Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 
or upload a file of gene symbols


Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

EXOC3 Gene

protein-coding   GIFtS: 59
GCID: GC05P000443

exocyst complex component 3

(Previous name: SEC6-like 1 (S. cerevisiae) )
(Previous symbol: SEC6L1)
 Explore 2 diseases affiliated with
EXOC3 via our new
 Human Malady Compendium 
Biological research products
for EXOC3
    

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section

Aliases
Exocyst Complex Component 31 2     SEC62 3
SEC6L11 2 3     SEC6-Like 1 (S. Cerevisiae)1
Sec6p1 2     Sec 6 Homolog2
Exocyst Complex Component Sec62 3     SEC6-Like 12

External Ids:    HGNC: 303781   Entrez Gene: 113362   Ensembl: ENSG000001801047   OMIM: 6081865   UniProtKB: O606453   

Export aliases for EXOC3 gene to outside databases

Previous GC identifer: GC05P000497


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for EXOC3:
The protein encoded by this gene is a component of the exocyst complex, a multiple protein complex essential for
targeting exocytic vesicles to specific docking sites on the plasma membrane. Though best characterized in yeast, the
component proteins and functions of exocyst complex have been demonstrated to be highly conserved in higher
eukaryotes. At least eight components of the exocyst complex, including this protein, are found to interact with the
actin cytoskeletal remodeling and vesicle transport machinery. The complex is also essential for the biogenesis of
epithelial cell surface polarity. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: EXOC3_HUMAN, O60645
Function: Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma
membrane

Gene Wiki entry for EXOC3


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000005.9  NC_018916.1  NT_006576.16  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the EXOC3 gene promoter:
         NRSF form 1   Lmo2   HNF-4alpha2   NF-kappaB   NRSF form 2   HNF-4alpha1   Egr-4   AREB6   NF-kappaB2   NF-kappaB1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidEXOC3 promoter sequence
   Search SABiosciences Chromatin IP Primers for EXOC3

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat EXOC3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 5p15.33   Ensembl cytogenetic band:  5p15.33   HGNC cytogenetic band: 5p15.33

EXOC3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
EXOC3 gene location

GeneLoc information about chromosome 5         GeneLoc Exon Structure

GeneLoc location for GC05P000443:  view genomic region     (about GC identifiers)

Start:
443,273 bp from pter      End:
472,052 bp from pter
Size:
28,780 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: EXOC3_HUMAN, O60645 (See protein sequence)
Recommended Name: Exocyst complex component 3  
Size: 756 amino acids; 86845 Da
Subunit: The exocyst complex is composed of EXOC1, EXOC2, EXOC3, EXOC4, EXOC5, EXOC6, EXOC7 and EXOC8. Interacts with
EXOC3L1 (By similarity). Interacts with BIRC6/bruce. Interacts with MYRIP (By similarity)
Sequence caution: Sequence=BAB84912.1; Type=Frameshift; Positions=1, 563;
Secondary accessions: Q6P2E8 Q8TEN6 Q8WUW0 Q96DI4
Alternative splicing: 3 isoforms:  O60645-1   O60645-2   O60645-3   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for EXOC3: NX_O60645

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_O60645

  • EXOC3 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_009208.2  
    ENSEMBL proteins: 
     ENSP00000425587   ENSP00000424404   ENSP00000422596   ENSP00000423435   ENSP00000323377  
    Reactome Protein details: O60645
    Human Recombinant Protein Products: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein: EXOC3
    OriGene Protein Over-expression Lysate: EXOC3
    OriGene Custom Protein Services for EXOC3 
    GenScript Custom Purified and Recombinant Proteins Services for EXOC3
    Novus Biologicals EXOC3 Proteins
    Novus Biologicals EXOC3 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for EXOC3

    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0030667secretory granule membrane TAS--


    EXOC3 for ontologies           About GeneDecksing



    EXOC3 Antibody Products: 
    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for EXOC3 
    GenScript Custom Superior Antibodies Services for EXOC3
    Novus Biologicals EXOC3 Antibodies
    Abcam antibodies for EXOC3 
    Uscn Antibodies for EXOC3
    ThermoFisher Antibodies for EXOC3

    Assay Products for EXOC3: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Immunoassay Development
    Browse OriGene Fluorogenic Cell Assay Kits
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for EXOC3
    Browse Enzo Life Sciences for kits & assays
    Uscn ELISAs and CLIAs for EXOC3


    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    EXOC3 for domains           About GeneDecksing

    1 InterPro domain/family:
     IPR010326 Sec6

    Graphical View of Domain Structure for InterPro Entry O60645

    ProtoNet protein and cluster: O60645

    1 Blocks protein family: IPB010326 Exocyst complex component Sec6

    UniProtKB/Swiss-Prot: EXOC3_HUMAN, O60645
    Similarity: Belongs to the SEC6 family


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section

    Function Summary:

         UniProtKB/Swiss-Prot: EXOC3_HUMAN, O60645
    Function: Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma
    membrane

    miRNA
    Products:
        
    OriGene 3'-UTR Clone: EXOC3
    Browse MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat EXOC3
    Search QIAGEN for miScript miRNA Assays for microRNAs that regulate EXOC3
    SwitchGear 3'UTR luciferase reporter plasmidEXOC3 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for EXOC3 (see all 7)
    OriGene shRNA RFP: EXOC3
    OriGene siRNA: EXOC3
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat EXOC3

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for EXOC3

    Clone
    Products:
         
    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for EXOC3 (see all 3)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for EXOC3
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector: EXOC3 (NM_007277)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for EXOC3
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat EXOC3 

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for EXOC3
    Search LifeMap BioReagents cell lines for EXOC3

    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for EXOC3

    Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI18329369


    EXOC3 for ontologies           About GeneDecksing



    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways - 5/9 super-pathways (see all 9About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Insulin Processing
    Insulin Processing1.00
    Peptide hormone metabolism0.39
    2Exocyst complex formation
    Exocyst complex formation1.00
    Translocation of GLUT4 Vesicle and Docking at the Plasma Membrane0.50
    3Membrane Trafficking
    Membrane Trafficking1.00
    Translocation of GLUT4 to the Plasma Membrane0.32
    4Cytoskeleton remodeling_RalB regulation pathway
    Cytoskeleton remodeling RalA regulation pathway0.23
    Cytoskeleton remodeling_RalA regulation pathway0.23
    5Insulin Pathway
    Insulin Pathway1.00

    Pathway sources
    See GeneCards unified pathways
    Show all pathways

    1 EMD Millipore Pathway for EXOC3
        Cytoskeleton remodeling RalA regulation pathway


    1 GeneGo (Thomson Reuters) Pathway for EXOC3
        Cytoskeleton remodeling RalA regulation pathway

    3 BioSystems Pathways for EXOC3 
        Stabilization and expansion of the E-cadherin adherens junction
    Insulin Pathway
    Arf6 trafficking events

    5/7        Reactome Pathways for EXOC3 (see all 7)
        Exocyst complex formation
    Membrane Trafficking
    Insulin Processing
    Metabolism of proteins
    Translocation of GLUT4 to the Plasma Membrane


    1         Kegg Pathway  (Kegg details for EXOC3):
        Tight junction


    EXOC3 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for EXOC3

    STRING Interaction Network Preview (showing 5 interactants - click image to see 24)

    5/584 Interacting proteins for EXOC3 (O606452, 3 ENSP000003233774) via UniProtKB, MINT, STRING, and/or I2D (see all 584)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    EXOC4Q96A652, 3, ENSP000002538614MINT-7945693 I2D: score=6 STRING: ENSP00000253861
    EXOC2Q96KP12, 3, ENSP000002304494MINT-7945693 I2D: score=4 STRING: ENSP00000230449
    EXOC5O004712, 3, ENSP000003899344MINT-7945693 I2D: score=1 STRING: ENSP00000389934
    MLH1P406922, 3MINT-7945693 I2D: score=1 
    RALAP112333, ENSP000000052574I2D: score=2 STRING: ENSP00000005257
    About this table

