Aliases for EXOSC1 Gene
Aliases for EXOSC1 Gene
External Ids for EXOSC1 Gene
- HGNC: 17286
- Entrez Gene: 51013
- Ensembl: ENSG00000171311
- OMIM: 606493
- UniProtKB: Q9Y3B2
Previous GeneCards Identifiers for EXOSC1 Gene
- GC10M098856
- GC10M099181
- GC10M092821
- GC10M099191
- GC10M099192
- GC10M099198
- GC10M099205
Summaries for EXOSC1 Gene
-
This gene encodes a core component of the exosome. The mammalian exosome is required for rapid degradation of AU rich element-containing RNAs but not for poly(A) shortening. The association of this protein with the exosome is mediated by protein-protein interactions with ribosomal RNA-processing protein 42 and ribosomal RNA-processing protein 46. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Jan 2016]
GeneCards Summary for EXOSC1 Gene
EXOSC1 (Exosome Component 1) is a Protein Coding gene. Diseases associated with EXOSC1 include Cerebellopontine Angle Tumor and Charcot-Marie-Tooth Disease, Demyelinating, Type 1C. Among its related pathways are CDK-mediated phosphorylation and removal of Cdc6 and Gene Expression. Gene Ontology (GO) annotations related to this gene include RNA binding and exoribonuclease activity.
UniProtKB/Swiss-Prot for EXOSC1 Gene
-
Non-catalytic component of the RNA exosome complex which has 3->5 exoribonuclease activity and participates in a multitude of cellular RNA processing and degradation events. In the nucleus, the RNA exosome complex is involved in proper maturation of stable RNA species such as rRNA, snRNA and snoRNA, in the elimination of RNA processing by-products and non-coding pervasive transcripts, such as antisense RNA species and promoter-upstream transcripts (PROMPTs), and of mRNAs with processing defects, thereby limiting or excluding their export to the cytoplasm. The RNA exosome may be involved in Ig class switch recombination (CSR) and/or Ig variable region somatic hypermutation (SHM) by targeting AICDA deamination activity to transcribed dsDNA substrates. In the cytoplasm, the RNA exosome complex is involved in general mRNA turnover and specifically degrades inherently unstable mRNAs containing AU-rich elements (AREs) within their 3 untranslated regions, and in RNA surveillance pathways, preventing translation of aberrant mRNAs. It seems to be involved in degradation of histone mRNA. The catalytic inactive RNA exosome core complex of 9 subunits (Exo-9) is proposed to play a pivotal role in the binding and presentation of RNA for ribonucleolysis, and to serve as a scaffold for the association with catalytic subunits and accessory proteins or complexes. EXOSC1 as peripheral part of the Exo-9 complex stabilizes the hexameric ring of RNase PH-domain subunits through contacts with EXOSC6 and EXOSC8.
Additional gene information for EXOSC1 Gene
No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for EXOSC1 Gene
Genomics for EXOSC1 Gene
GeneHancer (GH) Regulatory Elements for EXOSC1 Gene
Regulatory Element Products
Genomic Locations for EXOSC1 Gene
- chr10:97,435,909-97,446,017
- (GRCh38/hg38)
- Size:
- 10,109 bases
- Orientation:
- Minus strand
- chr10:99,195,666-99,205,774
- (GRCh37/hg19)
Genomic View for EXOSC1 Gene
- Cytogenetic band:
-
- 10q24.1 by Ensembl
- 10q24.1 by Entrez Gene
- 10q24.1 by HGNC


RefSeq DNA sequence for EXOSC1 Gene
Proteins for EXOSC1 Gene
-
Protein details for EXOSC1 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q9Y3B2-EXOS1_HUMAN
- Recommended name:
- Exosome complex component CSL4
- Protein Accession:
- Q9Y3B2
- B2R9B3
- Q5JTH3
Protein attributes for EXOSC1 Gene
- Size:
- 195 amino acids
- Molecular mass:
- 21452 Da
- Quaternary structure:
-
- Component of the RNA exosome complex. Specifically part of the catalytically inactive RNA exosome core (Exo-9) complex which is believed to associate with catalytic subunits EXOSC10, and DIS3 or DIS3L in cytoplasmic- and nuclear-specific RNA exosome complex forms. Exo-9 is formed by a hexameric ring of RNase PH domain-containing subunits specifically containing the heterodimers EXOSC4-EXOSC9, EXOSC5-EXOSC8 and EXOSC6-EXOSC7, and peripheral S1 domain-containing components EXOSC1, EXOSC2 and EXOSC3 located on the top of the ring structure. Interacts with EXOSC5, EXOSC7 and EXOSC10. Interacts with DDX60.
