Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 



EXOC7 Gene

protein-coding   GIFtS: 61
GCID: GC17M074077

Exocyst Complex Component 7

  See EXOC7-related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

TryGeneCards Plus

Aliases
Exocyst Complex Component 71 2     KIAA10673 5
Exocyst Complex Component Exo702 3     2-5-3p2
EXO702 3     Exo70p2
EX0702 5     YJL085W2
EXOC12 5     

External Ids:    HGNC: 232141   Entrez Gene: 232652   Ensembl: ENSG000001824737   OMIM: 6081635   UniProtKB: Q9UPT53   

Export aliases for EXOC7 gene to outside databases

Previous GC identifers: GC17M074674 GC17M071588 GC17M069506


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

TryGeneCards Plus

Entrez Gene summary for EXOC7 Gene:
The protein encoded by this gene is a component of the exocyst complex. The exocyst complex plays a critical role
in vesicular trafficking and the secretory pathway by targeting post-Golgi vesicles to the plasma membrane. The
encoded protein is required for assembly of the exocyst complex and docking of the complex to the plasma
membrane. The encoded protein may also play a role in pre-mRNA splicing through interactions with
pre-mRNA-processing factor 19. Alternatively spliced transcript variants encoding multiple isoforms have been
observed for this gene, and a pseudogene of this gene is located on the long arm of chromosome 4. (provided by
RefSeq, Nov 2011)

GeneCards Summary for EXOC7 Gene:
EXOC7 (exocyst complex component 7) is a protein-coding gene. Diseases associated with EXOC7 include eastern equine encephalitis.

UniProtKB/Swiss-Prot: EXOC7_HUMAN, Q9UPT5
Function: Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the
plasma membrane. In adipocytes, plays a crucial role in targeting SLC2A4 vesicle to the plasma membrane in
response to insulin, perhaps directing the vesicle to the precise site of fusion (By similarity)

Gene Wiki entry for EXOC7 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

TryGeneCards Plus
RefSeq DNA sequence at NCBI GenBank:
NC_000017.10  NT_010783.16  NC_018928.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the EXOC7 gene promoter:
         SRF   Max1   SRF (504 AA)   Arnt   c-Myc   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidEXOC7 promoter sequence
   Search Chromatin IP Primers for EXOC7

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat EXOC7


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 17q25.1   Ensembl cytogenetic band:  17q25.1   HGNC cytogenetic band: 17q25.3

EXOC7 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
EXOC7 gene location

GeneLoc information about chromosome 17         GeneLoc Exon Structure

GeneLoc location for GC17M074077:  view genomic region     (about GC identifiers)

Start:
74,077,086 bp from pter      End:
74,117,657 bp from pter
Size:
40,572 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
About This Section

TryGeneCards Plus

UniProtKB/Swiss-Prot: EXOC7_HUMAN, Q9UPT5 (See protein sequence)
Recommended Name: Exocyst complex component 7  
Size: 735 amino acids; 83382 Da
Subunit: The exocyst complex is composed of EXOC1, EXOC2, EXOC3, EXOC4, EXOC5, EXOC6, EXOC7 and EXOC8. Interacts
with ARHQ in a GTP-dependent manner. Interacts with RAB11FIP3 (By similarity)
Sequence caution: Sequence=BAA83019.1; Type=Erroneous initiation; Note=Translation N-terminally shortened;
Sequence=BAB14095.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
Secondary accessions: B5MC69 B8XXP2 Q8ND93 Q8WV91 Q96FF0 Q9H8C3 Q9H9X3 Q9HA32
Alternative splicing: 6 isoforms:  Q9UPT5-3   Q9UPT5-1   Q9UPT5-2   Q9UPT5-4   Q9UPT5-5   Q9UPT5-6   (May be due to intron retention. No experimental confirmation available)

