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Aliases for EXOG Gene

Aliases for EXOG Gene

  • Endo/Exonuclease (5'-3'), Endonuclease G-Like 2
  • Endo/Exonuclease (5-3), Endonuclease G-Like 2 3 5
  • Endonuclease G-Like 1 2 3 4
  • Endonuclease G-Like 2 2 3
  • Endo G-Like 1 3 4
  • ENDOGL1 3 4
  • ENDOGL2 3 4
  • ENGL 3 4
  • EC 3.1.30.- 4
  • EC 3.1.30 63
  • ENGL-A 3
  • ENGL-B 3
  • ENGLA 3
  • ENGLB 3

External Ids for EXOG Gene

Previous HGNC Symbols for EXOG Gene


Previous GeneCards Identifiers for EXOG Gene

  • GC03P038513
  • GC03P038537

Summaries for EXOG Gene

Entrez Gene Summary for EXOG Gene

  • This gene encodes an endo/exonuclease with 5'-3' exonuclease activity. The encoded enzyme catalyzes the hydrolysis of ester linkages at the 5' end of a nucleic acid chain. This enzyme is localized to the mitochondria and may play a role in programmed cell death. Alternatively spliced transcript variants have been described. A pseudogene exists on chromosome 18. [provided by RefSeq, Feb 2009]

GeneCards Summary for EXOG Gene

EXOG (Endo/Exonuclease (5'-3'), Endonuclease G-Like) is a Protein Coding gene. GO annotations related to this gene include nucleic acid binding and endonuclease activity. An important paralog of this gene is ENDOG.

UniProtKB/Swiss-Prot for EXOG Gene

  • Endo/exonuclease with nicking activity towards supercoiled DNA, a preference for single-stranded DNA and 5-3 exonuclease activity.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for EXOG Gene

Genomics for EXOG Gene

Regulatory Elements for EXOG Gene

Enhancers for EXOG Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around EXOG on UCSC Golden Path with GeneCards custom track

Promoters for EXOG Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around EXOG on UCSC Golden Path with GeneCards custom track

Genomic Location for EXOG Gene

38,496,127 bp from pter
38,542,161 bp from pter
46,035 bases
Plus strand

Genomic View for EXOG Gene

Genes around EXOG on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
EXOG Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for EXOG Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for EXOG Gene

Proteins for EXOG Gene

  • Protein details for EXOG Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Nuclease EXOG, mitochondrial
    Protein Accession:
    Secondary Accessions:
    • A8K242
    • B4DVG2
    • Q3SXM9
    • Q9Y2C8

    Protein attributes for EXOG Gene

    368 amino acids
    Molecular mass:
    41085 Da
    Name=a divalent metal cation; Xref=ChEBI:CHEBI:60240;
    Quaternary structure:
    • Homodimer.
    • The active site contains 1 hydrated divalent metal cation that has only 1 direct interaction with the protein; all other interactions are via water molecules.

    Three dimensional structures from OCA and Proteopedia for EXOG Gene

    Alternative splice isoforms for EXOG Gene


neXtProt entry for EXOG Gene

Proteomics data for EXOG Gene at MOPED

Selected DME Specific Peptides for EXOG Gene

Post-translational modifications for EXOG Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Antibody Products

Domains & Families for EXOG Gene

Protein Domains for EXOG Gene

Suggested Antigen Peptide Sequences for EXOG Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the DNA/RNA non-specific endonuclease family.
  • Belongs to the DNA/RNA non-specific endonuclease family.
genes like me logo Genes that share domains with EXOG: view

No data available for Gene Families for EXOG Gene

Function for EXOG Gene

Molecular function for EXOG Gene

UniProtKB/Swiss-Prot Function:
Endo/exonuclease with nicking activity towards supercoiled DNA, a preference for single-stranded DNA and 5-3 exonuclease activity.

Enzyme Numbers (IUBMB) for EXOG Gene

Gene Ontology (GO) - Molecular Function for EXOG Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding IEA --
GO:0004519 endonuclease activity NAS 10231028
GO:0016787 hydrolase activity IEA --
genes like me logo Genes that share ontologies with EXOG: view
genes like me logo Genes that share phenotypes with EXOG: view

Animal Model Products

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for EXOG Gene

Localization for EXOG Gene

Subcellular locations from UniProtKB/Swiss-Prot for EXOG Gene

Mitochondrion inner membrane.

