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Aliases for EXOSC5 Gene

Aliases for EXOSC5 Gene

  • Exosome Component 5 2 3 4 5
  • Chronic Myelogenous Leukemia Tumor Antigen 28 3 4
  • Ribosomal RNA-Processing Protein 46 3 4
  • Exosome Component Rrp46 2 3
  • RRP46 3 4
  • P12B 3 4
  • Exosome Complex Exonuclease RRP46 3
  • HRrp46p 3
  • RRP41B 3
  • Rrp46p 3
  • CML28 4

External Ids for EXOSC5 Gene

Previous GeneCards Identifiers for EXOSC5 Gene

  • GC19M046585
  • GC19M046586
  • GC19M041892
  • GC19M038324

Summaries for EXOSC5 Gene

GeneCards Summary for EXOSC5 Gene

EXOSC5 (Exosome Component 5) is a Protein Coding gene. Among its related pathways are Gene Expression and Transport to the Golgi and subsequent modification. GO annotations related to this gene include RNA binding and exoribonuclease activity.

UniProtKB/Swiss-Prot for EXOSC5 Gene

  • Non-catalytic component of the RNA exosome complex which has 3->5 exoribonuclease activity and participates in a multitude of cellular RNA processing and degradation events. In the nucleus, the RNA exosome complex is involved in proper maturation of stable RNA species such as rRNA, snRNA and snoRNA, in the elimination of RNA processing by-products and non-coding pervasive transcripts, such as antisense RNA species and promoter-upstream transcripts (PROMPTs), and of mRNAs with processing defects, thereby limiting or excluding their export to the cytoplasm. The RNA exosome may be involved in Ig class switch recombination (CSR) and/or Ig variable region somatic hypermutation (SHM) by targeting AICDA deamination activity to transcribed dsDNA substrates. In the cytoplasm, the RNA exosome complex is involved in general mRNA turnover and specifically degrades inherently unstable mRNAs containing AU-rich elements (AREs) within their 3 untranslated regions, and in RNA surveillance pathways, preventing translation of aberrant mRNAs. It seems to be involved in degradation of histone mRNA. The catalytic inactive RNA exosome core complex of 9 subunits (Exo-9) is proposed to play a pivotal role in the binding and presentation of RNA for ribonucleolysis, and to serve as a scaffold for the association with catalytic subunits and accessory proteins or complexes.

Gene Wiki entry for EXOSC5 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for EXOSC5 Gene

Genomics for EXOSC5 Gene

Regulatory Elements for EXOSC5 Gene

Promoters for EXOSC5 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around EXOSC5 on UCSC Golden Path with GeneCards custom track

Genomic Location for EXOSC5 Gene

Chromosome:
19
Start:
41,386,370 bp from pter
End:
41,397,479 bp from pter
Size:
11,110 bases
Orientation:
Minus strand

Genomic View for EXOSC5 Gene

Genes around EXOSC5 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
EXOSC5 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for EXOSC5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for EXOSC5 Gene

Proteins for EXOSC5 Gene

  • Protein details for EXOSC5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NQT4-EXOS5_HUMAN
    Recommended name:
    Exosome complex component RRP46
    Protein Accession:
    Q9NQT4
    Secondary Accessions:
    • Q32Q81
    • Q8NG16
    • Q96I89

    Protein attributes for EXOSC5 Gene

    Size:
    235 amino acids
    Molecular mass:
    25249 Da
    Quaternary structure:
    • Component of the RNA exosome complex. Specifically part of the catalytically inactive RNA exosome core (Exo-9) complex which is believed to associate with catalytic subunits EXOSC10, and DIS3 or DIS3L in cytoplasmic- and nuclear-specific RNA exosome complex forms. Exo-9 is formed by a hexameric ring of RNase PH domain-containing subunits specifically containing the heterodimers EXOSC4-EXOSC9, EXOSC5-EXOSC8 and EXOSC6-EXOSC7, and peripheral S1 domain-containing components EXOSC1, EXOSC2 and EXOSC3 located on the top of the ring structure. Interacts with EXOSC1. Interacts with GTPBP1. Interacts with ZC3HAV1. Interacts with DDX17 only in the presence of ZC3HAV1 in an RNA-independent manner.
    SequenceCaution:
    • Sequence=AAM75154.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for EXOSC5 Gene

neXtProt entry for EXOSC5 Gene

Proteomics data for EXOSC5 Gene at MOPED

Post-translational modifications for EXOSC5 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for EXOSC5 Gene

