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EXOSC10 Gene

protein-coding   GIFtS: 59
GCID: GC01M011126

Exosome Component 10

(Previous names: polymyositis/scleroderma autoantigen 2, 100kDa)
(Previous symbol: PMSCL2)
  See EXOSC10-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Exosome Component 101 2     P100 Polymyositis-Scleroderma Overlap Syndrome-Associated Autoantigen2 3
PMSCL21 2 3 5     PM-Scl2
Polymyositis/Scleroderma Autoantigen 2, 100kDa1 2     Rrp6p2
Polymyositis/Scleroderma Autoantigen 2 (100kD)1 2     Autoantigen PM-SCL2
Autoantigen PM/Scl 22 3     p22
Polymyositis/Scleroderma Autoantigen 100 KDa2 3     p32
PM/Scl-1002 3     p42
PMSCL2 3     EC 3.1.13.-3
RRP62 3     Polymyositis/Scleroderma Autoantigen 23

External Ids:    HGNC: 91381   Entrez Gene: 53942   Ensembl: ENSG000001718247   OMIM: 6059605   UniProtKB: Q017803   

Export aliases for EXOSC10 gene to outside databases

Previous GC identifers: GC01M010837 GC01M011060 GC01M011049 GC01M010278


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for EXOSC10 Gene:
EXOSC10 (exosome component 10) is a protein-coding gene. Diseases associated with EXOSC10 include polymyositis, and scleroderma. GO annotations related to this gene include 3'-5' exonuclease activity and RNA binding.

UniProtKB/Swiss-Prot: EXOSX_HUMAN, Q01780
Function: Putative catalytic component of the RNA exosome complex which has 3'->5' exoribonuclease activity and
participates in a multitude of cellular RNA processing and degradation events. In the nucleus, the RNA exosome
complex is involved in proper maturation of stable RNA species such as rRNA, snRNA and snoRNA, in the elimination
of RNA processing by-products and non-coding 'pervasive' transcripts, such as antisense RNA species and
promoter-upstream transcripts (PROMPTs), and of mRNAs with processing defects, thereby limiting or excluding
their export to the cytoplasm. The RNA exosome may be involved in Ig class switch recombination (CSR) and/or Ig
variable region somatic hypermutation (SHM) by targeting AICDA deamination activity to transcribed dsDNA
substrates. In the cytoplasm, the RNA exosome complex is involved in general mRNA turnover and specifically
degrades inherently unstable mRNAs containing AU-rich elements (AREs) within their 3' untranslated regions, and
in RNA surveillance pathways, preventing translation of aberrant mRNAs. It seems to be involved in degradation of
histone mRNA. EXOSC10 has 3'-5' exonuclease activity (By similarity). EXOSC10 is required for nucleolar
localization of C1D and probably mediates the association of SKIV2L2, C1D and MPP6 wth the RNA exosome involved
in the maturation of 5.8S rRNA

Gene Wiki entry for EXOSC10 (Exosome component 10) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000001.10  NT_032977.10  NC_018912.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the EXOSC10 gene promoter:
         RFX1   AML1a   HTF   POU3F2   LCR-F1   Evi-1   HNF-1A   E47   HNF-1   Hand1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidEXOSC10 promoter sequence
   Search Chromatin IP Primers for EXOSC10

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat EXOSC10


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1p36.22   Ensembl cytogenetic band:  1p36.22   HGNC cytogenetic band: 1p36.22

EXOSC10 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
EXOSC10 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01M011126:  view genomic region     (about GC identifiers)

Start:
11,126,675 bp from pter      End:
11,159,938 bp from pter
Size:
33,264 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: EXOSX_HUMAN, Q01780 (See protein sequence)
Recommended Name: Exosome component 10  
Size: 885 amino acids; 100831 Da
Subunit: Component of the RNA exosome complex. The catalytically inactive RNA exosome core (Exo-9) complex is
believed to associate with catalytic subunits EXOSC10, and DIS3 or DIS3L in cytoplasmic- and nuclear-specific RNA
exosome complex forms. Interacts with C1D and MPHOSPH6. Interacts with ALYREF/THOC4
4 PDB 3D structures from and Proteopedia for EXOSC10:
2CPR (3D)        3SAF (3D)        3SAG (3D)        3SAH (3D)    
Secondary accessions: B1AKQ0 B1AKQ1 Q15158
Alternative splicing: 2 isoforms:  Q01780-1   Q01780-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for EXOSC10: NX_Q01780

