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Aliases for EXOC5 Gene

Aliases for EXOC5 Gene

  • Exocyst Complex Component 5 2 3 5
  • Exocyst Complex Component Sec10 3 4
  • SEC10L1 3 4
  • HSEC10 3 4
  • SEC10 3 4
  • SEC10 (S. Cerevisiae)-Like 1 2
  • SEC10-Like 1 (S. Cerevisiae) 2
  • SEC10-Like 1 3
  • PRO1912 3
  • SEC10P 3

External Ids for EXOC5 Gene

Previous HGNC Symbols for EXOC5 Gene

  • SEC10L1

Previous GeneCards Identifiers for EXOC5 Gene

  • GC14M056740
  • GC14M057669
  • GC14M037833

Summaries for EXOC5 Gene

Entrez Gene Summary for EXOC5 Gene

  • The protein encoded by this gene is a component of the exocyst complex, a multiple protein complex essential for targeting exocytic vesicles to specific docking sites on the plasma membrane. Though best characterized in yeast, the component proteins and functions of exocyst complex have been demonstrated to be highly conserved in higher eukaryotes. At least eight components of the exocyst complex, including this protein, are found to interact with the actin cytoskeletal remodeling and vesicle transport machinery. The complex is also essential for the biogenesis of epithelial cell surface polarity. [provided by RefSeq, Jul 2008]

GeneCards Summary for EXOC5 Gene

EXOC5 (Exocyst Complex Component 5) is a Protein Coding gene. Among its related pathways are Cargo trafficking to the periciliary membrane and Peptide hormone metabolism. GO annotations related to this gene include protein N-terminus binding and Ral GTPase binding.

UniProtKB/Swiss-Prot for EXOC5 Gene

  • Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane.

Gene Wiki entry for EXOC5 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for EXOC5 Gene

Genomics for EXOC5 Gene

Regulatory Elements for EXOC5 Gene

Enhancers for EXOC5 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
- Elite enhancer/Elite enhancer-gene association

Enhancers around EXOC5 on UCSC Golden Path with GeneCards custom track

Promoters for EXOC5 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around EXOC5 on UCSC Golden Path with GeneCards custom track

Genomic Location for EXOC5 Gene

Chromosome:
14
Start:
57,200,507 bp from pter
End:
57,269,008 bp from pter
Size:
68,502 bases
Orientation:
Minus strand

Genomic View for EXOC5 Gene

Genes around EXOC5 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
EXOC5 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for EXOC5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for EXOC5 Gene

Proteins for EXOC5 Gene

  • Protein details for EXOC5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O00471-EXOC5_HUMAN
    Recommended name:
    Exocyst complex component 5
    Protein Accession:
    O00471
    Secondary Accessions:
    • B2R6C5

    Protein attributes for EXOC5 Gene

    Size:
    708 amino acids
    Molecular mass:
    81853 Da
    Quaternary structure:
    • The exocyst complex is composed of EXOC1, EXOC2, EXOC3, EXOC4, EXOC5, EXOC6, EXOC7 and EXOC8. Interacts with EXOC3L1 (By similarity).

neXtProt entry for EXOC5 Gene

Post-translational modifications for EXOC5 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for EXOC5 Gene

No data available for DME Specific Peptides for EXOC5 Gene

Domains & Families for EXOC5 Gene

Gene Families for EXOC5 Gene

Protein Domains for EXOC5 Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for EXOC5 Gene

Graphical View of Domain Structure for InterPro Entry

O00471

UniProtKB/Swiss-Prot:

EXOC5_HUMAN :
  • Belongs to the SEC10 family.
Family:
  • Belongs to the SEC10 family.
genes like me logo Genes that share domains with EXOC5: view

Function for EXOC5 Gene

Molecular function for EXOC5 Gene

UniProtKB/Swiss-Prot Function:
Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane.

