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Aliases for EXOG Gene

Aliases for EXOG Gene

  • Exo/Endonuclease G 2 3 5
  • Endonuclease G-Like 1 2 3 4
  • Endo/Exonuclease (5-3), Endonuclease G-Like 2 3
  • Endonuclease G-Like 2 2 3
  • Endo G-Like 1 3 4
  • ENDOGL1 3 4
  • ENDOGL2 3 4
  • ENGL 3 4
  • Nuclease EXOG, Mitochondrial 3
  • EC 3.1.30.- 4
  • EC 3.1.30 61
  • ENGL-A 3
  • ENGL-B 3
  • ENGLA 3
  • ENGLB 3

External Ids for EXOG Gene

Previous HGNC Symbols for EXOG Gene

  • ENDOGL1
  • ENDOGL2

Previous GeneCards Identifiers for EXOG Gene

  • GC03P038513
  • GC03P038537

Summaries for EXOG Gene

Entrez Gene Summary for EXOG Gene

  • This gene encodes an endo/exonuclease with 5'-3' exonuclease activity. The encoded enzyme catalyzes the hydrolysis of ester linkages at the 5' end of a nucleic acid chain. This enzyme is localized to the mitochondria and may play a role in programmed cell death. Alternatively spliced transcript variants have been described. A pseudogene exists on chromosome 18. [provided by RefSeq, Feb 2009]

GeneCards Summary for EXOG Gene

EXOG (Exo/Endonuclease G) is a Protein Coding gene. GO annotations related to this gene include nucleic acid binding and endonuclease activity. An important paralog of this gene is ENDOG.

UniProtKB/Swiss-Prot for EXOG Gene

  • Endo/exonuclease with nicking activity towards supercoiled DNA, a preference for single-stranded DNA and 5-3 exonuclease activity.

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for EXOG Gene

Genomics for EXOG Gene

Regulatory Elements for EXOG Gene

Enhancers for EXOG Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH03G038457 1 Ensembl ENCODE 25.6 -36.4 -36439 4.3 ETV1 ZNF133 MAX ZIC2 ZFHX2 SCRT2 EGR2 STAT1 ATF2 GABPA EXOG RNU6-1227P ACVR2B-AS1 GC03P038491
GH03G038495 1.1 ENCODE 16.3 +0.2 230 1.9 PKNOX1 AGO1 WRNIP1 ARID4B SIN3A DMAP1 ZNF2 YY1 CBX5 ZNF143 EXOG GORASP1 SNORA62 OXSR1 GC03M038505 ENSG00000207512
GH03G038531 1.1 VISTA dbSUPER 16 +36.8 36842 3.1 RFX1 NFIB CEBPB CEBPG ZIC2 ZNF507 NFIC ZNF316 GATA2 KLF9 EXOG PIR44042 PIR46951
GH03G038452 1.1 ENCODE 13.7 -41.4 -41354 4.0 HDGF PKNOX1 CREB3L1 AGO1 ARID4B SIN3A DMAP1 FEZF1 ZNF2 YY1 SNORA62 GORASP1 OXSR1 EXOG ACVR2B-AS1 ACVR2B
GH03G038516 0.7 dbSUPER 17.6 +21.1 21051 1.7 CTCF PKNOX1 BACH1 CEBPG CHAMP1 FOSL1 FOXM1 ZNF316 NFE2 MAFK EXOG RNU6-1227P DDTP1 PIR53114
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around EXOG on UCSC Golden Path with GeneCards custom track

Promoters for EXOG Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000151010 573 1001 PKNOX1 AGO1 WRNIP1 ARID4B SIN3A DMAP1 ZNF2 YY1 CBX5 ZNF143

Genomic Location for EXOG Gene

Chromosome:
3
Start:
38,496,127 bp from pter
End:
38,542,161 bp from pter
Size:
46,035 bases
Orientation:
Plus strand

Genomic View for EXOG Gene

Genes around EXOG on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
EXOG Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for EXOG Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for EXOG Gene

Proteins for EXOG Gene

  • Protein details for EXOG Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9Y2C4-EXOG_HUMAN
    Recommended name:
    Nuclease EXOG, mitochondrial
    Protein Accession:
    Q9Y2C4
    Secondary Accessions:
    • A8K242
    • B4DVG2
    • Q3SXM9
    • Q9Y2C8

    Protein attributes for EXOG Gene

    Size:
    368 amino acids
    Molecular mass:
    41085 Da
    Cofactor:
    Name=a divalent metal cation; Xref=ChEBI:CHEBI:60240;
    Quaternary structure:
    • Homodimer.
    Miscellaneous:
    • The active site contains 1 hydrated divalent metal cation that has only 1 direct interaction with the protein; all other interactions are via water molecules.

