Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 



EXOC5 Gene

protein-coding   GIFtS: 56
GCID: GC14M057669

Exocyst Complex Component 5

(Previous names: SEC10 (S. cerevisiae)-like 1, SEC10-like 1 (S. cerevisiae))
(Previous symbol: SEC10L1)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

TryGeneCards Plus

Aliases
Exocyst Complex Component 51 2     HSEC102
SEC10L11 2 3 5     PRO19122
Exocyst Complex Component Sec102 3     SEC10P2
SEC102 3     SEC10-Like 12
SEC10 (S. Cerevisiae)-Like 11     hSec103
SEC10-Like 1 (S. Cerevisiae)1     

External Ids:    HGNC: 106961   Entrez Gene: 106402   Ensembl: ENSG000000703677   OMIM: 6044695   UniProtKB: O004713   

Export aliases for EXOC5 gene to outside databases

Previous GC identifers: GC14M056740 GC14M037833


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

TryGeneCards Plus

Entrez Gene summary for EXOC5 Gene:
The protein encoded by this gene is a component of the exocyst complex, a multiple protein complex essential for
targeting exocytic vesicles to specific docking sites on the plasma membrane. Though best characterized in yeast,
the component proteins and functions of exocyst complex have been demonstrated to be highly conserved in higher
eukaryotes. At least eight components of the exocyst complex, including this protein, are found to interact with
the actin cytoskeletal remodeling and vesicle transport machinery. The complex is also essential for the
biogenesis of epithelial cell surface polarity. (provided by RefSeq, Jul 2008)

GeneCards Summary for EXOC5 Gene:
EXOC5 (exocyst complex component 5) is a protein-coding gene. Diseases associated with EXOC5 include polycystic kidney disease, and kidney disease. GO annotations related to this gene include protein N-terminus binding.

UniProtKB/Swiss-Prot: EXOC5_HUMAN, O00471
Function: Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the
plasma membrane

Gene Wiki entry for EXOC5 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

TryGeneCards Plus
Regulatory elements:
   Regulatory transcription factor binding sites in the EXOC5 gene promoter:
         Pax-5   AML1a   LUN-1   Meis-1b   POU2F1   POU2F1a   Meis-1a   Meis-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidEXOC5 promoter sequence
   Search Chromatin IP Primers for EXOC5

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat EXOC5


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 14q22.3   Ensembl cytogenetic band:  14q22.3   HGNC cytogenetic band: 14q22.3

EXOC5 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
EXOC5 gene location

GeneLoc information about chromosome 14         GeneLoc Exon Structure

GeneLoc location for GC14M057669:  view genomic region     (about GC identifiers)

Start:
57,669,194 bp from pter      End:
57,735,726 bp from pter
Size:
66,533 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

TryGeneCards Plus

UniProtKB/Swiss-Prot: EXOC5_HUMAN, O00471 (See protein sequence)
Recommended Name: Exocyst complex component 5  
Size: 708 amino acids; 81853 Da
Subunit: The exocyst complex is composed of EXOC1, EXOC2, EXOC3, EXOC4, EXOC5, EXOC6, EXOC7 and EXOC8. Interacts
with EXOC3L1 (By similarity)
Secondary accessions: B2R6C5

Explore the universe of human proteins at neXtProt for EXOC5: NX_O00471

Explore proteomics data for EXOC5 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See EXOC5 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_006535.1  
    ENSEMBL proteins: 
     ENSP00000389934   ENSP00000342100   ENSP00000451082   ENSP00000452084  
    Reactome Protein details: O00471

    EXOC5 Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    OriGene Protein Over-expression Lysate for EXOC5
    OriGene Custom MassSpec
    OriGene Custom Protein Services for EXOC5
    GenScript Custom Purified and Recombinant Proteins Services for EXOC5
    Novus Biologicals EXOC5 Protein
    Novus Biologicals EXOC5 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for EXOC5

    EXOC5 Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for EXOC5
    Novus Biologicals EXOC5 Antibodies
    Abcam antibodies for EXOC5
    Cloud-Clone Corp. Antibodies for EXOC5
    ThermoFisher Antibody for EXOC5
    LSBio Antibodies in human, mouse, rat for EXOC5

    EXOC5 Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for EXOC5
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for EXOC5
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for EXOC5
    Cloud-Clone Corp. CLIAs for EXOC5


