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Aliases for EXOC6B Gene

Aliases for EXOC6B Gene

  • Exocyst Complex Component 6B 2 3
  • Exocyst Complex Component Sec15B 3 4
  • SEC15-Like Protein 2 3 4
  • SEC15L2 3 4
  • SEC15B 3 4
  • SEC15 Homolog B (S. Cerevisiae) 2
  • SEC15-Like 2 (S. Cerevisiae) 2
  • WUGSC:H_NH0343N14.1 3
  • SEC15 Homolog B 3
  • SEC15-Like 2 3
  • KIAA0919 4

External Ids for EXOC6B Gene

Previous HGNC Symbols for EXOC6B Gene

  • SEC15L2
  • SEC15B

Previous GeneCards Identifiers for EXOC6B Gene

  • GC02M072256
  • GC02M072403

Summaries for EXOC6B Gene

Entrez Gene Summary for EXOC6B Gene

  • In yeast and rat, Sec15 is part of a multiprotein complex that is required for targeted exocytosis.[supplied by OMIM, Apr 2004]

GeneCards Summary for EXOC6B Gene

EXOC6B (Exocyst Complex Component 6B) is a Protein Coding gene. Diseases associated with EXOC6B include renal hypodysplasia/aplasia 1. Among its related pathways are Cytoskeleton remodeling_RalA regulation pathway. An important paralog of this gene is EXOC6.

UniProtKB/Swiss-Prot for EXOC6B Gene

  • Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for EXOC6B Gene

Genomics for EXOC6B Gene

Regulatory Elements for EXOC6B Gene

Genomic Location for EXOC6B Gene

Chromosome:
2
Start:
72,175,984 bp from pter
End:
72,826,048 bp from pter
Size:
650,065 bases
Orientation:
Minus strand

Genomic View for EXOC6B Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for EXOC6B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for EXOC6B Gene

Proteins for EXOC6B Gene

  • Protein details for EXOC6B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9Y2D4-EXC6B_HUMAN
    Recommended name:
    Exocyst complex component 6B
    Protein Accession:
    Q9Y2D4
    Secondary Accessions:
    • B8ZZY3

    Protein attributes for EXOC6B Gene

    Size:
    811 amino acids
    Molecular mass:
    94201 Da
    Quaternary structure:
    • The exocyst complex is composed of SEC3, SEC5, SEC6, SEC8, SEC10, SEC15, EXO70 and EXO84
    SequenceCaution:
    • Sequence=BAA76763.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Alternative splice isoforms for EXOC6B Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for EXOC6B Gene

Proteomics data for EXOC6B Gene at MOPED

Post-translational modifications for EXOC6B Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for EXOC6B Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for EXOC6B Gene

Domains & Families for EXOC6B Gene

Gene Families for EXOC6B Gene

Protein Domains for EXOC6B Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for EXOC6B Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9Y2D4

UniProtKB/Swiss-Prot:

EXC6B_HUMAN :
  • Belongs to the SEC15 family.
Family:
  • Belongs to the SEC15 family.
genes like me logo Genes that share domains with EXOC6B: view

Function for EXOC6B Gene

Molecular function for EXOC6B Gene

UniProtKB/Swiss-Prot Function:
Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane

Phenotypes for EXOC6B Gene

genes like me logo Genes that share phenotypes with EXOC6B: view

Animal Model Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for EXOC6B

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Animal Models , Transcription Factor Targets and HOMER Transcription for EXOC6B Gene

Localization for EXOC6B Gene

Gene Ontology (GO) - Cellular Components for EXOC6B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000145 exocyst IEA --
genes like me logo Genes that share ontologies with EXOC6B: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Subcellular locations from COMPARTMENTS for EXOC6B Gene

Pathways & Interactions for EXOC6B Gene

genes like me logo Genes that share pathways with EXOC6B: view

Pathways by source for EXOC6B Gene

1 GeneGo (Thomson Reuters) pathway for EXOC6B Gene

Gene Ontology (GO) - Biological Process for EXOC6B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006904 vesicle docking involved in exocytosis IEA --
GO:0015031 protein transport IEA --
genes like me logo Genes that share ontologies with EXOC6B: view

No data available for SIGNOR curated interactions for EXOC6B Gene

Drugs & Compounds for EXOC6B Gene

No Compound Related Data Available

Transcripts for EXOC6B Gene

Unigene Clusters for EXOC6B Gene

Exocyst complex component 6B:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for EXOC6B

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for EXOC6B Gene

No ASD Table

Relevant External Links for EXOC6B Gene

GeneLoc Exon Structure for
EXOC6B
ECgene alternative splicing isoforms for
EXOC6B

Expression for EXOC6B Gene

mRNA expression in normal human tissues for EXOC6B Gene

Protein differential expression in normal tissues from HIPED for EXOC6B Gene

This gene is overexpressed in Bone (53.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for EXOC6B Gene



SOURCE GeneReport for Unigene cluster for EXOC6B Gene Hs.303454

genes like me logo Genes that share expression patterns with EXOC6B: view

Protein tissue co-expression partners for EXOC6B Gene

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for EXOC6B Gene

Orthologs for EXOC6B Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for EXOC6B Gene

