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Aliases for EXOSC10 Gene

Aliases for EXOSC10 Gene

  • Exosome Component 10 2 3 5
  • P100 Polymyositis-Scleroderma Overlap Syndrome-Associated Autoantigen 3 4
  • Polymyositis/Scleroderma Autoantigen 100 KDa 3 4
  • Polymyositis/Scleroderma Autoantigen 2 3 4
  • PM/Scl-100 3 4
  • PMSCL2 3 4
  • PMSCL 3 4
  • RRP6 3 4
  • Polymyositis/Scleroderma Autoantigen 2 (100kD) 2
  • Polymyositis/Scleroderma Autoantigen 2, 100kDa 2
  • Autoantigen PM/Scl 2 4
  • Autoantigen PM-SCL 3
  • EC 3.1.13.- 4
  • PM-Scl 3
  • Rrp6p 3
  • P3 3
  • P2 3
  • P4 3

External Ids for EXOSC10 Gene

Previous HGNC Symbols for EXOSC10 Gene

  • PMSCL2

Previous GeneCards Identifiers for EXOSC10 Gene

  • GC01M010837
  • GC01M011060
  • GC01M011049
  • GC01M010278

Summaries for EXOSC10 Gene

GeneCards Summary for EXOSC10 Gene

EXOSC10 (Exosome Component 10) is a Protein Coding gene. Diseases associated with EXOSC10 include systemic scleroderma and setx. Among its related pathways are Gene Expression and Pyrimidine metabolism (KEGG). GO annotations related to this gene include nucleic acid binding and nucleotide binding.

UniProtKB/Swiss-Prot for EXOSC10 Gene

  • Putative catalytic component of the RNA exosome complex which has 3->5 exoribonuclease activity and participates in a multitude of cellular RNA processing and degradation events. In the nucleus, the RNA exosome complex is involved in proper maturation of stable RNA species such as rRNA, snRNA and snoRNA, in the elimination of RNA processing by-products and non-coding pervasive transcripts, such as antisense RNA species and promoter-upstream transcripts (PROMPTs), and of mRNAs with processing defects, thereby limiting or excluding their export to the cytoplasm. The RNA exosome may be involved in Ig class switch recombination (CSR) and/or Ig variable region somatic hypermutation (SHM) by targeting AICDA deamination activity to transcribed dsDNA substrates. In the cytoplasm, the RNA exosome complex is involved in general mRNA turnover and specifically degrades inherently unstable mRNAs containing AU-rich elements (AREs) within their 3 untranslated regions, and in RNA surveillance pathways, preventing translation of aberrant mRNAs. It seems to be involved in degradation of histone mRNA. EXOSC10 has 3-5 exonuclease activity (By similarity). EXOSC10 is required for nucleolar localization of C1D and probably mediates the association of SKIV2L2, C1D and MPP6 wth the RNA exosome involved in the maturation of 5.8S rRNA.

Gene Wiki entry for EXOSC10 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for EXOSC10 Gene

Genomics for EXOSC10 Gene

Regulatory Elements for EXOSC10 Gene

Promoters for EXOSC10 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around EXOSC10 on UCSC Golden Path with GeneCards custom track

Genomic Location for EXOSC10 Gene

Chromosome:
1
Start:
11,066,613 bp from pter
End:
11,099,910 bp from pter
Size:
33,298 bases
Orientation:
Minus strand

Genomic View for EXOSC10 Gene

Genes around EXOSC10 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
EXOSC10 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for EXOSC10 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for EXOSC10 Gene

Proteins for EXOSC10 Gene

  • Protein details for EXOSC10 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q01780-EXOSX_HUMAN
    Recommended name:
    Exosome component 10
    Protein Accession:
    Q01780
    Secondary Accessions:
    • B1AKQ0
    • B1AKQ1
    • Q15158

    Protein attributes for EXOSC10 Gene

    Size:
    885 amino acids
    Molecular mass:
    100831 Da
    Quaternary structure:
    • Component of the RNA exosome complex. The catalytically inactive RNA exosome core (Exo-9) complex is believed to associate with catalytic subunits EXOSC10, and DIS3 or DIS3L in cytoplasmic- and nuclear-specific RNA exosome complex forms. Interacts with C1D and MPHOSPH6. Interacts with ALYREF/THOC4.

