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Aliases for EXOC3 Gene

Aliases for EXOC3 Gene

  • Exocyst Complex Component 3 2 3
  • Exocyst Complex Component Sec6 3 4
  • SEC6L1 3 4
  • SEC6 3 4
  • SEC6-Like 1 (S. Cerevisiae) 2
  • Sec 6 Homolog 3
  • SEC6-Like 1 3
  • Sec6p 3

External Ids for EXOC3 Gene

Previous HGNC Symbols for EXOC3 Gene

  • SEC6L1

Previous GeneCards Identifiers for EXOC3 Gene

  • GC05P000497

Summaries for EXOC3 Gene

Entrez Gene Summary for EXOC3 Gene

  • The protein encoded by this gene is a component of the exocyst complex, a multiple protein complex essential for targeting exocytic vesicles to specific docking sites on the plasma membrane. Though best characterized in yeast, the component proteins and functions of exocyst complex have been demonstrated to be highly conserved in higher eukaryotes. At least eight components of the exocyst complex, including this protein, are found to interact with the actin cytoskeletal remodeling and vesicle transport machinery. The complex is also essential for the biogenesis of epithelial cell surface polarity. [provided by RefSeq, Jul 2008]

GeneCards Summary for EXOC3 Gene

EXOC3 (Exocyst Complex Component 3) is a Protein Coding gene. Among its related pathways are Organelle biogenesis and maintenance and Actin Nucleation by ARP-WASP Complex. GO annotations related to this gene include SNARE binding. An important paralog of this gene is TNFAIP2.

UniProtKB/Swiss-Prot for EXOC3 Gene

  • Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane

Gene Wiki entry for EXOC3 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for EXOC3 Gene

Genomics for EXOC3 Gene

Genomic Location for EXOC3 Gene

Chromosome:
5
Start:
443,158 bp from pter
End:
471,937 bp from pter
Size:
28,780 bases
Orientation:
Plus strand

Genomic View for EXOC3 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for EXOC3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for EXOC3 Gene

Proteins for EXOC3 Gene

  • Protein details for EXOC3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O60645-EXOC3_HUMAN
    Recommended name:
    Exocyst complex component 3
    Protein Accession:
    O60645
    Secondary Accessions:
    • Q6P2E8
    • Q8TEN6
    • Q8WUW0
    • Q96DI4

    Protein attributes for EXOC3 Gene

    Size:
    756 amino acids
    Molecular mass:
    86845 Da
    Quaternary structure:
    • The exocyst complex is composed of EXOC1, EXOC2, EXOC3, EXOC4, EXOC5, EXOC6, EXOC7 and EXOC8. Interacts with EXOC3L1 (By similarity). Interacts with BIRC6/bruce. Interacts with MYRIP (By similarity).
    SequenceCaution:
    • Sequence=BAB84912.1; Type=Frameshift; Positions=1, 563; Evidence={ECO:0000305};

    Alternative splice isoforms for EXOC3 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for EXOC3 Gene

Proteomics data for EXOC3 Gene at MOPED

Post-translational modifications for EXOC3 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for EXOC3 Gene

Antibody Products

No data available for DME Specific Peptides for EXOC3 Gene

Domains & Families for EXOC3 Gene

Gene Families for EXOC3 Gene

Protein Domains for EXOC3 Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for EXOC3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

O60645

UniProtKB/Swiss-Prot:

EXOC3_HUMAN :
  • Belongs to the SEC6 family.
Family:
  • Belongs to the SEC6 family.
genes like me logo Genes that share domains with EXOC3: view

Function for EXOC3 Gene

Molecular function for EXOC3 Gene

UniProtKB/Swiss-Prot Function:
Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane

Gene Ontology (GO) - Molecular Function for EXOC3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000149 SNARE binding IBA --
GO:0005515 protein binding IPI 18329369
genes like me logo Genes that share ontologies with EXOC3: view

Phenotypes for EXOC3 Gene

genes like me logo Genes that share phenotypes with EXOC3: view

Animal Model Products

CRISPR Products

miRNA for EXOC3 Gene

miRTarBase miRNAs that target EXOC3

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for EXOC3

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targets and HOMER Transcription for EXOC3 Gene

Localization for EXOC3 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for EXOC3 Gene COMPARTMENTS Subcellular localization image for EXOC3 gene
Compartment Confidence
cytosol 4
golgi apparatus 2
mitochondrion 2
nucleus 2
plasma membrane 2
cytoskeleton 1
endosome 1
vacuole 1

Gene Ontology (GO) - Cellular Components for EXOC3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000145 exocyst IBA --
GO:0005829 cytosol TAS --
GO:0030667 secretory granule membrane TAS --
genes like me logo Genes that share ontologies with EXOC3: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for EXOC3 Gene

Pathways & Interactions for EXOC3 Gene

genes like me logo Genes that share pathways with EXOC3: view

Pathways by source for EXOC3 Gene

Gene Ontology (GO) - Biological Process for EXOC3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006887 exocytosis IBA --
GO:0006996 organelle organization TAS --
GO:0015031 protein transport IEA --
GO:0044267 cellular protein metabolic process TAS --
GO:0051601 exocyst localization IBA --
genes like me logo Genes that share ontologies with EXOC3: view

No data available for SIGNOR curated interactions for EXOC3 Gene

Drugs & Compounds for EXOC3 Gene

No Compound Related Data Available

Transcripts for EXOC3 Gene

Unigene Clusters for EXOC3 Gene

Exocyst complex component 3:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for EXOC3

