EXOC8 Gene
protein-coding GIFtS: 53
GCID: GC01M231469
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exocyst complex component 8
| |
Aliases
for EXOC8 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Exocyst Complex Component 81 2 | | EXO841 2 | | Exo84p1 2 | | SEC841 2 | | Exocyst Complex 84 KDa Subunit2 3 | | Exocyst Complex 84-KDa Subunit2 |
Export aliases for EXOC8 gene to outside databasesPrevious GC identifers: GC01M228503 GC01M227775 GC01M229535 GC01M201951 |
Summaries
for EXOC8 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
UniProtKB/Swiss-Prot: EXOC8_HUMAN, Q8IYI6Function: Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasmamembrane
Gene Wiki entry for EXOC8
|
Genomic Views
for EXOC8 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000001.10 NC_018912.1 NT_167186.1
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the EXOC8 gene promoter:
HOXA9B HOXA9 E2F-3a E2F-4 E2F-5 E2F-2 GATA-1 E2F E2F-1 c-Myb
Other transcription factors
Search SABiosciences Chromatin IP Primers for EXOC8
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat EXOC8 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 1q42.2 Ensembl cytogenetic band: 1q42.2 HGNC cytogenetic band: 1q42.2EXOC8 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 1 GeneLoc Exon Structure GeneLoc location for GC01M231469: view genomic region
(about GC identifiers)
Start:
|
231,468,480 bp from pter |
End:
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231,473,598 bp from pter |
Size:
|
5,119 bases |
Orientation:
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minus strand |
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Proteins
for EXOC8 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: EXOC8_HUMAN, Q8IYI6 (See
protein sequence)Recommended Name: Exocyst complex component 8 Size: 725 amino acids; 81799 Da
Subunit: The exocyst complex is composed of EXOC1, EXOC2, EXOC3, EXOC4, EXOC5, EXOC6, EXOC7 and EXOC8. Interacts withthe GTP-bound forms of RALA and RALB via its PH domain
Subcellular location: Cytoplasm. Cell projection, growth cone (By similarity). Note=Redistributes to growing neuritesand growth cones during cell differentiation (By similarity). Binds lipids with phosphatidylinositol3,4,5-trisphosphate groups
Sequence caution: Sequence=CAI23095.1; Type=Erroneous initiation;
Secondary accessions: B3KU33 Q5TE82Explore the universe of human proteins at neXtProt for EXOC8: NX_Q8IYI6
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q8IYI6
EXOC8 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_787072.2
ENSEMBL proteins: ENSP00000355605 ENSP00000353564 Reactome Protein details: Q8IYI6
Human Recombinant Protein Products:
Gene Ontology (GO): 5 cellular component terms (GO ID links to tree view): About this table
EXOC8 for ontologies About GeneDecksing
EXOC8 Antibody Products:
Assay Products for EXOC8: |
Protein
Domains /
Families
for EXOC8 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
EXOC8 for domains About GeneDecksing
4 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q8IYI6ProtoNet protein and cluster: Q8IYI6 1 Blocks protein family: IPB001849 Pleckstrin-like
UniProtKB/Swiss-Prot: EXOC8_HUMAN, Q8IYI6Similarity: Belongs to the EXO84 familySimilarity: Contains 1 PH domain |
Function
for EXOC8 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: EXOC8_HUMAN, Q8IYI6Function: Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasmamembrane
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for EXOC8 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for EXOC8
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: EXOC8 (NM_175876) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for EXOC8 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat EXOC8 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for EXOC8 |
Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005515 | protein binding |
IPI | -- | | GO:0005543 | phospholipid binding |
IEA | -- |
EXOC8 for ontologies About GeneDecksing
|
Pathways & Interactions
for EXOC8 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways - 5/8 super-pathways (see all 8) About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Insulin Processing | | | 2 | Exocyst complex formation | | | 3 | Membrane Trafficking | | | 4 | Cytoskeleton remodeling_RalB regulation pathway | | | 5 | RalA downstream regulated genes | |
Pathway sources
See GeneCards unified pathways
Show all pathways
1 EMD Millipore Pathway for EXOC8
2 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for EXOC8
1  GeneGo (Thomson Reuters) Pathway for EXOC8
1  BioSystems Pathway for EXOC8
5/7 
Reactome Pathways for EXOC8 (see all 7)
EXOC8 for pathways About GeneDecksing
Interactions:
SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for EXOC8
STRING Interaction
Network Preview (showing 5 interactants - click image to see 25)
5/58 Interacting proteins for EXOC8 (Q8IYI61, 2, 3 ENSP000003535644) via UniProtKB, MINT, STRING, and/or I2D (see all 58)| Interactant | Interaction Details |
|---|
| GeneCard | External ID(s) |
|---|
| CCDC85B | Q158342, 3, ENSP000003116954 | MINT-67770 I2D:
score=4 STRING: ENSP00000311695 | | KRT15 | P190122, 3, ENSP000002540434 | MINT-66340 I2D:
score=4 STRING: ENSP00000254043 | | KRT18 | P057832, 3, ENSP000003734874 | MINT-67331 I2D:
score=4 STRING: ENSP00000373487 | | KRT20 | P359002, 3, ENSP000001675884 | MINT-66239 I2D:
score=4 STRING: ENSP00000167588 | | BECN1 | Q144571, 3, ENSP000003552314 | EBI-742102,EBI-949378 I2D:
score=1 STRING: ENSP00000355231 |
About this table
Gene Ontology (GO): 3 biological process terms (GO ID links to tree view): About this table
EXOC8 for ontologies About GeneDecksing
|
Drugs & Compounds
for EXOC8 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for EXOC8
