatlas disease: F10
    bleeding diathesis (FX deficiency)

    Genetic Association Database (GAD): F10
    Human Genome Epidemiology (HuGE) Navigator: F10 (17 documents)

    Export disorders for F10 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    TryGeneCards Plus

    PubMed articles for F10 gene, integrated from 10 sources (see all 1590):
    (articles sorted by number of sources associating them with F10)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Characterization of a homozygous Gly11Val mutation in the Gla domain of coagulation factor X. (PubMed id 19135706)1, 2, 9 Chafa O....LeBonniec B.F. (Thromb. Res. 2009)
    2. Activation-dependent exposure of the inter-EGF sequence Leu83-Leu88 in factor Xa mediates ligand binding to effector cell protease receptor-1. (PubMed id 9079657)1, 7, 9 Ambrosini G....Altieri D.C. (J. Biol. Chem. 1997)
    3. Monitoring Unfractionated Heparin (UFH) therapy: which Anti-Factor Xa assay is appropriate? (PubMed id 17118432)1, 7, 9 Ignjatovic V....Monagle P. (Thromb. Res. 2007)
    4. Analysis of the novel factor X gene mutation Glu51Lys in two families with factor X-Riyadh anomaly. (PubMed id 17393015)1, 2, 9 Al-Hilali A....Herrmann F.H. (Thromb. Haemost. 2007)
    5. Structural basis for chemical inhibition of human blood coagulation factor Xa. (PubMed id 9618463)1, 2, 9 Kamata K.... Kim S.H. (Proc. Natl. Acad. Sci. U.S.A. 1998)
    6. Structure of human des(1-45) factor Xa at 2.2-A resolution. (PubMed id 8355279)1, 2, 9 Padmanabhan K.... Kisiel W. (J. Mol. Biol. 1993)
    7. Cloning and expression in COS-1 cells of a full-length cDNA encoding human coagulation factor X. (PubMed id 1902434)1, 2, 9 Messier T.L.... Church W.R. (Gene 1991)
    8. Basis for the specificity and activation of the serpin protein Z- dependent proteinase inhibitor (ZPI) as an inhibitor of membrane- associated factor Xa. (PubMed id 20427285)1, 2 Huang X.... Gettins P.G. (J. Biol. Chem. 2010)
    9. Maternal and fetal genetic associations of PTGER3 and PON1 with preterm birth. (PubMed id 20140262)1, 4 Ryckman K.K....Jacobsson B. (PLoS ONE 2010)
    10. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1, 4 Bailey S.D....Anand S. (Diabetes Care 2010)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

    TryGeneCards Plus
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

    TryGeneCards Plus
    Entrez Gene: 2159 HGNC: 3528 AceView: F10 Ensembl:ENSG00000126218 euGenes: HUgn2159
    ECgene: F10 Kegg: 2159 H-InvDB: F10

    (According to HUGE)
    About This Section

    TryGeneCards Plus
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

    TryGeneCards Plus
    NameDescription
    PharmGKB entry for F10 Pharmacogenomics, SNPs, Pathways
    Wikipedia http://en.wikipedia.org/wiki/Factor_X
    SeattleSNPshttp://pga.gs.washington.edu/data/f10/

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus
    Patent Information for F10 gene:
    Search GeneIP for patents involving F10

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

    TryGeneCards Plus

     
     EMD Millipore genomic analysis products

      
     Antibodies for F10 (Coagulation Factor X)   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Enzyme Activity Assays/Reagents  
     Browse ELISpot/FluoroSpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Luminex Assays  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Recombinant/Natural Proteins for F10 (Coagulation Factor X)   Browse Stem Cell Products  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     OriGene Antibodies for F10   OriGene RNAi products in human, mouse, rat for F10  
     OriGene qPCR primer pairs and template standards for F10   OriGene Protein Over-expression Lysate for F10  
     OriGene MassSpec something-or-other for F10   OriGene clones in human, mouse for F10  
     OriGene qSTAR qPCR primer pairs in human, mouse for F10   OriGene Purified Protein for F10  
     OriGene ORF clones in mouse, rat for F10   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for F10   OriGene Custom Protein Services for F10  

     
     
     Block miRNA regulation of human, mouse, rat F10 using miScript Target Protectors SeqTarget long-range PCR primers for resequencing F10
     DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat F10 Predesigned siRNA for gene silencing in human, mouse, rat F10
     QuantiFast Probe-based Assays in human, mouse, rat F10 QuantiTect SYBR Green Assays in human, mouse, rat F10
     PCR Arrays including human, mouse, rat F10 Search Chromatin IP Primers for F10
     Pre-validated RT2 qPCR Primer Assay in human, mouse, rat F10  GeneGlobe Interaction Network for F10
     Regulatory tfbs in F10 promoter
     GenScript Custom Purified and Recombinant Proteins Services for F10 GenScript cDNA clones with any tag delivered in your preferred vector for F10
     GenScript Custom Assay Services for F10 GenScript Custom overexpressing Cell Line Services for F10
     CloneReady with Over 120,000 Genes  Gene Synthesis: Any Gene in Any Vector
     Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
     Plasmid Preparation Custom Peptide Services
     Search for Antibodies & Assays

     Search Tocris compounds for F10 (FA10)
     Proteins for F10
     Cell Lysates for F10
     cDNA Clones for F10
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Proteins for F10
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

     Novus Tissue Slides
     F10 antibodies
     F10 proteins
     F10 lysates
     Antibodies for F10
     See all of Abcam's Antibodies, Kits and Proteins for F10
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins
     Proteins for F10
     Antibodies for F10
     ELISAs for F10
     CLIAs for F10



     Browse ESI BIO Cell Lines and PureStem Progenitors for F10
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for F10
     Browse SwitchGear 3'UTR luciferase reporter plasmids for F10
     SwitchGear Promoter luciferase reporter plasmids for F10
     ThermoFisher Antibody for F10
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat F10
     inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for F10
     inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for F10
     LSBio Antibodies in human, mouse, rat for F10
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
     Browse compounds at ApexBio
           
    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014

    View Random Gene

    Category
    (GIFtS: )
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      F10 gene at Home site.
    Version: 3.12.164 25 Aug 2014
    hostname: 356980-web2.xennexinc.com index build: 126 solr: 1.4