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Aliases for EXOC3L1 Gene

Aliases for EXOC3L1 Gene

  • Exocyst Complex Component 3 Like 1 2 3
  • Exocyst Complex Component 3-Like 1 2 3 5
  • Protein Jiangli 3 4
  • EXOC3L 3 4
  • Exocyst Complex Component 3-Like 2

External Ids for EXOC3L1 Gene

Previous HGNC Symbols for EXOC3L1 Gene

  • EXOC3L

Previous GeneCards Identifiers for EXOC3L1 Gene

  • GC16M067219

Summaries for EXOC3L1 Gene

GeneCards Summary for EXOC3L1 Gene

EXOC3L1 (Exocyst Complex Component 3 Like 1) is a Protein Coding gene. GO annotations related to this gene include SNARE binding. An important paralog of this gene is TNFAIP2.

UniProtKB/Swiss-Prot for EXOC3L1 Gene

  • As part of the exocyst, may play a role in regulated exocytosis of insulin granules.

Gene Wiki entry for EXOC3L1 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for EXOC3L1 Gene

Genomics for EXOC3L1 Gene

Regulatory Elements for EXOC3L1 Gene

Enhancers for EXOC3L1 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around EXOC3L1 on UCSC Golden Path with GeneCards custom track

Genomic Location for EXOC3L1 Gene

Chromosome:
16
Start:
67,184,366 bp from pter
End:
67,190,204 bp from pter
Size:
5,839 bases
Orientation:
Minus strand

Genomic View for EXOC3L1 Gene

Genes around EXOC3L1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
EXOC3L1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for EXOC3L1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for EXOC3L1 Gene

Proteins for EXOC3L1 Gene

  • Protein details for EXOC3L1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q86VI1-EX3L1_HUMAN
    Recommended name:
    Exocyst complex component 3-like protein
    Protein Accession:
    Q86VI1
    Secondary Accessions:
    • A8K7I9
    • Q8NAD2
    • Q8TEN2

    Protein attributes for EXOC3L1 Gene

    Size:
    746 amino acids
    Molecular mass:
    81678 Da
    Quaternary structure:
    • Interacts with EXOC2, EXOC4 and EXOC5; may be part of the exocyst.

neXtProt entry for EXOC3L1 Gene

Proteomics data for EXOC3L1 Gene at MOPED

Post-translational modifications for EXOC3L1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for EXOC3L1 Gene

Antibody Products

No data available for DME Specific Peptides for EXOC3L1 Gene

Domains & Families for EXOC3L1 Gene

Protein Domains for EXOC3L1 Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for EXOC3L1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q86VI1

UniProtKB/Swiss-Prot:

EX3L1_HUMAN :
  • Belongs to the SEC6 family.
Family:
  • Belongs to the SEC6 family.
genes like me logo Genes that share domains with EXOC3L1: view

No data available for Gene Families for EXOC3L1 Gene

Function for EXOC3L1 Gene

Molecular function for EXOC3L1 Gene

UniProtKB/Swiss-Prot Function:
As part of the exocyst, may play a role in regulated exocytosis of insulin granules.

Gene Ontology (GO) - Molecular Function for EXOC3L1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000149 SNARE binding IBA --
genes like me logo Genes that share ontologies with EXOC3L1: view

Phenotypes for EXOC3L1 Gene

genes like me logo Genes that share phenotypes with EXOC3L1: view

Animal Model Products

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for EXOC3L1 Gene

Localization for EXOC3L1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for EXOC3L1 Gene

Cytoplasmic vesicle, secretory vesicle. Note=Colocalizes with insulin granules. {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for EXOC3L1 Gene COMPARTMENTS Subcellular localization image for EXOC3L1 gene
Compartment Confidence
nucleus 3
cytosol 2
peroxisome 1

No data available for Gene Ontology (GO) - Cellular Components for EXOC3L1 Gene

Pathways & Interactions for EXOC3L1 Gene

SuperPathways for EXOC3L1 Gene

No Data Available

Interacting Proteins for EXOC3L1 Gene

Gene Ontology (GO) - Biological Process for EXOC3L1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0051601 exocyst localization IBA --
genes like me logo Genes that share ontologies with EXOC3L1: view

No data available for Pathways by source and SIGNOR curated interactions for EXOC3L1 Gene

Drugs & Compounds for EXOC3L1 Gene

No Compound Related Data Available

Transcripts for EXOC3L1 Gene

Unigene Clusters for EXOC3L1 Gene

Exocyst complex component 3-like 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for EXOC3L1 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3a · 3b ^ 4a · 4b ^ 5a · 5b ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10a · 10b ^ 11 ^ 12 ^ 13 ^ 14a · 14b
SP1: - - -
SP2: - - - -
SP3: - - - - - -
SP4: -
SP5: - - - - - -
SP6:

Relevant External Links for EXOC3L1 Gene

GeneLoc Exon Structure for
EXOC3L1
ECgene alternative splicing isoforms for
EXOC3L1

Expression for EXOC3L1 Gene

mRNA expression in normal human tissues for EXOC3L1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for EXOC3L1 Gene

This gene is overexpressed in Spleen (x15.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for EXOC3L1 Gene



SOURCE GeneReport for Unigene cluster for EXOC3L1 Gene Hs.647356

genes like me logo Genes that share expression patterns with EXOC3L1: view

Protein tissue co-expression partners for EXOC3L1 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for Protein differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for EXOC3L1 Gene

Orthologs for EXOC3L1 Gene

This gene was present in the common ancestor of animals.

Orthologs for EXOC3L1 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia EXOC3L1 35
  • 83.81 (n)
  • 79.84 (a)
EXOC3L1 36
  • 80 (a)
OneToOne
dog
(Canis familiaris)
Mammalia KIAA0895L 35
  • 84.35 (n)
  • 81.87 (a)
EXOC3L1 36
  • 71 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Exoc3l 35
  • 79.99 (n)
  • 78.73 (a)
Exoc3l 16
Exoc3l 36
  • 79 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia EXOC3L1 35
  • 99.37 (n)
  • 99.2 (a)
EXOC3L1 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Exoc3l1 35
  • 81.21 (n)
  • 80.08 (a)
oppossum
(Monodelphis domestica)
Mammalia EXOC3L1 36
  • 59 (a)
OneToOne
chicken
(Gallus gallus)
Aves EXOC3L1 35
  • 56.37 (n)
  • 43.81 (a)
EXOC3L1 36
  • 42 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia EXOC3L1 36
  • 39 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia exoc3l1 35
  • 49.79 (n)
  • 40.76 (a)
zebrafish
(Danio rerio)
Actinopterygii exoc3l1 35
  • 48.09 (n)
  • 38.93 (a)
exoc3l1 36
  • 36 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta sec6 36
  • 22 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea sec-6 36
  • 20 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 26 (a)
OneToMany
Species with no ortholog for EXOC3L1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for EXOC3L1 Gene

ENSEMBL:
Gene Tree for EXOC3L1 (if available)
TreeFam:
Gene Tree for EXOC3L1 (if available)

Paralogs for EXOC3L1 Gene

Paralogs for EXOC3L1 Gene

(2) SIMAP similar genes for EXOC3L1 Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with EXOC3L1: view

Variants for EXOC3L1 Gene

Sequence variations from dbSNP and Humsavar for EXOC3L1 Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type
VAR_036959 -
VAR_036960 -
VAR_037002 A breast cancer sample
VAR_037003 A breast cancer sample
rs13334403 -- 67,188,773(+) TGCTG(A/G)GCAAC reference, synonymous-codon

Structural Variations from Database of Genomic Variants (DGV) for EXOC3L1 Gene

Variant ID Type Subtype PubMed ID
dgv2885n71 CNV Loss 21882294
nsv906794 CNV Loss 21882294
dgv2886n71 CNV Loss 21882294
dgv2887n71 CNV Loss 21882294
dgv2888n71 CNV Loss 21882294
nsv524363 CNV Loss 19592680
nsv827707 CNV Loss 20364138
nsv906803 CNV Loss 21882294
nsv522852 CNV Gain 19592680
nsv524492 CNV Loss 19592680
nsv471092 CNV Gain 18288195
nsv457513 CNV Loss 19166990
dgv2889n71 CNV Loss 21882294

Variation tolerance for EXOC3L1 Gene

Residual Variation Intolerance Score: 95.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 7.88; 83.69% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for EXOC3L1 Gene

HapMap Linkage Disequilibrium report
EXOC3L1
Human Gene Mutation Database (HGMD)
EXOC3L1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for EXOC3L1 Gene

Disorders for EXOC3L1 Gene

Relevant External Links for EXOC3L1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
EXOC3L1

No disorders were found for EXOC3L1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for EXOC3L1 Gene

Publications for EXOC3L1 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 67
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 3
  3. Genome-wide association study of coronary heart disease and its risk factors in 8,090 African Americans: the NHLBI CARe Project. (PMID: 21347282) Lettre G. … Boerwinkle E. (PLoS Genet. 2011) 3
  4. Involvement of Exoc3l, a protein structurally related to the exocyst subunit Sec6, in insulin secretion. (PMID: 18480549) Saito T. … Seino S. (Biomed. Res. 2008) 3
  5. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K. … Sugano S. (Genome Res. 2006) 3

Products for EXOC3L1 Gene

Sources for EXOC3L1 Gene

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