    Gene Ontology (GO): 2 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006887exocytosis IEA--
    GO:0015031protein transport IEA--


    EXOC3 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for EXOC3
    Search CenterWatch for drugs/clinical trials and news about EXOC3 

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for EXOC3 gene: 
    NM_007277.4  

    Unigene Cluster for EXOC3:

    Exocyst complex component 3
    Hs.481464  [show with all ESTs]
    Unigene Representative Sequence: AK074086
    10 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000512944(uc003jba.3) ENST00000510441 ENST00000515601 ENST00000508022
    ENST00000503889(uc003jbb.1) ENST00000510028 ENST00000511015 ENST00000505947
    ENST00000509294 ENST00000315013

    miRNA
    Products:
         
    OriGene 3'-UTR Clone: EXOC3
    Browse OriGene MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat EXOC3
    Search QIAGEN for miScript miRNA Assays for microRNAs that regulate EXOC3
    SwitchGear 3'UTR luciferase reporter plasmidEXOC3 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for EXOC3 (see all 7)
    OriGene shRNA RFP: EXOC3
    OriGene siRNA: EXOC3
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat EXOC3
    Clone
    Products:
         
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for EXOC3 (see all 3)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for EXOC3
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector: EXOC3 (NM_007277)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for EXOC3
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat EXOC3 
    Primer
    Products:
        
    OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for EXOC3
    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat EXOC3
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat EXOC3
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat EXOC3

    Additional cDNA sequence: 

    AF055006.1 AK074086.1 AK131103.1 AK315749.1 AL832434.1 BC001511.2 BC019304.1 BC034427.1 
    BC064569.1 GU727644.1 

    15 DOTS entries:

    DT.316256  DT.91751558  DT.101986504  DT.95314348  DT.91749498  DT.99991192  DT.100833670  DT.217806 
    DT.95363269  DT.40113952  DT.91902262  DT.97784647  DT.120838752  DT.120838768  DT.91740092 

    24/332 AceView cDNA sequences (see all 332):

    BE728469 BE304432 BQ717495 BQ447419 CB139147 CB147127 BE206746 F08274 
    AI754911 AI468394 BE740276 BQ227566 AW628017 CB146659 AL832434 CB242047 
    CB148372 BM785563 F08044 BF725792 BM796205 CB121423 CB130057 BU070992 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    EXOC3 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: GAGACCCTGG

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)

    About this image
    See EXOC3 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for EXOC3

    SOURCE GeneReport for Unigene cluster: Hs.481464

    UniProtKB/Swiss-Prot: EXOC3_HUMAN, O60645
    Tissue specificity: Expressed in epididymis (at protein level)

        SABiosciences Custom PCR Arrays for EXOC3
    Primer
    Products:
    OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for EXOC3
    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat EXOC3
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat EXOC3
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat EXOC3
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for EXOC3

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for EXOC3 gene from 9/26 species (see all 26)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Exoc31 , 5 exocyst complex component 31, 5 86.8(n)1
    96.24(a)1
      13 (40.15 cM)5
    2114461  NM_177333.31  NP_796307.21 
     741698055 
    chicken
    (Gallus gallus)
    Aves EXOC31 exocyst complex component 3 75.75(n)
    85.77(a)
      420987  NM_001006384.1  NP_001006384.1 
    lizard
    (Anolis carolinensis)
    Reptilia EXOC36
    --
    81(a)
    1 ↔ 1
    6(54770199-54791589)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.241172 Xenopus laevis transcribed sequence with weak similarity more 78.57(n)    CB180360.1 
    zebrafish
    (Danio rerio)
    Actinopterygii Dr.73002 Danio rerio cDNA clone MGC55709 IMAGE3815932, complete more 77.22(n)    BC045435.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta sec61 CG5341-PA 50.46(n)
    39.12(a)
      37142  NM_137507.3  NP_611351.1 
    worm
    (Caenorhabditis elegans)
    Secernentea sec-61 Protein SEC-6 44.7(n)
    34.1(a)
      173910  NM_062605.6  NP_495006.2 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes SEC6(YIL068C)4
    SEC61
    Essential 88kDa subunit of the exocyst complex, which more4
    Sec6p1
    38.45(n)1
    24.59(a)1
      9(235474-233057)4
    8547421, 4  NP_012196.11, 4 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons SEC61 protein SEC6 37.09(n)
    21.47(a)
      843512  NM_105840.3  NP_565026.1 


