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Aliases for EXOC3L1 Gene

Aliases for EXOC3L1 Gene

  • Exocyst Complex Component 3 Like 1 2 3 5
  • Protein Jiangli 3 4
  • EXOC3L 3 4
  • Exocyst Complex Component 3-Like Protein 3
  • Exocyst Complex Component 3-Like 1 2
  • Exocyst Complex Component 3-Like 2

External Ids for EXOC3L1 Gene

Previous HGNC Symbols for EXOC3L1 Gene

  • EXOC3L

Previous GeneCards Identifiers for EXOC3L1 Gene

  • GC16M067219

Summaries for EXOC3L1 Gene

GeneCards Summary for EXOC3L1 Gene

EXOC3L1 (Exocyst Complex Component 3 Like 1) is a Protein Coding gene. GO annotations related to this gene include SNARE binding. An important paralog of this gene is EXOC3.

UniProtKB/Swiss-Prot for EXOC3L1 Gene

  • As part of the exocyst, may play a role in regulated exocytosis of insulin granules.

Gene Wiki entry for EXOC3L1 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for EXOC3L1 Gene

Genomics for EXOC3L1 Gene

Regulatory Elements for EXOC3L1 Gene

Enhancers for EXOC3L1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH16F067216 0.7 Ensembl ENCODE 12.4 -27.0 -26997 2.0 HDAC1 PKNOX1 ZMYM3 GATA2 POLR2A ZNF169 ZNF263 L3MBTL2 BHLHE40 USF2 ATP6V0D1 EXOC3L1 E2F4 KIAA0895L CES2 CDH16 RRAD ZDHHC1 DPEP2 GC16M067211
GH16F066960 0.9 ENCODE 11.1 +229.1 229116 0.9 ELF3 HDGF PKNOX1 SIN3A ARID4B ZNF48 ZBTB40 ZSCAN9 DNMT3B ZNF2 TRADD FBXL8 HSF4 CES2 RRAD CDH16 FAM96B B3GNT9 CBFB ELMO3
GH16F067092 0.4 ENCODE 10.5 +97.8 97792 0.2 FOS PRDM1 CBFB KIAA0895L E2F4 EXOC3L1 ELMO3 MIR328 GC16P067102
GH16F067137 0.2 ENCODE 10.4 +52.4 52412 0.2 PKNOX1 NFIA PBX2 ZBTB17 TRADD FBXL8 HSF4 NOL3 CBFB KIAA0895L E2F4 EXOC3L1 CES2 CDH16
GH16F066977 1.2 Ensembl ENCODE 10.4 +212.4 212404 0.4 HDGF WRNIP1 ARID4B ZNF48 ZNF2 SLC30A9 GLIS2 ZNF143 DEK SP5 CES2 ELMO3 CBFB B3GNT9 FBXL8 TRADD HSF4 C16orf70 RRAD CDH16
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around EXOC3L1 on UCSC Golden Path with GeneCards custom track

Promoters for EXOC3L1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001802280 404 401

Genomic Location for EXOC3L1 Gene

Chromosome:
16
Start:
67,184,366 bp from pter
End:
67,190,204 bp from pter
Size:
5,839 bases
Orientation:
Minus strand

Genomic View for EXOC3L1 Gene

Genes around EXOC3L1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
EXOC3L1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for EXOC3L1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for EXOC3L1 Gene

Proteins for EXOC3L1 Gene

  • Protein details for EXOC3L1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q86VI1-EX3L1_HUMAN
    Recommended name:
    Exocyst complex component 3-like protein
    Protein Accession:
    Q86VI1
    Secondary Accessions:
    • A8K7I9
    • Q8NAD2
    • Q8TEN2

    Protein attributes for EXOC3L1 Gene

    Size:
    746 amino acids
    Molecular mass:
    81678 Da
    Quaternary structure:
    • Interacts with EXOC2, EXOC4 and EXOC5; may be part of the exocyst.

neXtProt entry for EXOC3L1 Gene

Post-translational modifications for EXOC3L1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for EXOC3L1 Gene

No data available for DME Specific Peptides for EXOC3L1 Gene

Domains & Families for EXOC3L1 Gene

Protein Domains for EXOC3L1 Gene

Suggested Antigen Peptide Sequences for EXOC3L1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q86VI1

UniProtKB/Swiss-Prot:

EX3L1_HUMAN :
  • Belongs to the SEC6 family.
Family:
  • Belongs to the SEC6 family.
genes like me logo Genes that share domains with EXOC3L1: view

No data available for Gene Families for EXOC3L1 Gene

Function for EXOC3L1 Gene

Molecular function for EXOC3L1 Gene

UniProtKB/Swiss-Prot Function:
As part of the exocyst, may play a role in regulated exocytosis of insulin granules.

Gene Ontology (GO) - Molecular Function for EXOC3L1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000149 SNARE binding IBA --
GO:0003674 molecular_function ND --
genes like me logo Genes that share ontologies with EXOC3L1: view

Phenotypes for EXOC3L1 Gene

genes like me logo Genes that share phenotypes with EXOC3L1: view

Animal Model Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for EXOC3L1 Gene

Localization for EXOC3L1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for EXOC3L1 Gene

Cytoplasmic vesicle, secretory vesicle. Note=Colocalizes with insulin granules. {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for EXOC3L1 Gene COMPARTMENTS Subcellular localization image for EXOC3L1 gene
Compartment Confidence
nucleus 3
cytosol 2
peroxisome 1

Gene Ontology (GO) - Cellular Components for EXOC3L1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000145 exocyst ISS 18480549
GO:0030133 transport vesicle IEA --
GO:0030141 secretory granule ISS 18480549
GO:0031410 cytoplasmic vesicle IEA --
genes like me logo Genes that share ontologies with EXOC3L1: view

