EXOSC10 Gene
protein-coding GIFtS: 56
GCID: GC01M011126
|
|
exosome component 10(Previous names: polymyositis/scleroderma autoantigen 2, 100kDa )
(Previous symbol: PMSCL2)
| |
Aliases
for EXOSC10 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Exosome Component 101 2 | | Polymyositis/Scleroderma Autoantigen 2, 100kDa1 2 | | PMSCL21 2 3 5 | | Autoantigen PM/Scl 22 3 | | PM/Scl-1001 2 3 | | Polymyositis/Scleroderma Autoantigen 100 KDa2 3 | | RRP61 2 3 | | PMSCL2 3 | | PM-Scl1 2 | | P100 Polymyositis-Scleroderma Overlap Syndrome-Associated Autoantigen2 3 | | Rrp6p1 2 | | Autoantigen PM-SCL2 | | P21 | | Polymyositis/Scleroderma Autoantigen 2 (100kD)2 | | P31 | | EC 3.1.13.-3 | | P41 | | Polymyositis/Scleroderma Autoantigen 23 |
Export aliases for EXOSC10 gene to outside databasesPrevious GC identifers: GC01M010837 GC01M011060 GC01M011049 GC01M010278 |
Summaries
for EXOSC10 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
UniProtKB/Swiss-Prot: EXOSX_HUMAN, Q01780Function: Putative catalytic component of the RNA exosome complex which has 3'->5' exoribonuclease activity andparticipates in a multitude of cellular RNA processing and degradation events. In the nucleus, the RNA exosome complexis involved in proper maturation of stable RNA species such as rRNA, snRNA and snoRNA, in the elimination of RNAprocessing by-products and non-coding 'pervasive' transcripts, such as antisense RNA species and promoter-upstreamtranscripts (PROMPTs), and of mRNAs with processing defects, thereby limiting or excluding their export to thecytoplasm. The RNA exosome may be involved in Ig class switch recombination (CSR) and/or Ig variable region somatichypermutation (SHM) by targeting AICDA deamination activity to transcribed dsDNA substrates. In the cytoplasm, the RNAexosome complex is involved in general mRNA turnover and specifically degrades inherently unstable mRNAs containingAU-rich elements (AREs) within their 3' untranslated regions, and in RNA surveillance pathways, preventing translationof aberrant mRNAs. It seems to be involved in degradation of histone mRNA. EXOSC10 has 3'-5' exonuclease activity (Bysimilarity). EXOSC10 is required for nucleolar localization of C1D and probably mediates the association of SKIV2L2,C1D and MPP6 wth the RNA exosome involved in the maturation of 5.8S rRNA
Gene Wiki entry for EXOSC10 (Exosome component 10)
|
Genomic Views
for EXOSC10 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000001.10 NC_018912.1 NT_021937.19
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the EXOSC10 gene promoter:
RFX1 AML1a HTF POU3F2 LCR-F1 Evi-1 HNF-1A E47 HNF-1 Hand1
Other transcription factors
Search SABiosciences Chromatin IP Primers for EXOSC10
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat EXOSC10 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 1p36.22 Ensembl cytogenetic band: 1p36.22 HGNC cytogenetic band: 1p36.22EXOSC10 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 1 GeneLoc Exon Structure GeneLoc location for GC01M011126: view genomic region
(about GC identifiers)
Start:
|
11,126,675 bp from pter |
End:
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11,159,938 bp from pter |
Size:
|
33,264 bases |
Orientation:
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minus strand |
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Proteins
for EXOSC10 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: EXOSX_HUMAN, Q01780 (See
protein sequence)Recommended Name: Exosome component 10 Size: 885 amino acids; 100831 Da
Subunit: Component of the RNA exosome complex. The catalytically inactive RNA exosome core (Exo-9) complex is believedto associate with catalytic subunits EXOSC10, and DIS3 or DIS3L in cytoplasmic- and nuclear-specific RNA exosomecomplex forms. Interacts with C1D and MPHOSPH6
Subcellular location: Cytoplasm. Nucleus, nucleolus. Nucleus. Note=Strongly enriched in the nucleolus and a smallamount has been found in cytoplasm supporting the existence of a nucleolar RNA exosome complex form
