Free for academic non-profit institutions. Other users need a Commercial license

Aliases for EXOSC3 Gene

Aliases for EXOSC3 Gene

  • Exosome Component 3 2 3 4 5
  • Ribosomal RNA-Processing Protein 40 3 4
  • RRP40 3 4
  • P10 3 4
  • Exosome Complex Exonuclease RRP40 3
  • Exosome Complex Component RRP40 3
  • Exosome Component Rrp40 2
  • CGI-102 Protein 2
  • BA3J10.7 3
  • CGI-102 3
  • HRrp-40 3
  • Rrp40p 3
  • PCH1B 3

External Ids for EXOSC3 Gene

Previous GeneCards Identifiers for EXOSC3 Gene

  • GC09M037771

Summaries for EXOSC3 Gene

Entrez Gene Summary for EXOSC3 Gene

  • This gene encodes a non-catalytic component of the human exosome, a complex with 3'-5' exoribonuclease activity that plays a role in numerous RNA processing and degradation activities. Related pseudogenes of this gene are found on chromosome 19 and 21. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Jun 2012]

GeneCards Summary for EXOSC3 Gene

EXOSC3 (Exosome Component 3) is a Protein Coding gene. Diseases associated with EXOSC3 include Pontocerebellar Hypoplasia, Type 1B and Exosc3-Related Pontocerebellar Hypoplasia. Among its related pathways are CDK-mediated phosphorylation and removal of Cdc6 and Pyrimidine metabolism (KEGG). GO annotations related to this gene include RNA binding and exoribonuclease activity.

UniProtKB/Swiss-Prot for EXOSC3 Gene

  • Non-catalytic component of the RNA exosome complex which has 3->5 exoribonuclease activity and participates in a multitude of cellular RNA processing and degradation events. In the nucleus, the RNA exosome complex is involved in proper maturation of stable RNA species such as rRNA, snRNA and snoRNA, in the elimination of RNA processing by-products and non-coding pervasive transcripts, such as antisense RNA species and promoter-upstream transcripts (PROMPTs), and of mRNAs with processing defects, thereby limiting or excluding their export to the cytoplasm. The RNA exosome may be involved in Ig class switch recombination (CSR) and/or Ig variable region somatic hypermutation (SHM) by targeting AICDA deamination activity to transcribed dsDNA substrates. In the cytoplasm, the RNA exosome complex is involved in general mRNA turnover and specifically degrades inherently unstable mRNAs containing AU-rich elements (AREs) within their 3 untranslated regions, and in RNA surveillance pathways, preventing translation of aberrant mRNAs. It seems to be involved in degradation of histone mRNA. The catalytic inactive RNA exosome core complex of 9 subunits (Exo-9) is proposed to play a pivotal role in the binding and presentation of RNA for ribonucleolysis, and to serve as a scaffold for the association with catalytic subunits and accessory proteins or complexes. EXOSC3 as peripheral part of the Exo-9 complex stabilizes the hexameric ring of RNase PH-domain subunits through contacts with EXOSC9 and EXOSC5.

Gene Wiki entry for EXOSC3 Gene

Additional gene information for EXOSC3 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for EXOSC3 Gene

