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Aliases for EXOC2 Gene

Aliases for EXOC2 Gene

  • Exocyst Complex Component 2 2 3 5
  • Exocyst Complex Component Sec5 3 4
  • SEC5L1 3 4
  • SEC5 3 4
  • SEC5-Like 1 (S. Cerevisiae) 2
  • SEC5-Like 1 3
  • Sec5p 3

External Ids for EXOC2 Gene

Previous HGNC Symbols for EXOC2 Gene

  • SEC5L1

Previous GeneCards Identifiers for EXOC2 Gene

  • GC06M000431

Summaries for EXOC2 Gene

Entrez Gene Summary for EXOC2 Gene

  • The protein encoded by this gene is a component of the exocyst complex, a multi-protein complex essential for the polarized targeting of exocytic vesicles to specific docking sites on the plasma membrane. Though best characterized in yeast, the component proteins and the functions of the exocyst complex have been demonstrated to be highly conserved in higher eukaryotes. At least eight components of the exocyst complex, including this protein, are found to interact with the actin cytoskeletal remodeling and vesicle transport machinery. This interaction has been shown to mediate filopodia formation in fibroblasts. This protein has been shown to interact with the Ral subfamily of GTPases and thereby mediate exocytosis by tethering vesicles to the plasma membrane. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2012]

GeneCards Summary for EXOC2 Gene

EXOC2 (Exocyst Complex Component 2) is a Protein Coding gene. Among its related pathways are Remodeling of Adherens Junctions and Translocation of GLUT4 to the plasma membrane. GO annotations related to this gene include protein kinase binding and Ral GTPase binding.

UniProtKB/Swiss-Prot for EXOC2 Gene

  • Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane.

Gene Wiki entry for EXOC2 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for EXOC2 Gene

Genomics for EXOC2 Gene

Regulatory Elements for EXOC2 Gene

Enhancers for EXOC2 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around EXOC2 on UCSC Golden Path with GeneCards custom track

Promoters for EXOC2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around EXOC2 on UCSC Golden Path with GeneCards custom track

Genomic Location for EXOC2 Gene

485,133 bp from pter
693,141 bp from pter
208,009 bases
Minus strand

Genomic View for EXOC2 Gene

Genes around EXOC2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
EXOC2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for EXOC2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for EXOC2 Gene

Proteins for EXOC2 Gene

  • Protein details for EXOC2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Exocyst complex component 2
    Protein Accession:
    Secondary Accessions:
    • B2RBE6
    • Q5JPC8
    • Q96AN6
    • Q9NUZ8
    • Q9UJM7

    Protein attributes for EXOC2 Gene

    924 amino acids
    Molecular mass:
    104066 Da
    Quaternary structure:
    • The exocyst complex is composed of EXOC1, EXOC2, EXOC3, EXOC4, EXOC5, EXOC6, EXOC7 and EXOC8. Interacts with EXOC3L1 (By similarity). Interacts with RALA and GNEFR/DELGEF. Interaction with GNEFR occurs only in the presence of magnesium or manganese and is stimulated by dCTP or GTP. Interacts with RALB.
    • Sequence=BAA91963.1; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for EXOC2 Gene

Proteomics data for EXOC2 Gene at MOPED

Post-translational modifications for EXOC2 Gene

  • Ubiquitination at Lys 206, Lys 281, Lys 296, and Lys 902
  • Modification sites at PhosphoSitePlus

Other Protein References for EXOC2 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for EXOC2 Gene

Domains & Families for EXOC2 Gene

Gene Families for EXOC2 Gene

Protein Domains for EXOC2 Gene

Suggested Antigen Peptide Sequences for EXOC2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Interacts with RALA through the TIG domain.
  • Belongs to the SEC5 family.
  • Interacts with RALA through the TIG domain.
  • Contains 1 IPT/TIG domain.
  • Belongs to the SEC5 family.
genes like me logo Genes that share domains with EXOC2: view

Function for EXOC2 Gene

Molecular function for EXOC2 Gene

UniProtKB/Swiss-Prot Function:
Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane.

