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EXOSC8 Gene

protein-coding   GIFtS: 58
GCID: GC13P037572

Exosome Component 8

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Exosome Component 81 2 3     p92 3
OIP22 3 5     CIP32
RRP432 3 5     EAP22
CBP-Interacting Protein 31 2     Rrp43p2
Opa Interacting Protein 21 2     bA421P11.32
Opa-Interacting Protein 22 3     Exosome Complex Component RRP432
Ribosomal RNA-Processing Protein 432 3     Exosome Complex Exonuclease RRP432
OIP-22 3     

External Ids:    HGNC: 170351   Entrez Gene: 113402   Ensembl: ENSG000001206997   OMIM: 6060195   UniProtKB: Q96B263   

Export aliases for EXOSC8 gene to outside databases

Previous GC identifers: GC13P035373 GC13P036472 GC13P018386


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for EXOSC8 Gene:
This gene encodes a 3'-5' exoribonuclease that specifically interacts with mRNAs containing AU-rich elements. The
encoded protein is part of the exosome complex that is important for the degradation of numerous RNA species. A
pseudogene of this gene is found on chromosome 6. (provided by RefSeq, Mar 2009)

GeneCards Summary for EXOSC8 Gene:
EXOSC8 (exosome component 8) is a protein-coding gene. Diseases associated with EXOSC8 include cryptococcosis, and hemophagocytic lymphohistiocytosis. GO annotations related to this gene include exoribonuclease activity and AU-rich element binding. An important paralog of this gene is EXOSC9.

UniProtKB/Swiss-Prot: EXOS8_HUMAN, Q96B26
Function: Non-catalytic component of the RNA exosome complex which has 3'->5' exoribonuclease activity and
participates in a multitude of cellular RNA processing and degradation events. In the nucleus, the RNA exosome
complex is involved in proper maturation of stable RNA species such as rRNA, snRNA and snoRNA, in the elimination
of RNA processing by-products and non-coding 'pervasive' transcripts, such as antisense RNA species and
promoter-upstream transcripts (PROMPTs), and of mRNAs with processing defects, thereby limiting or excluding
their export to the cytoplasm. The RNA exosome may be involved in Ig class switch recombination (CSR) and/or Ig
variable region somatic hypermutation (SHM) by targeting AICDA deamination activity to transcribed dsDNA
substrates. In the cytoplasm, the RNA exosome complex is involved in general mRNA turnover and specifically
degrades inherently unstable mRNAs containing AU-rich elements (AREs) within their 3' untranslated regions, and
in RNA surveillance pathways, preventing translation of aberrant mRNAs. It seems to be involved in degradation of
histone mRNA. The catalytic inactive RNA exosome core complex of 9 subunits (Exo-9) is proposed to play a pivotal
role in the binding and presentation of RNA for ribonucleolysis, and to serve as a scaffold for the association
with catalytic subunits and accessory proteins or complexes. EXOSC8 binds to ARE-containing RNAs

Gene Wiki entry for EXOSC8 (Exosome component 8) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000013.11  NT_024524.15  NC_018924.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the EXOSC8 gene promoter:
         GR   GR-beta   Lmo2   Tal-1beta   MEF-2A   GR-alpha   aMEF-2   ITF-2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidEXOSC8 promoter sequence
   Search Chromatin IP Primers for EXOSC8

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat EXOSC8


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 13q13.1   Ensembl cytogenetic band:  13q13.3   HGNC cytogenetic band: 13q13.1

EXOSC8 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
EXOSC8 gene location

GeneLoc information about chromosome 13         GeneLoc Exon Structure

GeneLoc location for GC13P037572:  view genomic region     (about GC identifiers)