Genomics for EXOSC3 Gene

Regulatory Elements for EXOSC3 Gene

Enhancers for EXOSC3 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH09H037463 1.4 ENCODE dbSUPER 41 +335.2 335173 5 HDGF PKNOX1 FOXA2 ARNT ARID4B SIN3A DMAP1 YY1 FOS SP3 DCAF10 EXOSC3 ZCCHC7 ZBTB5 RPL21P83 RNF38 TRMT10B GRHPR ALDH1B1 TMX2P1
GH09H037799 1.2 ENCODE 38.4 +0.3 309 2 MLX ZFP64 FEZF1 DMAP1 YY1 SLC30A9 ZNF416 ZNF143 SP3 NFYC TRMT10B EXOSC3 ZCCHC7 POLR1E ZBTB5 LINC01400 SLC25A51 DCAF10
GH09H037119 1.4 ENCODE dbSUPER 30.6 +680.6 680556 2 HDGF PKNOX1 MLX ARNT ZFP64 ARID4B SIN3A DMAP1 ZBTB7B YY1 ZCCHC7 EXOSC3 DCAF10 TRMT10B ZBTB5 HMGB3P24 GC09P037160
GH09H038021 1.5 Ensembl ENCODE dbSUPER 27.3 -224.1 -224084 7 FOXA2 PKNOX1 MLX ARID4B SIN3A FEZF1 DMAP1 YY1 ZNF121 GLIS2 EXOSC3 SHB TMX2P1 DCAF10 SLC25A51 ZCCHC7 ZBTB5 ENSG00000255872 RNU7-124P GC09P038069
GH09H037485 1.3 ENCODE dbSUPER 22.6 +314.6 314637 3 HDGF FOXA2 PKNOX1 ATF1 ARNT ARID4B SIN3A DMAP1 YY1 GLIS2 RPL21P83 POLR1E ZCCHC7 EXOSC3 ZBTB5 FBXO10 ENSG00000234160 TRMT10B TOMM5 ENSG00000256966
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around EXOSC3 on UCSC Golden Path with GeneCards custom track

Promoters for EXOSC3 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000234904 137 2201 MLX ZFP64 FEZF1 DMAP1 YY1 SLC30A9 ZNF143 SP3 NFYC ZC3H11A

Genomic Location for EXOSC3 Gene

Chromosome:
9
Start:
37,766,978 bp from pter
End:
37,801,437 bp from pter
Size:
34,460 bases
Orientation:
Minus strand

Genomic View for EXOSC3 Gene

Genes around EXOSC3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
EXOSC3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for EXOSC3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for EXOSC3 Gene

Proteins for EXOSC3 Gene

  • Protein details for EXOSC3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NQT5-EXOS3_HUMAN
    Recommended name:
    Exosome complex component RRP40
    Protein Accession:
    Q9NQT5
    Secondary Accessions:
    • A8K0K6
    • Q5QP85
    • Q9Y3A8

    Protein attributes for EXOSC3 Gene

    Size:
    275 amino acids
    Molecular mass:
    29572 Da
    Quaternary structure:
    • Component of the RNA exosome complex. Specifically part of the catalytically inactive RNA exosome core (Exo-9) complex which is believed to associate with catalytic subunits EXOSC10, and DIS3 or DIS3L in cytoplasmic- and nuclear-specific RNA exosome complex forms. Exo-9 is formed by a hexameric ring of RNase PH domain-containing subunits specifically containing the heterodimers EXOSC4-EXOSC9, EXOSC5-EXOSC8 and EXOSC6-EXOSC7, and peripheral S1 domain-containing components EXOSC1, EXOSC2 and EXOSC3 located on the top of the ring structure. Interacts with GTPBP1. Interacts with ZC3HAV1. Interacts with DDX17 only in the presence of ZC3HAV1 in an RNA-independent manner.

    Three dimensional structures from OCA and Proteopedia for EXOSC3 Gene

    Alternative splice isoforms for EXOSC3 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for EXOSC3 Gene

Post-translational modifications for EXOSC3 Gene

  • Ubiquitination at isoforms=2113
  • Modification sites at PhosphoSitePlus

Other Protein References for EXOSC3 Gene

No data available for DME Specific Peptides for EXOSC3 Gene

Domains & Families for EXOSC3 Gene

Gene Families for EXOSC3 Gene

HGNC:
Human Protein Atlas (HPA):
  • Disease related genes
  • Predicted intracellular proteins

Protein Domains for EXOSC3 Gene

Suggested Antigen Peptide Sequences for EXOSC3 Gene

Graphical View of Domain Structure for InterPro Entry

Q9NQT5

UniProtKB/Swiss-Prot:

EXOS3_HUMAN :
  • Belongs to the RRP40 family.
Family:
  • Belongs to the RRP40 family.
genes like me logo Genes that share domains with EXOSC3: view