No data available for DME Specific Peptides for EXOSC5 Gene

Domains & Families for EXOSC5 Gene

Gene Families for EXOSC5 Gene

Protein Domains for EXOSC5 Gene

Suggested Antigen Peptide Sequences for EXOSC5 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9NQT4

UniProtKB/Swiss-Prot:

EXOS5_HUMAN :
  • Belongs to the RNase PH family.
Family:
  • Belongs to the RNase PH family.
genes like me logo Genes that share domains with EXOSC5: view

Function for EXOSC5 Gene

Molecular function for EXOSC5 Gene

UniProtKB/Swiss-Prot Function:
Non-catalytic component of the RNA exosome complex which has 3->5 exoribonuclease activity and participates in a multitude of cellular RNA processing and degradation events. In the nucleus, the RNA exosome complex is involved in proper maturation of stable RNA species such as rRNA, snRNA and snoRNA, in the elimination of RNA processing by-products and non-coding pervasive transcripts, such as antisense RNA species and promoter-upstream transcripts (PROMPTs), and of mRNAs with processing defects, thereby limiting or excluding their export to the cytoplasm. The RNA exosome may be involved in Ig class switch recombination (CSR) and/or Ig variable region somatic hypermutation (SHM) by targeting AICDA deamination activity to transcribed dsDNA substrates. In the cytoplasm, the RNA exosome complex is involved in general mRNA turnover and specifically degrades inherently unstable mRNAs containing AU-rich elements (AREs) within their 3 untranslated regions, and in RNA surveillance pathways, preventing translation of aberrant mRNAs. It seems to be involved in degradation of histone mRNA. The catalytic inactive RNA exosome core complex of 9 subunits (Exo-9) is proposed to play a pivotal role in the binding and presentation of RNA for ribonucleolysis, and to serve as a scaffold for the association with catalytic subunits and accessory proteins or complexes.
genes like me logo Genes that share phenotypes with EXOSC5: view

Animal Model Products

  • Taconic Biosciences Mouse Models for EXOSC5

miRNA for EXOSC5 Gene

miRTarBase miRNAs that target EXOSC5

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for EXOSC5 Gene

Localization for EXOSC5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for EXOSC5 Gene

Nucleus, nucleolus. Cytoplasm. Nucleus.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for EXOSC5 Gene COMPARTMENTS Subcellular localization image for EXOSC5 gene
Compartment Confidence
cytosol 5
nucleus 5
extracellular 2
golgi apparatus 1
mitochondrion 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for EXOSC5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA --
genes like me logo Genes that share ontologies with EXOSC5: view

Pathways & Interactions for EXOSC5 Gene

genes like me logo Genes that share pathways with EXOSC5: view

Pathways by source for EXOSC5 Gene

Gene Ontology (GO) - Biological Process for EXOSC5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016075 rRNA catabolic process IBA --
GO:0034427 nuclear-transcribed mRNA catabolic process, exonucleolytic, 3-5 IBA --
GO:0043928 exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay TAS --
GO:0051607 defense response to virus IMP 21791617
genes like me logo Genes that share ontologies with EXOSC5: view

No data available for SIGNOR curated interactions for EXOSC5 Gene

Drugs & Compounds for EXOSC5 Gene

No Compound Related Data Available

Transcripts for EXOSC5 Gene

Unigene Clusters for EXOSC5 Gene

Exosome component 5:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for EXOSC5 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3a · 3b ^ 4a · 4b ^ 5a · 5b ^ 6a · 6b
SP1: -
SP2: - -
SP3: - - -
SP4:

Relevant External Links for EXOSC5 Gene

GeneLoc Exon Structure for
EXOSC5
ECgene alternative splicing isoforms for
EXOSC5

Expression for EXOSC5 Gene

mRNA expression in normal human tissues for EXOSC5 Gene

Protein differential expression in normal tissues from HIPED for EXOSC5 Gene

This gene is overexpressed in Lung (19.2) and Liver (16.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for EXOSC5 Gene



SOURCE GeneReport for Unigene cluster for EXOSC5 Gene Hs.283741

mRNA Expression by UniProt/SwissProt for EXOSC5 Gene

Q9NQT4-EXOS5_HUMAN
Tissue specificity: Highly expressed in a variety of hematopoietic and epithelial tumor cell lines, but not in normal hematopoietic tissues or other normal tissue, with the exception of testis.
genes like me logo Genes that share expression patterns with EXOSC5: view

