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Aliases for EXOC3 Gene

Aliases for EXOC3 Gene

  • Exocyst Complex Component 3 2 3 5
  • Exocyst Complex Component Sec6 3 4
  • SEC6L1 3 4
  • SEC6 3 4
  • SEC6-Like 1 (S. Cerevisiae) 2
  • Sec 6 Homolog 3
  • SEC6-Like 1 3
  • Sec6p 3

External Ids for EXOC3 Gene

Previous HGNC Symbols for EXOC3 Gene

  • SEC6L1

Previous GeneCards Identifiers for EXOC3 Gene

  • GC05P000497

Summaries for EXOC3 Gene

Entrez Gene Summary for EXOC3 Gene

  • The protein encoded by this gene is a component of the exocyst complex, a multiple protein complex essential for targeting exocytic vesicles to specific docking sites on the plasma membrane. Though best characterized in yeast, the component proteins and functions of exocyst complex have been demonstrated to be highly conserved in higher eukaryotes. At least eight components of the exocyst complex, including this protein, are found to interact with the actin cytoskeletal remodeling and vesicle transport machinery. The complex is also essential for the biogenesis of epithelial cell surface polarity. [provided by RefSeq, Jul 2008]

GeneCards Summary for EXOC3 Gene

EXOC3 (Exocyst Complex Component 3) is a Protein Coding gene. Among its related pathways are Sertoli-Sertoli Cell Junction Dynamics and Peptide hormone metabolism. GO annotations related to this gene include SNARE binding. An important paralog of this gene is EXOC3L1.

UniProtKB/Swiss-Prot for EXOC3 Gene

  • Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane.

Gene Wiki entry for EXOC3 Gene

Additional gene information for EXOC3 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for EXOC3 Gene

Genomics for EXOC3 Gene

Regulatory Elements for EXOC3 Gene

Enhancers for EXOC3 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH05H000413 1.8 FANTOM5 Ensembl ENCODE dbSUPER 37 -27.9 -27857 3 HDGF GLIS2 GATA2 KLF7 ATF7 SP3 SMARCB1 ZNF610 AEBP2 GLIS1 SLC9A3-AS1 EXOC3 LOC100310782 LOC100128803 MTCO2P32 EXOC3-AS1 ENSG00000250645 GC05M000414
GH05H000470 1.3 ENCODE dbSUPER 34.6 +30.0 30011 4 ARNT SIN3A ZNF2 ZNF766 ZNF207 DEK SP3 MXD4 NFYC SMARCB1 SLC9A3-AS1 EXOC3 BRD9 ENSG00000250645 EXOC3-AS1 PP7080
GH05H000424 1.4 FANTOM5 Ensembl dbSUPER 28.5 -18.5 -18457 1 HDGF MAX BACH1 EBF1 ZIC2 ZFHX2 POLR2A EED ZNF143 ATF7 EXOC3 SLC9A3-AS1 AHRR PDCD6 EXOC3-AS1 ZDHHC11 PIR58727 PIR54496 GC05M000432
GH05H000442 1 ENCODE 39 +0.2 200 2 HDGF PKNOX1 ATF1 ARNT ARID4B SIN3A DMAP1 ZNF2 YY1 GLIS2 EXOC3 EXOC3-AS1 PP7080
GH05H001117 1.8 FANTOM5 Ensembl ENCODE dbSUPER 20.8 +675.6 675580 1 PKNOX1 MLX ARID4B YY1 TCF12 GLIS2 FOS SP5 MXD4 TSHZ1 BRD9 LOC100421419 LOC100132773 EXOC3 SLC12A7 ENSG00000250173 CTD-3080P12.3 GC05P001123 LOC105374612
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around EXOC3 on UCSC Golden Path with GeneCards custom track

Promoters for EXOC3 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000177428 42 1201 HDGF PKNOX1 ARNT ARID4B SIN3A DMAP1 ZNF2 YY1 GLIS2 ELK1

Genomic Location for EXOC3 Gene

Chromosome:
5
Start:
443,158 bp from pter
End:
471,937 bp from pter
Size:
28,780 bases
Orientation:
Plus strand

Genomic View for EXOC3 Gene

Genes around EXOC3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
EXOC3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for EXOC3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for EXOC3 Gene

Proteins for EXOC3 Gene

  • Protein details for EXOC3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O60645-EXOC3_HUMAN
    Recommended name:
    Exocyst complex component 3
    Protein Accession:
    O60645
    Secondary Accessions:
    • Q6P2E8
    • Q8TEN6
    • Q8WUW0
    • Q96DI4

