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Aliases for EXOC4 Gene

Aliases for EXOC4 Gene

  • Exocyst Complex Component 4 2 3 5
  • Exocyst Complex Component Sec8 3 4
  • SEC8L1 3 4
  • SEC8 3 4
  • SEC8-Like 1 (S. Cerevisiae) 2
  • SEC8-Like 1 3
  • KIAA1699 4
  • Sec8p 3

External Ids for EXOC4 Gene

Previous HGNC Symbols for EXOC4 Gene

  • SEC8L1

Previous GeneCards Identifiers for EXOC4 Gene

  • GC07P132396
  • GC07P132588
  • GC07P132937
  • GC07P127253

Summaries for EXOC4 Gene

Entrez Gene Summary for EXOC4 Gene

  • The protein encoded by this gene is a component of the exocyst complex, a multiple protein complex essential for targeting exocytic vesicles to specific docking sites on the plasma membrane. Though best characterized in yeast, the component proteins and functions of exocyst complex have been demonstrated to be highly conserved in higher eukaryotes. At least eight components of the exocyst complex, including this protein, are found to interact with the actin cytoskeletal remodeling and vesicle transport machinery. The complex is also essential for the biogenesis of epithelial cell surface polarity. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008]

GeneCards Summary for EXOC4 Gene

EXOC4 (Exocyst Complex Component 4) is a Protein Coding gene. Among its related pathways are Organelle biogenesis and maintenance and Vesicle-mediated transport. GO annotations related to this gene include PDZ domain binding and Ral GTPase binding.

UniProtKB/Swiss-Prot for EXOC4 Gene

  • Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane.

Gene Wiki entry for EXOC4 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for EXOC4 Gene

Genomics for EXOC4 Gene

Regulatory Elements for EXOC4 Gene

Enhancers for EXOC4 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH07F133912 0.9 Ensembl ENCODE 16.4 +660.4 660361 1.9 MAFG ATF2 JUND ZNF316 FOS NFE2 MAFK NFE2L2 EXOC4 GC07P133912 GC07M133912
GH07F133852 1 Ensembl ENCODE 14.5 +600.7 600700 2.1 CTCF ESRRA SIN3A EBF1 ZNF48 RAD21 ZBTB48 SMC3 PRDM10 FOS EXOC4 GC07P133850 GC07M133860
GH07F133884 0.6 ENCODE 15.3 +631.4 631356 0.2 ZFHX2 GATA2 NR2F1 GLIS1 NR2F6 EGR2 EXOC4 GC07P133885 GC07M133860
GH07F133702 0.7 ENCODE 12.2 +451.7 451684 4.4 JUN SIN3A ZBTB40 ZNF316 ZNF766 TRIM24 FOS ZNF600 MAFK ZNF362 EXOC4 PIR61129 GC07P133674
GH07F133851 0.5 Ensembl 15.4 +598.6 598634 0.2 ZNF316 MAFG EMSY ZNF83 EXOC4 GC07P133850 GC07M133860
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around EXOC4 on UCSC Golden Path with GeneCards custom track

Promoters for EXOC4 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001896472 633 2201 PKNOX1 CREB3L1 ARID4B SIN3A DMAP1 YY1 SLC30A9 ZNF143 FOS CEBPZ

Genomic Location for EXOC4 Gene

Chromosome:
7
Start:
133,253,067 bp from pter
End:
134,066,589 bp from pter
Size:
813,523 bases
Orientation:
Plus strand

Genomic View for EXOC4 Gene

Genes around EXOC4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
EXOC4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for EXOC4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for EXOC4 Gene

Proteins for EXOC4 Gene

  • Protein details for EXOC4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96A65-EXOC4_HUMAN
    Recommended name:
    Exocyst complex component 4
    Protein Accession:
    Q96A65
    Secondary Accessions:
    • E9PED2
    • Q541U8
    • Q9C0G4
    • Q9H9K0
    • Q9P102

    Protein attributes for EXOC4 Gene

    Size:
    974 amino acids
    Molecular mass:
    110498 Da
    Quaternary structure:
    • The exocyst complex is composed of EXOC1, EXOC2, EXOC3, EXOC4, EXOC5, EXOC6, EXOC7 and EXOC8 (By similarity). Interacts with BIRC6/bruce. Interacts with MYRIP (By similarity).

    Alternative splice isoforms for EXOC4 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for EXOC4 Gene

Post-translational modifications for EXOC4 Gene

  • Ubiquitination at Lys 9, Lys 223, Lys 240, and Lys 486
  • Modification sites at PhosphoSitePlus

Other Protein References for EXOC4 Gene

No data available for DME Specific Peptides for EXOC4 Gene

Domains & Families for EXOC4 Gene

Gene Families for EXOC4 Gene

Graphical View of Domain Structure for InterPro Entry

Q96A65

UniProtKB/Swiss-Prot:

EXOC4_HUMAN :
  • Belongs to the SEC8 family.
Family:
  • Belongs to the SEC8 family.
genes like me logo Genes that share domains with EXOC4: view

Function for EXOC4 Gene

Molecular function for EXOC4 Gene

UniProtKB/Swiss-Prot Function:
Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane.