Gene Ontology (GO) - Molecular Function for EXOC2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0047485 protein N-terminus binding IEA --
genes like me logo Genes that share ontologies with EXOC2: view
genes like me logo Genes that share phenotypes with EXOC2: view

Animal Model Products

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for EXOC2 Gene

Localization for EXOC2 Gene

Subcellular locations from

Jensen Localization Image for EXOC2 Gene COMPARTMENTS Subcellular localization image for EXOC2 gene
Compartment Confidence
cytosol 5
plasma membrane 5
golgi apparatus 2
cytoskeleton 1
endosome 1
mitochondrion 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for EXOC2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000145 exocyst IDA 24056301
genes like me logo Genes that share ontologies with EXOC2: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for EXOC2 Gene

Pathways & Interactions for EXOC2 Gene

genes like me logo Genes that share pathways with EXOC2: view

Gene Ontology (GO) - Biological Process for EXOC2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001927 exocyst assembly IBA --
GO:0006996 organelle organization TAS --
genes like me logo Genes that share ontologies with EXOC2: view

No data available for SIGNOR curated interactions for EXOC2 Gene

Drugs & Compounds for EXOC2 Gene

(3) Drugs for EXOC2 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Guanosine triphosphate Experimental Pharma 0
Manganese Pharma 32
Magnesium Nutra 0
genes like me logo Genes that share compounds with EXOC2: view

Transcripts for EXOC2 Gene

mRNA/cDNA for EXOC2 Gene

Unigene Clusters for EXOC2 Gene

Exocyst complex component 2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for EXOC2 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^ 20 ^ 21 ^ 22 ^ 23 ^ 24 ^ 25 ^ 26 ^
SP1: -

ExUns: 27 ^ 28 ^ 29 ^ 30a · 30b ^ 31 ^ 32a · 32b ^ 33
SP1: - -
SP2: - - -

Relevant External Links for EXOC2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for EXOC2 Gene

mRNA expression in normal human tissues for EXOC2 Gene

Protein differential expression in normal tissues from HIPED for EXOC2 Gene

This gene is overexpressed in Bone (8.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for EXOC2 Gene

SOURCE GeneReport for Unigene cluster for EXOC2 Gene Hs.484412

mRNA Expression by UniProt/SwissProt for EXOC2 Gene

Tissue specificity: Widely expressed with highest levels in brain and placenta.
genes like me logo Genes that share expression patterns with EXOC2: view

Protein tissue co-expression partners for EXOC2 Gene

- Elite partner

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for EXOC2 Gene

Orthologs for EXOC2 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for EXOC2 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia EXOC2 35
  • 85.14 (n)
  • 90.8 (a)
EXOC2 36
  • 91 (a)
(Canis familiaris)
Mammalia EXOC2 35
  • 88.85 (n)
  • 95.56 (a)
EXOC2 36
  • 96 (a)
(Mus musculus)
Mammalia Exoc2 35
  • 87.3 (n)
  • 93.61 (a)
Exoc2 16
Exoc2 36
  • 94 (a)
(Pan troglodytes)
Mammalia EXOC2 35
  • 99.42 (n)
  • 99.78 (a)
EXOC2 36
  • 100 (a)
(Rattus norvegicus)
Mammalia Exoc2 35
  • 87.27 (n)
  • 94.16 (a)
(Monodelphis domestica)
Mammalia EXOC2 36
  • 89 (a)
(Ornithorhynchus anatinus)
Mammalia EXOC2 36
  • 92 (a)
(Gallus gallus)
Aves EXOC2 35
  • 80.09 (n)
  • 89.83 (a)
EXOC2 36
  • 90 (a)
(Anolis carolinensis)
Reptilia EXOC2 36
  • 86 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia exoc2 35
  • 73.95 (n)
  • 80.52 (a)
Str.10084 35
(Danio rerio)
Actinopterygii exoc2 35
  • 70.66 (n)
  • 77.91 (a)
zgc63558 35
exoc2 36
  • 77 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.4905 35
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP001733 35
  • 46.27 (n)
  • 38.22 (a)
fruit fly
(Drosophila melanogaster)
Insecta sec5 35
  • 46.06 (n)
  • 36.65 (a)
sec5 36
  • 35 (a)
(Caenorhabditis elegans)
Secernentea sec-5 35
  • 44.65 (n)
  • 29.82 (a)
sec-5 36
  • 28 (a)
thale cress
(Arabidopsis thaliana)
eudicotyledons SEC5A 35
  • 41.16 (n)
  • 26.59 (a)
(Oryza sativa)
Liliopsida Os04g0421900 35
  • 41.47 (n)
  • 24.26 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.12002 35
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 50 (a)
Species with no ortholog for EXOC2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for EXOC2 Gene

Gene Tree for EXOC2 (if available)
Gene Tree for EXOC2 (if available)

Paralogs for EXOC2 Gene

No data available for Paralogs for EXOC2 Gene

Variants for EXOC2 Gene

Sequence variations from dbSNP and Humsavar for EXOC2 Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type
rs35600069 - 617,788(+) TCTTG(C/G/T)TAGCC nc-transcript-variant, reference, missense
rs1008784 -- 574,044(-) CTTAC(G/T)TTTGA intron-variant
rs1018413 -- 557,284(+) AAAGT(A/T)TAGAA intron-variant
rs1033477 -- 619,181(+) CTGCA(C/T)CAATA intron-variant
rs1099772 -- 645,892(+) tacca(C/G)taagg intron-variant

