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Aliases for EXOC6B Gene

Aliases for EXOC6B Gene

  • Exocyst Complex Component 6B 2 3 5
  • Exocyst Complex Component Sec15B 3 4
  • SEC15-Like Protein 2 3 4
  • SEC15L2 3 4
  • SEC15B 3 4
  • SEC15 Homolog B (S. Cerevisiae) 2
  • SEC15-Like 2 (S. Cerevisiae) 2
  • SEC15 Homolog B 3
  • KIAA0919 4

External Ids for EXOC6B Gene

Previous HGNC Symbols for EXOC6B Gene

  • SEC15L2
  • SEC15B

Previous GeneCards Identifiers for EXOC6B Gene

  • GC02M072256
  • GC02M072403

Summaries for EXOC6B Gene

Entrez Gene Summary for EXOC6B Gene

  • This gene encodes a protein which is a part of the evolutionarily conserved exocyst, a multimeric protein complex necessary for exocytosis, which in turn, is crucial for cell growth, polarity and migration. Disruption of this gene may be associated with phenotypes exhibiting multiple symptoms including intellectual disability and developmental delay (DD). [provided by RefSeq, Jun 2016]

GeneCards Summary for EXOC6B Gene

EXOC6B (Exocyst Complex Component 6B) is a Protein Coding gene. Diseases associated with EXOC6B include Renal Hypodysplasia/Aplasia 1 and Intellectual Disability. Among its related pathways are Cytoskeleton remodeling_RalA regulation pathway. An important paralog of this gene is EXOC6.

UniProtKB/Swiss-Prot for EXOC6B Gene

  • Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane.

Additional gene information for EXOC6B Gene

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for EXOC6B Gene

Genomics for EXOC6B Gene

Regulatory Elements for EXOC6B Gene

Enhancers for EXOC6B Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH02H072771 0.9 ENCODE 11.1 +55.0 54962 0.1 ELF3 ARID4B DNMT3B ZSCAN9 RAD21 RFX5 ZNF143 CREM THAP11 SMARCA5 EXOC6B SPR ENSG00000212378
GH02H072745 0.8 ENCODE 10.8 +80.1 80102 0.2 CTCF FOXA2 ZNF384 RAD21 RFX5 TEAD3 CC2D1A ZNF316 GATA3 FOXK2 EXOC6B GC02P072760 RNU2-39P
GH02H072793 0.7 Ensembl ENCODE 11.6 +31.7 31748 2 USF2 FOS EXOC6B ENSG00000212378 SPR
GH02H072561 1.3 FANTOM5 Ensembl ENCODE 4.8 +263.8 263752 1.8 TBP SOX13 JUN ZNF7 RFX5 TEAD3 GATA2 POLR2A NFYB DEK CYP26B1 EXOC6B GC02P072603 GC02P072333
GH02H072788 0.5 ENCODE 11.3 +37.1 37062 0.2 ATF7 ATF2 MAFK EXOC6B SPR EMX1 ENSG00000212378
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around EXOC6B on UCSC Golden Path with GeneCards custom track

Promoters for EXOC6B Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000118978 448 1201 HDGF PKNOX1 MLX ARID4B SIN3A ZNF2 ZBTB7B YY1 SLC30A9 ZNF143

Genomic Locations for EXOC6B Gene

Genomic Locations for EXOC6B Gene
650,065 bases
Minus strand

Genomic View for EXOC6B Gene

Genes around EXOC6B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
EXOC6B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for EXOC6B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for EXOC6B Gene

Proteins for EXOC6B Gene

  • Protein details for EXOC6B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Exocyst complex component 6B
    Protein Accession:
    Secondary Accessions:
    • B8ZZY3

    Protein attributes for EXOC6B Gene

    811 amino acids
    Molecular mass:
    94201 Da
    Quaternary structure:
    • The exocyst complex is composed of SEC3, SEC5, SEC6, SEC8, SEC10, SEC15, EXO70 and EXO84.
    • Sequence=BAA76763.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Alternative splice isoforms for EXOC6B Gene


neXtProt entry for EXOC6B Gene

Post-translational modifications for EXOC6B Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for EXOC6B Gene

Domains & Families for EXOC6B Gene

Gene Families for EXOC6B Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for EXOC6B Gene

Suggested Antigen Peptide Sequences for EXOC6B Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the SEC15 family.
  • Belongs to the SEC15 family.
genes like me logo Genes that share domains with EXOC6B: view

Function for EXOC6B Gene

Molecular function for EXOC6B Gene

UniProtKB/Swiss-Prot Function:
Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane.