    ENSEMBL Gene Tree for EXOC3 (if available)
    TreeFam Gene Tree for EXOC3 (if available) 

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for EXOC3 gene
    EXOC3L22  TNFAIP22  EXOC3L12  EXOC3L42  
    3 SIMAP similar genes for EXOC3 using alignment to 4 protein entries:     EXOC3_HUMAN (see all proteins):
    DKFZp762K123    FLJ00339    EXOC3L1

    EXOC3 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/569 NCBI SNPs in EXOC3 are shown (see all 569    About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 5 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs3495811,2
    --441350(-) gagatA/Ggcacc 2 -- ds5001 us2k10--------
    rs27210391,2
    --441464(-) aaaaaA/Ccccac 2 -- ds5001 us2k10--------
    rs131659931,2
    C--441544(+) ggggtC/Ttgccc 2 -- us2k1 ds50011Minor allele frequency- T:0.50NA 2
    rs1386411171,2
    --441547(+) GTCTG-/CCCATC
    TCAGCCTCC
    CAAAG
    2 -- ds5001 us2k10--------
    rs119514531,2
    C,A,H--441590(+) gagccA/Cctgcg 2 -- us2k1 ds50010--------
    rs27210381,2
    C,F,H,--441594(-) TGGGCA/GCAGTG 2 -- us2k1 ds50019Minor allele frequency- G:0.46NA CSA WA EA 369
    rs27210371,2
    C,--441610(-) AAAGGG/TATTTA 2 -- ds5001 us2k14Minor allele frequency- T:0.12WA NA 8
    rs709552451,2
    C--441613(-) AAAAAAAAAAA  
      AAAA
    /-
    AAAAA
    2 -- us2k1 ut311Minor allele frequency- -:0.00NA 2
    rs1931453391,2
    --441682(+) AGTACA/GGTGGC 2 -- ut31 us2k10--------
    rs121530911,2
    C,--441695(+) gatctC/Tggctc 2 -- us2k1 ut311Minor allele frequency- T:0.50NA 2

    HapMap Linkage Disequilibrium report for EXOC3 (443273 - 472052 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 5 variations for EXOC3
         5 CNVs: 3536 99030 8476 4427 4228

    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing EXOC3
    DNA2.0 Custom Variant and Variant Library Synthesis for EXOC3

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    EXOC3 for disorders           About GeneDecksing

    OMIM gene information: 608186    OMIM disorders: --

    2 diseases for EXOC3:    About MalaCards
    stomatitis    epididymitis


    Export disorders for EXOC3 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for EXOC3 gene, integrated from 9 sources (see all 27):
    (articles sorted by number of sources associating them with EXOC3)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Systematic mapping and functional analysis of a family of human epididymal secretory sperm-located proteins. (PubMed id 20736409)1, 2 Li J.... Liu Y. (2010)
    2. Final stages of cytokinesis and midbody ring formation are controlled by BRUCE. (PubMed id 18329369)1, 2 Pohl C. and Jentsch S. (2008)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    4. Characterization of long cDNA clones from human adult spleen. II. The complete sequences of 81 cDNA clones. (PubMed id 12693554)1, 2 Jikuya H....Ohara O. (2003)
    5. A "double adaptor" method for improved shotgun library construction. (PubMed id 8619474)1, 3 Andersson B.... Gibbs R.A. (1996)
    6. Knockdown of Sec6 improves cell-cell adhesion by incre asing a-E-catenin in oral cancer cells. (PubMed id 22381337)1 Tanaka T....Goto K. (2012)
    7. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (2012)
    8. Proteomic analysis of HIV-1 Nef cellular binding partn ers reveals a role for exocyst complex proteins in mediating enhancement of inte rcellular nanotube formation. (PubMed id 22534017)1 Mukerji J....Gabuzda D. (2012)
    9. Myosin V transports secretory vesicles via a Rab GTPas e cascade and interaction with the exocyst complex. (PubMed id 22172676)1 Jin Y....Weisman L.S. (2011)
    10. Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 11336 HGNC: 30378 AceView: SEC6L1 Ensembl:ENSG00000180104 euGenes: HUgn11336
    ECgene: EXOC3 Kegg: 11336 H-InvDB: EXOC3