Structural Variations from Database of Genomic Variants (DGV) for EXOC2 Gene

Variant ID Type Subtype PubMed ID
dgv1886e1 CNV Complex 17122850
nsv428134 CNV Gain 18775914
esv581 CNV CNV 17122850
dgv1887e1 CNV Complex 17122850
nsv883359 CNV Gain 21882294
dgv1897e1 CNV Complex 17122850
nsv830569 CNV Gain 17160897
nsv5167 CNV Loss 18451855
nsv819424 CNV Loss 19587683
esv1476529 CNV Deletion 17803354
esv1708635 CNV Insertion 17803354
esv2731355 CNV Deletion 23290073
esv2731356 CNV Deletion 23290073
esv990956 CNV Insertion 20482838
esv28427 CNV Gain+Loss 19812545
esv2731357 CNV Deletion 23290073
nsv521248 CNV Loss 19592680
nsv528164 CNV Loss 19592680
nsv820738 CNV Deletion 20802225
nsv513288 CNV Loss 21212237
esv1288084 CNV Deletion 17803354
esv1209367 CNV Insertion 17803354
nsv522827 CNV Loss 19592680
esv2731358 CNV Deletion 23290073
essv22330 CNV CNV 17122850
nsv462609 CNV Gain 19166990
nsv5168 CNV Loss 18451855
nsv883361 CNV Gain 21882294
esv2670771 CNV Deletion 23128226
esv25398 CNV Loss 19812545
esv2731359 CNV Deletion 23290073
esv21609 CNV Loss 19812545
nsv513289 CNV Loss 21212237
esv2548242 CNV Deletion 19546169
nsv349892 CNV Loss 16902084
esv2731360 CNV Deletion 23290073
esv1333120 CNV Deletion 17803354
esv2731363 CNV Deletion 23290073
esv2731364 CNV Deletion 23290073
esv2731365 CNV Deletion 23290073
esv2731366 CNV Deletion 23290073
esv2731367 CNV Deletion 23290073
nsv5169 CNV Loss 18451855
esv995480 CNV Deletion 20482838
esv2575838 CNV Deletion 19546169
nsv513290 CNV Loss 21212237
esv2052896 CNV Deletion 18987734
esv2806 CNV Deletion 18987735
esv2731368 CNV Deletion 23290073
nsv514341 CNV Loss 21397061
esv8276 CNV Loss 19470904
esv26846 CNV Loss 19812545
nsv513291 CNV Loss 21212237
esv2558058 CNV Deletion 19546169
esv2134988 CNV Deletion 18987734
esv27485 CNV Loss 19812545
esv2731369 CNV Deletion 23290073
nsv348666 CNV Loss 16902084
esv1399069 CNV Deletion 17803354
nsv349641 CNV Loss 16902084
esv2743266 CNV Deletion 23290073
esv1416044 CNV Deletion 17803354
esv1502705 CNV Deletion 17803354
esv2731370 CNV Deletion 23290073
esv2132988 CNV Deletion 18987734
esv1623218 CNV Insertion 17803354
esv1105432 CNV Deletion 17803354
esv2731371 CNV Deletion 23290073
nsv830571 CNV Loss 17160897

Variation tolerance for EXOC2 Gene

Residual Variation Intolerance Score: 3.34% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.45; 43.17% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for EXOC2 Gene

Disorders for EXOC2 Gene

Relevant External Links for EXOC2

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for EXOC2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for EXOC2 Gene

Publications for EXOC2 Gene

  1. DelGEF, a homologue of the Ran guanine nucleotide exchange factor RanGEF, binds to the exocyst component Sec5 and modulates secretion. (PMID: 12459492) Sjoelinder M. … Ponstingl H. (FEBS Lett. 2002) 2 3 4 23 67
  2. Ral-regulated interaction between Sec5 and paxillin targets Exocyst to focal complexes during cell migration. (PMID: 18697830) Spiczka K.S. … Yeaman C. (J. Cell. Sci. 2008) 3 23
  3. Mutations in the exocyst component Sec5 disrupt neuronal membrane traffic, but neurotransmitter release persists. (PMID: 12575951) Murthy M. … Schwarz T.L. (Neuron 2003) 2 3
  4. Structure of the GTPase-binding domain of Sec5 and elucidation of its Ral binding site. (PMID: 12624092) Mott H.R. … Owen D. (J. Biol. Chem. 2003) 3 23
  5. Temporal proteomics of NGF-TrkA signaling identifies an inhibitory role for the E3 ligase Cbl-b in neuroblastoma cell differentiation. (PMID: 25921289) Emdal K.B. … Olsen J.V. (Sci Signal 2015) 3

Products for EXOC2 Gene

Sources for EXOC2 Gene