    Three dimensional structures from OCA and Proteopedia for EXOSC10 Gene

    Alternative splice isoforms for EXOSC10 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for EXOSC10 Gene

Proteomics data for EXOSC10 Gene at MOPED

Post-translational modifications for EXOSC10 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for EXOSC10 Gene

Antibody Products

No data available for DME Specific Peptides for EXOSC10 Gene

Domains & Families for EXOSC10 Gene

Gene Families for EXOSC10 Gene

Protein Domains for EXOSC10 Gene

Suggested Antigen Peptide Sequences for EXOSC10 Gene

Graphical View of Domain Structure for InterPro Entry

Q01780

UniProtKB/Swiss-Prot:

EXOSX_HUMAN :
  • Contains 1 3-5 exonuclease domain.
Domain:
  • Contains 1 3-5 exonuclease domain.
  • Contains 1 HRDC domain.
genes like me logo Genes that share domains with EXOSC10: view

Function for EXOSC10 Gene

Molecular function for EXOSC10 Gene

UniProtKB/Swiss-Prot Function:
Putative catalytic component of the RNA exosome complex which has 3->5 exoribonuclease activity and participates in a multitude of cellular RNA processing and degradation events. In the nucleus, the RNA exosome complex is involved in proper maturation of stable RNA species such as rRNA, snRNA and snoRNA, in the elimination of RNA processing by-products and non-coding pervasive transcripts, such as antisense RNA species and promoter-upstream transcripts (PROMPTs), and of mRNAs with processing defects, thereby limiting or excluding their export to the cytoplasm. The RNA exosome may be involved in Ig class switch recombination (CSR) and/or Ig variable region somatic hypermutation (SHM) by targeting AICDA deamination activity to transcribed dsDNA substrates. In the cytoplasm, the RNA exosome complex is involved in general mRNA turnover and specifically degrades inherently unstable mRNAs containing AU-rich elements (AREs) within their 3 untranslated regions, and in RNA surveillance pathways, preventing translation of aberrant mRNAs. It seems to be involved in degradation of histone mRNA. EXOSC10 has 3-5 exonuclease activity (By similarity). EXOSC10 is required for nucleolar localization of C1D and probably mediates the association of SKIV2L2, C1D and MPP6 wth the RNA exosome involved in the maturation of 5.8S rRNA.

Enzyme Numbers (IUBMB) for EXOSC10 Gene

Gene Ontology (GO) - Molecular Function for EXOSC10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000166 nucleotide binding IEA --
GO:0003676 nucleic acid binding IEA --
GO:0008408 3-5 exonuclease activity IEA --
genes like me logo Genes that share ontologies with EXOSC10: view
genes like me logo Genes that share phenotypes with EXOSC10: view

Animal Model Products

CRISPR Products

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for EXOSC10 Gene

Localization for EXOSC10 Gene

Subcellular locations from UniProtKB/Swiss-Prot for EXOSC10 Gene

Cytoplasm. Nucleus, nucleolus. Nucleus. Note=Strongly enriched in the nucleolus and a small amount has been found in cytoplasm supporting the existence of a nucleolar RNA exosome complex form.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for EXOSC10 Gene COMPARTMENTS Subcellular localization image for EXOSC10 gene
Compartment Confidence
nucleus 5
cytosol 3
extracellular 2

Gene Ontology (GO) - Cellular Components for EXOSC10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000178 exosome (RNase complex) IDA 20531389
GO:0005634 nucleus IDA 17545563
GO:0005654 nucleoplasm TAS --
genes like me logo Genes that share ontologies with EXOSC10: view

Pathways & Interactions for EXOSC10 Gene

genes like me logo Genes that share pathways with EXOSC10: view

Pathways by source for EXOSC10 Gene

1 KEGG pathway for EXOSC10 Gene
1 GeneGo (Thomson Reuters) pathway for EXOSC10 Gene

Gene Ontology (GO) - Biological Process for EXOSC10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000460 maturation of 5.8S rRNA IMP 17412707
GO:0006139 nucleobase-containing compound metabolic process IEA --
GO:0006364 rRNA processing TAS --
GO:0009048 dosage compensation by inactivation of X chromosome IEA --
GO:0071028 nuclear mRNA surveillance IMP 17545563
genes like me logo Genes that share ontologies with EXOSC10: view

No data available for SIGNOR curated interactions for EXOSC10 Gene

Drugs & Compounds for EXOSC10 Gene

No Compound Related Data Available

Transcripts for EXOSC10 Gene

Unigene Clusters for EXOSC10 Gene

Exosome component 10:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for EXOSC10 Gene

No ASD Table

Relevant External Links for EXOSC10 Gene

GeneLoc Exon Structure for
EXOSC10
ECgene alternative splicing isoforms for
EXOSC10

Expression for EXOSC10 Gene

mRNA expression in normal human tissues for EXOSC10 Gene

Protein differential expression in normal tissues from HIPED for EXOSC10 Gene

This gene is overexpressed in Lung (47.8) and Peripheral blood mononuclear cells (7.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for EXOSC10 Gene



