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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

F10 Gene

protein-coding   GIFtS: 71
GCID: GC13P113777

Coagulation Factor X

Microbiology & Infectious Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Coagulation Factor X1 2     Factor Xa2
Stuart-Prower Factor2 3     prothrombinase2
EC 3.4.21.63 8     Stuart Factor3
FX2     EC 3.4.218
FXA2     

External Ids:    HGNC: 35281   Entrez Gene: 21592   Ensembl: ENSG000001262187   OMIM: 6138725   UniProtKB: P007423   

Export aliases for F10 gene to outside databases

Previous GC identifers: GC13P112387 GC13P108414 GC13P112863 GC13P111725 GC13P112825 GC13P094215


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for F10 Gene:
This gene encodes the vitamin K-dependent coagulation factor X of the blood coagulation cascade. This factor
undergoes multiple processing steps before its preproprotein is converted to a mature two-chain form by the
excision of the tripeptide RKR. Two chains of the factor are held together by 1 or more disulfide bonds; the
light chain contains 2 EGF-like domains, while the heavy chain contains the catalytic domain which is
structurally homologous to those of the other hemostatic serine proteases. The mature factor is activated by the
cleavage of the activation peptide by factor IXa (in the intrisic pathway), or by factor VIIa (in the extrinsic
pathway). The activated factor then converts prothrombin to thrombin in the presence of factor Va, Ca+2, and
phospholipid during blood clotting. Mutations of this gene result in factor X deficiency, a hemorrhagic condition
of variable severity. (provided by RefSeq, Jul 2008)

GeneCards Summary for F10 Gene: 
F10 (coagulation factor X) is a protein-coding gene. Diseases associated with F10 include factor x deficiency, and hemarthrosis, and among its related super-pathways are Formation of Fibrin Clot (Clotting Cascade) and Transport of gamma-carboxylated protein precursors from the endoplasmic reticulum to the Golgi apparatus. GO annotations related to this gene include serine-type endopeptidase activity and calcium ion binding. An important paralog of this gene is PAMR1.

UniProtKB/Swiss-Prot: FA10_HUMAN, P00742
Function: Factor Xa is a vitamin K-dependent glycoprotein that converts prothrombin to thrombin in the presence of
factor Va, calcium and phospholipid during blood clotting

Gene Wiki entry for F10 (Factor X) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000013.10  NT_027140.6  NC_018924.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the F10 gene promoter:
         E2F-4   c-Fos   E2F-1   E2F   AP-1   ATF-2   c-Jun   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidF10 promoter sequence
   Search SABiosciences Chromatin IP Primers for F10

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat F10


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 13q34   Ensembl cytogenetic band:  13q34   HGNC cytogenetic band: 13q34

F10 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
F10 gene location

GeneLoc information about chromosome 13         GeneLoc Exon Structure

GeneLoc location for GC13P113777:  view genomic region     (about GC identifiers)

Start:
113,777,113 bp from pter      End:
113,803,843 bp from pter
Size:
26,731 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: FA10_HUMAN, P00742 (See protein sequence)
Recommended Name: Coagulation factor X precursor  
Size: 488 amino acids; 54732 Da
Subunit: The two chains are formed from a single-chain precursor by the excision of two Arg residues and are held
together by 1 or more disulfide bonds. Forms a heterodimer with SERPINA5
Subcellular location: Secreted
6/125 PDB 3D structures from and Proteopedia for F10 (see all 125):
1C5M (3D)        1EZQ (3D)        1F0R (3D)        1F0S (3D)        1FAX (3D)        1FJS (3D)    
Secondary accessions: Q14340

Explore the universe of human proteins at neXtProt for F10: NX_P00742

Explore proteomics data for F10 at MOPED 

Post-translational modifications:

  • UniProtKB: The vitamin K-dependent, enzymatic carboxylation of some glutamate residues allows the modified protein to bind
    calcium
  • UniProtKB: N- and O-glycosylated. O-glycosylated with core 1 or possibly core 8 glycans
  • UniProtKB: The activation peptide is cleaved by factor IXa (in the intrinsic pathway), or by factor VIIa (in the extrinsic
    pathway)
  • UniProtKB: The iron and 2-oxoglutarate dependent 3-hydroxylation of aspartate and asparagine is (R) stereospecific within EGF
    domains
  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_P00742

  • 4/13 DME Specific Peptides for F10 (P00742) (see all 13)
     FCGGTIL  GECPWQA  SWGEGCA  TGIVSWG 