Explore the universe of human proteins at neXtProt for EXOC7: NX_Q9UPT5

Explore proteomics data for EXOC7 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys40, Lys65
  • Modification sites at PhosphoSitePlus

  • See EXOC7 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (7 alternative transcripts): 
    NP_001013861.1  NP_001138769.1  NP_001138770.1  NP_001138771.1  NP_001269242.1  NP_001269243.1  NP_056034.2  

    ENSEMBL proteins: 
     ENSP00000333806   ENSP00000468404   ENSP00000334100   ENSP00000466682   ENSP00000384368  
     ENSP00000349767   ENSP00000404322   ENSP00000467042   ENSP00000389950   ENSP00000389723  
     ENSP00000468364   ENSP00000385066   ENSP00000475431  
    Reactome Protein details: Q9UPT5

    EXOC7 Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Proteins for EXOC7
    OriGene Protein Over-expression Lysate for EXOC7
    OriGene MassSpec for EXOC7
    OriGene Custom Protein Services for EXOC7
    GenScript Custom Purified and Recombinant Proteins Services for EXOC7
    Novus Biologicals EXOC7 Protein
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for EXOC7

     
    Search eBioscience for Proteins for EXOC7 

    EXOC7 Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    OriGene Antibodies for EXOC7
    OriGene Custom Antibody Services for EXOC7
    Novus Biologicals EXOC7 Antibodies
    Abcam antibodies for EXOC7
    Cloud-Clone Corp. Antibodies for EXOC7
    ThermoFisher Antibodies for EXOC7
    LSBio Antibodies in human, mouse, rat for EXOC7

    EXOC7 Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for EXOC7
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for EXOC7
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for EXOC7
    Cloud-Clone Corp. CLIAs for EXOC7
    Search eBioscience for ELISAs for EXOC7 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    TryGeneCards Plus
    2 InterPro protein domains:
     IPR016159 Cullin_repeat-like_dom
     IPR004140 Exo70

    Graphical View of Domain Structure for InterPro Entry Q9UPT5

    ProtoNet protein and cluster: Q9UPT5

    1 Blocks protein domain: IPB004140 Exo70 exocyst complex subunit

    UniProtKB/Swiss-Prot: EXOC7_HUMAN, Q9UPT5
    Domain: The N-terminus is involved in SEC8 and ARHQ binding (By similarity)
    Domain: The C-terminus is required for translocation to the plasma membrane (By similarity)
    Similarity: Belongs to the EXO70 family


    Find genes that share domains with EXOC7           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: EXOC7_HUMAN, Q9UPT5
    Function: Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the
    plasma membrane. In adipocytes, plays a crucial role in targeting SLC2A4 vesicle to the plasma membrane in
    response to insulin, perhaps directing the vesicle to the precise site of fusion (By similarity)

         Gene Ontology (GO): 1 molecular function term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI15705715
         
    Find genes that share ontologies with EXOC7           About GenesLikeMe


    Phenotypes:
         3 GenomeRNAi human phenotypes for EXOC7:
     Decreased Salmonella enterica   Increased S DNA content  Increased number of mitotic ce 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for EXOC7
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for EXOC7

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for EXOC7
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for EXOC7

    miRNA
    Products:
        
    miRTarBase miRNAs that target EXOC7:
    hsa-mir-331-3p (MIRT043463), hsa-mir-125b-5p (MIRT045968), hsa-mir-18a-3p (MIRT040867), hsa-mir-615-3p (MIRT040126), hsa-mir-155-5p (MIRT020501)

    Block miRNA regulation of human, mouse, rat EXOC7 using miScript Target Protectors
    6 qRT-PCR Assays for microRNAs that regulate EXOC7:
    hsa-miR-4303 hsa-miR-141 hsa-miR-299-5p hsa-miR-200a hsa-miR-1207-5p hsa-miR-29b-1*
    SwitchGear 3'UTR luciferase reporter plasmidEXOC7 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for EXOC7
    Predesigned siRNA for gene silencing in human, mouse, rat EXOC7