Explore proteomics data for EXOSC10 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See EXOSC10 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001001998.1  NP_002676.1  

    ENSEMBL proteins: 
     ENSP00000307307   ENSP00000366135   ENSP00000465008   ENSP00000439473  

    EXOSC10 Human Recombinant Protein Products:

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    OriGene Protein Over-expression Lysate for EXOSC10
    OriGene Custom MassSpec
    OriGene Custom Protein Services for EXOSC10
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    Novus Biologicals EXOSC10 Proteins
    Novus Biologicals EXOSC10 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    ProSpec Recombinant Protein for EXOSC10
    Cloud-Clone Corp. Proteins for EXOSC10

     
    Search eBioscience for Proteins for EXOSC10 

    EXOSC10 Antibody Products:

    EMD Millipore Mono- and Polyclonal Antibodies for the study of EXOSC10
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    Browse OriGene Antibodies
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    Novus Biologicals EXOSC10 Antibodies
    Abcam antibodies for EXOSC10
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    ThermoFisher Antibodies for EXOSC10
    LSBio Antibodies in human, mouse, rat for EXOSC10

    EXOSC10 Assay Products:

    Browse Kits and Assays available from EMD Millipore
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    GenScript Custom Assay Services for EXOSC10
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for EXOSC10
    Cloud-Clone Corp. CLIAs for EXOSC10
    Search eBioscience for ELISAs for EXOSC10 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    5 InterPro protein domains:
     IPR012588 Exosome-assoc_fac_Rrp6_N
     IPR010997 HRDC-like
     IPR002562 3'-5'_exonuclease_dom
     IPR012337 RNaseH-like_dom
     IPR002121 HRDC_dom

    Graphical View of Domain Structure for InterPro Entry Q01780

    ProtoNet protein and cluster: Q01780

    2 Blocks protein domains:
    IPB002562 3'-5' exonuclease
    IPB012588 PMC2NT


    UniProtKB/Swiss-Prot: EXOSX_HUMAN, Q01780
    Similarity: Contains 1 3'-5' exonuclease domain
    Similarity: Contains 1 HRDC domain


    Find genes that share domains with EXOSC10           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: EXOSX_HUMAN, Q01780
    Function: Putative catalytic component of the RNA exosome complex which has 3'->5' exoribonuclease activity and
    participates in a multitude of cellular RNA processing and degradation events. In the nucleus, the RNA exosome
    complex is involved in proper maturation of stable RNA species such as rRNA, snRNA and snoRNA, in the elimination
    of RNA processing by-products and non-coding 'pervasive' transcripts, such as antisense RNA species and
    promoter-upstream transcripts (PROMPTs), and of mRNAs with processing defects, thereby limiting or excluding
    their export to the cytoplasm. The RNA exosome may be involved in Ig class switch recombination (CSR) and/or Ig
    variable region somatic hypermutation (SHM) by targeting AICDA deamination activity to transcribed dsDNA
    substrates. In the cytoplasm, the RNA exosome complex is involved in general mRNA turnover and specifically
    degrades inherently unstable mRNAs containing AU-rich elements (AREs) within their 3' untranslated regions, and
    in RNA surveillance pathways, preventing translation of aberrant mRNAs. It seems to be involved in degradation of
    histone mRNA. EXOSC10 has 3'-5' exonuclease activity (By similarity). EXOSC10 is required for nucleolar
    localization of C1D and probably mediates the association of SKIV2L2, C1D and MPP6 wth the RNA exosome involved
    in the maturation of 5.8S rRNA

         Enzyme Number (IUBMB): EC 3.1.13.-1

         Gene Ontology (GO): Selected molecular function terms (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000166nucleotide binding IEA--
    GO:0003676nucleic acid binding ----
    GO:0003723RNA binding ----
    GO:0003824catalytic activity ----
    GO:0004532exoribonuclease activity IDA17174896
         
    Find genes that share ontologies with EXOSC10           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for EXOSC10:
     Synthetic lethal with Ras 

         1 MGI mutant phenotype (inferred from 1 allele(MGI details for Exosc10):
     normal 

    Find genes that share phenotypes with EXOSC10           About GenesLikeMe

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for EXOSC10
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for EXOSC10

