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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

F10 Gene

protein-coding GIFtS: 70
GCID: GC13P113777

coagulation factor X

Explore 104 diseases affiliated with
F10 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Coagulation Factor X¹ ²		Factor Xa²
Stuart-Prower Factor² ³		Prothrombinase¹
EC 3.4.21.6³ ⁸		Stuart Factor³
FX²		EC 3.4.21⁸
FXA²

External Ids:	HGNC: 3528¹	Entrez Gene: 2159²	Ensembl: ENSG00000126218⁷	OMIM: 613872⁵	UniProtKB: P00742³

Export aliases for F10 gene to outside databases

Previous GC identifers: GC13P112387 GC13P108414 GC13P112863 GC13P111725 GC13P112825 GC13P094215

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for F10:

This gene encodes the vitamin K-dependent coagulation factor X of the blood coagulation cascade. This factor undergoes

multiple processing steps before its preproprotein is converted to a mature two-chain form by the excision of the

tripeptide RKR. Two chains of the factor are held together by 1 or more disulfide bonds; the light chain contains 2

EGF-like domains, while the heavy chain contains the catalytic domain which is structurally homologous to those of the

other hemostatic serine proteases. The mature factor is activated by the cleavage of the activation peptide by factor

IXa (in the intrisic pathway), or by factor VIIa (in the extrinsic pathway). The activated factor then converts

prothrombin to thrombin in the presence of factor Va, Ca+2, and phospholipid during blood clotting. Mutations of this

gene result in factor X deficiency, a hemorrhagic condition of variable severity. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: FA10_HUMAN, P00742

Function: Factor Xa is a vitamin K-dependent glycoprotein that converts prothrombin to thrombin in the presence of

factor Va, calcium and phospholipid during blood clotting

Gene Wiki entry for F10 (Factor X)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000013.10 NC_018924.1 NT_027140.6

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the F10 gene promoter:
E2F-4 c-Fos E2F-1 E2F AP-1 ATF-2 c-Jun
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: F10 promoter sequence

Search SABiosciences Chromatin IP Primers for F10

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat F10

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 13q34 Ensembl cytogenetic band: 13q34 HGNC cytogenetic band: 13q34

F10 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
F10 gene location

GeneLoc information about chromosome 13 GeneLoc Exon Structure

GeneLoc location for GC13P113777: view genomic region (about GC identifiers)

Start:	113,777,113 bp from pter	End:	113,803,843 bp from pter
Size:	26,731 bases	Orientation:	plus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: FA10_HUMAN, P00742 (See protein sequence)

Recommended Name: Coagulation factor X precursor

Size: 488 amino acids; 54732 Da

Subunit: The two chains are formed from a single-chain precursor by the excision of two Arg residues and are held

together by 1 or more disulfide bonds. Forms a heterodimer with SERPINA5

Subcellular location: Secreted

6/125 PDB 3D structures from and Proteopedia for F10 (see all 125):

1C5M (3D)

1EZQ (3D)

1F0R (3D)

1F0S (3D)

1FAX (3D)

1FJS (3D)

Secondary accessions: Q14340

Explore the universe of human proteins at neXtProt for F10: NX_P00742

Post-translational modifications:

The vitamin K-dependent, enzymatic carboxylation of some glutamate residues allows the modified protein to bind calcium¹

N- and O-glycosylated. O-glycosylated with core 1 or possibly core 8 glycans¹

The activation peptide is cleaved by factor IXa (in the intrinsic pathway), or by factor VIIa (in the extrinsic

pathway)¹

The iron and 2-oxoglutarate dependent 3-hydroxylation of aspartate and asparagine is (R) stereospecific within EGF

domains¹

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_P00742

4/13 DME Specific Peptides for F10 (P00742) (see all 13)

FCGGTIL

GECPWQA

SWGEGCA

TGIVSWG

F10 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins: NP_000495.1

ENSEMBL proteins:

ENSP00000387092 ENSP00000364701 ENSP00000364709 ENSP00000386320

Reactome Protein details: P00742
Human Recombinant Protein Products:

