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Aliases for EXOSC10 Gene

Aliases for EXOSC10 Gene

  • Exosome Component 10 2 3
  • PMSCL2 3 4 6
  • P100 Polymyositis-Scleroderma Overlap Syndrome-Associated Autoantigen 3 4
  • Polymyositis/Scleroderma Autoantigen 100 KDa 3 4
  • Polymyositis/Scleroderma Autoantigen 2 3 4
  • PM/Scl-100 3 4
  • PMSCL 3 4
  • RRP6 3 4
  • Polymyositis/Scleroderma Autoantigen 2 (100kD) 2
  • Polymyositis/Scleroderma Autoantigen 2, 100kDa 2
  • Autoantigen PM/Scl 2 4
  • Autoantigen PM-SCL 3
  • EC 3.1.13.- 4
  • PM-Scl 3
  • Rrp6p 3
  • P4 3
  • P3 3
  • P2 3

External Ids for EXOSC10 Gene

Previous HGNC Symbols for EXOSC10 Gene

  • PMSCL2

Previous GeneCards Identifiers for EXOSC10 Gene

  • GC01M010837
  • GC01M011060
  • GC01M011049
  • GC01M010278

Summaries for EXOSC10 Gene

GeneCards Summary for EXOSC10 Gene

EXOSC10 (Exosome Component 10) is a Protein Coding gene. Diseases associated with EXOSC10 include polymyositis and scleroderma. Among its related pathways are Deadenylation-dependent mRNA decay and Purine metabolism (KEGG). GO annotations related to this gene include RNA binding and 3-5 exonuclease activity.

UniProtKB/Swiss-Prot for EXOSC10 Gene

  • Putative catalytic component of the RNA exosome complex which has 3->5 exoribonuclease activity and participates in a multitude of cellular RNA processing and degradation events. In the nucleus, the RNA exosome complex is involved in proper maturation of stable RNA species such as rRNA, snRNA and snoRNA, in the elimination of RNA processing by-products and non-coding pervasive transcripts, such as antisense RNA species and promoter-upstream transcripts (PROMPTs), and of mRNAs with processing defects, thereby limiting or excluding their export to the cytoplasm. The RNA exosome may be involved in Ig class switch recombination (CSR) and/or Ig variable region somatic hypermutation (SHM) by targeting AICDA deamination activity to transcribed dsDNA substrates. In the cytoplasm, the RNA exosome complex is involved in general mRNA turnover and specifically degrades inherently unstable mRNAs containing AU-rich elements (AREs) within their 3 untranslated regions, and in RNA surveillance pathways, preventing translation of aberrant mRNAs. It seems to be involved in degradation of histone mRNA. EXOSC10 has 3-5 exonuclease activity (By similarity). EXOSC10 is required for nucleolar localization of C1D and probably mediates the association of SKIV2L2, C1D and MPP6 wth the RNA exosome involved in the maturation of 5.8S rRNA.

Gene Wiki entry for EXOSC10 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for EXOSC10 Gene

Genomics for EXOSC10 Gene

Regulatory Elements for EXOSC10 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for EXOSC10 Gene

Start:
11,066,618 bp from pter
End:
11,099,904 bp from pter
Size:
33,287 bases
Orientation:
Minus strand

Genomic View for EXOSC10 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for EXOSC10 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for EXOSC10 Gene

Proteins for EXOSC10 Gene

  • Protein details for EXOSC10 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q01780-EXOSX_HUMAN
    Recommended name:
    Exosome component 10
    Protein Accession:
    Q01780
    Secondary Accessions:
    • B1AKQ0
    • B1AKQ1
    • Q15158

    Protein attributes for EXOSC10 Gene

    Size:
    885 amino acids
    Molecular mass:
    100831 Da
    Quaternary structure:
    • Component of the RNA exosome complex. The catalytically inactive RNA exosome core (Exo-9) complex is believed to associate with catalytic subunits EXOSC10, and DIS3 or DIS3L in cytoplasmic- and nuclear-specific RNA exosome complex forms. Interacts with C1D and MPHOSPH6. Interacts with ALYREF/THOC4.