Gene Ontology (GO) - Molecular Function for EXOC5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0017160 Ral GTPase binding IPI 24056301
GO:0047485 protein N-terminus binding IEA --
genes like me logo Genes that share ontologies with EXOC5: view
genes like me logo Genes that share phenotypes with EXOC5: view

Animal Model Products

  • Taconic Biosciences Mouse Models for EXOC5

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for EXOC5

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for EXOC5 Gene

Localization for EXOC5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for EXOC5 Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for EXOC5 Gene COMPARTMENTS Subcellular localization image for EXOC5 gene
Compartment Confidence
cytosol 5
mitochondrion 2
nucleus 2
plasma membrane 2
endosome 1
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for EXOC5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm TAS 9119050
GO:0005829 cytosol IEA,TAS --
genes like me logo Genes that share ontologies with EXOC5: view

Pathways & Interactions for EXOC5 Gene

genes like me logo Genes that share pathways with EXOC5: view

Pathways by source for EXOC5 Gene

Gene Ontology (GO) - Biological Process for EXOC5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006887 exocytosis IEA --
GO:0006892 post-Golgi vesicle-mediated transport TAS 9119050
GO:0015031 protein transport IEA --
GO:0048278 vesicle docking IEA --
genes like me logo Genes that share ontologies with EXOC5: view

No data available for SIGNOR curated interactions for EXOC5 Gene

Drugs & Compounds for EXOC5 Gene

No Compound Related Data Available

Transcripts for EXOC5 Gene

Unigene Clusters for EXOC5 Gene

Exocyst complex component 5:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for EXOC5

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for EXOC5 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18
SP1: -
SP2: - -
SP3:

Relevant External Links for EXOC5 Gene

GeneLoc Exon Structure for
EXOC5
ECgene alternative splicing isoforms for
EXOC5

Expression for EXOC5 Gene

mRNA expression in normal human tissues for EXOC5 Gene

Protein differential expression in normal tissues from HIPED for EXOC5 Gene

This gene is overexpressed in Bone (48.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for EXOC5 Gene



Protein tissue co-expression partners for EXOC5 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of EXOC5 Gene:

EXOC5

SOURCE GeneReport for Unigene cluster for EXOC5 Gene:

Hs.743987

mRNA Expression by UniProt/SwissProt for EXOC5 Gene:

O00471-EXOC5_HUMAN
Tissue specificity: Ubiquitous.
genes like me logo Genes that share expression patterns with EXOC5: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for EXOC5 Gene

Orthologs for EXOC5 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for EXOC5 Gene

Organism Taxonomy Gene Similarity Type Details
rat
(Rattus norvegicus)
Mammalia Exoc5 34
  • 91.53 (n)
  • 98.16 (a)
mouse
(Mus musculus)
Mammalia Exoc5 16
Exoc5 35
  • 98 (a)
OneToOne
Exoc5 34
  • 92.23 (n)
  • 98.45 (a)
cow
(Bos Taurus)
Mammalia EXOC5 35
  • 98 (a)
OneToOne
EXOC5 34
  • 94.92 (n)
  • 98.02 (a)
dog
(Canis familiaris)
Mammalia EXOC5 35
  • 99 (a)
OneToOne
EXOC5 34
  • 95.39 (n)
  • 99.44 (a)
chimpanzee
(Pan troglodytes)
Mammalia EXOC5 35
  • 100 (a)
OneToOne
EXOC5 34
  • 99.2 (n)
  • 99.44 (a)
platypus
(Ornithorhynchus anatinus)
Mammalia EXOC5 35
  • 97 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia EXOC5 35
  • 95 (a)
OneToOne
chicken
(Gallus gallus)
Aves EXOC5 35
  • 78 (a)
OneToOne
EXOC5 34
  • 84.96 (n)
  • 95.62 (a)
lizard
(Anolis carolinensis)
Reptilia EXOC5 35
  • 86 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia exoc5 34
  • 79.43 (n)
  • 90.68 (a)
Str.1996 34
African clawed frog
(Xenopus laevis)
Amphibia Xl.6619 34
zebrafish
(Danio rerio)
Actinopterygii exoc5 35
  • 83 (a)
OneToOne
exoc5 34
  • 72.88 (n)
  • 83.33 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP004147 34
  • 51.04 (n)
  • 43.99 (a)
fruit fly
(Drosophila melanogaster)
Insecta sec10 34
  • 51.87 (n)
  • 43.96 (a)
sec10 35
  • 39 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea sec-10 34
  • 50.36 (n)
  • 37.46 (a)
sec-10 35
  • 34 (a)
OneToOne
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AGL130C 34
  • 42.15 (n)
  • 23.87 (a)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0D18260g 34
  • 42.49 (n)
  • 25.8 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes SEC10 34
  • 44.89 (n)
  • 25.1 (a)
SEC10 35
  • 17 (a)
OneToOne
SEC10 37
thale cress
(Arabidopsis thaliana)
eudicotyledons SEC10 34
  • 42.12 (n)
  • 27.44 (a)
rice
(Oryza sativa)
Liliopsida Os12g0238100 34
  • 43.01 (n)
  • 28.41 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.5751 34
bread mold
(Neurospora crassa)
Ascomycetes NCU09313 34
  • 38.74 (n)
  • 26.15 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes sec10 34
  • 39.38 (n)
  • 20.74 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.2378 35
  • 48 (a)
OneToOne
Species where no ortholog for EXOC5 was found in the sources mined by GeneCards:
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for EXOC5 Gene