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for EXOC3 Gene

No ASD Table

Relevant External Links for EXOC3 Gene

GeneLoc Exon Structure for
EXOC3
ECgene alternative splicing isoforms for
EXOC3

Expression for EXOC3 Gene

mRNA expression in normal human tissues for EXOC3 Gene

Protein differential expression in normal tissues from HIPED for EXOC3 Gene

This gene is overexpressed in Bone (19.4) and Brain (6.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for EXOC3 Gene



SOURCE GeneReport for Unigene cluster for EXOC3 Gene Hs.481464

mRNA Expression by UniProt/SwissProt for EXOC3 Gene

O60645-EXOC3_HUMAN
Tissue specificity: Expressed in epididymis (at protein level).
genes like me logo Genes that share expression patterns with EXOC3: view

Protein tissue co-expression partners for EXOC3 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for EXOC3 Gene

Orthologs for EXOC3 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for EXOC3 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia EXOC3 35
  • 86.49 (n)
  • 93.29 (a)
EXOC3 36
  • 93 (a)
OneToOne
dog
(Canis familiaris)
Mammalia EXOC3 35
  • 88.32 (n)
  • 93.83 (a)
-- 36
  • 64 (a)
OneToMany
-- 36
  • 94 (a)
OneToMany
mouse
(Mus musculus)
Mammalia Exoc3 35
  • 86.8 (n)
  • 96.24 (a)
Exoc3 16
Exoc3 36
  • 95 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia EXOC3 35
  • 99.69 (n)
  • 99.6 (a)
EXOC3 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Exoc3 35
  • 86.4 (n)
  • 94.9 (a)
oppossum
(Monodelphis domestica)
Mammalia EXOC3 36
  • 89 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia EXOC3 36
  • 86 (a)
OneToOne
chicken
(Gallus gallus)
Aves EXOC3 35
  • 75.75 (n)
  • 85.77 (a)
EXOC3 36
  • 86 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia EXOC3 36
  • 76 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia exoc3 35
  • 71.19 (n)
  • 79.44 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.24117 35
zebrafish
(Danio rerio)
Actinopterygii Dr.7300 35
exoc3 35
  • 73.04 (n)
  • 75.88 (a)
exoc3 36
  • 75 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP009058 35
  • 51.48 (n)
  • 38.89 (a)
fruit fly
(Drosophila melanogaster)
Insecta sec6 35
  • 50.46 (n)
  • 39.12 (a)
sec6 36
  • 38 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea sec-6 35
  • 45.07 (n)
  • 34.49 (a)
sec-6 36
  • 30 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes SEC6 38
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 47 (a)
OneToMany
Species with no ortholog for EXOC3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for EXOC3 Gene

ENSEMBL:
Gene Tree for EXOC3 (if available)
TreeFam:
Gene Tree for EXOC3 (if available)

Paralogs for EXOC3 Gene

Paralogs for EXOC3 Gene

(3) SIMAP similar genes for EXOC3 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with EXOC3: view

Variants for EXOC3 Gene

Structural Variations from Database of Genomic Variants (DGV) for EXOC3 Gene

Variant ID Type Subtype PubMed ID
dgv1733e1 CNV Complex 17122850
nsv880815 CNV Loss 21882294
nsv880786 CNV Loss 21882294
nsv830183 CNV Gain+Loss 17160897
nsv830184 CNV Gain 17160897
esv2752071 CNV Gain 17911159
dgv5880n71 CNV Loss 21882294
nsv880597 CNV Gain 21882294
nsv881301 CNV Gain 21882294
dgv5881n71 CNV Gain 21882294
dgv5882n71 CNV Loss 21882294
nsv880710 CNV Loss 21882294
nsv880617 CNV Loss 21882294
nsv4673 CNV Insertion 18451855
nsv881627 CNV Loss 21882294
nsv461889 CNV Gain 19166990
nsv881561 CNV Gain 21882294
nsv461890 CNV Gain 19166990
dgv5883n71 CNV Gain 21882294
dgv5884n71 CNV Gain 21882294
nsv4674 CNV Insertion 18451855
nsv527666 CNV Loss 19592680
dgv5885n71 CNV Loss 21882294
dgv5886n71 CNV Loss 21882294
dgv5887n71 CNV Loss 21882294
nsv881305 CNV Loss 21882294
nsv10647 CNV Gain 18304495
nsv513205 CNV Loss 21212237
esv2547373 CNV Deletion 19546169
esv1945211 CNV Deletion 18987734

Variation tolerance for EXOC3 Gene

Residual Variation Intolerance Score: 15.26% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.85; 34.72% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for EXOC3 Gene

HapMap Linkage Disequilibrium report
EXOC3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations from dbSNP and Humsavar for EXOC3 Gene

Disorders for EXOC3 Gene

Relevant External Links for EXOC3

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
EXOC3
genes like me logo Genes that share disorders with EXOC3: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for EXOC3 Gene

Publications for EXOC3 Gene

  1. A "double adaptor" method for improved shotgun library construction. (PMID: 8619474) Andersson B. … Gibbs R.A. (Anal. Biochem. 1996) 2 67
  2. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 67
  3. Temporal proteomics of NGF-TrkA signaling identifies an inhibitory role for the E3 ligase Cbl-b in neuroblastoma cell differentiation. (PMID: 25921289) Emdal K.B. … Olsen J.V. (Sci Signal 2015) 67
  4. Panorama of ancient metazoan macromolecular complexes. (PMID: 26344197) Wan C. … Emili A. (Nature 2015) 67
  5. N-terminome analysis of the human mitochondrial proteome. (PMID: 25944712) Vaca Jacome A.S. … Carapito C. (Proteomics 2015) 67

Products for EXOC3 Gene

Sources for EXOC3 Gene

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