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for EXOSC10
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for EXOSC10

    miRNA
    Products:
        
    miRTarBase miRNAs that target EXOSC10:
    hsa-mir-193b-3p (MIRT041296), hsa-mir-30a-5p (MIRT028551), hsa-mir-484 (MIRT041716), hsa-mir-222-3p (MIRT046671)

    Block miRNA regulation of human, mouse, rat EXOSC10 using miScript Target Protectors
    Search for qRT-PCR Assays for microRNAs that regulate EXOSC10
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for EXOSC10
    Predesigned siRNA for gene silencing in human, mouse, rat EXOSC10

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for EXOSC10

    Clone
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    GenScript: all cDNA clones in your preferred vector (see all 2): EXOSC10 (NM_001001998)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for EXOSC10
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat EXOSC10
    Addgene plasmids for EXOSC10 

    Cell Line
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    GenScript Custom overexpressing Cell Line Services for EXOSC10
    Browse ESI BIO Cell Lines and PureStem Progenitors for EXOSC10 
    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for EXOSC10


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    EXOSX_HUMAN, Q01780: Cytoplasm. Nucleus, nucleolus. Nucleus. Note=Strongly enriched in the nucleolus and a small
    amount has been found in cytoplasm supporting the existence of a nucleolar RNA exosome complex form
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    cytosol3

    Gene Ontology (GO): Selected cellular component terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000176nuclear exosome (RNase complex) IEA--
    GO:0000178exosome (RNase complex) IDA--
    GO:0005622intracellular ----
    GO:0005634nucleus IDA--
    GO:0005730nucleolus IDA--

    Find genes that share ontologies with EXOSC10           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for EXOSC10 About    
    See pathways by source

    SuperPathContained pathways About
    1Deadenylation-dependent mRNA decay
    RNA degradation0.48
    2Purine metabolism (KEGG)
    ATP ITP metabolism0.31


    Find genes that share SuperPaths with EXOSC10           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 GeneGo (Thomson Reuters) Pathway for EXOSC10
        ATP/ITP metabolism


    1 Kegg Pathway  (Kegg details for EXOSC10):
        RNA degradation

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for EXOSC10
    Interactions:

        Search GeneGlobe Interaction Network for EXOSC10

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for EXOSC10 (Q017801, 2, 3 ENSP000003661354) via UniProtKB, MINT, STRING, and/or I2D (see all 1166)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    DDX39BQ138382, 3, ENSP000003794754MINT-7945693 MINT-7947479 I2D: score=1 STRING: ENSP00000379475
    ENSG00000225073Q138382, 3, ENSP000004003264MINT-7945693 MINT-7947479 I2D: score=1 STRING: ENSP00000400326
    DIS3Q9Y2L11, 2, 3, ENSP000003669974EBI-358236,EBI-373539 MINT-7993717 MINT-7994058 I2D: score=8 STRING: ENSP00000366997
    ENSG00000215425Q138382, 3MINT-7945693 MINT-7947479 I2D: score=1 
    ENSG00000225859Q138382, 3MINT-7945693 MINT-7947479 I2D: score=1 
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 13):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000184nuclear-transcribed mRNA catabolic process, nonsense-mediated decay IMP--
    GO:0000460maturation of 5.8S rRNA IMP17412707
    GO:0000956nuclear-transcribed mRNA catabolic process IMP17545563
    GO:0006139nucleobase-containing compound metabolic process ----
    GO:0006396RNA processing ----

    Find genes that share ontologies with EXOSC10           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for EXOSC10 (EXOSX)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for EXOSC10 gene (2 alternative transcripts): 
    NM_001001998.1  NM_002685.2  

    Unigene Cluster for EXOSC10:

    Exosome component 10
    Hs.632368  [show with all ESTs]
    Unigene Representative Sequence: AB209236
    12 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000304457 ENST00000376936(uc001asa.3 uc001asb.3 uc009vmy.1)
    ENST00000474216 ENST00000490565 ENST00000469634 ENST00000478271 ENST00000470611
    ENST00000498576 ENST00000472078 ENST00000485606 ENST00000460196 ENST00000544779

    miRNA
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    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat EXOSC10
    Clone
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    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): EXOSC10 (NM_001001998)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for EXOSC10
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat EXOSC10
    Addgene plasmids for EXOSC10 
    Primer
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    OriGene qSTAR qPCR primer pairs in human, mouse for EXOSC10
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat EXOSC10
      QuantiTect SYBR Green Assays in human, mouse, rat EXOSC10
      QuantiFast Probe-based Assays in human, mouse, rat EXOSC10

