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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

EXOC7 Gene

protein-coding   GIFtS: 61
GCID: GC17M074077

Exocyst Complex Component 7

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA

Quality score for the ORGUL clustered with this gene is 3

Aliases
Exocyst Complex Component 71 2     KIAA10673 5
Exocyst Complex Component Exo702 3     2-5-3p2
EXO702 3     Exo70p2
EX0702 5     YJL085W2
EXOC12 5     

External Ids:    HGNC: 232141   Entrez Gene: 232652   Ensembl: ENSG000001824737   OMIM: 6081635   UniProtKB: Q9UPT53   
ORGUL members:         
NONCODE14:n408154      

Export aliases for EXOC7 gene to outside databases

Previous GC identifers: GC17M074674 GC17M071588 GC17M069506


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for EXOC7 Gene:
The protein encoded by this gene is a component of the exocyst complex. The exocyst complex plays a critical role
in vesicular trafficking and the secretory pathway by targeting post-Golgi vesicles to the plasma membrane. The
encoded protein is required for assembly of the exocyst complex and docking of the complex to the plasma
membrane. The encoded protein may also play a role in pre-mRNA splicing through interactions with
pre-mRNA-processing factor 19. Alternatively spliced transcript variants encoding multiple isoforms have been
observed for this gene, and a pseudogene of this gene is located on the long arm of chromosome 4. (provided by
RefSeq, Nov 2011)

GeneCards Summary for EXOC7 Gene: 
EXOC7 (exocyst complex component 7) is a protein-coding gene, and is affiliated with the lncRNA class. Diseases associated with EXOC7 include eastern equine encephalitis, and encephalitis, and among its related super-pathways are Peptide hormone metabolism and Translocation of GLUT4 to the Plasma Membrane. GO annotations related to this gene include protein binding.

UniProtKB/Swiss-Prot: EXOC7_HUMAN, Q9UPT5
Function: Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the
plasma membrane. In adipocytes, plays a crucial role in targeting SLC2A4 vesicle to the plasma membrane in
response to insulin, perhaps directing the vesicle to the precise site of fusion (By similarity)

Gene Wiki entry for EXOC7 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000017.10  NC_018928.2  NT_010783.15  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the EXOC7 gene promoter:
         SRF   Max1   SRF (504 AA)   Arnt   c-Myc   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidEXOC7 promoter sequence
   Search SABiosciences Chromatin IP Primers for EXOC7

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat EXOC7


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 17q25.1   Ensembl cytogenetic band:  17q25.1   HGNC cytogenetic band: 17q25.3

EXOC7 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
EXOC7 gene location

GeneLoc information about chromosome 17         GeneLoc Exon Structure

GeneLoc location for GC17M074077:  view genomic region     (about GC identifiers)

Start:
74,077,086 bp from pter      End:
74,117,657 bp from pter
Size:
40,572 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: EXOC7_HUMAN, Q9UPT5 (See protein sequence)
Recommended Name: Exocyst complex component 7  
Size: 735 amino acids; 83382 Da
Subunit: The exocyst complex is composed of EXOC1, EXOC2, EXOC3, EXOC4, EXOC5, EXOC6, EXOC7 and EXOC8. Interacts
with ARHQ in a GTP-dependent manner. Interacts with RAB11FIP3 (By similarity)
Subcellular location: Cytoplasm, cytosol (By similarity). Cell membrane; Peripheral membrane protein (By
similarity). Note=Translocates, as a preformed complex with SEC6 and SEC8, to the plasma membrane in response to
insulin through the activation of ARHQ (By similarity)
Sequence caution: Sequence=BAA83019.1; Type=Erroneous initiation; Note=Translation N-terminally shortened;
Sequence=BAB14095.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
Secondary accessions: B5MC69 B8XXP2 Q8ND93 Q8WV91 Q96FF0 Q9H8C3 Q9H9X3 Q9HA32
Alternative splicing: 6 isoforms:  Q9UPT5-3   Q9UPT5-1   Q9UPT5-2   Q9UPT5-4   Q9UPT5-5   Q9UPT5-6   (May be due to intron retention. No experimental confirmation available)