    Three dimensional structures from OCA and Proteopedia for EXOG Gene

    Alternative splice isoforms for EXOG Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for EXOG Gene

Selected DME Specific Peptides for EXOG Gene

Q9Y2C4:
  • AMAETFYLSNIVPQ
  • GAFVVPN

Post-translational modifications for EXOG Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Domains & Families for EXOG Gene

Suggested Antigen Peptide Sequences for EXOG Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9Y2C4

UniProtKB/Swiss-Prot:

EXOG_HUMAN :
  • Belongs to the DNA/RNA non-specific endonuclease family.
Family:
  • Belongs to the DNA/RNA non-specific endonuclease family.
genes like me logo Genes that share domains with EXOG: view

No data available for Gene Families for EXOG Gene

Function for EXOG Gene

Molecular function for EXOG Gene

UniProtKB/Swiss-Prot Function:
Endo/exonuclease with nicking activity towards supercoiled DNA, a preference for single-stranded DNA and 5-3 exonuclease activity.

Enzyme Numbers (IUBMB) for EXOG Gene

Gene Ontology (GO) - Molecular Function for EXOG Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding IEA --
GO:0004518 nuclease activity IEA --
GO:0004519 endonuclease activity NAS,IDA 10231028
GO:0008409 5-3 exonuclease activity IDA 18187503
GO:0016787 hydrolase activity IEA --
genes like me logo Genes that share ontologies with EXOG: view
genes like me logo Genes that share phenotypes with EXOG: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for EXOG Gene

Localization for EXOG Gene

Subcellular locations from UniProtKB/Swiss-Prot for EXOG Gene

Mitochondrion inner membrane.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for EXOG gene
Compartment Confidence
mitochondrion 5
extracellular 2
plasma membrane 1
endoplasmic reticulum 1
lysosome 1
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for EXOG Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005575 cellular_component ND --
GO:0005739 mitochondrion IEA --
GO:0005743 mitochondrial inner membrane IDA 18187503
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with EXOG: view

Pathways & Interactions for EXOG Gene

No Data Available

Gene Ontology (GO) - Biological Process for EXOG Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008150 biological_process ND --
GO:0090305 nucleic acid phosphodiester bond hydrolysis IEA --
genes like me logo Genes that share ontologies with EXOG: view

No data available for Pathways by source and SIGNOR curated interactions for EXOG Gene

Drugs & Compounds for EXOG Gene

No Compound Related Data Available

Transcripts for EXOG Gene

Unigene Clusters for EXOG Gene

Endo/exonuclease (5-3), endonuclease G-like:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for EXOG Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b · 3c · 3d ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b · 8c ^ 9a · 9b ^ 10a · 10b ^ 11a · 11b · 11c · 11d
SP1: - - - - - - -
SP2: - - - - - - -
SP3: - - - - - - - -
SP4: - - - - - -
SP5: - - - - - - - -
SP6: - - - - - - - - -
SP7: - - - - - -
SP8: - - - - - - - - -
SP9:
SP10: - -

Relevant External Links for EXOG Gene

GeneLoc Exon Structure for
EXOG
ECgene alternative splicing isoforms for
EXOG

Expression for EXOG Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for EXOG Gene

mRNA differential expression in normal tissues according to GTEx for EXOG Gene

This gene is overexpressed in Heart - Left Ventricle (x4.1).