    Three dimensional structures from OCA and Proteopedia for EXOSC10 Gene

    Alternative splice isoforms for EXOSC10 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for EXOSC10 Gene

Proteomics data for EXOSC10 Gene at MOPED

Post-translational modifications for EXOSC10 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for EXOSC10 Gene

Antibody Products

No data available for DME Specific Peptides for EXOSC10 Gene

Domains for EXOSC10 Gene

Protein Domains for EXOSC10 Gene

Suggested Antigen Peptide Sequences for EXOSC10 Gene

Graphical View of Domain Structure for InterPro Entry

Q01780

UniProtKB/Swiss-Prot:

EXOSX_HUMAN :
  • Q01780
Domain:
  • Contains 1 3-5 exonuclease domain.
  • Contains 1 HRDC domain.
genes like me logo Genes that share domains with EXOSC10: view

No data available for Gene Families for EXOSC10 Gene

Function for EXOSC10 Gene

Molecular function for EXOSC10 Gene

UniProtKB/Swiss-Prot Function: Putative catalytic component of the RNA exosome complex which has 3->5 exoribonuclease activity and participates in a multitude of cellular RNA processing and degradation events. In the nucleus, the RNA exosome complex is involved in proper maturation of stable RNA species such as rRNA, snRNA and snoRNA, in the elimination of RNA processing by-products and non-coding pervasive transcripts, such as antisense RNA species and promoter-upstream transcripts (PROMPTs), and of mRNAs with processing defects, thereby limiting or excluding their export to the cytoplasm. The RNA exosome may be involved in Ig class switch recombination (CSR) and/or Ig variable region somatic hypermutation (SHM) by targeting AICDA deamination activity to transcribed dsDNA substrates. In the cytoplasm, the RNA exosome complex is involved in general mRNA turnover and specifically degrades inherently unstable mRNAs containing AU-rich elements (AREs) within their 3 untranslated regions, and in RNA surveillance pathways, preventing translation of aberrant mRNAs. It seems to be involved in degradation of histone mRNA. EXOSC10 has 3-5 exonuclease activity (By similarity). EXOSC10 is required for nucleolar localization of C1D and probably mediates the association of SKIV2L2, C1D and MPP6 wth the RNA exosome involved in the maturation of 5.8S rRNA.

Enzyme Numbers (IUBMB) for EXOSC10 Gene

Gene Ontology (GO) - Molecular Function for EXOSC10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000166 nucleotide binding IEA --
GO:0003676 nucleic acid binding --
GO:0003824 catalytic activity --
GO:0004532 exoribonuclease activity IDA 17174896
GO:0005515 protein binding IPI 15231747
genes like me logo Genes that share ontologies with EXOSC10: view

Phenotypes for EXOSC10 Gene

MGI mutant phenotypes for EXOSC10:
inferred from 1 alleles
GenomeRNAi human phenotypes for EXOSC10:
genes like me logo Genes that share phenotypes with EXOSC10: view

Animal Model Products

CRISPR Products

miRNA for EXOSC10 Gene

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for EXOSC10

In Situ Assay Products

Flow Cytometry Products

No data available for Animal Models , Transcription Factor Targeting and HOMER Transcription for EXOSC10 Gene

Localization for EXOSC10 Gene

Subcellular locations from UniProtKB/Swiss-Prot for EXOSC10 Gene

Cytoplasm. Nucleus, nucleolus. Nucleus. Note=Strongly enriched in the nucleolus and a small amount has been found in cytoplasm supporting the existence of a nucleolar RNA exosome complex form.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for EXOSC10 Gene COMPARTMENTS Subcellular localization image for EXOSC10 gene
Compartment Confidence
nucleus 5
cytosol 3

Gene Ontology (GO) - Cellular Components for EXOSC10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000176 nuclear exosome (RNase complex) IEA --
GO:0000178 exosome (RNase complex) IDA 20531389
GO:0005622 intracellular --
GO:0005634 nucleus IDA --
GO:0005654 nucleoplasm IDA --
genes like me logo Genes that share ontologies with EXOSC10: view

Pathways for EXOSC10 Gene

genes like me logo Genes that share pathways with EXOSC10: view

Pathways by source for EXOSC10 Gene

1 KEGG pathway for EXOSC10 Gene
1 GeneGo (Thomson Reuters) pathway for EXOSC10 Gene

Gene Ontology (GO) - Biological Process for EXOSC10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000184 nuclear-transcribed mRNA catabolic process, nonsense-mediated decay IMP 22890540
GO:0000460 maturation of 5.8S rRNA IMP 17412707
GO:0000956 nuclear-transcribed mRNA catabolic process IMP 17545563
GO:0006139 nucleobase-containing compound metabolic process --
GO:0006396 RNA processing IEA --
genes like me logo Genes that share ontologies with EXOSC10: view

Transcripts for EXOSC10 Gene

Unigene Clusters for EXOSC10 Gene

Exosome component 10:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for EXOSC10

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for EXOSC10 Gene

No ASD Table

Relevant External Links for EXOSC10 Gene

GeneLoc Exon Structure for
EXOSC10
ECgene alternative splicing isoforms for
EXOSC10