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	Uscn Proteins for F10

Gene Ontology (GO): 5/7 cellular component terms (GO ID links to tree view) (see all 7): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005576	extracellular region	TAS	--
GO:0005624	membrane fraction	--	--
GO:0005788	endoplasmic reticulum lumen	TAS	--
GO:0005792	microsome	--	--
GO:0005796	Golgi lumen	TAS	--

F10 for ontologies About GeneDecksing

F10 Antibody Products:

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	Uscn ELISAs and CLIAs for F10

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

F10 for domains About GeneDecksing

5/12 InterPro domains/families (see all 12):

IPR017857 Coagulation_fac_subgr_Gla_dom

IPR001314 Peptidase_S1A

IPR000742 EG-like_dom

IPR000152 EGF-type_Asp/Asn_hydroxyl_site

IPR018097 EGF_Ca-bd_CS

Graphical View of Domain Structure for InterPro Entry P00742

ProtoNet protein and cluster: P00742

5/7 Blocks protein families (see all 7):

IPB000152 Aspartic acid and asparagine hydroxylation site

IPB000294 Vitamin K-dependent carboxylation/gamma-carboxyglutamic (GLA) domain

IPB001254 Serine protease

IPB001314 Chymotrypsin serine protease family (S1) signature

IPB001438 Type II EGF-like signature

UniProtKB/Swiss-Prot: FA10_HUMAN, P00742

Similarity: Belongs to the peptidase S1 family

Similarity: Contains 2 EGF-like domains

Similarity: Contains 1 Gla (gamma-carboxy-glutamate) domain

Similarity: Contains 1 peptidase S1 domain

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: FA10_HUMAN, P00742

Function: Factor Xa is a vitamin K-dependent glycoprotein that converts prothrombin to thrombin in the presence of

factor Va, calcium and phospholipid during blood clotting

Catalytic activity: Selective cleavage of Arg- -Thr and then Arg- -Ile bonds in prothrombin to form thrombin

Enzyme regulation: Inhibited by SERPINA5 and SERPINA10

Genatlas biochemistry entry for F10:

coagulation factor X (Stuart Prower),vitamin K-dependent

Enzyme Numbers (IUBMB): EC 3.4.21.6¹ ² EC 3.4.21²

miRNA Products:		Browse 3'-UTR reporter clones for miRNA target validation Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat F10
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Gene Editing
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In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for F10

Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0004252	serine-type endopeptidase activity	TAS	--
GO:0005509	calcium ion binding	IEA	--
GO:0005515	protein binding	IPI	6323392
GO:0005543	phospholipid binding	IDA	17469850

F10 for ontologies           About GeneDecksing

Animal Models:
     Mouse knock-outs for F10: F10^tm1Ccmt F10^tm1Edr
     4 MGI mutant phenotypes (inferred from 3 alleles) (MGI details for F10):

cardiovascular system

homeostasis/metabolism

mortality/aging

reproductive system

F10 for phenotypes About GeneDecksing

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways - 5/8 super-pathways (see all 8) About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Gamma-carboxylation, transport, and amino-terminal cleavage of proteins

Gamma-carboxylation, transport, and amino-terminal cleavage of proteins	1.00	Transport of gamma-carboxylated protein precursors from the endoplasmic reticulum to the Golgi apparatus	0.73
Removal of aminoterminal propeptides from gamma-carboxylated proteins	0.82	Warfarin Pathway, Pharmacodynamics	0.67
Gamma-carboxylation of protein precursors	0.82	Extrinsic Pathway	0.23

Formation of Fibrin Clot (Clotting Cascade)

	Formation of Fibrin Clot (Clotting Cascade)	1.00			Blood Coagulation Signaling Pathways	0.51
	Intrinsic Pathway	0.59			Blood Clotting Cascade	0.36

Blood Coagulation Cascade

Blood Coagulation Cascade

1.00

Intrinsic Prothrombin Activation Pathway

0.96

Complement and coagulation cascades

Complement and coagulation cascades

1.00

Complement and Coagulation Cascades

0.72

Common Pathway

Common Pathway

1.00

Extrinsic Prothrombin Activation Pathway

0.69

Pathway sources
See GeneCards unified pathways
Show all pathways

1 R&D Systems Pathway for F10

Blood Coagulation Signaling Pathways

3 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for F10

	Extrinsic Prothrombin Activation Pathway
	Blood Coagulation Cascade
	Intrinsic Prothrombin Activation Pathway