    F10 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    F10 Protein Expression
    REFSEQ proteins: NP_000495.1  
    ENSEMBL proteins: 
     ENSP00000387092   ENSP00000364701   ENSP00000364709   ENSP00000386320  
    Reactome Protein details: P00742
    Human Recombinant Protein Products for F10: 
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    Novus Biologicals F10 Lysate
    Sino Biological Recombinant Protein for F10
    Sino Biological Cell Lysate for F10 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for F10 

    Gene Ontology (GO): 5/7 cellular component terms (GO ID links to tree view) (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region TAS--
    GO:0005788endoplasmic reticulum lumen TAS--
    GO:0005796Golgi lumen TAS--
    GO:0005886plasma membrane TAS--
    GO:0016020membrane ----

    F10 for ontologies           About GeneDecksing



    F10 Antibody Products: 
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    Cloud-Clone Corp. ELISAs for F10 
    Cloud-Clone Corp. CLIAs for F10


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    5/12 InterPro protein domains (see all 12):
     IPR017857 Coagulation_fac_subgr_Gla_dom
     IPR001314 Peptidase_S1A
     IPR000742 EG-like_dom
     IPR000152 EGF-type_Asp/Asn_hydroxyl_site
     IPR018097 EGF_Ca-bd_CS

    Graphical View of Domain Structure for InterPro Entry P00742

    ProtoNet protein and cluster: P00742

    5/7 Blocks protein domains (see all 7):
    IPB000152 Aspartic acid and asparagine hydroxylation site
    IPB000294 Vitamin K-dependent carboxylation/gamma-carboxyglutamic (GLA) domain
    IPB001254 Serine protease
    IPB001314 Chymotrypsin serine protease family (S1) signature
    IPB001438 Type II EGF-like signature


    UniProtKB/Swiss-Prot: FA10_HUMAN, P00742
    Similarity: Belongs to the peptidase S1 family
    Similarity: Contains 2 EGF-like domains
    Similarity: Contains 1 Gla (gamma-carboxy-glutamate) domain
    Similarity: Contains 1 peptidase S1 domain


    F10 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: FA10_HUMAN, P00742
    Function: Factor Xa is a vitamin K-dependent glycoprotein that converts prothrombin to thrombin in the presence of
    factor Va, calcium and phospholipid during blood clotting
    Catalytic activity: Selective cleavage of Arg- -Thr and then Arg- -Ile bonds in prothrombin to form thrombin
    Enzyme regulation: Inhibited by SERPINA5 and SERPINA10

         Genatlas biochemistry entry for F10:
    coagulation factor X (Stuart Prower),vitamin K-dependent

         Enzyme Numbers (IUBMB): EC 3.4.21.61 2 EC 3.4.212

         Gene Ontology (GO): 5 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003824catalytic activity ----
    GO:0004252serine-type endopeptidase activity TAS--
    GO:0005509calcium ion binding IEA--
    GO:0005515protein binding IPI6323392
    GO:0005543phospholipid binding IDA17469850
         
    F10 for ontologies           About GeneDecksing


    Phenotypes:
         4 MGI mutant phenotypes (inferred from 3 alleles(MGI details for F10):
     cardiovascular system  homeostasis/metabolism  mortality/aging  reproductive system 

    F10 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-outs for F10: F10tm1Ccmt F10tm1Edr

       inGenious Targeting Laboratory - Custom generated mouse model solutions for F10 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for F10

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for F10 
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    Inhib. RNA
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    Clone
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    OriGene ORF clones in mouse, rat for F10
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                         Customized lentivirus expression plasmids for stable overexpression of F10 

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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for F10


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for F10 About   (see all 8)                                                                                              See pathways by source

    SuperPathContained pathways About
    1Formation of Fibrin Clot (Clotting Cascade)
    Formation of Fibrin Clot (Clotting Cascade)0.59
    Blood Coagulation Signaling Pathways0.51
    Intrinsic Pathway0.59
    Blood Clotting Cascade0.42
    2Gamma-carboxylation, transport, and amino-terminal cleavage of proteins
    Transport of gamma-carboxylated protein precursors from the endoplasmic reticulum to the Golgi apparatus0.89
    Gamma-carboxylation, transport, and amino-terminal cleavage of proteins0.82
    Removal of aminoterminal propeptides from gamma-carboxylated proteins0.89
    Warfarin Pathway, Pharmacodynamics0.67
    Gamma-carboxylation of protein precursors0.89
    Extrinsic Pathway0.30
    3Complement and coagulation cascades
    Complement and Coagulation Cascades0.71
    Complement and coagulation cascades0.71
    4Common Pathway
    Extrinsic Prothrombin Activation Pathway0.69
    Common Pathway0.69
    5Collagen biosynthesis and modifying enzymes
    Intrinsic Prothrombin Activation Pathway0.40
    Blood Coagulation Cascade0.39