SOURCE GeneReport for Unigene cluster for EXOSC10 Gene Hs.632368

genes like me logo Genes that share expression patterns with EXOSC10: view

Protein tissue co-expression partners for EXOSC10 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for EXOSC10 Gene

Orthologs for EXOSC10 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for EXOSC10 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia EXOSC10 35
  • 87.03 (n)
  • 91.79 (a)
EXOSC10 36
  • 89 (a)
OneToOne
dog
(Canis familiaris)
Mammalia EXOSC10 35
  • 86.99 (n)
  • 89.82 (a)
EXOSC10 36
  • 87 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Exosc10 35
  • 83.13 (n)
  • 87.23 (a)
Exosc10 16
Exosc10 36
  • 87 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia EXOSC10 35
  • 99.4 (n)
  • 99.66 (a)
EXOSC10 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Exosc10 35
  • 83.45 (n)
  • 87.33 (a)
oppossum
(Monodelphis domestica)
Mammalia EXOSC10 36
  • 78 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia EXOSC10 36
  • 73 (a)
OneToOne
chicken
(Gallus gallus)
Aves EXOSC10 35
  • 72.71 (n)
  • 74.42 (a)
EXOSC10 36
  • 70 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 81 (a)
OneToMany
-- 36
  • 48 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia exosc10 35
  • 66.9 (n)
  • 67.61 (a)
zebrafish
(Danio rerio)
Actinopterygii exosc10 35
  • 62.24 (n)
  • 62.87 (a)
zgc55695 35
exosc10 36
  • 59 (a)
OneToOne
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.12521 35
fruit fly
(Drosophila melanogaster)
Insecta Rrp6 36
  • 32 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea crn-3 36
  • 29 (a)
OneToOne
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes RRP6 36
  • 30 (a)
OneToOne
RRP6 38
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 47 (a)
OneToOne
Species with no ortholog for EXOSC10:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for EXOSC10 Gene

ENSEMBL:
Gene Tree for EXOSC10 (if available)
TreeFam:
Gene Tree for EXOSC10 (if available)

Paralogs for EXOSC10 Gene

No data available for Paralogs for EXOSC10 Gene

Variants for EXOSC10 Gene

Sequence variations from dbSNP and Humsavar for EXOSC10 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs910660 -- 11,070,586(-) AAAAA(C/T)GTTGC intron-variant
rs910661 -- 11,070,059(-) GATAG(G/T)GGTCT intron-variant
rs1130683 -- 11,072,160(-) AACCG(C/T)TGGAA reference, synonymous-codon
rs1194754 -- 11,080,563(-) TGTGT(G/T)TTTTT intron-variant
rs1194755 -- 11,069,246(+) GTGTG(A/T)GAGAG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for EXOSC10 Gene

Variant ID Type Subtype PubMed ID
dgv137n71 CNV Loss 21882294
nsv870986 CNV Loss 21882294

Variation tolerance for EXOSC10 Gene

Residual Variation Intolerance Score: 50.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.18; 61.83% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for EXOSC10 Gene

HapMap Linkage Disequilibrium report
EXOSC10

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for EXOSC10 Gene

Disorders for EXOSC10 Gene

MalaCards: The human disease database

(6) MalaCards diseases for EXOSC10 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
systemic scleroderma
  • diffuse scleroderma
setx
facial hemiatrophy
  • parry-romberg syndrome
collagen disease
  • collagen disorder
gastric antral vascular ectasia
  • watermelon stomach
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for EXOSC10

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
EXOSC10
genes like me logo Genes that share disorders with EXOSC10: view

No data available for UniProtKB/Swiss-Prot and Genatlas for EXOSC10 Gene

Publications for EXOSC10 Gene

  1. Cloning and characterization of the cDNA coding for a polymyositis- scleroderma overlap syndrome-related nucleolar 100-kD protein. (PMID: 1383382) Bluethner M. … Bautz F.A. (J. Exp. Med. 1992) 2 3 4 67
  2. Cloning of a complementary DNA coding for the 100-kD antigenic protein of the PM-Scl autoantigen. (PMID: 1644924) Ge Q. … Targoff I.N. (J. Clin. Invest. 1992) 2 3
  3. Temporal proteomics of NGF-TrkA signaling identifies an inhibitory role for the E3 ligase Cbl-b in neuroblastoma cell differentiation. (PMID: 25921289) Emdal K.B. … Olsen J.V. (Sci Signal 2015) 3
  4. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  5. Panorama of ancient metazoan macromolecular complexes. (PMID: 26344197) Wan C. … Emili A. (Nature 2015) 3

Products for EXOSC10 Gene

Sources for EXOSC10 Gene

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