EXOSC4 Gene
protein-coding GIFtS: 53
GCID: GC08P145133
|
|
exosome component 4
| |
Aliases
for EXOSC4 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Exosome Component 41 2 3 | | HRrp41p1 | | RRP411 2 3 | | Ribosomal RNA-Processing Protein 412 3 | | SKI61 2 3 | | FLJ205911 | | P12A1 | | Exosome Complex Component RRP412 | | RRP41A1 2 | | Exosome Complex Exonuclease RRP412 | | Rrp41p1 2 | | Exosome Component Rrp412 | | Ski6p1 2 | | |
Export aliases for EXOSC4 gene to outside databasesPrevious GC identifers: GC08P145240 GC08P145205 GC08P140409 |
Summaries
for EXOSC4 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
UniProtKB/Swiss-Prot: EXOS4_HUMAN, Q9NPD3Function: Non-catalytic component of the RNA exosome complex which has 3'->5' exoribonuclease activity and participatesin a multitude of cellular RNA processing and degradation events. In the nucleus, the RNA exosome complex is involvedin proper maturation of stable RNA species such as rRNA, snRNA and snoRNA, in the elimination of RNA processingby-products and non-coding 'pervasive' transcripts, such as antisense RNA species and promoter-upstream transcripts(PROMPTs), and of mRNAs with processing defects, thereby limiting or excluding their export to the cytoplasm. The RNAexosome may be involved in Ig class switch recombination (CSR) and/or Ig variable region somatic hypermutation (SHM)by targeting AICDA deamination activity to transcribed dsDNA substrates. In the cytoplasm, the RNA exosome complex isinvolved in general mRNA turnover and specifically degrades inherently unstable mRNAs containing AU-rich elements(AREs) within their 3' untranslated regions, and in RNA surveillance pathways, preventing translation of aberrantmRNAs. It seems to be involved in degradation of histone mRNA. The catalytic inactive RNA exosome core complex of 9subunits (Exo-9) is proposed to play a pivotal role in the binding and presentation of RNA for ribonucleolysis, and toserve as a scaffold for the association with catalytic subunits and accessory proteins or complexes. EXOSC4 binds toARE-containing RNAs
Gene Wiki entry for EXOSC4 (Exosome component 4)
|
Genomic Views
for EXOSC4 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000008.10 NC_018919.1 NT_008046.16
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the EXOSC4 gene promoter:
Egr-3 E2F-4 E2F-3a E2F-5 COUP E2F-2 c-Ets-1 E2F E2F-1
Other transcription factors
Search SABiosciences Chromatin IP Primers for EXOSC4
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat EXOSC4 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 8q24.3 Ensembl cytogenetic band: 8q24.3 HGNC cytogenetic band: 8q24.3EXOSC4 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 8 GeneLoc Exon Structure GeneLoc location for GC08P145133: view genomic region
(about GC identifiers)
Start:
|
145,133,522 bp from pter |
End:
|
145,135,551 bp from pter |
Size:
|
2,030 bases |
Orientation:
|
plus strand |
1 alternative location:
| Chr8+,PATCHES 145,147,156-145,149,185 |
|
Proteins
for EXOSC4 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: EXOS4_HUMAN, Q9NPD3 (See
protein sequence)Recommended Name: Exosome complex component RRP41 Size: 245 amino acids; 26383 Da
Subunit: Component of the RNA exosome complex. Specifically part of the catalytically inactive RNA exosome core (Exo-9)complex which is believed to associate with catalytic subunits EXOSC10, and DIS3 or DIS3L in cytoplasmic- andnuclear-specific RNA exosome complex forms. Exo-9 is formed by a hexameric ring of RNase PH domain-containing subunitsspecifically containing the heterodimers EXOSC4-EXOSC9, EXOSC5-EXOSC8 and EXOSC6-EXOSC7, and peripheral S1domain-containing components EXOSC1, EXOSC2 and EXOSC3 located on the top of the ring structure. Interacts with DDX60