Start:
37,572,953 bp from pter      End:
37,583,751 bp from pter
Size:
10,799 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: EXOS8_HUMAN, Q96B26 (See protein sequence)
Recommended Name: Exosome complex component RRP43  
Size: 276 amino acids; 30040 Da
Subunit: Component of the RNA exosome complex. Specifically part of the catalytically inactive RNA exosome core
(Exo-9) complex which is believed to associate with catalytic subunits EXOSC10, and DIS3 or DIS3L in cytoplasmic-
and nuclear-specific RNA exosome complex forms. Exo-9 is formed by a hexameric ring of RNase PH domain-containing
subunits specifically containing the heterodimers EXOSC4-EXOSC9, EXOSC5-EXOSC8 and EXOSC6-EXOSC7, and peripheral
S1 domain-containing components EXOSC1, EXOSC2 and EXOSC3 located on the top of the ring structure. Binds outer
membrane protein opap from Neisseria gonorrhoeae
Caution: The six exosome core subunits containing a RNase PH-domain are not phosphorolytically active
Sequence caution: Sequence=CAI14013.1; Type=Erroneous gene model prediction; Sequence=EAX08581.1; Type=Erroneous
gene model prediction;
1 PDB 3D structure from and Proteopedia for EXOSC8:
2NN6 (3D)    
Secondary accessions: O43480 Q5TBA5

Explore the universe of human proteins at neXtProt for EXOSC8: NX_Q96B26

Explore proteomics data for EXOSC8 at MOPED


See EXOSC8 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

REFSEQ proteins: NP_852480.1  
ENSEMBL proteins: 
 ENSP00000374354   ENSP00000239893   ENSP00000419203  
Reactome Protein details: Q96B26

EXOSC8 Human Recombinant Protein Products:

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Novus Biologicals EXOSC8 Lysate
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EXOSC8 Antibody Products:

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LSBio Antibodies in human, mouse, rat for EXOSC8

EXOSC8 Assay Products:

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Cloud-Clone Corp. ELISAs for EXOSC8
Cloud-Clone Corp. CLIAs for EXOSC8


(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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4 InterPro protein domains:
 IPR015847 ExoRNase_PH_dom2
 IPR001247 ExoRNase_PH_dom1
 IPR020568 Ribosomal_S5_D2-typ_fold
 IPR027408 PNPase/RNase_PH_dom

Graphical View of Domain Structure for InterPro Entry Q96B26

ProtoNet protein and cluster: Q96B26

UniProtKB/Swiss-Prot: EXOS8_HUMAN, Q96B26
Similarity: Belongs to the RNase PH family


EXOSC8 for domains           About GeneDecksing


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Molecular Function:

     UniProtKB/Swiss-Prot Summary: EXOS8_HUMAN, Q96B26
Function: Non-catalytic component of the RNA exosome complex which has 3'->5' exoribonuclease activity and
participates in a multitude of cellular RNA processing and degradation events. In the nucleus, the RNA exosome
complex is involved in proper maturation of stable RNA species such as rRNA, snRNA and snoRNA, in the elimination
of RNA processing by-products and non-coding 'pervasive' transcripts, such as antisense RNA species and
promoter-upstream transcripts (PROMPTs), and of mRNAs with processing defects, thereby limiting or excluding
their export to the cytoplasm. The RNA exosome may be involved in Ig class switch recombination (CSR) and/or Ig
variable region somatic hypermutation (SHM) by targeting AICDA deamination activity to transcribed dsDNA
substrates. In the cytoplasm, the RNA exosome complex is involved in general mRNA turnover and specifically
degrades inherently unstable mRNAs containing AU-rich elements (AREs) within their 3' untranslated regions, and
in RNA surveillance pathways, preventing translation of aberrant mRNAs. It seems to be involved in degradation of
histone mRNA. The catalytic inactive RNA exosome core complex of 9 subunits (Exo-9) is proposed to play a pivotal
role in the binding and presentation of RNA for ribonucleolysis, and to serve as a scaffold for the association
with catalytic subunits and accessory proteins or complexes. EXOSC8 binds to ARE-containing RNAs

     Gene Ontology (GO): 3 molecular function terms:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0004532NOT exoribonuclease activity IDA17174896
GO:0005515protein binding IPI12419256
GO:0017091AU-rich element binding IDA16912217
     
EXOSC8 for ontologies           About GeneDecksing


Phenotypes:
     2 GenomeRNAi human phenotypes for EXOSC8:
 Small cells  Synthetic lethal with Ras 