Phenotypes From GWAS Catalog for EXOC6B Gene

Gene Ontology (GO) - Molecular Function for EXOC6B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 27173435
genes like me logo Genes that share ontologies with EXOC6B: view

Phenotypes for EXOC6B Gene

genes like me logo Genes that share phenotypes with EXOC6B: view

Animal Model Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for EXOC6B Gene

Localization for EXOC6B Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for EXOC6B gene
Compartment Confidence
cytosol 3
nucleus 2
peroxisome 1
golgi apparatus 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (2)
  • Nuclear bodies (2)
  • Nucleoplasm (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for EXOC6B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000145 exocyst IEA --
genes like me logo Genes that share ontologies with EXOC6B: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for EXOC6B Gene

Pathways & Interactions for EXOC6B Gene

genes like me logo Genes that share pathways with EXOC6B: view

Pathways by source for EXOC6B Gene

1 GeneGo (Thomson Reuters) pathway for EXOC6B Gene

Gene Ontology (GO) - Biological Process for EXOC6B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006810 transport IEA --
GO:0006887 exocytosis IEA --
GO:0006904 vesicle docking involved in exocytosis IEA --
GO:0015031 protein transport IEA --
genes like me logo Genes that share ontologies with EXOC6B: view

No data available for SIGNOR curated interactions for EXOC6B Gene

Drugs & Compounds for EXOC6B Gene

No Compound Related Data Available

Transcripts for EXOC6B Gene

Unigene Clusters for EXOC6B Gene

Exocyst complex component 6B:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for EXOC6B Gene

No ASD Table

Relevant External Links for EXOC6B Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for EXOC6B Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for EXOC6B Gene

Protein differential expression in normal tissues from HIPED for EXOC6B Gene

This gene is overexpressed in Bone (53.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for EXOC6B Gene

Protein tissue co-expression partners for EXOC6B Gene

NURSA nuclear receptor signaling pathways regulating expression of EXOC6B Gene:


SOURCE GeneReport for Unigene cluster for EXOC6B Gene:


Evidence on tissue expression from TISSUES for EXOC6B Gene

  • Nervous system(4.7)
  • Heart(2.1)
genes like me logo Genes that share expression patterns with EXOC6B: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for EXOC6B Gene

Orthologs for EXOC6B Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for EXOC6B Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia EXOC6B 34 33
  • 99.71 (n)
(Bos Taurus)
Mammalia EXOC6B 34
  • 99 (a)
(Canis familiaris)
Mammalia EXOC6B 34 33
  • 95.07 (n)
(Monodelphis domestica)
Mammalia EXOC6B 34
  • 94 (a)
(Mus musculus)
Mammalia Exoc6b 16 34 33
  • 92.14 (n)
(Rattus norvegicus)
Mammalia Exoc6b 33
  • 91.89 (n)
(Ornithorhynchus anatinus)
Mammalia EXOC6B 34
  • 56 (a)
(Gallus gallus)
Aves EXOC6B 34 33
  • 81.6 (n)
(Anolis carolinensis)
Reptilia EXOC6B 34
  • 86 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia exoc6b 33
  • 75.64 (n)
(Danio rerio)
Actinopterygii exoc6b 34 33
  • 73.67 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP006648 33
  • 52.91 (n)
fruit fly
(Drosophila melanogaster)
Insecta sec15 33 34
  • 51.8 (n)
(Caenorhabditis elegans)
Secernentea sec-15 33 34
  • 50.17 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes SEC15 33 34
  • 41.45 (n)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AFR251C 33
  • 40.55 (n)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0A01023g 33
  • 40.05 (n)
thale cress
(Arabidopsis thaliana)
eudicotyledons SEC15A 33
  • 43.13 (n)
(Oryza sativa)
Liliopsida Os10g0414950 33
  • 43.15 (n)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.3590 34
  • 51 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes sec15 33
  • 42.23 (n)
bread mold
(Neurospora crassa)
Ascomycetes NCU00117 33
  • 41.16 (n)
Species where no ortholog for EXOC6B was found in the sources mined by GeneCards:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for EXOC6B Gene

