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Aliases for EXOC8 Gene

Aliases for EXOC8 Gene

  • Exocyst Complex Component 8 2 3
  • Exocyst Complex 84 KDa Subunit 3 4
  • EXO84 3 6
  • SEC84 3 6
  • Exo84p 3

External Ids for EXOC8 Gene

Summaries for EXOC8 Gene

GeneCards Summary for EXOC8 Gene

EXOC8 (Exocyst Complex Component 8) is a Protein Coding gene. Among its related pathways are Actin Nucleation by ARP-WASP Complex and Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein. GO annotations related to this gene include phospholipid binding.

UniProtKB/Swiss-Prot for EXOC8 Gene

  • Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane

Gene Wiki entry for EXOC8 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for EXOC8 Gene

Genomics for EXOC8 Gene

Genomic Location for EXOC8 Gene

Start:
231,332,736 bp from pter
End:
231,337,852 bp from pter
Size:
5,117 bases
Orientation:
Minus strand

Genomic View for EXOC8 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for EXOC8 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for EXOC8 Gene

Regulatory Elements for EXOC8 Gene

Proteins for EXOC8 Gene

  • Protein details for EXOC8 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8IYI6-EXOC8_HUMAN
    Recommended name:
    Exocyst complex component 8
    Protein Accession:
    Q8IYI6
    Secondary Accessions:
    • B3KU33
    • Q5TE82

    Protein attributes for EXOC8 Gene

    Size:
    725 amino acids
    Molecular mass:
    81799 Da
    Quaternary structure:
    • The exocyst complex is composed of EXOC1, EXOC2, EXOC3, EXOC4, EXOC5, EXOC6, EXOC7 and EXOC8. Interacts with the GTP-bound forms of RALA and RALB via its PH domain.
    SequenceCaution:
    • Sequence=CAI23095.1; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for EXOC8 Gene

Proteomics data for EXOC8 Gene at MOPED

Post-translational modifications for EXOC8 Gene

  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys29 and Lys60

Other Protein References for EXOC8 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for EXOC8 Gene

Domains for EXOC8 Gene

Protein Domains for EXOC8 Gene

Suggested Antigen Peptide Sequences for EXOC8 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8IYI6

UniProtKB/Swiss-Prot:

EXOC8_HUMAN
Domain:
  • Contains 1 PH domain.:
    • Q8IYI6
Family:
  • Belongs to the EXO84 family.:
    • Q8IYI6
genes like me logo Genes that share domains with EXOC8: view

No data available for Gene Families for EXOC8 Gene

Function for EXOC8 Gene

Molecular function for EXOC8 Gene

UniProtKB/Swiss-Prot Function: Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane

Gene Ontology (GO) - Molecular Function for EXOC8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 16189514
GO:0017160 Ral GTPase binding IPI 24056301
genes like me logo Genes that share ontologies with EXOC8: view

miRNA for EXOC8 Gene

miRTarBase miRNAs that target EXOC8

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for EXOC8 Gene

Localization for EXOC8 Gene

Subcellular locations from UniProtKB/Swiss-Prot for EXOC8 Gene

Cytoplasm. Cell projection, growth cone. Note=Redistributes to growing neurites and growth cones during cell differentiation (By similarity). Binds lipids with phosphatidylinositol 3,4,5-trisphosphate groups. {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for EXOC8 Gene COMPARTMENTS Subcellular localization image for EXOC8 gene
Compartment Confidence
nucleus 4
plasma membrane 4
cytosol 3
mitochondrion 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for EXOC8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000145 exocyst IDA 24056301
GO:0005737 cytoplasm IDA --
GO:0005770 late endosome IDA 24344185
GO:0005829 cytosol TAS --
GO:0005886 plasma membrane TAS --
genes like me logo Genes that share ontologies with EXOC8: view

Pathways for EXOC8 Gene

genes like me logo Genes that share pathways with EXOC8: view

Pathways by source for EXOC8 Gene

Gene Ontology (GO) - Biological Process for EXOC8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001927 exocyst assembly IBA --
GO:0006887 exocytosis --
GO:0006996 organelle organization TAS --
GO:0007032 endosome organization IMP 24344185
GO:0015031 protein transport IEA --
genes like me logo Genes that share ontologies with EXOC8: view

Compounds for EXOC8 Gene

(1) HMDB Compounds for EXOC8 Gene

Compound Synonyms Cas Number PubMed IDs
Guanosine triphosphate
  • 5'-GTP
86-01-1
genes like me logo Genes that share compounds with EXOC8: view