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 R&D Systems Pathway for F10
        Blood Coagulation Signaling Pathways

    3 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for F10
        Extrinsic Prothrombin Activation Pathway
    Blood Coagulation Cascade
    Intrinsic Prothrombin Activation Pathway

    2 BioSystems Pathways for F10
        Blood Clotting Cascade
    Complement and Coagulation Cascades


    5/12        Reactome Pathways for F10 (see all 12)
        Hemostasis
    Extrinsic Pathway
    Intrinsic Pathway
    Removal of aminoterminal propeptides from gamma-carboxylated proteins
    Common Pathway

    1 PharmGKB Pathway for F10
        Warfarin Pathway, Pharmacodynamics

    1         Kegg Pathway  (Kegg details for F10):
        Complement and coagulation cascades


    F10 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for F10

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/35 Interacting proteins for F10 (P007422, 3 ENSP000003647094) via UniProtKB, MINT, STRING, and/or I2D (see all 35)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    MGST3O148803, ENSP000003568594I2D: score=3 STRING: ENSP00000356859
    F5P122593, ENSP000003567714I2D: score=2 STRING: ENSP00000356771
    F7P087093, ENSP000003647314I2D: score=2 STRING: ENSP00000364731
    F8P004513, ENSP000003533934I2D: score=2 STRING: ENSP00000353393
    HIST1H1CP164033, ENSP000003395664I2D: score=2 STRING: ENSP00000339566
    About this table

    Gene Ontology (GO): 5/9 biological process terms (GO ID links to tree view) (see all 9):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006508proteolysis TAS--
    GO:0007596blood coagulation TAS--
    GO:0007597blood coagulation, intrinsic pathway TAS--
    GO:0007598blood coagulation, extrinsic pathway TAS--
    GO:0017187peptidyl-glutamic acid carboxylation TAS--

    F10 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    F10 for compounds           About GeneDecksing

    EMD Millipore small molecules for F10:
    Small Molecule - inhibitor
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for F10 (FA10)

    2 HMDB Compounds for F10    About this table
    CompoundSynonyms CAS #PubMed Ids
    CalciumCa (see all 2)7440-70-2--
    MenadioneVitamin K3: 1,4-Dihydro-1,4-dioxo-2-methylnaphthalene (see all 49)58-27-5--

    10/39 DrugBank Compounds for F10 (see all 39)    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    Coagulation Factor IXChristmas factor (see all 4)9001-28-9targetactivator1391956 659613 9079657 11752352 8083242 10919405 10933803
    Antihemophilic FactorAHF (see all 3)--targetactivator14285227 6436416 236567 11891806 13801371
    Coagulation factor VIIaCoagulation factor VII precursor (see all 5)9001-25-6target--5969560 13713641 14227143 13621053 13801371
    EnoxaparinLMWH (see all 2)9005-49-6targetinhibitor17567541 17474542 16187968 17509040 15675440
    HeparinAlpha-Heparin (see all 8)9005-49-6targetinhibitor17004727 17118432 3155697 11369259
    Apixaban-- 503612-47-3targetinhibitor17371192 18393142
    Menadione2-Methyl-1,4-Naphthalenedione (see all 7)58-27-5targetactivator17139284 17016423
    Rivaroxaban-- 366789-02-8targetantagonist20135071 20424181
    (2R)-2-(5-CHLORO-2-THIENYL)-N-{(3S)-1-[(1S)-1-METHYL-2-MORPHOLIN-4-YL-2-OXOETHYL]-2-OXOPYRROLIDIN-3-YL}PROPENE-1-SULFONAMIDE-- --target--10592235
    (2R,4R)-N~1~-(4-CHLOROPHENYL)-N~2~-[2-FLUORO-4-(2-OXOPYRIDIN-1(2H)-YL)PHENYL]-4-METHOXYPYRROLIDINE-1,2-DICARBOXAMIDE-- --target--10592235