Protein differential expression in normal tissues from HIPED for EXOG Gene

This gene is overexpressed in Bone (21.8) and Pancreas (6.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for EXOG Gene



Protein tissue co-expression partners for EXOG Gene

NURSA nuclear receptor signaling pathways regulating expression of EXOG Gene:

EXOG

SOURCE GeneReport for Unigene cluster for EXOG Gene:

Hs.517897

mRNA Expression by UniProt/SwissProt for EXOG Gene:

Q9Y2C4-EXOG_HUMAN
Tissue specificity: Ubiquitous.

Evidence on tissue expression from TISSUES for EXOG Gene

  • Nervous system(4.4)
  • Spleen(4.2)
genes like me logo Genes that share expression patterns with EXOG: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and Phenotype-based relationships between genes and organs from Gene ORGANizer for EXOG Gene

Orthologs for EXOG Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for EXOG Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia EXOG 34 35
  • 99.73 (n)
dog
(Canis familiaris)
Mammalia EXOG 34 35
  • 87.68 (n)
cow
(Bos Taurus)
Mammalia EXOG 34 35
  • 84.6 (n)
rat
(Rattus norvegicus)
Mammalia Exog 34
  • 83.06 (n)
mouse
(Mus musculus)
Mammalia Exog 34 16 35
  • 82.25 (n)
oppossum
(Monodelphis domestica)
Mammalia EXOG 35
  • 61 (a)
OneToOne
chicken
(Gallus gallus)
Aves EXOG 34 35
  • 72.9 (n)
lizard
(Anolis carolinensis)
Reptilia EXOG 35
  • 60 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.20208 34
African clawed frog
(Xenopus laevis)
Amphibia Xl.21178 34
zebrafish
(Danio rerio)
Actinopterygii BX284638.1 35
  • 18 (a)
ManyToMany
Dr.14893 34
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.6888 34
fruit fly
(Drosophila melanogaster)
Insecta Tengl4 35
  • 20 (a)
ManyToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes NUC1 35
  • 31 (a)
OneToMany
Species where no ortholog for EXOG was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for EXOG Gene

ENSEMBL:
Gene Tree for EXOG (if available)
TreeFam:
Gene Tree for EXOG (if available)

Paralogs for EXOG Gene

Paralogs for EXOG Gene

(1) SIMAP similar genes for EXOG Gene using alignment to 9 proteins:

Pseudogenes.org Pseudogenes for EXOG Gene

genes like me logo Genes that share paralogs with EXOG: view

Variants for EXOG Gene

Sequence variations from dbSNP and Humsavar for EXOG Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type
rs1000037963 -- 38,507,385(+) TTCCA(C/G)AGGAT intron-variant
rs1000399044 -- 38,503,463(+) CTGGA(A/C)TAATT intron-variant
rs1000594575 -- 38,522,109(+) CTTTC(A/G)GTAAC intron-variant, reference, synonymous-codon
rs1000742365 -- 38,495,788(+) GAGGC(C/T)GAGGC upstream-variant-2KB
rs1000778515 -- 38,515,505(+) AAGTG(A/G)AAAAT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for EXOG Gene

Variant ID Type Subtype PubMed ID
nsv819153 CNV gain 19587683

Variation tolerance for EXOG Gene

Residual Variation Intolerance Score: 57.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.92; 35.69% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for EXOG Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
EXOG

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for EXOG Gene

Disorders for EXOG Gene

Relevant External Links for EXOG

Genetic Association Database (GAD)
EXOG
Human Genome Epidemiology (HuGE) Navigator
EXOG
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
EXOG

No disorders were found for EXOG Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for EXOG Gene

Publications for EXOG Gene

  1. EXOG, a novel paralog of endonuclease G in higher eukaryotes. (PMID: 18187503) Cymerman I.A. … Meiss G. (Nucleic Acids Res. 2008) 2 3 4 64
  2. Characterization of a 1200-kb genomic segment of chromosome 3p22- p21.3. (PMID: 10231028) Daigo Y. … Nakamura Y. (DNA Res. 1999) 2 3 4 64
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  4. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3 64
  5. Genetic determinants of P wave duration and PR segment. (PMID: 24850809) Verweij N. … van der Harst P. (Circ Cardiovasc Genet 2014) 3 64

Products for EXOG Gene

Sources for EXOG Gene

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