    Additional mRNA sequence: 

    AB209236.1 AK123365.1 AK294058.1 AK308778.1 BC008460.1 BC009908.2 BC028687.1 BC039901.1 
    BC073788.1 L01457.1 X66113.1 

    23 DOTS entries:

    DT.75148510  DT.100820127  DT.100820126  DT.100700929  DT.95150878  DT.95247143  DT.87015173  DT.121442943 
    DT.118752  DT.97854074  DT.40128079  DT.121442942  DT.121442954  DT.40287363  DT.100820124  DT.100820128 
    DT.121442879  DT.121442934  DT.75132711  DT.91799980  DT.92451033  DT.95319919  DT.99952575 

    Selected AceView cDNA sequences (see all 437):

    BQ009942 AA595205 CA395610 BM827667 BC073788 BM992425 CD742583 AA373477 
    CA396661 BU507323 BI861125 AA312604 AW575464 CA307576 BM738337 BG253165 
    BG168036 AL040895 AU279902 H97680 CR594914 NM_001001998 BU616202 BP350077 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    EXOSC10 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TCCTTTCCAA
    EXOSC10 Expression
    About this image


    EXOSC10 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 7) fully expand
     
     Heart (Cardiovascular System)    fully expand to see all 2 entries
             Atrioventricular Canal Cells Atrioventricular Canal
             Outflow Tract
     
     Brain (Nervous System)    fully expand to see all 2 entries
             Cerebral Cortex
     
     Trophoblast (Extraembryonic Tissues)
             Trophoblast Cells Trophoblast
     
     Ovary (Reproductive System)
             Oviduct
     
     Pancreas (Endocrine System)
             Islets of Langerhans
    EXOSC10 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    EXOSC10 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.632368
        Custom PCR Arrays for EXOSC10
    Primer
    Products:
    OriGene qPCR primer pairs and template standards for EXOSC10
    OriGene qSTAR qPCR primer pairs in human, mouse for EXOSC10
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat EXOSC10
    QuantiTect SYBR Green Assays in human, mouse, rat EXOSC10
    QuantiFast Probe-based Assays in human, mouse, rat EXOSC10
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for EXOSC10

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for EXOSC10 gene from Selected species (see all 18)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Exosc101 , 5 exosome component 101, 5 83.13(n)1
    87.23(a)1
      4 (78.76 cM)5
    509121  NM_016699.21  NP_057908.21 
     1485584295 
    chicken
    (Gallus gallus)
    Aves EXOSC101 exosome component 10 72.71(n)
    74.42(a)
      419454  NM_001012730.2  NP_001012748.1 
    lizard
    (Anolis carolinensis)
    Reptilia --
    --
    Uncharacterized protein
    81(a)
    48(a)
    many → 1
    many → 1
    AAWZ02038788(2764-10411)
    GL343615.1(98087-108325)
    African clawed frog
    (Xenopus laevis)
    Amphibia BJ060757.12   -- 75.48(n)    BJ060757.1 
    zebrafish
    (Danio rerio)
    Actinopterygii zgc556952 similar to polymyositis/scleroderma autoantigen 2 74.88(n)   394064  BC045429.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Rrp66
    Rrp6
    32(a)
    1 ↔ 1
    3R(10708105-10711918)
    worm
    (Caenorhabditis elegans)
    Secernentea crn-36
    Protein CRN-3, isoform a (crn-3) mRNA, complete cd...
    29(a)
    1 ↔ 1
    II(10588042-10592653) WBGene00000796
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes RRP6(YOR001W)4 Nuclear exosome exonuclease component; has 3'-5' exonuclease more   --   15(326832-329033) 854162  NP_014643.1 
    rice
    (Oryza sativa)
    Liliopsida AK067375.12   -- 71.08(n)    AK067375.1 


    ENSEMBL Gene Tree for EXOSC10 (if available)
    TreeFam Gene Tree for EXOSC10 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

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    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

