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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

EXOSC8 Gene

protein-coding   GIFtS: 57
GCID: GC13P037572

exosome component 8
 Explore 3 diseases affiliated with
EXOSC8 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for EXOSC8    

Aliases
for EXOSC8 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Exosome Component 81 2 3     Opa-Interacting Protein 22 3
OIP21 2 3 5     Ribosomal RNA-Processing Protein 432 3
RRP431 2 3 5     OIP-22 3
P91     RP11-421P11.32
CIP31 2     CBP-Interacting Protein 32
EAP21 2     Exosome Complex Component RRP432
Rrp43p1 2     Exosome Complex Exonuclease RRP432
BA421P11.31     Opa Interacting Protein 22

External Ids:    HGNC: 170351   Entrez Gene: 113402   Ensembl: ENSG000001206997   OMIM: 6060195   UniProtKB: Q96B263   

Export aliases for EXOSC8 gene to outside databases

Previous GC identifers: GC13P035373 GC13P036472 GC13P018386


Summaries
for EXOSC8 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for EXOSC8:
This gene encodes a 3'-5' exoribonuclease that specifically interacts with mRNAs containing AU-rich elements. The
encoded protein is part of the exosome complex that is important for the degradation of numerous RNA species. A
pseudogene of this gene is found on chromosome 6. (provided by RefSeq, Mar 2009)

UniProtKB/Swiss-Prot: EXOS8_HUMAN, Q96B26
Function: Non-catalytic component of the RNA exosome complex which has 3'->5' exoribonuclease activity and participates
in a multitude of cellular RNA processing and degradation events. In the nucleus, the RNA exosome complex is involved
in proper maturation of stable RNA species such as rRNA, snRNA and snoRNA, in the elimination of RNA processing
by-products and non-coding 'pervasive' transcripts, such as antisense RNA species and promoter-upstream transcripts
(PROMPTs), and of mRNAs with processing defects, thereby limiting or excluding their export to the cytoplasm. The RNA
exosome may be involved in Ig class switch recombination (CSR) and/or Ig variable region somatic hypermutation (SHM)
by targeting AICDA deamination activity to transcribed dsDNA substrates. In the cytoplasm, the RNA exosome complex is
involved in general mRNA turnover and specifically degrades inherently unstable mRNAs containing AU-rich elements
(AREs) within their 3' untranslated regions, and in RNA surveillance pathways, preventing translation of aberrant
mRNAs. It seems to be involved in degradation of histone mRNA. The catalytic inactive RNA exosome core complex of 9
subunits (Exo-9) is proposed to play a pivotal role in the binding and presentation of RNA for ribonucleolysis, and to
serve as a scaffold for the association with catalytic subunits and accessory proteins or complexes. EXOSC8 binds to
ARE-containing RNAs

Gene Wiki entry for EXOSC8 (Exosome component 8)


Genomic Views
for EXOSC8 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000013.10  NC_018924.1  NT_024524.14  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the EXOSC8 gene promoter:
         GR   GR-beta   Lmo2   Tal-1beta   MEF-2A   GR-alpha   aMEF-2   ITF-2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: EXOSC8 promoter sequence
   Search SABiosciences Chromatin IP Primers for EXOSC8

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat EXOSC8


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 13q13.1   Ensembl cytogenetic band:  13q13.3   HGNC cytogenetic band: 13q13.1

EXOSC8 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
EXOSC8 gene location

GeneLoc information about chromosome 13         GeneLoc Exon Structure

GeneLoc location for GC13P037572:  view genomic region     (about GC identifiers)

Start:
 37,572,953 bp from pter      End:
 37,583,751 bp from pter
Size:
 10,799 bases      Orientation:
 plus strand