    10/115 Novoseek inferred chemical compound relationships for F10 gene (see all 115)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    rivaroxaban 94.4 125 17938768 (3), 18307374 (3), 20139357 (3), 17595891 (3) (see all 77)
    fondaparinux 94.3 179 12871328 (3), 15744699 (3), 15171960 (2), 12501872 (2) (see all 99)
    apixaban 91.7 42 19851712 (5), 18315548 (3), 17868430 (2), 18393142 (1) (see all 29)
    heparin 88.8 634 12871328 (6), 11009624 (5), 9642241 (5), 19967150 (5) (see all 99)
    heparin pentasaccharide 88.6 11 12353073 (2), 11854268 (1), 14532267 (1), 12871328 (1) (see all 8)
    dabigatran etexilate 86.4 16 19601856 (1), 19550318 (1), 18473863 (1), 19803538 (1) (see all 13)
    otamixaban 83 12 17139573 (3), 17178269 (2), 16493482 (2), 19717184 (1) (see all 8)
    hirudin 82.4 65 12883328 (3), 7740455 (3), 8218854 (2), 2096492 (2) (see all 42)
    antistasin 82.1 23 7740449 (2), 9804761 (2), 8218854 (2), 1990979 (2) (see all 12)
    gamma-carboxyglutamic acid 81.4 47 8226763 (4), 17387172 (3), 9780208 (2), 8355279 (1) (see all 19)

    Search CenterWatch for drugs/clinical trials and news about F10 / FA10

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
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    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for F10 gene: 
    NM_000504.3  

    Unigene Cluster for F10:

    Coagulation factor X
    Hs.361463  [show with all ESTs]
    Unigene Representative Sequence: BC040125
    7 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000409306 ENST00000375551(uc001vsy.3) ENST00000375559(uc001vsx.3)
    ENST00000477269 ENST00000483537 ENST00000410083(uc010agq.1) ENST00000498455

    Congresses - knowledge worth sharing:  
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

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      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat F10

    Additional mRNA sequence: 

    AK310772.1 AK310775.1 AK313798.1 BC040125.1 BC046125.1 K01886.1 K03194.1 M22613.1 
    M57285.1 

    8 DOTS entries:

    DT.313355  DT.97856616  DT.100676340  DT.97861708  DT.120640635  DT.120780844  DT.97781688  DT.121305757 

    24/72 AceView cDNA sequences (see all 72):

    CD676150 BM709916 BP339855 CA444781 CD518821 BM987312 CB158437 CD013940 
    BU849949 BU846186 CB162539 BC040125 NM_000504 M22613 CD014138 CR603372 
    BQ018853 BC046125 CR607773 BQ027447 M57285 K01886 CR623031 AL570383 

    GeneLoc Exon Structure

    5/6 Alternative Splicing Database (ASD) splice patterns (SP) for F10 (see all 6)    About this scheme

    ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7a · 7b ^ 8a · 8b · 8c ^ 9a · 9b · 9c
    SP1:                          -                 -                 -                                       
    SP2:                          -                 -     -           -                                       
    SP3:                          -                 -                                                         
    SP4:                                            -                 -                 -                     
    SP5:                                                              -                                       


    ECgene alternative splicing isoforms for F10

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    F10 expression in normal human tissues (normalized intensities)      F10 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CCCCGGAGGT
    F10 Expression
    About this image


    F10 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/14 selected tissues (see all 14) fully expand
     
     Blood (Hematopoietic System)    fully expand to see all 4 entries
             Monocytes Peripheral Blood
             umbilical cord reticulocytes   
     
     Fibroblast
             Human Gingival Fibroblasts (HGF)   
     
     Dermis (Uncategorized)    fully expand to see all 3 entries
             Human Dermal Fibroblasts-adult (HDF-a)   
     
     Uncategorized (Uncategorized)    fully expand to see all 2 entries
             PureStem Progenitor W10
     
     Skeletal Muscle (Muscoskeletal System)    fully expand to see all 2 entries
             Muscle Progenitor Cells Mandibular Arch Muscles

    See F10 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for F10

    SOURCE GeneReport for Unigene cluster: Hs.361463

    UniProtKB/Swiss-Prot: FA10_HUMAN, P00742
    Tissue specificity: Plasma; synthesized in the liver

        SABiosciences Expression via Pathway-Focused PCR Array including F10: 
              Hypoxia Signaling Pathway in human mouse rat