1 HMDB Compound for EXOC8 About this table
Search CenterWatch for drugs/clinical trials and news about EXOC8
|
Transcripts
for EXOC8 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for EXOC8 gene: NM_175876.3 Unigene Cluster for EXOC8: Exocyst complex component 8 Hs.356198 [show with all ESTs]Unigene Representative Sequence: NM_1758762 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000366645 ENST00000360394(uc001huq.3)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for EXOC8 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for EXOC8
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: EXOC8 (NM_175876) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for EXOC8 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat EXOC8 |
Additional cDNA sequence: AK096460.1 BC035763.1 1 DOTS entry: DT.312857 24/46 AceView cDNA sequences (see all 46): Z42829 R56153 AK096460 BM478181 NM_175876 BX281973 BQ010543 AA256879 BI919043 AW891535 AI803940 AI168350 AJ711485 CA407695 AA255473 AA613433 AA749340 Z38971 AA292100 CA775845 BC035763 BM998007 BF366171 BE894563
GeneLoc Exon Structure
|
Expression
for EXOC8 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| EXOC8 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TACTATAAAA
About this image
See EXOC8 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for EXOC8
SOURCE GeneReport for Unigene cluster: Hs.356198
SABiosciences Custom PCR Arrays for EXOC8
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for EXOC8
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat EXOC8 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat EXOC8 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat EXOC8 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for EXOC8 |
Orthologs
for EXOC8 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of eukaryotes.
Orthologs for EXOC8 gene from 10/31 species (see all 31) About this table
ENSEMBL Gene Tree for EXOC8 (if available)
TreeFam Gene Tree for EXOC8 (if available) |
Paralogs
for EXOC8 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| -- |
Genomic Variants
for EXOC8 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 1 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for EXOC8 (231468480 - 231473598 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for EXOC8: --
Human Gene Mutation Database (HGMD): EXOC8
| SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing EXOC8 |
|
Disorders
/ Diseases
for EXOC8 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
EXOC8 for disorders About GeneDecksing
1  disease for EXOC8: About MalaCardsbabesiosis
Export disorders for EXOC8 gene to outside databases
|
Publications
for EXOC8 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for EXOC8 gene, integrated from 9 sources (see all 21):
(articles sorted by number of sources associating them with EXOC8) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)1, 2 Gregory S.G.... Bentley D.R. (2006)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- Ral GTPases regulate exocyst assembly through dual subunit interactions. (PubMed id 14525976)1, 2 Moskalenko S.... White M.A. (2003)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1, 3 Strausberg R.L....Marra M.A. (2002)
- Sec5 and Exo84 foster oncogenic ras-mediated tumorige nesis. (PubMed id 20145037)1, 9 Issaq S.H....Counter C.M. (2010)
- A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (2012)
- Proteomics strategy to identify substrates of LNX, a P DZ domain-containing E3 ubiquitin ligase. (PubMed id 22889411)1 Guo Z....Gao Y. (2012)
- Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)
- A proteome-wide, quantitative survey of in vivo ubiqui tylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (2011)
|
External Searches for EXOC8 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing EXOC8 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing EXOC8 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing EXOC8 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for EXOC8 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for EXOC8 gene:
Search GeneIP for patents involving EXOC8
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for EXOC8 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for EXOC8 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for EXOC8 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for EXOC8 | | | OriGene Protein Over-expression Lysate for EXOC8 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for EXOC8 | | OriGene 3'-UTR Clone for EXOC8 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for EXOC8 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for EXOC8 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | OriGene Purified Protein for EXOC8 | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for EXOC8 | | OriGene Custom Protein Services for EXOC8 | | | OriGene Custom Immunoassay Development | | |
| |
 |
 |
| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat EXOC8 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing EXOC8 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat EXOC8 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat EXOC8 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat EXOC8 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat EXOC8 |
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 |  |  |  | |
| | | | Search Tocris compounds for EXOC8 |
| |  |  |  |  | | | | |
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 | | | EXOC8 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for EXOC8 |
|  |  |  | | | | Search ThermoFisher Antibodies for EXOC8 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat EXOC8 |
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