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Aliases for F10 Gene

Aliases for F10 Gene

  • Coagulation Factor X 2 3 5
  • Stuart-Prower Factor 3 4
  • EC 3.4.21.6 4 61
  • Prothrombinase 3
  • Stuart Factor 4
  • Factor Xa 3
  • EC 3.4.21 61
  • FXA 3
  • FX 3

External Ids for F10 Gene

Previous GeneCards Identifiers for F10 Gene

  • GC13P112387
  • GC13P108414
  • GC13P112863
  • GC13P111725
  • GC13P112825
  • GC13P113777
  • GC13P094215

Summaries for F10 Gene

Entrez Gene Summary for F10 Gene

  • This gene encodes the vitamin K-dependent coagulation factor X of the blood coagulation cascade. This factor undergoes multiple processing steps before its preproprotein is converted to a mature two-chain form by the excision of the tripeptide RKR. Two chains of the factor are held together by 1 or more disulfide bonds; the light chain contains 2 EGF-like domains, while the heavy chain contains the catalytic domain which is structurally homologous to those of the other hemostatic serine proteases. The mature factor is activated by the cleavage of the activation peptide by factor IXa (in the intrisic pathway), or by factor VIIa (in the extrinsic pathway). The activated factor then converts prothrombin to thrombin in the presence of factor Va, Ca+2, and phospholipid during blood clotting. Mutations of this gene result in factor X deficiency, a hemorrhagic condition of variable severity. Alternative splicing results in multiple transcript variants encoding different isoforms that may undergo similar proteolytic processing to generate mature polypeptides. [provided by RefSeq, Aug 2015]

GeneCards Summary for F10 Gene

F10 (Coagulation Factor X) is a Protein Coding gene. Diseases associated with F10 include Factor X Deficiency and Hemorrhagic Disease. Among its related pathways are Collagen biosynthesis and modifying enzymes and Formation of Fibrin Clot (Clotting Cascade). GO annotations related to this gene include calcium ion binding and phospholipid binding. An important paralog of this gene is F9.

UniProtKB/Swiss-Prot for F10 Gene

  • Factor Xa is a vitamin K-dependent glycoprotein that converts prothrombin to thrombin in the presence of factor Va, calcium and phospholipid during blood clotting.

Gene Wiki entry for F10 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for F10 Gene

Genomics for F10 Gene

Regulatory Elements for F10 Gene

Enhancers for F10 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH13F113489 1.1 FANTOM5 Ensembl ENCODE 15.3 +370.0 370031 7.5 HDGF PKNOX1 CREB3L1 MLX ARID4B SIN3A FEZF1 DMAP1 ZNF2 ZNF207 TMCO3 TUBGCP3 F10 TMEM255B GRTP1 GAS6-AS1 DCUN1D2-AS LAMP1 ADPRHL1 GRTP1-AS1
GH13F113206 0.5 ENCODE 13.2 +86.0 86043 5.0 PKNOX1 CREB3L1 MLX ZFP64 ARID4B SIN3A FEZF1 DMAP1 ZNF2 YY1 TUBGCP3 PROZ TMEM255B F10 LINC01043 SPACA7 LINC01044 LINC00454 LDHBP1 GAS6-AS1
GH13F113447 0.2 ENCODE 13.1 +326.4 326359 2.5 ATF1 PKNOX1 ARNT ARID4B SIN3A ZNF121 SLC30A9 ELK1 ZNF143 KDM4B DCUN1D2 TMEM255B F10 TMCO3 ADPRHL1 LOC101928841
GH13F112586 0.4 ENCODE 13 -535.0 -534962 2.8 CREB3L1 MLX ZFP64 ARID4B SIN3A DMAP1 ZNF2 YY1 SLC30A9 ZNF207 TUBGCP3 LOC102724489 LOC105370369 LINC01043 F10 SPACA7 LINC01044 LDHBP1 DCUN1D2-AS GC13P112588
GH13F113175 1 Ensembl ENCODE 11.2 +55.7 55674 5.7 PKNOX1 JUN SIN3A ZIC2 ZFHX2 POLR2A FOS MAFK NFE2L2 EGR2 PROZ PCID2 CUL4A F10-AS1 KARSP2 F10 F7 GRTP1 GRTP1-AS1 ENSG00000269356
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around F10 on UCSC Golden Path with GeneCards custom track

