EXOSC5 Gene
protein-coding GIFtS: 57
GCID: GC19M041892
|
|
exosome component 5
| |
Aliases
for EXOSC5 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Exosome Component 51 2 3 | | Ribosomal RNA-Processing Protein 462 3 | | RRP461 2 3 | | MGC129011 | | P12B1 | | Exosome Complex Component RRP462 | | RRP41B1 2 | | Exosome Complex Exonuclease RRP462 | | Rrp46p1 2 | | Exosome Component Rrp462 | | HRrp46p1 | | CML283 | | Chronic Myelogenous Leukemia Tumor Antigen 282 3 | | |
Export aliases for EXOSC5 gene to outside databasesPrevious GC identifers: GC19M046585 GC19M046586 GC19M038324 |
Summaries
for EXOSC5 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
UniProtKB/Swiss-Prot: EXOS5_HUMAN, Q9NQT4Function: Non-catalytic component of the RNA exosome complex which has 3'->5' exoribonuclease activity and participatesin a multitude of cellular RNA processing and degradation events. In the nucleus, the RNA exosome complex is involvedin proper maturation of stable RNA species such as rRNA, snRNA and snoRNA, in the elimination of RNA processingby-products and non-coding 'pervasive' transcripts, such as antisense RNA species and promoter-upstream transcripts(PROMPTs), and of mRNAs with processing defects, thereby limiting or excluding their export to the cytoplasm. The RNAexosome may be involved in Ig class switch recombination (CSR) and/or Ig variable region somatic hypermutation (SHM)by targeting AICDA deamination activity to transcribed dsDNA substrates. In the cytoplasm, the RNA exosome complex isinvolved in general mRNA turnover and specifically degrades inherently unstable mRNAs containing AU-rich elements(AREs) within their 3' untranslated regions, and in RNA surveillance pathways, preventing translation of aberrantmRNAs. It seems to be involved in degradation of histone mRNA. The catalytic inactive RNA exosome core complex of 9subunits (Exo-9) is proposed to play a pivotal role in the binding and presentation of RNA for ribonucleolysis, and toserve as a scaffold for the association with catalytic subunits and accessory proteins or complexes
Gene Wiki entry for EXOSC5 (Exosome component 5)
|
Genomic Views
for EXOSC5 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000019.9 NC_018930.1 NT_011109.16
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the EXOSC5 gene promoter:
GR NF-1 USF1 AP-1 GR-beta USF2 USF-1:USF-2 E47 USF-1 GR-alpha
Other transcription factors
Search SABiosciences Chromatin IP Primers for EXOSC5
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat EXOSC5 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 19q13.1 Ensembl cytogenetic band: 19q13.2 HGNC cytogenetic band: 19q13.1EXOSC5 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 19 GeneLoc Exon Structure GeneLoc location for GC19M041892: view genomic region
(about GC identifiers)
Start:
|
41,892,275 bp from pter |
End:
|
41,903,256 bp from pter |
Size:
|
10,982 bases |
Orientation:
|
minus strand |
|
Proteins
for EXOSC5 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: EXOS5_HUMAN, Q9NQT4 (See
protein sequence)Recommended Name: Exosome complex component RRP46 Size: 235 amino acids; 25249 Da
Subunit: Component of the RNA exosome complex. Specifically part of the catalytically inactive RNA exosome core (Exo-9)complex which is believed to associate with catalytic subunits EXOSC10, and DIS3 or DIS3L in cytoplasmic- andnuclear-specific RNA exosome complex forms. Exo-9 is formed by a hexameric ring of RNase PH domain-containing subunitsspecifically containing the heterodimers EXOSC4-EXOSC9, EXOSC5-EXOSC8 and EXOSC6-EXOSC7, and peripheral S1domain-containing components EXOSC1, EXOSC2 and EXOSC3 located on the top of the ring structure. Interacts withEXOSC1. Interacts with GTPBP1. Interacts with ZC3HAV1. Interacts with DDX17 only in the presence of ZC3HAV1 in anRNA-independent manner
Subcellular location: Nucleus, nucleolus. Cytoplasm (Probable). Nucleus (Probable)