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for EXOC7

    Clone
    Products:
         
    OriGene clones in human, mouse for EXOC7 (see all 34)
    OriGene ORF clones in mouse, rat for EXOC7
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 5): EXOC7 (NM_001145297)
    Sino Biological Human cDNA Clone for EXOC7
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for EXOC7
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat EXOC7
    Addgene plasmids for EXOC7 

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for EXOC7
    Browse ESI BIO Cell Lines and PureStem Progenitors for EXOC7 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for EXOC7


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Subcellular locations from UniProtKB/Swiss-Prot
    EXOC7_HUMAN, Q9UPT5: Cytoplasm, cytosol (By similarity). Cell membrane; Peripheral membrane protein (By
    similarity). Note=Translocates, as a preformed complex with SEC6 and SEC8, to the plasma membrane in response to
    insulin through the activation of ARHQ (By similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane5
    cytoskeleton4
    cytosol3
    golgi apparatus3
    endosome2
    nucleus2

    Gene Ontology (GO): Selected cellular component terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000145exocyst IEA--
    GO:0005815microtubule organizing center IDA18000879
    GO:0005829cytosol IEA--
    GO:0005886plasma membrane TAS--
    GO:0032584growth cone membrane IEA--

    Find genes that share ontologies with EXOC7           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
    About This Section

    TryGeneCards Plus

    SuperPaths for EXOC7 About   (see all 9)  
    See pathways by source

    SuperPathContained pathways About
    1Clathrin derived vesicle budding
    Membrane Trafficking0.32
    Translocation of GLUT4 to the Plasma Membrane0.32
    2Peptide hormone metabolism
    Peptide hormone metabolism0.30
    Insulin Processing0.30
    3Actin Nucleation by ARP-WASP Complex
    CDC42 Pathway0.41
    4Sertoli-Sertoli Cell Junction Dynamics
    Epithelial Tight Junctions0.36
    5CDC42 signaling events
    CDC42 signaling events0.34


    Find genes that share SuperPaths with EXOC7           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    2 Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for EXOC7
        Epithelial Tight Junctions
    CDC42 Pathway

    3 BioSystems Pathways for EXOC7
        CDC42 signaling events
    Arf6 trafficking events
    Insulin Pathway


    2 Reactome Pathways for EXOC7
        Translocation of GLUT4 to the plasma membrane
    Insulin processing


    1 Kegg Pathway  (Kegg details for EXOC7):
        Insulin signaling pathway

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for EXOC7
    Interactions:

        GeneGlobe Interaction Network for EXOC7

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for EXOC7 (Q9UPT51, 2, 3 ENSP000003341004) via UniProtKB, MINT, STRING, and/or I2D (see all 905)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ARFGEF2Q9Y6D51, 2, 3, ENSP000003609854EBI-6251402,EBI-2837511 MINT-7945693 I2D: score=2 STRING: ENSP00000360985
    PRPF19Q9UMS42, 3, ENSP000002275244MINT-7945693 MINT-7947479 I2D: score=4 STRING: ENSP00000227524
    EXOC2Q96KP12, 3, ENSP000002304494MINT-7945693 MINT-7947479 I2D: score=1 STRING: ENSP00000230449
    SPTAN1Q138132, 3MINT-7945693 MINT-7947479 I2D: score=4 
    MAP2K7O147332, 3MINT-7945693 MINT-7947479 I2D: score=2 
    About this table

    Gene Ontology (GO): 4 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006887exocytosis IEA--
    GO:0015031protein transport IEA--
    GO:0044267cellular protein metabolic process TAS--
    GO:0061024membrane organization TAS--

    Find genes that share ontologies with EXOC7           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
    About This Section

    TryGeneCards Plus
    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for EXOC7