Transcripts for EXOC8 Gene

mRNA/cDNA for EXOC8 Gene

(1) REFSEQ mRNAs :
(2) Additional mRNA sequences :
(46) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for EXOC8 Gene

Exocyst complex component 8:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for EXOC8 Gene

No ASD Table

Relevant External Links for EXOC8 Gene

GeneLoc Exon Structure for
EXOC8
ECgene alternative splicing isoforms for
EXOC8

Expression for EXOC8 Gene

mRNA expression in normal human tissues for EXOC8 Gene

Integrated Proteomics: protein expression from ProteomicsDB, MOPED, and MaxQB for EXOC8 Gene

SOURCE GeneReport for Unigene cluster for EXOC8 Gene Hs.356198

genes like me logo Genes that share expressions with EXOC8: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for EXOC8 Gene

Orthologs for EXOC8 Gene

This gene was present in the common ancestor of animals.

Orthologs for EXOC8 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia EXOC8 35
  • 99.54 (n)
  • 99.86 (a)
EXOC8 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia EXOC8 35
  • 90.07 (n)
  • 97.1 (a)
EXOC8 36
  • 97 (a)
OneToOne
dog
(Canis familiaris)
Mammalia EXOC8 35
  • 90.67 (n)
  • 96.55 (a)
EXOC8 36
  • 98 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Exoc8 35
  • 82.87 (n)
  • 93.58 (a)
Exoc8 16
Exoc8 36
  • 94 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia EXOC8 36
  • 90 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia EXOC8 36
  • 71 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Exoc8 35
  • 83.01 (n)
  • 92.32 (a)
chicken
(Gallus gallus)
Aves EXOC8 35
  • 76.7 (n)
  • 84.8 (a)
EXOC8 36
  • 80 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia EXOC8 36
  • 81 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia exoc8 35
  • 71.91 (n)
  • 78.24 (a)
zebrafish
(Danio rerio)
Actinopterygii exoc8 35
  • 70.53 (n)
  • 77.42 (a)
exoc8 36
  • 77 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP004207 35
  • 43.64 (n)
  • 30 (a)
fruit fly
(Drosophila melanogaster)
Insecta exo84 35
  • 42.59 (n)
  • 30.13 (a)
exo84 36
  • 29 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea exoc-8 35
  • 43.48 (n)
  • 29.11 (a)
exoc-8 36
  • 25 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 41 (a)
OneToOne
Species with no ortholog for EXOC8:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for EXOC8 Gene

ENSEMBL:
Gene Tree for EXOC8 (if available)
TreeFam:
Gene Tree for EXOC8 (if available)

Paralogs for EXOC8 Gene

No data available for Paralogs for EXOC8 Gene

Variants for EXOC8 Gene

Sequence variations from dbSNP and Humsavar for EXOC8 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs953 -- 231,332,860(+) AGTAC(A/G)TGTCA utr-variant-3-prime
rs1062991 -- 231,334,361(-) GATTT(C/T)AGGGT utr-variant-3-prime
rs2053165 -- 231,332,918(-) TTATC(A/G)GCACT utr-variant-3-prime
rs2064766 -- 231,333,207(+) AAACA(A/G)AAGAA utr-variant-3-prime
rs12116889 -- 231,334,238(+) GGCAC(A/C)TTGTC utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for EXOC8 Gene

Variant ID Type Subtype PubMed ID
nsv827197 CNV Loss 20364138

Relevant External Links for EXOC8 Gene

HapMap Linkage Disequilibrium report
EXOC8
Human Gene Mutation Database (HGMD)
EXOC8

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for EXOC8 Gene

Disorders for EXOC8 Gene

No disorders were found for EXOC8 Gene.

No data available for UniProtKB/Swiss-Prot for EXOC8 Gene

Publications for EXOC8 Gene

  1. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory S.G. … Bentley D.R. (Nature 2006) 3 4
  2. Sec5 and Exo84 foster oncogenic ras-mediated tumorigenesis. (PMID: 20145037) Issaq S.H. … Counter C.M. (Mol. Cancer Res. 2010) 3 23
  3. Ral GTPases regulate exocyst assembly through dual subunit interactions. (PMID: 14525976) Moskalenko S. … White M.A. (J. Biol. Chem. 2003) 3 4
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4

Products for EXOC8 Gene

Sources for EXOC8 Gene

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