Caution: The six exosome core subunits containing a RNase PH-domain are not phosphorolytically active
Sequence caution: Sequence=AAM75154.1; Type=Erroneous initiation;
1 PDB 3D structure from  and Proteopedia  for EXOSC5:2NN6 (3D)
Secondary accessions: Q32Q81 Q8NG16 Q96I89Explore the universe of human proteins at neXtProt for EXOSC5: NX_Q9NQT4
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q9NQT4
EXOSC5 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_064543.3
ENSEMBL proteins: ENSP00000221233 Reactome Protein details: Q9NQT4
Human Recombinant Protein Products:
Gene Ontology (GO): 5 cellular component terms (GO ID links to tree view): About this table
EXOSC5 for ontologies About GeneDecksing
EXOSC5 Antibody Products:
Assay Products for EXOSC5: |
Protein
Domains /
Families
for EXOSC5 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
EXOSC5 for domains About GeneDecksing
3 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q9NQT4ProtoNet protein and cluster: Q9NQT4 UniProtKB/Swiss-Prot: EXOS5_HUMAN, Q9NQT4Similarity: Belongs to the RNase PH family |
Function
for EXOSC5 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: EXOS5_HUMAN, Q9NQT4Function: Non-catalytic component of the RNA exosome complex which has 3'->5' exoribonuclease activity and participatesin a multitude of cellular RNA processing and degradation events. In the nucleus, the RNA exosome complex is involvedin proper maturation of stable RNA species such as rRNA, snRNA and snoRNA, in the elimination of RNA processingby-products and non-coding 'pervasive' transcripts, such as antisense RNA species and promoter-upstream transcripts(PROMPTs), and of mRNAs with processing defects, thereby limiting or excluding their export to the cytoplasm. The RNAexosome may be involved in Ig class switch recombination (CSR) and/or Ig variable region somatic hypermutation (SHM)by targeting AICDA deamination activity to transcribed dsDNA substrates. In the cytoplasm, the RNA exosome complex isinvolved in general mRNA turnover and specifically degrades inherently unstable mRNAs containing AU-rich elements(AREs) within their 3' untranslated regions, and in RNA surveillance pathways, preventing translation of aberrantmRNAs. It seems to be involved in degradation of histone mRNA. The catalytic inactive RNA exosome core complex of 9subunits (Exo-9) is proposed to play a pivotal role in the binding and presentation of RNA for ribonucleolysis, and toserve as a scaffold for the association with catalytic subunits and accessory proteins or complexes
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for EXOSC5 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for EXOSC5
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: EXOSC5 (NM_020158) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for EXOSC5 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat EXOSC5 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for EXOSC5 |
Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view): About this table
EXOSC5 for ontologies About GeneDecksing
2 GenomeRNAi human phenotypes for EXOSC5:
|
Pathways & Interactions
for EXOSC5 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways - 5/6 super-pathways (see all 6) About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Destabilization of mRNA by Tristetraprolin (TTP) | | | 2 | Deadenylation-dependent mRNA decay | | | 3 | Metabolism of mRNA | | | 4 | ATP/ITP metabolism | | | 5 | Ubiquitinated Orc1 is degraded by the proteasome | |
Pathway sources
See GeneCards unified pathways
Show all pathways
1 EMD Millipore Pathway for EXOSC5
1  GeneGo (Thomson Reuters) Pathway for EXOSC5
5/9 
Reactome Pathways for EXOSC5 (see all 9)
1 
Kegg Pathway (Kegg details for EXOSC5):
EXOSC5 for pathways About GeneDecksing
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for EXOSC5
STRING Interaction
Network Preview (showing 5 interactants - click image to see 25)