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    TryGeneCards Plus
    1 InterPro protein domain:
     IPR009976 Sec10-like

    Graphical View of Domain Structure for InterPro Entry O00471

    ProtoNet protein and cluster: O00471

    1 Blocks protein domain: IPB009976 Exocyst complex component Sec10

    UniProtKB/Swiss-Prot: EXOC5_HUMAN, O00471
    Similarity: Belongs to the SEC10 family


    EXOC5 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: EXOC5_HUMAN, O00471
    Function: Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the
    plasma membrane

         Gene Ontology (GO): 1 molecular function term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0047485protein N-terminus binding IEA--
         
    EXOC5 for ontologies           About GeneDecksing


    Phenotypes:
         2 GenomeRNAi human phenotypes for EXOC5:
     G0/1 arrest  Increased S DNA content 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for EXOC5
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for EXOC5

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for EXOC5
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for EXOC5

    miRNA
    Products:
        
    miRTarBase miRNAs that target EXOC5:
    hsa-mir-21-5p (MIRT031031), hsa-mir-32-5p (MIRT028361), hsa-mir-132-3p (MIRT021840), hsa-mir-590-3p (MIRT016216), hsa-mir-103a-3p (MIRT027217), hsa-mir-484 (MIRT041666), hsa-mir-877-3p (MIRT036847)

    Block miRNA regulation of human, mouse, rat EXOC5 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate EXOC5 (see all 125):
    hsa-miR-548j hsa-miR-361-5p hsa-miR-15a hsa-miR-200a hsa-miR-374a hsa-miR-3921 hsa-miR-629* hsa-miR-29a*
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for EXOC5
    Predesigned siRNA for gene silencing in human, mouse, rat EXOC5

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for EXOC5

    Clone
    Products:
         
    OriGene clones in human, mouse for EXOC5 (see all 7)
    OriGene ORF clones in mouse, rat for EXOC5
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: EXOC5 (NM_006544)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for EXOC5
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat EXOC5

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for EXOC5
    Browse ESI BIO Cell Lines and PureStem Progenitors for EXOC5 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for EXOC5


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Subcellular locations from UniProtKB/Swiss-Prot
    EXOC5_HUMAN, O00471: Cytoplasm
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol4
    mitochondrion2
    nucleus2
    plasma membrane2
    endosome1
    golgi apparatus1

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm TAS9119050
    GO:0005829cytosol TAS--
    GO:0016020membrane ----

    EXOC5 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
    About This Section

    TryGeneCards Plus

    SuperPaths for EXOC5 About    
    See pathways by source

    SuperPathContained pathways About
    1Clathrin derived vesicle budding
    Membrane Trafficking0.32
    Translocation of GLUT4 to the Plasma Membrane0.32
    2Peptide hormone metabolism
    Peptide hormone metabolism0.30
    Insulin Processing0.30
    3Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein
    Metabolism of proteins0.30
    4Insulin Pathway
    Insulin Pathway
    5Arf6 trafficking events
    Arf6 trafficking events

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    2 Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for EXOC5
        Epithelial Tight Junctions
    CDC42 Pathway

    2 BioSystems Pathways for EXOC5
        Arf6 trafficking events
    Insulin Pathway

    2 Reactome Pathways for EXOC5
        Translocation of GLUT4 to the plasma membrane
    Insulin processing



    EXOC5 for pathways           About GeneDecksing

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for EXOC5
    Interactions:

        Search GeneGlobe Interaction Network for EXOC5

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for EXOC5 (O004712, 3 ENSP000003899344) via UniProtKB, MINT, STRING, and/or I2D (see all 952)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    COPG2Q9UBF22, 3MINT-7945693 MINT-7947479 I2D: score=4 
    HSP90AA1P079002, 3MINT-7945693 MINT-7947479 I2D: score=4 
    LMNAP025452, 3MINT-7945693 MINT-7947479 I2D: score=4 
    RAD50Q928782, 3MINT-7945693 MINT-7947479 I2D: score=4 
    EEF1A1P681042, 3MINT-7945693 MINT-7947479 I2D: score=3 
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006887exocytosis IEA--
    GO:0006892post-Golgi vesicle-mediated transport TAS9119050
    GO:0015031protein transport IEA--
    GO:0016192vesicle-mediated transport ----
    GO:0044267cellular protein metabolic process TAS--

    EXOC5 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
    About This Section