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for EXOC3 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for EXOC3 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for EXOC3 gene:
    Search GeneIP for patents involving EXOC3

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences),
    In Situ Hybridization Assays from
    Advanced Cell Diagnostics
    About This Section

     
     EMD Millipore Custom Antibody & Bulk Services
     EMD Millipore Preclinical / Clinical Development Services
     EMD Millipore Immunoassay Services
     EMD Millipore Target Screening & Profiling Services

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
     Browse ELISpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Multiplex/Array Assay Kits/Reagents  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Phosphatase Activity Assays/Reagents   Browse Recombinant/Natural Proteins  
     Browse OriGene Antibodies   OriGene shRNA RFP for EXOC3  
     OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for EXOC3   OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for EXOC3  
     OriGene Protein Over-expression Lysate for EXOC3   Browse OriGene Fluorogenic Cell Assay Kits  
     OriGene siRNA for EXOC3   OriGene 3'-UTR Clone for EXOC3  
     OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for EXOC3   OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for EXOC3  
     Browse OriGene GFP tagged cDNA clones in CMV expression vector   Browse OriGene MicroRNA Expression Plasmids  
     Browse OriGene basic RS shRNAs   Browse OriGene validated miRNA SYBR primer pairs  
     OriGene Purified Protein for EXOC3   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for EXOC3   OriGene Custom Protein Services for EXOC3  
     OriGene Custom Immunoassay Development  

     
     
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat EXOC3
     QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing EXOC3
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat EXOC3
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat EXOC3
     QIAGEN QuantiFast Probe-based Assays in human, mouse, rat EXOC3
     QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat EXOC3
     GenScript Custom Purified and Recombinant Proteins Services for EXOC3 GenScript cDNA clones with any tag delivered in your preferred vector for EXOC3
     GenScript Custom Assay Services for EXOC3 GenScript Custom Superior Antibodies Services for EXOC3
     GenScript Custom overexpressing Cell Line Services for EXOC3 CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Search for Antibodies & Assays

     Regulatory tfbs in EXOC3 promoter
     Search Chromatin IP Primers for EXOC3
     RT2 qPCR Primer Assay in human, mouse, rat EXOC3
     GNC Network for EXOC3
     SABiosciences Custom PCR Arrays for EXOC3
     Search Tocris compounds for EXOC3
     Browse Sino Biological Proteins and Antibodies
     Browse Sino Biological cDNA Clones
     Antibodies/Proteins Production Services
     Rabbit Monoclonal Antibody Platform
     Bulk Purchasing
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     EXOC3 antibodies
     EXOC3 proteins
     EXOC3 lysates
     Antibodies for EXOC3
     See all of Abcam's Antibodies, Kits and Proteins for EXOC3
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins




     EXOC3 Proteins, Antibodies, CLIAs, and ELISAs
     Search LifeMap BioReagents cell lines for EXOC3
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for EXOC3
     SwitchGear 3'UTR luciferase reporter plasmids for EXOC3
     SwitchGear Promoter luciferase reporter plasmids for EXOC3
     ThermoFisher Antibodies for EXOC3
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat EXOC3
           
    GeneCards Homepage - Last full update: 18 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 27 Apr 2013

    View Random Gene

    Category
    VWF
    (GIFTS: 73)
    von Willebrand factor
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      EXOC3 gene at Home site.
    hostname: 356980-web2.xennexinc.com index build: 100 solr: 1.4