2 BioSystems Pathways for F10

	Blood Clotting Cascade
	Complement and Coagulation Cascades

5/12 Reactome Pathways for F10 (see all 12)

	Hemostasis
	Extrinsic Pathway
	Intrinsic Pathway
	Removal of aminoterminal propeptides from gamma-carboxylated proteins
	Common Pathway

1 PharmGKB Pathway for F10

Warfarin Pathway, Pharmacodynamics

1 Kegg Pathway (Kegg details for F10):

Complement and coagulation cascades

F10 for pathways About GeneDecksing

Interactions:

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for F10

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

5/35 Interacting proteins for F10 (P00742^{2, 3} ENSP00000364709⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 35)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
MGST3	O14880³, ENSP00000356859⁴	I2D: score=3 STRING: ENSP00000356859
F5	P12259³, ENSP00000356771⁴	I2D: score=2 STRING: ENSP00000356771
F7	P08709³, ENSP00000364731⁴	I2D: score=2 STRING: ENSP00000364731
F8	P00451³, ENSP00000353393⁴	I2D: score=2 STRING: ENSP00000353393
HIST1H1C	P16403³, ENSP00000339566⁴	I2D: score=2 STRING: ENSP00000339566

About this table

Gene Ontology (GO): 5/9 biological process terms (GO ID links to tree view) (see all 9): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006508	proteolysis	TAS	--
GO:0007596	blood coagulation	TAS	--
GO:0007597	blood coagulation, intrinsic pathway	TAS	--
GO:0007598	blood coagulation, extrinsic pathway	TAS	--
GO:0017187	peptidyl-glutamic acid carboxylation	TAS	--

F10 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

F10 for compounds About GeneDecksing

EMD Millipore small molecules for F10:
Small Molecule - inhibitor

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for F10

2 HMDB Compounds for F10 About this table

Compound	Synonyms	CAS #	PubMed Ids
Calcium	Ca (see all 2)	7440-70-2	--
Menadione	Vitamin K3: 1,4-Dihydro-1,4-dioxo-2-methylnaphthalene (see all 49)	58-27-5	--

10/38 DrugBank Compounds for F10 (see all 38) About this table

Compound	Synonyms	CAS #	Type	Actions	PubMed Ids
Coagulation Factor IX	Christmas factor (see all 4)	9001-28-9	target	activator	1391956 659613 9079657 11752352 8083242 10919405 10933803
Antihemophilic Factor	AHF (see all 3)	--	target	activator	14285227 6436416 236567 11891806 13801371
Coagulation factor VIIa	Coagulation factor VII precursor (see all 5)	9001-25-6	target	--	5969560 13713641 14227143 13621053 13801371
Enoxaparin	LMWH (see all 2)	9005-49-6	target	inhibitor	17567541 17474542 16187968 17509040 15675440
Heparin	Alpha-Heparin (see all 8)	9005-49-6	target	inhibitor	17004727 17118432 3155697 11369259
Menadione	2-Methyl-1,4-Naphthalenedione (see all 7)	58-27-5	target	activator	17139284 17016423
Rivaroxaban	--	366789-02-8	target	antagonist	20135071 20424181
(2R)-2-(5-CHLORO-2-THIENYL)-N-{(3S)-1-[(1S)-1-METHYL-2-MORPHOLIN-4-YL-2-OXOETHYL]-2-OXOPYRROLIDIN-3-YL}PROPENE-1-SULFONAMIDE	--	--	target	--	10592235
(2R,4R)-N~1~-(4-CHLOROPHENYL)-N~2~-[2-FLUORO-4-(2-OXOPYRIDIN-1(2H)-YL)PHENYL]-4-METHOXYPYRROLIDINE-1,2-DICARBOXAMIDE	--	--	target	--	10592235
1-[[(1E)-2-(4-CHLOROPHENYL)ETHENYL]SULFONYL]-4-[[1-(4-PYRIDINYL)-4-PIPERIDINYL]METHYL]PIPERAZINE	--	--	target	--	10592235

