Free for academic non-profit institutions. Other users need a Commercial license

Aliases for EXOC1 Gene

Aliases for EXOC1 Gene

  • Exocyst Complex Component 1 2 3 5
  • Exocyst Complex Component Sec3 3 4
  • SEC3L1 3 4
  • SEC3 3 4
  • SEC3-Like 1 (S. Cerevisiae) 2
  • SEC3-Like 1 3
  • BM-102 3
  • SEC3P 3

External Ids for EXOC1 Gene

Previous HGNC Symbols for EXOC1 Gene

  • SEC3L1

Previous GeneCards Identifiers for EXOC1 Gene

  • GC04P056561
  • GC04P056414
  • GC04P056719
  • GC04P052673

Summaries for EXOC1 Gene

Entrez Gene Summary for EXOC1 Gene

  • The protein encoded by this gene is a component of the exocyst complex, a multiple protein complex essential for targeting exocytic vesicles to specific docking sites on the plasma membrane. Though best characterized in yeast, the component proteins and functions of the exocyst complex have been demonstrated to be highly conserved in higher eukaryotes. At least eight components of the exocyst complex, including this protein, are found to interact with the actin cytoskeletal remodeling and vesicle transport machinery. Alternatively spliced transcript variants encoding distinct isoforms have been described. [provided by RefSeq, Jul 2008]

GeneCards Summary for EXOC1 Gene

EXOC1 (Exocyst Complex Component 1) is a Protein Coding gene. Diseases associated with EXOC1 include commensal bacterial infectious disease. Among its related pathways are Transport to the Golgi and subsequent modification and Arf6 trafficking events. GO annotations related to this gene include phosphatidylinositol-4,5-bisphosphate binding and GTP-Rho binding. An important paralog of this gene is STXBP6.

UniProtKB/Swiss-Prot for EXOC1 Gene

  • Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane.

Gene Wiki entry for EXOC1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for EXOC1 Gene

Genomics for EXOC1 Gene

Regulatory Elements for EXOC1 Gene

Promoters for EXOC1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around EXOC1 on UCSC Golden Path with GeneCards custom track

Genomic Location for EXOC1 Gene

Chromosome:
4
Start:
55,853,616 bp from pter
End:
55,905,078 bp from pter
Size:
51,463 bases
Orientation:
Plus strand

Genomic View for EXOC1 Gene

Genes around EXOC1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
EXOC1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for EXOC1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for EXOC1 Gene

Proteins for EXOC1 Gene

  • Protein details for EXOC1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NV70-EXOC1_HUMAN
    Recommended name:
    Exocyst complex component 1
    Protein Accession:
    Q9NV70
    Secondary Accessions:
    • Q504V4
    • Q8WUE7
    • Q96T15
    • Q9NZE4

    Protein attributes for EXOC1 Gene

    Size:
    894 amino acids
    Molecular mass:
    101982 Da
    Quaternary structure:
    • The exocyst complex is composed of EXOC1, EXOC2, EXOC3, EXOC4, EXOC5, EXOC6, EXOC7 and EXOC8.
    SequenceCaution:
    • Sequence=AAF64268.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for EXOC1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for EXOC1 Gene

Proteomics data for EXOC1 Gene at MOPED

Post-translational modifications for EXOC1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for EXOC1 Gene

No data available for DME Specific Peptides for EXOC1 Gene

Domains & Families for EXOC1 Gene

Gene Families for EXOC1 Gene

Protein Domains for EXOC1 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for EXOC1 Gene

Graphical View of Domain Structure for InterPro Entry

Q9NV70

UniProtKB/Swiss-Prot:

EXOC1_HUMAN :
  • Belongs to the SEC3 family.
Family:
  • Belongs to the SEC3 family.
genes like me logo Genes that share domains with EXOC1: view

Function for EXOC1 Gene

Molecular function for EXOC1 Gene

UniProtKB/Swiss-Prot Function:
Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane.

Gene Ontology (GO) - Molecular Function for EXOC1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 24344185
GO:0005546 phosphatidylinositol-4,5-bisphosphate binding IBA --
genes like me logo Genes that share ontologies with EXOC1: view
genes like me logo Genes that share phenotypes with EXOC1: view

Animal Model Products

CRISPR Products

miRNA for EXOC1 Gene

miRTarBase miRNAs that target EXOC1

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for EXOC1 Gene

Localization for EXOC1 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for EXOC1 Gene COMPARTMENTS Subcellular localization image for EXOC1 gene
Compartment Confidence
cytosol 5
plasma membrane 5
cytoskeleton 2
nucleus 2

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for EXOC1 Gene

Pathways & Interactions for EXOC1 Gene

genes like me logo Genes that share pathways with EXOC1: view

Pathways by source for EXOC1 Gene

Gene Ontology (GO) - Biological Process for EXOC1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006996 organelle organization TAS --
GO:0016241 regulation of macroautophagy TAS 21241894
GO:0050714 positive regulation of protein secretion IMP 25591774
GO:0061024 membrane organization TAS --
genes like me logo Genes that share ontologies with EXOC1: view

No data available for SIGNOR curated interactions for EXOC1 Gene

Drugs & Compounds for EXOC1 Gene

No Compound Related Data Available

Transcripts for EXOC1 Gene

Unigene Clusters for EXOC1 Gene

Exocyst complex component 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for EXOC1 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b · 2c · 2d ^ 3 ^ 4 ^ 5a · 5b ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10a · 10b · 10c ^ 11a · 11b ^ 12 ^ 13 ^ 14a · 14b ^ 15a ·
SP1: - - - - - -
SP2: - - - -
SP3: - -
SP4: - - -
SP5:
SP6:
SP7:
SP8: -
SP9:

ExUns: 15b · 15c ^ 16 ^ 17 ^ 18 ^ 19
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:

Relevant External Links for EXOC1 Gene

GeneLoc Exon Structure for
EXOC1
ECgene alternative splicing isoforms for
EXOC1

Expression for EXOC1 Gene

mRNA expression in normal human tissues for EXOC1 Gene

Protein differential expression in normal tissues from HIPED for EXOC1 Gene

This gene is overexpressed in Bone (21.3) and Peripheral blood mononuclear cells (9.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for EXOC1 Gene



SOURCE GeneReport for Unigene cluster for EXOC1 Gene Hs.269665

genes like me logo Genes that share expression patterns with EXOC1: view

Protein tissue co-expression partners for EXOC1 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for EXOC1 Gene

Orthologs for EXOC1 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for EXOC1 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia EXOC1 35
  • 94.22 (n)
  • 98.66 (a)
EXOC1 36
  • 98 (a)
OneToOne
dog
(Canis familiaris)
Mammalia EXOC1 35
  • 94.52 (n)
  • 98.55 (a)
EXOC1 36
  • 99 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Exoc1 35
  • 88.52 (n)
  • 97.2 (a)
Exoc1 16
Exoc1 36
  • 96 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia EXOC1 35
  • 99.81 (n)
  • 100 (a)
EXOC1 36
  • 100 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia EXOC1 36
  • 95 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia EXOC1 36
  • 92 (a)
OneToOne
chicken
(Gallus gallus)
Aves EXOC1 35
  • 84.6 (n)
  • 94.18 (a)
EXOC1 36
  • 94 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia EXOC1 36
  • 89 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia exoc1 35
  • 79.14 (n)
  • 88.16 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.15011 35
zebrafish
(Danio rerio)
Actinopterygii exoc1 35
  • 74.34 (n)
  • 86.39 (a)
wufb58e03 35
exoc1 36
  • 85 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP012417 35
  • 50.96 (n)
  • 42.48 (a)
fruit fly
(Drosophila melanogaster)
Insecta sec3 35
  • 49.55 (n)
  • 43.02 (a)
sec3 36
  • 41 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea sec-3 35
  • 46.34 (n)
  • 36.25 (a)
sec-3 36
  • 34 (a)
OneToMany
thale cress
(Arabidopsis thaliana)
eudicotyledons SEC3A 35
  • 42.48 (n)
  • 28.01 (a)
rice
(Oryza sativa)
Liliopsida Os11g0276000 35
  • 40.33 (n)
  • 24.48 (a)
Species with no ortholog for EXOC1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for EXOC1 Gene

ENSEMBL:
Gene Tree for EXOC1 (if available)
TreeFam:
Gene Tree for EXOC1 (if available)

Paralogs for EXOC1 Gene

Paralogs for EXOC1 Gene

(1) SIMAP similar genes for EXOC1 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with EXOC1: view

Variants for EXOC1 Gene

Sequence variations from dbSNP and Humsavar for EXOC1 Gene

SNP ID Clin Chr 04 pos Sequence Context AA Info Type
rs769013 -- 55,868,679(+) TTACT(C/G)TTCTT intron-variant
rs1072799 -- 55,871,514(-) gCTCT(C/G)GTCTA intron-variant
rs719007 -- 55,875,195(-) TTATT(A/G)TAGCT intron-variant
rs719397 -- 55,852,952(-) ATTCA(A/G)GCATG upstream-variant-2KB
rs895611 -- 55,851,985(-) ATGGC(C/T)TAAGT upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for EXOC1 Gene

Variant ID Type Subtype PubMed ID
nsv10496 CNV Loss 18304495
nsv879024 CNV Gain 21882294
nsv879025 CNV Gain 21882294

Variation tolerance for EXOC1 Gene

Residual Variation Intolerance Score: 4.73% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.88; 35.18% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for EXOC1 Gene

HapMap Linkage Disequilibrium report
EXOC1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for EXOC1 Gene

Disorders for EXOC1 Gene

MalaCards: The human disease database

(1) MalaCards diseases for EXOC1 Gene - From: DISEASES

Disorder Aliases PubMed IDs
commensal bacterial infectious disease
- elite association - COSMIC cancer census association via MalaCards
Search EXOC1 in MalaCards View complete list of genes associated with diseases

Relevant External Links for EXOC1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
EXOC1
genes like me logo Genes that share disorders with EXOC1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for EXOC1 Gene

Publications for EXOC1 Gene

  1. The brain exocyst complex interacts with RalA in a GTP-dependent manner: identification of a novel mammalian Sec3 gene and a second Sec15 gene. (PMID: 11406615) Brymora A. … Robinson P.J. (J. Biol. Chem. 2001) 2 3 4 67
  2. The Sec6/8 complex in mammalian cells: characterization of mammalian Sec3, subunit interactions, and expression of subunits in polarized cells. (PMID: 11493706) Matern H.T. … Scheller R.H. (Proc. Natl. Acad. Sci. U.S.A. 2001) 3 23
  3. Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells. (PMID: 11042152) Zhang Q.-H. … Chen Z. (Genome Res. 2000) 2 3
  4. Ezrin/Exocyst complex regulates mucin 5AC secretion induced by neutrophil elastase in human airway epithelial cells. (PMID: 25591774) Li Q. … Zhou X.D. (Cell. Physiol. Biochem. 2015) 3
  5. Temporal proteomics of NGF-TrkA signaling identifies an inhibitory role for the E3 ligase Cbl-b in neuroblastoma cell differentiation. (PMID: 25921289) Emdal K.B. … Olsen J.V. (Sci Signal 2015) 3

Products for EXOC1 Gene

Sources for EXOC1 Gene

Back to Top

Content