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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

EXOSC8 Gene

protein-coding   GIFtS: 59
GCID: GC13P037572

Exosome Component 8

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Exosome Component 81 2 3     p92 3
OIP22 3 5     CIP32
RRP432 3 5     EAP22
CBP-Interacting Protein 31 2     RP11-421P11.32
Opa Interacting Protein 21 2     Rrp43p2
Opa-Interacting Protein 22 3     bA421P11.32
Ribosomal RNA-Processing Protein 432 3     Exosome Complex Component RRP432
OIP-22 3     Exosome Complex Exonuclease RRP432

External Ids:    HGNC: 170351   Entrez Gene: 113402   Ensembl: ENSG000001206997   OMIM: 6060195   UniProtKB: Q96B263   

Export aliases for EXOSC8 gene to outside databases

Previous GC identifers: GC13P035373 GC13P036472 GC13P018386


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for EXOSC8 Gene:
This gene encodes a 3'-5' exoribonuclease that specifically interacts with mRNAs containing AU-rich elements. The
encoded protein is part of the exosome complex that is important for the degradation of numerous RNA species. A
pseudogene of this gene is found on chromosome 6. (provided by RefSeq, Mar 2009)

GeneCards Summary for EXOSC8 Gene: 
EXOSC8 (exosome component 8) is a protein-coding gene. Diseases associated with EXOSC8 include cryptococcosis, and male breast cancer, and among its related super-pathways are RNA degradation and Destabilization of mRNA by Tristetraprolin (TTP). GO annotations related to this gene include exoribonuclease activity and AU-rich element binding. An important paralog of this gene is EXOSC9.

UniProtKB/Swiss-Prot: EXOS8_HUMAN, Q96B26
Function: Non-catalytic component of the RNA exosome complex which has 3'->5' exoribonuclease activity and
participates in a multitude of cellular RNA processing and degradation events. In the nucleus, the RNA exosome
complex is involved in proper maturation of stable RNA species such as rRNA, snRNA and snoRNA, in the elimination
of RNA processing by-products and non-coding 'pervasive' transcripts, such as antisense RNA species and
promoter-upstream transcripts (PROMPTs), and of mRNAs with processing defects, thereby limiting or excluding
their export to the cytoplasm. The RNA exosome may be involved in Ig class switch recombination (CSR) and/or Ig
variable region somatic hypermutation (SHM) by targeting AICDA deamination activity to transcribed dsDNA
substrates. In the cytoplasm, the RNA exosome complex is involved in general mRNA turnover and specifically
degrades inherently unstable mRNAs containing AU-rich elements (AREs) within their 3' untranslated regions, and
in RNA surveillance pathways, preventing translation of aberrant mRNAs. It seems to be involved in degradation of
histone mRNA. The catalytic inactive RNA exosome core complex of 9 subunits (Exo-9) is proposed to play a pivotal
role in the binding and presentation of RNA for ribonucleolysis, and to serve as a scaffold for the association
with catalytic subunits and accessory proteins or complexes. EXOSC8 binds to ARE-containing RNAs

Gene Wiki entry for EXOSC8 (Exosome component 8) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000013.10  NC_018924.2  NT_024524.14  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the EXOSC8 gene promoter:
         GR   GR-beta   Lmo2   Tal-1beta   MEF-2A   GR-alpha   aMEF-2   ITF-2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidEXOSC8 promoter sequence
   Search SABiosciences Chromatin IP Primers for EXOSC8

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat EXOSC8


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 13q13.1   Ensembl cytogenetic band:  13q13.3   HGNC cytogenetic band: 13q13.1

EXOSC8 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
EXOSC8 gene location

GeneLoc information about chromosome 13         GeneLoc Exon Structure

GeneLoc location for GC13P037572:  view genomic region     (about GC identifiers)