    TryGeneCards Plus
    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for EXOC5



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
    About This Section

    TryGeneCards Plus

    REFSEQ mRNAs for EXOC5 gene: 
    NM_006544.3  

    10 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000413566(uc001xcs.3 uc001xct.3 uc010trg.2 uc010trh.2)
    ENST00000554011 ENST00000340918 ENST00000555148 ENST00000556629 ENST00000554934
    ENST00000554598 ENST00000556911 ENST00000555749 ENST00000556318
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat EXOC5 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate EXOC5 (see all 125):
    hsa-miR-548j hsa-miR-361-5p hsa-miR-15a hsa-miR-200a hsa-miR-374a hsa-miR-3921 hsa-miR-629* hsa-miR-29a*
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for EXOC5
    Predesigned siRNA for gene silencing in human, mouse, rat EXOC5
    Clone
    Products:
         
    OriGene clones in human, mouse for EXOC5 (see all 7)
    OriGene ORF clones in mouse, rat for EXOC5
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: EXOC5 (NM_006544)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for EXOC5
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat EXOC5
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for EXOC5
    OriGene qSTAR qPCR primer pairs in human, mouse for EXOC5
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat EXOC5
      QuantiTect SYBR Green Assays in human, mouse, rat EXOC5
      QuantiFast Probe-based Assays in human, mouse, rat EXOC5

    Selected AceView cDNA sequences (see all 349):

    BU631949 AA905177 AL118623 BU158424 AA805159 AL833745 AI810258 AW571657 
    CA419226 AI697326 AI122945 AI240222 AA629214 BM856661 U85946 CK904188 
    AI401495 NM_006544 CB164610 BU675055 R31398 AI221473 CA450300 BP341015 

    GeneLoc Exon Structure

    3 Alternative Splicing Database (ASD) splice patterns (SP) for EXOC5    About this scheme

    ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18
    SP1:                                      -                                                                                       
    SP2:                                -     -                                                                                       
    SP3:                                                                                                                              


    ECgene alternative splicing isoforms for EXOC5

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TryGeneCards Plus

    EXOC5 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    EXOC5 Expression
    About this image

    EXOC5 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    EXOC5 Protein Expression

    UniProtKB/Swiss-Prot: EXOC5_HUMAN, O00471
    Tissue specificity: Ubiquitous

        Custom PCR Arrays for EXOC5
    Primer
    Products:
    OriGene qPCR primer pairs and template standards for EXOC5
    OriGene qSTAR qPCR primer pairs in human, mouse for EXOC5
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat EXOC5
    QuantiTect SYBR Green Assays in human, mouse, rat EXOC5
    QuantiFast Probe-based Assays in human, mouse, rat EXOC5
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for EXOC5

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    TryGeneCards Plus

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for EXOC5 gene from Selected species (see all 24)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Exoc51 , 5 exocyst complex component 51, 5 92.23(n)1
    98.45(a)1
      14 (25.36 cM)5
    1055041  NM_207214.31  NP_997097.11 
     490121465 
    chicken
    (Gallus gallus)
    Aves EXOC51 exocyst complex component 5 84.96(n)
    95.62(a)
      423549  NM_001012589.1  NP_001012607.1 
    lizard
    (Anolis carolinensis)
    Reptilia EXOC56
    exocyst complex component 5
    86(a)
    1 ↔ 1
    GL343325.1(959686-993619)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.66192 Xenopus laevis transcribed sequence with moderate similarity more 79.74(n)    BU914694.1 
    zebrafish
    (Danio rerio)
    Actinopterygii exoc51 exocyst complex component 5 72.88(n)
    83.33(a)
      559010  NM_001113796.1  NP_001107268.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta sec101 sec10 51.87(n)
    43.96(a)
      42863  NM_142961.4  NP_651218.1 
    worm
    (Caenorhabditis elegans)
    Secernentea sec-101 sec-10 50.36(n)
    37.46(a)
      177562  NM_068882.4  NP_501283.1 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes SEC10(YLR166C)4
    SEC101
    Essential 100kDa subunit of the exocyst complex (Sec3p, more4
    SEC101
    44.89(n)1
    25.1(a)1
      12(498044-495429)4
    8508631, 4  NP_013267.11, 4 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons SEC101 SEC10 42.12(n)
    27.44(a)
      831112  NM_121275.4  NP_568270.3 
    rice
    (Oryza sativa)
    Liliopsida Os12g02381001 Os12g0238100 43.01(n)
    28.41(a)
      4351857  NM_001073001.1  NP_001066469.1 


