EPB41L4B Gene
protein-coding GIFtS: 47
GCID: GC09M111934
|
|
erythrocyte membrane protein band 4.1 like 4B
| |
Aliases
for EPB41L4B gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Erythrocyte Membrane Protein Band 4.1 Like 4B1 2 | | EHM21 2 3 5 | | FERM-Containing Protein CG12 3 | | CG12 | | Band 4.1-Like Protein 4B2 | | Protein EHM23 |
Export aliases for EPB41L4B gene to outside databasesPrevious GC identifers: GC09M103666 GC09M105391 GC09M107314 GC09M107286 GC09M109013 GC09M110974 GC09M081534 |
Summaries
for EPB41L4B gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
-- |
Genomic Views
for EPB41L4B gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000009.11 NC_018920.1 NT_008470.19
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the EPB41L4B gene promoter:
AhR FOXF2 Olf-1 POU6F1 (c2) Arnt POU2F1 FOXO4 POU2F1a LyF-1 Ik-1
Other transcription factors
Search SABiosciences Chromatin IP Primers for EPB41L4B
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat EPB41L4B |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 9q31-q32 Ensembl cytogenetic band: 9q31.3 HGNC cytogenetic band: 9q22.1-q22.3EPB41L4B Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 9 GeneLoc Exon Structure GeneLoc location for GC09M111934: view genomic region
(about GC identifiers)
Start:
|
111,934,254 bp from pter |
End:
|
112,083,244 bp from pter |
Size:
|
148,991 bases |
Orientation:
|
minus strand |
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Proteins
for EPB41L4B gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: E41LB_HUMAN, Q9H329 (See
protein sequence)Recommended Name: Band 4.1-like protein 4B Size: 900 amino acids; 99712 Da
Subcellular location: Cytoplasm, cytoskeleton (By similarity)
Sequence caution: Sequence=AAG43366.1; Type=Frameshift; Positions=19, 35, 870; Sequence=AAG43368.1; Type=Frameshift;Positions=19, 35;
Secondary accessions: Q5T4G5 Q5T4G6 Q9H328 Q9P2V3Alternative splicing: 2 isoforms: Q9H329-1 Q9H329-2 Explore the universe of human proteins at neXtProt for EPB41L4B: NX_Q9H329
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q9H329
EPB41L4B Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (2 alternative transcripts):
NP_060894.2 NP_061987.3
ENSEMBL proteins: ENSP00000363694 ENSP00000363685
Human Recombinant Protein Products:
Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view): About this table
EPB41L4B for ontologies About GeneDecksing
EPB41L4B Antibody Products:
Assay Products for EPB41L4B: |
Protein
Domains /
Families
for EPB41L4B gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
EPB41L4B for domains About GeneDecksing
5/11 InterPro domains/families (see all 11):Graphical View of Domain Structure for InterPro Entry Q9H329ProtoNet protein and cluster: Q9H329 2 Blocks protein families: IPB000299 Band 4.1 domain IPB000515 Binding-protein-dependent transport systems inner membrane component
UniProtKB/Swiss-Prot: E41LB_HUMAN, Q9H329Similarity: Contains 1 FERM domain |
Function
for EPB41L4B gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for EPB41L4B (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for EPB41L4B (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector (see all 2): EPB41L4B (NM_018424) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
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In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for EPB41L4B |
Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view): About this table
EPB41L4B for ontologies About GeneDecksing
3 GenomeRNAi human phenotypes for EPB41L4B:
|
Pathways & Interactions
for EPB41L4B gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for EPB41L4B
STRING Interaction
Network Preview (showing 4 interactants - click image to see more details)
4 Interacting proteins for EPB41L4B (ENSP000003636944) via UniProtKB, MINT, STRING, and/or I2DAbout this table
Gene Ontology (GO): 1 biological process term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0031032 | actomyosin structure organization |
IDA | -- |
EPB41L4B for ontologies About GeneDecksing
|
Drugs & Compounds
for EPB41L4B gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for EPB41L4B
Search CenterWatch for drugs/clinical trials and news about EPB41L4B / E41LB
|
Transcripts
for EPB41L4B gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for EPB41L4B gene (2 alternative transcripts): NM_018424.2 NM_019114.3 Unigene Cluster for EPB41L4B: Erythrocyte membrane protein band 4.1 like 4B Hs.591901 [show with all ESTs]Unigene Representative Sequence: AF1534162 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000374566(uc004bdz.1) ENST00000374557(uc004bea.3)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for EPB41L4B (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for EPB41L4B (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector (see all 2): EPB41L4B (NM_018424) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for EPB41L4B | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat EPB41L4B |
Additional cDNA sequence: AB032179.3 AB209187.1 AF153416.1 AF153418.1 AJ420414.1 AK000388.1 AL353947.1 7 DOTS entries: DT.100776706 DT.310414 DT.100776707 DT.75142288 DT.100652480 DT.121162433 DT.203968 24/131 AceView cDNA sequences (see all 131): CB158900 BX477781 AA468667 BF811165 AJ420414 AL599957 AA883634 CR618146 BU630309 AI476091 H94262 BG567685 AA448069 AK000388 AI004660 BU619322 AA385570 BM973130 AA902775 AI632258 CB215400 CK904512 AI922483 AI653142
GeneLoc Exon Structure
|
Expression
for EPB41L4B gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| EPB41L4B expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: --
About this image
See EPB41L4B Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for EPB41L4B
SOURCE GeneReport for Unigene cluster: Hs.591901
SABiosciences Custom PCR Arrays for EPB41L4B
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for EPB41L4B
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat EPB41L4B | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat EPB41L4B | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat EPB41L4B | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for EPB41L4B |
Orthologs
for EPB41L4B gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals.