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    Selected SNPs for EXOSC10 (see all 962)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs783496431,2
    C,F--11126223(+) AATGAT/CTAAAA 2 -- int12Minor allele frequency- C:0.04WA 120
    rs27916611,2
    C,F,A--11126399(-) TAGCCA/GGGCAT 2 -- int14Minor allele frequency- G:0.25NA CSA 8
    rs27488801,2
    C,F,A--11126432(-) TGAAAG/CCCTTT 2 -- int14Minor allele frequency- C:0.20NA CSA WA 124
    rs1930396531,2
    --11126440(+) TCACCA/GTGTTG 2 -- int10--------
    rs27488791,2
    C,F,A--11126490(-) GAGGCC/TGAGGC 2 -- int14Minor allele frequency- T:0.25NA CSA 8
    rs27916601,2
    C,F,A--11126517(-) CTCACA/GCCTGC 2 -- int15Minor allele frequency- G:0.20NA CSA 10
    rs27916591,2
    C,F,A,H--11126569(-) CCGGGT/GGTTAT 2 -- int19Minor allele frequency- G:0.40NA CSA WA EA 372
    rs1852958971,2
    --11126573(+) CCCCCA/GGAGCA 2 -- int10--------
    rs412744981,2
    C,F--11126697(+) TTAATG/CGTTTA 2 -- ut311Minor allele frequency- C:0.04EA 120
    rs31899171,2
    C--11126709(-) CATACA/GTATTT 2 -- ut31 ese30--------

    HapMap Linkage Disequilibrium report for EXOSC10 (11126675 - 11159938 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for EXOSC10:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv870986CNV Loss21882294
    dgv137n71CNV Loss21882294

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing EXOSC10
    DNA2.0 Custom Variant and Variant Library Synthesis for EXOSC10

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 605960    OMIM disorders: --

    2 diseases for EXOSC10:    
    About MalaCards
    polymyositis    scleroderma


    Find genes that share disorders with EXOSC10           About GenesLikeMe


    Export disorders for EXOSC10 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for EXOSC10 gene, integrated from 10 sources (see all 56):
    (articles sorted by number of sources associating them with EXOSC10)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Cloning of a complementary DNA coding for the 100-kD antigenic protein of the PM-Scl autoantigen. (PubMed id 1644924)1, 2, 3 Ge Q.... Targoff I.N. (J. Clin. Invest. 1992)
    2. Cloning and characterization of the cDNA coding for a polymyositis- scleroderma overlap syndrome-related nucleolar 100-kD protein. (PubMed id 1383382)1, 2, 3 Bluethner M. and Bautz F.A. (J. Exp. Med. 1992)
    3. Dis3-like 1: a novel exoribonuclease associated with the human exosome. (PubMed id 20531389)1, 2 Staals R.H.... Pruijn G.J. (EMBO J. 2010)
    4. The human core exosome interacts with differentially localized processive RNases: hDIS3 and hDIS3L. (PubMed id 20531386)1, 2 Tomecki R.... Jensen T.H. (EMBO J. 2010)
    5. RNA exosome depletion reveals transcription upstream of active human promoters. (PubMed id 19056938)1, 2 Preker P.... Jensen T.H. (Science 2008)
    6. Degradation of histone mRNA requires oligouridylation followed by decapping and simultaneous degradation of the mRNA both 5' to 3' and 3' to 5'. (PubMed id 18172165)1, 2 Mullen T.E. and Marzluff W.F. (Genes Dev. 2008)
    7. Human cell growth requires a functional cytoplasmic exosome, which is involved in various mRNA decay pathways. (PubMed id 17545563)1, 2 van Dijk E.L.... Pruijn G.J. (RNA 2007)
    8. C1D and hMtr4p associate with the human exosome subunit PM/Scl-100 and are involved in pre-rRNA processing. (PubMed id 17412707)1, 2 Schilders G.... Pruijn G.J.M. (Nucleic Acids Res. 2007)
    9. Adenylation and exosome-mediated degradation of cotranscriptionally cleaved pre-messenger RNA in human cells. (PubMed id 16455498)1, 2 West S.... Proudfoot N.J. (Mol. Cell 2006)
    10. A protein interaction framework for human mRNA degradation. (PubMed id 15231747)1, 2 Lehner B. and Sanderson C.M. (Genome Res. 2004)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 5394 HGNC: 9138 AceView: EXOSC10 Ensembl:ENSG00000171824 euGenes: HUgn5394
    ECgene: EXOSC10 Kegg: 5394 H-InvDB: EXOSC10

    (According to HUGE)
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    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for EXOSC10 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for EXOSC10 gene:
    Search GeneIP for patents involving EXOSC10

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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