Pathways & Interactions for EXOC3L1 Gene

SuperPathways for EXOC3L1 Gene

No Data Available

Interacting Proteins for EXOC3L1 Gene

Gene Ontology (GO) - Biological Process for EXOC3L1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006887 exocytosis IEA,ISS 18480549
GO:0030072 peptide hormone secretion ISS 18480549
GO:0051601 exocyst localization IBA --
genes like me logo Genes that share ontologies with EXOC3L1: view

No data available for Pathways by source and SIGNOR curated interactions for EXOC3L1 Gene

Transcripts for EXOC3L1 Gene

Unigene Clusters for EXOC3L1 Gene

Exocyst complex component 3-like 1:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for EXOC3L1 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3a · 3b ^ 4a · 4b ^ 5a · 5b ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10a · 10b ^ 11 ^ 12 ^ 13 ^ 14a · 14b
SP1: - - -
SP2: - - - -
SP3: - - - - - -
SP4: -
SP5: - - - - - -
SP6:

Relevant External Links for EXOC3L1 Gene

GeneLoc Exon Structure for
EXOC3L1
ECgene alternative splicing isoforms for
EXOC3L1

Expression for EXOC3L1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for EXOC3L1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for EXOC3L1 Gene

This gene is overexpressed in Spleen (x15.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for EXOC3L1 Gene



Protein tissue co-expression partners for EXOC3L1 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of EXOC3L1 Gene:

EXOC3L1

SOURCE GeneReport for Unigene cluster for EXOC3L1 Gene:

Hs.647356
genes like me logo Genes that share expression patterns with EXOC3L1: view

Primer Products

No data available for Protein differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for EXOC3L1 Gene

Orthologs for EXOC3L1 Gene

This gene was present in the common ancestor of animals.

Orthologs for EXOC3L1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia EXOC3L1 35 34
  • 99.37 (n)
OneToOne
dog
(Canis familiaris)
Mammalia KIAA0895L 34
  • 84.35 (n)
EXOC3L1 35
  • 71 (a)
OneToOne
cow
(Bos Taurus)
Mammalia EXOC3L1 34 35
  • 83.81 (n)
rat
(Rattus norvegicus)
Mammalia Exoc3l1 34
  • 81.21 (n)
mouse
(Mus musculus)
Mammalia Exoc3l 34 16 35
  • 79.99 (n)
oppossum
(Monodelphis domestica)
Mammalia EXOC3L1 35
  • 59 (a)
OneToOne
chicken
(Gallus gallus)
Aves EXOC3L1 35 34
  • 56.37 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia EXOC3L1 35
  • 39 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia exoc3l1 34
  • 49.79 (n)
zebrafish
(Danio rerio)
Actinopterygii exoc3l1 35 34
  • 48.09 (n)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta sec6 35
  • 22 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea sec-6 35
  • 20 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 26 (a)
OneToMany
Species where no ortholog for EXOC3L1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for EXOC3L1 Gene

ENSEMBL:
Gene Tree for EXOC3L1 (if available)
TreeFam:
Gene Tree for EXOC3L1 (if available)

Paralogs for EXOC3L1 Gene

Paralogs for EXOC3L1 Gene

(2) SIMAP similar genes for EXOC3L1 Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with EXOC3L1: view

Variants for EXOC3L1 Gene

Sequence variations from dbSNP and Humsavar for EXOC3L1 Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type
rs117403380 A breast cancer sample 67,188,925(+) CAGGT(A/T)TGACT reference, missense
rs142958191 A breast cancer sample 67,185,446(+) CCAAG(G/T)CCCCT upstream-variant-2KB, reference, missense
rs111426396 -- 67,186,512(+) GCCTG(A/G)GGAGC intron-variant
rs111513602 -- 67,185,093(+) CGCCT(C/G)TCACC intron-variant, upstream-variant-2KB
rs111591532 -- 67,189,377(+) GTTCA(A/G)GCGAT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for EXOC3L1 Gene

Variant ID Type Subtype PubMed ID
nsv1160429 CNV deletion 26073780
nsv457513 CNV loss 19166990
nsv471092 CNV gain 18288195
nsv522852 CNV gain 19592680
nsv524363 CNV loss 19592680
nsv524492 CNV loss 19592680
nsv572905 CNV loss 21841781
nsv827707 CNV loss 20364138
nsv952044 CNV deletion 24416366

Variation tolerance for EXOC3L1 Gene

Residual Variation Intolerance Score: 95.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 7.88; 83.69% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for EXOC3L1 Gene

Human Gene Mutation Database (HGMD)
EXOC3L1
SNPedia medical, phenotypic, and genealogical associations of SNPs for
EXOC3L1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for EXOC3L1 Gene

Disorders for EXOC3L1 Gene

Relevant External Links for EXOC3L1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
EXOC3L1

No disorders were found for EXOC3L1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for EXOC3L1 Gene

Publications for EXOC3L1 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 3 64
  3. Genetic meta-analysis of 15,901 African Americans identifies variation in EXOC3L1 is associated with HDL concentration. (PMID: 26199122) Lanktree M.B. … Keating B.J. (J. Lipid Res. 2015) 3 64
  4. Genome-wide association study of coronary heart disease and its risk factors in 8,090 African Americans: the NHLBI CARe Project. (PMID: 21347282) Lettre G. … Boerwinkle E. (PLoS Genet. 2011) 3 64
  5. Involvement of Exoc3l, a protein structurally related to the exocyst subunit Sec6, in insulin secretion. (PMID: 18480549) Saito T. … Seino S. (Biomed. Res. 2008) 3 64

Products for EXOC3L1 Gene

Sources for EXOC3L1 Gene

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