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for F10 gene from 6/15 species (see all 15)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia F101 , 5 coagulation factor X1, 5 77.97(n)1
    77.54(a)1
      8 (5.73 cM)5
    140581  NM_007972.41  NP_031998.31 
     130373085 
    chicken
    (Gallus gallus)
    Aves F101 coagulation factor X 59.8(n)
    57.3(a)
      395876  NM_205022.1  NP_990353.1 
    lizard
    (Anolis carolinensis)
    Reptilia F106
    coagulation factor X
    48(a)
    1 ↔ 1
    3(105945146-105965778)
    African clawed frog
    (Xenopus laevis)
    Amphibia MGC684542 hypothetical protein MGC68454 74.97(n)    BC060330.1 
    zebrafish
    (Danio rerio)
    Actinopterygii f102 coagulation factor X 74.88(n)   282670  BC056804.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG118361 , 3 serine-type endopeptidase3
    CG118361
    39(a)3
    48.92(n)1
    39.83(a)1
      96B203
    430071  NM_001170247.31  NP_001163718.31 


    ENSEMBL Gene Tree for F10 (if available)
    TreeFam Gene Tree for F10 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for F10 gene
    PAMR12  PROZ2  C1S2  C1R2  C1RL2  F92  MASP12  F22  
    HPR2  F72  PROC2  HP2  MASP22  
    16 SIMAP similar genes for F10 using alignment to 6 protein entries:     FA10_HUMAN (see all proteins):
    PRRG1    PROS1    PRRG3    PROC1    F9    KLK4
    F9 p22    PRSS1    factor IX F9    F2    PRRG2    PRSS2
    TRY8    F7    PROC    KLK9

    F10 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/806 SNPs in F10 are shown (see all 806)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 13 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0654494
    Factor X deficiency (FA10D)4--see VAR_0654492 C R mis40--------
    VAR_0654354
    Factor X deficiency (FA10D)4--see VAR_0654352 C Y mis40--------
    VAR_0654424
    Factor X deficiency (FA10D)4--see VAR_0654422 E K mis40--------
    VAR_0654364
    Factor X deficiency (FA10D)4--see VAR_0654362 C Y mis40--------
    VAR_0654514
    Factor X deficiency (FA10D)4--see VAR_0654512 G R mis40--------
    VAR_0654454
    Factor X deficiency (FA10D)4--see VAR_0654452 R C mis40--------
    VAR_0654374
    Factor X deficiency (FA10D)4--see VAR_0654372 G R mis40--------
    VAR_0654414
    Factor X deficiency (FA10D)4--see VAR_0654412 V M mis40--------
    VAR_0654384
    Factor X deficiency (FA10D)4--see VAR_0654382 E K mis40--------
    VAR_0654284
    Factor X deficiency (FA10D)4--see VAR_0654282 E G mis40--------

    HapMap Linkage Disequilibrium report for F10 (113777113 - 113803843 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 10/16 variations for F10 (see all 16):    About this table     
    Variant IDTypeSubtypePubMed ID
    esv1499407CNV Deletion17803354
    esv2678487CNV Deletion23128226
    esv2748261CNV Deletion23290073
    nsv901049CNV Loss21882294
    nsv901039CNV Loss21882294
    dgv1800n71CNV Loss21882294
    nsv832724CNV Loss17160897
    dgv1797n71CNV Loss21882294
    dgv1798n71CNV Loss21882294
    nsv901065CNV Loss21882294


    Human Gene Mutation Database (HGMD): F10
    SABiosciences Cancer Mutation PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 613872    OMIM disorders: --

    UniProtKB/Swiss-Prot: FA10_HUMAN, P00742
  • Factor X deficiency (FA10D) [MIM:227600]: A hemorrhagic disease with variable presentation. Affected
    individuals can manifest prolonged nasal and mucosal hemorrhage, menorrhagia, hematuria, and occasionally
    hemarthrosis. Some patients do not have clinical bleeding diathesis. Note=The disease is caused by mutations
    affecting the gene represented in this entry

  • 20/93 diseases for F10 (see all 93):    About MalaCards
    factor x deficiency    hemarthrosis    antithrombin iii deficiency    quebec platelet disorder
    heparin-induced thrombocytopenia    carotid artery thrombosis    blood clots    venous thromboembolism
    scott syndrome    hemophilia    acquired hemophilia    hemophilia b
    al amyloidosis    deep vein thrombosis    warfarin sensitivity    factor vii deficiency
    thrombasthenia    glanzmann's thrombasthenia    dysfibrinogenemia    thromboembolism

