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EXOSC7 Gene

protein-coding   GIFtS: 59
GCID: GC03P045016

Exosome Component 7

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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Exosome Component 71 2 3     Rrp42p2
RRP422 3 5     Exosome Complex Component RRP422
Ribosomal RNA-Processing Protein 422 3     Exosome Complex Exonuclease RRP422
p82 3     hRrp42p2
EAP12     KIAA01163

External Ids:    HGNC: 281121   Entrez Gene: 230162   Ensembl: ENSG000000759147   OMIM: 6064885   UniProtKB: Q150243   

Export aliases for EXOSC7 gene to outside databases

Previous GC identifers: GC03P044979 GC03P044992


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for EXOSC7 Gene:
EXOSC7 (exosome component 7) is a protein-coding gene. GO annotations related to this gene include RNA binding and exoribonuclease activity. An important paralog of this gene is EXOSC8.

UniProtKB/Swiss-Prot: EXOS7_HUMAN, Q15024
Function: Non-catalytic component of the RNA exosome complex which has 3'->5' exoribonuclease activity and
participates in a multitude of cellular RNA processing and degradation events. In the nucleus, the RNA exosome
complex is involved in proper maturation of stable RNA species such as rRNA, snRNA and snoRNA, in the elimination
of RNA processing by-products and non-coding 'pervasive' transcripts, such as antisense RNA species and
promoter-upstream transcripts (PROMPTs), and of mRNAs with processing defects, thereby limiting or excluding
their export to the cytoplasm. The RNA exosome may be involved in Ig class switch recombination (CSR) and/or Ig
variable region somatic hypermutation (SHM) by targeting AICDA deamination activity to transcribed dsDNA
substrates. In the cytoplasm, the RNA exosome complex is involved in general mRNA turnover and specifically
degrades inherently unstable mRNAs containing AU-rich elements (AREs) within their 3' untranslated regions, and
in RNA surveillance pathways, preventing translation of aberrant mRNAs. It seems to be involved in degradation of
histone mRNA. The catalytic inactive RNA exosome core complex of 9 subunits (Exo-9) is proposed to play a pivotal
role in the binding and presentation of RNA for ribonucleolysis, and to serve as a scaffold for the association
with catalytic subunits and accessory proteins or complexes

Gene Wiki entry for EXOSC7 (Exosome component 7) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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Regulatory elements:
   Regulatory transcription factor binding sites in the EXOSC7 gene promoter:
         USF1   NF-1   NF-1/L   AML1a   USF2   USF-1:USF-2   GATA-1   POU2F1   POU2F1a   USF-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidEXOSC7 promoter sequence
   Search Chromatin IP Primers for EXOSC7

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat EXOSC7


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 3p21.31   Ensembl cytogenetic band:  3p21.31   HGNC cytogenetic band: 3p21.32

EXOSC7 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
EXOSC7 gene location

GeneLoc information about chromosome 3         GeneLoc Exon Structure

GeneLoc location for GC03P045016:  view genomic region     (about GC identifiers)

Start:
45,016,733 bp from pter      End:
45,077,558 bp from pter
Size:
60,826 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: EXOS7_HUMAN, Q15024 (See protein sequence)
Recommended Name: Exosome complex component RRP42  
Size: 291 amino acids; 31821 Da
Subunit: Component of the RNA exosome complex. Specifically part of the catalytically inactive RNA exosome core
(Exo-9) complex which is believed to associate with catalytic subunits EXOSC10, and DIS3 or DIS3L in cytoplasmic-
and nuclear-specific RNA exosome complex forms. Exo-9 is formed by a hexameric ring of RNase PH domain-containing
subunits specifically containing the heterodimers EXOSC4-EXOSC9, EXOSC5-EXOSC8 and EXOSC6-EXOSC7, and peripheral
S1 domain-containing components EXOSC1, EXOSC2 and EXOSC3 located on the top of the ring structure. Interacts
with EXOSC1. Interacts with ZC3HAV1
Caution: The six exosome core subunits containing a RNase PH-domain are not phosphorolytically active
1 PDB 3D structure from and Proteopedia for EXOSC7:
2NN6 (3D)    
Secondary accessions: Q96E72

