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EXOC8 Gene

protein-coding   GIFtS: 56
GCID: GC01M231469

Exocyst Complex Component 8

  Search for EXOC8
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Exocyst Complex Component 81 2
Exocyst Complex 84 KDa Subunit2 3
EXO842 5
SEC842 5
Exo84p2
Exocyst Complex 84-KDa Subunit2

External Ids:    HGNC: 246591   Entrez Gene: 1493712   Ensembl: ENSG000001169037   OMIM: 6152835   UniProtKB: Q8IYI63   

Export aliases for EXOC8 gene to outside databases

Previous GC identifers: GC01M228503 GC01M227775 GC01M229535 GC01M201951


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for EXOC8 Gene:
EXOC8 (exocyst complex component 8) is a protein-coding gene. GO annotations related to this gene include phospholipid binding.

UniProtKB/Swiss-Prot: EXOC8_HUMAN, Q8IYI6
Function: Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the
plasma membrane

Gene Wiki entry for EXOC8 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000001.11  NC_018912.2  NT_167186.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the EXOC8 gene promoter:
         HOXA9B   HOXA9   E2F-3a   E2F-4   E2F-5   E2F-2   GATA-1   E2F   E2F-1   c-Myb   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidEXOC8 promoter sequence
   Search Chromatin IP Primers for EXOC8

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat EXOC8


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1q42.2   Ensembl cytogenetic band:  1q42.2   HGNC cytogenetic band: 1q42.2

EXOC8 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
EXOC8 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01M231469:  view genomic region     (about GC identifiers)

Start:
231,468,480 bp from pter      End:
231,473,598 bp from pter
Size:
5,119 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: EXOC8_HUMAN, Q8IYI6 (See protein sequence)
Recommended Name: Exocyst complex component 8  
Size: 725 amino acids; 81799 Da
Subunit: The exocyst complex is composed of EXOC1, EXOC2, EXOC3, EXOC4, EXOC5, EXOC6, EXOC7 and EXOC8. Interacts
with the GTP-bound forms of RALA and RALB via its PH domain
Sequence caution: Sequence=CAI23095.1; Type=Erroneous initiation;
Secondary accessions: B3KU33 Q5TE82

Explore the universe of human proteins at neXtProt for EXOC8: NX_Q8IYI6

Explore proteomics data for EXOC8 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys29, Lys60
  • Modification sites at PhosphoSitePlus

  • See EXOC8 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_787072.2  
    ENSEMBL proteins: 
     ENSP00000355605   ENSP00000353564  
    Reactome Protein details: Q8IYI6

    EXOC8 Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
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    OriGene Purified Protein for EXOC8
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    Novus Biologicals EXOC8 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for EXOC8

     
    Search eBioscience for Proteins for EXOC8 

    EXOC8 Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
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    Abcam antibodies for EXOC8
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    Search ThermoFisher Antibodies for EXOC8
    LSBio Antibodies in human, mouse, rat for EXOC8

    EXOC8 Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for EXOC8
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for EXOC8
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for EXOC8
    Cloud-Clone Corp. CLIAs for EXOC8
    Search eBioscience for ELISAs for EXOC8 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    3 InterPro protein domains:
     IPR016159 Cullin_repeat-like_dom
     IPR001849 Pleckstrin_homology
     IPR011993 PH_like_dom

    Graphical View of Domain Structure for InterPro Entry Q8IYI6

    ProtoNet protein and cluster: Q8IYI6

    1 Blocks protein domain: IPB001849 Pleckstrin-like

    UniProtKB/Swiss-Prot: EXOC8_HUMAN, Q8IYI6
    Similarity: Belongs to the EXO84 family
    Similarity: Contains 1 PH domain


    Find genes that share domains with EXOC8           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: EXOC8_HUMAN, Q8IYI6
    Function: Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the
    plasma membrane

         Gene Ontology (GO): 1 molecular function term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI16189514
         
    Find genes that share ontologies with EXOC8           About GenesLikeMe


    Phenotypes:
         1 MGI phenotypic allele for Exoc8 (no phenotypes)

    Find genes that share phenotypes with EXOC8           About GenesLikeMe

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for EXOC8
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for EXOC8

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for EXOC8
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for EXOC8

    miRNA
    Products:
        
    miRTarBase miRNAs that target EXOC8:
    hsa-mir-615-3p (MIRT039884), hsa-mir-21-5p (MIRT030740), hsa-mir-1226-3p (MIRT036462)

    Block miRNA regulation of human, mouse, rat EXOC8 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate EXOC8 (see all 19):
    hsa-miR-607 hsa-miR-485-3p hsa-miR-1245 hsa-miR-216b hsa-miR-10b* hsa-miR-199b-5p hsa-miR-205* hsa-miR-3915
    SwitchGear 3'UTR luciferase reporter plasmidEXOC8 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for EXOC8
    Predesigned siRNA for gene silencing in human, mouse, rat EXOC8

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for EXOC8

    Clone
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    OriGene clones in human, mouse for EXOC8 (see all 6)
    OriGene ORF clones in mouse, rat for EXOC8
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: EXOC8 (NM_175876)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for EXOC8
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat EXOC8
    Addgene plasmids for EXOC8 