Explore the universe of human proteins at neXtProt for EXOC7: NX_Q9UPT5

Explore proteomics data for EXOC7 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q9UPT5

  • EXOC7 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    EXOC7 Protein Expression
    REFSEQ proteins (7 alternative transcripts): 
    NP_001013861.1  NP_001138769.1  NP_001138770.1  NP_001138771.1  NP_001269242.1  NP_001269243.1  NP_056034.2  

    ENSEMBL proteins: 
     ENSP00000333806   ENSP00000468404   ENSP00000334100   ENSP00000466682   ENSP00000384368  
     ENSP00000349767   ENSP00000404322   ENSP00000467042   ENSP00000389950   ENSP00000389723  
     ENSP00000468364   ENSP00000385066   ENSP00000475431  
    Reactome Protein details: Q9UPT5
    Human Recombinant Protein Products for EXOC7: 
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    Novus Biologicals EXOC7 Protein
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    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for EXOC7 

    Gene Ontology (GO): 5/6 cellular component terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000145exocyst IEA--
    GO:0005815microtubule organizing center IDA18000879
    GO:0005829cytosol IEA--
    GO:0005886plasma membrane TAS--
    GO:0032584growth cone membrane IEA--

    EXOC7 for ontologies           About GeneDecksing



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    Cloud-Clone Corp. CLIAs for EXOC7


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    2 InterPro protein domains:
     IPR016159 Cullin_repeat-like_dom
     IPR004140 Exo70

    Graphical View of Domain Structure for InterPro Entry Q9UPT5

    ProtoNet protein and cluster: Q9UPT5

    1 Blocks protein domain: IPB004140 Exo70 exocyst complex subunit

    UniProtKB/Swiss-Prot: EXOC7_HUMAN, Q9UPT5
    Domain: The N-terminus is involved in SEC8 and ARHQ binding (By similarity)
    Domain: The C-terminus is required for translocation to the plasma membrane (By similarity)
    Similarity: Belongs to the EXO70 family


    EXOC7 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: EXOC7_HUMAN, Q9UPT5
    Function: Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the
    plasma membrane. In adipocytes, plays a crucial role in targeting SLC2A4 vesicle to the plasma membrane in
    response to insulin, perhaps directing the vesicle to the precise site of fusion (By similarity)

         Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI15705715
         
    EXOC7 for ontologies           About GeneDecksing


    Phenotypes:
         3 GenomeRNAi human phenotypes for EXOC7:
     Decreased Salmonella enterica   Increased S DNA content  Increased number of mitotic ce 

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for EXOC7 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for EXOC7

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for EXOC7 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for EXOC7 

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat EXOC7
    6 QIAGEN miScript miRNA Assays for microRNAs that regulate EXOC7:
    hsa-miR-4303 hsa-miR-141 hsa-miR-299-5p hsa-miR-200a hsa-miR-1207-5p hsa-miR-29b-1*
    SwitchGear 3'UTR luciferase reporter plasmidEXOC7 3' UTR sequence
    Inhib. RNA
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for EXOC7


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for EXOC7 About   (see all 9)                                                                                              See pathways by source

    SuperPathContained pathways About
    1Insulin Processing
    Peptide hormone metabolism0.39
    Insulin Processing0.39
    2Membrane Trafficking
    Translocation of GLUT4 to the Plasma Membrane0.32
    Membrane Trafficking0.32
    3Actin Nucleation by ARP-WASP Complex
    CDC42 Pathway0.41
    4Sertoli-Sertoli Cell Junction Dynamics
    Epithelial Tight Junctions0.36
    5Asparagine N-linked glycosylation
    Metabolism of proteins0.35

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    2 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for EXOC7
        Epithelial Tight Junctions
    CDC42 Pathway

    3 BioSystems Pathways for EXOC7
        CDC42 signaling events
    Insulin Pathway
    Arf6 trafficking events

    5        Reactome Pathways for EXOC7
        Membrane Trafficking
    Insulin Processing
    Metabolism of proteins
    Translocation of GLUT4 to the Plasma Membrane
    Peptide hormone metabolism


