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Aliases for EXOC6 Gene

Aliases for EXOC6 Gene

  • Exocyst Complex Component 6 2 3
  • Exocyst Complex Component Sec15A 3 4
  • SEC15-Like Protein 1 3 4
  • SEC15L1 3 4
  • SEC15L 3 4
  • SEC15-Like 1 (S. Cerevisiae) 2
  • SEC15-Like Protein 3 3
  • SEC15-Like 1 3
  • SEC15L3 3
  • EXOC6A 3
  • Sec15p 3
  • SEC15A 4
  • SEC15 3

External Ids for EXOC6 Gene

Previous HGNC Symbols for EXOC6 Gene

  • SEC15L1

Previous GeneCards Identifiers for EXOC6 Gene

  • GC10P094599
  • GC10P088221

Summaries for EXOC6 Gene

Entrez Gene Summary for EXOC6 Gene

  • The product of this gene belongs to the SEC15 family. It is highly similar to the protein encoded by Saccharomyces cerevisiae SEC15 gene. This protein is essential for vesicular traffic from the Golgi apparatus to the cell surface in yeast. It is one of the components of a multiprotein complex required for exocytosis. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]

GeneCards Summary for EXOC6 Gene

EXOC6 (Exocyst Complex Component 6) is a Protein Coding gene. Among its related pathways are Organelle biogenesis and maintenance and Actin Nucleation by ARP-WASP Complex. An important paralog of this gene is EXOC6B.

UniProtKB/Swiss-Prot for EXOC6 Gene

  • Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane. Together with RAB11A, RAB3IP, RAB8A, PARD3, PRKCI, ANXA2, CDC42 and DNMBP promotes transcytosis of PODXL to the apical membrane initiation sites (AMIS), apical surface formation and lumenogenesis (By similarity).

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for EXOC6 Gene

Genomics for EXOC6 Gene

Regulatory Elements for EXOC6 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for EXOC6 Gene

Chromosome:
10
Start:
92,834,713 bp from pter
End:
93,059,494 bp from pter
Size:
224,782 bases
Orientation:
Plus strand

Genomic View for EXOC6 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for EXOC6 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for EXOC6 Gene

Proteins for EXOC6 Gene

  • Protein details for EXOC6 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8TAG9-EXOC6_HUMAN
    Recommended name:
    Exocyst complex component 6
    Protein Accession:
    Q8TAG9
    Secondary Accessions:
    • E9PHI3
    • Q5VXH8
    • Q9NZ24

    Protein attributes for EXOC6 Gene

    Size:
    804 amino acids
    Molecular mass:
    93722 Da
    Quaternary structure:
    • The exocyst complex is composed of EXOC1, EXOC2, EXOC3, EXOC4, EXOC5, EXOC6, EXOC7 and EXOC8. Interacts with CNTRL. Interacts with RAB11A in a GTP-dependent manner (By similarity).
    SequenceCaution:
    • Sequence=AAF37262.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Alternative splice isoforms for EXOC6 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for EXOC6 Gene

Proteomics data for EXOC6 Gene at MOPED

Post-translational modifications for EXOC6 Gene

  • Ubiquitination at Lys 462
  • Modification sites at PhosphoSitePlus

Other Protein References for EXOC6 Gene

No data available for DME Specific Peptides for EXOC6 Gene

Domains & Families for EXOC6 Gene

Gene Families for EXOC6 Gene

Protein Domains for EXOC6 Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for EXOC6 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8TAG9

UniProtKB/Swiss-Prot:

EXOC6_HUMAN :
  • Belongs to the SEC15 family.
Family:
  • Belongs to the SEC15 family.
genes like me logo Genes that share domains with EXOC6: view

Function for EXOC6 Gene

Molecular function for EXOC6 Gene

UniProtKB/Swiss-Prot Function:
Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane. Together with RAB11A, RAB3IP, RAB8A, PARD3, PRKCI, ANXA2, CDC42 and DNMBP promotes transcytosis of PODXL to the apical membrane initiation sites (AMIS), apical surface formation and lumenogenesis (By similarity).
genes like me logo Genes that share phenotypes with EXOC6: view