5/62 Interacting proteins for EXOSC5 (Q9NQT41, 2, 3 ENSP000002212334) via UniProtKB, MINT, STRING, and/or I2D (see all 62)| Interactant | Interaction Details |
|---|
| GeneCard | External ID(s) |
|---|
| EXOSC1 | Q9Y3B21, 2, 3, ENSP000003599394 | EBI-371876,EBI-371892 MINT-7993644 MINT-7993837 MINT-7988296 MINT-7993717 I2D:
score=4 STRING: ENSP00000359939 | | EXOSC7 | Q150242, 3, ENSP000002655644 | MINT-7993644 MINT-7993837 MINT-7988296 MINT-7993717 I2D:
score=1 STRING: ENSP00000265564 | | EXOSC9 | Q062652, 3, ENSP000003689844 | MINT-7993644 MINT-7993837 MINT-7988296 MINT-7993717 I2D:
score=1 STRING: ENSP00000368984 | | EXOSC6 | Q5RKV62, 3, ENSP000003985974 | MINT-7993644 MINT-7993837 MINT-7988296 I2D:
score=1 STRING: ENSP00000398597 | | EXOSC8 | Q96B261, 2, 3, ENSP000003743544 | EBI-371876,EBI-371922 MINT-7993644 MINT-7993837 MINT-7988296 MINT-7993717 I2D:
score=4 STRING: ENSP00000374354 |
About this table
Gene Ontology (GO): 5/9 biological process terms (GO ID links to tree view) (see all 9): About this table
EXOSC5 for ontologies About GeneDecksing
|
Drugs & Compounds
for EXOSC5 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for EXOSC5
Search CenterWatch for drugs/clinical trials and news about EXOSC5 / EXOS5
|
Transcripts
for EXOSC5 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for EXOSC5 gene: NM_020158.3 Unigene Cluster for EXOSC5: Exosome component 5 Hs.283741 [show with all ESTs]Unigene Representative Sequence: BM4501051 Ensembl transcript including schematic representation, and UCSC links where relevant: ENST00000221233(uc002oqo.3)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for EXOSC5 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for EXOSC5
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: EXOSC5 (NM_020158) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for EXOSC5 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat EXOSC5 |
Additional cDNA sequence: AF281134.1 AF285785.1 AK314941.1 BC007742.2 BC107696.1 17 DOTS entries: DT.446730 DT.100697122 DT.100787486 DT.121460932 DT.100787480 DT.100787485 DT.100787479 DT.121461048 DT.121460787 DT.100711453 DT.100787483 DT.121460801 DT.121460897 DT.121461144 DT.40113849 DT.95237655 DT.99997857 24/223 AceView cDNA sequences (see all 223): AI887020 AI554713 AF281134 AI078748 CA444881 AI214223 BG396350 AI587094 BM704499 BU625964 BU956438 BU687910 BE274354 CA418848 CA945111 BX333742 BE619128 AI962516 BU557371 AI264531 AI359994 BX462406 AI700402 NM_020158
GeneLoc Exon Structure
4 Alternative Splicing Database (ASD) splice patterns (SP) for EXOSC5 About this scheme
| ExUns: | 1a | · | 1b | · | 1c | · | 1d | ^ | 2 | ^ | 3a | · | 3b | ^ | 4a | · | 4b | ^ | 5a | · | 5b | ^ | 6a | · | 6b |
|---|
|
| SP1: | | | | | | | | | | | | | - | | | | | | | | | | | | | | |
| SP2: | | | | | | | | | - | | | | - | | | | | | | | | | | | | | |
| SP3: | | | | | | | | | | | - | | - | | - | | | | | | | | | | | | |
| SP4: | | | | | | | | | | | | | | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for EXOSC5
|
Expression
for EXOSC5 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| EXOSC5 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GGCTCCTTGA
About this image
See EXOSC5 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for EXOSC5
SOURCE GeneReport for Unigene cluster: Hs.283741
UniProtKB/Swiss-Prot: EXOS5_HUMAN, Q9NQT4Tissue specificity: Highly expressed in a variety of hematopoietic and epithelial tumor cell lines, but not in normalhematopoietic tissues or other normal tissue, with the exception of testis
SABiosciences Custom PCR Arrays for EXOSC5
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for EXOSC5
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat EXOSC5 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat EXOSC5 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat EXOSC5 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for EXOSC5 |
Orthologs
for EXOSC5 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of eukaryotes.