    1         Kegg Pathway  (Kegg details for EXOC7):
        Insulin signaling pathway


    EXOC7 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for EXOC7

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/828 Interacting proteins for EXOC7 (Q9UPT51, 2, 3 ENSP000003341004) via UniProtKB, MINT, STRING, and/or I2D (see all 828)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ARFGEF2Q9Y6D51, 2, 3, ENSP000003609854EBI-6251402,EBI-2837511 MINT-7945693 I2D: score=2 STRING: ENSP00000360985
    PRPF19Q9UMS42, 3, ENSP000002275244MINT-7945693 MINT-7947479 I2D: score=4 STRING: ENSP00000227524
    EXOC2Q96KP12, 3, ENSP000002304494MINT-7945693 MINT-7947479 I2D: score=1 STRING: ENSP00000230449
    SPTAN1Q138132, 3MINT-7945693 MINT-7947479 I2D: score=4 
    MAP2K7O147332, 3MINT-7945693 MINT-7947479 I2D: score=2 
    About this table

    Gene Ontology (GO): 3 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006887exocytosis IEA--
    GO:0015031protein transport IEA--
    GO:0044267cellular protein metabolic process TAS--

    EXOC7 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for EXOC7

    1 HMDB Compound for EXOC7    About this table
    CompoundSynonyms CAS #PubMed Ids
    Guanosine triphosphate5'-GTP (see all 10)86-01-1--

    Search CenterWatch for drugs/clinical trials and news about EXOC7

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for EXOC7 gene (7 alternative transcripts): 
    NM_001013839.3  NM_001145297.3  NM_001145298.3  NM_001145299.3  NM_001282313.1  NM_001282314.1  NM_015219.4  

    Unigene Cluster for EXOC7:

    Exocyst complex component 7
    Hs.514496  [show with all ESTs]
    Unigene Representative Sequence: NM_001145297
    18/20 Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 20):
    ENST00000591724 ENST00000332065(uc010dgv.2 uc010wsv.2 uc002jqs.3 uc010wsw.2 uc002jqq.3 uc010wsx.2 uc002jqr.3)
    ENST00000465252(uc002jqp.2) ENST00000589210 ENST00000335146 ENST00000467929
    ENST00000405575 ENST00000467586 ENST00000357231 ENST00000411744 ENST00000494787
    ENST00000460476 ENST00000592559 ENST00000486053 ENST00000405068(uc002jqu.2)
    ENST00000420116 ENST00000442951 ENST00000589507
    miRNA
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    6 QIAGEN miScript miRNA Assays for microRNAs that regulate EXOC7:
    hsa-miR-4303 hsa-miR-141 hsa-miR-299-5p hsa-miR-200a hsa-miR-1207-5p hsa-miR-29b-1*
    SwitchGear 3'UTR luciferase reporter plasmidEXOC7 3' UTR sequence
    Inhib. RNA
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    DNA2.0 Custom Codon Optimized Gene Synthesis Service for EXOC7
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat EXOC7
    Sirion Biotech Customized lentivirus for stable overexpression of EXOC7 
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    Additional mRNA sequence: 

    AB028990.1 AK000718.1 AK022552.1 AK023832.1 AK024769.1 AK128278.1 AK295871.1 AL162005.1 
    AL834324.1 AY869728.1 BC011045.1 BC015165.1 BC018466.1 BC029432.1 BC075850.1 BC133668.1 
    BX647763.1 FJ457119.1 FJ457120.1 NR_028133.1 

    24/28 DOTS entries (see all 28):

    DT.91763886  DT.427916  DT.100797535  DT.99938690  DT.217247  DT.92014563  DT.95114903  DT.40131335 
    DT.75178113  DT.120960394  DT.86847278  DT.120960352  DT.95264590  DT.91836831  DT.91763888  DT.95264608 
    DT.100797538  DT.102831911  DT.120960385  DT.120960397  DT.65284327  DT.95209604  DT.95264592  DT.95264599 

    24/389 AceView cDNA sequences (see all 389):