Protein Expression for EXOSC1 Gene
Post-translational modifications for EXOSC1 Gene
- Ubiquitination at posLast=9696 and Lys120
Other Protein References for EXOSC1 Gene
Antibody Products
- Novus Biologicals Antibodies for EXOSC1
-
Abcam antibodies for EXOSC1
- Invitrogen Antibodies for EXOSC1
- Search GeneTex for Antibodies for EXOSC1
Protein Products
-
OriGene Purified Proteins for EXOSC1
- Search Origene for MassSpec and Protein Over-expression Lysates for EXOSC1
- Origene Custom Protein Services for EXOSC1
- ProSpec Recombinant Proteins for EXOSC1
- Search GeneTex for Proteins for EXOSC1
-
Abcam proteins for EXOSC1
Assay Products
No data available for DME Specific Peptides for EXOSC1 Gene
Domains & Families for EXOSC1 Gene
Gene Families for EXOSC1 Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Plasma proteins
- Predicted intracellular proteins
Protein Domains for EXOSC1 Gene
- InterPro:
- Blocks:
- ProtoNet:
Suggested Antigen Peptide Sequences for EXOSC1 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
Q9Y3B2- Family:
-
- Belongs to the CSL4 family.
Function for EXOSC1 Gene
Molecular function for EXOSC1 Gene
- UniProtKB/Swiss-Prot Function:
- Non-catalytic component of the RNA exosome complex which has 3->5 exoribonuclease activity and participates in a multitude of cellular RNA processing and degradation events. In the nucleus, the RNA exosome complex is involved in proper maturation of stable RNA species such as rRNA, snRNA and snoRNA, in the elimination of RNA processing by-products and non-coding pervasive transcripts, such as antisense RNA species and promoter-upstream transcripts (PROMPTs), and of mRNAs with processing defects, thereby limiting or excluding their export to the cytoplasm. The RNA exosome may be involved in Ig class switch recombination (CSR) and/or Ig variable region somatic hypermutation (SHM) by targeting AICDA deamination activity to transcribed dsDNA substrates. In the cytoplasm, the RNA exosome complex is involved in general mRNA turnover and specifically degrades inherently unstable mRNAs containing AU-rich elements (AREs) within their 3 untranslated regions, and in RNA surveillance pathways, preventing translation of aberrant mRNAs. It seems to be involved in degradation of histone mRNA. The catalytic inactive RNA exosome core complex of 9 subunits (Exo-9) is proposed to play a pivotal role in the binding and presentation of RNA for ribonucleolysis, and to serve as a scaffold for the association with catalytic subunits and accessory proteins or complexes. EXOSC1 as peripheral part of the Exo-9 complex stabilizes the hexameric ring of RNase PH-domain subunits through contacts with EXOSC6 and EXOSC8.
Phenotypes From GWAS Catalog for EXOSC1 Gene
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0003723 | RNA binding | IEA,NAS | 11812149 |
GO:0004532 | NOT exoribonuclease activity | IDA | 17174896 |
GO:0005515 | protein binding | IPI | 11812149 |
Phenotypes for EXOSC1 Gene
- GenomeRNAi human phenotypes for EXOSC1:
-
- Increased viability
- Increased vaccinia virus (VACV) infection
- Increased gamma-H2AX phosphorylation
- Decreased viability
- shRNA abundance <= 50%
- Synthetic lethal with Ras
- Decreased viability in esophageal squamous lineage
- Resistant to vaccinia virus (VACV-A4L) infection
- Increased shRNA abundance (Z-score > 2)
- Decreased shRNA abundance (Z-score < -2)
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
- Cyagen custom Knockout/knockin (KOKI) mouse models for EXOSC1
-
-
ViGene Biosciences lentiviral particle packaged cDNA for EXOSC1 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for EXOSC1 gene
- Search ViGene Biosciences for EXOSC1
CRISPR Products
-
OriGene CRISPR knockouts for EXOSC1
- genomics-online: gRNA clones - Search results for 73 available EXOSC1 gene related products
- Overview of 73 available EXOSC1 gene related products
-
Recommended
- pPB-His-GST
- pGFP-C-shLenti
- pGFP-V-RS
- pRFP-C-RS
- pPB-C-His
- pPB-N-His
- pLenti-U6-sgRNA-SFFV-Cas9-2A-Puro
- pLenti-U6-sgRNA-PGK-Neo
- pCMV6-Entry
- pDONR223
- pLenti-C-mGFP
- pLenti-C-Myc-DDK
- pCMV6-XL4