Explore the universe of human proteins at neXtProt for EXOSC7: NX_Q15024

Explore proteomics data for EXOSC7 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys205, Lys244, Lys260
  • Modification sites at PhosphoSitePlus

  • See EXOSC7 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_055819.2  
    ENSEMBL proteins: 
     ENSP00000265564  
    Reactome Protein details: Q15024

    EXOSC7 Human Recombinant Protein Products:

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    Novus Biologicals EXOSC7 Proteins
    Novus Biologicals EXOSC7 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for EXOSC7

     
    Search eBioscience for Proteins for EXOSC7 

     
    antibodies-online proteins for EXOSC7 (6 products) 

     
    antibodies-online peptides for EXOSC7

    EXOSC7 Antibody Products:

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    antibodies-online antibodies for EXOSC7 (35 products) 

    EXOSC7 Assay Products:

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    Cloud-Clone Corp. ELISAs for EXOSC7
    Cloud-Clone Corp. CLIAs for EXOSC7
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    antibodies-online kits for EXOSC7 (4 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    4 InterPro protein domains:
     IPR015847 ExoRNase_PH_dom2
     IPR001247 ExoRNase_PH_dom1
     IPR020568 Ribosomal_S5_D2-typ_fold
     IPR027408 PNPase/RNase_PH_dom

    Graphical View of Domain Structure for InterPro Entry Q15024

    ProtoNet protein and cluster: Q15024

    UniProtKB/Swiss-Prot: EXOS7_HUMAN, Q15024
    Similarity: Belongs to the RNase PH family


    Find genes that share domains with EXOSC7           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: EXOS7_HUMAN, Q15024
    Function: Non-catalytic component of the RNA exosome complex which has 3'->5' exoribonuclease activity and
    participates in a multitude of cellular RNA processing and degradation events. In the nucleus, the RNA exosome
    complex is involved in proper maturation of stable RNA species such as rRNA, snRNA and snoRNA, in the elimination
    of RNA processing by-products and non-coding 'pervasive' transcripts, such as antisense RNA species and
    promoter-upstream transcripts (PROMPTs), and of mRNAs with processing defects, thereby limiting or excluding
    their export to the cytoplasm. The RNA exosome may be involved in Ig class switch recombination (CSR) and/or Ig
    variable region somatic hypermutation (SHM) by targeting AICDA deamination activity to transcribed dsDNA
    substrates. In the cytoplasm, the RNA exosome complex is involved in general mRNA turnover and specifically
    degrades inherently unstable mRNAs containing AU-rich elements (AREs) within their 3' untranslated regions, and
    in RNA surveillance pathways, preventing translation of aberrant mRNAs. It seems to be involved in degradation of
    histone mRNA. The catalytic inactive RNA exosome core complex of 9 subunits (Exo-9) is proposed to play a pivotal
    role in the binding and presentation of RNA for ribonucleolysis, and to serve as a scaffold for the association
    with catalytic subunits and accessory proteins or complexes

         Gene Ontology (GO): 4 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:00001753'-5'-exoribonuclease activity TAS11849973
    GO:0003723RNA binding TAS11849973
    GO:0004532NOT exoribonuclease activity IDA17174896
    GO:0005515protein binding IPI11719186
         
    Find genes that share ontologies with EXOSC7           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for EXOSC7:
     Increased S DNA content 

    Animal Models:
       genOway: Develop your customized and physiologically relevant rodent model for EXOSC7

    miRNA
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    Block miRNA regulation of human, mouse, rat EXOSC7 using miScript Target Protectors
    1 qRT-PCR Assays for microRNA that regulate EXOSC7:
    hsa-miR-590-3p
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
        