Start:
37,572,953 bp from pter      End:
37,583,751 bp from pter
Size:
10,799 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: EXOS8_HUMAN, Q96B26 (See protein sequence)
Recommended Name: Exosome complex component RRP43  
Size: 276 amino acids; 30040 Da
Subunit: Component of the RNA exosome complex. Specifically part of the catalytically inactive RNA exosome core
(Exo-9) complex which is believed to associate with catalytic subunits EXOSC10, and DIS3 or DIS3L in cytoplasmic-
and nuclear-specific RNA exosome complex forms. Exo-9 is formed by a hexameric ring of RNase PH domain-containing
subunits specifically containing the heterodimers EXOSC4-EXOSC9, EXOSC5-EXOSC8 and EXOSC6-EXOSC7, and peripheral
S1 domain-containing components EXOSC1, EXOSC2 and EXOSC3 located on the top of the ring structure. Binds outer
membrane protein opap from Neisseria gonorrhoeae
Subcellular location: Cytoplasm. Nucleus. Nucleus, nucleolus (By similarity)
Caution: The six exosome core subunits containing a RNase PH-domain are not phosphorolytically active
Sequence caution: Sequence=CAI14013.1; Type=Erroneous gene model prediction; Sequence=EAX08581.1; Type=Erroneous
gene model prediction;
1 PDB 3D structure from and Proteopedia for EXOSC8:
2NN6 (3D)    
Secondary accessions: O43480 Q5TBA5

Explore the universe of human proteins at neXtProt for EXOSC8: NX_Q96B26

Explore proteomics data for EXOSC8 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q96B26

  • EXOSC8 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    EXOSC8 Protein Expression
    REFSEQ proteins: NP_852480.1  
    ENSEMBL proteins: 
     ENSP00000374354   ENSP00000239893   ENSP00000419203  
    Reactome Protein details: Q96B26
    Human Recombinant Protein Products for EXOSC8: 
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    OriGene MassSpec for EXOSC8 
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    GenScript Custom Purified and Recombinant Proteins Services for EXOSC8
    Novus Biologicals EXOSC8 Proteins
    Novus Biologicals EXOSC8 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for EXOSC8 

    Gene Ontology (GO): 5 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000178exosome (RNase complex) IDA--
    GO:0005634nucleus IDA17545563
    GO:0005730nucleolus IEA--
    GO:0005737cytoplasm IDA17545563
    GO:0005829cytosol TAS--

    EXOSC8 for ontologies           About GeneDecksing



    EXOSC8 Antibody Products: 
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    Abcam antibodies for EXOSC8
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    LSBio Antibodies in human, mouse, rat for EXOSC8 

    Assay Products for EXOSC8: 
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    GenScript Custom Assay Services for EXOSC8
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for EXOSC8 
    Cloud-Clone Corp. CLIAs for EXOSC8


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    4 InterPro protein domains:
     IPR015847 ExoRNase_PH_dom2
     IPR001247 ExoRNase_PH_dom1
     IPR020568 Ribosomal_S5_D2-typ_fold
     IPR027408 PNPase/RNase_PH_dom

    Graphical View of Domain Structure for InterPro Entry Q96B26

    ProtoNet protein and cluster: Q96B26

    UniProtKB/Swiss-Prot: EXOS8_HUMAN, Q96B26
    Similarity: Belongs to the RNase PH family


    EXOSC8 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: EXOS8_HUMAN, Q96B26
    Function: Non-catalytic component of the RNA exosome complex which has 3'->5' exoribonuclease activity and
    participates in a multitude of cellular RNA processing and degradation events. In the nucleus, the RNA exosome
    complex is involved in proper maturation of stable RNA species such as rRNA, snRNA and snoRNA, in the elimination
    of RNA processing by-products and non-coding 'pervasive' transcripts, such as antisense RNA species and
    promoter-upstream transcripts (PROMPTs), and of mRNAs with processing defects, thereby limiting or excluding
    their export to the cytoplasm. The RNA exosome may be involved in Ig class switch recombination (CSR) and/or Ig
    variable region somatic hypermutation (SHM) by targeting AICDA deamination activity to transcribed dsDNA
    substrates. In the cytoplasm, the RNA exosome complex is involved in general mRNA turnover and specifically
    degrades inherently unstable mRNAs containing AU-rich elements (AREs) within their 3' untranslated regions, and
    in RNA surveillance pathways, preventing translation of aberrant mRNAs. It seems to be involved in degradation of
    histone mRNA. The catalytic inactive RNA exosome core complex of 9 subunits (Exo-9) is proposed to play a pivotal
    role in the binding and presentation of RNA for ribonucleolysis, and to serve as a scaffold for the association
    with catalytic subunits and accessory proteins or complexes. EXOSC8 binds to ARE-containing RNAs

         Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004532NOT exoribonuclease activity IDA17174896
    GO:0005515protein binding IPI12419256
    GO:0017091AU-rich element binding IDA16912217
         
    EXOSC8 for ontologies           About GeneDecksing


    Phenotypes:
         2 GenomeRNAi human phenotypes for EXOSC8:
     Small cells  Synthetic lethal with Ras 

         1 MGI phenotypic allele for Exosc8 (no phenotypes)

    EXOSC8 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Exosc8tm1(KOMP)Vlcg for EXOSC8

       inGenious Targeting Laboratory - Custom generated mouse model solutions for EXOSC8 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for EXOSC8

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for EXOSC8 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for EXOSC8 

    miRNA
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    hsa-miR-7-2* hsa-miR-7-1* hsa-miR-16-1*
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
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    Gene Editing
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    Clone
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    GenScript: all cDNA clones in your preferred vector: EXOSC8 (NM_181503)
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                         Customized lentivirus expression plasmids for stable overexpression of EXOSC8 

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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for EXOSC8


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for EXOSC8 About   (see all 6)                                                                                              See pathways by source

    SuperPathContained pathways About
    1Deadenylation-dependent mRNA decay
    Deadenylation-dependent mRNA decay0.49
    RNA degradation0.49
    2Destabilization of mRNA by Tristetraprolin (TTP)
    Destabilization of mRNA by Tristetraprolin (TTP)0.79
    mRNA Decay by 3' to 5' Exoribonuclease0.56
    Destabilization of mRNA by Butyrate Response Factor 1 (BRF1)0.79
    Destabilization of mRNA by KSRP0.56
    3Metabolism of mRNA
    Metabolism of mRNA0.92
    Metabolism of RNA0.92
    4CDK-mediated phosphorylation and removal of Cdc6
    Regulation of mRNA Stability by Proteins that Bind AU-rich Elements0.63
    5Generic Transcription Pathway
    Gene Expression0.47

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 EMD Millipore Pathway for EXOSC8
        ATP/ITP metabolism


    1 GeneGo (Thomson Reuters) Pathway for EXOSC8
        ATP/ITP metabolism

    5/9        Reactome Pathways for EXOSC8 (see all 9)
        Regulation of mRNA Stability by Proteins that Bind AU-rich Elements
    Destabilization of mRNA by Butyrate Response Factor 1 (BRF1)
    Destabilization of mRNA by KSRP
    mRNA Decay by 3' to 5' Exoribonuclease
    Deadenylation-dependent mRNA decay


    1         Kegg Pathway  (Kegg details for EXOSC8):
        RNA degradation


    EXOSC8 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for EXOSC8

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/60 Interacting proteins for EXOSC8 (Q96B261, 2, 3 ENSP000003743544) via UniProtKB, MINT, STRING, and/or I2D (see all 60)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    EXOSC5Q9NQT41, 2, 3, ENSP000002212334EBI-371922,EBI-371876 MINT-7993644 MINT-7993837 MINT-7988296 MINT-7993717 I2D: score=4 STRING: ENSP00000221233
    EXOSC1Q9Y3B22, 3, ENSP000003599394MINT-7993644 MINT-7993893 MINT-7993837 MINT-7988296 MINT-7993717 I2D: score=2 STRING: ENSP00000359939
    EXOSC7Q150242, 3, ENSP000002655644MINT-7993644 MINT-7993893 MINT-7993837 MINT-7988296 MINT-7993717 I2D: score=2 STRING: ENSP00000265564
    EXOSC9Q062652, 3, ENSP000003689844MINT-7993644 MINT-7993893 MINT-7993837 MINT-7988296 MINT-7993717 I2D: score=1 STRING: ENSP00000368984
    EXOSC6Q5RKV62, 3, ENSP000003985974MINT-7993644 MINT-7993837 MINT-7988296 I2D: score=3 STRING: ENSP00000398597
    About this table

    Gene Ontology (GO): 5/7 biological process terms (GO ID links to tree view) (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000288nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay TAS--
    GO:0006364rRNA processing IEA--
    GO:0008150biological_process ND--
    GO:0010467gene expression TAS--
    GO:0016070RNA metabolic process TAS--

    EXOSC8 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for EXOSC8 (EXOS8)

    Search CenterWatch for drugs/clinical trials and news about EXOSC8 / EXOS8

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for EXOSC8 gene: 
    NM_181503.2  

