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Aliases for EXOC7 Gene

Aliases for EXOC7 Gene

  • Exocyst Complex Component 7 2 3 5
  • Exocyst Complex Component Exo70 3 4
  • EXO70 3 4
  • KIAA1067 4
  • YJL085W 3
  • 2-5-3p 3
  • Exo70p 3
  • EX070 3
  • EXOC1 3

External Ids for EXOC7 Gene

Previous GeneCards Identifiers for EXOC7 Gene

  • GC17M074674
  • GC17M071588
  • GC17M074077
  • GC17M069506

Summaries for EXOC7 Gene

Entrez Gene Summary for EXOC7 Gene

  • The protein encoded by this gene is a component of the exocyst complex. The exocyst complex plays a critical role in vesicular trafficking and the secretory pathway by targeting post-Golgi vesicles to the plasma membrane. The encoded protein is required for assembly of the exocyst complex and docking of the complex to the plasma membrane. The encoded protein may also play a role in pre-mRNA splicing through interactions with pre-mRNA-processing factor 19. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene, and a pseudogene of this gene is located on the long arm of chromosome 4. [provided by RefSeq, Nov 2011]

GeneCards Summary for EXOC7 Gene

EXOC7 (Exocyst Complex Component 7) is a Protein Coding gene. Diseases associated with EXOC7 include Bardet-Biedl Syndrome and Bardet-Biedl Syndrome 18. Among its related pathways are Insulin Pathway and Cargo trafficking to the periciliary membrane.

UniProtKB/Swiss-Prot for EXOC7 Gene

  • Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane. In adipocytes, plays a crucial role in targeting SLC2A4 vesicle to the plasma membrane in response to insulin, perhaps directing the vesicle to the precise site of fusion (By similarity).

Gene Wiki entry for EXOC7 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for EXOC7 Gene

Genomics for EXOC7 Gene

Regulatory Elements for EXOC7 Gene

Enhancers for EXOC7 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH17G076258 2 FANTOM5 Ensembl ENCODE dbSUPER 11.3 -146.4 -146400 19.6 AGO1 DMAP1 YY1 ZNF143 SP3 NFYC TBX21 MEF2D ZNF610 ZNF585B RNF157 QRICH2 ENSG00000267342 UBALD2 ENSG00000267546 PRPSAP1 CASKIN2 FOXJ1 EXOC7 PRCD
GH17G076190 1.4 FANTOM5 Ensembl ENCODE 11.2 -70.5 -70458 2.4 TBP TBL1XR1 FEZF1 ZBTB40 RELA ARID3A POLR2A FOXK2 RELB ETV6 RNF157 FOXJ1 EXOC7 AANAT UBE2O RNF157-AS1 UBALD2 ATP5LP6 GC17P076168
GH17G076352 1.4 ENCODE dbSUPER 10.8 -232.5 -232493 2.8 MLX CREB3L1 DMAP1 YY1 SLC30A9 ZNF143 SP3 TBX21 MEF2D ZNF610 PRPSAP1 QRICH2 SPHK1 EXOC7 AANAT UBE2O UNK GC17M076323 GC17M076371
GH17G076181 1.3 Ensembl ENCODE 10.8 -60.7 -60738 0.7 HDGF ATF1 MLX ARNT WRNIP1 ARID4B SIN3A DMAP1 ZNF2 ZNF48 FOXJ1 RNF157 EXOC7 SPHK1 RNF157-AS1 GC17P076168 ATP5LP6
GH17G076178 1.2 Ensembl ENCODE 10.9 -58.2 -58172 1.9 PKNOX1 ATF1 ZNF766 ELK1 ZNF143 ZNF263 REST ZNF592 KAT8 SMARCA4 FOXJ1 EXOC7 SPHK1 RNF157 RNF157-AS1 FBF1 GC17P076168 ATP5LP6
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around EXOC7 on UCSC Golden Path with GeneCards custom track

Genomic Location for EXOC7 Gene

Chromosome:
17
Start:
76,080,993 bp from pter
End:
76,121,576 bp from pter
Size:
40,584 bases
Orientation:
Minus strand

Genomic View for EXOC7 Gene

Genes around EXOC7 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
EXOC7 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for EXOC7 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for EXOC7 Gene

Proteins for EXOC7 Gene

  • Protein details for EXOC7 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9UPT5-EXOC7_HUMAN
    Recommended name:
    Exocyst complex component 7
    Protein Accession:
    Q9UPT5
    Secondary Accessions:
    • B5MC69
    • B8XXP2
    • Q8ND93
    • Q8WV91
    • Q96FF0
    • Q9H8C3
    • Q9H9X3
    • Q9HA32