    1 HMDB Compound for EXOC7    About this table
    CompoundSynonyms CAS #PubMed Ids
    Guanosine triphosphate5'-GTP (see all 10)86-01-1--



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
    About This Section

    TryGeneCards Plus

    REFSEQ mRNAs for EXOC7 gene (7 alternative transcripts): 
    NM_001013839.3  NM_001145297.3  NM_001145298.3  NM_001145299.3  NM_001282313.1  NM_001282314.1  NM_015219.4  

    Unigene Cluster for EXOC7:

    Exocyst complex component 7
    Hs.514496  [show with all ESTs]
    Unigene Representative Sequence: NM_001145297
    Selected Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 20):
    ENST00000591724 ENST00000332065(uc010dgv.2 uc010wsv.2 uc002jqs.3 uc010wsw.2 uc002jqq.3 uc010wsx.2 uc002jqr.3)
    ENST00000465252(uc002jqp.2) ENST00000589210 ENST00000335146 ENST00000467929
    ENST00000405575 ENST00000467586 ENST00000357231 ENST00000411744 ENST00000494787
    ENST00000460476 ENST00000592559 ENST00000486053 ENST00000405068(uc002jqu.2)
    ENST00000420116 ENST00000442951 ENST00000589507
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat EXOC7 using miScript Target Protectors
    6 qRT-PCR Assays for microRNAs that regulate EXOC7:
    hsa-miR-4303 hsa-miR-141 hsa-miR-299-5p hsa-miR-200a hsa-miR-1207-5p hsa-miR-29b-1*
    SwitchGear 3'UTR luciferase reporter plasmidEXOC7 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for EXOC7
    Predesigned siRNA for gene silencing in human, mouse, rat EXOC7
    Clone
    Products:
         
    OriGene clones in human, mouse for EXOC7 (see all 34)
    OriGene ORF clones in mouse, rat for EXOC7
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 5): EXOC7 (NM_001145297)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for EXOC7
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat EXOC7
    Addgene plasmids for EXOC7 
    Primer
    Products:
        
    OriGene qSTAR qPCR primer pairs in human, mouse for EXOC7
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat EXOC7
      QuantiTect SYBR Green Assays in human, mouse, rat EXOC7
      QuantiFast Probe-based Assays in human, mouse, rat EXOC7

    Additional mRNA sequence: 

    AB028990.1 AK000718.1 AK022552.1 AK023832.1 AK024769.1 AK128278.1 AK295871.1 AL162005.1 
    AL834324.1 AY869728.1 BC011045.1 BC015165.1 BC018466.1 BC029432.1 BC075850.1 BC133668.1 
    BX647763.1 FJ457119.1 FJ457120.1 NR_028133.1 

    Selected DOTS entries (see all 28):

    DT.91763886  DT.427916  DT.100797535  DT.99938690  DT.217247  DT.92014563  DT.95114903  DT.40131335 
    DT.75178113  DT.120960394  DT.86847278  DT.120960352  DT.95264590  DT.91836831  DT.91763888  DT.95264608 
    DT.100797538  DT.102831911  DT.120960385  DT.120960397  DT.65284327  DT.95209604  DT.95264592  DT.95264599 

    Selected AceView cDNA sequences (see all 389):

    AL040966 BG178908 BQ056566 BE784603 BQ712565 BQ230028 BU859103 BU736322 
    BC015165 AU122353 BC018466 BQ007947 BM789176 T23050 BE794436 BU167289 
    BM708712 AI887351 CA842972 BC011045 BX112933 BQ709465 AI682562 AA516133 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for EXOC7 (see all 15)    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4a · 4b ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10a · 10b ^ 11a · 11b ^ 12 ^ 13a · 13b · 13c · 13d ^ 14 ^ 15a · 15b ^ 16 ^
    SP1:                    -     -                             -                             -                 -                                                   
    SP2:                                                        -                             -                 -                                                   
    SP3:                                                                                      -     -     -     -                                                   
    SP4:                                                                                                                                                            
    SP5:                                                                                                                                                            