Subcellular location: Cytoplasm. Nucleus, nucleolus. Nucleus
Caution: The six exosome core subunits containing a RNase PH-domain are not phosphorolytically active
1 PDB 3D structure from  and Proteopedia  for EXOSC4:2NN6 (3D)
Explore the universe of human proteins at neXtProt for EXOSC4: NX_Q9NPD3
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q9NPD3
EXOSC4 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_061910.1
ENSEMBL proteins: ENSP00000315476 ENSP00000432661 ENSP00000436539 Reactome Protein details: Q9NPD3
Human Recombinant Protein Products:
Gene Ontology (GO): 5/6 cellular component terms (GO ID links to tree view) (see all 6): About this table
EXOSC4 for ontologies About GeneDecksing
EXOSC4 Antibody Products:
Assay Products for EXOSC4: |
Protein
Domains /
Families
for EXOSC4 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
EXOSC4 for domains About GeneDecksing
3 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q9NPD3ProtoNet protein and cluster: Q9NPD3 UniProtKB/Swiss-Prot: EXOS4_HUMAN, Q9NPD3Similarity: Belongs to the RNase PH family |
Function
for EXOSC4 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: EXOS4_HUMAN, Q9NPD3Function: Non-catalytic component of the RNA exosome complex which has 3'->5' exoribonuclease activity and participatesin a multitude of cellular RNA processing and degradation events. In the nucleus, the RNA exosome complex is involvedin proper maturation of stable RNA species such as rRNA, snRNA and snoRNA, in the elimination of RNA processingby-products and non-coding 'pervasive' transcripts, such as antisense RNA species and promoter-upstream transcripts(PROMPTs), and of mRNAs with processing defects, thereby limiting or excluding their export to the cytoplasm. The RNAexosome may be involved in Ig class switch recombination (CSR) and/or Ig variable region somatic hypermutation (SHM)by targeting AICDA deamination activity to transcribed dsDNA substrates. In the cytoplasm, the RNA exosome complex isinvolved in general mRNA turnover and specifically degrades inherently unstable mRNAs containing AU-rich elements(AREs) within their 3' untranslated regions, and in RNA surveillance pathways, preventing translation of aberrantmRNAs. It seems to be involved in degradation of histone mRNA. The catalytic inactive RNA exosome core complex of 9subunits (Exo-9) is proposed to play a pivotal role in the binding and presentation of RNA for ribonucleolysis, and toserve as a scaffold for the association with catalytic subunits and accessory proteins or complexes. EXOSC4 binds toARE-containing RNAs
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for EXOSC4 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for EXOSC4
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: EXOSC4 (NM_019037) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for EXOSC4 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat EXOSC4 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for EXOSC4 |
Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view): About this table
EXOSC4 for ontologies About GeneDecksing
6 GenomeRNAi human phenotypes for EXOSC4:
|
Pathways & Interactions
for EXOSC4 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways - 5/6 super-pathways (see all 6) About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Destabilization of mRNA by Tristetraprolin (TTP) | | | 2 | Deadenylation-dependent mRNA decay | | | 3 | Metabolism of mRNA | | | 4 | ATP/ITP metabolism | | | 5 | Ubiquitinated Orc1 is degraded by the proteasome | |