    Protein attributes for EXOC7 Gene

    Size:
    735 amino acids
    Molecular mass:
    83382 Da
    Quaternary structure:
    • The exocyst complex is composed of EXOC1, EXOC2, EXOC3, EXOC4, EXOC5, EXOC6, EXOC7 and EXOC8. Interacts with ARHQ in a GTP-dependent manner. Interacts with RAB11FIP3 (By similarity).
    SequenceCaution:
    • Sequence=BAA83019.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=BAB14095.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Alternative splice isoforms for EXOC7 Gene

neXtProt entry for EXOC7 Gene

Post-translational modifications for EXOC7 Gene

  • Ubiquitination at Lys40 and Lys65
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for EXOC7 Gene

Domains & Families for EXOC7 Gene

Gene Families for EXOC7 Gene

Protein Domains for EXOC7 Gene

Suggested Antigen Peptide Sequences for EXOC7 Gene

Graphical View of Domain Structure for InterPro Entry

Q9UPT5

UniProtKB/Swiss-Prot:

EXOC7_HUMAN :
  • The N-terminus is involved in SEC8 and ARHQ binding.
  • Belongs to the EXO70 family.
Domain:
  • The N-terminus is involved in SEC8 and ARHQ binding.
  • The C-terminus is required for translocation to the plasma membrane.
Family:
  • Belongs to the EXO70 family.
genes like me logo Genes that share domains with EXOC7: view

Function for EXOC7 Gene

Molecular function for EXOC7 Gene

UniProtKB/Swiss-Prot Function:
Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane. In adipocytes, plays a crucial role in targeting SLC2A4 vesicle to the plasma membrane in response to insulin, perhaps directing the vesicle to the precise site of fusion (By similarity).

Gene Ontology (GO) - Molecular Function for EXOC7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 16148947
genes like me logo Genes that share ontologies with EXOC7: view
genes like me logo Genes that share phenotypes with EXOC7: view

Animal Model Products

  • Taconic Biosciences Mouse Models for EXOC7

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for EXOC7 Gene

Localization for EXOC7 Gene

Subcellular locations from UniProtKB/Swiss-Prot for EXOC7 Gene

Cytoplasm, cytosol. Cell membrane; Peripheral membrane protein. Note=Translocates, as a preformed complex with SEC6 and SEC8, to the plasma membrane in response to insulin through the activation of ARHQ. {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for EXOC7 gene
Compartment Confidence
plasma membrane 5
cytoskeleton 5
cytosol 5
golgi apparatus 3
nucleus 2
endosome 2

Gene Ontology (GO) - Cellular Components for EXOC7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000145 exocyst IEA --
GO:0005737 cytoplasm IEA --
GO:0005815 microtubule organizing center IDA 18000879
GO:0005829 cytosol TAS --
GO:0005886 plasma membrane TAS --
genes like me logo Genes that share ontologies with EXOC7: view

Pathways & Interactions for EXOC7 Gene

genes like me logo Genes that share pathways with EXOC7: view

SIGNOR curated interactions for EXOC7 Gene

Activates:
Is activated by:

Gene Ontology (GO) - Biological Process for EXOC7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006810 transport IEA --
GO:0006887 exocytosis IEA --
GO:0015031 protein transport IEA --
GO:0016241 regulation of macroautophagy TAS 21241894
GO:2000535 regulation of entry of bacterium into host cell IMP 20579884
genes like me logo Genes that share ontologies with EXOC7: view

Drugs & Compounds for EXOC7 Gene

(1) Drugs for EXOC7 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Guanosine triphosphate Experimental Pharma 0
genes like me logo Genes that share compounds with EXOC7: view

Transcripts for EXOC7 Gene

Unigene Clusters for EXOC7 Gene

Exocyst complex component 7:
Representative Sequences:

CRISPR Products

Alternative Splicing Database (ASD) splice patterns (SP) for EXOC7 Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4a · 4b ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10a · 10b ^ 11a · 11b ^ 12 ^ 13a · 13b · 13c · 13d ^ 14 ^ 15a · 15b ^ 16 ^
SP1: - - - - -
SP2: - - -
SP3: - - - -
SP4:
SP5:
SP6: - - -
SP7: - - - -
SP8: - - - - - - - - - - - - - - - - - - - - -
SP9:
SP10: - - - - -
SP11: - - - -
SP12:
SP13: - -
SP14: -
SP15: - - - -

ExUns: 17a · 17b · 17c · 17d ^ 18 ^ 19a · 19b ^ 20a · 20b ^ 21a · 21b · 21c ^ 22 ^ 23 ^ 24a · 24b ^ 25a · 25b ^ 26
SP1: - - -
SP2: - - - - -
SP3: - -
SP4: -
SP5: -
SP6:
SP7:
SP8: - - - - - - - - - - - - - - - -
SP9:
SP10:
SP11:
SP12: -
SP13:
SP14:
SP15:

Relevant External Links for EXOC7 Gene

GeneLoc Exon Structure for
EXOC7
ECgene alternative splicing isoforms for
EXOC7

Expression for EXOC7 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for EXOC7 Gene

Protein differential expression in normal tissues from HIPED for EXOC7 Gene

This gene is overexpressed in Bone (48.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for EXOC7 Gene