Gene Tree for EXOC6B (if available)
Gene Tree for EXOC6B (if available)

Paralogs for EXOC6B Gene

Paralogs for EXOC6B Gene

(3) SIMAP similar genes for EXOC6B Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with EXOC6B: view

Variants for EXOC6B Gene

Sequence variations from dbSNP and Humsavar for EXOC6B Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type
rs864309603 Uncertain significance 72,559,482(-) CAGTT(G/T)ATCGA nc-transcript-variant, reference, missense, utr-variant-5-prime
rs1000002759 -- 72,558,535(+) GGAGA(C/G)CCAGA intron-variant
rs1000007664 -- 72,375,892(+) GCTTG(C/T)TTAAG intron-variant
rs1000008888 -- 72,413,829(+) CACCT(A/G)GTGAG intron-variant
rs1000010997 -- 72,784,089(+) TATTG(A/T)TTAAA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for EXOC6B Gene

Variant ID Type Subtype PubMed ID
nsv961792 CNV duplication 23825009
nsv834259 CNV gain 17160897
nsv834257 CNV gain 17160897
nsv582208 CNV loss 21841781
nsv477760 CNV novel sequence insertion 20440878
nsv2775 CNV insertion 18451855
nsv2774 CNV insertion 18451855
nsv2773 CNV deletion 18451855
esv3892659 CNV loss 25118596
esv3591247 CNV loss 21293372
esv3591245 CNV loss 21293372
esv3591244 CNV loss 21293372
esv3591241 CNV loss 21293372
esv3591240 CNV loss 21293372
esv2670264 CNV deletion 23128226
esv2661385 CNV deletion 23128226
esv2425313 CNV deletion 19546169

Variation tolerance for EXOC6B Gene

Residual Variation Intolerance Score: 48.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.50; 43.83% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for EXOC6B Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for EXOC6B Gene

Disorders for EXOC6B Gene

MalaCards: The human disease database

(2) MalaCards diseases for EXOC6B Gene - From: HGMD, DISEASES, and GeneCards

Disorder Aliases PubMed IDs
renal hypodysplasia/aplasia 1
  • renal agenesis
intellectual disability
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for EXOC6B

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with EXOC6B: view

No data available for UniProtKB/Swiss-Prot and Genatlas for EXOC6B Gene

Publications for EXOC6B Gene

  1. The brain exocyst complex interacts with RalA in a GTP-dependent manner: identification of a novel mammalian Sec3 gene and a second Sec15 gene. (PMID: 11406615) Brymora A … Robinson PJ (The Journal of biological chemistry 2001) 2 3 4 60
  2. Prediction of the coding sequences of unidentified human genes. XIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 10231032) Nagase T … Ohara O (DNA research : an international journal for rapid publication of reports on genes and genomes 1999) 2 3 4 60
  3. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 60
  4. A novel multiple joint dislocation syndrome associated with a homozygous nonsense variant in the EXOC6B gene. (PMID: 26669664) Girisha KM … Kutsche K (European journal of human genetics : EJHG 2016) 3 60
  5. An organelle-specific protein landscape identifies novel diseases and molecular mechanisms. (PMID: 27173435) Boldt K … UK10K Rare Diseases Group (Nature communications 2016) 3 60

Products for EXOC6B Gene

Sources for EXOC6B Gene

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