4 PDB 3D structures from  and Proteopedia  for EXOSC10:2CPR (3D)
3SAF (3D)
3SAG (3D)
3SAH (3D)
Secondary accessions: B1AKQ0 B1AKQ1 Q15158Alternative splicing: 2 isoforms: Q01780-1 Q01780-2 (No experimental confirmation available)Explore the universe of human proteins at neXtProt for EXOSC10: NX_Q01780
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q01780
EXOSC10 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (2 alternative transcripts):
NP_001001998.1 NP_002676.1
ENSEMBL proteins: ENSP00000307307 ENSP00000366135 ENSP00000465008 ENSP00000439473
Human Recombinant Protein Products:
Gene Ontology (GO): 5/6 cellular component terms (GO ID links to tree view) (see all 6): About this table
EXOSC10 for ontologies About GeneDecksing
EXOSC10 Antibody Products:
Assay Products for EXOSC10: |
Protein
Domains /
Families
for EXOSC10 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
EXOSC10 for domains About GeneDecksing
5 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q01780ProtoNet protein and cluster: Q01780 2 Blocks protein families: IPB002562 3'-5' exonuclease IPB012588 PMC2NT
UniProtKB/Swiss-Prot: EXOSX_HUMAN, Q01780Similarity: Contains 1 3'-5' exonuclease domainSimilarity: Contains 1 HRDC domain |
Function
for EXOSC10 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: EXOSX_HUMAN, Q01780Function: Putative catalytic component of the RNA exosome complex which has 3'->5' exoribonuclease activity andparticipates in a multitude of cellular RNA processing and degradation events. In the nucleus, the RNA exosome complexis involved in proper maturation of stable RNA species such as rRNA, snRNA and snoRNA, in the elimination of RNAprocessing by-products and non-coding 'pervasive' transcripts, such as antisense RNA species and promoter-upstreamtranscripts (PROMPTs), and of mRNAs with processing defects, thereby limiting or excluding their export to thecytoplasm. The RNA exosome may be involved in Ig class switch recombination (CSR) and/or Ig variable region somatichypermutation (SHM) by targeting AICDA deamination activity to transcribed dsDNA substrates. In the cytoplasm, the RNAexosome complex is involved in general mRNA turnover and specifically degrades inherently unstable mRNAs containingAU-rich elements (AREs) within their 3' untranslated regions, and in RNA surveillance pathways, preventing translationof aberrant mRNAs. It seems to be involved in degradation of histone mRNA. EXOSC10 has 3'-5' exonuclease activity (Bysimilarity). EXOSC10 is required for nucleolar localization of C1D and probably mediates the association of SKIV2L2,C1D and MPP6 wth the RNA exosome involved in the maturation of 5.8S rRNAEnzyme Number (IUBMB): EC 3.1.13.-1
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for EXOSC10 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for EXOSC10 (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector (see all 2): EXOSC10 (NM_001001998) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for EXOSC10 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat EXOSC10 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for EXOSC10 |
Gene Ontology (GO): 5/6 molecular function terms (GO ID links to tree view) (see all 6): About this table
EXOSC10 for ontologies About GeneDecksing
1 GenomeRNAi human phenotype for EXOSC10:
|
Pathways & Interactions
for EXOSC10 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | ATP/ITP metabolism | | | 2 | Deadenylation-dependent mRNA decay | |
Pathway sources
See GeneCards unified pathways
Show all pathways
1 EMD Millipore Pathway for EXOSC10
1  GeneGo (Thomson Reuters) Pathway for EXOSC10
1 
Kegg Pathway (Kegg details for EXOSC10):
EXOSC10 for pathways About GeneDecksing
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for EXOSC10
STRING Interaction
Network Preview (showing 5 interactants - click image to see 25)
