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Aliases for EXOC8 Gene

Aliases for EXOC8 Gene

  • Exocyst Complex Component 8 2 3 5
  • Exocyst Complex 84 KDa Subunit 3 4
  • Exo84p 3
  • EXO84 3
  • SEC84 3

External Ids for EXOC8 Gene

Previous GeneCards Identifiers for EXOC8 Gene

  • GC01M228503
  • GC01M227775
  • GC01M229535
  • GC01M231469
  • GC01M201951

Summaries for EXOC8 Gene

Entrez Gene Summary for EXOC8 Gene

  • This gene encodes a component of the exocyst complex, an evolutionarily conserved multi-protein complex that plays a critical role in vesicular trafficking and the secretory pathway by targeting post-Golgi vesicles to the plasma membrane. This protein is a target of activated Ral subfamily of GTPases and thereby regulates exocytosis by tethering vesicles to the plasma membrane. Mutations in this gene may be related to Joubert syndrome. [provided by RefSeq, Sep 2016]

GeneCards Summary for EXOC8 Gene

EXOC8 (Exocyst Complex Component 8) is a Protein Coding gene. Diseases associated with EXOC8 include Babesiosis. Among its related pathways are Bisphosphonate Pathway, Pharmacodynamics and Organelle biogenesis and maintenance. GO annotations related to this gene include Ral GTPase binding.

UniProtKB/Swiss-Prot for EXOC8 Gene

  • Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane.

Gene Wiki entry for EXOC8 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for EXOC8 Gene

Genomics for EXOC8 Gene

Regulatory Elements for EXOC8 Gene

Enhancers for EXOC8 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH01F231393 1.3 Ensembl ENCODE 10.4 -58.0 -58034 5.4 HDGF PKNOX1 SIN3A ZNF2 YY1 ZNF766 FOS ZNF263 SP3 MXD4 EGLN1 SPRTN C1orf131 EXOC8 GNPAT PIR59803
GH01F231357 1.2 Ensembl ENCODE 10.7 -20.2 -20176 1.1 HDAC1 PKNOX1 WRNIP1 SIN3A ZNF2 RAD21 RFX5 ZNF121 ZNF335 ZNF366 SPRTN EXOC8 DISC1 PIR59803
GH01F231359 0.9 Ensembl ENCODE 10.7 -21.3 -21330 0.4 BHLHE40 MAX CEBPB USF2 ZNF7 RAD51 POLR2A ZNF512 MYC PRDM1 SPRTN EXOC8 DISC1 PIR59803
GH01F230976 1.4 FANTOM5 ENCODE 6.2 +359.2 359245 3.6 HDGF PKNOX1 CREB3L1 ARID4B SIN3A FEZF1 DMAP1 ZNF2 YY1 ZNF143 TTC13 C1orf131 ARV1 EXOC8 FAM89A LOC101927604 SPRTN GC01P230904
GH01F231527 1.8 FANTOM5 Ensembl ENCODE 4.7 -191.3 -191274 4.1 HDGF PKNOX1 ARNT CREB3L1 MLX WRNIP1 ZFP64 ARID4B SIN3A DMAP1 C1orf131 TSNAX GNPAT EXOC8 SPRTN TSNAX-DISC1 GC01P231590 GC01P231591
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around EXOC8 on UCSC Golden Path with GeneCards custom track

Promoters for EXOC8 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000554846 -228 3001 PKNOX1 ARNT CREB3L1 ARID4B SIN3A FEZF1 DMAP1 ZNF2 YY1 ZNF416

Genomic Location for EXOC8 Gene

Chromosome:
1
Start:
231,332,731 bp from pter
End:
231,337,872 bp from pter
Size:
5,142 bases
Orientation:
Minus strand

Genomic View for EXOC8 Gene

Genes around EXOC8 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
EXOC8 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for EXOC8 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for EXOC8 Gene

Proteins for EXOC8 Gene

  • Protein details for EXOC8 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8IYI6-EXOC8_HUMAN
    Recommended name:
    Exocyst complex component 8
    Protein Accession:
    Q8IYI6
    Secondary Accessions:
    • B3KU33
    • Q5TE82