Protein tissue co-expression partners for EXOC7 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of EXOC7 Gene:

EXOC7

SOURCE GeneReport for Unigene cluster for EXOC7 Gene:

Hs.514496

Evidence on tissue expression from TISSUES for EXOC7 Gene

  • Nervous system(4.9)
  • Eye(4.3)
genes like me logo Genes that share expression patterns with EXOC7: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for EXOC7 Gene

Orthologs for EXOC7 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for EXOC7 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia EXOC7 35
  • 99 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia EXOC7 35
  • 92 (a)
OneToOne
cow
(Bos Taurus)
Mammalia EXOC7 34 35
  • 91.12 (n)
dog
(Canis familiaris)
Mammalia EXOC7 34 35
  • 90.35 (n)
rat
(Rattus norvegicus)
Mammalia LOC100911734 34
  • 90.25 (n)
mouse
(Mus musculus)
Mammalia Exoc7 34 16 35
  • 89.99 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia EXOC7 35
  • 83 (a)
OneToOne
chicken
(Gallus gallus)
Aves EXOC7 34 35
  • 80.13 (n)
lizard
(Anolis carolinensis)
Reptilia EXOC7 35
  • 85 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.4315 34
zebrafish
(Danio rerio)
Actinopterygii exoc7 34 35
  • 76.12 (n)
wufj67f11 34
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.9364 34
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP006682 34
  • 50.16 (n)
fruit fly
(Drosophila melanogaster)
Insecta exo70 34 35
  • 48.17 (n)
worm
(Caenorhabditis elegans)
Secernentea exoc-7 35
  • 23 (a)
OneToOne
thale cress
(Arabidopsis thaliana)
eudicotyledons EXO70A1 34
  • 43.41 (n)
rice
(Oryza sativa)
Liliopsida Os12g0159700 34
  • 45.62 (n)
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 37 (a)
OneToOne
Species where no ortholog for EXOC7 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for EXOC7 Gene

ENSEMBL:
Gene Tree for EXOC7 (if available)
TreeFam:
Gene Tree for EXOC7 (if available)

Paralogs for EXOC7 Gene

(1) SIMAP similar genes for EXOC7 Gene using alignment to 9 proteins:

Pseudogenes.org Pseudogenes for EXOC7 Gene

genes like me logo Genes that share paralogs with EXOC7: view

No data available for Paralogs for EXOC7 Gene

Variants for EXOC7 Gene

Sequence variations from dbSNP and Humsavar for EXOC7 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type
rs1000024472 -- 76,102,055(+) GTGGT(C/G)TAAGA intron-variant, upstream-variant-2KB
rs1000056516 -- 76,105,965(+) ATGTG(C/T)GTGAG upstream-variant-2KB
rs1000057755 -- 76,104,132(+) GGAGC(A/T)GGTGA upstream-variant-2KB, utr-variant-5-prime
rs1000241750 -- 76,100,918(+) AGAGG(C/T)TGCAG intron-variant, downstream-variant-500B
rs1000309336 -- 76,091,975(+) CAAGT(A/G)AAAAC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for EXOC7 Gene

Variant ID Type Subtype PubMed ID
nsv2142 CNV insertion 18451855
nsv509674 CNV insertion 20534489
nsv833546 CNV loss 17160897

Variation tolerance for EXOC7 Gene

Residual Variation Intolerance Score: 27.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.59; 30.60% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for EXOC7 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
EXOC7

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for EXOC7 Gene

Disorders for EXOC7 Gene

MalaCards: The human disease database

(2) MalaCards diseases for EXOC7 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
bardet-biedl syndrome
  • biedl-bardet syndrome
bardet-biedl syndrome 18
  • bbs18
- elite association - COSMIC cancer census association via MalaCards
Search EXOC7 in MalaCards View complete list of genes associated with diseases

Relevant External Links for EXOC7

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
EXOC7
genes like me logo Genes that share disorders with EXOC7: view

No data available for UniProtKB/Swiss-Prot and Genatlas for EXOC7 Gene

Publications for EXOC7 Gene

  1. Interaction of BIG2, a brefeldin A-inhibited guanine nucleotide- exchange protein, with exocyst protein Exo70. (PMID: 15705715) Xu K.F. … Vaughan M. (Proc. Natl. Acad. Sci. U.S.A. 2005) 3 22 64
  2. Rab11-FIP3 and FIP4 interact with Arf6 and the exocyst to control membrane traffic in cytokinesis. (PMID: 16148947) Fielding A.B. … Gould G.W. (EMBO J. 2005) 3 4 64
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  5. The exocyst complex is required for targeting of Glut4 to the plasma membrane by insulin. (PMID: 12687004) Inoue M. … Saltiel A.R. (Nature 2003) 3 22 64

Products for EXOC7 Gene

  • Addgene plasmids for EXOC7

Sources for EXOC7 Gene

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