5/902 Interacting proteins for EXOSC10 (Q017801, 2, 3 ENSP000003661354) via UniProtKB, MINT, STRING, and/or I2D (see all 902)| Interactant | Interaction Details |
|---|
| GeneCard | External ID(s) |
|---|
| EXOSC2 | Q138682, 3, ENSP000003614334 | MINT-7993644 MINT-7993837 MINT-7988296 MINT-7993717 I2D:
score=6 STRING: ENSP00000361433 | | EXOSC3 | Q9NQT52, 3, ENSP000003230464 | MINT-7993644 MINT-7993837 MINT-7988296 MINT-7994058 I2D:
score=5 STRING: ENSP00000323046 | | EXOSC6 | Q5RKV62, 3, ENSP000003985974 | MINT-7993644 MINT-7945693 MINT-7993837 MINT-7988296 I2D:
score=2 STRING: ENSP00000398597 | | DIS3 | Q9Y2L12, 3, ENSP000003669974 | MINT-7993717 MINT-7994058 I2D:
score=8 STRING: ENSP00000366997 | | UPF2 | Q9HAU52, 3, ENSP000003487084 | MINT-7945693 MINT-7947479 I2D:
score=4 STRING: ENSP00000348708 |
About this table
Gene Ontology (GO): 5/10 biological process terms (GO ID links to tree view) (see all 10): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0000184 | nuclear-transcribed mRNA catabolic process, nonsense-mediated decay |
IMP | -- | | GO:0000460 | maturation of 5.8S rRNA |
IMP | 17412707 | | GO:0000956 | nuclear-transcribed mRNA catabolic process |
IMP | 17545563 | | GO:0006396 | RNA processing |
-- | -- | | GO:0009048 | dosage compensation by inactivation of X chromosome |
IEA | -- |
EXOSC10 for ontologies About GeneDecksing
|
Drugs & Compounds
for EXOSC10 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for EXOSC10
Search CenterWatch for drugs/clinical trials and news about EXOSC10 / EXOSX
|
Transcripts
for EXOSC10 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for EXOSC10 gene (2 alternative transcripts): NM_001001998.1 NM_002685.2 Unigene Cluster for EXOSC10: Exosome component 10 Hs.632368 [show with all ESTs]Unigene Representative Sequence: AB20923612 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000304457 ENST00000376936(uc001asa.3 uc001asb.3 uc009vmy.1)
ENST00000474216 ENST00000490565 ENST00000469634 ENST00000478271 ENST00000470611
ENST00000498576 ENST00000472078 ENST00000485606 ENST00000460196 ENST00000544779
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for EXOSC10 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for EXOSC10 (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector (see all 2): EXOSC10 (NM_001001998) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for EXOSC10 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat EXOSC10 |
Additional cDNA sequence: AB209236.1 AK123365.1 AK294058.1 AK296559.1 AK308778.1 BC008460.1 BC009908.2 BC028687.1 BC039901.1 BC073788.1 L01457.1 X66113.1 23 DOTS entries: DT.75148510 DT.100820127 DT.100820126 DT.100700929 DT.95150878 DT.95247143 DT.87015173 DT.121442943 DT.118752 DT.97854074 DT.40128079 DT.121442942 DT.121442954 DT.40287363 DT.100820124 DT.100820128 DT.121442879 DT.121442934 DT.75132711 DT.91799980 DT.92451033 DT.95319919 DT.99952575 24/437 AceView cDNA sequences (see all 437): AU102258 AW575464 NM_001001998 BG253165 BQ068935 BP346450 BP345767 BC028687 AW247347 BM992425 CA867932 BP350077 CD742583 BU677769 AA744726 L01457 AA595205 BF434115 BX350371 BM738337 AL602551 AL135133 NM_002685 BM834075
GeneLoc Exon Structure
|
Expression
for EXOSC10 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| EXOSC10 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TCCTTTCCAA
About this image
See EXOSC10 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for EXOSC10
SOURCE GeneReport for Unigene cluster: Hs.632368
SABiosciences Custom PCR Arrays for EXOSC10
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for EXOSC10
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat EXOSC10 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat EXOSC10 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat EXOSC10 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for EXOSC10 |
Orthologs
for EXOSC10 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the last universal common ancestor (LUCA).