- pCMV6-AC
- pPB-His-GST
- pGFP-C-shLenti
- pGFP-V-RS
- pRFP-C-RS
- pPB-C-His
- pPB-N-His
- pLenti-U6-sgRNA-SFFV-Cas9-2A-Puro
- pLenti-U6-sgRNA-PGK-Neo
- pCMV6-Entry
- pDONR223
- pLenti-C-mGFP
- pLenti-C-Myc-DDK
- pCMV6-XL4
- pCMV6-AC
- Applied Biological Materials CRISPR for EXOSC1
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for EXOSC1
- GenScript: Design CRISPR guide RNA sequences for EXOSC1
miRNA for EXOSC1 Gene
- miRTarBase miRNAs that target EXOSC1
miRNA Products
- Search ViGene Biosciences for EXOSC1
Inhibitory RNA Products
- Origene RNAi, sirna, and shrna products in human, mouse, rat for EXOSC1
- Browse OriGene Inhibitory RNA Products For EXOSC1
- genomics-online: shRNA clones - Search results for 73 available EXOSC1 gene related products
- Overview of 73 available EXOSC1 gene related products
-
Recommended
- pPB-His-GST
- pGFP-C-shLenti
- pGFP-V-RS
- pRFP-C-RS
- pPB-C-His
- pPB-N-His
- pLenti-U6-sgRNA-SFFV-Cas9-2A-Puro
- pLenti-U6-sgRNA-PGK-Neo
- pCMV6-Entry
- pDONR223
- pLenti-C-mGFP
- pLenti-C-Myc-DDK
- pCMV6-XL4
- pCMV6-AC
- pPB-His-GST
- pGFP-C-shLenti
- pGFP-V-RS
- pRFP-C-RS
- pPB-C-His
- pPB-N-His
- pLenti-U6-sgRNA-SFFV-Cas9-2A-Puro
- pLenti-U6-sgRNA-PGK-Neo
- pCMV6-Entry
- pDONR223
- pLenti-C-mGFP
- pLenti-C-Myc-DDK
- pCMV6-XL4
- pCMV6-AC
-
ViGene Biosciences ready-to-package AAV shRNAs for EXOSC1 gene
Clone Products
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- VectorBuilder custom plasmid, inducible vectors for EXOSC1
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for EXOSC1
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- genomics-online: cdna clones - Search results for 73 available EXOSC1 gene related products
- Overview of 73 available EXOSC1 gene related products
-
Recommended
- pPB-His-GST
- pGFP-C-shLenti
- pGFP-V-RS
- pRFP-C-RS
- pPB-C-His
- pPB-N-His
- pLenti-U6-sgRNA-SFFV-Cas9-2A-Puro
- pLenti-U6-sgRNA-PGK-Neo
- pCMV6-Entry
- pDONR223
- pLenti-C-mGFP
- pLenti-C-Myc-DDK
- pCMV6-XL4
- pCMV6-AC
- pPB-His-GST
- pGFP-C-shLenti
- pGFP-V-RS
- pRFP-C-RS
- pPB-C-His
- pPB-N-His
- pLenti-U6-sgRNA-SFFV-Cas9-2A-Puro
- pLenti-U6-sgRNA-PGK-Neo
- pCMV6-Entry
- pDONR223
- pLenti-C-mGFP
- pLenti-C-Myc-DDK
- pCMV6-XL4
- pCMV6-AC
- orf clones - Search results for 73 available EXOSC1 gene related products
- Overview of 73 available EXOSC1 gene related products
-
Recommended
- pPB-His-GST
- pGFP-C-shLenti
- pGFP-V-RS
- pRFP-C-RS
- pPB-C-His
- pPB-N-His
- pLenti-U6-sgRNA-SFFV-Cas9-2A-Puro
- pLenti-U6-sgRNA-PGK-Neo
- pCMV6-Entry
- pDONR223
- pLenti-C-mGFP
- pLenti-C-Myc-DDK
- pCMV6-XL4
- pCMV6-AC
- pPB-His-GST
- pGFP-C-shLenti
- pGFP-V-RS
- pRFP-C-RS
- pPB-C-His
- pPB-N-His
- pLenti-U6-sgRNA-SFFV-Cas9-2A-Puro
- pLenti-U6-sgRNA-PGK-Neo
- pCMV6-Entry
- pDONR223
- pLenti-C-mGFP
- pLenti-C-Myc-DDK
- pCMV6-XL4
- pCMV6-AC
- Applied Biological Materials Clones for EXOSC1
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Cell Line Products
-
ViGene Biosciences adenoviral particle packaged cDNA for EXOSC1 gene
-
ViGene Biosciences lentiviral particle packaged cDNA for EXOSC1 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for EXOSC1 gene
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for EXOSC1 Gene
Localization for EXOSC1 Gene
Subcellular locations from UniProtKB/Swiss-Prot for EXOSC1 Gene
- Nucleus, nucleolus. Nucleus. Cytoplasm.
- Nuclear bodies (2)
- Nucleoplasm (2)
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0000176 | nuclear exosome (RNase complex) | IBA | -- |
GO:0000178 | exosome (RNase complex) | NAS,IEA | 11812149 |
GO:0005634 | nucleus | IEA | -- |
GO:0005654 | nucleoplasm | TAS | -- |
GO:0005730 | nucleolus | IDA,IEA | 11812149 |
Pathways & Interactions for EXOSC1 Gene
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | CDK-mediated phosphorylation and removal of Cdc6 | ||
2 | Deadenylation-dependent mRNA decay |
.46
|
|
3 | rRNA processing in the nucleus and cytosol |
.89
|
|
4 | PERK regulates gene expression | ||
5 | Gene Expression |
.48
|
Pathways by source for EXOSC1 Gene
14 Reactome pathways for EXOSC1 Gene
1 KEGG pathway for EXOSC1 Gene