Gene Ontology (GO) - Molecular Function for EXOC4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 17043677
GO:0017160 Ral GTPase binding IPI 24056301
GO:0030165 PDZ domain binding IEA --
GO:0047485 protein N-terminus binding IPI 18480549
genes like me logo Genes that share ontologies with EXOC4: view
genes like me logo Genes that share phenotypes with EXOC4: view

Animal Model Products

miRNA for EXOC4 Gene

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for EXOC4

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for EXOC4 Gene

Localization for EXOC4 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for EXOC4 gene
Compartment Confidence
plasma membrane 5
nucleus 5
cytosol 5
golgi apparatus 2
cytoskeleton 1
endosome 1

Gene Ontology (GO) - Cellular Components for EXOC4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000145 exocyst IEA --
GO:0005737 cytoplasm IDA --
GO:0005829 cytosol TAS --
GO:0005886 plasma membrane TAS --
GO:0005902 microvillus IEA --
genes like me logo Genes that share ontologies with EXOC4: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for EXOC4 Gene

Pathways & Interactions for EXOC4 Gene

genes like me logo Genes that share pathways with EXOC4: view

Gene Ontology (GO) - Biological Process for EXOC4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006810 transport IEA --
GO:0006887 exocytosis IEA --
GO:0006904 vesicle docking involved in exocytosis IEA --
GO:0015031 protein transport IEA --
GO:0016241 regulation of macroautophagy TAS 21241894
genes like me logo Genes that share ontologies with EXOC4: view

No data available for SIGNOR curated interactions for EXOC4 Gene

Transcripts for EXOC4 Gene

Unigene Clusters for EXOC4 Gene

Exocyst complex component 4:
Representative Sequences:

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for EXOC4

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for EXOC4 Gene

No ASD Table

Relevant External Links for EXOC4 Gene

GeneLoc Exon Structure for
EXOC4
ECgene alternative splicing isoforms for
EXOC4

Expression for EXOC4 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for EXOC4 Gene

Protein differential expression in normal tissues from HIPED for EXOC4 Gene

This gene is overexpressed in Bone (20.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for EXOC4 Gene



Protein tissue co-expression partners for EXOC4 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of EXOC4 Gene:

EXOC4

SOURCE GeneReport for Unigene cluster for EXOC4 Gene:

Hs.321273
genes like me logo Genes that share expression patterns with EXOC4: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for EXOC4 Gene

Orthologs for EXOC4 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for EXOC4 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia EXOC4 34 35
  • 99.62 (n)
oppossum
(Monodelphis domestica)
Mammalia EXOC4 35
  • 94 (a)
OneToOne
dog
(Canis familiaris)
Mammalia EXOC4 34 35
  • 91.92 (n)
cow
(Bos Taurus)
Mammalia EXOC4 34 35
  • 91.1 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 90 (a)
OneToMany
-- 35
  • 85 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Exoc4 34
  • 89.36 (n)
mouse
(Mus musculus)
Mammalia Exoc4 34 16 35
  • 89.19 (n)
chicken
(Gallus gallus)
Aves EXOC4 34 35
  • 80.63 (n)
lizard
(Anolis carolinensis)
Reptilia -- 35
  • 88 (a)
OneToMany
-- 35
  • 81 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia exoc4 34
  • 76.59 (n)
zebrafish
(Danio rerio)
Actinopterygii exoc4 34 35
  • 72.83 (n)
fruit fly
(Drosophila melanogaster)
Insecta sec8 34 35
  • 49.52 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP001694 34
  • 49.17 (n)
worm
(Caenorhabditis elegans)
Secernentea sec-8 34 35
  • 44.71 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes SEC8 37
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 39 (a)
OneToOne
Species where no ortholog for EXOC4 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for EXOC4 Gene

ENSEMBL:
Gene Tree for EXOC4 (if available)
TreeFam:
Gene Tree for EXOC4 (if available)

Paralogs for EXOC4 Gene

No data available for Paralogs for EXOC4 Gene

Variants for EXOC4 Gene

Sequence variations from dbSNP and Humsavar for EXOC4 Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type
rs768209201 A colorectal cancer sample 133,895,659(+) TGAGT(A/G)CATAT nc-transcript-variant, reference, missense
VAR_036292 A colorectal cancer sample
rs730882233 Likely pathogenic 133,817,543(+) CCTAC(A/G)GGTAA intron-variant, nc-transcript-variant, reference, missense
rs1003338 -- 133,624,191(+) ATGCC(A/G)CTTCC intron-variant
rs1004149 -- 133,621,386(+) AAATA(C/T)GATTT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for EXOC4 Gene