Proteins
for EXOSC8 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: EXOS8_HUMAN, Q96B26 (See protein sequence)
Recommended Name: Exosome complex component RRP43  
Size: 276 amino acids; 30040 Da
Subunit: Component of the RNA exosome complex. Specifically part of the catalytically inactive RNA exosome core (Exo-9)
complex which is believed to associate with catalytic subunits EXOSC10, and DIS3 or DIS3L in cytoplasmic- and
nuclear-specific RNA exosome complex forms. Exo-9 is formed by a hexameric ring of RNase PH domain-containing subunits
specifically containing the heterodimers EXOSC4-EXOSC9, EXOSC5-EXOSC8 and EXOSC6-EXOSC7, and peripheral S1
domain-containing components EXOSC1, EXOSC2 and EXOSC3 located on the top of the ring structure. Binds outer membrane
protein opap from Neisseria gonorrhoeae
Subcellular location: Cytoplasm. Nucleus. Nucleus, nucleolus (By similarity)
Caution: The six exosome core subunits containing a RNase PH-domain are not phosphorolytically active
Sequence caution: Sequence=CAI14013.1; Type=Erroneous gene model prediction; Sequence=EAX08581.1; Type=Erroneous gene
model prediction;
1 PDB 3D structure from and Proteopedia for EXOSC8:
2NN6 (3D)    
Secondary accessions: O43480 Q5TBA5

Explore the universe of human proteins at neXtProt for EXOSC8: NX_Q96B26

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q96B26

    • EXOSC8 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_852480.1  
    ENSEMBL proteins: 
     ENSP00000374354   ENSP00000239893   ENSP00000419203  
    Reactome Protein details: Q96B26
    Human Recombinant Protein Products: 
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    Novus Biologicals EXOSC8 Proteins
    Novus Biologicals EXOSC8 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for EXOSC8

    Gene Ontology (GO): 5 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000178exosome (RNase complex) IDA--
    GO:0005634nucleus IDA17545563
    GO:0005730nucleolus IEA--
    GO:0005737cytoplasm IDA17545563
    GO:0005829cytosol TAS--


    EXOSC8 for ontologies           About GeneDecksing



    EXOSC8 Antibody Products: 
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    Abcam antibodies for EXOSC8 
    Uscn Antibodies for EXOSC8
    ThermoFisher Antibodies for EXOSC8

    Assay Products for EXOSC8: 
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    GenScript Custom Assay Services for EXOSC8
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    Uscn ELISAs and CLIAs for EXOSC8

    Protein Domains /
    Families
    for EXOSC8 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    EXOSC8 for domains           About GeneDecksing

    3 InterPro domains/families:
     IPR015847 ExoRNase_PH_dom2
     IPR001247 ExoRNase_PH_dom1
     IPR020568 Ribosomal_S5_D2-typ_fold

    Graphical View of Domain Structure for InterPro Entry Q96B26

    ProtoNet protein and cluster: Q96B26

    UniProtKB/Swiss-Prot: EXOS8_HUMAN, Q96B26
    Similarity: Belongs to the RNase PH family


    Function
    for EXOSC8 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: EXOS8_HUMAN, Q96B26
    Function: Non-catalytic component of the RNA exosome complex which has 3'->5' exoribonuclease activity and participates
    in a multitude of cellular RNA processing and degradation events. In the nucleus, the RNA exosome complex is involved
    in proper maturation of stable RNA species such as rRNA, snRNA and snoRNA, in the elimination of RNA processing
    by-products and non-coding 'pervasive' transcripts, such as antisense RNA species and promoter-upstream transcripts
    (PROMPTs), and of mRNAs with processing defects, thereby limiting or excluding their export to the cytoplasm. The RNA
    exosome may be involved in Ig class switch recombination (CSR) and/or Ig variable region somatic hypermutation (SHM)
    by targeting AICDA deamination activity to transcribed dsDNA substrates. In the cytoplasm, the RNA exosome complex is
    involved in general mRNA turnover and specifically degrades inherently unstable mRNAs containing AU-rich elements
    (AREs) within their 3' untranslated regions, and in RNA surveillance pathways, preventing translation of aberrant
    mRNAs. It seems to be involved in degradation of histone mRNA. The catalytic inactive RNA exosome core complex of 9
    subunits (Exo-9) is proposed to play a pivotal role in the binding and presentation of RNA for ribonucleolysis, and to
    serve as a scaffold for the association with catalytic subunits and accessory proteins or complexes. EXOSC8 binds to
    ARE-containing RNAs

    miRNA
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    hsa-miR-7-2* hsa-miR-7-1* hsa-miR-16-1*
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
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    OriGene shRNA RFP: EXOSC8
    OriGene siRNA: EXOSC8
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat EXOSC8

    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for EXOSC8

    Clone
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    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for EXOSC8 (see all 4)
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    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat EXOSC8 

    Cell Line
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    Search LifeMap BioReagents cell lines for EXOSC8