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Animal Models , Transcription Factor Targets and HOMER Transcription for EXOC6 Gene

Localization for EXOC6 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for EXOC6 Gene COMPARTMENTS Subcellular localization image for EXOC6 gene
Compartment Confidence
cytosol 4
plasma membrane 4
endosome 2
golgi apparatus 2
nucleus 2
cytoskeleton 1

Gene Ontology (GO) - Cellular Components for EXOC6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000145 exocyst IEA --
GO:0005829 cytosol TAS --
GO:0005886 plasma membrane TAS --
genes like me logo Genes that share ontologies with EXOC6: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for EXOC6 Gene

Pathways & Interactions for EXOC6 Gene

genes like me logo Genes that share pathways with EXOC6: view

Pathways by source for EXOC6 Gene

Interacting Proteins for EXOC6 Gene

Gene Ontology (GO) - Biological Process for EXOC6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006904 vesicle docking involved in exocytosis IEA --
GO:0006996 organelle organization TAS --
GO:0015031 protein transport IEA --
GO:0030218 erythrocyte differentiation IEA --
GO:0044267 cellular protein metabolic process TAS --
genes like me logo Genes that share ontologies with EXOC6: view

No data available for SIGNOR curated interactions for EXOC6 Gene

Drugs & Compounds for EXOC6 Gene

No Compound Related Data Available

Transcripts for EXOC6 Gene

Unigene Clusters for EXOC6 Gene

Exocyst complex component 6:
Representative Sequences:

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for EXOC6

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for EXOC6 Gene

ExUns: 1a · 1b · 1c · 1d · 1e ^ 2a · 2b ^ 3a · 3b ^ 4a · 4b ^ 5a · 5b · 5c ^ 6 ^ 7 ^ 8 ^ 9a · 9b · 9c ^ 10 ^ 11 ^ 12 ^ 13 ^ 14a · 14b ^
SP1: - - - -
SP2: - - - -
SP3: -
SP4:
SP5: - - - -
SP6: - -
SP7: -
SP8: - -
SP9: - - - - - - - - - -
SP10: -

ExUns: 15 ^ 16 ^ 17 ^ 18 ^ 19 ^ 20 ^ 21 ^ 22 ^ 23a · 23b
SP1: -
SP2: -
SP3:
SP4: -
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:

Relevant External Links for EXOC6 Gene

GeneLoc Exon Structure for
EXOC6
ECgene alternative splicing isoforms for
EXOC6

Expression for EXOC6 Gene

mRNA expression in normal human tissues for EXOC6 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for EXOC6 Gene

This gene is overexpressed in Whole Blood (x5.1).

Protein differential expression in normal tissues from HIPED for EXOC6 Gene

This gene is overexpressed in Bone (14.6), Peripheral blood mononuclear cells (9.3), and Breast (6.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for EXOC6 Gene