Orthologs for EXOSC5 gene from 10/29 species (see all 29) About this table
ENSEMBL Gene Tree for EXOSC5 (if available)
TreeFam Gene Tree for EXOSC5 (if available) |
Paralogs
for EXOSC5 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| -- |
Genomic Variants
for EXOSC5 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 19 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for EXOSC5 (41892275 - 41903256 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for EXOSC5: -- | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing EXOSC5 |
|
Disorders
/ Diseases
for EXOSC5 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
EXOSC5 for disorders About GeneDecksing
OMIM gene information: 606492
OMIM disorders: --
3  diseases for EXOSC5: About MalaCardscat-scratch disease leukemia polymyositis
1 disease from the University of Copenhagen DISEASES database for EXOSC5:cat-scratch disease Human Genome Epidemiology (HuGE) Navigator: EXOSC5 (1 document)
Export disorders for EXOSC5 gene to outside databases
|
Publications
for EXOSC5 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for EXOSC5 gene, integrated from 9 sources (see all 39):
(articles sorted by number of sources associating them with EXOSC5) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Protein-protein interactions of hCsl4p with other human exosome subunits. (PubMed id 11812149)1, 2, 3, 9 Raijmakers R.... Pruijn G.J.M. (2002)
- Three novel components of the human exosome. (PubMed id 11110791)1, 2, 3 Brouwer R....Pruijn G.J. (2001)
- Dis3-like 1: a novel exoribonuclease associated with the human exosome. (PubMed id 20531389)1, 2 Staals R.H....Pruijn G.J. (2010)
- Reconstitution, activities, and structure of the eukaryotic RNA exosome. (PubMed id 17174896)1, 2 Liu Q.... Lima C.D. (2006)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- The mammalian exosome mediates the efficient degradation of mRNAs that contain AU-rich elements. (PubMed id 11782436)1, 2 Mukherjee D....Wilusz J. (2002)
- CML28 is a broadly immunogenic antigen, which is overexpressed in tumor cells. (PubMed id 12359762)1, 2 Yang X.-F.... Ritz J. (2002)
- AU binding proteins recruit the exosome to degrade ARE-containing mRNAs. (PubMed id 11719186)1, 2 Chen C.-Y.... Karin M. (2001)
- The yeast exosome and human PM-Scl are related complexes of 3'-->5' exonucleases. (PubMed id 10465791)1, 2 Allmang C....Mitchell P. (1999)
- A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (2012)
|
External Searches for EXOSC5 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing EXOSC5 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing EXOSC5 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing EXOSC5 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for EXOSC5 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for EXOSC5 gene:
Search GeneIP for patents involving EXOSC5
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for EXOSC5 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for EXOSC5 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for EXOSC5 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for EXOSC5 | | | OriGene Protein Over-expression Lysate for EXOSC5 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for EXOSC5 | | Browse 3'-UTR reporter clones for miRNA target validation | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for EXOSC5 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for EXOSC5 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | OriGene Purified Protein for EXOSC5 | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for EXOSC5 | | OriGene Custom Protein Services for EXOSC5 | | | OriGene Custom Immunoassay Development | | |
| |
 |
 |
| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat EXOSC5 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing EXOSC5 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat EXOSC5 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat EXOSC5 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat EXOSC5 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat EXOSC5 |
| |
 |  |  |  | |
| | | | Search Tocris compounds for EXOSC5 |
| |  |  |  |  | | | | | | Recombinant Protein for EXOSC5 |
|
 |
 |
 |
 | | | EXOSC5 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for EXOSC5 |
|  |  |  | | | | Search ThermoFisher Antibodies for EXOSC5 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat EXOSC5 |
|
|
|
|