Pathway sources
See GeneCards unified pathways
Show all pathways
1 EMD Millipore Pathway for EXOSC4
1  GeneGo (Thomson Reuters) Pathway for EXOSC4
5/9 
Reactome Pathways for EXOSC4 (see all 9)
1 
Kegg Pathway (Kegg details for EXOSC4):
EXOSC4 for pathways About GeneDecksing
Interactions:
SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for EXOSC4
STRING Interaction
Network Preview (showing 5 interactants - click image to see 25)
5/109 Interacting proteins for EXOSC4 (Q9NPD31, 2, 3 ENSP000003154764) via UniProtKB, MINT, STRING, and/or I2D (see all 109)| Interactant | Interaction Details |
|---|
| GeneCard | External ID(s) |
|---|
| EXOSC1 | Q9Y3B21, 2, 3, ENSP000003599394 | EBI-371823,EBI-371892 MINT-7993644 MINT-7993893 MINT-7993837 MINT-7988296 MINT-7993717 I2D:
score=4 STRING: ENSP00000359939 | | EXOSC3 | Q9NQT51, 2, 3, ENSP000003230464 | EBI-371823,EBI-371866 MINT-7993644 MINT-7993837 MINT-7988296 I2D:
score=7 STRING: ENSP00000323046 | | EXOSC7 | Q150242, 3, ENSP000002655644 | MINT-7993644 MINT-7993893 MINT-7993837 MINT-7988296 MINT-7993717 I2D:
score=4 STRING: ENSP00000265564 | | EXOSC6 | Q5RKV62, 3, ENSP000003985974 | MINT-7993644 MINT-7993837 MINT-7988296 I2D:
score=1 STRING: ENSP00000398597 | | EXOSC2 | Q138681, 2, 3, ENSP000003614334 | EBI-371823,EBI-301735 MINT-7993644 MINT-7993893 MINT-7993837 MINT-7988296 MINT-7993717 MINT-7993943 I2D:
score=11 STRING: ENSP00000361433 |
About this table
Gene Ontology (GO): 5/13 biological process terms (GO ID links to tree view) (see all 13): About this table
EXOSC4 for ontologies About GeneDecksing
|
Drugs & Compounds
for EXOSC4 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for EXOSC4
Search CenterWatch for drugs/clinical trials and news about EXOSC4 / EXOS4
|
Transcripts
for EXOSC4 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for EXOSC4 gene: NM_019037.2 Unigene Cluster for EXOSC4: Exosome component 4 Hs.632041 [show with all ESTs]Unigene Representative Sequence: BM9114153 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000316052(uc003zau.3) ENST00000525936 ENST00000527954
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for EXOSC4 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for EXOSC4
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: EXOSC4 (NM_019037) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for EXOSC4 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat EXOSC4 |
Additional cDNA sequence: AF281133.1 AK000598.1 BC002777.2 5 DOTS entries: DT.452652 DT.40133087 DT.92424241 DT.120630996 DT.97842770 24/108 AceView cDNA sequences (see all 108): AK000598 BQ055595 BM552746 BU623773 BQ233429 BU726431 AW593482 BU622874 CD673896 AI652670 F34414 BQ721052 BQ059657 AI073445 BM670476 BC002777 BM700289 BM839994 BG699798 AA435870 AW406799 BM564290 BU627720 AF281133
GeneLoc Exon Structure
|
Expression
for EXOSC4 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| EXOSC4 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TCCAGAATAA
About this image
See EXOSC4 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for EXOSC4
SOURCE GeneReport for Unigene cluster: Hs.632041
SABiosciences Custom PCR Arrays for EXOSC4
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for EXOSC4
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat EXOSC4 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat EXOSC4 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat EXOSC4 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for EXOSC4 |
Orthologs
for EXOSC4 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of eukaryotes.