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    GenScript: all cDNA clones in your preferred vector: EXOSC7 (NM_015004)
    Browse Sino Biological Human cDNA Clones
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    In Situ Assay
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    EXOS7_HUMAN, Q15024: Nucleus, nucleolus. Cytoplasm (Probable). Nucleus (Probable)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    cytosol4
    cytoskeleton1
    golgi apparatus1

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000178exosome (RNase complex) TAS11849973
    GO:0005730nucleolus IEA--
    GO:0005829cytosol TAS--

    Find genes that share ontologies with EXOSC7           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for EXOSC7 About   (see all 7)  
    See pathways by source

    SuperPathContained pathways About
    1Deadenylation-dependent mRNA decay
    Deadenylation-dependent mRNA decay0.48
    mRNA Decay by 3 to 5' Exoribonuclease0.00
    RNA degradation0.48
    2CDK-mediated phosphorylation and removal of Cdc6
    Regulation of mRNA Stability by Proteins that Bind AU-rich Elements0.62
    Destabilization of mRNA by KSRP0.00
    Destabilization of mRNA by Butyrate Response Factor 1 (BRF1)0.00
    Destabilization of mRNA by Tristetraprolin (TTP)0.00
    3PERK regulated gene expression
    PERK regulated gene expression0.90
    Activation of Genes by ATF40.90
    4Unfolded Protein Response
    Unfolded Protein Response0.61
    5Gene Expression
    Gene Expression0.40


    Find genes that share SuperPaths with EXOSC7           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 GeneGo (Thomson Reuters) Pathway for EXOSC7
        ATP/ITP metabolism

    5 Reactome Pathways for EXOSC7
        Tristetraprolin (TTP) destabilizes mRNA
    Butyrate Response Factor 1 (BRF1) destabilizes mRNA
    KSRP destabilizes mRNA
    mRNA decay by 3' to 5' exoribonuclease
    ATF4 activates genes


    1 Kegg Pathway  (Kegg details for EXOSC7):
        RNA degradation

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for EXOSC7
    Interactions:

        Search GeneGlobe Interaction Network for EXOSC7

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for EXOSC7 (Q150241, 2, 3 ENSP000002655644) via UniProtKB, MINT, STRING, and/or I2D (see all 101)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    EXOSC1Q9Y3B21, 2, 3, ENSP000003599394EBI-371841,EBI-371892 MINT-7993644 MINT-7993893 MINT-7993837 MINT-7988296 MINT-7993717 I2D: score=4 STRING: ENSP00000359939
    EXOSC9Q062652, 3, ENSP000003689844MINT-7993644 MINT-7993893 MINT-7993837 MINT-7988296 MINT-7993717 I2D: score=2 STRING: ENSP00000368984
    EXOSC5Q9NQT42, 3, ENSP000002212334MINT-7993644 MINT-7993837 MINT-7988296 MINT-7993717 I2D: score=1 STRING: ENSP00000221233
    EXOSC6Q5RKV62, 3, ENSP000003985974MINT-7993644 MINT-7993837 MINT-7988296 I2D: score=3 STRING: ENSP00000398597
    IP6K1Q925512, 3, ENSP000003237804MINT-68319 I2D: score=5 STRING: ENSP00000323780
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000288nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay TAS--
    GO:0006364rRNA processing TAS11849973
    GO:0006401RNA catabolic process NAS11719186
    GO:0010467gene expression TAS--
    GO:0016070RNA metabolic process TAS--

    Find genes that share ontologies with EXOSC7           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for EXOSC7 (EXOS7)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for EXOSC7 gene: 
    NM_015004.3  

    11 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000461361(uc003coh.1) ENST00000477865 ENST00000482004 ENST00000265564(uc003coi.2)
    ENST00000467846(uc011bae.2) ENST00000468667 ENST00000491476(uc010his.1)
    ENST00000481405 ENST00000498168 ENST00000486727 ENST00000459856
    miRNA
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    1 qRT-PCR Assays for microRNA that regulate EXOSC7:
    hsa-miR-590-3p
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
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      QuantiTect SYBR Green Assays in human, mouse, rat EXOSC7
      QuantiFast Probe-based Assays in human, mouse, rat EXOSC7