Promoters for F10 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000520911 201 401 PKNOX1 ARID4B SIN3A DMAP1 ZNF48 YY1 SLC30A9 SP5 NFYC MXD4

Genomic Location for F10 Gene

Chromosome:
13
Start:
113,122,799 bp from pter
End:
113,149,529 bp from pter
Size:
26,731 bases
Orientation:
Plus strand

Genomic View for F10 Gene

Genes around F10 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
F10 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for F10 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for F10 Gene

Proteins for F10 Gene

  • Protein details for F10 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P00742-FA10_HUMAN
    Recommended name:
    Coagulation factor X
    Protein Accession:
    P00742
    Secondary Accessions:
    • Q14340

    Protein attributes for F10 Gene

    Size:
    488 amino acids
    Molecular mass:
    54732 Da
    Quaternary structure:
    • The two chains are formed from a single-chain precursor by the excision of two Arg residues and are held together by 1 or more disulfide bonds. Forms a heterodimer with SERPINA5.

    Three dimensional structures from OCA and Proteopedia for F10 Gene

neXtProt entry for F10 Gene

Selected DME Specific Peptides for F10 Gene

P00742:
  • RANSFLEE
  • GECPWQA
  • LRLKTPITFR
  • DACQGDSGG
  • SWGEGCA
  • LERECMEE
  • EDACQGDSGGPHVTRF
  • CQGDSGGP
  • DTYFVTGIVSWGEGCARKGK
  • NVAPACLP
  • FCGGTIL
  • TGIVSWG
  • QKTGIVSGFGRTHE

Post-translational modifications for F10 Gene

  • N- and O-glycosylated. O-glycosylated with core 1 or possibly core 8 glycans.
  • The activation peptide is cleaved by factor IXa (in the intrinsic pathway), or by factor VIIa (in the extrinsic pathway).
  • The iron and 2-oxoglutarate dependent 3-hydroxylation of aspartate and asparagine is (R) stereospecific within EGF domains.
  • The vitamin K-dependent, enzymatic carboxylation of some glutamate residues allows the modified protein to bind calcium.
  • Glycosylation at Thr 199, Thr 211, Asn 221, Asn 231, and Thr 483
  • Modification sites at PhosphoSitePlus

Other Protein References for F10 Gene

Antibody Products

  • R&D Systems Antibodies for F10 (Coagulation Factor X)

Domains & Families for F10 Gene

Gene Families for F10 Gene

Suggested Antigen Peptide Sequences for F10 Gene

Graphical View of Domain Structure for InterPro Entry

P00742

UniProtKB/Swiss-Prot:

FA10_HUMAN :
  • Contains 2 EGF-like domains.
  • Belongs to the peptidase S1 family.
Domain:
  • Contains 2 EGF-like domains.
  • Contains 1 Gla (gamma-carboxy-glutamate) domain.
  • Contains 1 peptidase S1 domain.
Family:
  • Belongs to the peptidase S1 family.
genes like me logo Genes that share domains with F10: view

Function for F10 Gene

Molecular function for F10 Gene

GENATLAS Biochemistry:
coagulation factor X (Stuart Prower),vitamin K-dependent
UniProtKB/Swiss-Prot CatalyticActivity:
Selective cleavage of Arg- -Thr and then Arg- -Ile bonds in prothrombin to form thrombin.
UniProtKB/Swiss-Prot EnzymeRegulation:
Inhibited by SERPINA5 and SERPINA10.
UniProtKB/Swiss-Prot Function:
Factor Xa is a vitamin K-dependent glycoprotein that converts prothrombin to thrombin in the presence of factor Va, calcium and phospholipid during blood clotting.