    Unigene Cluster for EXOSC8:

    Exosome component 8
    Hs.294041  [show with all ESTs]
    Unigene Representative Sequence: AL050353
    11 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000489088 ENST00000389704(uc001uvz.2 uc001uwa.3) ENST00000239893
    ENST00000474661 ENST00000490537 ENST00000488108 ENST00000464235 ENST00000488779
    ENST00000470423 ENST00000495092 ENST00000481013
    miRNA
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat EXOSC8
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat EXOSC8

    Additional mRNA sequence: 

    AF025438.1 AL050353.1 BC020773.1 

    15 DOTS entries:

    DT.95172126  DT.100039725  DT.447707  DT.100828891  DT.120794375  DT.91985875  DT.100828863  DT.86998283 
    DT.92454817  DT.95172113  DT.95200281  DT.100828887  DT.95172124  DT.100703520  DT.433386 

    24/302 AceView cDNA sequences (see all 302):

    AI538205 CN480933 BE737906 CD673582 BM904094 CR595030 CR612849 AA451907 
    CR602904 BX641448 AA928158 AA680352 CA945228 CN479068 BX481599 BQ574798 
    AA765777 AA913049 BM741221 AA858049 BM991947 AI337332 AA916723 BU943696 

    GeneLoc Exon Structure

    5/6 Alternative Splicing Database (ASD) splice patterns (SP) for EXOSC8 (see all 6)    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6a · 6b · 6c ^ 7a · 7b · 7c ^ 8 ^ 9 ^ 10 ^ 11 ^ 12
    SP1:                                -     -     -           -                                             
    SP2:                                                                                                      
    SP3:                                                        -     -                                       
    SP4:                                                                                                      
    SP5:        -     -                                                                                       


    ECgene alternative splicing isoforms for EXOSC8

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    EXOSC8 expression in normal human tissues (normalized intensities)      EXOSC8 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    EXOSC8 Expression
    About this image


    EXOSC8 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/2 selected tissues (see all 2) fully expand
     
     Ovary (Reproductive System)
             Primary Oocyte Primary Follicle
     
     Gonad
             Primary Oocyte Primary Follicle

    See EXOSC8 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for EXOSC8

    SOURCE GeneReport for Unigene cluster: Hs.294041
        SABiosciences Custom PCR Arrays for EXOSC8
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    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat EXOSC8
    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for EXOSC8 gene from 9/20 species (see all 20)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Exosc81 , 5 exosome component 81, 5 87.56(n)1
    92.03(a)1
      3 (25.60 cM)5
    696391  NM_001163570.11  NP_001157042.11 
     547286785 
    chicken
    (Gallus gallus)
    Aves LOC1008585601 exosome complex component RRP43-like 78.74(n)
    82.97(a)
      100858560  XM_003640577.1  XP_003640625.1 
    lizard
    (Anolis carolinensis)
    Reptilia EXOSC86
    exosome component 8
    78(a)
    1 ↔ 1
    2(82531360-82552642)
    African clawed frog
    (Xenopus laevis)
    Amphibia MGC528472 hypothetical protein MGC52847 75.02(n)    BC041271.1 
    zebrafish
    (Danio rerio)
    Actinopterygii exosc81 exosome component 8 69.46(n)
    70.8(a)
      323016  NM_001002865.1  NP_001002865.1 
    mosquito
    (Anopheles gambiae)
    Insecta AgaP_AGAP0124021 AGAP012402-PA 53.72(n)
    48.08(a)
      1280314  XM_320154.3  XP_320154.3 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes RRP456
    Exosome non-catalytic core component; involved in ...
    24(a)
    1 → many
    IV(1020747-1021664)
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons AT1G600801 3' exoribonuclease domain 1-containing protein 49.24(n)
    37.88(a)
      842303  NM_104700.4  NP_176216.1 
    rice
    (Oryza sativa)
    Liliopsida Os11g03113001 hypothetical protein 46.21(n)
    34.85(a)
      4350355  NM_001074290.1  NP_001067758.1 


    ENSEMBL Gene Tree for EXOSC8 (if available)
    TreeFam Gene Tree for EXOSC8 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for EXOSC8 gene
    EXOSC92  EXOSC72  
    3 SIMAP similar genes for EXOSC8 using alignment to 3 protein entries:     EXOS8_HUMAN (see all proteins):
    DKFZp564C0482    EXOSC9    EXOSC7