     1 MGI phenotypic allele for Exosc8 (no phenotypes)

EXOSC8 for phenotypes           About GeneDecksing

Animal Models:
     MGI mouse knock-out Exosc8tm1(KOMP)Vlcg for EXOSC8

   inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for EXOSC8
   inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for EXOSC8

   genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for EXOSC8
   genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for EXOSC8

miRNA
Products:
    
miRTarBase miRNAs that target EXOSC8:
hsa-mir-24-3p (MIRT030408)

Block miRNA regulation of human, mouse, rat EXOSC8 using miScript Target Protectors
3 qRT-PCR Assays for microRNAs that regulate EXOSC8:
hsa-miR-7-2* hsa-miR-7-1* hsa-miR-16-1*
Browse SwitchGear 3'UTR luciferase reporter plasmids
Inhib. RNA
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OriGene RNAi products in human, mouse, rat for EXOSC8
Predesigned siRNA for gene silencing in human, mouse, rat EXOSC8

Gene Editing
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OriGene ORF clones in mouse, rat for EXOSC8
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
GenScript: all cDNA clones in your preferred vector: EXOSC8 (NM_181503)
Browse Sino Biological Human cDNA Clones
DNA2.0 Custom Codon Optimized Gene Synthesis Service for EXOSC8
Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat EXOSC8

Cell Line
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GenScript Custom overexpressing Cell Line Services for EXOSC8
Browse ESI BIO Cell Lines and PureStem Progenitors for EXOSC8 
In Situ Assay
Products:
   

 
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for EXOSC8


(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Subcellular locations from UniProtKB/Swiss-Prot
EXOS8_HUMAN, Q96B26: Cytoplasm. Nucleus. Nucleus, nucleolus (By similarity)
Subcellular locations from COMPARTMENTS: 

CompartmentConfidence
nucleus5
cytosol4
cytoskeleton3
endoplasmic reticulum1
extracellular1
mitochondrion1

Gene Ontology (GO): 5 cellular component terms:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0000178exosome (RNase complex) IDA--
GO:0005634nucleus IDA17545563
GO:0005730nucleolus IEA--
GO:0005737cytoplasm IDA17545563
GO:0005829cytosol TAS--

EXOSC8 for ontologies           About GeneDecksing


(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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SuperPaths for EXOSC8 About   (see all 7)  
See pathways by source

SuperPathContained pathways About
1Deadenylation-dependent mRNA decay
Deadenylation-dependent mRNA decay0.48
mRNA Decay by 3 to 5' Exoribonuclease0.00
RNA degradation0.48
2CDK-mediated phosphorylation and removal of Cdc6
Regulation of mRNA Stability by Proteins that Bind AU-rich Elements0.62
Destabilization of mRNA by KSRP0.00
Destabilization of mRNA by Butyrate Response Factor 1 (BRF1)0.00
Destabilization of mRNA by Tristetraprolin (TTP)0.00
3PERK regulated gene expression
PERK regulated gene expression0.90
Activation of Genes by ATF40.90
4Unfolded Protein Response
Unfolded Protein Response0.61
5Gene Expression
Gene Expression0.40

Pathways by source                                                                                                                                                                 See SuperPaths
Show all pathways


1 GeneGo (Thomson Reuters) Pathway for EXOSC8
    ATP/ITP metabolism

5 Reactome Pathways for EXOSC8
    Tristetraprolin (TTP) destabilizes mRNA
Butyrate Response Factor 1 (BRF1) destabilizes mRNA
KSRP destabilizes mRNA
mRNA decay by 3' to 5' exoribonuclease
ATF4 activates genes


1 Kegg Pathway  (Kegg details for EXOSC8):
    RNA degradation


EXOSC8 for pathways           About GeneDecksing

    Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for EXOSC8
Interactions:

    GeneGlobe Interaction Network for EXOSC8

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

Selected Interacting proteins for EXOSC8 (Q96B261, 2, 3 ENSP000003743544) via UniProtKB, MINT, STRING, and/or I2D (see all 105)
InteractantInteraction Details
GeneCardExternal ID(s)
EXOSC5Q9NQT41, 2, 3, ENSP000002212334EBI-371922,EBI-371876 MINT-7993644 MINT-7993837 MINT-7988296 MINT-7993717 I2D: score=4 STRING: ENSP00000221233
EXOSC1Q9Y3B22, 3, ENSP000003599394MINT-7993644 MINT-7993893 MINT-7993837 MINT-7988296 MINT-7993717 I2D: score=2 STRING: ENSP00000359939
EXOSC7Q150242, 3, ENSP000002655644MINT-7993644 MINT-7993893 MINT-7993837 MINT-7988296 MINT-7993717 I2D: score=2 STRING: ENSP00000265564
EXOSC9Q062652, 3, ENSP000003689844MINT-7993644 MINT-7993893 MINT-7993837 MINT-7988296 MINT-7993717 I2D: score=1 STRING: ENSP00000368984
EXOSC6Q5RKV62, 3, ENSP000003985974MINT-7993644 MINT-7993837 MINT-7988296 I2D: score=3 STRING: ENSP00000398597
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Gene Ontology (GO): Selected biological process terms (see all 7):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0000288nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay TAS--
GO:0006364rRNA processing IEA--
GO:0008150biological_process ND--
GO:0010467gene expression TAS--
GO:0016070RNA metabolic process TAS--

EXOSC8 for ontologies           About GeneDecksing



(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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Browse Small Molecules at EMD Millipore
   Browse drugs & compounds from Enzo Life Sciences
  Browse compounds at ApexBio 

Browse Tocris compounds for EXOSC8 (EXOS8)



(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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REFSEQ mRNAs for EXOSC8 gene: 
NM_181503.2  

Unigene Cluster for EXOSC8:

Exosome component 8
Hs.294041  [show with all ESTs]
Unigene Representative Sequence: AL050353
11 Ensembl transcripts including schematic representations, and UCSC links where relevant:
ENST00000489088 ENST00000389704(uc001uvz.2 uc001uwa.3) ENST00000239893
ENST00000474661 ENST00000490537 ENST00000488108 ENST00000464235 ENST00000488779
ENST00000470423 ENST00000495092 ENST00000481013
miRNA
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Block miRNA regulation of human, mouse, rat EXOSC8 using miScript Target Protectors
3 qRT-PCR Assays for microRNAs that regulate EXOSC8:
hsa-miR-7-2* hsa-miR-7-1* hsa-miR-16-1*
Browse SwitchGear 3'UTR luciferase reporter plasmids
Inhib. RNA
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Predesigned siRNA for gene silencing in human, mouse, rat EXOSC8
Clone
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OriGene ORF clones in mouse, rat for EXOSC8
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
GenScript: all cDNA clones in your preferred vector: EXOSC8 (NM_181503)
DNA2.0 Custom Codon Optimized Gene Synthesis Service for EXOSC8
Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat EXOSC8
Primer
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OriGene qPCR primer pairs and template standards for EXOSC8
OriGene qSTAR qPCR primer pairs in human, mouse for EXOSC8
Pre-validated RT2 qPCR Primer Assay in human, mouse, rat EXOSC8
  QuantiTect SYBR Green Assays in human, mouse, rat EXOSC8
  QuantiFast Probe-based Assays in human, mouse, rat EXOSC8

Additional mRNA sequence: 

AF025438.1 AL050353.1 BC020773.1 

15 DOTS entries:

DT.95172126  DT.100039725  DT.447707  DT.100828891  DT.120794375  DT.91985875  DT.100828863  DT.86998283 
DT.92454817  DT.95172113  DT.95200281  DT.100828887  DT.95172124  DT.100703520  DT.433386 

Selected AceView cDNA sequences (see all 302):

AA992256 BE349061 BM979924 BU687776 AI538205 CN479068 CD677122 CB110833 
BM703462 BX641448 AI753758 CR602904 AA451907 AA913049 BM991947 CD673582 
CA314262 AI678339 BU729389 BQ573928 AA236789 AA680352 AA723980 AA995467 

GeneLoc Exon Structure

Selected Alternative Splicing Database (ASD) splice patterns (SP) for EXOSC8 (see all 6)    About this scheme

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6a · 6b · 6c ^ 7a · 7b · 7c ^ 8 ^ 9 ^ 10 ^ 11 ^ 12
SP1:                                -     -     -           -                                             
SP2:                                                                                                      
SP3:                                                        -     -                                       
SP4:                                                                                                      
SP5:        -     -                                                                                       


ECgene alternative splicing isoforms for EXOSC8

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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EXOSC8 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: --
EXOSC8 Expression
About this image