Enzyme Numbers (IUBMB) for F10 Gene

Gene Ontology (GO) - Molecular Function for F10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004252 serine-type endopeptidase activity TAS --
GO:0005509 calcium ion binding IEA --
GO:0005515 protein binding IPI 6323392
GO:0005543 phospholipid binding IDA 17469850
GO:0008233 peptidase activity IEA --
genes like me logo Genes that share ontologies with F10: view
genes like me logo Genes that share phenotypes with F10: view

Human Phenotype Ontology for F10 Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Models for F10 Gene

MGI Knock Outs for F10:
  • F10 tm1Ccmt
  • F10 tm1b(EUCOMM)Hmgu
  • F10 tm1Edr

Animal Model Products

  • Taconic Biosciences Mouse Models for F10

Inhibitory RNA Products

Flow Cytometry Products

No data available for Transcription Factor Targets and HOMER Transcription for F10 Gene

Localization for F10 Gene

Subcellular locations from UniProtKB/Swiss-Prot for F10 Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for F10 Gene COMPARTMENTS Subcellular localization image for F10 gene
Compartment Confidence
endoplasmic reticulum 5
extracellular 5
golgi apparatus 5
plasma membrane 5
cytosol 1
nucleus 1

Gene Ontology (GO) - Cellular Components for F10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA,TAS --
GO:0005788 endoplasmic reticulum lumen TAS --
GO:0005796 Golgi lumen TAS --
GO:0005886 plasma membrane TAS --
GO:0031233 intrinsic component of external side of plasma membrane IC 17469850
genes like me logo Genes that share ontologies with F10: view

Pathways & Interactions for F10 Gene

genes like me logo Genes that share pathways with F10: view

Gene Ontology (GO) - Biological Process for F10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006465 signal peptide processing TAS --
GO:0006508 proteolysis IEA --
GO:0006888 ER to Golgi vesicle-mediated transport TAS --
GO:0007596 blood coagulation IEA,TAS --
GO:0007597 blood coagulation, intrinsic pathway TAS --
genes like me logo Genes that share ontologies with F10: view

No data available for SIGNOR curated interactions for F10 Gene

Drugs & Compounds for F10 Gene

(127) Drugs for F10 Gene - From: DrugBank, ApexBio, DGIdb, HMDB, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Heparin Approved, Investigational Pharma Antagonist, cofactor, Target, inhibitor 812,256
Apixaban Approved Pharma inhibitor, Target Factor Xa inhibitor 134
Rivaroxaban Approved Pharma Target, antagonist Factor Xa inhibitor 244
Edoxaban Approved Pharma Target, inhibitor Factor Xa inhibitor 51
Menadione Approved Nutra inhibitor, Target, activator 230

(53) Additional Compounds for F10 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs

(11) ApexBio Compounds for F10 Gene

Compound Action Cas Number
5-R-Rivaroxaban Factor Xa (FXa) inhibitor 865479-71-6
Apixaban Factor Xa inhibitor 503612-47-3
Betrixaban Factor Xa inhibitor 330942-05-7
BIBR 953 (Dabigatran, Pradaxa) Thrombin inhibitor,potent,reversible and direct 211914-51-1
BIBR-1048 Thrombin inhibitor 211915-06-9
CORM-3 Exhibits anti-inflammatory/cardioprotective effects 475473-26-8
Edoxaban Factor Xa inhibitor 480449-70-5
Edoxaban tosylate Fxa inhibitor 480449-71-6
Edoxaban tosylate monohydrate Oral factor Xa inhibitor 1229194-11-9
Otamixaban Direct factor Xa inhibitors,potent and selective 193153-04-7
Rivaroxaban Factor Xa inhibitor 366789-02-8
genes like me logo Genes that share compounds with F10: view

Transcripts for F10 Gene

Unigene Clusters for F10 Gene

Coagulation factor X:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for F10 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7a · 7b ^ 8a · 8b · 8c ^ 9a · 9b · 9c
SP1: - - -
SP2: - - - -
SP3: - -
SP4: - - -
SP5: -
SP6:

Relevant External Links for F10 Gene

GeneLoc Exon Structure for
F10
ECgene alternative splicing isoforms for
F10

Expression for F10 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for F10 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for F10 Gene

This gene is overexpressed in Liver (x12.2).

