EXOSC9 Gene
protein-coding GIFtS: 59
GCID: GC04P122722
|
|
exosome component 9(Previous names: polymyositis/scleroderma autoantigen 1, 75kDa )
(Previous symbol: PMSCL1)
| |
Aliases
for EXOSC9 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Exosome Component 91 2 3 | | P75 Polymyositis-Scleroderma Overlap Syndrome-Associated Autoantigen2 3 | | PMSCL11 2 3 5 | | Exosome Complex Component RRP452 | | PM/Scl-751 2 3 | | Exosome Complex Exonuclease RRP452 | | RRP451 2 | | P75 Polymyositis-Scleroderma Overlap Syndrome Associated Autoantigen2 | | Rrp45p1 2 | | PMSCL Autoantigen, 75kD2 | | P51 | | Polymyositis/Scleroderma Autoantigen 13 | | P61 | | Polymyositis/Scleroderma Autoantigen 75 KDa3 | | Polymyositis/Scleroderma Autoantigen 1, 75kDa1 2 | | EC 3.1.138 | | Autoantigen PM/Scl 12 3 | | |
Export aliases for EXOSC9 gene to outside databasesPrevious GC identifers: GC04P123182 GC04P123080 GC04P122941 GC04P118449 |
Summaries
for EXOSC9 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for EXOSC9:
This gene encodes a component of the human exosome, a exoribonuclease complex which processes and degrades RNA in thenucleus and cytoplasm. This component may play a role in mRNA degradation and the polymyositis/scleroderma autoantigencomplex. Alternative splicing results in multiple transcript variants. (provided by RefSeq, Aug 2011)
UniProtKB/Swiss-Prot: EXOS9_HUMAN, Q06265Function: Non-catalytic component of the RNA exosome complex which has 3'->5' exoribonuclease activity and participatesin a multitude of cellular RNA processing and degradation events. In the nucleus, the RNA exosome complex is involvedin proper maturation of stable RNA species such as rRNA, snRNA and snoRNA, in the elimination of RNA processingby-products and non-coding 'pervasive' transcripts, such as antisense RNA species and promoter-upstream transcripts(PROMPTs), and of mRNAs with processing defects, thereby limiting or excluding their export to the cytoplasm. The RNAexosome may be involved in Ig class switch recombination (CSR) and/or Ig variable region somatic hypermutation (SHM)by targeting AICDA deamination activity to transcribed dsDNA substrates. In the cytoplasm, the RNA exosome complex isinvolved in general mRNA turnover and specifically degrades inherently unstable mRNAs containing AU-rich elements(AREs) within their 3' untranslated regions, and in RNA surveillance pathways, preventing translation of aberrantmRNAs. It seems to be involved in degradation of histone mRNA. The catalytic inactive RNA exosome core complex of 9subunits (Exo-9) is proposed to play a pivotal role in the binding and presentation of RNA for ribonucleolysis, and toserve as a scaffold for the association with catalytic subunits and accessory proteins or complexes. EXOSC9 binds toARE-containing RNAs
Gene Wiki entry for EXOSC9 (Exosome component 9)
|
Genomic Views
for EXOSC9 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000004.11 NC_018915.1 NT_016354.19
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the EXOSC9 gene promoter:
STAT5B STAT1 STAT4 HTF STAT1beta STAT5A STAT1alpha Egr-2 STAT2 STAT3
Other transcription factors
Search SABiosciences Chromatin IP Primers for EXOSC9
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat EXOSC9 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 4q27 Ensembl cytogenetic band: 4q27 HGNC cytogenetic band: 4q27EXOSC9 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 4 GeneLoc Exon Structure GeneLoc location for GC04P122722: view genomic region
(about GC identifiers)
Start:
|
122,722,472 bp from pter |
End:
|
122,738,176 bp from pter |
Size:
|
15,705 bases |
Orientation:
|
plus strand |
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Proteins
for EXOSC9 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: EXOS9_HUMAN, Q06265 (See
protein sequence)Recommended Name: Exosome complex component RRP45 Size: 439 amino acids; 48949 Da
Subunit: Component of the RNA exosome complex. Specifically part of the catalytically inactive RNA exosome core (Exo-9)complex which is believed to associate with catalytic subunits EXOSC10, and DIS3 or DIS3L in cytoplasmic- andnuclear-specific RNA exosome complex forms. Exo-9 is formed by a hexameric ring of RNase PH domain-containing subunitsspecifically containing the heterodimers EXOSC4-EXOSC9, EXOSC5-EXOSC8 and EXOSC6-EXOSC7, and peripheral S1domain-containing components EXOSC1, EXOSC2 and EXOSC3 located on the top of the ring structure
Subcellular location: Cytoplasm. Nucleus, nucleolus
Subcellular location: Isoform 1: Nucleus, nucleolus
Subcellular location: Isoform 2: Nucleus, nucleolus