    In Situ Assay
    Products:       
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    Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004532NOT exoribonuclease activity IDA17174896
    GO:0005515protein binding IPI--
    GO:0017091AU-rich element binding IDA16912217


    EXOSC8 for ontologies           About GeneDecksing


    2 GenomeRNAi human phenotypes for EXOSC8:
     Small cells  Synthetic lethal with Ras 

    Animal Models:
         1 MGI phenotypic allele for Exosc8 (no phenotypes)

    EXOSC8 for phenotypes           About GeneDecksing


    Pathways & Interactions
    for EXOSC8 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways - 5/6 super-pathways (see all 6) About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Destabilization of mRNA by Tristetraprolin (TTP)
    		Destabilization of mRNA by Tristetraprolin (TTP)1.00
    		mRNA Decay by 3' to 5' Exoribonuclease0.56
    		Destabilization of mRNA by Butyrate Response Factor 1 (BRF1)0.79
    		Destabilization of mRNA by KSRP0.48
    2Deadenylation-dependent mRNA decay
    		Deadenylation-dependent mRNA decay1.00
    		RNA degradation0.50
    3Metabolism of mRNA
    		Metabolism of mRNA1.00
    		Metabolism of RNA0.92
    4ATP/ITP metabolism
    		ATP/ITP metabolism1.00
    		ATP/ITP metabolism0.98
    5Ubiquitinated Orc1 is degraded by the proteasome
    		Regulation of mRNA Stability by Proteins that Bind AU-rich Elements0.55

    Pathway sources
    See GeneCards unified pathways
    Show all pathways

    1 EMD Millipore Pathway for EXOSC8
        ATP/ITP metabolism


    1 GeneGo (Thomson Reuters) Pathway for EXOSC8
        ATP/ITP metabolism

    5/9        Reactome Pathways for EXOSC8 (see all 9)
        Regulation of mRNA Stability by Proteins that Bind AU-rich Elements
    Destabilization of mRNA by Butyrate Response Factor 1 (BRF1)
    Destabilization of mRNA by KSRP
    mRNA Decay by 3' to 5' Exoribonuclease
    Deadenylation-dependent mRNA decay


    1         Kegg Pathway  (Kegg details for EXOSC8):
        RNA degradation


    EXOSC8 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for EXOSC8

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/52 Interacting proteins for EXOSC8 (Q96B261, 2, 3 ENSP000003743544) via UniProtKB, MINT, STRING, and/or I2D (see all 52)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    EXOSC5Q9NQT41, 2, 3, ENSP000002212334EBI-371922,EBI-371876 MINT-7993644 MINT-7993837 MINT-7988296 MINT-7993717 I2D: score=4 STRING: ENSP00000221233
    EXOSC1Q9Y3B22, 3, ENSP000003599394MINT-7993644 MINT-7993893 MINT-7993837 MINT-7988296 MINT-7993717 I2D: score=2 STRING: ENSP00000359939
    EXOSC7Q150242, 3, ENSP000002655644MINT-7993644 MINT-7993893 MINT-7993837 MINT-7988296 MINT-7993717 I2D: score=2 STRING: ENSP00000265564
    EXOSC9Q062652, 3, ENSP000003689844MINT-7993644 MINT-7993893 MINT-7993837 MINT-7988296 MINT-7993717 I2D: score=1 STRING: ENSP00000368984
    EXOSC6Q5RKV62, 3, ENSP000003985974MINT-7993644 MINT-7993837 MINT-7988296 I2D: score=3 STRING: ENSP00000398597
    About this table

    Gene Ontology (GO): 5/7 biological process terms (GO ID links to tree view) (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000288nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay TAS--
    GO:0006364rRNA processing IEA--
    GO:0008150biological_process ND--
    GO:0010467gene expression TAS--
    GO:0016070RNA metabolic process TAS--


    EXOSC8 for ontologies           About GeneDecksing



    Drugs & Compounds
    for EXOSC8 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for EXOSC8
    Search CenterWatch for drugs/clinical trials and news about EXOSC8 / EXOS8 

    Transcripts
    for EXOSC8 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for EXOSC8 gene: 
    NM_181503.2  

    Unigene Cluster for EXOSC8:

    Exosome component 8
    Hs.294041  [show with all ESTs]
    Unigene Representative Sequence: AL050353
    11 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000489088 ENST00000389704(uc001uvz.2 uc001uwa.3) ENST00000239893
    ENST00000474661 ENST00000490537 ENST00000488108 ENST00000464235 ENST00000488779
    ENST00000470423 ENST00000495092 ENST00000481013