Orthologs for EPB41L4B gene from 6/20 species (see all 20) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
chicken
(Gallus gallus) |
Aves |
EPB41L4B1 |
erythrocyte membrane protein band 4.1 like 4B |
74.83(n)
76.46(a) |
|
420962 XM_419046.3 XP_419046.3 |
lizard
(Anolis carolinensis) |
Reptilia |
EPB41L4B6 |
-- |
87(a) |
1 ↔ 1 |
6(57272732-57305047) |
tropical clawed frog
(Xenopus tropicalis) |
Amphibia |
Str.71842 |
Transcribed sequence with moderate similarity to protein more |
80.3(n) |
|
AL848030.2 |
zebrafish
(Danio rerio) |
Actinopterygii |
LOC1003326271 |
band 4.1-like protein 4B-like |
65.34(n)
67.04(a) |
|
100332627 XM_002664903.2 XP_002664949.1 |
fruit fly
(Drosophila melanogaster) |
Insecta |
yrt6 |
yurt |
28(a) |
1 → many |
3R(9254589-9260704) |
worm
(Caenorhabditis elegans) |
Secernentea |
frm-26 |
FERM domain (protein4.1-ezrin-radixin-moesin) fami... |
36(a) |
1 → many |
III(5976651-5982077) |
ENSEMBL Gene Tree for EPB41L4B (if available)
TreeFam Gene Tree for EPB41L4B (if available) |
Paralogs
for EPB41L4B gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for EPB41L4B gene
- EPB412 EPB41L52 FRMD32 EPB41L12 FARP12 FRMD52 MYLIP2 EPB41L32
- FRMD72 EPB41L4A2 FARP22 EPB41L22
13 SIMAP similar genes for EPB41L4B using alignment to 3 protein entries: E41LB_HUMAN (see all proteins):DKFZp761N1814 EPB41L5 PTPN4 EPB41L4A EPB41 EPB41L3
FRMD3 EPB41L2 FRMD5 FARP1 FARP2 FRMD7
PTPN3
EPB41L4B for paralogs About GeneDecksing
1 Pseudogenes.org Pseudogene for EPB41L4B
PGOHUM00000238805
|
Genomic Variants
for EPB41L4B gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 9 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for EPB41L4B (111934254 - 112083244 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for EPB41L4B
1 Indel: 70778 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing EPB41L4B |
|
Disorders
/ Diseases
for EPB41L4B gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
EPB41L4B for disorders About GeneDecksing
OMIM gene information: 610340
OMIM disorders: --
3  diseases for EPB41L4B: About MalaCardsdysautonomia fibrosarcoma melanoma
Human Genome Epidemiology (HuGE) Navigator: EPB41L4B (1 document)
Export disorders for EPB41L4B gene to outside databases
|
Publications
for EPB41L4B gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for EPB41L4B gene integrated from 9 sources:
(articles sorted by number of sources associating them with EPB41L4B) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Molecular cloning of a novel NF2/ERM/4.1 superfamily gene, Ehm2, that is expressed in high-metastatic K1735 murine melanoma cells. (PubMed id 10783258)1, 2, 3 Shimizu K....Yokota J. (2000)
- Cloning, mapping, and expression of a novel brain-specific transcript in the familial dysautonomia candidate region on chromosome 9q31. (PubMed id 10603000)1, 2 Chadwick B.P.... Slaugenhaupt S.A. (2000)
- A proteome-wide, quantitative survey of in vivo ubiqui tylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (2011)
- Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1 Rose J.E....Uhl G.R. (2010)
- Ubiquitin-mediated proteolysis of HuR by heat shock. (PubMed id 19322201)1 Abdelmohsen K....Gorospe M. (2009)
- Androgen control of cell proliferation and cytoskeletal reorganization in human fibrosarcoma cells: role of RhoB signaling. (PubMed id 14576147)1 Chauhan S....Miesfeld R.L. (2004)
- DNA sequence and analysis of human chromosome 9. (PubMed id 15164053)2 Humphray S.J.... Dunham I. (2004)
- Androgen regulation of the human FERM domain encoding gene EHM2 in a cell model of steroid-induced differentiation. (PubMed id 14521927)1 Chauhan S....Miesfeld R.L. (2003)
|
External Searches for EPB41L4B gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing EPB41L4B gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing EPB41L4B gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing EPB41L4B gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
|
About This Section
| Patent Information for EPB41L4B gene:
Search GeneIP for patents involving EPB41L4B
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for EPB41L4B gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat EPB41L4B | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing EPB41L4B | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat EPB41L4B | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat EPB41L4B | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat EPB41L4B | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat EPB41L4B |
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 | | | EPB41L4B Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for EPB41L4B |
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| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat EPB41L4B |
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