    ENSEMBL Gene Tree for EXOC5 (if available)
    TreeFam Gene Tree for EXOC5 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

    TryGeneCards Plus
    Paralogs for EXOC5 gene
    1 SIMAP similar gene for EXOC5 using alignment to 5 protein entries:     EXOC5_HUMAN (see all proteins):
    DKFZp666H126

    EXOC5 for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for EXOC5
    PGOHUM00000245929


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

    TryGeneCards Plus

    Selected SNPs for EXOC5 (see all 1267)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 14 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1397665421,2
    --57668744(+) AATGAA/TCATCA 1 -- ds50010--------
    rs1444889951,2
    --57668761(+) ATGGGA/GCAAAT 1 -- ds50010--------
    rs101350641,2
    C,F,A,H--57668859(+) TTACGT/GGGAAA 1 -- ds500121Minor allele frequency- G:0.43NS EA NA WA CSA 2053
    rs1466146201,2
    C--57668889(+) GTGTTC/TTACAA 1 -- ds50010--------
    rs770666621,2
    C,F--57668932(+) GAGTCA/TAAAAA 1 -- ds50011Minor allele frequency- T:0.09EA 120
    rs1483006361,2
    C--57668977(+) TGAGA-/CTAG  
            
    CTAGA
    1 -- ds50010--------
    rs101374561,2
    C,F,A,H--57669003(+) AGCAAT/CACATG 1 -- ds500117Minor allele frequency- C:0.35NS EA WA NA CSA 1171
    rs1140742951,2
    C,F--57669369(+) GTTAAT/CCATGG 1 -- ut311Minor allele frequency- C:0.03WA 118
    rs118510151,2
    C,F,H--57669533(+) TTCATA/GGATGC 1 -- ut3114Minor allele frequency- G:0.25NS EA NA WA 1982
    rs1423823581,2
    --57669649(+) AACTTA/GAGAGA 1 -- ut310--------

    HapMap Linkage Disequilibrium report for EXOC5 (57669194 - 57735726 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for EXOC5:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv901984CNV Loss21882294

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing EXOC5
    DNA2.0 Custom Variant and Variant Library Synthesis for EXOC5

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TryGeneCards Plus
    OMIM gene information: 604469    OMIM disorders: --

    8 diseases for EXOC5:    
    About MalaCards
    polycystic kidney disease    kidney disease    intrahepatic cholangiocarcinoma    cholangiocarcinoma
    ataxia    rheumatoid arthritis    arthritis    malaria

    1 disease from the University of Copenhagen DISEASES database for EXOC5:
    Polycystic kidney disease

    EXOC5 for disorders           About GeneDecksing

    Genetic Association Database (GAD): EXOC5
    Human Genome Epidemiology (HuGE) Navigator: EXOC5 (2 documents)

    Export disorders for EXOC5 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    TryGeneCards Plus

    PubMed articles for EXOC5 gene, integrated from 10 sources (see all 30):
    (articles sorted by number of sources associating them with EXOC5)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Identification and characterization of homologues of the exocyst component Sec10p. (PubMed id 9119050)1, 2, 3, 9 Guo W.... Novick P. (FEBS Lett. 1997)
    2. Association between single-nucleotide polymorphisms in the SEC8L1 gene, which encodes a subunit of the exocyst complex, and rheumatoid arthritis in a Japanese population. (PubMed id 15880602)1, 4 Hamada D....Itakura M. (Arthritis Rheum. 2005)
    3. Interlaboratory reproducibility of large-scale human protein-complex analysis by standardized AP-MS. (PubMed id 23455922)1 Varjosalo M....Superti-Furga G. (Nat. Methods 2013)
    4. Characterization of the EGFR interactome reveals associated protein complex networks and intracellular receptor dynamics. (PubMed id 23956138)1 Foerster S....Ritter C.A. (Proteomics 2013)
    5. A meta-analysis of two genome-wide association studies to identify novel loci for maximum number of alcoholic drinks. (PubMed id 23743675)1 Kapoor M....Goate A. (Hum. Genet. 2013)
    6. The proteomic analysis of endogenous FAT10 substrates identifies p62/SQSTM1 as a substrate of FAT10ylation. (PubMed id 22797925)1 Aichem A....Groettrup M. (J. Cell. Sci. 2012)
    7. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (Cell 2012)
    8. Methods for quantification of in vivo changes in protein ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)1 Udeshi N.D....Carr S.A. (amp 2012)
    9. N-terminal acetylome analyses and functional insights of the N- terminal acetyltransferase NatB. (PubMed id 22814378)2 Van Damme P....Aldabe R. (Proc. Natl. Acad. Sci. U.S.A. 2012)
    10. Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (BMC Syst. Biol. 2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