EXOSC8 expression in embryonic tissues and stem cells    About this table
Data from LifeMap, the Embryonic Development and Stem Cells Database
 selected tissues (see all 2) fully expand
 
 Ovary (Reproductive System)
         Primary Oocyte Primary Follicle
 
 Gonad
         Primary Oocyte Primary Follicle
EXOSC8 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

EXOSC8 Protein Expression

SOURCE GeneReport for Unigene cluster: Hs.294041
    Custom PCR Arrays for EXOSC8
Primer
Products:
OriGene qPCR primer pairs and template standards for EXOSC8
OriGene qSTAR qPCR primer pairs in human, mouse for EXOSC8
Pre-validated RT2 qPCR Primer Assay in human, mouse, rat EXOSC8
QuantiTect SYBR Green Assays in human, mouse, rat EXOSC8
QuantiFast Probe-based Assays in human, mouse, rat EXOSC8
In Situ
Assay Products:
 

 
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for EXOSC8

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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This gene was present in the common ancestor of eukaryotes.

Orthologs for EXOSC8 gene from Selected species (see all 20)    About this table
Organism Taxonomic
classification
Gene Description Human
Similarity
Orthology
Type
Details
mouse
(Mus musculus)
Mammalia Exosc81 , 5 exosome component 81, 5 87.56(n)1
92.03(a)1
  3 (25.60 cM)5
696391  NM_001163570.11  NP_001157042.11 
 547286785 
chicken
(Gallus gallus)
Aves EXOSC81 exosome component 8 78.74(n)
82.97(a)
  100858560  XM_003640577.2  XP_003640625.1 
lizard
(Anolis carolinensis)
Reptilia EXOSC86
exosome component 8
78(a)
1 ↔ 1
2(82531360-82552642)
African clawed frog
(Xenopus laevis)
Amphibia MGC528472 hypothetical protein MGC52847 75.02(n)    BC041271.1 
zebrafish
(Danio rerio)
Actinopterygii exosc81 exosome component 8 69.46(n)
70.8(a)
  323016  NM_001002865.1  NP_001002865.1 
mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP0124021 AgaP_AGAP012402 53.88(n)
48.12(a)
  1280314  XM_320154.3  XP_320154.3 
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes RRP456
Exosome non-catalytic core component; involved in ...
24(a)
1 → many
IV(1020747-1021664) YDR280W
thale cress
(Arabidopsis thaliana)
eudicotyledons AT1G600801 AT1G60080 49.18(n)
37.74(a)
  842303  NM_104700.4  NP_176216.1 
rice
(Oryza sativa)
Liliopsida Os11g03113001 Os11g0311300 46.21(n)
34.85(a)
  4350355  NM_001074290.1  NP_001067758.1 


ENSEMBL Gene Tree for EXOSC8 (if available)
TreeFam Gene Tree for EXOSC8 (if available)

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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Paralogs for EXOSC8 gene
EXOSC92  EXOSC72  
3 SIMAP similar genes for EXOSC8 using alignment to 3 protein entries:     EXOS8_HUMAN (see all proteins):
DKFZp564C0482    EXOSC9    EXOSC7

EXOSC8 for paralogs           About GeneDecksing


1 Pseudogenes.org Pseudogene for EXOSC8
PGOHUM00000243177


(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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Selected SNPs for EXOSC8 (see all 160)    About this table    
Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance
Chr 13 posSequence#AA
Chg
TypeMore#Allele
freq
PopTotal
sample
More
----------
rs1901459311,2
--37575529(+) CGACAA/GAGTGA 1 -- int10--------
rs735417101,2
C,F--37575550(+) GAATCA/CATCAA 1 -- int13Minor allele frequency- C:0.09WA 122
rs1500450011,2
--37575551(+) AATCAA/GTCAAT 1 -- int10--------
rs1158996831,2
F--37575558(+) CAATCA/TAGATT 1 -- int11Minor allele frequency- T:0.03WA 118
rs73293141,2
C,H--37575766(+) agacaT/Cgatat 1 -- int110Minor allele frequency- C:0.14NA WA EA 372
rs1928429461,2
--37575972(+) CTTACA/GGTCAT 1 -- int10--------
rs1114310191,2
C,F--37576073(+) TGATCA/CCTAGA 1 -- int12Minor allele frequency- C:0.05CSA WA 123
rs1840319991,2
--37576134(+) TTCAGA/GGCAAG 1 -- int10--------
rs1401927251,2
--37576212(+) ATCTTA/CTAATC 1 -- int10--------
rs1438552451,2
C--37576229(+) GGCAGA/GGTTAA 1 -- int10--------