1 GeneGo (Thomson Reuters) pathway for EXOSC1 Gene
Interacting Proteins for EXOSC1 Gene
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0006364 | rRNA processing | TAS | -- |
GO:0043488 | regulation of mRNA stability | TAS | -- |
GO:0043928 | exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay | TAS | -- |
No data available for SIGNOR curated interactions for EXOSC1 Gene
Transcripts for EXOSC1 Gene
mRNA/cDNA for EXOSC1 Gene
- (8) REFSEQ mRNAs :
- (3) Additional mRNA sequences :
- (183) Selected AceView cDNA sequences:
- (11) Ensembl transcripts including schematic representations, and UCSC links where relevant :
CRISPR Products
-
OriGene CRISPR knockouts for EXOSC1
- genomics-online: gRNA clones - Search results for 73 available EXOSC1 gene related products
- Overview of 73 available EXOSC1 gene related products
-
Recommended
- pPB-His-GST
- pGFP-C-shLenti
- pGFP-V-RS
- pRFP-C-RS
- pPB-C-His
- pPB-N-His
- pLenti-U6-sgRNA-SFFV-Cas9-2A-Puro
- pLenti-U6-sgRNA-PGK-Neo
- pCMV6-Entry
- pDONR223
- pLenti-C-mGFP
- pLenti-C-Myc-DDK
- pCMV6-XL4
- pCMV6-AC
- pPB-His-GST
- pGFP-C-shLenti
- pGFP-V-RS
- pRFP-C-RS
- pPB-C-His
- pPB-N-His
- pLenti-U6-sgRNA-SFFV-Cas9-2A-Puro
- pLenti-U6-sgRNA-PGK-Neo
- pCMV6-Entry
- pDONR223
- pLenti-C-mGFP
- pLenti-C-Myc-DDK
- pCMV6-XL4
- pCMV6-AC
- Applied Biological Materials CRISPR for EXOSC1
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for EXOSC1
- GenScript: Design CRISPR guide RNA sequences for EXOSC1
miRNA Products
- Search ViGene Biosciences for EXOSC1
Inhibitory RNA Products
- Origene RNAi, sirna, and shrna products in human, mouse, rat for EXOSC1
- Browse OriGene Inhibitory RNA Products For EXOSC1
- genomics-online: shRNA clones - Search results for 73 available EXOSC1 gene related products
- Overview of 73 available EXOSC1 gene related products
-
Recommended
- pPB-His-GST
- pGFP-C-shLenti
- pGFP-V-RS
- pRFP-C-RS
- pPB-C-His
- pPB-N-His
- pLenti-U6-sgRNA-SFFV-Cas9-2A-Puro
- pLenti-U6-sgRNA-PGK-Neo
- pCMV6-Entry
- pDONR223
- pLenti-C-mGFP
- pLenti-C-Myc-DDK
- pCMV6-XL4
- pCMV6-AC
- pPB-His-GST
- pGFP-C-shLenti
- pGFP-V-RS
- pRFP-C-RS
- pPB-C-His
- pPB-N-His
- pLenti-U6-sgRNA-SFFV-Cas9-2A-Puro
- pLenti-U6-sgRNA-PGK-Neo
- pCMV6-Entry
- pDONR223
- pLenti-C-mGFP
- pLenti-C-Myc-DDK
- pCMV6-XL4
- pCMV6-AC
-
ViGene Biosciences ready-to-package AAV shRNAs for EXOSC1 gene
Clone Products
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- VectorBuilder custom plasmid, inducible vectors for EXOSC1
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for EXOSC1
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- genomics-online: cdna clones - Search results for 73 available EXOSC1 gene related products
- Overview of 73 available EXOSC1 gene related products
-
Recommended
- pPB-His-GST
- pGFP-C-shLenti
- pGFP-V-RS
- pRFP-C-RS
- pPB-C-His
- pPB-N-His
- pLenti-U6-sgRNA-SFFV-Cas9-2A-Puro
- pLenti-U6-sgRNA-PGK-Neo
- pCMV6-Entry
- pDONR223
- pLenti-C-mGFP
- pLenti-C-Myc-DDK
- pCMV6-XL4
- pCMV6-AC
- pPB-His-GST
- pGFP-C-shLenti
- pGFP-V-RS
- pRFP-C-RS
- pPB-C-His
- pPB-N-His
- pLenti-U6-sgRNA-SFFV-Cas9-2A-Puro
- pLenti-U6-sgRNA-PGK-Neo
- pCMV6-Entry
- pDONR223
- pLenti-C-mGFP
- pLenti-C-Myc-DDK
- pCMV6-XL4
- pCMV6-AC
- orf clones - Search results for 73 available EXOSC1 gene related products
- Overview of 73 available EXOSC1 gene related products
-
Recommended
- pPB-His-GST
- pGFP-C-shLenti
- pGFP-V-RS
- pRFP-C-RS
- pPB-C-His
- pPB-N-His
- pLenti-U6-sgRNA-SFFV-Cas9-2A-Puro
- pLenti-U6-sgRNA-PGK-Neo
- pCMV6-Entry
- pDONR223
- pLenti-C-mGFP
- pLenti-C-Myc-DDK
- pCMV6-XL4
- pCMV6-AC
- pPB-His-GST
- pGFP-C-shLenti
- pGFP-V-RS
- pRFP-C-RS
- pPB-C-His
- pPB-N-His
- pLenti-U6-sgRNA-SFFV-Cas9-2A-Puro
- pLenti-U6-sgRNA-PGK-Neo
- pCMV6-Entry
- pDONR223
- pLenti-C-mGFP
- pLenti-C-Myc-DDK
- pCMV6-XL4
- pCMV6-AC
- Applied Biological Materials Clones for EXOSC1
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
ExUns: | 1 | ^ | 2a | · | 2b | ^ | 3 | ^ | 4 | ^ | 5a | · | 5b | ^ | 6a | · | 6b | ^ | 7a | · | 7b | ^ | 8a | · | 8b | ^ | 9a | · | 9b | · | 9c |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