Subcellular location: Isoform 3: Nucleus. Note=Excluded from the nucleolus
Caution: The six exosome core subunits containing a RNase PH-domain are not phosphorolytically active
1 PDB 3D structure from  and Proteopedia  for EXOSC9:2NN6 (3D)
Secondary accessions: Q12883 Q4W5P5 Q86Y41 Q86Y48Alternative splicing: 4 isoforms: Q06265-1 Q06265-2 Q06265-3 Q06265-4 Explore the universe of human proteins at neXtProt for EXOSC9: NX_Q06265
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q06265
2 DME Specific Peptides for EXOSC9 (Q06265)
EXOSC9 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (2 alternative transcripts):
NP_001029366.1 NP_005024.2
ENSEMBL proteins: ENSP00000243498 ENSP00000368984 ENSP00000423476 ENSP00000421845 ENSP00000422205 ENSP00000425782 ENSP00000424504 Reactome Protein details: Q06265
Human Recombinant Protein Products for EXOSC9:
Gene Ontology (GO): 5/6 cellular component terms (GO ID links to tree view) (see all 6): About this table
EXOSC9 for ontologies About GeneDecksing
EXOSC9 Antibody Products:
Assay Products for EXOSC9: |
Protein
Domains /
Families
for EXOSC9 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
EXOSC9 for domains About GeneDecksing
3 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q06265ProtoNet protein and cluster: Q06265 UniProtKB/Swiss-Prot: EXOS9_HUMAN, Q06265Similarity: Belongs to the RNase PH family |
Function
for EXOSC9 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
inGenious Targeting Laboratory,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase,
shRNA from
OriGene,
Sirion Biotech,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Sirion Biotech,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
Sirion Biotech,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Molecular Function:
UniProtKB/Swiss-Prot Summary: EXOS9_HUMAN, Q06265Function: Non-catalytic component of the RNA exosome complex which has 3'->5' exoribonuclease activity and participatesin a multitude of cellular RNA processing and degradation events. In the nucleus, the RNA exosome complex is involvedin proper maturation of stable RNA species such as rRNA, snRNA and snoRNA, in the elimination of RNA processingby-products and non-coding 'pervasive' transcripts, such as antisense RNA species and promoter-upstream transcripts(PROMPTs), and of mRNAs with processing defects, thereby limiting or excluding their export to the cytoplasm. The RNAexosome may be involved in Ig class switch recombination (CSR) and/or Ig variable region somatic hypermutation (SHM)by targeting AICDA deamination activity to transcribed dsDNA substrates. In the cytoplasm, the RNA exosome complex isinvolved in general mRNA turnover and specifically degrades inherently unstable mRNAs containing AU-rich elements(AREs) within their 3' untranslated regions, and in RNA surveillance pathways, preventing translation of aberrantmRNAs. It seems to be involved in degradation of histone mRNA. The catalytic inactive RNA exosome core complex of 9subunits (Exo-9) is proposed to play a pivotal role in the binding and presentation of RNA for ribonucleolysis, and toserve as a scaffold for the association with catalytic subunits and accessory proteins or complexes. EXOSC9 binds toARE-containing RNAs Enzyme Number (IUBMB): EC 3.1.132
Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view): About this table
EXOSC9 for ontologies About GeneDecksing
Animal Models:
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for EXOSC9 (see all 4)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for EXOSC9 (see all 2)
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector (see all 2): EXOSC9 (NM_005033) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for EXOSC9 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat EXOSC9 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for EXOSC9 |
|
Pathways & Interactions
for EXOSC9 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways - 5/6 super-pathways (see all 6) About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Destabilization of mRNA by Tristetraprolin (TTP) | | | 2 | Deadenylation-dependent mRNA decay | | | 3 | Metabolism of mRNA | | | 4 | ATP/ITP metabolism | | | 5 | Ubiquitinated Orc1 is degraded by the proteasome | |
Pathway sources
See GeneCards unified pathways
Show all pathways
1 EMD Millipore Pathway for EXOSC9
1  GeneGo (Thomson Reuters) Pathway for EXOSC9
5/9 
Reactome Pathways for EXOSC9 (see all 9)
1 
Kegg Pathway (Kegg details for EXOSC9):
EXOSC9 for pathways About GeneDecksing
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for EXOSC9
STRING Interaction