    Protein attributes for EXOC8 Gene

    Size:
    725 amino acids
    Molecular mass:
    81799 Da
    Quaternary structure:
    • The exocyst complex is composed of EXOC1, EXOC2, EXOC3, EXOC4, EXOC5, EXOC6, EXOC7 and EXOC8. Interacts with the GTP-bound forms of RALA and RALB via its PH domain.
    SequenceCaution:
    • Sequence=CAI23095.1; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for EXOC8 Gene

Post-translational modifications for EXOC8 Gene

  • Ubiquitination at Lys 29 and Lys 60
  • Modification sites at PhosphoSitePlus

Other Protein References for EXOC8 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for EXOC8 Gene

Domains & Families for EXOC8 Gene

Gene Families for EXOC8 Gene

Protein Domains for EXOC8 Gene

Suggested Antigen Peptide Sequences for EXOC8 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8IYI6

UniProtKB/Swiss-Prot:

EXOC8_HUMAN :
  • Contains 1 PH domain.
  • Belongs to the EXO84 family.
Domain:
  • Contains 1 PH domain.
Family:
  • Belongs to the EXO84 family.
genes like me logo Genes that share domains with EXOC8: view

Function for EXOC8 Gene

Molecular function for EXOC8 Gene

UniProtKB/Swiss-Prot Function:
Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane.

Gene Ontology (GO) - Molecular Function for EXOC8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 16189514
GO:0017160 Ral GTPase binding IPI 24056301
genes like me logo Genes that share ontologies with EXOC8: view

Phenotypes for EXOC8 Gene

genes like me logo Genes that share phenotypes with EXOC8: view

Animal Models for EXOC8 Gene

MGI Knock Outs for EXOC8:

Animal Model Products

miRNA for EXOC8 Gene

miRTarBase miRNAs that target EXOC8

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for EXOC8

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for EXOC8 Gene

Localization for EXOC8 Gene

Subcellular locations from UniProtKB/Swiss-Prot for EXOC8 Gene

Cytoplasm. Cell projection, growth cone. Note=Redistributes to growing neurites and growth cones during cell differentiation (By similarity). Binds lipids with phosphatidylinositol 3,4,5-trisphosphate groups. {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for EXOC8 gene
Compartment Confidence
plasma membrane 5
cytosol 5
endosome 5
mitochondrion 1
peroxisome 1
nucleus 1

Gene Ontology (GO) - Cellular Components for EXOC8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000145 exocyst IDA 24056301
GO:0005737 cytoplasm IDA --
GO:0005770 late endosome IDA 24344185
GO:0005829 cytosol TAS --
GO:0005886 plasma membrane TAS --
genes like me logo Genes that share ontologies with EXOC8: view

Pathways & Interactions for EXOC8 Gene

genes like me logo Genes that share pathways with EXOC8: view

Pathways by source for EXOC8 Gene

Gene Ontology (GO) - Biological Process for EXOC8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001927 exocyst assembly IBA --
GO:0006810 transport IEA --
GO:0006887 exocytosis IEA --
GO:0007032 endosome organization IMP 24344185
GO:0015031 protein transport IEA --
genes like me logo Genes that share ontologies with EXOC8: view

No data available for SIGNOR curated interactions for EXOC8 Gene

Drugs & Compounds for EXOC8 Gene

(1) Drugs for EXOC8 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Guanosine triphosphate Experimental Pharma 0
genes like me logo Genes that share compounds with EXOC8: view

Transcripts for EXOC8 Gene

mRNA/cDNA for EXOC8 Gene

(1) REFSEQ mRNAs :
(2) Additional mRNA sequences :
(46) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for EXOC8 Gene

Exocyst complex component 8:
Representative Sequences:

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for EXOC8

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for EXOC8 Gene

No ASD Table

Relevant External Links for EXOC8 Gene

GeneLoc Exon Structure for
EXOC8
ECgene alternative splicing isoforms for
EXOC8

Expression for EXOC8 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for EXOC8 Gene

Protein differential expression in normal tissues from HIPED for EXOC8 Gene

This gene is overexpressed in Bone (27.7) and Peripheral blood mononuclear cells (7.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for EXOC8 Gene



Protein tissue co-expression partners for EXOC8 Gene

NURSA nuclear receptor signaling pathways regulating expression of EXOC8 Gene:

EXOC8

SOURCE GeneReport for Unigene cluster for EXOC8 Gene:

Hs.356198
genes like me logo Genes that share expression patterns with EXOC8: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for EXOC8 Gene

Orthologs for EXOC8 Gene

This gene was present in the common ancestor of animals.