    EXOSC8 for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for EXOSC8
    PGOHUM00000243177


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/160 SNPs in EXOSC8 are shown (see all 160)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 13 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1901459311,2
    --37575529(+) CGACAA/GAGTGA 1 -- int10--------
    rs735417101,2
    C,F--37575550(+) GAATCA/CATCAA 1 -- int13Minor allele frequency- C:0.09WA 122
    rs1500450011,2
    --37575551(+) AATCAA/GTCAAT 1 -- int10--------
    rs1158996831,2
    F--37575558(+) CAATCA/TAGATT 1 -- int11Minor allele frequency- T:0.03WA 118
    rs73293141,2
    C,H--37575766(+) agacaT/Cgatat 1 -- int110Minor allele frequency- C:0.14NA WA EA 372
    rs1928429461,2
    --37575972(+) CTTACA/GGTCAT 1 -- int10--------
    rs1114310191,2
    C,F--37576073(+) TGATCA/CCTAGA 1 -- int12Minor allele frequency- C:0.05CSA WA 123
    rs1840319991,2
    --37576134(+) TTCAGA/GGCAAG 1 -- int10--------
    rs1401927251,2
    --37576212(+) ATCTTA/CTAATC 1 -- int10--------
    rs1438552451,2
    C--37576229(+) GGCAGA/GGTTAA 1 -- int10--------

    HapMap Linkage Disequilibrium report for EXOSC8 (37572953 - 37583751 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for EXOSC8:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv522336CNV Gain19592680

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 606019    OMIM disorders: --

    5 diseases for EXOSC8:    About MalaCards
    cryptococcosis    male breast cancer    polymyositis    scleroderma
    breast cancer

    1 disease from the University of Copenhagen DISEASES database for EXOSC8:
    Hemophagocytic lymphohistiocytosis

    EXOSC8 for disorders           About GeneDecksing


    Export disorders for EXOSC8 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for EXOSC8 gene, integrated from 9 sources (see all 30):
    (articles sorted by number of sources associating them with EXOSC8)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Using the yeast two-hybrid system to identify human epithelial cell proteins that bind gonococcal Opa proteins: intracellular gonococci bind pyruvate kinase via their Opa proteins and require host pyruvate for growth. (PubMed id 9466265)1, 2, 3 Williams J.M.... Rest R.F. (1998)
    2. A protein subunit of human RNase P, Rpp14, and its interacting partner, OIP2, have 3'-->5' exoribonuclease activity. (PubMed id 11929972)1, 3, 9 Jiang T. and Altman S. (2002)
    3. Dis3-like 1: a novel exoribonuclease associated with the human exosome. (PubMed id 20531389)1, 2 Staals R.H....Pruijn G.J. (2010)
    4. Human cell growth requires a functional cytoplasmic exosome, which is involved in various mRNA decay pathways. (PubMed id 17545563)1, 2 van Dijk E.L....Pruijn G.J. (2007)
    5. Reconstitution, activities, and structure of the eukaryotic RNA exosome. (PubMed id 17174896)1, 2 Liu Q.... Lima C.D. (2006)
    6. Sequence-specific RNA binding mediated by the RNase PH domain of components of the exosome. (PubMed id 16912217)1, 2 Anderson J.R....Wilusz J. (2006)
    7. A protein interaction framework for human mRNA degradation. (PubMed id 15231747)1, 2 Lehner B. and Sanderson C.M. (2004)
    8. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    9. Protein-protein interactions between human exosome components support the assembly of RNase PH-type subunits into a six-membered PNPase-like ring. (PubMed id 12419256)1, 2 Raijmakers R.... Pruijn G.J.M. (2002)
    10. AU binding proteins recruit the exosome to degrade ARE-containing mRNAs. (PubMed id 11719186)1, 2 Chen C.-Y.... Karin M. (2001)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 11340 HGNC: 17035 AceView: EXOSC8 Ensembl:ENSG00000120699 euGenes: HUgn11340
    ECgene: EXOSC8 Kegg: 11340 H-InvDB: EXOSC8

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for EXOSC8 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for EXOSC8 gene:
    Search GeneIP for patents involving EXOSC8

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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