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Aliases for EZR Gene

Aliases for EZR Gene

  • Ezrin 2 3
  • VIL2 3 4 6
  • Villin 2 (Ezrin) 2 3
  • Cytovillin 2 2 3
  • Villin-2 3 4
  • CVL 3 6
  • P81 3 4
  • Epididymis Secretory Protein Li 105 3
  • Cytovillin 4
  • HEL-S-105 3
  • CVIL 3

External Ids for EZR Gene

Previous Symbols for EZR Gene

  • VIL2

Summaries for EZR Gene

Entrez Gene Summary for EZR Gene

  • The cytoplasmic peripheral membrane protein encoded by this gene functions as a protein-tyrosine kinase substrate in microvilli. As a member of the ERM protein family, this protein serves as an intermediate between the plasma membrane and the actin cytoskeleton. This protein plays a key role in cell surface structure adhesion, migration and organization, and it has been implicated in various human cancers. A pseudogene located on chromosome 3 has been identified for this gene. Alternatively spliced variants have also been described for this gene. [provided by RefSeq, Jul 2008]

GeneCards Summary for EZR Gene

EZR (Ezrin) is a Protein Coding gene. Diseases associated with EZR include pleomorphic malignant fibrous histiocytoma and chondroblastic osteosarcoma. Among its related pathways are Proteoglycans in cancer and Regulation of actin cytoskeleton. GO annotations related to this gene include actin filament binding and cell adhesion molecule binding. An important paralog of this gene is C1orf106.

UniProtKB/Swiss-Prot for EZR Gene

  • Probably involved in connections of major cytoskeletal structures to the plasma membrane. In epithelial cells, required for the formation of microvilli and membrane ruffles on the apical pole. Along with PLEKHG6, required for normal macropinocytosis.

Gene Wiki entry for EZR Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for EZR Gene

Genomics for EZR Gene

Genomic Location for EZR Gene

158,765,741 bp from pter
158,819,424 bp from pter
53,684 bases
Minus strand

Genomic View for EZR Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for EZR Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for EZR Gene

Regulatory Elements for EZR Gene

Transcription factor binding sites by QIAGEN in the EZR gene promoter:

Proteins for EZR Gene

  • Protein details for EZR Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein Accession:
    Secondary Accessions:
    • E1P5A8
    • P23714
    • Q4VX75
    • Q96CU8
    • Q9NSJ4

    Protein attributes for EZR Gene

    586 amino acids
    Molecular mass:
    69413 Da
    Quaternary structure:
    • Interacts with MPP5 and SLC9A3R2. Found in a complex with EZR, PODXL and SLC9A3R2 (By similarity). Interacts with MCC, PLEKHG6, PODXL, SCYL3/PACE1, SLC9A3R1 and TMEM8B. Interacts (when phosphorylated) with FES/FPS. Interacts with dimeric S100P, the interaction may be activating through unmasking of F-actin binding sites.
    • Sequence=AAA61278.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=CAB82418.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for EZR Gene

neXtProt entry for EZR Gene

Proteomics data for EZR Gene at MOPED

Post-translational modifications for EZR Gene

  • Phosphorylated by tyrosine-protein kinases. Phosphorylation by ROCK2 suppresses the head-to-tail association of the N-terminal and C-terminal halves resulting in an opened conformation which is capable of actin and membrane-binding (By similarity).
  • S-nitrosylation is induced by interferon-gamma and oxidatively-modified low-densitity lipoprotein (LDL(ox)) possibly implicating the iNOS-S100A8/9 transnitrosylase complex.
  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys35, Lys79, Lys83, Lys139, Lys237, Lys296, Lys344, and Lys450

Other Protein References for EZR Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for EZR Gene

Domains for EZR Gene

Gene Families for EZR Gene

  • AKAP :A-kinase anchor proteins

Suggested Antigen Peptide Sequences for EZR Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • The [IL]-x-C-x-x-[DE] motif is a proposed target motif for cysteine S-nitrosylation mediated by the iNOS-S100A8/A9 transnitrosylase complex.:
    • P15311
  • Contains 1 FERM domain.:
    • P15311
genes like me logo Genes that share domains with EZR: view

Function for EZR Gene

Molecular function for EZR Gene

UniProtKB/Swiss-Prot EnzymeRegulation: A head-to-tail association, of the N-terminal and C-terminal halves results in a closed conformation (inactive form) which is incapable of actin or membrane-binding.
UniProtKB/Swiss-Prot Function: Probably involved in connections of major cytoskeletal structures to the plasma membrane. In epithelial cells, required for the formation of microvilli and membrane ruffles on the apical pole. Along with PLEKHG6, required for normal macropinocytosis.