    Protein attributes for EXOC3 Gene

    Size:
    756 amino acids
    Molecular mass:
    86845 Da
    Quaternary structure:
    • The exocyst complex is composed of EXOC1, EXOC2, EXOC3, EXOC4, EXOC5, EXOC6, EXOC7 and EXOC8 (By similarity). Interacts with EXOC3L1 (By similarity). Interacts with BIRC6/bruce. Interacts with MYRIP (By similarity).
    SequenceCaution:
    • Sequence=BAB84912.1; Type=Frameshift; Positions=1, 563; Evidence={ECO:0000305};

    Alternative splice isoforms for EXOC3 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for EXOC3 Gene

Post-translational modifications for EXOC3 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for EXOC3 Gene

Domains & Families for EXOC3 Gene

Gene Families for EXOC3 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for EXOC3 Gene

Suggested Antigen Peptide Sequences for EXOC3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

O60645

UniProtKB/Swiss-Prot:

EXOC3_HUMAN :
  • Belongs to the SEC6 family.
Family:
  • Belongs to the SEC6 family.
genes like me logo Genes that share domains with EXOC3: view

Function for EXOC3 Gene

Molecular function for EXOC3 Gene

UniProtKB/Swiss-Prot Function:
Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane.

Phenotypes From GWAS Catalog for EXOC3 Gene

Gene Ontology (GO) - Molecular Function for EXOC3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000149 SNARE binding IBA --
GO:0005515 protein binding IPI 18329369
GO:0045296 cadherin binding IDA 25468996
genes like me logo Genes that share ontologies with EXOC3: view
genes like me logo Genes that share phenotypes with EXOC3: view

Animal Model Products

CRISPR Products

miRNA for EXOC3 Gene

miRTarBase miRNAs that target EXOC3

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for EXOC3
  • Applied Biological Materials Clones for EXOC3
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for EXOC3 Gene

Localization for EXOC3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for EXOC3 Gene

Cytoplasm. Cytoplasm, perinuclear region. Cell projection, growth cone. Midbody. Golgi apparatus. Note=Perinuclear in undifferentiated cells. Redistributes to growing neurites and growth cones during neuronal differentiation (By similarity). During mitosis, early recruitment to the midbody requires RALA, but not RALB, and EXOC2. In late stages of cytokinesis, localization to the midbody is RALB-dependent (PubMed:18756269). {ECO:0000250 UniProtKB:O54921, ECO:0000269 PubMed:18756269}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for EXOC3 gene
Compartment Confidence
cytosol 5
golgi apparatus 4
nucleus 3
plasma membrane 2
mitochondrion 2
cytoskeleton 1
peroxisome 1
endoplasmic reticulum 1
endosome 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Mitochondria (2)
  • Nucleoplasm (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for EXOC3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000145 exocyst IBA --
GO:0005737 cytoplasm IEA --
GO:0005794 Golgi apparatus IEA --
GO:0005829 cytosol TAS --
GO:0030426 growth cone IEA --
genes like me logo Genes that share ontologies with EXOC3: view

Pathways & Interactions for EXOC3 Gene

genes like me logo Genes that share pathways with EXOC3: view

Gene Ontology (GO) - Biological Process for EXOC3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006810 transport IEA --
GO:0006887 exocytosis IBA --
GO:0015031 protein transport IEA --
GO:0051601 exocyst localization IBA --
genes like me logo Genes that share ontologies with EXOC3: view

No data available for SIGNOR curated interactions for EXOC3 Gene

Drugs & Compounds for EXOC3 Gene

No Compound Related Data Available

Transcripts for EXOC3 Gene

Unigene Clusters for EXOC3 Gene

Exocyst complex component 3:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for EXOC3
  • Applied Biological Materials Clones for EXOC3
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for EXOC3 Gene

No ASD Table

Relevant External Links for EXOC3 Gene

GeneLoc Exon Structure for
EXOC3
ECgene alternative splicing isoforms for
EXOC3

Expression for EXOC3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for EXOC3 Gene

Protein differential expression in normal tissues from HIPED for EXOC3 Gene

This gene is overexpressed in Bone (19.4) and Brain (6.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for EXOC3 Gene



Protein tissue co-expression partners for EXOC3 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of EXOC3 Gene:

EXOC3

SOURCE GeneReport for Unigene cluster for EXOC3 Gene:

Hs.481464

mRNA Expression by UniProt/SwissProt for EXOC3 Gene:

O60645-EXOC3_HUMAN
Tissue specificity: Expressed in epididymis (at protein level).