Variant ID Type Subtype PubMed ID
dgv3668n106 CNV deletion 24896259
dgv3669n106 CNV deletion 24896259
dgv6622n100 CNV loss 25217958
dgv6623n100 CNV loss 25217958
dgv6624n100 CNV loss 25217958
esv1009705 CNV deletion 20482838
esv1010219 CNV insertion 20482838
esv1081495 CNV deletion 17803354
esv1677306 CNV insertion 17803354
esv2121190 CNV deletion 18987734
esv2244756 CNV deletion 18987734
esv2473150 CNV insertion 19546169
esv2491664 CNV deletion 19546169
esv2567326 CNV deletion 19546169
esv2657515 CNV deletion 23128226
esv2662196 CNV deletion 23128226
esv2663117 CNV deletion 23128226
esv2663337 CNV deletion 23128226
esv2669987 CNV deletion 23128226
esv2676200 CNV deletion 23128226
nsv970942 CNV duplication 23825009
nsv957579 CNV deletion 24416366
nsv831144 CNV loss 17160897
nsv831143 CNV gain 17160897
nsv608444 CNV gain 21841781
nsv608443 CNV loss 21841781
nsv608442 CNV gain 21841781
nsv608441 CNV loss 21841781
nsv608440 CNV loss 21841781
nsv5956 CNV insertion 18451855
nsv5955 CNV deletion 18451855
nsv528972 CNV loss 19592680
nsv525065 CNV loss 19592680
nsv521054 CNV loss 19592680
nsv474551 CNV novel sequence insertion 20440878
nsv473486 CNV novel sequence insertion 20440878
nsv470393 CNV gain 18288195
nsv464725 CNV loss 19166990
nsv428186 CNV gain 18775914
nsv366574 CNV deletion 16902084
nsv1153540 CNV deletion 26484159
nsv1152760 CNV duplication 26484159
nsv1147242 CNV insertion 26484159
nsv1132087 CNV deletion 24896259
nsv1075998 CNV deletion 25765185
nsv1034741 CNV loss 25217958
nsv1033168 CNV loss 25217958
nsv1032205 CNV gain 25217958
nsv1031721 CNV loss 25217958
nsv1028914 CNV loss 25217958
nsv1020795 CNV loss 25217958
nsv1020759 CNV gain 25217958
nsv1018425 CNV loss 25217958
esv999690 CNV deletion 20482838
esv9349 CNV loss 19470904
esv5070 CNV loss 18987735
esv3615088 CNV loss 21293372
esv3615087 CNV loss 21293372
esv3615086 CNV loss 21293372
esv3615085 CNV loss 21293372
esv3615084 CNV gain 21293372
esv3615083 CNV gain 21293372
esv3615082 CNV gain 21293372
esv3615081 CNV loss 21293372
esv3615078 CNV loss 21293372
esv3615077 CNV gain 21293372
esv3615076 CNV loss 21293372
esv3615074 CNV loss 21293372
esv3615073 CNV loss 21293372
esv3615072 CNV loss 21293372
esv3615069 CNV loss 21293372
esv3615068 CNV loss 21293372
esv3615067 CNV loss 21293372
esv3572150 CNV loss 25503493
esv3572147 CNV loss 25503493
esv3572146 CNV loss 25503493
esv3542458 CNV deletion 23714750
esv3542452 CNV deletion 23714750
esv3542451 CNV deletion 23714750
esv3446426 CNV insertion 20981092
esv3443112 CNV insertion 20981092
esv3428337 CNV insertion 20981092
esv3361602 CNV insertion 20981092
esv2764007 CNV loss 21179565
esv2759565 CNV gain 17122850
esv2735175 CNV deletion 23290073
esv2735174 CNV deletion 23290073
esv2735172 CNV deletion 23290073
dgv237n6 CNV deletion 16902084

Variation tolerance for EXOC4 Gene

Residual Variation Intolerance Score: 16.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.76; 46.99% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for EXOC4 Gene

Human Gene Mutation Database (HGMD)
EXOC4
SNPedia medical, phenotypic, and genealogical associations of SNPs for
EXOC4

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for EXOC4 Gene

Disorders for EXOC4 Gene

Relevant External Links for EXOC4

Genetic Association Database (GAD)
EXOC4
Human Genome Epidemiology (HuGE) Navigator
EXOC4
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
EXOC4

No disorders were found for EXOC4 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for EXOC4 Gene

Publications for EXOC4 Gene

  1. Prediction of the coding sequences of unidentified human genes. XIX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 11214970) Nagase T. … Ohara O. (DNA Res. 2000) 2 3 4 64
  2. Screening for replication of genome-wide SNP associations in sporadic ALS. (PMID: 18987618) Cronin S. … Hardiman O. (Eur. J. Hum. Genet. 2009) 3 46 64
  3. Final stages of cytokinesis and midbody ring formation are controlled by BRUCE. (PMID: 18329369) Pohl C. … Jentsch S. (Cell 2008) 3 4 64
  4. Polymorphisms near EXOC4 and LRGUK on chromosome 7q32 are associated with Type 2 Diabetes and fasting glucose; the NHLBI Family Heart Study. (PMID: 18498660) Laramie J.M. … Myers R.H. (BMC Med. Genet. 2008) 3 46 64
  5. Framingham Heart Study 100K Project: genome-wide associations for blood pressure and arterial stiffness. (PMID: 17903302) Levy D. … Mitchell G.F. (BMC Med. Genet. 2007) 3 46 64

Products for EXOC4 Gene

Sources for EXOC4 Gene

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