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Aliases for EXOC1 Gene

Aliases for EXOC1 Gene

  • Exocyst Complex Component 1 2 3 5
  • Exocyst Complex Component Sec3 3 4
  • SEC3L1 3 4
  • SEC3 3 4
  • SEC3-Like 1 (S. Cerevisiae) 2
  • SEC3-Like 1 3
  • BM-102 3
  • SEC3P 3

External Ids for EXOC1 Gene

Previous HGNC Symbols for EXOC1 Gene

  • SEC3L1

Previous GeneCards Identifiers for EXOC1 Gene

  • GC04P056561
  • GC04P056414
  • GC04P056719
  • GC04P052673

Summaries for EXOC1 Gene

Entrez Gene Summary for EXOC1 Gene

  • The protein encoded by this gene is a component of the exocyst complex, a multiple protein complex essential for targeting exocytic vesicles to specific docking sites on the plasma membrane. Though best characterized in yeast, the component proteins and functions of the exocyst complex have been demonstrated to be highly conserved in higher eukaryotes. At least eight components of the exocyst complex, including this protein, are found to interact with the actin cytoskeletal remodeling and vesicle transport machinery. Alternatively spliced transcript variants encoding distinct isoforms have been described. [provided by RefSeq, Jul 2008]

GeneCards Summary for EXOC1 Gene

EXOC1 (Exocyst Complex Component 1) is a Protein Coding gene. Diseases associated with EXOC1 include Commensal Bacterial Infectious Disease. Among its related pathways are Insulin Pathway and Cargo trafficking to the periciliary membrane. GO annotations related to this gene include phosphatidylinositol-4,5-bisphosphate binding and GTP-Rho binding. An important paralog of this gene is STXBP6.

UniProtKB/Swiss-Prot for EXOC1 Gene

  • Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane.

Gene Wiki entry for EXOC1 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for EXOC1 Gene

Genomics for EXOC1 Gene

Regulatory Elements for EXOC1 Gene

Enhancers for EXOC1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH04G055906 0.6 ENCODE 18.3 +53.4 53430 1.0 PKNOX1 JUN EP300 ZBTB40 FOSL1 JUND GATA2 STAT3 FOS IRF1 EXOC1 RNU6-652P GC04P055926
GH04G055946 1.4 ENCODE dbSUPER 6.2 +94.9 94898 4.7 HDGF PKNOX1 FOXA2 CREB3L1 AGO1 WRNIP1 ARID4B SIN3A DMAP1 ZNF2 CEP135 EXOC1 LOC105377663 GC04P055928
GH04G055864 1.1 Ensembl ENCODE 6.4 +12.6 12575 2.9 PKNOX1 FOXA2 BRCA1 RAD21 YY1 TCF12 ZNF143 FOS MIXL1 ZNF654 EXOC1 GC04M055824
GH04G055851 0.7 ENCODE 7.7 -1.6 -1568 0.9 ELF3 ZNF146 TEAD1 MXD4 MIER2 PPARG ZNF48 TEAD3 TBX3 GABPB1 EXOC1 LOC105377661
GH04G055893 0.6 ENCODE 6.8 +40.5 40514 0.5 GTF3C2 JUND POLR3A NFIB CEBPB RFX5 AASDH RN7SKP30 RPL7AP31 CEP135 EXOC1 RNU6-652P GC04P055926
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around EXOC1 on UCSC Golden Path with GeneCards custom track

Promoters for EXOC1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000168623 285 1800 HDGF PKNOX1 ARID4B SIN3A DMAP1 YY1 ZNF143 ZNF207 KLF13 SP3

Genomic Location for EXOC1 Gene

Chromosome:
4
Start:
55,853,616 bp from pter
End:
55,905,078 bp from pter
Size:
51,463 bases
Orientation:
Plus strand

Genomic View for EXOC1 Gene

Genes around EXOC1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
EXOC1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for EXOC1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for EXOC1 Gene

Proteins for EXOC1 Gene

  • Protein details for EXOC1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NV70-EXOC1_HUMAN
    Recommended name:
    Exocyst complex component 1
    Protein Accession:
    Q9NV70
    Secondary Accessions:
    • Q504V4
    • Q8WUE7
    • Q96T15
    • Q9NZE4