Protein differential expression in normal tissues from HIPED for F10 Gene

This gene is overexpressed in Serum (35.3), Plasma (16.0), and Synovial fluid (10.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for F10 Gene



Protein tissue co-expression partners for F10 Gene

NURSA nuclear receptor signaling pathways regulating expression of F10 Gene:

F10

SOURCE GeneReport for Unigene cluster for F10 Gene:

Hs.361463

mRNA Expression by UniProt/SwissProt for F10 Gene:

P00742-FA10_HUMAN
Tissue specificity: Plasma; synthesized in the liver.
genes like me logo Genes that share expression patterns with F10: view

Primer Products

Orthologs for F10 Gene

This gene was present in the common ancestor of animals.

Orthologs for F10 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia F10 34 35
  • 99.52 (n)
dog
(Canis familiaris)
Mammalia F10 34 35
  • 79.52 (n)
mouse
(Mus musculus)
Mammalia F10 34 16 35
  • 78.04 (n)
rat
(Rattus norvegicus)
Mammalia F10 34
  • 77.24 (n)
cow
(Bos Taurus)
Mammalia F10 34 35
  • 76.88 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia F10 35
  • 63 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia F10 35
  • 60 (a)
OneToOne
chicken
(Gallus gallus)
Aves F10 34 35
  • 60.03 (n)
lizard
(Anolis carolinensis)
Reptilia F10 35
  • 48 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia f10 34
  • 57.65 (n)
African clawed frog
(Xenopus laevis)
Amphibia MGC68454 34
zebrafish
(Danio rerio)
Actinopterygii f10 34 35
  • 58.1 (n)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.9593 34
fruit fly
(Drosophila melanogaster)
Insecta CG11836 36 34
  • 49.21 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP004570 34
  • 45.94 (n)
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 17 (a)
OneToMany
Species where no ortholog for F10 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for F10 Gene

ENSEMBL:
Gene Tree for F10 (if available)
TreeFam:
Gene Tree for F10 (if available)

Paralogs for F10 Gene

Paralogs for F10 Gene

genes like me logo Genes that share paralogs with F10: view

Variants for F10 Gene

Sequence variations from dbSNP and Humsavar for F10 Gene

SNP ID Clin Chr 13 pos Sequence Context AA Info Type
rs104894392 Factor X deficiency (FA10D) [MIM:227600], Pathogenic 113,149,146(+) TCGGG(C/T)GCACC downstream-variant-500B, reference, missense, utr-variant-3-prime
rs121964939 Factor X deficiency (FA10D) [MIM:227600] 113,129,541(+) ACCTC(A/G)AAAGA intron-variant, reference, missense
rs121964940 Factor X deficiency (FA10D) [MIM:227600] 113,149,197(+) AGGTG(C/T)CCTAC downstream-variant-500B, reference, missense, utr-variant-3-prime
rs121964941 Factor X deficiency (FA10D) [MIM:227600] 113,149,170(+) GGCAG(C/T)CCACC downstream-variant-500B, reference, missense, utr-variant-3-prime
rs121964942 Factor X deficiency (FA10D) [MIM:227600] 113,149,014(+) ACTTC(A/G)ACATC reference, synonymous-codon, missense

Structural Variations from Database of Genomic Variants (DGV) for F10 Gene

Variant ID Type Subtype PubMed ID
dgv3426n54 CNV gain 21841781
esv1499407 CNV deletion 17803354
esv2678487 CNV deletion 23128226
esv2748261 CNV deletion 23290073
esv3551140 CNV deletion 23714750
esv3551141 CNV deletion 23714750
nsv1046663 CNV gain 25217958
nsv1048814 CNV gain 25217958
nsv1051556 CNV gain 25217958
nsv1070202 CNV deletion 25765185
nsv1113614 CNV deletion 24896259
nsv518044 CNV gain 19592680
nsv563282 CNV loss 21841781
nsv563283 CNV loss 21841781
nsv563284 CNV loss 21841781
nsv563285 CNV loss 21841781
nsv818996 CNV gain 17921354
nsv826819 CNV gain 20364138
nsv832724 CNV loss 17160897
nsv951926 CNV deletion 24416366
nsv958120 CNV deletion 24416366