Expression for EXOSC10 Gene

mRNA expression in normal human tissues for EXOSC10 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for EXOSC10 Gene

SOURCE GeneReport for Unigene cluster for EXOSC10 Gene Hs.632368

genes like me logo Genes that share expressions with EXOSC10: view

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for EXOSC10 Gene

Orthologs for EXOSC10 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for EXOSC10 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia EXOSC10 35
  • 99.4 (n)
  • 99.66 (a)
EXOSC10 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia EXOSC10 35
  • 87.03 (n)
  • 91.79 (a)
EXOSC10 36
  • 89 (a)
OneToOne
dog
(Canis familiaris)
Mammalia EXOSC10 35
  • 86.99 (n)
  • 89.82 (a)
EXOSC10 36
  • 87 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Exosc10 35
  • 83.13 (n)
  • 87.23 (a)
Exosc10 16
Exosc10 36
  • 87 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia EXOSC10 36
  • 78 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia EXOSC10 36
  • 73 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Exosc10 35
  • 83.45 (n)
  • 87.33 (a)
chicken
(Gallus gallus)
Aves EXOSC10 35
  • 72.71 (n)
  • 74.42 (a)
EXOSC10 36
  • 70 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 81 (a)
OneToMany
-- 36
  • 48 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia exosc10 35
  • 66.9 (n)
  • 67.61 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.12521 35
zebrafish
(Danio rerio)
Actinopterygii exosc10 35
  • 62.24 (n)
  • 62.87 (a)
exosc10 36
  • 59 (a)
OneToOne
zgc55695 35
fruit fly
(Drosophila melanogaster)
Insecta Rrp6 36
  • 32 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea crn-3 36
  • 29 (a)
OneToOne
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes RRP6 36
  • 30 (a)
OneToOne
RRP6 38
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 47 (a)
OneToOne
Species with no ortholog for EXOSC10:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for EXOSC10 Gene

ENSEMBL:
Gene Tree for EXOSC10 (if available)
TreeFam:
Gene Tree for EXOSC10 (if available)

Paralogs for EXOSC10 Gene

No data available for Paralogs for EXOSC10 Gene

Variants for EXOSC10 Gene

Sequence variations from dbSNP and Humsavar for EXOSC10 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs910660 -- 11,070,586(-) AAAAA(C/T)GTTGC intron-variant
rs910661 -- 11,070,059(-) GATAG(G/T)GGTCT intron-variant
rs1130683 -- 11,072,160(-) AACCG(C/T)TGGAA reference, synonymous-codon, nc-transcript-variant
rs1148482 -- 11,091,722(-) aagat(C/T)gcgcc intron-variant
rs1148483 -- 11,090,055(-) gcgtc(A/G)ctgca intron-variant

Structural Variations from Database of Genomic Variants (DGV) for EXOSC10 Gene

Variant ID Type Subtype PubMed ID
dgv137n71 CNV Loss 21882294
nsv870986 CNV Loss 21882294

Relevant External Links for EXOSC10 Gene

HapMap Linkage Disequilibrium report
EXOSC10

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for EXOSC10 Gene

Disorders for EXOSC10 Gene

MalaCards: The human disease database

MalaCards: The human disease database. (2) Diseases for EXOSC10 Gene including...

Search for EXOSC10 Gene in MalaCards »
genes like me logo Genes that share disorders with EXOSC10: view

No data available for UniProtKB/Swiss-Prot for EXOSC10 Gene

Publications for EXOSC10 Gene

  1. Cloning and characterization of the cDNA coding for a polymyositis- scleroderma overlap syndrome-related nucleolar 100-kD protein. (PMID: 1383382) Bluethner M. … Bautz F.A. (J. Exp. Med. 1992) 2 3 4
  2. Cloning of a complementary DNA coding for the 100-kD antigenic protein of the PM-Scl autoantigen. (PMID: 1644924) Ge Q. … Targoff I.N. (J. Clin. Invest. 1992) 2 3 4
  3. The yeast exosome and human PM-Scl are related complexes of 3'-->5' exonucleases. (PMID: 10465791) Allmang C. … Mitchell P. (Genes Dev. 1999) 3 4
  4. The human gene for mannan-binding lectin-associated serine protease-2 (MASP-2), the effector component of the lectin route of complement activation, is part of a tightly linked gene cluster on chromosome 1p36.2-3. (PMID: 11426320) Stover C. … Schwaeble W. (Genes Immun. 2001) 3 4
  5. Functional proteomic analysis of human nucleolus. (PMID: 12429849) Scherl A. … Diaz J.-J. (Mol. Biol. Cell 2002) 3 4

Products for EXOSC10 Gene

Sources for EXOSC10 Gene

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