Orthologs for EXOC8 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia EXOC8 34 35
  • 99.54 (n)
dog
(Canis familiaris)
Mammalia EXOC8 34 35
  • 90.67 (n)
cow
(Bos Taurus)
Mammalia EXOC8 34 35
  • 90.07 (n)
oppossum
(Monodelphis domestica)
Mammalia EXOC8 35
  • 90 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Exoc8 34
  • 83.01 (n)
mouse
(Mus musculus)
Mammalia Exoc8 34 16 35
  • 82.87 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia EXOC8 35
  • 71 (a)
OneToOne
chicken
(Gallus gallus)
Aves EXOC8 34 35
  • 76.7 (n)
lizard
(Anolis carolinensis)
Reptilia EXOC8 35
  • 81 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia exoc8 34
  • 71.91 (n)
zebrafish
(Danio rerio)
Actinopterygii exoc8 34 35
  • 70.53 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP004207 34
  • 43.64 (n)
fruit fly
(Drosophila melanogaster)
Insecta exo84 34 35
  • 42.59 (n)
worm
(Caenorhabditis elegans)
Secernentea exoc-8 34 35
  • 43.48 (n)
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 41 (a)
OneToOne
Species where no ortholog for EXOC8 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for EXOC8 Gene

ENSEMBL:
Gene Tree for EXOC8 (if available)
TreeFam:
Gene Tree for EXOC8 (if available)

Paralogs for EXOC8 Gene

No data available for Paralogs for EXOC8 Gene

Variants for EXOC8 Gene

Sequence variations from dbSNP and Humsavar for EXOC8 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs483352868 Uncertain significance 231,336,952(+) CATTT(C/T)CGGCC upstream-variant-2KB, reference, missense
rs10489609 -- 231,334,904(+) TTTTA(C/T)ACGGC utr-variant-3-prime
rs1061065 -- 231,339,871(+) GAGGT(A/T)TTTTT intron-variant, upstream-variant-2KB
rs1062991 -- 231,334,361(-) GATTT(C/T)AGGGT utr-variant-3-prime
rs11122272 -- 231,335,026(+) AAAAA(A/G)AGAAG utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for EXOC8 Gene

Variant ID Type Subtype PubMed ID
nsv827197 CNV loss 20364138

Variation tolerance for EXOC8 Gene

Residual Variation Intolerance Score: 10.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.64; 56.75% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for EXOC8 Gene

Human Gene Mutation Database (HGMD)
EXOC8
SNPedia medical, phenotypic, and genealogical associations of SNPs for
EXOC8

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for EXOC8 Gene

Disorders for EXOC8 Gene

MalaCards: The human disease database

(1) MalaCards diseases for EXOC8 Gene - From: DISEASES

Disorder Aliases PubMed IDs
babesiosis
  • babesiasis
- elite association - COSMIC cancer census association via MalaCards
Search EXOC8 in MalaCards View complete list of genes associated with diseases

Relevant External Links for EXOC8

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
EXOC8
genes like me logo Genes that share disorders with EXOC8: view

No data available for UniProtKB/Swiss-Prot and Genatlas for EXOC8 Gene

Publications for EXOC8 Gene

  1. Sec5 and Exo84 foster oncogenic ras-mediated tumorigenesis. (PMID: 20145037) Issaq S.H. … Counter C.M. (Mol. Cancer Res. 2010) 3 22 64
  2. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory S.G. … Bentley D.R. (Nature 2006) 3 4 64
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  5. Ral GTPases regulate exocyst assembly through dual subunit interactions. (PMID: 14525976) Moskalenko S. … White M.A. (J. Biol. Chem. 2003) 3 4 64

Products for EXOC8 Gene

Sources for EXOC8 Gene

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