SP1: | - | - | - | - | |||||||||||||||||||||||||||
SP2: | - | - | - | - | - | ||||||||||||||||||||||||||
SP3: | - | ||||||||||||||||||||||||||||||
SP4: | - | - | |||||||||||||||||||||||||||||
SP5: | - | - | |||||||||||||||||||||||||||||
SP6: | |||||||||||||||||||||||||||||||
SP7: | - |
Expression for EXOSC1 Gene
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for EXOSC1 Gene
NURSA nuclear receptor signaling pathways regulating expression of EXOSC1 Gene:
EXOSC1SOURCE GeneReport for Unigene cluster for EXOSC1 Gene:
Hs.632089Evidence on tissue expression from TISSUES for EXOSC1 Gene
- Nervous system(4.5)
Primer Products
-
OriGene qPCR primer pairs for EXOSC1
-
OriGene qPCR primer pairs and template standards for EXOSC1
- genomics-online: primer clones - Search results for 73 available EXOSC1 gene related products
- Overview of 73 available EXOSC1 gene related products
-
Recommended
- pPB-His-GST
- pGFP-C-shLenti
- pGFP-V-RS
- pRFP-C-RS
- pPB-C-His
- pPB-N-His
- pLenti-U6-sgRNA-SFFV-Cas9-2A-Puro
- pLenti-U6-sgRNA-PGK-Neo
- pCMV6-Entry
- pDONR223
- pLenti-C-mGFP
- pLenti-C-Myc-DDK
- pCMV6-XL4
- pCMV6-AC
- pPB-His-GST
- pGFP-C-shLenti
- pGFP-V-RS
- pRFP-C-RS
- pPB-C-His
- pPB-N-His
- pLenti-U6-sgRNA-SFFV-Cas9-2A-Puro
- pLenti-U6-sgRNA-PGK-Neo
- pCMV6-Entry
- pDONR223
- pLenti-C-mGFP
- pLenti-C-Myc-DDK
- pCMV6-XL4
- pCMV6-AC
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for EXOSC1 Gene
Orthologs for EXOSC1 Gene
This gene was present in the common ancestor of eukaryotes.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
chimpanzee (Pan troglodytes) |
Mammalia | EXOSC1 33 34 |
|
||
oppossum (Monodelphis domestica) |
Mammalia | EXOSC1 34 |
|
OneToOne | |
cow (Bos Taurus) |
Mammalia | EXOSC1 33 34 |
|
||
dog (Canis familiaris) |
Mammalia | EXOSC1 33 34 |
|
||
platypus (Ornithorhynchus anatinus) |
Mammalia | EXOSC1 34 |
|
OneToOne | |
mouse (Mus musculus) |
Mammalia | Exosc1 33 16 34 |
|
||
rat (Rattus norvegicus) |
Mammalia | Exosc1 33 |
|
||
chicken (Gallus gallus) |
Aves | EXOSC1 34 |
|
OneToOne | |
lizard (Anolis carolinensis) |
Reptilia | EXOSC1 34 |
|
OneToOne | |
tropical clawed frog (Silurana tropicalis) |
Amphibia | exosc1 33 |
|
||
Str.6115 33 |
|
||||
zebrafish (Danio rerio) |
Actinopterygii | exosc1 33 34 |
|
||
rainbow trout (Oncorhynchus mykiss) |
Actinopterygii | Omy.1793 33 |
|
||
African malaria mosquito (Anopheles gambiae) |
Insecta | AgaP_AGAP008063 33 |
|
||
fruit fly (Drosophila melanogaster) |
Insecta | Csl4 33 34 |
|
||
worm (Caenorhabditis elegans) |
Secernentea | exos-1 33 34 |
|
||
baker's yeast (Saccharomyces cerevisiae) |
Saccharomycetes | CSL4 33 34 36 |
|
||
A. gosspyii yeast (Ashbya gossypii) |
Saccharomycetes | AGOS_ABL199W 33 |
|
||
K. lactis yeast (Kluyveromyces lactis) |
Saccharomycetes | KLLA0D19701g 33 |
|
||
thale cress (Arabidopsis thaliana) |
eudicotyledons | AT5G38890 33 |
|
||
rice (Oryza sativa) |
Liliopsida | Os02g0815800 33 |
|
||
sea squirt (Ciona savignyi) |
Ascidiacea | -- 34 |
|
OneToOne | |
bread mold (Neurospora crassa) |
Ascomycetes | NCU04155 33 |
|
||
fission yeast (Schizosaccharomyces pombe) |
Schizosaccharomycetes | csl4 33 |
|
||
sea squirt (Ciona intestinalis) |
Ascidiacea | Cin.2962 33 |
|
- Species where no ortholog for EXOSC1 was found in the sources mined by GeneCards:
-
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
Paralogs for EXOSC1 Gene
No data available for Paralogs for EXOSC1 Gene
Variants for EXOSC1 Gene
SNP ID | Clin | Chr 10 pos | Variation | AA Info | Type |
---|---|---|---|---|---|
rs1000058773 | -- | 97,446,901(-) | T/A | upstream_transcript_variant | |
rs1000433704 | -- | 97,438,159(-) | C/A/T | intron_variant | |
rs1000519724 | -- | 97,443,213(-) | G/A | intron_variant | |
rs1000572108 | -- | 97,443,546(-) | G/A | intron_variant | |
rs1000675822 | -- | 97,437,415(-) | A/G | intron_variant |
Variant ID | Type | Subtype | PubMed ID |
---|---|---|---|
esv3624313 | CNV | gain | 21293372 |
nsv1110852 | OTHER | inversion | 24896259 |
nsv467440 | CNV | loss | 19166990 |
nsv552025 | CNV | loss | 21841781 |
Additional Variant Information for EXOSC1 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- EXOSC1