    4 diseases from the University of Copenhagen DISEASES database for F10:
    Carney complex     Pulmonary embolism     Factor X deficiency     Disseminated intravascular coagulation

    F10 for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:  
    The International Symposium on Pneumococci and Pneumococcal Diseases (ISPPD) 9 - 13 March 2014
    Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015

    10/85 Novoseek inferred disease relationships for F10 gene (see all 85)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    factor x deficiency 81 3 9799000 (1), 8449937 (1), 15569527 (1)
    thromboembolism 80.6 54 16409461 (2), 19485937 (2), 16241946 (2), 14650860 (2) (see all 44)
    scott syndrome 76.1 5 1730083 (2), 9054648 (1), 19408196 (1), 11421293 (1)
    thrombosis 76 71 10604970 (2), 11554940 (2), 12829728 (2), 15338955 (2) (see all 54)
    deep vein thrombosis 71.1 8 15091002 (1), 15554723 (1), 8029801 (1), 12750119 (1) (see all 8)
    arterial thrombosis 69.2 17 10813384 (1), 11177336 (1), 11342132 (1), 17729190 (1) (see all 14)
    bleeding 67.9 53 11554940 (2), 19598069 (2), 12829728 (2), 14633255 (2) (see all 44)
    venous thrombosis 62.8 25 11434677 (3), 9241747 (2), 9336303 (1), 10813384 (1) (see all 14)
    coagulopathy 62.1 15 11554940 (2), 19598069 (2), 14995986 (1), 12161341 (1) (see all 11)
    hemophilia a 60.9 3 2130929 (1), 14717973 (1), 16409469 (1)

    Genatlas disease: F10
    bleeding diathesis (FX deficiency)

    Genetic Association Database (GAD): F10
    Human Genome Epidemiology (HuGE) Navigator: F10 (17 documents)

    Export disorders for F10 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for F10 gene, integrated from 9 sources (see all 1582):
    (articles sorted by number of sources associating them with F10)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Characterization of a homozygous Gly11Val mutation in the Gla domain of coagulation factor X. (PubMed id 19135706)1, 2, 9 Chafa O....Lebonniec B.F. (2009)
    2. Activation-dependent exposure of the inter-EGF sequence Leu83-Leu88 in factor Xa mediates ligand binding to effector cell protease receptor-1. (PubMed id 9079657)1, 7, 9 Ambrosini G....Altieri D.C. (1997)
    3. Monitoring Unfractionated Heparin (UFH) therapy: which Anti-Factor Xa assay is appropriate? (PubMed id 17118432)1, 7, 9 Ignjatovic V....Monagle P. (2007)
    4. Analysis of the novel factor X gene mutation Glu51Lys in two families with factor X-Riyadh anomaly. (PubMed id 17393015)1, 2, 9 Al-Hilali A....Herrmann F.H. (2007)
    5. Structural basis for chemical inhibition of human blood coagulation factor Xa. (PubMed id 9618463)1, 2, 9 Kamata K.... Kim S.H. (1998)
    6. Structure of human des(1-45) factor Xa at 2.2-A resolution. (PubMed id 8355279)1, 2, 9 Padmanabhan K.... Kisiel W. (1993)
    7. Cloning and expression in COS-1 cells of a full-length cDNA encoding human coagulation factor X. (PubMed id 1902434)1, 2, 9 Messier T.L.... Church W.R. (1991)
    8. Basis for the specificity and activation of the serpi n protein Z-dependent proteinase inhibitor (ZPI) as an inhibitor of membrane-as sociated factor Xa. (PubMed id 20427285)1, 2 Huang X....Gettins P.G. (2010)
    9. Maternal and fetal genetic associations of PTGER3 and PON1 with preterm birth. (PubMed id 20140262)1, 4 Ryckman K.K....Jacobsson B. (2010)
    10. Variation at the NFATC2 locus increases the risk of t hiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipr il and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1, 4 Bailey S.D....Anand S. (2010)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 2159 HGNC: 3528 AceView: F10 Ensembl:ENSG00000126218 euGenes: HUgn2159
    ECgene: F10 Kegg: 2159 H-InvDB: F10

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for F10 Pharmacogenomics, SNPs, Pathways
    Wikipedia http://en.wikipedia.org/wiki/Factor_X
    SeattleSNPshttp://pga.gs.washington.edu/data/f10/

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for F10 gene:
    Search GeneIP for patents involving F10

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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