Protein tissue co-expression partners for EXOSC5 Gene

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for EXOSC5 Gene

Orthologs for EXOSC5 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for EXOSC5 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia EXOSC5 36
  • 99 (a)
OneToOne
EXOSC5 35
  • 98.87 (n)
  • 98.72 (a)
cow
(Bos Taurus)
Mammalia EXOSC5 36
  • 91 (a)
OneToOne
EXOSC5 35
  • 87.66 (n)
  • 91.49 (a)
dog
(Canis familiaris)
Mammalia EXOSC5 35
  • 88.65 (n)
  • 93.19 (a)
EXOSC5 36
  • 93 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Exosc5 36
  • 89 (a)
OneToOne
Exosc5 16
Exosc5 35
  • 84.68 (n)
  • 89.36 (a)
oppossum
(Monodelphis domestica)
Mammalia EXOSC5 36
  • 84 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Exosc5 35
  • 84.54 (n)
  • 89.36 (a)
chicken
(Gallus gallus)
Aves EXOSC5 36
  • 72 (a)
OneToOne
EXOSC5 35
  • 72.73 (n)
  • 74.55 (a)
lizard
(Anolis carolinensis)
Reptilia EXOSC5 36
  • 65 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.9395 35
tropical clawed frog
(Silurana tropicalis)
Amphibia exosc5 35
  • 66.35 (n)
  • 72.51 (a)
Str.1521 35
zebrafish
(Danio rerio)
Actinopterygii Dr.17708 35
exosc5 35
  • 60.71 (n)
  • 65.22 (a)
exosc5 36
  • 61 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP002177 35
  • 49.75 (n)
  • 35.47 (a)
fruit fly
(Drosophila melanogaster)
Insecta Rrp46 36
  • 35 (a)
OneToOne
Rrp46 35
  • 46.96 (n)
  • 38.46 (a)
worm
(Caenorhabditis elegans)
Secernentea crn-5 36
  • 30 (a)
OneToOne
crn-5 35
  • 42.08 (n)
  • 32.67 (a)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AAR035C 35
  • 48.95 (n)
  • 41.77 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes RRP46 36
  • 26 (a)
OneToOne
RRP46 38
thale cress
(Arabidopsis thaliana)
eudicotyledons AT3G46210 35
  • 48.56 (n)
  • 43.75 (a)
rice
(Oryza sativa)
Liliopsida Os03g0854200 35
  • 49.12 (n)
  • 38.76 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.6933 36
  • 37 (a)
OneToOne
Species with no ortholog for EXOSC5:
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for EXOSC5 Gene

ENSEMBL:
Gene Tree for EXOSC5 (if available)
TreeFam:
Gene Tree for EXOSC5 (if available)

Paralogs for EXOSC5 Gene

No data available for Paralogs for EXOSC5 Gene

Variants for EXOSC5 Gene

Sequence variations from dbSNP and Humsavar for EXOSC5 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
VAR_030788 -
VAR_051868 -
rs3745289 -- 41,389,947(-) ctcca(A/G)aaaaa intron-variant
rs8103531 -- 41,386,069(+) TAGCT(C/T)GCTGG downstream-variant-500B
rs10413269 -- 41,390,642(+) ATGGA(A/G)GAAGA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for EXOSC5 Gene

Variant ID Type Subtype PubMed ID
nsv828551 CNV Gain 20364138

Variation tolerance for EXOSC5 Gene

Residual Variation Intolerance Score: 69.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.88; 18.35% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for EXOSC5 Gene

HapMap Linkage Disequilibrium report
EXOSC5

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for EXOSC5 Gene

Disorders for EXOSC5 Gene

Relevant External Links for EXOSC5

Genetic Association Database (GAD)
EXOSC5
Human Genome Epidemiology (HuGE) Navigator
EXOSC5
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
EXOSC5

No disorders were found for EXOSC5 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for EXOSC5 Gene

Publications for EXOSC5 Gene

  1. Protein-protein interactions of hCsl4p with other human exosome subunits. (PMID: 11812149) Raijmakers R. … Pruijn G.J.M. (J. Mol. Biol. 2002) 2 3 4 23 67
  2. Three novel components of the human exosome. (PMID: 11110791) Brouwer R. … Pruijn G.J.M. (J. Biol. Chem. 2001) 2 3
  3. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  4. Panorama of ancient metazoan macromolecular complexes. (PMID: 26344197) Wan C. … Emili A. (Nature 2015) 3
  5. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 3

Products for EXOSC5 Gene

Sources for EXOSC5 Gene

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