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat EXOSC8
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    hsa-miR-7-2* hsa-miR-7-1* hsa-miR-16-1*
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    Inhib. RNA
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    OriGene shRNA RFP: EXOSC8
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    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat EXOSC8
    Clone
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      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat EXOSC8

    Additional cDNA sequence: 

    AF025438.1 AL050353.1 BC020773.1 

    15 DOTS entries:

    DT.95172126  DT.100039725  DT.447707  DT.100828891  DT.120794375  DT.91985875  DT.100828863  DT.86998283 
    DT.92454817  DT.95172113  DT.95200281  DT.100828887  DT.95172124  DT.100703520  DT.433386 

    24/302 AceView cDNA sequences (see all 302):

    CD677122 BX481599 CR595030 BU943696 AA916723 AA236789 BM904094 BM991947 
    AI337332 AA024685 BE501119 BX641448 AI073755 AA928158 CR602904 CA314262 
    AA451907 AA913049 CD673582 BU729389 BM703462 CB110833 AI678339 AA532854 

    GeneLoc Exon Structure

    5/6 Alternative Splicing Database (ASD) splice patterns (SP) for EXOSC8 (see all 6)    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6a · 6b · 6c ^ 7a · 7b · 7c ^ 8 ^ 9 ^ 10 ^ 11 ^ 12
    SP1:                                -     -     -           -                                             
    SP2:                                                                                                      
    SP3:                                                        -     -                                       
    SP4:                                                                                                      
    SP5:        -     -                                                                                       


    ECgene alternative splicing isoforms for EXOSC8

    Expression
    for EXOSC8 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    EXOSC8 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: --

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    EXOSC8 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    1 LifeMap In Vivo Development Anatomical Compartment/Cell 
    Tissue Anatomical Compartment CellCategory (developmental path)
    OvaryPrimary FolliclePrimary OocyteFemale Gametocytes, Germ Cells
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization

    See EXOSC8 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for EXOSC8

    SOURCE GeneReport for Unigene cluster: Hs.294041
        SABiosciences Custom PCR Arrays for EXOSC8
    Primer
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    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat EXOSC8
    In Situ
    Assay Products:     
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for EXOSC8

    Orthologs
    for EXOSC8 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of eukaryotes.

    Orthologs for EXOSC8 gene from 7/29 species (see all 29)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves LOC1008585601 exosome complex component RRP43-like 78.74(n)
    82.97(a)    		   100858560  XM_003640577.1  XP_003640625.1 
    lizard
    (Anolis carolinensis)    		 Reptilia EXOSC86
    		 --
    		 77(a)
    		 1 ↔ 1
    		 2(82535554-82548439)
    African clawed frog
    (Xenopus laevis)    		 Amphibia MGC528472 hypothetical protein MGC52847 75.02(n)    BC041271.1 
    zebrafish
    (Danio rerio)    		 Actinopterygii exosc81 exosome component 8 69.46(n)
    70.8(a)    		   323016  NM_001002865.1  NP_001002865.1 
    mosquito
    (Anopheles gambiae)    		 Insecta AgaP_AGAP0124021 AGAP012402-PA 53.72(n)
    48.08(a)    		   1280314  XM_320154.3  XP_320154.3 
    thale cress
    (Arabidopsis thaliana)    		 eudicotyledons AT1G600801 3' exoribonuclease domain 1-containing protein 49.24(n)
    37.88(a)    		   842303  NM_104700.4  NP_176216.1 
    rice
    (Oryza sativa)    		 Liliopsida Os11g03113001 hypothetical protein 46.21(n)
    34.85(a)    		   4350355  NM_001074290.1  NP_001067758.1 


    ENSEMBL Gene Tree for EXOSC8 (if available)
    TreeFam Gene Tree for EXOSC8 (if available) 

    Paralogs
    for EXOSC8 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for EXOSC8 gene
    EXOSC92  EXOSC72  
    3 SIMAP similar genes for EXOSC8 using alignment to 3 protein entries:     EXOS8_HUMAN (see all proteins):
    DKFZp564C0482    EXOSC9    EXOSC7

    EXOSC8 for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for EXOSC8
    PGOHUM00000243177