    TryGeneCards Plus
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

    TryGeneCards Plus
    Entrez Gene: 10640 HGNC: 10696 AceView: SEC10L1 Ensembl:ENSG00000070367 euGenes: HUgn10640
    ECgene: EXOC5 H-InvDB: EXOC5

    (According to HUGE)
    About This Section

    TryGeneCards Plus
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

    TryGeneCards Plus
    NameDescription
    PharmGKB entry for EXOC5 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus
    Patent Information for EXOC5 gene:
    Search GeneIP for patents involving EXOC5

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

    TryGeneCards Plus

     
     EMD Millipore genomic analysis products

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Enzyme Activity Assays/Reagents  
     Browse ELISpot/FluoroSpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Luminex Assays  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Recombinant/Natural Proteins   Browse Stem Cell Products  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     Browse OriGene Antibodies   OriGene RNAi products in human, mouse, rat for EXOC5  
     OriGene qPCR primer pairs and template standards for EXOC5   OriGene Protein Over-expression Lysate for EXOC5  
     OriGene Custom Mass Spec   OriGene clones in human, mouse for EXOC5  
     OriGene qSTAR qPCR primer pairs in human, mouse for EXOC5   Browse OriGene full length recombinant human proteins expressed in human HEK293 cells  
     OriGene ORF clones in mouse, rat for EXOC5   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for EXOC5   OriGene Custom Protein Services for EXOC5  

     
     
     Block miRNA regulation of human, mouse, rat EXOC5 using miScript Target Protectors SeqTarget long-range PCR primers for resequencing EXOC5
     DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat EXOC5 Predesigned siRNA for gene silencing in human, mouse, rat EXOC5
     QuantiFast Probe-based Assays in human, mouse, rat EXOC5 QuantiTect SYBR Green Assays in human, mouse, rat EXOC5
     Custom PCR Arrays for EXOC5 Search Chromatin IP Primers for EXOC5
     Pre-validated RT2 qPCR Primer Assay in human, mouse, rat EXOC5  Search GeneGlobe Interaction Network for EXOC5
     Regulatory tfbs in EXOC5 promoter
     GenScript Custom Purified and Recombinant Proteins Services for EXOC5 GenScript cDNA clones with any tag delivered in your preferred vector for EXOC5
     GenScript Custom Assay Services for EXOC5 GenScript Custom overexpressing Cell Line Services for EXOC5
     CloneReady with Over 120,000 Genes  Gene Synthesis: Any Gene in Any Vector
     Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
     Plasmid Preparation Custom Peptide Services
     Search for Antibodies & Assays

     Search Tocris compounds for EXOC5
     Browse Sino Biological Proteins
     Browse Sino Biological Cell Lysates
     Browse Sino Biological cDNA Clones
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

     Novus Tissue Slides
     EXOC5 antibodies
     EXOC5 proteins
     EXOC5 lysates
     Antibodies for EXOC5
     See all of Abcam's Antibodies, Kits and Proteins for EXOC5
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins
     Proteins for EXOC5
     Antibodies for EXOC5
     ELISAs for EXOC5
     CLIAs for EXOC5



     Browse ESI BIO Cell Lines and PureStem Progenitors for EXOC5
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for EXOC5
     Browse SwitchGear 3'UTR luciferase reporter plasmids for EXOC5
     SwitchGear Promoter luciferase reporter plasmids for EXOC5
     ThermoFisher Antibody for EXOC5
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat EXOC5
     inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for EXOC5
     inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for EXOC5
     LSBio Antibodies in human, mouse, rat for EXOC5
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
     Browse compounds at ApexBio
           
    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014

    View Random Gene

    Category
    (GIFtS: )
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      EXOC5 gene at Home site.
    Version: 3.12.142 28 July 2014
    hostname: 356980-web2.xennexinc.com index build: 126 solr: 1.4