ENSEMBL:
Gene Tree for EXOC5 (if available)
TreeFam:
Gene Tree for EXOC5 (if available)

Paralogs for EXOC5 Gene

(1) SIMAP similar genes for EXOC5 Gene using alignment to 5 proteins:

Pseudogenes.org Pseudogenes for EXOC5 Gene

genes like me logo Genes that share paralogs with EXOC5: view

No data available for Paralogs for EXOC5 Gene

Variants for EXOC5 Gene

Sequence variations from dbSNP and Humsavar for EXOC5 Gene

SNP ID Clin Chr 14 pos Sequence Context AA Info Type
rs35132458 - 57,247,710(+) AAAGG(C/G/T)TCCTA reference, synonymous-codon, missense
rs1555788 -- 57,218,454(+) GTTTT(A/C)AGAAT intron-variant
rs7141360 -- 57,225,016(+) gagat(C/T)gtgcc intron-variant
rs7141911 -- 57,206,153(+) GCGGT(A/G)TTGTG utr-variant-3-prime
rs7142694 -- 57,228,270(+) ctagt(A/C)caacc intron-variant

Structural Variations from Database of Genomic Variants (DGV) for EXOC5 Gene

Variant ID Type Subtype PubMed ID
nsv1046422 CNV gain 25217958
nsv1138303 CNV deletion 24896259
nsv977472 CNV duplication 23825009

Variation tolerance for EXOC5 Gene

Residual Variation Intolerance Score: 57.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.69; 46.16% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for EXOC5 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
EXOC5

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for EXOC5 Gene

Disorders for EXOC5 Gene

Relevant External Links for EXOC5

Genetic Association Database (GAD)
EXOC5
Human Genome Epidemiology (HuGE) Navigator
EXOC5
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
EXOC5

No disorders were found for EXOC5 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for EXOC5 Gene

Publications for EXOC5 Gene

  1. Identification and characterization of homologues of the exocyst component Sec10p. (PMID: 9119050) Guo W. … Novick P. (FEBS Lett. 1997) 2 3 4 22 65
  2. Association between single-nucleotide polymorphisms in the SEC8L1 gene, which encodes a subunit of the exocyst complex, and rheumatoid arthritis in a Japanese population. (PMID: 15880602) Hamada D. … Itakura M. (Arthritis Rheum. 2005) 3 46 65
  3. Temporal proteomics of NGF-TrkA signaling identifies an inhibitory role for the E3 ligase Cbl-b in neuroblastoma cell differentiation. (PMID: 25921289) Emdal K.B. … Olsen J.V. (Sci Signal 2015) 3 65
  4. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3 65
  5. Panorama of ancient metazoan macromolecular complexes. (PMID: 26344197) Wan C. … Emili A. (Nature 2015) 3 65

Products for EXOC5 Gene

Sources for EXOC5 Gene

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