Orthologs for EXOSC10 gene from 10/28 species (see all 28) About this table
ENSEMBL Gene Tree for EXOSC10 (if available)
TreeFam Gene Tree for EXOSC10 (if available) |
Paralogs
for EXOSC10 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| -- |
Genomic Variants
for EXOSC10 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 1 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for EXOSC10 (11126675 - 11159938 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for EXOSC10: -- | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing EXOSC10 |
|
Disorders
/ Diseases
for EXOSC10 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
EXOSC10 for disorders About GeneDecksing
OMIM gene information: 605960
OMIM disorders: --
5  diseases for EXOSC10: About MalaCardspolymyositis scleroderma systemic scleroderma dermatomyositis
malaria
Export disorders for EXOSC10 gene to outside databases
|
Publications
for EXOSC10 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for EXOSC10 gene, integrated from 9 sources (see all 52):
(articles sorted by number of sources associating them with EXOSC10) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Cloning of a complementary DNA coding for the 100-kD antigenic protein of the PM-Scl autoantigen. (PubMed id 1644924)1, 2, 3 Ge Q.... Targoff I.N. (1992)
- Cloning and characterization of the cDNA coding for a polymyositis- scleroderma overlap syndrome-related nucleolar 100-kD protein. (PubMed id 1383382)1, 2, 3 Bluethner M. and Bautz F.A. (1992)
- Dis3-like 1: a novel exoribonuclease associated with the human exosome. (PubMed id 20531389)1, 2 Staals R.H....Pruijn G.J. (2010)
- The human core exosome interacts with differentially localized processive RNases: hDIS3 and hDIS3L. (PubMed id 20531386)1, 2 Tomecki R....Jensen T.H. (2010)
- RNA exosome depletion reveals transcription upstream of active human promoters. (PubMed id 19056938)1, 2 Preker P.... Jensen T.H. (2008)
- Degradation of histone mRNA requires oligouridylation followed by decapping and simultaneous degradation of the mRNA both 5' to 3' and 3' to 5'. (PubMed id 18172165)1, 2 Mullen T.E. and Marzluff W.F. (2008)
- Human cell growth requires a functional cytoplasmic exosome, which is involved in various mRNA decay pathways. (PubMed id 17545563)1, 2 van Dijk E.L....Pruijn G.J. (2007)
- C1D and hMtr4p associate with the human exosome subunit PM/Scl-100 and are involved in pre-rRNA processing. (PubMed id 17412707)1, 2 Schilders G.... Pruijn G.J.M. (2007)
- Adenylation and exosome-mediated degradation of cotranscriptionally cleaved pre-messenger RNA in human cells. (PubMed id 16455498)1, 2 West S.... Proudfoot N.J. (2006)
- A protein interaction framework for human mRNA degradation. (PubMed id 15231747)1, 2 Lehner B. and Sanderson C.M. (2004)
|
External Searches for EXOSC10 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing EXOSC10 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing EXOSC10 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing EXOSC10 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for EXOSC10 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for EXOSC10 gene:
Search GeneIP for patents involving EXOSC10
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for EXOSC10 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | Browse OriGene shRNA RFPs | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for EXOSC10 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for EXOSC10 | | | OriGene Protein Over-expression Lysate for EXOSC10 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for EXOSC10 | | OriGene 3'-UTR Clone for EXOSC10 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for EXOSC10 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for EXOSC10 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for EXOSC10 | | OriGene Custom Protein Services for EXOSC10 | | | OriGene Custom Immunoassay Development | | |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat EXOSC10 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing EXOSC10 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat EXOSC10 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat EXOSC10 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat EXOSC10 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat EXOSC10 |
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| | | | Search Tocris compounds for EXOSC10 |
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 | | | EXOSC10 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for EXOSC10 |
|  |  |  | | | | Search ThermoFisher Antibodies for EXOSC10 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat EXOSC10 |
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