Function for EXOSC3 Gene

Molecular function for EXOSC3 Gene

UniProtKB/Swiss-Prot Function:
Non-catalytic component of the RNA exosome complex which has 3->5 exoribonuclease activity and participates in a multitude of cellular RNA processing and degradation events. In the nucleus, the RNA exosome complex is involved in proper maturation of stable RNA species such as rRNA, snRNA and snoRNA, in the elimination of RNA processing by-products and non-coding pervasive transcripts, such as antisense RNA species and promoter-upstream transcripts (PROMPTs), and of mRNAs with processing defects, thereby limiting or excluding their export to the cytoplasm. The RNA exosome may be involved in Ig class switch recombination (CSR) and/or Ig variable region somatic hypermutation (SHM) by targeting AICDA deamination activity to transcribed dsDNA substrates. In the cytoplasm, the RNA exosome complex is involved in general mRNA turnover and specifically degrades inherently unstable mRNAs containing AU-rich elements (AREs) within their 3 untranslated regions, and in RNA surveillance pathways, preventing translation of aberrant mRNAs. It seems to be involved in degradation of histone mRNA. The catalytic inactive RNA exosome core complex of 9 subunits (Exo-9) is proposed to play a pivotal role in the binding and presentation of RNA for ribonucleolysis, and to serve as a scaffold for the association with catalytic subunits and accessory proteins or complexes. EXOSC3 as peripheral part of the Exo-9 complex stabilizes the hexameric ring of RNase PH-domain subunits through contacts with EXOSC9 and EXOSC5.

Phenotypes From GWAS Catalog for EXOSC3 Gene

Gene Ontology (GO) - Molecular Function for EXOSC3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000175 3-5-exoribonuclease activity NAS 11110791
GO:0003723 RNA binding IBA --
GO:0004532 NOT exoribonuclease activity IDA 17174896
GO:0005515 protein binding IPI 11719186
genes like me logo Genes that share ontologies with EXOSC3: view
genes like me logo Genes that share phenotypes with EXOSC3: view

Human Phenotype Ontology for EXOSC3 Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Models for EXOSC3 Gene

MGI Knock Outs for EXOSC3:

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for EXOSC3
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Enzyme Numbers (IUBMB) , miRNA , Transcription Factor Targets and HOMER Transcription for EXOSC3 Gene

Localization for EXOSC3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for EXOSC3 Gene

Cytoplasm. Nucleus, nucleolus. Nucleus.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for EXOSC3 gene
Compartment Confidence
nucleus 5
cytosol 5
extracellular 2
mitochondrion 2

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for EXOSC3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000176 nuclear exosome (RNase complex) IDA 11110791
GO:0000177 cytoplasmic exosome (RNase complex) IDA 11110791
GO:0000178 exosome (RNase complex) IDA 20531389
GO:0005634 nucleus IDA,IEA 17545563
GO:0005654 nucleoplasm TAS --
genes like me logo Genes that share ontologies with EXOSC3: view

Pathways & Interactions for EXOSC3 Gene

genes like me logo Genes that share pathways with EXOSC3: view

Pathways by source for EXOSC3 Gene

Gene Ontology (GO) - Biological Process for EXOSC3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000467 exonucleolytic trimming to generate mature 3-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) IBA --
GO:0006364 rRNA processing TAS --
GO:0034427 nuclear-transcribed mRNA catabolic process, exonucleolytic, 3-5 IBA --
GO:0034475 U4 snRNA 3-end processing IBA --
GO:0043488 regulation of mRNA stability TAS --
genes like me logo Genes that share ontologies with EXOSC3: view

No data available for SIGNOR curated interactions for EXOSC3 Gene

Drugs & Compounds for EXOSC3 Gene

No Compound Related Data Available

Transcripts for EXOSC3 Gene

Unigene Clusters for EXOSC3 Gene

Exosome component 3:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for EXOSC3
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for EXOSC3 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b ^ 5a · 5b · 5c
SP1: - -
SP2: - - -
SP3: -
SP4: - -

Relevant External Links for EXOSC3 Gene

GeneLoc Exon Structure for
EXOSC3
ECgene alternative splicing isoforms for
EXOSC3

Expression for EXOSC3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for EXOSC3 Gene

Protein differential expression in normal tissues from HIPED for EXOSC3 Gene

This gene is overexpressed in Breast (8.7) and Pancreas (8.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for EXOSC3 Gene



Protein tissue co-expression partners for EXOSC3 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of EXOSC3 Gene:

EXOSC3

SOURCE GeneReport for Unigene cluster for EXOSC3 Gene:

Hs.602571

Evidence on tissue expression from TISSUES for EXOSC3 Gene

  • Nervous system(5)
  • Skin(4.2)
  • Lung(3.4)
  • Kidney(3)

Phenotype-based relationships between genes and organs from Gene ORGANizer for EXOSC3 Gene

Germ Layers:
  • ectoderm
  • endoderm
  • mesoderm
Systems:
  • digestive
  • nervous
  • respiratory
  • skeletal muscle
  • skeleton
Organs:
Head and neck:
  • brain
  • cerebellum
  • cranial nerve
  • ear
  • eye
  • head
  • jaw
  • mandible
  • maxilla
  • mouth
  • neck
  • skull
  • tongue
Thorax:
  • chest wall
  • clavicle
  • lung
  • rib
  • rib cage
  • scapula
  • sternum
Abdomen:
  • abdominal wall
Pelvis:
  • pelvis
Limb:
  • ankle
  • arm
  • digit
  • elbow
  • femur
  • fibula
  • finger
  • foot
  • forearm
  • hand
  • hip
  • humerus
  • knee
  • lower limb
  • radius
  • shin
  • shoulder
  • thigh
  • tibia
  • toe
  • ulna
  • upper limb
  • wrist
General:
  • peripheral nerve
  • peripheral nervous system
  • spinal column
  • spinal cord
  • vertebrae
genes like me logo Genes that share expression patterns with EXOSC3: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for EXOSC3 Gene

Orthologs for EXOSC3 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for EXOSC3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia EXOSC3 34 33
  • 99.15 (n)
OneToOne
dog
(Canis familiaris)
Mammalia EXOSC3 34 33
  • 90.67 (n)
OneToOne
cow
(Bos Taurus)
Mammalia EXOSC3 34 33
  • 89.33 (n)
OneToOne
rat
(Rattus norvegicus)
Mammalia Exosc3 33
  • 85.58 (n)
mouse
(Mus musculus)
Mammalia Exosc3 33 16 34
  • 84.67 (n)
oppossum
(Monodelphis domestica)
Mammalia EXOSC3 34
  • 83 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia EXOSC3 34
  • 73 (a)
OneToOne
chicken
(Gallus gallus)
Aves EXOSC3 34 33
  • 70.18 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia EXOSC3 34
  • 73 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100491278 33
  • 68.71 (n)
Str.7004 33
African clawed frog
(Xenopus laevis)
Amphibia Xl.24761 33
zebrafish
(Danio rerio)
Actinopterygii exosc3 34 33
  • 66.23 (n)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP010247 33
  • 55.05 (n)
fruit fly
(Drosophila melanogaster)
Insecta Rrp40 34 33
  • 52.2 (n)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea exos-3 33 34
  • 48.78 (n)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0E02091g 33
  • 48.13 (n)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_ADL196W 33
  • 47.14 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes RRP40 33 34 36
  • 46.99 (n)
thale cress
(Arabidopsis thaliana)
eudicotyledons AT2G25355 33
  • 49.17 (n)
rice
(Oryza sativa)
Liliopsida Os01g0661400 33
  • 50.83 (n)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes SPAC22A12.12c 33
  • 49.65 (n)
bread mold
(Neurospora crassa)
Ascomycetes NCU00693 33
  • 46.47 (n)
Species where no ortholog for EXOSC3 was found in the sources mined by GeneCards:
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for EXOSC3 Gene

ENSEMBL:
Gene Tree for EXOSC3 (if available)
TreeFam:
Gene Tree for EXOSC3 (if available)

Paralogs for EXOSC3 Gene

(1) SIMAP similar genes for EXOSC3 Gene using alignment to 1 proteins:

Pseudogenes.org Pseudogenes for EXOSC3 Gene

genes like me logo Genes that share paralogs with EXOSC3: view

No data available for Paralogs for EXOSC3 Gene

Variants for EXOSC3 Gene

Sequence variations from dbSNP and Humsavar for EXOSC3 Gene

SNP ID Clin Chr 09 pos Sequence Context AA Info Type
rs141138948 Pathogenic, Pontocerebellar hypoplasia 1B (PCH1B) [MIM:614678] 37,783,993(+) CAACA(G/T)CAACT reference, missense
rs387907195 Pathogenic, Pontocerebellar hypoplasia 1B (PCH1B) [MIM:614678] 37,783,973(-) AGCCA(C/G)CTTCT reference, missense
rs387907196 Pathogenic, Pontocerebellar hypoplasia 1B (PCH1B) [MIM:614678] 37,784,953(-) CCCGG(C/G)TGAGG reference, missense
rs672601332 Pathogenic, Pontocerebellar hypoplasia 1B (PCH1B) [MIM:614678] 37,780,795(-) GAATA(C/T)GGGTT downstream-variant-500B, reference, missense, utr-variant-3-prime
rs587780333 Pathogenic 37,784,933(-) TGCCG(-/G)AACAG reference, frameshift-variant

Structural Variations from Database of Genomic Variants (DGV) for EXOSC3 Gene

Variant ID Type Subtype PubMed ID
esv3891658 CNV gain 25118596
nsv1125318 OTHER inversion 24896259
nsv469814 CNV gain 16826518
nsv831552 CNV gain 17160897

Variation tolerance for EXOSC3 Gene

Residual Variation Intolerance Score: 80.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.91; 59.38% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for EXOSC3 Gene

Human Gene Mutation Database (HGMD)
EXOSC3
SNPedia medical, phenotypic, and genealogical associations of SNPs for
EXOSC3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for EXOSC3 Gene

Disorders for EXOSC3 Gene

MalaCards: The human disease database

(4) MalaCards diseases for EXOSC3 Gene - From: HGMD, OMIM, ClinVar, GeneTests, Orphanet, Swiss-Prot, DISEASES, and GeneCards

Disorder Aliases PubMed IDs
pontocerebellar hypoplasia, type 1b
  • pontocerebellar hypoplasia type 1b
exosc3-related pontocerebellar hypoplasia
  • pontocerebellar hypoplasia type 1b
pontocerebellar hypoplasia type 1
  • pontocerebellar hypoplasia with anterior horn cell disease
pontocerebellar hypoplasia
  • pch
- elite association - COSMIC cancer census association via MalaCards

UniProtKB/Swiss-Prot

EXOS3_HUMAN
  • Pontocerebellar hypoplasia 1B (PCH1B) [MIM:614678]: A severe autosomal recessive neurologic disorder characterized by a combination of cerebellar and spinal motor neuron degeneration beginning at birth. There is diffuse muscle weakness, progressive microcephaly, global developmental delay, and brainstem involvement. {ECO:0000269 PubMed:22544365}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Relevant External Links for EXOSC3

Genetic Association Database (GAD)
EXOSC3
Human Genome Epidemiology (HuGE) Navigator
EXOSC3
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
EXOSC3
genes like me logo Genes that share disorders with EXOSC3: view

No data available for Genatlas for EXOSC3 Gene

Publications for EXOSC3 Gene

  1. Three novel components of the human exosome. (PMID: 11110791) Brouwer R … Pruijn GJ (The Journal of biological chemistry 2001) 2 3 4 60
  2. Identification of novel human genes evolutionarily conserved in Caenorhabditis elegans by comparative proteomics. (PMID: 10810093) Lai CH … Lin W (Genome research 2000) 2 3 4 60
  3. Zinc-finger antiviral protein inhibits HIV-1 infection by selectively targeting multiply spliced viral mRNAs for degradation. (PMID: 21876179) Zhu Y … Gao G (Proceedings of the National Academy of Sciences of the United States of America 2011) 3 4 60
  4. The RNA exosome targets the AID cytidine deaminase to both strands of transcribed duplex DNA substrates. (PMID: 21255825) Basu U … Alt FW (Cell 2011) 3 4 60
  5. Dis3-like 1: a novel exoribonuclease associated with the human exosome. (PMID: 20531389) Staals RH … Pruijn GJ (The EMBO journal 2010) 3 4 60

Products for EXOSC3 Gene

Sources for EXOSC3 Gene

Content
Loading form....