Network Preview (showing 5 interactants - click image to see 25)
5/83 Interacting proteins for EXOSC9 (Q062652, 3 ENSP000003689844) via UniProtKB, MINT, STRING, and/or I2D (see all 83)| Interactant | Interaction Details |
|---|
| GeneCard | External ID(s) |
|---|
| EXOSC1 | Q9Y3B22, 3, ENSP000003599394 | MINT-7993644 MINT-7993893 MINT-7993837 MINT-7988296 MINT-7993717 I2D:
score=2 STRING: ENSP00000359939 | | EXOSC7 | Q150242, 3, ENSP000002655644 | MINT-7993644 MINT-7993893 MINT-7993837 MINT-7988296 MINT-7993717 I2D:
score=2 STRING: ENSP00000265564 | | EXOSC5 | Q9NQT42, 3, ENSP000002212334 | MINT-7993644 MINT-7993837 MINT-7988296 MINT-7993717 I2D:
score=1 STRING: ENSP00000221233 | | EXOSC6 | Q5RKV62, 3, ENSP000003985974 | MINT-7993644 MINT-7993837 MINT-7988296 I2D:
score=1 STRING: ENSP00000398597 | | EXOSC4 | Q9NPD32, 3, ENSP000003154764 | MINT-7993644 MINT-7993893 MINT-7993837 MINT-7988296 MINT-7993717 I2D:
score=11 STRING: ENSP00000315476 |
About this table
Gene Ontology (GO): 5/11 biological process terms (GO ID links to tree view) (see all 11): About this table
EXOSC9 for ontologies About GeneDecksing
|
Drugs & Compounds
for EXOSC9 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for EXOSC9
Search CenterWatch for drugs/clinical trials and news about EXOSC9 / EXOS9
|
Transcripts
for EXOSC9 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
Sirion Biotech,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for EXOSC9 gene (2 alternative transcripts): NM_001034194.1 NM_005033.2 Unigene Cluster for EXOSC9: Exosome component 9 Hs.91728 [show with all ESTs]Unigene Representative Sequence: NM_00103419412 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000243498 ENST00000509980 ENST00000379663 ENST00000513654(uc003idz.3 uc003iea.3)
ENST00000511454 ENST00000509800 ENST00000512454(uc003ieb.3) ENST00000508212
ENST00000506201 ENST00000511132 ENST00000503139(uc010inp.1) ENST00000503236
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for EXOSC9 (see all 4)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for EXOSC9 (see all 2)
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector (see all 2): EXOSC9 (NM_005033) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for EXOSC9 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat EXOSC9 |
Additional cDNA sequence: AJ505989.1 AJ517294.1 AK301967.1 AK307548.1 AK310894.1 BC012371.1 BC142978.1 M58460.1 U09215.1 20 DOTS entries: DT.101957287 DT.100776190 DT.91774285 DT.95341720 DT.101981094 DT.100713798 DT.91942856 DT.91774289 DT.100036712 DT.100700269 DT.100713796 DT.95341715 DT.100022996 DT.91774290 DT.121257011 DT.407371 DT.455397 DT.91965981 DT.95341757 DT.91996848 24/196 AceView cDNA sequences (see all 196): AA937087 CR600057 CR595328 AU117956 BC012371 BM991858 BF940295 BE046954 BU195002 CR596830 U09215 AI309188 M58460 BU620987 BF974787 BE253559 BE079624 BX340304 AI521790 NM_005033 F11188 AW615244 BI830420 AA316393
GeneLoc Exon Structure
5/8 Alternative Splicing Database (ASD) splice patterns (SP) for EXOSC9 (see all 8) About this scheme
| ExUns: | 1a | · | 1b | ^ | 2 | ^ | 3a | · | 3b | ^ | 4 | ^ | 5a | · | 5b | ^ | 6a | · | 6b | ^ | 7 | ^ | 8a | · | 8b | ^ | 9 | ^ | 10a | · | 10b | ^ | 11a | · | 11b | · | 11c | · | 11d | ^ | 12 | ^ | 13a | · | 13b | ^ | 14 |
|---|
|
| SP1: | | | | | | | | | | | | | - | | | | | | - | | - | | | | | | | | | | | | - | | | | | | - | | | | | | | | | | |
| SP2: | | | | | | | | | | | | | - | | | | | | - | | - | | | | | | | | | | | | - | | | | | | - | | - | | | | | | | | |
| SP3: | | | | | | | | | | | | | - | | | | | | - | | - | | | | - | | | | | | | | - | | | | | | | | | | | | | | | | |
| SP4: | | | | | | | | | | | | | - | | | | | | - | | | | - | | - | | | | | | | | | | | | | | | | | | | | | | | | |
| SP5: | | | | | | | | | | | | | - | | - | | | | - | | - | | | | | | | | | | | | | | | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for EXOSC9
|
Expression
for EXOSC9 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| EXOSC9 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: AACAAACATC
About this image
See EXOSC9 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for EXOSC9
SOURCE GeneReport for Unigene cluster: Hs.91728
SABiosciences Custom PCR Arrays for EXOSC9
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for EXOSC9
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat EXOSC9 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat EXOSC9 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat EXOSC9 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for EXOSC9 |
Orthologs
for EXOSC9 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of eukaryotes.
