Aliases for EXOC2 Gene
External Ids for EXOC2 Gene
Previous HGNC Symbols for EXOC2 Gene
Previous GeneCards Identifiers for EXOC2 Gene
The protein encoded by this gene is a component of the exocyst complex, a multi-protein complex essential for the polarized targeting of exocytic vesicles to specific docking sites on the plasma membrane. Though best characterized in yeast, the component proteins and the functions of the exocyst complex have been demonstrated to be highly conserved in higher eukaryotes. At least eight components of the exocyst complex, including this protein, are found to interact with the actin cytoskeletal remodeling and vesicle transport machinery. This interaction has been shown to mediate filopodia formation in fibroblasts. This protein has been shown to interact with the Ral subfamily of GTPases and thereby mediate exocytosis by tethering vesicles to the plasma membrane. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2012]
GeneCards Summary for EXOC2 Gene
EXOC2 (Exocyst Complex Component 2) is a Protein Coding gene. Among its related pathways are Remodeling of Adherens Junctions and Translocation of GLUT4 to the plasma membrane. GO annotations related to this gene include protein kinase binding and Ral GTPase binding.
UniProtKB/Swiss-Prot for EXOC2 Gene
Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane.