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Aliases for EXOG Gene

Aliases for EXOG Gene

  • Exo/Endonuclease G 2 3 5
  • Endonuclease G-Like 1 2 3 4
  • Endo/Exonuclease (5-3), Endonuclease G-Like 2 3
  • Endonuclease G-Like 2 2 3
  • Endo G-Like 1 3 4
  • ENDOGL1 3 4
  • ENDOGL2 3 4
  • ENGL 3 4
  • Nuclease EXOG, Mitochondrial 3
  • EC 3.1.30.- 4
  • EC 3.1.30 58
  • ENGL-A 3
  • ENGL-B 3
  • ENGLA 3
  • ENGLB 3

External Ids for EXOG Gene

Previous HGNC Symbols for EXOG Gene


Previous GeneCards Identifiers for EXOG Gene

  • GC03P038513
  • GC03P038537

Summaries for EXOG Gene

Entrez Gene Summary for EXOG Gene

  • This gene encodes an endo/exonuclease with 5'-3' exonuclease activity. The encoded enzyme catalyzes the hydrolysis of ester linkages at the 5' end of a nucleic acid chain. This enzyme is localized to the mitochondria and may play a role in programmed cell death. Alternatively spliced transcript variants have been described. A pseudogene exists on chromosome 18. [provided by RefSeq, Feb 2009]

GeneCards Summary for EXOG Gene

EXOG (Exo/Endonuclease G) is a Protein Coding gene. GO annotations related to this gene include nucleic acid binding and endonuclease activity. An important paralog of this gene is ENDOG.

UniProtKB/Swiss-Prot for EXOG Gene

  • Endo/exonuclease with nicking activity towards supercoiled DNA, a preference for single-stranded DNA and 5-3 exonuclease activity.

Additional gene information for EXOG Gene

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for EXOG Gene

Genomics for EXOG Gene

Regulatory Elements for EXOG Gene

Enhancers for EXOG Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH03H038457 1 Ensembl ENCODE 25.6 -36.4 -36439 4.3 ETV1 ZNF133 MAX ZIC2 RFX5 ZFHX2 SCRT2 EGR2 STAT1 ELF1 EXOG RNU6-1227P ACVR2B-AS1 GC03P038491
GH03H038495 1.1 ENCODE 16.3 +0.2 230 1.9 PKNOX1 ARID4B SIN3A DMAP1 ZNF2 YY1 CBX5 ZNF143 ZHX2 REST EXOG GORASP1 SNORA62 OXSR1 ENSG00000207512 GC03M038505
GH03H038531 1 VISTA dbSUPER 16 +36.8 36842 3.1 NFIC ZNF316 LCORL GATA2 NFIB EXOG PIR46951 PIR44042
GH03H038452 1.1 ENCODE 13.7 -41.4 -41354 4 PKNOX1 ARID4B SIN3A FEZF1 YY1 PAF1 SP3 SP5 MXD4 REST EXOG ACVR2B-AS1 ACVR2B
GH03H038516 0.7 dbSUPER 17.6 +21.1 21051 1.7 PKNOX1 SOX6 MAFG BACH1 DPF2 CEBPG CHAMP1 FOSL1 ZNF316 SMARCA4 EXOG RNU6-1227P DDTP1 PIR53114
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around EXOG on UCSC Golden Path with GeneCards custom track

Promoters for EXOG Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000151010 573 1001 PKNOX1 ARID4B SIN3A DMAP1 ZNF2 YY1 CBX5 ZNF143 ZHX2 REST

Genomic Locations for EXOG Gene

Genomic Locations for EXOG Gene
46,035 bases
Plus strand

Genomic View for EXOG Gene

Genes around EXOG on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
EXOG Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for EXOG Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for EXOG Gene

Proteins for EXOG Gene

  • Protein details for EXOG Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Nuclease EXOG, mitochondrial
    Protein Accession:
    Secondary Accessions:
    • A8K242
    • B4DVG2
    • Q3SXM9
    • Q9Y2C8

    Protein attributes for EXOG Gene

    368 amino acids
    Molecular mass:
    41085 Da
    Name=a divalent metal cation; Xref=ChEBI:CHEBI:60240;
    Quaternary structure:
    • Homodimer.
    • The active site contains 1 hydrated divalent metal cation that has only 1 direct interaction with the protein; all other interactions are via water molecules.

    Three dimensional structures from OCA and Proteopedia for EXOG Gene

    Alternative splice isoforms for EXOG Gene


neXtProt entry for EXOG Gene

Selected DME Specific Peptides for EXOG Gene


Post-translational modifications for EXOG Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Domains & Families for EXOG Gene

Gene Families for EXOG Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Predicted secreted proteins

Suggested Antigen Peptide Sequences for EXOG Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the DNA/RNA non-specific endonuclease family.
  • Belongs to the DNA/RNA non-specific endonuclease family.
genes like me logo Genes that share domains with EXOG: view

Function for EXOG Gene

Molecular function for EXOG Gene

UniProtKB/Swiss-Prot Function:
Endo/exonuclease with nicking activity towards supercoiled DNA, a preference for single-stranded DNA and 5-3 exonuclease activity.

Enzyme Numbers (IUBMB) for EXOG Gene

Phenotypes From GWAS Catalog for EXOG Gene

Gene Ontology (GO) - Molecular Function for EXOG Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding IEA --
GO:0004518 nuclease activity IEA --
GO:0004519 endonuclease activity IDA,NAS 10231028
GO:0008409 5-3 exonuclease activity IDA 18187503
GO:0016787 hydrolase activity IEA --
genes like me logo Genes that share ontologies with EXOG: view
genes like me logo Genes that share phenotypes with EXOG: view

Animal Model Products

Clone Products

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for EXOG Gene

Localization for EXOG Gene

Subcellular locations from UniProtKB/Swiss-Prot for EXOG Gene

Mitochondrion inner membrane.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for EXOG gene
Compartment Confidence
mitochondrion 5
extracellular 2
plasma membrane 1
endoplasmic reticulum 1
lysosome 1
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for EXOG Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005575 cellular_component ND --
GO:0005739 mitochondrion IEA --
GO:0005743 mitochondrial inner membrane IDA 18187503
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with EXOG: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for EXOG Gene

Pathways & Interactions for EXOG Gene

No Data Available

Gene Ontology (GO) - Biological Process for EXOG Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008150 biological_process ND --
GO:0090305 nucleic acid phosphodiester bond hydrolysis IEA --
genes like me logo Genes that share ontologies with EXOG: view

No data available for Pathways by source and SIGNOR curated interactions for EXOG Gene

Drugs & Compounds for EXOG Gene

No Compound Related Data Available

Transcripts for EXOG Gene

Unigene Clusters for EXOG Gene

Endo/exonuclease (5-3), endonuclease G-like:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for EXOG Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b · 3c · 3d ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b · 8c ^ 9a · 9b ^ 10a · 10b ^ 11a · 11b · 11c · 11d
SP1: - - - - - - -
SP2: - - - - - - -
SP3: - - - - - - - -
SP4: - - - - - -
SP5: - - - - - - - -
SP6: - - - - - - - - -
SP7: - - - - - -
SP8: - - - - - - - - -
SP10: - -

Relevant External Links for EXOG Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for EXOG Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for EXOG Gene

mRNA differential expression in normal tissues according to GTEx for EXOG Gene

This gene is overexpressed in Heart - Left Ventricle (x4.1).

Protein differential expression in normal tissues from HIPED for EXOG Gene

This gene is overexpressed in Bone (21.8) and Pancreas (6.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for EXOG Gene

Protein tissue co-expression partners for EXOG Gene

NURSA nuclear receptor signaling pathways regulating expression of EXOG Gene:


SOURCE GeneReport for Unigene cluster for EXOG Gene:


mRNA Expression by UniProt/SwissProt for EXOG Gene:

Tissue specificity: Ubiquitous.

Evidence on tissue expression from TISSUES for EXOG Gene

  • Nervous system(4.4)
  • Spleen(4.2)
genes like me logo Genes that share expression patterns with EXOG: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and Phenotype-based relationships between genes and organs from Gene ORGANizer for EXOG Gene

Orthologs for EXOG Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for EXOG Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia EXOG 33 34
  • 99.73 (n)
(Canis familiaris)
Mammalia EXOG 33 34
  • 87.68 (n)
(Bos Taurus)
Mammalia EXOG 33 34
  • 84.6 (n)
(Rattus norvegicus)
Mammalia Exog 33
  • 83.06 (n)
(Mus musculus)
Mammalia Exog 33 16 34
  • 82.25 (n)
(Monodelphis domestica)
Mammalia EXOG 34
  • 61 (a)
(Gallus gallus)
Aves EXOG 33 34
  • 72.9 (n)
(Anolis carolinensis)
Reptilia EXOG 34
  • 60 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.20208 33
African clawed frog
(Xenopus laevis)
Amphibia Xl.21178 33
(Danio rerio)
Actinopterygii BX284638.1 34
  • 18 (a)
Dr.14893 33
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.6888 33
fruit fly
(Drosophila melanogaster)
Insecta Tengl4 34
  • 20 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes NUC1 34
  • 31 (a)
Species where no ortholog for EXOG was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for EXOG Gene

Gene Tree for EXOG (if available)
Gene Tree for EXOG (if available)

Paralogs for EXOG Gene

Paralogs for EXOG Gene

(1) SIMAP similar genes for EXOG Gene using alignment to 9 proteins: Pseudogenes for EXOG Gene

genes like me logo Genes that share paralogs with EXOG: view

Variants for EXOG Gene

Sequence variations from dbSNP and Humsavar for EXOG Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type
rs1000037963 -- 38,507,385(+) TTCCA(C/G)AGGAT intron-variant
rs1000399044 -- 38,503,463(+) CTGGA(A/C)TAATT intron-variant
rs1000594575 -- 38,522,109(+) CTTTC(A/G)GTAAC intron-variant, reference, synonymous-codon
rs1000742365 -- 38,495,788(+) GAGGC(C/T)GAGGC upstream-variant-2KB
rs1000778515 -- 38,515,505(+) AAGTG(A/G)AAAAT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for EXOG Gene

Variant ID Type Subtype PubMed ID
nsv819153 CNV gain 19587683

Variation tolerance for EXOG Gene

Residual Variation Intolerance Score: 57.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.92; 35.69% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for EXOG Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for EXOG Gene

Disorders for EXOG Gene

Relevant External Links for EXOG

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for EXOG Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for EXOG Gene

Publications for EXOG Gene

  1. EXOG, a novel paralog of Endonuclease G in higher eukaryotes. (PMID: 18187503) Cymerman IA … Meiss G (Nucleic acids research 2008) 2 3 4 60
  2. Characterization of a 1200-kb genomic segment of chromosome 3p22-p21.3. (PMID: 10231028) Daigo Y … Nakamura Y (DNA research : an international journal for rapid publication of reports on genes and genomes 1999) 2 3 4 60
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 60
  4. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 60
  5. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin EL … Gygi SP (Cell 2015) 3 60

Products for EXOG Gene

Sources for EXOG Gene

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