    Genomic Variants
    for EXOSC8 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/186 NCBI SNPs in EXOSC8 are shown (see all 186)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 13 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs21861571,2
    		C,H,--37572948(+) AAGGGG/AGCAGG 3 -- int1 us2k114Minor allele frequency- A:0.05NA WA CSA EA 377
    rs1886049811,2
    		--37572994(+) CCCTGC/GGTGGA 3 -- int1 us2k10--------
    rs1414125531,2
    		--37572999(+) GGTGGA/GGCAGA 3 -- int1 us2k10--------
    rs1450059031,2
    		--37573058(+) CAGAGG/TAGGTG 3 -- int1 us2k10--------
    rs1467789351,2
    		--37573209(+) AAGGAA/GAGTGA 3 -- us2k1 int10--------
    rs1125326191,2
    		C,--37573219(+) AAACTC/ACAGGA 3 -- us2k1 int12Minor allele frequency- A:0.04NA WA 120
    rs1406124771,2
    		--37573275(+) TCTCCA/GAGAAC 3 -- int1 us2k10--------
    rs2008949541,2
    		--37573363(+) ATCCCC/TGTTCT 3 -- us2k1 int10--------
    rs95477141,2
    		C,F,H,--37573734(+) CATACG/AACTCA 3 -- us2k17Minor allele frequency- A:0.01NS EA NA 826
    rs767734071,2
    		C--37573763(+) GTTTAG/TTACAT 3 -- us2k10--------

    HapMap Linkage Disequilibrium report for EXOSC8 (37572953 - 37583751 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for EXOSC8: --

    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing EXOSC8
    DNA2.0 Custom Variant and Variant Library Synthesis for EXOSC8

    Disorders / Diseases
    for EXOSC8 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    EXOSC8 for disorders           About GeneDecksing

    OMIM gene information: 606019    OMIM disorders: --

    3 diseases for EXOSC8:    About MalaCards
    cryptococcosis    male breast cancer    breast cancer


    Export disorders for EXOSC8 gene to outside databases

    Publications
    for EXOSC8 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for EXOSC8 gene, integrated from 9 sources (see all 26):
    (articles sorted by number of sources associating them with EXOSC8)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Using the yeast two-hybrid system to identify human epithelial cell proteins that bind gonococcal Opa proteins: intracellular gonococci bind pyruvate kinase via their Opa proteins and require host pyruvate for growth. (PubMed id 9466265)1, 2, 3 Williams J.M.... Rest R.F. (1998)
    2. A protein subunit of human RNase P, Rpp14, and its interacting partner, OIP2, have 3'-->5' exoribonuclease activity. (PubMed id 11929972)1, 3, 9 Jiang T. and Altman S. (2002)
    3. Dis3-like 1: a novel exoribonuclease associated with the human exosome. (PubMed id 20531389)1, 2 Staals R.H....Pruijn G.J. (2010)
    4. Human cell growth requires a functional cytoplasmic exosome, which is involved in various mRNA decay pathways. (PubMed id 17545563)1, 2 van Dijk E.L....Pruijn G.J. (2007)
    5. Reconstitution, activities, and structure of the eukaryotic RNA exosome. (PubMed id 17174896)1, 2 Liu Q.... Lima C.D. (2006)
    6. Sequence-specific RNA binding mediated by the RNase PH domain of components of the exosome. (PubMed id 16912217)1, 2 Anderson J.R....Wilusz J. (2006)
    7. A protein interaction framework for human mRNA degradation. (PubMed id 15231747)1, 2 Lehner B. and Sanderson C.M. (2004)
    8. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    9. Protein-protein interactions between human exosome components support the assembly of RNase PH-type subunits into a six-membered PNPase-like ring. (PubMed id 12419256)1, 2 Raijmakers R.... Pruijn G.J.M. (2002)
    10. AU binding proteins recruit the exosome to degrade ARE-containing mRNAs. (PubMed id 11719186)1, 2 Chen C.-Y.... Karin M. (2001)

    External Searches for EXOSC8 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing EXOSC8 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 11340 HGNC: 17035 AceView: EXOSC8 Ensembl:ENSG00000120699 euGenes: HUgn11340
    ECgene: EXOSC8 Kegg: 11340 H-InvDB: EXOSC8

    Other Databases showing EXOSC8 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing EXOSC8 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for EXOSC8 Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for EXOSC8 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for EXOSC8 gene:
    Search GeneIP for patents involving EXOSC8

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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