Evidence on tissue expression from TISSUES for EXOC3 Gene

  • Nervous system(4.7)
  • Intestine(4.3)
  • Lung(4.3)
  • Spleen(4.3)
  • Liver(2.7)
  • Kidney(2.1)
genes like me logo Genes that share expression patterns with EXOC3: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for EXOC3 Gene

Orthologs for EXOC3 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for EXOC3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia EXOC3 33 34
  • 99.69 (n)
dog
(Canis familiaris)
Mammalia -- 34
  • 94 (a)
OneToMany
EXOC3 33
  • 88.32 (n)
-- 34
  • 64 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia EXOC3 34
  • 89 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Exoc3 33 16 34
  • 86.8 (n)
cow
(Bos Taurus)
Mammalia EXOC3 33 34
  • 86.49 (n)
rat
(Rattus norvegicus)
Mammalia Exoc3 33
  • 86.4 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia EXOC3 34
  • 86 (a)
OneToOne
chicken
(Gallus gallus)
Aves EXOC3 33 34
  • 75.75 (n)
lizard
(Anolis carolinensis)
Reptilia EXOC3 34
  • 76 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia exoc3 33
  • 71.19 (n)
African clawed frog
(Xenopus laevis)
Amphibia Xl.24117 33
zebrafish
(Danio rerio)
Actinopterygii exoc3 33 34
  • 73.04 (n)
Dr.7300 33
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP009058 33
  • 51.48 (n)
fruit fly
(Drosophila melanogaster)
Insecta sec6 33 34
  • 50.46 (n)
worm
(Caenorhabditis elegans)
Secernentea sec-6 33 34
  • 45.07 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes SEC6 36
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 47 (a)
OneToMany
Species where no ortholog for EXOC3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for EXOC3 Gene

ENSEMBL:
Gene Tree for EXOC3 (if available)
TreeFam:
Gene Tree for EXOC3 (if available)

Paralogs for EXOC3 Gene

Paralogs for EXOC3 Gene

(3) SIMAP similar genes for EXOC3 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with EXOC3: view

Variants for EXOC3 Gene

Sequence variations from dbSNP and Humsavar for EXOC3 Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type
rs1000112045 -- 449,230(+) CTTGT(C/G/T)TCATT intron-variant
rs1000301955 -- 472,069(+) GGCAG(A/G)TTTCA intron-variant, downstream-variant-500B, upstream-variant-2KB, utr-variant-3-prime
rs1000319134 -- 464,884(+) GTCCT(C/G)CTGGG intron-variant
rs1000415538 -- 465,161(+) CGGGC(C/G)GTCAT reference, synonymous-codon, utr-variant-3-prime
rs1000457984 -- 445,059(+) TCCAG(A/G)AGAAG intron-variant, upstream-variant-2KB, utr-variant-5-prime

Structural Variations from Database of Genomic Variants (DGV) for EXOC3 Gene

Variant ID Type Subtype PubMed ID
dgv9479n54 CNV gain 21841781
esv1945211 CNV deletion 18987734
esv2547373 CNV deletion 19546169
esv2752071 CNV gain 17911159
esv2759315 CNV loss 17122850
esv3603744 CNV gain 21293372
esv3603745 CNV gain 21293372
esv3603747 CNV loss 21293372
esv3603748 CNV gain 21293372
esv3894107 CNV gain 25118596
nsv1019215 CNV gain 25217958
nsv1027279 CNV gain 25217958
nsv1030767 CNV gain 25217958
nsv1032584 CNV gain 25217958
nsv1032824 CNV gain 25217958
nsv10647 CNV gain 18304495
nsv1133013 OTHER inversion 24896259
nsv1147234 OTHER inversion 26484159
nsv461889 CNV gain 19166990
nsv461890 CNV gain 19166990
nsv4673 CNV insertion 18451855
nsv4674 CNV insertion 18451855
nsv513205 CNV loss 21212237
nsv527666 CNV loss 19592680
nsv596626 CNV gain 21841781
nsv596628 CNV gain 21841781
nsv596629 CNV gain 21841781
nsv830183 CNV gain+loss 17160897
nsv830184 CNV gain 17160897

Variation tolerance for EXOC3 Gene

Residual Variation Intolerance Score: 15.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.85; 34.72% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for EXOC3 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
EXOC3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for EXOC3 Gene

Disorders for EXOC3 Gene

Relevant External Links for EXOC3

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
EXOC3

No disorders were found for EXOC3 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for EXOC3 Gene

Publications for EXOC3 Gene

  1. Systematic mapping and functional analysis of a family of human epididymal secretory sperm-located proteins. (PMID: 20736409) Li J … Liu Y (Molecular & cellular proteomics : MCP 2010) 3 4 60
  2. Final stages of cytokinesis and midbody ring formation are controlled by BRUCE. (PMID: 18329369) Pohl C … Jentsch S (Cell 2008) 3 4 60
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 60
  4. Characterization of long cDNA clones from human adult spleen. II. The complete sequences of 81 cDNA clones. (PMID: 12693554) Jikuya H … Ohara O (DNA research : an international journal for rapid publication of reports on genes and genomes 2003) 3 4 60
  5. A "double adaptor" method for improved shotgun library construction. (PMID: 8619474) Andersson B … Gibbs RA (Analytical biochemistry 1996) 2 3 60

Products for EXOC3 Gene

  • Addgene plasmids for EXOC3

Sources for EXOC3 Gene

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