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for EXOSC1 Gene
Disorders for EXOSC1 Gene
Disorder | Aliases | PubMed IDs |
---|---|---|
cerebellopontine angle tumor |
|
|
charcot-marie-tooth disease, demyelinating, type 1c |
|
|
Additional Disease Information for EXOSC1
No data available for UniProtKB/Swiss-Prot and Genatlas for EXOSC1 Gene
Publications for EXOSC1 Gene
- Protein-protein interactions of hCsl4p with other human exosome subunits. (PMID: 11812149) Raijmakers R … Pruijn GJ (Journal of molecular biology 2002) 2 3 4 22 58
- AU binding proteins recruit the exosome to degrade ARE-containing mRNAs. (PMID: 11719186) Chen CY … Karin M (Cell 2001) 2 3 4 58
- DDX60, a DEXD/H box helicase, is a novel antiviral factor promoting RIG-I-like receptor-mediated signaling. (PMID: 21791617) Miyashita M … Seya T (Molecular and cellular biology 2011) 3 4 58
- Dis3-like 1: a novel exoribonuclease associated with the human exosome. (PMID: 20531389) Staals RH … Pruijn GJ (The EMBO journal 2010) 3 4 58
- Reconstitution, activities, and structure of the eukaryotic RNA exosome. (PMID: 17174896) Liu Q … Lima CD (Cell 2006) 3 4 58
Products for EXOSC1 Gene
- Browse R&D Systems for Antibodies
- Browse R&D Systems for Human Recombinant Proteins
- Browse R&D Systems for biochemical assays
- Browse Primary Antibodies
- Browse Proteins and Enzymes
- Browse ELISAs
- Browse Activity Assays
- Browse cDNA Clones
- Browse Cell Culture Products
- Browse Cell Selection and Detection Kits
- Browse DNA Damage and Repair Kits
- Browse ELISpot/FluoroSpot Kits and Development Modules
- Browse Flow Cytometry Kits
- Browse Immunoprecipitation Assays
- Browse Luminex Assays
- Browse Peptides
- Browse Proteome Profiler Antibody Arrays
- Browse Small Molecules
- Custom Antibody ServicesOriGene Antibodies for EXOSC1
- Browse OriGene ELISA Kits
- Custom Assay Services
- OriGene Purified Proteins for EXOSC1
- Search Origene for MassSpec and Protein Over-expression Lysates for EXOSC1
- Origene Custom Protein Services for EXOSC1
- Origene shrna, sirna, and RNAi products in human, mouse, rat for EXOSC1
- Browse OriGene Inhibitory RNA Products For EXOSC1
- OriGene qPCR primer pairs and template standards for EXOSC1
- OriGene qPCR primer pairs for EXOSC1
- OriGene CRISPR knockouts for EXOSC1
- OriGene ORF clones in human for EXOSC1
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Browse OriGene miRNA Products For EXOSC1
- GenScript: Next-day shipping of latest version cDNA ORF clones for EXOSC1 in any vector
- GenScript Custom Purified and Recombinant Proteins Services for EXOSC1
- GenScript Custom Assay Services for EXOSC1
- GenScript Custom overexpressing Cell Line Services for EXOSC1
- GenScript: Design CRISPR guide RNA sequences for EXOSC1
- Design optimal peptide antigens
- CloneReady with Over 120,000 Genes
- Gene Synthesis: Any Gene in Any Vector
- Vector-based siRNA and miRNA, Ready for Transfection
- Gene Mutant Library, Variants up to 10^11
- Plasmid Preparation
- GenScript Custom Peptide Services for EXOSC1
- Browse Sino Biological cDNA Clones
- Browse Sino Biological Cell Lysates
- Browse Sino Biological Recombinant Proteins
- Browse Sino Biological Antibodies
- Browse Sino Biological Assays
- Browse Sino Biological ELISA Kits
- Browse Sino Biological ELISA Pair Sets
- Browse Sino Biological CRO Services
- Browse Sino Biological Control Vectors
- Sino Biological Transfection Reagent
- Sino Biological Anti-His Tag Antibody
- Novus Biologicals Antibodies for EXOSC1
- Novus Biologicals lysates and proteins for EXOSC1
- Novus Biologicals
- Novus Biologicals Tissue Microarrays
- Abcam antibodies for EXOSC1
- Abcam proteins for EXOSC1
- Find your target
- Browse Primary Antibodies
- Browse Conjugated Primary Antibodies
- Browse Secondary Antibodies
- Browse ELISA Kits
- Browse Matched Antibody Pairs
- Browse Proteins and Peptides
- Search Knockout (KO) Validated Antibodies
- Browse Monoclonal Antibodies
- Browse Recombinant Antibodies
- ProSpec Recombinant Proteins for EXOSC1
- Browse Antibodies at Cloud-Clone Corp.