    CB131275 AI274792 BQ636766 AW243713 BM014077 AL040966 BG831616 AA551229 
    AL162005 BF446370 BQ945420 T23050 BG178908 BU859103 CA388999 F08250 
    F04479 CA842972 AI566536 BI868714 AI521239 BC018466 CA773786 AU122353 

    GeneLoc Exon Structure

    5/15 Alternative Splicing Database (ASD) splice patterns (SP) for EXOC7 (see all 15)    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4a · 4b ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10a · 10b ^ 11a · 11b ^ 12 ^ 13a · 13b · 13c · 13d ^ 14 ^ 15a · 15b ^ 16 ^
    SP1:                    -     -                             -                             -                 -                                                   
    SP2:                                                        -                             -                 -                                                   
    SP3:                                                                                      -     -     -     -                                                   
    SP4:                                                                                                                                                            
    SP5:                                                                                                                                                            

    ExUns: 17a · 17b · 17c · 17d ^ 18 ^ 19a · 19b ^ 20a · 20b ^ 21a · 21b · 21c ^ 22 ^ 23 ^ 24a · 24b ^ 25a · 25b ^ 26
    SP1:  -                       -                                         -                                             
    SP2:  -                       -     -     -                             -                                             
    SP3:  -                       -                                                                                       
    SP4:  -                                                                                                               
    SP5:  -                                                                                                               


    ECgene alternative splicing isoforms for EXOC7

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    EXOC7 expression in normal human tissues (normalized intensities)      EXOC7 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    EXOC7 Expression
    About this image


    EXOC7 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/33 selected tissues (see all 33) fully expand
     
     Epithelium
             vagina ; squamous epithelial cells   
     
     Testis (Reproductive System)    fully expand to see all 4 entries
             Leydig Cells Testis Interstitium
             seminal vesicle ; glandular cells   
     
     Colon (Gastrointestinal Tract)    fully expand to see all 4 entries
             colon ; peripheral nerve/ganglion   
     
     Brain (Nervous System)    fully expand to see all 4 entries
             Cerebral Cortex
     
     Breast
             breast ; myoepithelial cells   

    See EXOC7 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for EXOC7

    SOURCE GeneReport for Unigene cluster: Hs.514496
        SABiosciences Custom PCR Arrays for EXOC7
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for EXOC7 gene from 10/19 species (see all 19)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Exoc71 , 5 exocyst complex component 71, 5 89.99(n)1
    96.48(a)1
      11 (81.11 cM)5
    534131  NM_001162872.11  NP_001156344.11 
     1162880015 
    chicken
    (Gallus gallus)
    Aves EXOC71 exocyst complex component 7 80.13(n)
    88.02(a)
      417361  NM_001012802.1  NP_001012820.1 
    lizard
    (Anolis carolinensis)
    Reptilia EXOC76
    Uncharacterized protein
    86(a)
    1 ↔ 1
    2(113065664-113104464)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia Str.43152 Transcribed sequence with moderate similarity to protein more 77.24(n)    CF346020.1 
    zebrafish
    (Danio rerio)
    Actinopterygii wufj67f112 Danio rerio cDNA clone MGC56575 IMAGE5914866, complete more 78.67(n)    BC052121.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta exo701 CG7127-PA 48.97(n)
    35.34(a)
      38959  NM_139965.2  NP_648222.3 
    worm
    (Caenorhabditis elegans)
    Secernentea exoc-71 Protein EXOC-7 40.34(n)
    26.63(a)
      172023  NM_058936.3  NP_491337.1 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes EXO706
    Subunit of the exocyst complex (Sec3p, Sec5p, Sec6...
    19(a)
    1 ↔ 1
    X(272827-274698)
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons EXO70A11 exocyst subunit exo70 family protein A1 43(n)
    30.86(a)
      831809  NM_120434.4  NP_195974.2 
    rice
    (Oryza sativa)
    Liliopsida Os11g01574001 hypothetical protein 42.07(n)
    29.72(a)
      4349830  NM_001072333.1  NP_001065801.1 