Orthologs for EXOSC9 gene from 10/35 species (see all 35) About this table
ENSEMBL Gene Tree for EXOSC9 (if available)
TreeFam Gene Tree for EXOSC9 (if available) |
Paralogs
for EXOSC9 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for EXOSC9 gene
- EXOSC82 EXOSC72
2 SIMAP similar genes for EXOSC9 using alignment to 7 protein entries: EXOS9_HUMAN (see all proteins):EXOSC8 DKFZp564C0482
EXOSC9 for paralogs About GeneDecksing
|
Genomic Variants
for EXOSC9 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 4 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for EXOSC9 (122722472 - 122738176 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for EXOSC9: -- | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing EXOSC9 |
|
Disorders
/ Diseases
for EXOSC9 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
EXOSC9 for disorders About GeneDecksing
OMIM gene information: 606180
OMIM disorders: --
4  diseases for EXOSC9: About MalaCardspolymyositis scleroderma systemic scleroderma malaria
Export disorders for EXOSC9 gene to outside databases
|
Publications
for EXOSC9 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for EXOSC9 gene, integrated from 9 sources (see all 42):
(articles sorted by number of sources associating them with EXOSC9) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Dis3-like 1: a novel exoribonuclease associated with the human exosome. (PubMed id 20531389)1, 2 Staals R.H....Pruijn G.J. (2010)
- Human cell growth requires a functional cytoplasmic exosome, which is involved in various mRNA decay pathways. (PubMed id 17545563)1, 2 van Dijk E.L....Pruijn G.J. (2007)
- Reconstitution, activities, and structure of the eukaryotic RNA exosome. (PubMed id 17174896)1, 2 Liu Q.... Lima C.D. (2006)
- Adenylation and exosome-mediated degradation of cotranscriptionally cleaved pre-messenger RNA in human cells. (PubMed id 16455498)1, 2 West S.... Proudfoot N.J. (2006)
- Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)1, 2 Olsen J.V....Mann M. (2006)
- The association of the human PM/Scl-75 autoantigen with the exosome is dependent on a newly identified N terminus. (PubMed id 12788944)1, 2 Raijmakers R.... Pruijn G.J. (2003)
- The mammalian exosome mediates the efficient degradation of mRNAs that contain AU-rich elements. (PubMed id 11782436)1, 2 Mukherjee D....Wilusz J. (2002)
- AU binding proteins recruit the exosome to degrade ARE-containing mRNAs. (PubMed id 11719186)1, 2 Chen C.-Y.... Karin M. (2001)
- The yeast exosome and human PM-Scl are related complexes of 3'-->5' exonucleases. (PubMed id 10465791)1, 2 Allmang C....Mitchell P. (1999)
- Molecular characterization of an autoantigen of PM-Scl in the polymyositis/scleroderma overlap syndrome: a unique and complete human cDNA encoding an apparent 75-kD acidic protein of the nucleolar complex. (PubMed id 2007859)1, 2 Alderuccio F.... Tan E.M. (1991)
|
External Searches for EXOSC9 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing EXOSC9 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing EXOSC9 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing EXOSC9 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
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| Name | Description |
| PharmGKB entry for EXOSC9 | Pharmacogenomics, SNPs, Pathways |
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About This Section
| Patent Information for EXOSC9 gene:
Search GeneIP for patents involving EXOSC9
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
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Products
for EXOSC9 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory)
About This Section
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| | |  | OriGene Antibodies for EXOSC9 | | OriGene shRNA RFP for EXOSC9 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for EXOSC9 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for EXOSC9 | | | OriGene Protein Over-expression Lysate for EXOSC9 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for EXOSC9 | | OriGene 3'-UTR Clone for EXOSC9 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for EXOSC9 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for EXOSC9 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | OriGene Purified Protein for EXOSC9 | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for EXOSC9 | | OriGene Custom Protein Services for EXOSC9 | | | OriGene Custom Immunoassay Development | | |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat EXOSC9 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing EXOSC9 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat EXOSC9 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat EXOSC9 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat EXOSC9 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat EXOSC9 |
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| | | | Search Tocris compounds for EXOSC9 |
| |  |  |  |  | | | | | | Recombinant Protein for EXOSC9 |
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 | | | EXOSC9 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for EXOSC9 |
|  |  |  |  | | | | ThermoFisher Antibody for EXOSC9 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat EXOSC9 |
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