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Aliases for EXOC3L1 Gene

Aliases for EXOC3L1 Gene

  • Exocyst Complex Component 3 Like 1 2 3 5
  • Protein Jiangli 3 4
  • EXOC3L 3 4
  • Exocyst Complex Component 3-Like Protein 3
  • Exocyst Complex Component 3-Like 1 2
  • Exocyst Complex Component 3-Like 2

External Ids for EXOC3L1 Gene

Previous HGNC Symbols for EXOC3L1 Gene

  • EXOC3L

Previous GeneCards Identifiers for EXOC3L1 Gene

  • GC16M067219

Summaries for EXOC3L1 Gene

GeneCards Summary for EXOC3L1 Gene

EXOC3L1 (Exocyst Complex Component 3 Like 1) is a Protein Coding gene. GO annotations related to this gene include SNARE binding. An important paralog of this gene is EXOC3.

UniProtKB/Swiss-Prot for EXOC3L1 Gene

  • As part of the exocyst, may play a role in regulated exocytosis of insulin granules.

Gene Wiki entry for EXOC3L1 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for EXOC3L1 Gene

Genomics for EXOC3L1 Gene

Regulatory Elements for EXOC3L1 Gene

Enhancers for EXOC3L1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH16G066902 2.3 VISTA FANTOM5 Ensembl ENCODE dbSUPER 9.9 +285.7 285664 4.1 PKNOX1 FOXA2 MLX ARNT ARID4B DMAP1 ZNF2 ZNF48 YY1 SP5 CES2 KIAA0895L E2F4 RRAD FAM96B CENPT EXOC3L1 C16orf70 CES3 LINC00920
GH16G066899 1.7 Ensembl ENCODE dbSUPER 9.9 +289.5 289477 3.4 CREB3L1 DMAP1 YY1 SLC30A9 ZNF143 SP3 NFYC MEF2D SSRP1 ZNF610 CES2 E2F4 RRAD FAM96B LINC00920 TRADD FBXL8 HSF4 PLEKHG4 EXOC3L1
GH16G066977 1.5 Ensembl ENCODE dbSUPER 10.4 +212.4 212404 0.4 HDGF WRNIP1 ARID4B SIN3A ZNF2 ZNF48 SLC30A9 GLIS2 ZNF143 DEK CES2 ELMO3 CBFB B3GNT9 FBXL8 TRADD HSF4 C16orf70 RRAD CDH16
GH16G067216 1.1 Ensembl ENCODE 12.4 -27.0 -27040 1.2 HDAC1 HDGF PKNOX1 NFRKB RAD21 GATA2 USF2 NR2F2 ZNF592 ZNF579 ATP6V0D1 EXOC3L1 E2F4 KIAA0895L CES2 CDH16 RRAD ZDHHC1 LOC105369155 GC16M067211
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around EXOC3L1 on UCSC Golden Path with GeneCards custom track

Genomic Location for EXOC3L1 Gene

67,184,366 bp from pter
67,190,204 bp from pter
5,839 bases
Minus strand

Genomic View for EXOC3L1 Gene

Genes around EXOC3L1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
EXOC3L1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for EXOC3L1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for EXOC3L1 Gene

Proteins for EXOC3L1 Gene

  • Protein details for EXOC3L1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Exocyst complex component 3-like protein
    Protein Accession:
    Secondary Accessions:
    • A8K7I9
    • Q8NAD2
    • Q8TEN2

    Protein attributes for EXOC3L1 Gene

    746 amino acids
    Molecular mass:
    81678 Da
    Quaternary structure:
    • Interacts with EXOC2, EXOC4 and EXOC5; may be part of the exocyst.

neXtProt entry for EXOC3L1 Gene

Post-translational modifications for EXOC3L1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for EXOC3L1 Gene

No data available for DME Specific Peptides for EXOC3L1 Gene

Domains & Families for EXOC3L1 Gene

Protein Domains for EXOC3L1 Gene

Suggested Antigen Peptide Sequences for EXOC3L1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the SEC6 family.
  • Belongs to the SEC6 family.
genes like me logo Genes that share domains with EXOC3L1: view

No data available for Gene Families for EXOC3L1 Gene

Function for EXOC3L1 Gene

Molecular function for EXOC3L1 Gene

UniProtKB/Swiss-Prot Function:
As part of the exocyst, may play a role in regulated exocytosis of insulin granules.

Gene Ontology (GO) - Molecular Function for EXOC3L1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000149 SNARE binding IBA --
GO:0003674 molecular_function ND --
genes like me logo Genes that share ontologies with EXOC3L1: view

Phenotypes for EXOC3L1 Gene

genes like me logo Genes that share phenotypes with EXOC3L1: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for EXOC3L1 Gene

Localization for EXOC3L1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for EXOC3L1 Gene

Cytoplasmic vesicle, secretory vesicle. Note=Colocalizes with insulin granules. {ECO:0000250}.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for EXOC3L1 gene
Compartment Confidence
nucleus 3
cytosol 2
peroxisome 1

Gene Ontology (GO) - Cellular Components for EXOC3L1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000145 exocyst ISS 18480549
GO:0030133 transport vesicle IEA --
GO:0030141 secretory granule ISS 18480549
GO:0031410 cytoplasmic vesicle IEA --
genes like me logo Genes that share ontologies with EXOC3L1: view