    ExUns: 17a · 17b · 17c · 17d ^ 18 ^ 19a · 19b ^ 20a · 20b ^ 21a · 21b · 21c ^ 22 ^ 23 ^ 24a · 24b ^ 25a · 25b ^ 26
    SP1:  -                       -                                         -                                             
    SP2:  -                       -     -     -                             -                                             
    SP3:  -                       -                                                                                       
    SP4:  -                                                                                                               
    SP5:  -                                                                                                               


    ECgene alternative splicing isoforms for EXOC7

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TryGeneCards Plus

    EXOC7 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    EXOC7 Expression
    About this image


    EXOC7 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 7) fully expand
     
     Brain (Nervous System)    fully expand to see all 4 entries
             Cerebral Cortex
     
     Trophoblast (Extraembryonic Tissues)
             Trophoblast Cells Trophoblast
     
     Ovary (Reproductive System)
             Oviduct
     
     Pancreas (Endocrine System)
             Islets of Langerhans
     
     Testis (Reproductive System)
             Leydig Cells Testis Interstitium
    EXOC7 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    EXOC7 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.514496
        Custom PCR Arrays for EXOC7
    Primer
    Products:
    OriGene qSTAR qPCR primer pairs in human, mouse for EXOC7
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat EXOC7
    QuantiTect SYBR Green Assays in human, mouse, rat EXOC7
    QuantiFast Probe-based Assays in human, mouse, rat EXOC7
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for EXOC7

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    TryGeneCards Plus

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for EXOC7 gene from Selected species (see all 18)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Exoc71 , 5 exocyst complex component 71, 5 89.99(n)1
    96.48(a)1
      11 (81.11 cM)5
    534131  NM_001162872.11  NP_001156344.11 
     1162880015 
    chicken
    (Gallus gallus)
    Aves EXOC71 exocyst complex component 7 80.13(n)
    88.02(a)
      417361  NM_001012802.1  NP_001012820.1 
    lizard
    (Anolis carolinensis)
    Reptilia EXOC76
    exocyst complex component 7
    85(a)
    1 ↔ 1
    2(113065664-113104464)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia Str.43152 Transcribed sequence with moderate similarity to protein more 77.24(n)    CF346020.1 
    zebrafish
    (Danio rerio)
    Actinopterygii wufj67f112 Danio rerio cDNA clone MGC56575 IMAGE5914866, complete more 78.67(n)    BC052121.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta exo701 exo70 48.17(n)
    35.14(a)
      38959  NM_139965.3  NP_648222.3 
    worm
    (Caenorhabditis elegans)
    Secernentea exoc-76
    Protein EXOC-7 (exoc-7) mRNA, complete cds
    23(a)
    1 ↔ 1
    I(4242819-4247580) WBGene00016606
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons EXO70A11 EXO70A1 43.41(n)
    31.42(a)
      831809  NM_120434.4  NP_195974.2 
    rice
    (Oryza sativa)
    Liliopsida Os12g01597001 Os12g0159700 45.62(n)
    33.14(a)
      4351562  NM_001072744.2  NP_001066212.2 


    ENSEMBL Gene Tree for EXOC7 (if available)
    TreeFam Gene Tree for EXOC7 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

    TryGeneCards Plus
    Paralogs for EXOC7 gene
    1 SIMAP similar gene for EXOC7 using alignment to 9 protein entries:     EXOC7_HUMAN (see all proteins):
    DKFZp686P1551