Subcellular locations from

Jensen Localization Image for EXOG Gene COMPARTMENTS Subcellular localization image for EXOG gene
Compartment Confidence
mitochondrion 5
extracellular 2
endoplasmic reticulum 1
golgi apparatus 1
lysosome 1
plasma membrane 1
vacuole 1

Gene Ontology (GO) - Cellular Components for EXOG Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with EXOG: view

Pathways & Interactions for EXOG Gene

SuperPathways for EXOG Gene

No Data Available

Gene Ontology (GO) - Biological Process for EXOG Gene


No data available for Pathways by source and SIGNOR curated interactions for EXOG Gene

Drugs & Compounds for EXOG Gene

No Compound Related Data Available

Transcripts for EXOG Gene

Unigene Clusters for EXOG Gene

Endo/exonuclease (5-3), endonuclease G-like:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for EXOG Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b · 3c · 3d ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b · 8c ^ 9a · 9b ^ 10a · 10b ^ 11a · 11b · 11c · 11d
SP1: - - - - - - -
SP2: - - - - - - -
SP3: - - - - - - - -
SP4: - - - - - -
SP5: - - - - - - - -
SP6: - - - - - - - - -
SP7: - - - - - -
SP8: - - - - - - - - -
SP10: - -

Relevant External Links for EXOG Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for EXOG Gene

mRNA expression in normal human tissues for EXOG Gene

mRNA differential expression in normal tissues according to GTEx for EXOG Gene

This gene is overexpressed in Heart - Left Ventricle (x4.1).

Protein differential expression in normal tissues from HIPED for EXOG Gene

This gene is overexpressed in Bone (21.8) and Pancreas (6.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for EXOG Gene

SOURCE GeneReport for Unigene cluster for EXOG Gene Hs.517897

mRNA Expression by UniProt/SwissProt for EXOG Gene

Tissue specificity: Ubiquitous.
genes like me logo Genes that share expression patterns with EXOG: view

Protein tissue co-expression partners for EXOG Gene

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery for EXOG Gene

Orthologs for EXOG Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for EXOG Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia EXOG 35
  • 84.6 (n)
  • 85.33 (a)
  • 85 (a)
(Canis familiaris)
Mammalia EXOG 35
  • 87.68 (n)
  • 85.87 (a)
  • 86 (a)
(Mus musculus)
Mammalia Exog 35
  • 82.25 (n)
  • 83.15 (a)
Exog 16
Exog 36
  • 71 (a)
(Pan troglodytes)
Mammalia EXOG 35
  • 99.73 (n)
  • 99.46 (a)
  • 99 (a)
(Rattus norvegicus)
Mammalia Exog 35
  • 83.06 (n)
  • 82.07 (a)
(Monodelphis domestica)
Mammalia EXOG 36
  • 61 (a)
(Gallus gallus)
Aves EXOG 35
  • 72.9 (n)
  • 71.05 (a)
  • 64 (a)
(Anolis carolinensis)
Reptilia EXOG 36
  • 60 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.20208 35
African clawed frog
(Xenopus laevis)
Amphibia Xl.21178 35
(Danio rerio)
Actinopterygii Dr.14893 35
BX284638.1 36
  • 18 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.6888 35
fruit fly
(Drosophila melanogaster)
Insecta Tengl4 36
  • 20 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes NUC1 36
  • 31 (a)
Species with no ortholog for EXOG:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for EXOG Gene

Gene Tree for EXOG (if available)
Gene Tree for EXOG (if available)

Paralogs for EXOG Gene

Paralogs for EXOG Gene

(1) SIMAP similar genes for EXOG Gene using alignment to 9 proteins: Pseudogenes for EXOG Gene

genes like me logo Genes that share paralogs with EXOG: view

Variants for EXOG Gene

Sequence variations from dbSNP and Humsavar for EXOG Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type
rs1141223 - 38,524,085(+) GTCAG(G/T)ACTGG downstream-variant-500B, reference, missense
rs1065800 -- 38,524,989(+) CCTCT(A/G)TGTAG utr-variant-3-prime
rs1073505 -- 38,525,231(+) TTACC(C/T)GAGTT downstream-variant-500B, utr-variant-3-prime
rs1073506 -- 38,524,744(+) ATTAA(G/T)GGAGC utr-variant-3-prime
rs2284819 -- 38,515,670(+) CCCGC(C/T)ACACC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for EXOG Gene

Variant ID Type Subtype PubMed ID
nsv819153 CNV Gain 19587683

Variation tolerance for EXOG Gene

Residual Variation Intolerance Score: 57.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.92; 35.69% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for EXOG Gene

Disorders for EXOG Gene

Relevant External Links for EXOG

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for EXOG Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for EXOG Gene

Publications for EXOG Gene

  1. EXOG, a novel paralog of endonuclease G in higher eukaryotes. (PMID: 18187503) Cymerman I.A. … Meiss G. (Nucleic Acids Res. 2008) 2 3 4 67
  2. Characterization of a 1200-kb genomic segment of chromosome 3p22- p21.3. (PMID: 10231028) Daigo Y. … Nakamura Y. (DNA Res. 1999) 2 3
  3. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  4. Genetic determinants of P wave duration and PR segment. (PMID: 24850809) Verweij N. … van der Harst P. (Circ Cardiovasc Genet 2014) 3
  5. Identification of three novel genetic variations associated with electrocardiographic traits (QRS duration and PR interval) in East Asians. (PMID: 25035420) Hong K.W. … Oh B. (Hum. Mol. Genet. 2014) 3

Products for EXOG Gene

Sources for EXOG Gene