SOURCE GeneReport for Unigene cluster for EXOC6 Gene Hs.655657

genes like me logo Genes that share expression patterns with EXOC6: view

Protein tissue co-expression partners for EXOC6 Gene

Primer Products

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for EXOC6 Gene

Orthologs for EXOC6 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for EXOC6 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia EXOC6 35
  • 94.35 (n)
  • 96.26 (a)
EXOC6 36
  • 96 (a)
OneToOne
dog
(Canis familiaris)
Mammalia EXOC6 35
  • 94.6 (n)
  • 97.13 (a)
EXOC6 36
  • 97 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Exoc6 35
  • 88.75 (n)
  • 93.4 (a)
Exoc6 16
Exoc6 36
  • 93 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia EXOC6 35
  • 99.63 (n)
  • 99.75 (a)
EXOC6 36
  • 95 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Exoc6 35
  • 87.81 (n)
  • 93.03 (a)
oppossum
(Monodelphis domestica)
Mammalia EXOC6 36
  • 92 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia EXOC6 36
  • 86 (a)
OneToOne
chicken
(Gallus gallus)
Aves EXOC6 35
  • 83.07 (n)
  • 89.55 (a)
EXOC6 36
  • 86 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia EXOC6 36
  • 83 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia exoc6 35
  • 77.56 (n)
  • 84.29 (a)
zebrafish
(Danio rerio)
Actinopterygii Dr.13869 35
exoc6 35
  • 73.29 (n)
  • 83.06 (a)
exoc6 36
  • 84 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta sec15 36
  • 42 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea sec-15 36
  • 37 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes SEC15 36
  • 16 (a)
OneToMany
SEC15 38
sea squirt
(Ciona savignyi)
Ascidiacea CSA.3590 36
  • 51 (a)
OneToMany
Species with no ortholog for EXOC6:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for EXOC6 Gene

ENSEMBL:
Gene Tree for EXOC6 (if available)
TreeFam:
Gene Tree for EXOC6 (if available)

Paralogs for EXOC6 Gene

Paralogs for EXOC6 Gene

(3) SIMAP similar genes for EXOC6 Gene using alignment to 6 proteins:

genes like me logo Genes that share paralogs with EXOC6: view

Variants for EXOC6 Gene

Sequence variations from dbSNP and Humsavar for EXOC6 Gene

SNP ID Clin Chr 10 pos Sequence Context AA Info Type MAF
rs726273 -- 92,962,910(-) TTATA(G/T)AGTTT intron-variant
rs726274 -- 92,963,076(-) TCTGC(C/T)TTCTG intron-variant
rs835234 -- 92,993,611(+) ACTTT(C/G)AAAAC intron-variant
rs835235 -- 92,993,788(+) CTGAG(A/G)GTTGG intron-variant
rs835236 -- 92,994,394(+) AAATA(C/T)AAGAA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for EXOC6 Gene

Variant ID Type Subtype PubMed ID
esv2739618 CNV Deletion 23290073
nsv895898 CNV Loss 21882294
nsv515937 CNV Gain 19592680
nsv518124 CNV Loss 19592680
nsv522103 CNV Gain 19592680
nsv467434 CNV Loss 19166990
nsv467435 CNV Loss 19166990
esv2661106 CNV Deletion 23128226
nsv24948 CNV Insertion 16902084
esv1627699 CNV Insertion 17803354
esv2336668 CNV Deletion 18987734
nsv7493 CNV Loss 18451855
esv997943 CNV Insertion 20482838
nsv895899 CNV Loss 21882294

Variation tolerance for EXOC6 Gene

Residual Variation Intolerance Score: 73.72% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.64; 72.68% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for EXOC6 Gene

HapMap Linkage Disequilibrium report
EXOC6

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for EXOC6 Gene

Disorders for EXOC6 Gene

Relevant External Links for EXOC6

Genetic Association Database (GAD)
EXOC6
Human Genome Epidemiology (HuGE) Navigator
EXOC6
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
EXOC6
genes like me logo Genes that share disorders with EXOC6: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for EXOC6 Gene

Publications for EXOC6 Gene

  1. Normalization and subtraction: two approaches to facilitate gene discovery. (PMID: 8889548) Bonaldo M.F. … Soares M.B. (Genome Res. 1996) 2 67
  2. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 67
  3. Temporal proteomics of NGF-TrkA signaling identifies an inhibitory role for the E3 ligase Cbl-b in neuroblastoma cell differentiation. (PMID: 25921289) Emdal K.B. … Olsen J.V. (Sci Signal 2015) 67
  4. Panorama of ancient metazoan macromolecular complexes. (PMID: 26344197) Wan C. … Emili A. (Nature 2015) 67
  5. NDR2-mediated Rabin8 phosphorylation is crucial for ciliogenesis by switching binding specificity from phosphatidylserine to Sec15. (PMID: 23435566) Chiba S. … Mizuno K. (EMBO J. 2013) 67

Products for EXOC6 Gene

Sources for EXOC6 Gene

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