    Find genes that share paralogs with EXOC7           About GenesLikeMe


    1 Pseudogenes.org Pseudogene for EXOC7
    PGOHUM00000245649


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

    TryGeneCards Plus

    Selected SNPs for EXOC7 (see all 731)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 17 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1916299271,2
    --69530770(+) GGGAGA/GCTGAG 5 -- us2k10--------
    rs356257941,2
    C--74090830(+) AAGTC-/TTTTTT 6 -- int12Minor allele frequency- T:0.25NA CSA 4
    rs340692101,2
    C--74091049(+) TTTTTTT/-GAGAC 6 -- int12Minor allele frequency- -:0.25NA CSA 4
    rs357335591,2
    C--74092879(+) TGATCC/TGCCCA 6 -- int10--------
    rs560573421,2
    C--74094787(+) AAAAA-/ATTAGC 6 -- int11Minor allele frequency- A:0.00NA 2
    rs113277271,2
    C--74097082(+) AACAA-/CAACAA 6 -- int11Minor allele frequency- C:0.00CSA 2
    rs30732251,2
    C--74098499(+) cacac-/ACAC  
            
    acaca
    6 -- int10--------
    rs1135963521,2
    C,F--74100764(+) CGTGCT/CTCAGC 6 -- us2k11Minor allele frequency- C:0.00CSA 1
    rs1122405631,2
    C,F--74101619(+) ACAGGC/TGTGAG 6 -- us2k11Minor allele frequency- T:0.00CSA 1
    rs1393322391,2
    --75160208(+) GGGTGC/TGGGGC 6 -- int10--------

    HapMap Linkage Disequilibrium report for EXOC7 (74077086 - 74117657 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 5 variations for EXOC7:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv2142CNV Insertion18451855
    nsv509674CNV Insertion20534489
    nsv833546CNV Loss17160897
    nsv908824CNV Loss21882294
    dgv3270n71CNV Loss21882294

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing EXOC7
    DNA2.0 Custom Variant and Variant Library Synthesis for EXOC7

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TryGeneCards Plus
    OMIM gene information: 608163    OMIM disorders: --

    1 disease for EXOC7:    
    About MalaCards
    eastern equine encephalitis

    1 disease from the University of Copenhagen DISEASES database for EXOC7:
    Eastern equine encephalitis

    Find genes that share disorders with EXOC7           About GenesLikeMe


    Export disorders for EXOC7 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    TryGeneCards Plus

    PubMed articles for EXOC7 gene, integrated from 10 sources (see all 43):
    (articles sorted by number of sources associating them with EXOC7)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Rab11-FIP3 and FIP4 interact with Arf6 and the exocyst to control membrane traffic in cytokinesis. (PubMed id 16148947)1, 2 Fielding A.B.... Gould G.W. (EMBO J. 2005)
    2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1, 3 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)
    5. Prediction of the coding sequences of unidentified human genes. XIV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 10470851)1, 2 Kikuno R.... Ohara O. (DNA Res. 1999)
    6. Interaction of BIG2, a brefeldin A-inhibited guanine nucleotide- exchange protein, with exocyst protein Exo70. (PubMed id 15705715)1, 9 Xu K.F.... Vaughan M. (Proc. Natl. Acad. Sci. U.S.A. 2005)
    7. The exocyst complex is required for targeting of Glut4 to the plasma membrane by insulin. (PubMed id 12687004)1, 9 Inoue M....Saltiel A.R. (Nature 2003)
    8. Exo70 isoform switching upon epithelial-mesenchymal transition mediates cancer cell invasion. (PubMed id 24331928)1 Lu H....Guo W. (Dev. Cell 2013)
    9. Characterization of the EGFR interactome reveals associated protein complex networks and intracellular receptor dynamics. (PubMed id 23956138)1 Foerster S....Ritter C.A. (Proteomics 2013)
    10. Exo70 generates membrane curvature for morphogenesis and cell migration. (PubMed id 23948253)1 Zhao Y....Guo W. (Dev. Cell 2013)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

    TryGeneCards Plus
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

    TryGeneCards Plus
    Entrez Gene: 23265 HGNC: 23214 AceView: EXOC7 Ensembl:ENSG00000182473 euGenes: HUgn23265
    ECgene: EXOC7 Kegg: 23265 H-InvDB: EXOC7