    Selected AceView cDNA sequences (see all 349):

    F07721 AW161589 BI834523 BF794114 BU527655 AW242429 AA379211 BU507745 
    CR595857 CB163139 BU683018 CR616454 BE256852 BM676188 BM931902 BU633135 
    BU630183 BM669340 BM789781 AW027344 T28091 BM684955 CR603652 NM_015004 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for EXOSC7 (see all 6)    About this scheme

    ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7a · 7b · 7c ^ 8a · 8b ^ 9a · 9b · 9c
    SP1:                                                              -                                             
    SP2:                    -     -                                   -                                             
    SP3:                                -     -                       -                                             
    SP4:                                                  -     -     -     -     -     -                           
    SP5:              -     -     -                                                                                 


    ECgene alternative splicing isoforms for EXOSC7

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    EXOSC7 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TAAAATTAAA
    EXOSC7 Expression
    About this image


    EXOSC7 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 4) fully expand
     
     Neural Tube (Nervous System)    fully expand to see all 3 entries
             Mesencephalic Ventricular Zone
     
     Thymus (Hematopoietic System)
             Thymus
     
     Kidney (Urinary System)
             Interstitial Stroma
     
     Brain (Nervous System)
             Medulla Oblongata
    EXOSC7 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    EXOSC7 Protein Expression
        Custom PCR Arrays for EXOSC7
    Primer
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for EXOSC7

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for EXOSC7 gene from Selected species (see all 20)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Exosc71 , 5 exosome component 71, 5 89.81(n)1
    95.53(a)1
      9 (73.80 cM)5
    664461  NM_001081188.11  NP_001074657.11 
     1231132155 
    chicken
    (Gallus gallus)
    Aves EXOSC71 exosome component 7 78.24(n)
    87.29(a)
      420704  NM_001252154.1  NP_001239083.1 
    lizard
    (Anolis carolinensis)
    Reptilia --
    --
    Uncharacterized protein
    85(a)
    76(a)
    1 ↔ many
    1 ↔ many
    AAWZ02038308(2615-12141)
    GL343611.1(354585-372746)
    African clawed frog
    (Xenopus laevis)
    Amphibia BQ732605.12   -- 78.6(n)    BQ732605.1 
    zebrafish
    (Danio rerio)
    Actinopterygii BI984599.12   -- 75.06(n)    BI984599.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Rrp421 Rrp42 54.83(n)
    49.31(a)
      36766  NM_166134.2  NP_725517.2 
    worm
    (Caenorhabditis elegans)
    Secernentea exos-76
    Protein EXOS-7 (exos-7) mRNA, complete cds
    32(a)
    1 ↔ 1
    V(20838865-20841581) WBGene00009289
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes RRP42(YDL111C)4 Exosome non-catalytic core component; involved in 3'-5' more   --   4(264110-263313) 851447  NP_010172.1 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons AT3G077501 AT3G07750 48.71(n)
    40.96(a)
      819966  NM_111654.3  NP_566318.1 
    rice
    (Oryza sativa)
    Liliopsida Os12g04038001 Os12g0403800 49.94(n)
    41.51(a)
      4352037  NM_001073154.1  NP_001066622.1 


    ENSEMBL Gene Tree for EXOSC7 (if available)
    TreeFam Gene Tree for EXOSC7 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for EXOSC7 gene
    EXOSC82  EXOSC92  
    1 SIMAP similar gene for EXOSC7 using alignment to 1 protein entry:     EXOS7_HUMAN:
    EXOSC8