Variation tolerance for F10 Gene

Residual Variation Intolerance Score: 34.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.20; 39.76% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for F10 Gene

Human Gene Mutation Database (HGMD)
F10
SNPedia medical, phenotypic, and genealogical associations of SNPs for
F10

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for F10 Gene

Disorders for F10 Gene

MalaCards: The human disease database

(24) MalaCards diseases for F10 Gene - From: OMIM, ClinVar, GeneTests, Orphanet, Swiss-Prot, DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
factor x deficiency
  • disease, stuart-prower
hemorrhagic disease
  • hemorrhagic diathesis
carotid artery thrombosis
scott syndrome
  • platelet factor x receptor deficiency
hemarthrosis
  • haemarthrosis of shoulder joint
- elite association - COSMIC cancer census association via MalaCards
Search F10 in MalaCards View complete list of genes associated with diseases

UniProtKB/Swiss-Prot

FA10_HUMAN
  • Factor X deficiency (FA10D) [MIM:227600]: A hemorrhagic disease with variable presentation. Affected individuals can manifest prolonged nasal and mucosal hemorrhage, menorrhagia, hematuria, and occasionally hemarthrosis. Some patients do not have clinical bleeding diathesis. {ECO:0000269 PubMed:10468877, ECO:0000269 PubMed:10746568, ECO:0000269 PubMed:11248282, ECO:0000269 PubMed:11728527, ECO:0000269 PubMed:12574802, ECO:0000269 PubMed:12945883, ECO:0000269 PubMed:15075089, ECO:0000269 PubMed:15650540, ECO:0000269 PubMed:17393015, ECO:0000269 PubMed:19135706, ECO:0000269 PubMed:1973167, ECO:0000269 PubMed:1985698, ECO:0000269 PubMed:25313940, ECO:0000269 PubMed:26222694, ECO:0000269 PubMed:2790181, ECO:0000269 PubMed:7669671, ECO:0000269 PubMed:7860069, ECO:0000269 PubMed:8529633, ECO:0000269 PubMed:8845463, ECO:0000269 PubMed:8910490}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Genatlas disease for F10 Gene

bleeding diathesis (FX deficiency)

Relevant External Links for F10

Genetic Association Database (GAD)
F10
Human Genome Epidemiology (HuGE) Navigator
F10
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
F10
genes like me logo Genes that share disorders with F10: view

Publications for F10 Gene

  1. Characterization of a homozygous Gly11Val mutation in the Gla domain of coagulation factor X. (PMID: 19135706) Chafa O. … LeBonniec B.F. (Thromb. Res. 2009) 3 4 22 64
  2. Impaired prothrombinase activity of factor X Gly381Asp results in severe familial CRM+ FX deficiency. (PMID: 12574802) Pinotti M. … Bernardi F. (Thromb. Haemost. 2003) 3 4 22 64
  3. Structure of human des(1-45) factor Xa at 2.2-A resolution. (PMID: 8355279) Padmanabhan K. … Kisiel W. (J. Mol. Biol. 1993) 3 4 22 64
  4. Cloning and expression in COS-1 cells of a full-length cDNA encoding human coagulation factor X. (PMID: 1902434) Messier T.L. … Church W.R. (Gene 1991) 3 4 22 64
  5. Maternal and fetal genetic associations of PTGER3 and PON1 with preterm birth. (PMID: 20140262) Ryckman K.K. … Jacobsson B. (PLoS ONE 2010) 3 46 64

Products for F10 Gene

Sources for F10 Gene

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