Gene Ontology (GO) - Molecular Function for EZR Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003779 actin binding --
GO:0005515 protein binding IPI 10793131
GO:0008092 cytoskeletal protein binding --
GO:0019904 protein domain specific binding IEA --
GO:0032403 protein complex binding --
genes like me logo Genes that share ontologies with EZR: view
genes like me logo Genes that share phenotypes with EZR: view

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for EZR Gene

Localization for EZR Gene

Subcellular locations from UniProtKB/Swiss-Prot for EZR Gene

Apical cell membrane; Peripheral membrane protein; Cytoplasmic side. Cell projection. Cell projection, microvillus membrane; Peripheral membrane protein; Cytoplasmic side. Cell projection, ruffle membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasm, cell cortex. Cytoplasm, cytoskeleton. Note=Localization to the apical membrane of parietal cells depends on the interaction with MPP5. Localizes to cell extensions and peripheral processes of astrocytes (By similarity). Microvillar peripheral membrane protein (cytoplasmic side). {ECO:0000250}.

Subcellular locations from

Jensen Localization Image for EZR Gene COMPARTMENTS Subcellular localization image for EZR gene
Compartment Confidence
cytoskeleton 5
cytosol 5
plasma membrane 5
nucleus 4
endosome 1
extracellular 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for EZR Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001726 ruffle IDA 9852149
GO:0001931 uropod IEA --
GO:0005615 extracellular space IDA 16502470
GO:0005622 intracellular --
GO:0005730 nucleolus IDA --
genes like me logo Genes that share ontologies with EZR: view

Pathways for EZR Gene

genes like me logo Genes that share pathways with EZR: view

Gene Ontology (GO) - Biological Process for EZR Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003376 sphingosine-1-phosphate signaling pathway IMP 23106337
GO:0007016 cytoskeletal anchoring at plasma membrane NAS 10793131
GO:0007159 leukocyte cell-cell adhesion IEP 12082081
GO:0007411 axon guidance TAS --
GO:0008360 regulation of cell shape IEA --
genes like me logo Genes that share ontologies with EZR: view

Compounds for EZR Gene

(47) Novoseek inferred chemical compound relationships for EZR Gene

Compound -log(P) Hits PubMed IDs
cytochalasin d 51.7 5
tyrosine 51 61
pip2 50.9 7
threonine 41.7 10
matrigel 35.7 7
genes like me logo Genes that share compounds with EZR: view

Transcripts for EZR Gene

Unigene Clusters for EZR Gene

Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for EZR Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b · 2c ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7a · 7b ^ 8a · 8b ^ 9 ^ 10 ^ 11a · 11b ^ 12a · 12b · 12c ^ 13a · 13b ^ 14a · 14b ^
SP1: - - - - - - -
SP2: - - - - - -
SP3: - -
SP4: - - - -
SP5: - - - -
SP6: - -
SP7: - -
SP9: -
SP10: -
SP12: - -

ExUns: 15a · 15b ^ 16 ^ 17 ^ 18 ^ 19
SP1: -
SP8: -
SP11: -

Relevant External Links for EZR Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for EZR Gene

mRNA expression in normal human tissues for EZR Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for EZR Gene

SOURCE GeneReport for Unigene cluster for EZR Gene Hs.487027

mRNA Expression by UniProt/SwissProt for EZR Gene

Tissue specificity: Expressed in cerebral cortex, basal ganglia, hippocampus, hypophysis, and optic nerve. Weakly expressed in brain stem and diencephalon. Stronger expression was detected in gray matter of frontal lobe compared to white matter (at protein level). Component of the microvilli of intestinal epithelial cells. Preferentially expressed in astrocytes of hippocampus, frontal cortex, thalamus, parahippocampal cortex, amygdala, insula, and corpus callosum. Not detected in neurons in most tissues studied.
genes like me logo Genes that share expressions with EZR: view

No data available for mRNA differential expression in normal tissues for EZR Gene

Orthologs for EZR Gene

This gene was present in the common ancestor of animals.