- Browse Proteins at Cloud-Clone Corp.
- Browse Assay Kits at Cloud-Clone Corp.
- Browse Knockouts at Cloud-Clone Corp.
- Browse Knockins at Cloud-Clone Corp.
- Cloud-Clone Corp. disease models service
- Browse cDNA clones at Cloud-Clone Corp.
- Browse primers at Cloud-Clone Corp.
- Cloud-Clone Corp. primary cells service
- Invitrogen Antibodies for EXOSC1
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- Cyagen custom Knockout/knockin (KOKI) mouse models for EXOSC1
- VectorBuilder custom plasmid, inducible vectors for EXOSC1
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for EXOSC1
- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- antibodies-online: Search results for 4 available H3F3AP4 Antibodies ranked by validation data
- Compare Top H3F3AP4 Antibodies
- Quality Products:
- antibodies-online: Search results for available H3F3AP4 related products ranked by validation data
- antibodies-online: Search results for 7 available H3F3AP4 Proteins ranked by validation data
- Compare Top H3F3AP4 Proteins
- Search GeneTex for Antibodies for EXOSC1
- Search GeneTex for Proteins for EXOSC1
- ViGene Biosciences adenoviral particle packaged cDNA for EXOSC1 gene
- ViGene Biosciences lentiviral particle packaged cDNA for EXOSC1 gene
- ViGene Biosciences ready-to-package AAV shRNAs for EXOSC1 gene
- Search ViGene Biosciences for EXOSC1
- genomics-online: cdna clones - Search results for 73 available H3F3AP4 gene related products
- Overview of 73 available H3F3AP4 gene related products
- Recommended
- pCMV6-AC
- pCMV6-XL4
- pLenti-C-Myc-DDK
- pLenti-C-mGFP
- pDONR223
- pCMV6-Entry
- pLenti-U6-sgRNA-PGK-Neo
- pLenti-U6-sgRNA-SFFV-Cas9-2A-Puro
- pPB-N-His
- pPB-C-His
- pRFP-C-RS
- pGFP-V-RS
- pGFP-C-shLenti
- pPB-His-GST
- pCMV6-AC
- pCMV6-XL4
- pLenti-C-Myc-DDK
- pLenti-C-mGFP
- pDONR223
- pCMV6-Entry
- pLenti-U6-sgRNA-PGK-Neo
- pLenti-U6-sgRNA-SFFV-Cas9-2A-Puro
- pPB-N-His
- pPB-C-His
- pRFP-C-RS
- pGFP-V-RS
- pGFP-C-shLenti
- pPB-His-GST
- orf clones - Search results for 73 available H3F3AP4 gene related products
- Overview of 73 available H3F3AP4 gene related products
- Recommended
- pCMV6-AC
- pCMV6-XL4
- pLenti-C-Myc-DDK
- pLenti-C-mGFP
- pDONR223
- pCMV6-Entry
- pLenti-U6-sgRNA-PGK-Neo
- pLenti-U6-sgRNA-SFFV-Cas9-2A-Puro
- pPB-N-His
- pPB-C-His
- pRFP-C-RS
- pGFP-V-RS
- pGFP-C-shLenti
- pPB-His-GST
- pCMV6-AC
- pCMV6-XL4
- pLenti-C-Myc-DDK
- pLenti-C-mGFP
- pDONR223
- pCMV6-Entry
- pLenti-U6-sgRNA-PGK-Neo
- pLenti-U6-sgRNA-SFFV-Cas9-2A-Puro
- pPB-N-His
- pPB-C-His
- pRFP-C-RS
- pGFP-V-RS
- pGFP-C-shLenti
- pPB-His-GST
- genomics-online: gRNA clones - Search results for 73 available H3F3AP4 gene related products
- Overview of 73 available H3F3AP4 gene related products
- Recommended
- pCMV6-AC
- pCMV6-XL4
- pLenti-C-Myc-DDK
- pLenti-C-mGFP
- pDONR223
- pCMV6-Entry
- pLenti-U6-sgRNA-PGK-Neo
- pLenti-U6-sgRNA-SFFV-Cas9-2A-Puro
- pPB-N-His
- pPB-C-His
- pRFP-C-RS
- pGFP-V-RS
- pGFP-C-shLenti
- pPB-His-GST
- pCMV6-AC
- pCMV6-XL4
- pLenti-C-Myc-DDK
- pLenti-C-mGFP
- pDONR223
- pCMV6-Entry
- pLenti-U6-sgRNA-PGK-Neo
- pLenti-U6-sgRNA-SFFV-Cas9-2A-Puro
- pPB-N-His
- pPB-C-His
- pRFP-C-RS
- pGFP-V-RS
- pGFP-C-shLenti
- pPB-His-GST
- genomics-online: primer clones - Search results for 73 available H3F3AP4 gene related products
- Overview of 73 available H3F3AP4 gene related products