10/115 Novoseek chemical compound relationships for F10 gene (see all 115) About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
rivaroxaban	94.4	125	17938768 (3), 18307374 (3), 20139357 (3), 17595891 (3) (see all 77)
fondaparinux	94.3	179	12871328 (3), 15744699 (3), 15171960 (2), 12501872 (2) (see all 99)
apixaban	91.7	42	19851712 (5), 18315548 (3), 17868430 (2), 18393142 (1) (see all 29)
heparin	88.8	634	12871328 (6), 11009624 (5), 9642241 (5), 19967150 (5) (see all 99)
heparin pentasaccharide	88.6	11	12353073 (2), 11854268 (1), 14532267 (1), 12871328 (1) (see all 8)
dabigatran etexilate	86.4	16	19601856 (1), 19550318 (1), 18473863 (1), 19803538 (1) (see all 13)
otamixaban	83	12	17139573 (3), 17178269 (2), 16493482 (2), 19717184 (1) (see all 8)
hirudin	82.4	65	12883328 (3), 7740455 (3), 8218854 (2), 2096492 (2) (see all 42)
antistasin	82.1	23	7740449 (2), 9804761 (2), 8218854 (2), 1990979 (2) (see all 12)
gamma-carboxyglutamic acid	81.4	47	8226763 (4), 17387172 (3), 9780208 (2), 8355279 (1) (see all 19)

Search CenterWatch for drugs/clinical trials and news about F10 / FA10

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for F10 gene:

NM_000504.3

Unigene Cluster for F10:

Coagulation factor X

Hs.361463 [show with all ESTs]

Unigene Representative Sequence: BC040125

7 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000409306 ENST00000375551(uc001vsy.3) ENST00000375559(uc001vsx.3)

ENST00000477269 ENST00000483537 ENST00000410083(uc010agq.1) ENST00000498455

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		GenScript: all cDNA clones in your preferred vector: F10 (NM_014206)
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		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat F10
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat F10

Additional cDNA sequence:

AK310772.1 AK310775.1 AK313798.1 BC040125.1 BC046125.1 K01886.1 K03194.1 M22613.1

M57285.1

8 DOTS entries:

DT.313355 DT.97856616 DT.100676340 DT.97861708 DT.120640635 DT.120780844 DT.97781688 DT.121305757

24/72 AceView cDNA sequences (see all 72):

CR607773 CD518821 BQ018853 CD014138 CA444781 CB162539 CB158437 BU846186

BQ027447 CR623031 BM709916 BP339855 NM_000504 M22613 BC046125 M57285

BU849949 BC040125 K01886 CD013940 CR603372 CD676150 BM987312 AL576464

GeneLoc Exon Structure

5/6 Alternative Splicing Database (ASD) splice patterns (SP) for F10 (see all 6) About this scheme

ExUns:	1a	·	1b	·	1c	^	2	^	3	^	4	^	5	^	6a	·	6b	^	7a	·	7b	^	8a	·	8b	·	8c	^	9a	·	9b	·	9c
SP1:									-						-						-
SP2:									-						-		-				-
SP3:									-						-
SP4:															-						-						-
SP5:																					-

ECgene alternative splicing isoforms for F10

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

F10 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: CCCCGGAGGT

About this image

F10 expression in embryonic tissues and stem cells

Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

3 LifeMap In Vivo Development Anatomical Compartments/Cells

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Heart

Cardiac Crescent

Cardiac Crescent Cells

Myocardium

Ovary

Definitive Hematopoietic Stem Cells

Blood

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

Stem Cell Differentiation: 4 LifeMap Cells

Name

Category

PureStem™ progenitor EN7 (Embryonic Progenitor Cell)

PureStem™ progenitor W10 (Embryonic Progenitor Cell)

Definitive endoderm-like cells (Generation and expan...)

Endoderm progenitor-like cells (Generation and expan...)

See F10 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for F10

SOURCE GeneReport for Unigene cluster: Hs.361463

UniProtKB/Swiss-Prot: FA10_HUMAN, P00742

Tissue specificity: Plasma; synthesized in the liver

SABiosciences Expression via Pathway-Focused PCR Array including F10:

Hypoxia Signaling Pathway in human mouse rat

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(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of animals.