    ENSEMBL Gene Tree for EXOC7 (if available)
    TreeFam Gene Tree for EXOC7 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for EXOC7 gene
    1 SIMAP similar gene for EXOC7 using alignment to 9 protein entries:     EXOC7_HUMAN (see all proteins):
    DKFZp686P1551

    EXOC7 for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for EXOC7
    PGOHUM00000245649


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/731 SNPs in EXOC7 are shown (see all 731)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 17 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1916299271,2
    --69530770(+) GGGAGA/GCTGAG 5 -- us2k10--------
    rs356257941,2
    C--74090830(+) AAGTC-/TTTTTT 6 -- int12Minor allele frequency- T:0.25NA CSA 4
    rs340692101,2
    C--74091049(+) TTTTTTT/-GAGAC 6 -- int12Minor allele frequency- -:0.25NA CSA 4
    rs357335591,2
    C--74092879(+) TGATCC/TGCCCA 6 -- int10--------
    rs560573421,2
    C--74094787(+) AAAAA-/ATTAGC 6 -- int11Minor allele frequency- A:0.00NA 2
    rs113277271,2
    C--74097082(+) AACAA-/CAACAA 6 -- int11Minor allele frequency- C:0.00CSA 2
    rs30732251,2
    C--74098499(+) cacac-/ACAC  
            
    acaca
    6 -- int10--------
    rs1135963521,2
    C,F--74100764(+) CGTGCT/CTCAGC 6 -- us2k11Minor allele frequency- C:0.00CSA 1
    rs1122405631,2
    C,F--74101619(+) ACAGGC/TGTGAG 6 -- us2k11Minor allele frequency- T:0.00CSA 1
    rs1393322391,2
    --75160208(+) GGGTGC/TGGGGC 6 -- int10--------

    HapMap Linkage Disequilibrium report for EXOC7 (74077086 - 74117657 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 5 variations for EXOC7:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv2142CNV Insertion18451855
    nsv509674CNV Insertion20534489
    nsv833546CNV Loss17160897
    nsv908824CNV Loss21882294
    dgv3270n71CNV Loss21882294

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 608163    OMIM disorders: --

    3 diseases for EXOC7:    About MalaCards
    eastern equine encephalitis    encephalitis    schizophrenia

    1 disease from the University of Copenhagen DISEASES database for EXOC7:
    Eastern equine encephalitis

    EXOC7 for disorders           About GeneDecksing


    Export disorders for EXOC7 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for EXOC7 gene, integrated from 9 sources (see all 40):
    (articles sorted by number of sources associating them with EXOC7)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Rab11-FIP3 and FIP4 interact with Arf6 and the exocyst to control membrane traffic in cytokinesis. (PubMed id 16148947)1, 2 Fielding A.B.... Gould G.W. (2005)
    2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1, 3 Strausberg R.L....Marra M.A. (2002)
    5. Prediction of the coding sequences of unidentified human genes. XIV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 10470851)1, 2 Kikuno R....Ohara O. (1999)
    6. Interaction of BIG2, a brefeldin A-inhibited guanine nucleotide- exchange protein, with exocyst protein Exo70. (PubMed id 15705715)1, 9 Xu K.F.... Vaughan M. (2005)
    7. The exocyst complex is required for targeting of Glut4 to the plasma membrane by insulin. (PubMed id 12687004)1, 9 Inoue M....Saltiel A.R. (2003)
    8. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (2012)
    9. An association between type Ig PI4P 5-kinase and Exo70 directs E-cadherin clustering and epithelial polarization. (PubMed id 22049025)1 Xiong X....Ling K. (2012)
    10. Exo70 subunit of the exocyst complex is involved in ad hesion-dependent trafficking of caveolin-1. (PubMed id 23300727)1 Hertzog M....Chavrier P. (2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 23265 HGNC: 23214 AceView: EXOC7 Ensembl:ENSG00000182473 euGenes: HUgn23265
    ECgene: EXOC7 Kegg: 23265 H-InvDB: EXOC7

    (According to HUGE)
    About This Section
    HUGE: KIAA1067

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for EXOC7 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for EXOC7 gene:
    Search GeneIP for patents involving EXOC7

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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