Pathways & Interactions for EXOC3L1 Gene

SuperPathways for EXOC3L1 Gene

No Data Available

Interacting Proteins for EXOC3L1 Gene

Gene Ontology (GO) - Biological Process for EXOC3L1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006887 exocytosis ISS,IEA 18480549
GO:0030072 peptide hormone secretion ISS 18480549
GO:0051601 exocyst localization IBA --
genes like me logo Genes that share ontologies with EXOC3L1: view

No data available for Pathways by source and SIGNOR curated interactions for EXOC3L1 Gene

Drugs & Compounds for EXOC3L1 Gene

No Compound Related Data Available

Transcripts for EXOC3L1 Gene

Unigene Clusters for EXOC3L1 Gene

Exocyst complex component 3-like 1:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for EXOC3L1 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3a · 3b ^ 4a · 4b ^ 5a · 5b ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10a · 10b ^ 11 ^ 12 ^ 13 ^ 14a · 14b
SP1: - - -
SP2: - - - -
SP3: - - - - - -
SP4: -
SP5: - - - - - -

Relevant External Links for EXOC3L1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for EXOC3L1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for EXOC3L1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for EXOC3L1 Gene

This gene is overexpressed in Spleen (x15.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for EXOC3L1 Gene

Protein tissue co-expression partners for EXOC3L1 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of EXOC3L1 Gene:


SOURCE GeneReport for Unigene cluster for EXOC3L1 Gene:


Evidence on tissue expression from TISSUES for EXOC3L1 Gene

  • Spleen(4.3)
  • Intestine(4.1)
genes like me logo Genes that share expression patterns with EXOC3L1: view

Primer Products

No data available for Protein differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for EXOC3L1 Gene

Orthologs for EXOC3L1 Gene

This gene was present in the common ancestor of animals.

Orthologs for EXOC3L1 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia EXOC3L1 34 35
  • 99.37 (n)
(Canis familiaris)
Mammalia KIAA0895L 34
  • 84.35 (n)
EXOC3L1 35
  • 71 (a)
(Bos Taurus)
Mammalia EXOC3L1 34 35
  • 83.81 (n)
(Rattus norvegicus)
Mammalia Exoc3l1 34
  • 81.21 (n)
(Mus musculus)
Mammalia Exoc3l 34 16 35
  • 79.99 (n)
(Monodelphis domestica)
Mammalia EXOC3L1 35
  • 59 (a)
(Gallus gallus)
Aves EXOC3L1 34 35
  • 56.37 (n)
(Anolis carolinensis)
Reptilia EXOC3L1 35
  • 39 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia exoc3l1 34
  • 49.79 (n)
(Danio rerio)
Actinopterygii exoc3l1 34 35
  • 48.09 (n)
fruit fly
(Drosophila melanogaster)
Insecta sec6 35
  • 22 (a)
(Caenorhabditis elegans)
Secernentea sec-6 35
  • 20 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 26 (a)
Species where no ortholog for EXOC3L1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for EXOC3L1 Gene

Gene Tree for EXOC3L1 (if available)
Gene Tree for EXOC3L1 (if available)

Paralogs for EXOC3L1 Gene

Paralogs for EXOC3L1 Gene

(2) SIMAP similar genes for EXOC3L1 Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with EXOC3L1: view

Variants for EXOC3L1 Gene

Sequence variations from dbSNP and Humsavar for EXOC3L1 Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type
rs117403380 A breast cancer sample 67,188,925(+) CAGGT(A/T)TGACT reference, missense
rs142958191 A breast cancer sample 67,185,446(+) CCAAG(G/T)CCCCT upstream-variant-2KB, reference, missense
rs1001789917 -- 67,184,220(+) AACGC(A/C)GTCTG intron-variant, upstream-variant-2KB
rs1002312187 -- 67,192,088(+) GCGCC(A/G/T)CGTTC upstream-variant-2KB
rs1002926835 -- 67,191,340(+) GTCTC(-/A)AAAAA upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for EXOC3L1 Gene

Variant ID Type Subtype PubMed ID
nsv1160429 CNV deletion 26073780
nsv457513 CNV loss 19166990
nsv471092 CNV gain 18288195
nsv522852 CNV gain 19592680
nsv524363 CNV loss 19592680
nsv524492 CNV loss 19592680
nsv572905 CNV loss 21841781
nsv827707 CNV loss 20364138
nsv952044 CNV deletion 24416366

Variation tolerance for EXOC3L1 Gene

Residual Variation Intolerance Score: 95.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 7.88; 83.69% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for EXOC3L1 Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for EXOC3L1 Gene

Disorders for EXOC3L1 Gene

Relevant External Links for EXOC3L1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for EXOC3L1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for EXOC3L1 Gene

Publications for EXOC3L1 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 3 64
  3. Genetic meta-analysis of 15,901 African Americans identifies variation in EXOC3L1 is associated with HDL concentration. (PMID: 26199122) Lanktree M.B. … Keating B.J. (J. Lipid Res. 2015) 3 64
  4. Genome-wide association study of coronary heart disease and its risk factors in 8,090 African Americans: the NHLBI CARe Project. (PMID: 21347282) Lettre G. … Boerwinkle E. (PLoS Genet. 2011) 3 64
  5. Involvement of Exoc3l, a protein structurally related to the exocyst subunit Sec6, in insulin secretion. (PMID: 18480549) Saito T. … Seino S. (Biomed. Res. 2008) 3 64

Products for EXOC3L1 Gene

Sources for EXOC3L1 Gene

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