Orthologs for F10 gene from 5/16 species (see all 16) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
chicken (Gallus gallus)	Aves	F10¹	coagulation factor X	59.8(n) 57.3(a)		395876 NM_205022.1 NP_990353.1
lizard (Anolis carolinensis)	Reptilia	F10⁶	--	46(a)	1 ↔ 1	3(105959705-105966831)
African clawed frog (Xenopus laevis)	Amphibia	MGC68454²	hypothetical protein MGC68454	74.97(n)		BC060330.1
zebrafish (Danio rerio)	Actinopterygii	f10²	coagulation factor X	74.88(n)		282670 BC056804.1
fruit fly (Drosophila melanogaster)	Insecta	CG11836^{1 , 3}	serine-type endopeptidase³ CG11836¹	39(a)³ 48.92(n)¹ 39.83(a)¹		96B20³ 43007¹ NM_001170247.3¹ NP_001163718.3¹

ENSEMBL Gene Tree for F10 (if available)
TreeFam Gene Tree for F10 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for F10 gene

PROZ² PAMR1² C1S² C1R² C1RL² F9² MASP1² F2²

HPR² HP² PROC² F7² MASP2²

15 SIMAP similar genes for F10 using alignment to 6 protein entries: FA10_HUMAN (see all proteins):

PRRG1 PROS1 PRRG3 PROC1 F9 KLK4

F9 p22 PRSS1 factor IX F9 F2 PRSS2 TRY8

F7 PROC KLK9

F10 for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 13 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs61753266^1,2	C,F,	pathogenic	94233671(+)	`GCCACG/AAGGAA`	2	/K /E	mis¹		1		NA	4552
rs104894392^1,2	C	pathogenic	94241845(+)	`TCGGGC/TGCACC`	2	R C	mis¹		0	--	--	--	--
rs79275668^1,2	C,	--	94214234(+)	`CCAGAA/CCCACA`	1	--	us2k¹		0	--	--	--	--
rs3093268^1,2	C,F,	--	94214362(+)	`CAGAGG/CCTTCG`	1	--	us2k¹ tfbs³		12		NS NA WA	2438
rs3211708^1,2	H	--	94214377(+)	`AGGGCC/TTGGGC`	1	--	us2k¹		6		NS EA	494
rs3212990^1,2	C,F,H,	--	94214580(+)	`GCCATG/AAGCAT`	1	--	us2k¹		10		NS EA NA	676
rs79793099^1,2	C,F,	--	94214788(+)	`CAGTCG/AGGTGG`	1	--	us2k¹		1		WA	118
rs3211710^1,2	H	--	94214881(+)	`CAGGGC/TGACCC`	1	--	us2k¹		6		NS EA	514
rs474671^1,2	C,F,	--	94214923(+)	`AGTGCT/CGTGGG`	1	--	us2k¹		21		EA NA NS WA CSA	1307
rs3211712^1,2	C,F,H,	--	94215061(+)	`CACAGC/GCATTG`	1	--	us2k¹		7		NS EA NA	358

HapMap Linkage Disequilibrium report for F10 (113777113 - 113803843 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 7 variations for F10
5 CNVs: 76521 9723 4819 87067 87068
2 Indels: 87069 25168
Human Gene Mutation Database (HGMD): F10

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

F10 for disorders About GeneDecksing

OMIM gene information: 613872 OMIM disorders: --

UniProtKB/Swiss-Prot: FA10_HUMAN, P00742

Defects in F10 are the cause of factor X deficiency (FA10D) [MIM:227600]. A hemorrhagic disease with variable

presentation. Affected individuals can manifest prolonged nasal and mucosal hemorrhage, menorrhagia, hematuria, and

occasionally hemarthrosis. Some patients do not have clinical bleeding diathesis

20/104 diseases for F10 (see all 104): About MalaCards

factor x deficiency vitamin k-dependent clotting factors disseminated intravascular coagulation antithrombin iii deficiency

quebec platelet disorder factor vii deficiency heparin-induced thrombocytopenia deep vein thrombosis

glanzmann's thrombasthenia paroxysmal nocturnal hemoglobinuria dysprothrombinemia west nile virus

beta thalassemia hemophilia intermittent claudication carotid artery thrombosis

hemarthrosis pre-eclampsia myocardial infarction atrial fibrillation

4 diseases from the University of Copenhagen DISEASES database for F10:

Carney complex Pulmonary embolism Factor X deficiency Disseminated intravascular coagulation

10/85 Novoseek disease relationships for F10 gene (see all 85) About this table

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
factor x deficiency	81	3	9799000 (1), 8449937 (1), 15569527 (1)
thromboembolism	80.6	54	16409461 (2), 19485937 (2), 16241946 (2), 14650860 (2) (see all 44)
scott syndrome	76.1	5	1730083 (2), 9054648 (1), 19408196 (1), 11421293 (1)
thrombosis	76	71	10604970 (2), 11554940 (2), 12829728 (2), 15338955 (2) (see all 54)
deep vein thrombosis	71.1	8	15091002 (1), 15554723 (1), 8029801 (1), 12750119 (1) (see all 8)
arterial thrombosis	69.2	17	10813384 (1), 11177336 (1), 11342132 (1), 17729190 (1) (see all 14)
bleeding	67.9	53	11554940 (2), 19598069 (2), 12829728 (2), 14633255 (2) (see all 44)
venous thrombosis	62.8	25	11434677 (3), 9241747 (2), 9336303 (1), 10813384 (1) (see all 14)
coagulopathy	62.1	15	11554940 (2), 19598069 (2), 14995986 (1), 12161341 (1) (see all 11)
hemophilia a	60.9	3	2130929 (1), 14717973 (1), 16409469 (1)

Genatlas disease: F10

bleeding diathesis (FX deficiency)

Human Genome Epidemiology (HuGE) Navigator: F10 (17 documents)

Export disorders for F10 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for F10 gene, integrated from 9 sources (see all 1571):
(articles sorted by number of sources associating them with F10)

Utopia: connect your pdf to the dynamic
world of online information

Characterization of a homozygous Gly11Val mutation in the Gla domain of coagulation factor X. (PubMed id 19135706)^{1, 2, 9} Chafa O....Lebonniec B.F. (2009)
Activation-dependent exposure of the inter-EGF sequence Leu83-Leu88 in factor Xa mediates ligand binding to effector cell protease receptor-1. (PubMed id 9079657)^{1, 7, 9} Ambrosini G....Altieri D.C. (1997)
Monitoring Unfractionated Heparin (UFH) therapy: which Anti-Factor Xa assay is appropriate? (PubMed id 17118432)^{1, 7, 9} Ignjatovic V....Monagle P. (2007)
Analysis of the novel factor X gene mutation Glu51Lys in two families with factor X-Riyadh anomaly. (PubMed id 17393015)^{1, 2, 9} Al-Hilali A....Herrmann F.H. (2007)
Structural basis for chemical inhibition of human blood coagulation factor Xa. (PubMed id 9618463)^{1, 2, 9} Kamata K.... Kim S.H. (1998)
Structure of human des(1-45) factor Xa at 2.2-A resolution. (PubMed id 8355279)^{1, 2, 9} Padmanabhan K.... Kisiel W. (1993)
Cloning and expression in COS-1 cells of a full-length cDNA encoding human coagulation factor X. (PubMed id 1902434)^{1, 2, 9} Messier T.L.... Church W.R. (1991)
Basis for the specificity and activation of the serpi n protein Z-dependent proteinase inhibitor (ZPI) as an inhibitor of membrane-as sociated factor Xa. (PubMed id 20427285)^{1, 2} Huang X....Gettins P.G. (2010)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
Molecular analysis of the genotype-phenotype relationship in factor X deficiency. (PubMed id 10746568)^{1, 2} Millar D.S....Cooper D.N. (2000)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Disorders
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 2159	HGNC: 3528	AceView: F10	Ensembl:ENSG00000126218	euGenes: HUgn2159
ECgene: F10	Kegg: 2159	H-InvDB: F10

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for F10	Pharmacogenomics, SNPs, Pathways
Wikipedia	http://en.wikipedia.org/wiki/Factor_X
SeattleSNPs	http://pga.gs.washington.edu/data/f10/

Intellectual Property for F10 gene
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Patent Information for F10 gene:
Search GeneIP for patents involving F10

GeneCards and IP:
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coagulation factor X

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F10 Gene

coagulation factor X

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