    (According to HUGE)
    About This Section

    TryGeneCards Plus
    HUGE: KIAA1067

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

    TryGeneCards Plus
    NameDescription
    PharmGKB entry for EXOC7 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus
    Patent Information for EXOC7 gene:
    Search GeneIP for patents involving EXOC7

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

    TryGeneCards Plus

     
     EMD Millipore genomic analysis products

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Enzyme Activity Assays/Reagents  
     Browse ELISpot/FluoroSpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Luminex Assays  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Recombinant/Natural Proteins   Browse Stem Cell Products  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     OriGene Antibodies for EXOC7   OriGene RNAi products in human, mouse, rat for EXOC7  
     Browse OriGene qPCR primer pairs and template standards   OriGene Protein Over-expression Lysate for EXOC7  
     OriGene MassSpec something-or-other for EXOC7   OriGene clones in human, mouse for EXOC7  
     OriGene qSTAR qPCR primer pairs in human, mouse for EXOC7   OriGene Purified Protein for EXOC7  
     OriGene ORF clones in mouse, rat for EXOC7   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for EXOC7   OriGene Custom Protein Services for EXOC7  

     
     
     Block miRNA regulation of human, mouse, rat EXOC7 using miScript Target Protectors SeqTarget long-range PCR primers for resequencing EXOC7
     DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat EXOC7 Predesigned siRNA for gene silencing in human, mouse, rat EXOC7
     QuantiFast Probe-based Assays in human, mouse, rat EXOC7 QuantiTect SYBR Green Assays in human, mouse, rat EXOC7
     Custom PCR Arrays for EXOC7 Search Chromatin IP Primers for EXOC7
     Pre-validated RT2 qPCR Primer Assay in human, mouse, rat EXOC7  GeneGlobe Interaction Network for EXOC7
     Regulatory tfbs in EXOC7 promoter
     GenScript Custom Purified and Recombinant Proteins Services for EXOC7 GenScript cDNA clones with any tag delivered in your preferred vector for EXOC7
     GenScript Custom Assay Services for EXOC7 GenScript Custom overexpressing Cell Line Services for EXOC7
     CloneReady with Over 120,000 Genes  Gene Synthesis: Any Gene in Any Vector
     Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
     Plasmid Preparation Custom Peptide Services
     Search for Antibodies & Assays

     Search Tocris compounds for EXOC7
     Browse Sino Biological Proteins
     Browse Sino Biological Cell Lysates
     cDNA Clones for EXOC7
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

     Novus Tissue Slides
     EXOC7 antibodies
     EXOC7 proteins
     Antibodies for EXOC7
     See all of Abcam's Antibodies, Kits and Proteins for EXOC7
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins
     Proteins for EXOC7
     Antibodies for EXOC7
     ELISAs for EXOC7
     CLIAs for EXOC7



     Browse ESI BIO Cell Lines and PureStem Progenitors for EXOC7
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for EXOC7
     SwitchGear 3'UTR luciferase reporter plasmids for EXOC7
     SwitchGear Promoter luciferase reporter plasmids for EXOC7
     ThermoFisher Antibodies for EXOC7
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat EXOC7
     inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for EXOC7
     inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for EXOC7
     LSBio Antibodies in human, mouse, rat for EXOC7
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
     Browse compounds at ApexBio
     Addgene plasmids for EXOC7
      Search eBioscience for proteins for EXOC7
      Search eBioscience for elisas for EXOC7
      eBioscience FlowRNA Probe Sets
           
    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014 , 21 Aug 2014 , 8 Sep 2014

    View Random Gene

    Category
    (GIFtS: )
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      EXOC7 gene at Home site.
    Version: 3.12.212 17 Sep 2014
    hostname: 356977-web1.xennexinc.com index build: 128 solr: 1.4