Organism Taxonomy Gene Similarity Type Details
dog
(Canis familiaris)
Mammalia EXOC6B 35
  • 95.07 (n)
  • 99.51 (a)
EXOC6B 36
  • 96 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Exoc6b 35
  • 92.14 (n)
  • 99.01 (a)
Exoc6b 16
Exoc6b 36
  • 98 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia EXOC6B 35
  • 99.71 (n)
  • 99.88 (a)
EXOC6B 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Exoc6b 35
  • 91.89 (n)
  • 98.77 (a)
cow
(Bos Taurus)
Mammalia EXOC6B 36
  • 99 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia EXOC6B 36
  • 94 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia EXOC6B 36
  • 56 (a)
OneToOne
chicken
(Gallus gallus)
Aves EXOC6B 35
  • 81.6 (n)
  • 93.6 (a)
EXOC6B 36
  • 87 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia EXOC6B 36
  • 86 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia exoc6b 35
  • 75.64 (n)
  • 86.61 (a)
zebrafish
(Danio rerio)
Actinopterygii exoc6b 35
  • 73.67 (n)
  • 79.87 (a)
exoc6b 36
  • 80 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP006648 35
  • 52.91 (n)
  • 46.3 (a)
fruit fly
(Drosophila melanogaster)
Insecta sec15 35
  • 51.8 (n)
  • 44.33 (a)
sec15 36
  • 43 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea sec-15 35
  • 50.17 (n)
  • 39.92 (a)
sec-15 36
  • 38 (a)
OneToMany
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AFR251C 35
  • 40.55 (n)
  • 23.83 (a)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0A01023g 35
  • 40.05 (n)
  • 24.17 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes SEC15 35
  • 41.45 (n)
  • 24.76 (a)
SEC15 36
  • 17 (a)
OneToMany
thale cress
(Arabidopsis thaliana)
eudicotyledons SEC15A 35
  • 43.13 (n)
  • 25.99 (a)
rice
(Oryza sativa)
Liliopsida Os10g0415200 35
  • 43.15 (n)
  • 26.07 (a)
bread mold
(Neurospora crassa)
Ascomycetes NCU00117 35
  • 41.16 (n)
  • 27.17 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes sec15 35
  • 42.23 (n)
  • 25.54 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.3590 36
  • 51 (a)
OneToMany
Species with no ortholog for EXOC6B:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for EXOC6B Gene

ENSEMBL:
Gene Tree for EXOC6B (if available)
TreeFam:
Gene Tree for EXOC6B (if available)

Paralogs for EXOC6B Gene

Paralogs for EXOC6B Gene

(3) SIMAP similar genes for EXOC6B Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with EXOC6B: view

Variants for EXOC6B Gene

Sequence variations from dbSNP and Humsavar for EXOC6B Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type MAF
rs28278 -- 72,198,310(+) TCTCA(C/G)AGAGC intron-variant
rs41386 -- 72,202,647(-) AAAAT(A/G)GGTTT intron-variant
rs41387 -- 72,202,521(-) GCCAT(A/G)TGGAT intron-variant
rs41388 -- 72,201,359(-) TGCTT(C/T)CTGGG intron-variant
rs41389 -- 72,201,250(-) CTTCT(A/G)CGGTG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for EXOC6B Gene

Variant ID Type Subtype PubMed ID
nsv874264 CNV Loss 21882294
nsv2773 CNV Loss 18451855
nsv834257 CNV Gain 17160897
esv2720201 CNV Deletion 23290073
esv2720202 CNV Deletion 23290073
nsv2774 CNV Insertion 18451855
nsv874265 CNV Gain 21882294
esv2661385 CNV Deletion 23128226
esv2425313 CNV Deletion 19546169
nsv2775 CNV Insertion 18451855
esv2670264 CNV Deletion 23128226
nsv834259 CNV Gain 17160897

Variation tolerance for EXOC6B Gene

Residual Variation Intolerance Score: 48.35% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.50; 43.83% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for EXOC6B Gene

HapMap Linkage Disequilibrium report
EXOC6B
Human Gene Mutation Database (HGMD)
EXOC6B

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for EXOC6B Gene

Disorders for EXOC6B Gene

MalaCards: The human disease database

(1) MalaCards diseases for EXOC6B Gene - From: DISEASES

Disorder Aliases PubMed IDs
renal hypodysplasia/aplasia 1
  • renal agenesis
- elite association

Relevant External Links for EXOC6B

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
EXOC6B
genes like me logo Genes that share disorders with EXOC6B: view

No data available for UniProtKB/Swiss-Prot and Genatlas for EXOC6B Gene

Publications for EXOC6B Gene

  1. The brain exocyst complex interacts with RalA in a GTP-dependent manner: identification of a novel mammalian Sec3 gene and a second Sec15 gene. (PMID: 11406615) Brymora A. … Robinson P.J. (J. Biol. Chem. 2001) 2 67
  2. Prediction of the coding sequences of unidentified human genes. XIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 10231032) Nagase T. … Ohara O. (DNA Res. 1999) 2 67
  3. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 67
  4. Temporal proteomics of NGF-TrkA signaling identifies an inhibitory role for the E3 ligase Cbl-b in neuroblastoma cell differentiation. (PMID: 25921289) Emdal K.B. … Olsen J.V. (Sci Signal 2015) 67
  5. Panorama of ancient metazoan macromolecular complexes. (PMID: 26344197) Wan C. … Emili A. (Nature 2015) 67

Products for EXOC6B Gene

Sources for EXOC6B Gene

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