    Find genes that share paralogs with EXOSC7           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for EXOSC7 (see all 666)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 3 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1893478601,2
    --45019692(+) ACGCCG/TGTAAT 2 -- int10--------
    rs2012155191,2
    --45019816(+) TAAAA-/AGAATTC 2 -- int10--------
    rs98431321,2
    C,F,H--45019835(+) TTGTAA/TTGCTC 2 -- int119Minor allele frequency- T:0.02NS EA NA 2038
    rs1822852661,2
    --45020185(+) GAAGGG/TGTGGT 2 -- int10--------
    rs1156170261,2
    F--45020206(+) ATCCTC/GAGGTG 2 -- int11Minor allele frequency- G:0.03WA 118
    rs1872764781,2
    --45020230(+) GCCCAA/TGGGGT 2 -- int10--------
    rs799392361,2
    F--45020504(+) TACCAT/CGGACA 2 -- int11Minor allele frequency- C:0.05WA 118
    rs1148820921,2
    C,F--45020538(+) ATGCTC/TAGCTC 2 -- int11Minor allele frequency- T:0.03WA 118
    rs1889717041,2
    --45020632(+) ATATGC/TATAGA 2 -- int10--------
    rs1479281451,2
    C--45020707(+) GAATCG/TCAACT 2 -- int10--------

    HapMap Linkage Disequilibrium report for EXOSC7 (45016733 - 45077558 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for EXOSC7:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2675874CNV Deletion23128226
    nsv508914CNV Insertion20534489
    nsv834676CNV Gain+Loss17160897

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing EXOSC7
    DNA2.0 Custom Variant and Variant Library Synthesis for EXOSC7

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 606488    OMIM disorders: --


    Find genes that share disorders with EXOSC7           About GenesLikeMe


    Export disorders for EXOSC7 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for EXOSC7 gene, integrated from 10 sources (see all 36):
    (articles sorted by number of sources associating them with EXOSC7)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Protein-protein interactions of hCsl4p with other human exosome subunits. (PubMed id 11812149)1, 2, 3, 9 Raijmakers R.... Pruijn G.J.M. (J. Mol. Biol. 2002)
    2. AU binding proteins recruit the exosome to degrade ARE-containing mRNAs. (PubMed id 11719186)1, 2, 3 Chen C.-Y.... Karin M. (Cell 2001)
    3. Dis3-like 1: a novel exoribonuclease associated with the human exosome. (PubMed id 20531389)1, 2 Staals R.H.... Pruijn G.J. (EMBO J. 2010)
    4. Reconstitution, activities, and structure of the eukaryotic RNA exosome. (PubMed id 17174896)1, 2 Liu Q.... Lima C.D. (Cell 2006)
    5. A protein interaction framework for human mRNA degradation. (PubMed id 15231747)1, 2 Lehner B. and Sanderson C.M. (Genome Res. 2004)
    6. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    7. Protein-protein interactions between human exosome components support the assembly of RNase PH-type subunits into a six-membered PNPase-like ring. (PubMed id 12419256)1, 2 Raijmakers R.... Pruijn G.J.M. (J. Mol. Biol. 2002)
    8. Prediction of the coding sequences of unidentified human genes. III. The coding sequences of 40 new genes (KIAA0081-KIAA0120) deduced by analysis of cDNA clones from human cell line KG-1. (PubMed id 7788527)1, 2 Nagase T.... Nomura N. (DNA Res. 1995)
    9. The HECT type ubiquitin ligase NEDL2 is degraded by anaphase-promoting complex/cyclosome (APC/C)-Cdh1, and its tight regulation maintains the metaphase to anaphase transition. (PubMed id 24163370)1 Lu L....Zhang L. (J. Biol. Chem. 2013)
    10. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (Cell 2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 23016 HGNC: 28112 AceView: TNAandEXOSC7 Ensembl:ENSG00000075914 euGenes: HUgn23016
    ECgene: EXOSC7 Kegg: 23016 H-InvDB: EXOSC7

    (According to HUGE)
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    HUGE: KIAA0116

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for EXOSC7 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for EXOSC7 gene:
    Search GeneIP for patents involving EXOSC7

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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