HapMap Linkage Disequilibrium report for EXOSC8 (37572953 - 37583751 bp)

Structural Variations
     Database of Genomic Variants (DGV) 1 variation for EXOSC8:    About this table    
Variant IDTypeSubtypePubMed ID
nsv522336CNV Gain19592680

Site Specific Mutation Identification with PCR Assays
SeqTarget long-range PCR primers for resequencing EXOSC8
DNA2.0 Custom Variant and Variant Library Synthesis for EXOSC8

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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OMIM gene information: 606019    OMIM disorders: --

6 diseases for EXOSC8:    
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cryptococcosis    hemophagocytic lymphohistiocytosis    polymyositis    scleroderma
malaria    breast cancer

1 disease from the University of Copenhagen DISEASES database for EXOSC8:
Hemophagocytic lymphohistiocytosis

EXOSC8 for disorders           About GeneDecksing


Export disorders for EXOSC8 gene to outside databases

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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PubMed articles for EXOSC8 gene, integrated from 10 sources (see all 31):
(articles sorted by number of sources associating them with EXOSC8)
    Utopia: connect your pdf to the dynamic
world of online information

  1. Using the yeast two-hybrid system to identify human epithelial cell proteins that bind gonococcal Opa proteins: intracellular gonococci bind pyruvate kinase via their Opa proteins and require host pyruvate for growth. (PubMed id 9466265)1, 2, 3 Williams J.M.... Rest R.F. (Mol. Microbiol. 1998)
  2. A protein subunit of human RNase P, Rpp14, and its interacting partner, OIP2, have 3'--&gt;5' exoribonuclease activity. (PubMed id 11929972)1, 3, 9 Jiang T. and Altman S. (Proc. Natl. Acad. Sci. U.S.A. 2002)
  3. Dis3-like 1: a novel exoribonuclease associated with the human exosome. (PubMed id 20531389)1, 2 Staals R.H.... Pruijn G.J. (EMBO J. 2010)
  4. Human cell growth requires a functional cytoplasmic exosome, which is involved in various mRNA decay pathways. (PubMed id 17545563)1, 2 van Dijk E.L.... Pruijn G.J. (RNA 2007)
  5. Reconstitution, activities, and structure of the eukaryotic RNA exosome. (PubMed id 17174896)1, 2 Liu Q.... Lima C.D. (Cell 2006)
  6. Sequence-specific RNA binding mediated by the RNase PH domain of components of the exosome. (PubMed id 16912217)1, 2 Anderson J.R.... Wilusz J. (RNA 2006)
  7. A protein interaction framework for human mRNA degradation. (PubMed id 15231747)1, 2 Lehner B. and Sanderson C.M. (Genome Res. 2004)
  8. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
  9. Protein-protein interactions between human exosome components support the assembly of RNase PH-type subunits into a six-membered PNPase-like ring. (PubMed id 12419256)1, 2 Raijmakers R.... Pruijn G.J.M. (J. Mol. Biol. 2002)
  10. AU binding proteins recruit the exosome to degrade ARE-containing mRNAs. (PubMed id 11719186)1, 2 Chen C.-Y.... Karin M. (Cell 2001)

(in PubMed, OMIM, and NCBI Bookshelf)
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 ANDOR
Aliases
Free Text  

  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 11340 HGNC: 17035 AceView: EXOSC8 Ensembl:ENSG00000120699 euGenes: HUgn11340
ECgene: EXOSC8 Kegg: 11340 H-InvDB: EXOSC8

(According to HUGE)
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  --

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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NameDescription
PharmGKB entry for EXOSC8 Pharmacogenomics, SNPs, Pathways

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
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Patent Information for EXOSC8 gene:
Search GeneIP for patents involving EXOSC8

GeneCards and IP:
Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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