Orthologs for EZR Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia EZR 35
  • 99.72 (n)
  • 100 (a)
EZR 36
  • 100 (a)
(Bos Taurus)
Mammalia EZR 35
  • 88.58 (n)
  • 95.18 (a)
EZR 36
  • 95 (a)
(Canis familiaris)
Mammalia EZR 35
  • 89.87 (n)
  • 97.27 (a)
EZR 36
  • 97 (a)
(Mus musculus)
Mammalia Ezr 35
  • 88.62 (n)
  • 96.59 (a)
Ezr 16
Ezr 36
  • 97 (a)
(Monodelphis domestica)
Mammalia -- 36
  • 95 (a)
-- 36
  • 95 (a)
(Ornithorhynchus anatinus)
Mammalia EZR 36
  • 85 (a)
(Rattus norvegicus)
Mammalia Ezr 35
  • 88.85 (n)
  • 96.42 (a)
(Gallus gallus)
Aves EZR 35
  • 82.51 (n)
  • 90.26 (a)
EZR 36
  • 90 (a)
(Anolis carolinensis)
Reptilia EZR 36
  • 90 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia ezr 35
  • 75.32 (n)
  • 82.82 (a)
Str.11811 35
(Danio rerio)
Actinopterygii ezra 36
  • 75 (a)
ezrb 35
  • 74.63 (n)
  • 79.73 (a)
ezrb 36
  • 79 (a)
fruit fly
(Drosophila melanogaster)
Insecta Moe 36
  • 52 (a)
(Caenorhabditis elegans)
Secernentea erm-1 36
  • 57 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.6897 36
  • 54 (a)
Species with no ortholog for EZR:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for EZR Gene

Gene Tree for EZR (if available)
Gene Tree for EZR (if available)

Paralogs for EZR Gene

Paralogs for EZR Gene

Selected SIMAP similar genes for EZR Gene using alignment to 3 proteins: Pseudogenes for EZR Gene

genes like me logo Genes that share paralogs with EZR: view

Variants for EZR Gene

Sequence variations from dbSNP and Humsavar for EZR Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type MAF
rs729892 -- 158,787,857(+) AATCC(C/T)GACCC intron-variant
rs744893 -- 158,781,208(+) ACCAA(C/G)TTGTC intron-variant
rs753017 -- 158,773,756(-) CTCGG(A/C)CGCTT intron-variant
rs753018 -- 158,772,877(+) ACATC(C/G)GAGAA intron-variant
rs756144 -- 158,786,558(+) ACCCC(A/G)AAACT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for EZR Gene

Variant ID Type Subtype PubMed ID
esv268739 CNV Insertion 20981092
esv272622 CNV Insertion 20981092
dgv1164e199 CNV Deletion 23128226
esv1726695 CNV Deletion 17803354
esv2733015 CNV Deletion 23290073
esv2733016 CNV Deletion 23290073
esv2733018 CNV Deletion 23290073
esv992884 CNV Deletion 20482838
esv1316592 CNV Deletion 17803354

Relevant External Links for EZR Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for EZR Gene

Disorders for EZR Gene

(2) University of Copenhagen DISEASES for EZR Gene

(62) Novoseek inferred disease relationships for EZR Gene

Disease -log(P) Hits PubMed IDs
neurofibromatosis type 2 83.6 12
osteosarcoma 51.1 48
tumors 50.3 130
metastasis 49.5 80
meningioma 48.7 5

Relevant External Links for EZR

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
genes like me logo Genes that share disorders with EZR: view

No data available for UniProtKB/Swiss-Prot for EZR Gene

Publications for EZR Gene

  1. Identification of the two major epidermal growth factor-induced tyrosine phosphorylation sites in the microvillar core protein ezrin. (PMID: 1382070) Krieg J. … Hunter T. (J. Biol. Chem. 1992) 3 4 23
  2. Ca2+-dependent binding and activation of dormant ezrin by dimeric S100P. (PMID: 12808036) Koltzscher M. … Gerke V. (Mol. Biol. Cell 2003) 3 4 23
  3. Podocalyxin increases the aggressive phenotype of breast and prostate cancer cells in vitro through its interaction with ezrin. (PMID: 17616675) Sizemore S. … Casey G. (Cancer Res. 2007) 3 4 23
  4. Interaction of ezrin with the novel guanine nucleotide exchange factor PLEKHG6 promotes RhoG-dependent apical cytoskeleton rearrangements in epithelial cells. (PMID: 17881735) D'Angelo R. … Arpin M. (Mol. Biol. Cell 2007) 3 4 23
  5. Atypical protein kinase C (iota) activates ezrin in the apical domain of intestinal epithelial cells. (PMID: 18270268) Wald F.A. … Salas P.J. (J. Cell Sci. 2008) 3 4 23

Products for EZR Gene

  • Addgene plasmids for EZR

Sources for EZR Gene

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