    Protein attributes for EXOC1 Gene

    Size:
    894 amino acids
    Molecular mass:
    101982 Da
    Quaternary structure:
    • The exocyst complex is composed of EXOC1, EXOC2, EXOC3, EXOC4, EXOC5, EXOC6, EXOC7 and EXOC8.
    SequenceCaution:
    • Sequence=AAF64268.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for EXOC1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for EXOC1 Gene

Post-translational modifications for EXOC1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for EXOC1 Gene

Domains & Families for EXOC1 Gene

Gene Families for EXOC1 Gene

Protein Domains for EXOC1 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for EXOC1 Gene

Graphical View of Domain Structure for InterPro Entry

Q9NV70

UniProtKB/Swiss-Prot:

EXOC1_HUMAN :
  • Belongs to the SEC3 family.
Family:
  • Belongs to the SEC3 family.
genes like me logo Genes that share domains with EXOC1: view

Function for EXOC1 Gene

Molecular function for EXOC1 Gene

UniProtKB/Swiss-Prot Function:
Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane.

Gene Ontology (GO) - Molecular Function for EXOC1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 17043677
GO:0005546 phosphatidylinositol-4,5-bisphosphate binding IBA --
GO:0017049 GTP-Rho binding IBA --
genes like me logo Genes that share ontologies with EXOC1: view
genes like me logo Genes that share phenotypes with EXOC1: view

Animal Models for EXOC1 Gene

MGI Knock Outs for EXOC1:

Animal Model Products

CRISPR Products

miRNA for EXOC1 Gene

miRTarBase miRNAs that target EXOC1

Inhibitory RNA Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for EXOC1 Gene

Localization for EXOC1 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for EXOC1 gene
Compartment Confidence
plasma membrane 5
cytosol 5
cytoskeleton 3
nucleus 2
endoplasmic reticulum 1
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for EXOC1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000145 exocyst NAS 11406615
GO:0005737 cytoplasm IDA 25591774
GO:0005829 cytosol TAS --
GO:0005886 plasma membrane TAS --
GO:0016020 membrane IDA 19946888
genes like me logo Genes that share ontologies with EXOC1: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for EXOC1 Gene

Pathways & Interactions for EXOC1 Gene

genes like me logo Genes that share pathways with EXOC1: view

Pathways by source for EXOC1 Gene

Gene Ontology (GO) - Biological Process for EXOC1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006810 transport IEA --
GO:0006887 exocytosis NAS 11406615
GO:0006893 Golgi to plasma membrane transport IBA --
GO:0015031 protein transport IEA --
GO:0016241 regulation of macroautophagy TAS 21241894
genes like me logo Genes that share ontologies with EXOC1: view

No data available for SIGNOR curated interactions for EXOC1 Gene

Transcripts for EXOC1 Gene

Unigene Clusters for EXOC1 Gene

Exocyst complex component 1:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for EXOC1 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b · 2c · 2d ^ 3 ^ 4 ^ 5a · 5b ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10a · 10b · 10c ^ 11a · 11b ^ 12 ^ 13 ^ 14a · 14b ^ 15a ·
SP1: - - - - - -
SP2: - - - -
SP3: - -
SP4: - - -
SP5:
SP6:
SP7:
SP8: -
SP9:

ExUns: 15b · 15c ^ 16 ^ 17 ^ 18 ^ 19
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:

Relevant External Links for EXOC1 Gene

GeneLoc Exon Structure for
EXOC1
ECgene alternative splicing isoforms for
EXOC1

Expression for EXOC1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for EXOC1 Gene

Protein differential expression in normal tissues from HIPED for EXOC1 Gene

This gene is overexpressed in Bone (21.3) and Peripheral blood mononuclear cells (9.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for EXOC1 Gene



Protein tissue co-expression partners for EXOC1 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of EXOC1 Gene:

EXOC1

SOURCE GeneReport for Unigene cluster for EXOC1 Gene:

Hs.269665

Evidence on tissue expression from TISSUES for EXOC1 Gene

  • Blood(4.3)
  • Skin(4.3)
  • Nervous system(4.3)
  • Bone marrow(4.2)
  • Liver(4.2)
genes like me logo Genes that share expression patterns with EXOC1: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for EXOC1 Gene

Orthologs for EXOC1 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for EXOC1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia EXOC1 34 35
  • 99.81 (n)
oppossum
(Monodelphis domestica)
Mammalia EXOC1 35
  • 95 (a)
OneToOne
dog
(Canis familiaris)
Mammalia EXOC1 34 35
  • 94.52 (n)
cow
(Bos Taurus)
Mammalia EXOC1 34 35
  • 94.22 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia EXOC1 35
  • 92 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Exoc1 34 16 35
  • 88.52 (n)
chicken
(Gallus gallus)
Aves EXOC1 34 35
  • 84.6 (n)
lizard
(Anolis carolinensis)
Reptilia EXOC1 35
  • 89 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia exoc1 34
  • 79.14 (n)
African clawed frog
(Xenopus laevis)
Amphibia Xl.15011 34
zebrafish
(Danio rerio)
Actinopterygii exoc1 34 35
  • 74.34 (n)
wufb58e03 34
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP012417 34
  • 50.96 (n)
fruit fly
(Drosophila melanogaster)
Insecta sec3 35 34
  • 49.55 (n)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea sec-3 34 35
  • 46.34 (n)
thale cress
(Arabidopsis thaliana)
eudicotyledons SEC3A 34
  • 42.48 (n)
rice
(Oryza sativa)
Liliopsida Os11g0276000 34
  • 40.33 (n)
Species where no ortholog for EXOC1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for EXOC1 Gene

ENSEMBL:
Gene Tree for EXOC1 (if available)
TreeFam:
Gene Tree for EXOC1 (if available)

Paralogs for EXOC1 Gene

Paralogs for EXOC1 Gene

(1) SIMAP similar genes for EXOC1 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with EXOC1: view

Variants for EXOC1 Gene

Sequence variations from dbSNP and Humsavar for EXOC1 Gene

SNP ID Clin Chr 04 pos Sequence Context AA Info Type
rs1000012643 -- 55,894,223(+) GGGAG(A/G)CTGAG intron-variant
rs1000107285 -- 55,873,900(+) ATTAT(A/G)TACTC intron-variant
rs1000138796 -- 55,901,739(+) GAAGT(A/C)GCAAC intron-variant
rs1000237520 -- 55,905,555(+) TGGCT(A/G)TATTG intron-variant, downstream-variant-500B
rs1000294258 -- 55,895,801(+) GTGGA(A/G)CTAAG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for EXOC1 Gene

Variant ID Type Subtype PubMed ID
esv3600566 CNV loss 21293372
nsv1005845 CNV gain 25217958
nsv10496 CNV loss 18304495

Variation tolerance for EXOC1 Gene

Residual Variation Intolerance Score: 4.73% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.88; 35.18% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for EXOC1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
EXOC1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for EXOC1 Gene

Disorders for EXOC1 Gene

MalaCards: The human disease database

(1) MalaCards diseases for EXOC1 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
commensal bacterial infectious disease
- elite association - COSMIC cancer census association via MalaCards
Search EXOC1 in MalaCards View complete list of genes associated with diseases

Relevant External Links for EXOC1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
EXOC1
genes like me logo Genes that share disorders with EXOC1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for EXOC1 Gene

Publications for EXOC1 Gene

  1. The brain exocyst complex interacts with RalA in a GTP-dependent manner: identification of a novel mammalian Sec3 gene and a second Sec15 gene. (PMID: 11406615) Brymora A. … Robinson P.J. (J. Biol. Chem. 2001) 2 3 4 64
  2. Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells. (PMID: 11042152) Zhang Q.-H. … Chen Z. (Genome Res. 2000) 2 3 4 64
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  5. Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides. (PMID: 12665801) Gevaert K. … Vandekerckhove J. (Nat. Biotechnol. 2003) 3 4 64

Products for EXOC1 Gene

Sources for EXOC1 Gene

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