    Cell Line
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    GenScript Custom overexpressing Cell Line Services for EXOC8
    Browse ESI BIO Cell Lines and PureStem Progenitors for EXOC8 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for EXOC8


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    EXOC8_HUMAN, Q8IYI6: Cytoplasm. Cell projection, growth cone (By similarity). Note=Redistributes to growing
    neurites and growth cones during cell differentiation (By similarity). Binds lipids with phosphatidylinositol
    3,4,5-trisphosphate groups
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus4
    plasma membrane4
    cytosol3
    mitochondrion1
    peroxisome1

    Gene Ontology (GO): 5 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000145exocyst IEA--
    GO:0005634nucleus ----
    GO:0005737cytoplasm IDA--
    GO:0005886plasma membrane TAS--
    GO:0030426growth cone IEA--

    Find genes that share ontologies with EXOC8           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for EXOC8 About   (see all 7)  
    See pathways by source

    SuperPathContained pathways About
    1Clathrin derived vesicle budding
    Membrane Trafficking0.32
    Translocation of GLUT4 to the Plasma Membrane0.32
    2Peptide hormone metabolism
    Peptide hormone metabolism0.30
    Insulin Processing0.30
    3Actin Nucleation by ARP-WASP Complex
    CDC42 Pathway0.41
    4Sertoli-Sertoli Cell Junction Dynamics
    Epithelial Tight Junctions0.36
    5Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein
    Metabolism of proteins0.30


    Find genes that share SuperPaths with EXOC8           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    2 Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for EXOC8
        Epithelial Tight Junctions
    CDC42 Pathway

    1 GeneGo (Thomson Reuters) Pathway for EXOC8
        Cytoskeleton remodeling RalB regulation pathway

    1 BioSystems Pathway for EXOC8
        RalA downstream regulated genes

    2 Reactome Pathways for EXOC8
        Translocation of GLUT4 to the plasma membrane
    Insulin processing


        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for EXOC8
    Interactions:

        GeneGlobe Interaction Network for EXOC8

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for EXOC8 (Q8IYI61, 2, 3 ENSP000003535644) via UniProtKB, MINT, STRING, and/or I2D (see all 102)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CCDC85BQ158342, 3, ENSP000003116954MINT-67770 I2D: score=4 STRING: ENSP00000311695
    KRT15P190122, 3, ENSP000002540434MINT-66340 I2D: score=4 STRING: ENSP00000254043
    KRT18P057832, 3, ENSP000003734874MINT-67331 I2D: score=4 STRING: ENSP00000373487
    KRT20P359002, 3, ENSP000001675884MINT-66239 I2D: score=4 STRING: ENSP00000167588
    BECN1Q144571, 3, ENSP000003552314EBI-742102,EBI-949378 I2D: score=1 STRING: ENSP00000355231
    About this table

    Gene Ontology (GO): 5 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006887exocytosis IEA--
    GO:0015031protein transport IEA--
    GO:0034613cellular protein localization IEA--
    GO:0044267cellular protein metabolic process TAS--
    GO:0061024membrane organization TAS--

    Find genes that share ontologies with EXOC8           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for EXOC8

    1 HMDB Compound for EXOC8    About this table
    CompoundSynonyms CAS #PubMed Ids
    Guanosine triphosphate5'-GTP (see all 10)86-01-1--



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for EXOC8 gene: 
    NM_175876.3  

    Unigene Cluster for EXOC8:

    Exocyst complex component 8
    Hs.356198  [show with all ESTs]
    Unigene Representative Sequence: NM_175876
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000366645 ENST00000360394(uc001huq.3)
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat EXOC8 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate EXOC8 (see all 19):
    hsa-miR-607 hsa-miR-485-3p hsa-miR-1245 hsa-miR-216b hsa-miR-10b* hsa-miR-199b-5p hsa-miR-205* hsa-miR-3915
    SwitchGear 3'UTR luciferase reporter plasmidEXOC8 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for EXOC8
    Predesigned siRNA for gene silencing in human, mouse, rat EXOC8
    Clone
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    OriGene clones in human, mouse for EXOC8 (see all 6)
    OriGene ORF clones in mouse, rat for EXOC8
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: EXOC8 (NM_175876)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for EXOC8
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat EXOC8
    Addgene plasmids for EXOC8 
    Primer
    Products:
        
    OriGene qSTAR qPCR primer pairs in human, mouse for EXOC8
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat EXOC8
      QuantiTect SYBR Green Assays in human, mouse, rat EXOC8
      QuantiFast Probe-based Assays in human, mouse, rat EXOC8

    Additional mRNA sequence: 

    AK096460.1 BC035763.1 

    1 DOTS entry:

    DT.312857 

    Selected AceView cDNA sequences (see all 46):