- Recommended
- pCMV6-AC
- pCMV6-XL4
- pLenti-C-Myc-DDK
- pLenti-C-mGFP
- pDONR223
- pCMV6-Entry
- pLenti-U6-sgRNA-PGK-Neo
- pLenti-U6-sgRNA-SFFV-Cas9-2A-Puro
- pPB-N-His
- pPB-C-His
- pRFP-C-RS
- pGFP-V-RS
- pGFP-C-shLenti
- pPB-His-GST
- pCMV6-AC
- pCMV6-XL4
- pLenti-C-Myc-DDK
- pLenti-C-mGFP
- pDONR223
- pCMV6-Entry
- pLenti-U6-sgRNA-PGK-Neo
- pLenti-U6-sgRNA-SFFV-Cas9-2A-Puro
- pPB-N-His
- pPB-C-His
- pRFP-C-RS
- pGFP-V-RS
- pGFP-C-shLenti
- pPB-His-GST
- genomics-online: shRNA clones - Search results for 73 available H3F3AP4 gene related products
- Overview of 73 available H3F3AP4 gene related products
- Recommended
- pCMV6-AC
- pCMV6-XL4
- pLenti-C-Myc-DDK
- pLenti-C-mGFP
- pDONR223
- pCMV6-Entry
- pLenti-U6-sgRNA-PGK-Neo
- pLenti-U6-sgRNA-SFFV-Cas9-2A-Puro
- pPB-N-His
- pPB-C-His
- pRFP-C-RS
- pGFP-V-RS
- pGFP-C-shLenti
- pPB-His-GST
- pCMV6-AC
- pCMV6-XL4
- pLenti-C-Myc-DDK
- pLenti-C-mGFP
- pDONR223
- pCMV6-Entry
- pLenti-U6-sgRNA-PGK-Neo
- pLenti-U6-sgRNA-SFFV-Cas9-2A-Puro
- pPB-N-His
- pPB-C-His
- pRFP-C-RS
- pGFP-V-RS
- pGFP-C-shLenti
- pPB-His-GST
Sources for EXOSC1 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) ASD
- (29) ECgene
- (30) GeneAnnot
- (31) CGAP SAGE
- (32) SOURCE
- (33) HomoloGene
- (34) PanEnsembl
- (35) euGenes
- (36) SGD
- (37) FlyBase
- (38) WormBase
- (39) Pseudogene
- (40) DGV
- (41) dbSNP
- (42) GenAtlas
- (43) HGMD
- (44) GAD
- (45) BGMUT
- (46) HuGE
- (47) Atlas
- (48) Cell Signaling Technology
- (49) GenBank
- (50) H-invDB
- (51) HORDE
- (52) HUGE
- (53) IMGT
- (54) Leiden
- (55) miRBase
- (56) DME
- (57) OriGene
- (58) PubMed
- (59) R&D Systems
- (60) TGDB
- (61) Tocris
- (62) Abcam
- (63) Novus Biologicals
- (64) ProSpec
- (65) Sino Biological
- (66) GenScript
- (67) Qiagen
- (68) Cloud-Clone Corp.
- (69) OCA
- (70) Proteopedia
- (71) MOPED
- (72) neXtProt
- (73) Reactome
- (74) GeneGo (Thomson Reuters)
- (75) fRNAdb
- (76) DISEASES
- (77) SIMAP
- (78) GenomeRNAi
- (79) LifeMap
- (80) miRTarBase
- (81) MalaCards
- (82) Invitrogen
- (83) BitterDB
- (84) Vector BioLabs
- (85) ESI-BIO
- (86) RefSeq
- (87) BioSystems
- (88) MaxQB
- (89) IUPHAR
- (90) BioGPS
- (91) Illumina
- (92) COMPARTMENTS
- (93) HOMER
- (94) PaxDb
- (95) ApexBio
- (96) Addgene
- (97) antibodies-online
- (98) CYP
- (99) NONCODE
- (100) SwitchGear Genomics
- (101) TreeFam
- (102) PathCards
- (103) GeneReviews
- (104) GeneTex
- (105) Taconic Biosciences
- (106) GTEx
- (107) ProteomicsDB
- (108) SCBT
- (109) DGIdb
- (110) ClinicalTrials
- (111) FDA Approved Drugs
- (112) RVIS
- (113) SIGNOR
- (114) diseasecard
- (115) NIH Rare Diseases
- (116) Orphanet
- (117) UMLS
- (118) GTR
- (119) Disease Ontology
- (120) Genetics Home Reference
- (121) MeSH
- (122) MedlinePlus
- (123) CDC
- (124) NINDS
- (125) NCBI Bookshelf
- (126) ClinVar
- (127) Gene Damage Index
- (128) ViGene Biosciences
- (129) HPO
- (130) UDN
- (131) VISTA
- (132) FANTOM5
- (133) ENCODE
- (134) ProSci
- (135) Horizon
- (136) NURSA
- (137) IID
- (138) Cyagen
- (139) VectorBuilder
- (140) SNPedia
- (141) BRCA Exchange
- (142) St John's Lab
- (143) CIViC
- (144) ProteoGenix
- (145) dbSUPER
- (146) TISSUES
- (147) Gene ORGANizer
- (148) abm
- (149) CrownBio
- (150) Human Protein Atlas
- (151) GWAS Catalog
- (152) Monarch Initiative
- (153) DataMed
- (154) HumanCyc
- (155) genomics-online
- (156) UCNEbase
- (157) EPDnew