Orthologs for EXOSC4 gene from 8/35 species (see all 35) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
lizard
(Anolis carolinensis) |
Reptilia |
EXOSC46 |
-- |
73(a) |
1 ↔ 1 |
AAWZ02038744(4435-8039) |
African clawed frog
(Xenopus laevis) |
Amphibia |
Xl.80742 |
Xenopus laevis transcribed sequence with moderate similarity more |
81.03(n) |
|
BJ065907.1 |
zebrafish
(Danio rerio) |
Actinopterygii |
zgc731752 |
putative exosome complex exonuclease RRP41 |
77.29(n) |
|
393712 BC059525.1 |
fruit fly
(Drosophila melanogaster) |
Insecta |
Ski61 |
CG15481-PA |
58.44(n)
55.07(a) |
|
34721 NM_135774.2 NP_609618.2 |
worm
(Caenorhabditis elegans) |
Secernentea |
exos-4.11 |
EXOSome (multiexonuclease complex) component |
49.17(n)
43.75(a) |
|
178261 NM_001026103.5 NP_001021274.1 |
baker's yeast
(Saccharomyces cerevisiae) |
Saccharomycetes |
SKI61 |
Ski6p |
43.64(n)
36.02(a) |
|
853109 NP_011711.3 |
thale cress
(Arabidopsis thaliana) |
eudicotyledons |
RRP411 |
exosome complex component RRP41 |
51.57(n)
48.29(a) |
|
825335 NM_116027.4 NP_191721.1 |
rice
(Oryza sativa) |
Liliopsida |
-- |
exosome complex exonuclease, putative, expressed |
48(a) |
1 ↔ 1 |
9(3958855-3964192) |
ENSEMBL Gene Tree for EXOSC4 (if available)
TreeFam Gene Tree for EXOSC4 (if available) |
Paralogs
for EXOSC4 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for EXOSC4 gene
- EXOSC62
EXOSC4 for paralogs About GeneDecksing
|
Genomic Variants
for EXOSC4 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 8 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for EXOSC4 (145133522 - 145135551 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 6 variations for EXOSC4
6 CNVs: 23290 30304 53614 30305 3751 30306 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing EXOSC4 |
|
Disorders
/ Diseases
for EXOSC4 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
EXOSC4 for disorders About GeneDecksing
OMIM gene information: 606491
OMIM disorders: --
4  diseases for EXOSC4: About MalaCardsmouth disease hepatitis a hepatitis malaria
Export disorders for EXOSC4 gene to outside databases
|
Publications
for EXOSC4 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for EXOSC4 gene, integrated from 9 sources (see all 33):
(articles sorted by number of sources associating them with EXOSC4) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Three novel components of the human exosome. (PubMed id 11110791)1, 2, 3 Brouwer R....Pruijn G.J. (2001)
- Dis3-like 1: a novel exoribonuclease associated with the human exosome. (PubMed id 20531389)1, 2 Staals R.H....Pruijn G.J. (2010)
- Degradation of histone mRNA requires oligouridylation followed by decapping and simultaneous degradation of the mRNA both 5' to 3' and 3' to 5'. (PubMed id 18172165)1, 2 Mullen T.E. and Marzluff W.F. (2008)
- Human cell growth requires a functional cytoplasmic exosome, which is involved in various mRNA decay pathways. (PubMed id 17545563)1, 2 van Dijk E.L....Pruijn G.J. (2007)
- Reconstitution, activities, and structure of the eukaryotic RNA exosome. (PubMed id 17174896)1, 2 Liu Q.... Lima C.D. (2006)
- Sequence-specific RNA binding mediated by the RNase PH domain of components of the exosome. (PubMed id 16912217)1, 2 Anderson J.R....Wilusz J. (2006)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- AU binding proteins recruit the exosome to degrade ARE-containing mRNAs. (PubMed id 11719186)1, 2 Chen C.-Y.... Karin M. (2001)
- The yeast exosome and human PM-Scl are related complexes of 3'-->5' exonucleases. (PubMed id 10465791)1, 2 Allmang C....Mitchell P. (1999)
|
External Searches for EXOSC4 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing EXOSC4 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing EXOSC4 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing EXOSC4 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for EXOSC4 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for EXOSC4 gene:
Search GeneIP for patents involving EXOSC4
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for EXOSC4 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
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| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for EXOSC4 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for EXOSC4 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for EXOSC4 | | | OriGene Protein Over-expression Lysate for EXOSC4 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for EXOSC4 | | OriGene 3'-UTR Clone for EXOSC4 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for EXOSC4 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for EXOSC4 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for EXOSC4 | | OriGene Custom Protein Services for EXOSC4 | | | OriGene Custom Immunoassay Development | | |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat EXOSC4 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing EXOSC4 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat EXOSC4 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat EXOSC4 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat EXOSC4 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat EXOSC4 |
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| | | | Search Tocris compounds for EXOSC4 |
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 | | | EXOSC4 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for EXOSC4 |
|  |  |  | | | | Search ThermoFisher Antibodies for EXOSC4 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat EXOSC4 |
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