    BM478181 Z42829 AK096460 R56153 NM_175876 AI803940 AA292100 BE894563 
    AA749340 Z38971 BQ010543 AI168350 AA256879 BM998007 BI919043 CA775845 
    BX281973 AW190510 CA407695 N91260 BF366171 AJ711485 AA613433 BQ430357 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    EXOC8 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TACTATAAAA
    EXOC8 Expression
    About this image

    EXOC8 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    EXOC8 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.356198
        Custom PCR Arrays for EXOC8
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for EXOC8

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for EXOC8 gene from Selected species (see all 16)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Exoc81 , 5 exocyst complex component 81, 5 82.87(n)1
    93.58(a)1
      8 (72.82 cM)5
    1020581  NM_198103.21  NP_932771.11 
     1248903005 
    chicken
    (Gallus gallus)
    Aves EXOC81 exocyst complex component 8 76.7(n)
    84.8(a)
      421531  NM_001006404.1  NP_001006404.1 
    lizard
    (Anolis carolinensis)
    Reptilia EXOC86
    exocyst complex component 8
    81(a)
    1 ↔ 1
    1(221761586-221769481)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia BX701091.12   -- 74.75(n)    BX701091.1 
    zebrafish
    (Danio rerio)
    Actinopterygii exoc81 exocyst complex component 8 70.53(n)
    77.42(a)
      568029  NM_001110475.1  NP_001103945.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta exo841 exo84 42.59(n)
    30.13(a)
      43163  NM_143197.2  NP_651454.1 
    worm
    (Caenorhabditis elegans)
    Secernentea exoc-81 exoc-8 43.48(n)
    29.11(a)
      173320  NM_001026531.3  NP_001021702.1 


    ENSEMBL Gene Tree for EXOC8 (if available)
    TreeFam Gene Tree for EXOC8 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for EXOC8 (see all 69)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1879132311,2
    --231468114(+) TTGGGC/TGATAT 1 -- int10--------
    rs349897841,2
    C--231468135(+) AAAAAA/-GGCCA 1 -- int12Minor allele frequency- -:0.25NA 4
    rs752867211,2
    --231468330(+) CTGACA/GGTAAG 1 -- int10--------
    rs1472971071,2
    --231468446(+) AAATAC/TTGAAT 1 -- int10--------
    rs1904008091,2
    --231468475(+) ATAGAC/TATAAT 1 -- int10--------
    rs1165727161,2
    F--231468499(+) TTTTAT/ACCAGT 1 -- ut311Minor allele frequency- A:0.01WA 118
    rs9531,2
    C,F,A,H--231468606(+) AGTACG/ATGTCA 1 -- ut31 ese314Minor allele frequency- A:0.48MN NA EA WA 916
    rs20531651,2
    C,F,O--231468664(-) TTATCG/AGCACT 1 -- ut31 ese32Minor allele frequency- A:0.03NA EA 240
    rs341029911,2
    C--231468771(+) TTCCC-/CAAGAG 1 -- ut310--------
    rs2010336421,2
    C--231468771(-) TTGGGA/GAAAAA 1 -- ut310--------

    HapMap Linkage Disequilibrium report for EXOC8 (231468480 - 231473598 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for EXOC8:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv827197CNV Loss20364138

    Human Gene Mutation Database (HGMD): EXOC8
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing EXOC8
    DNA2.0 Custom Variant and Variant Library Synthesis for EXOC8

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 615283    OMIM disorders: --


    Find genes that share disorders with EXOC8           About GenesLikeMe


    Export disorders for EXOC8 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

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    PubMed articles for EXOC8 gene, integrated from 10 sources (see all 25):
    (articles sorted by number of sources associating them with EXOC8)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)1, 2 Gregory S.G.... Bentley D.R. (Nature 2006)
    2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    4. Ral GTPases regulate exocyst assembly through dual subunit interactions. (PubMed id 14525976)1, 2 Moskalenko S.... White M.A. (J. Biol. Chem. 2003)
    5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1, 3 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)
    6. Sec5 and Exo84 foster oncogenic ras-mediated tumorigenesis. (PubMed id 20145037)1, 9 Issaq S.H....Counter C.M. (Mol. Cancer Res. 2010)
    7. Characterization of the EGFR interactome reveals associated protein complex networks and intracellular receptor dynamics. (PubMed id 23956138)1 Foerster S....Ritter C.A. (Proteomics 2013)
    8. Pathway Analysis of ChIP-Seq-Based NRF1 Target Genes Suggests a Logical Hypothesis of their Involvement in the Pathogenesis of Neurodegenerative Diseases. (PubMed id 24250222)1 Satoh J....Yamamoto Y. (Gene Regul Syst Bio 2013)
    9. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (Cell 2012)
    10. Proteomics strategy to identify substrates of LNX, a PDZ domain-containing E3 ubiquitin ligase. (PubMed id 22889411)1 Guo Z....Gao Y. (J. Proteome Res. 2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
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    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 149371 HGNC: 24659 AceView: EXOC8 Ensembl:ENSG00000116903 euGenes: HUgn149371
    ECgene: EXOC8 H-InvDB: EXOC8

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for EXOC8 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for EXOC8 gene:
    Search GeneIP for patents involving EXOC8

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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