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Aliases for EXO5 Gene

Aliases for EXO5 Gene

  • Exonuclease 5 2 3 5
  • Defects In Morphology Protein 1 Homolog 3 4
  • C1orf176 3 4
  • Exo V 3 4
  • HExo5 3 4
  • DEM1 3 4
  • Defects In Morphology 1 Homolog (S. Cerevisiae) 2
  • Chromosome 1 Open Reading Frame 176 2
  • Defects In Morphology 1 Homolog 3
  • Probable Exonuclease V 3
  • EC 3.1.-.- 4

External Ids for EXO5 Gene

Previous HGNC Symbols for EXO5 Gene

  • C1orf176
  • DEM1

Previous GeneCards Identifiers for EXO5 Gene

  • GC01P040975

Summaries for EXO5 Gene

GeneCards Summary for EXO5 Gene

EXO5 (Exonuclease 5) is a Protein Coding gene. GO annotations related to this gene include protein homodimerization activity and single-stranded DNA 3-5 exodeoxyribonuclease activity.

UniProtKB/Swiss-Prot for EXO5 Gene

  • Single-stranded DNA (ssDNA) bidirectional exonuclease involved in DNA repair. Probably involved in DNA repair following ultraviolet (UV) irradiation and interstrand cross-links (ICLs) damage. Has both 5-3 and 3-5 exonuclease activities with a strong preference for 5-ends. Acts as a sliding exonuclease that loads at ssDNA ends and then slides along the ssDNA prior to cutting; however the sliding and the 3-5 exonuclease activities are abolished upon binding to the replication protein A (RPA) complex that enforces 5-directionality activity.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for EXO5 Gene

Genomics for EXO5 Gene

Regulatory Elements for EXO5 Gene

Enhancers for EXO5 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around EXO5 on UCSC Golden Path with GeneCards custom track

Promoters for EXO5 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around EXO5 on UCSC Golden Path with GeneCards custom track

Genomic Location for EXO5 Gene

Chromosome:
1
Start:
40,508,719 bp from pter
End:
40,517,725 bp from pter
Size:
9,007 bases
Orientation:
Plus strand

Genomic View for EXO5 Gene

Genes around EXO5 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
EXO5 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for EXO5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for EXO5 Gene

Proteins for EXO5 Gene

  • Protein details for EXO5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9H790-EXO5_HUMAN
    Recommended name:
    Exonuclease V
    Protein Accession:
    Q9H790
    Secondary Accessions:
    • D3DPV4
    • Q5SWM7
    • Q5SWM8
    • Q5SWM9
    • Q5SWN0
    • Q5SWN1
    • Q8WTW9

    Protein attributes for EXO5 Gene

    Size:
    373 amino acids
    Molecular mass:
    41816 Da
    Cofactor:
    Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
    Cofactor:
    Name=[4Fe-4S] cluster; Xref=ChEBI:CHEBI:49883;
    Quaternary structure:
    • Monomer; monomeric form has weak exonuclease activity. Homodimer; homodimeric form is unsure but has much higher exonuclease activity, suggesting that it could homodimerize upon DNA-binding. Interacts with the replication protein A (RPA) complex.
    SequenceCaution:
    • Sequence=CAI16298.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=CAI16299.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=CAI16300.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=CAI16301.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=CAI16302.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

neXtProt entry for EXO5 Gene

Proteomics data for EXO5 Gene at MOPED

Post-translational modifications for EXO5 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for EXO5 Gene

Domains & Families for EXO5 Gene

Gene Families for EXO5 Gene

Protein Domains for EXO5 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for EXO5 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9H790

UniProtKB/Swiss-Prot:

EXO5_HUMAN :
  • Belongs to the EXO5 family.
Family:
  • Belongs to the EXO5 family.
genes like me logo Genes that share domains with EXO5: view

Function for EXO5 Gene

Molecular function for EXO5 Gene

UniProtKB/Swiss-Prot Function:
Single-stranded DNA (ssDNA) bidirectional exonuclease involved in DNA repair. Probably involved in DNA repair following ultraviolet (UV) irradiation and interstrand cross-links (ICLs) damage. Has both 5-3 and 3-5 exonuclease activities with a strong preference for 5-ends. Acts as a sliding exonuclease that loads at ssDNA ends and then slides along the ssDNA prior to cutting; however the sliding and the 3-5 exonuclease activities are abolished upon binding to the replication protein A (RPA) complex that enforces 5-directionality activity.

Enzyme Numbers (IUBMB) for EXO5 Gene

Gene Ontology (GO) - Molecular Function for EXO5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008310 single-stranded DNA 3-5 exodeoxyribonuclease activity TAS 23095756
GO:0042803 protein homodimerization activity TAS 23095756
genes like me logo Genes that share ontologies with EXO5: view
genes like me logo Genes that share phenotypes with EXO5: view

Animal Model Products

CRISPR Products

miRNA for EXO5 Gene

miRTarBase miRNAs that target EXO5

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for EXO5 Gene

Localization for EXO5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for EXO5 Gene

Nucleus. Cytoplasm, cytosol. Note=Localizes to repair foci in response to DNA damage.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for EXO5 Gene COMPARTMENTS Subcellular localization image for EXO5 gene
Compartment Confidence
cytosol 5
nucleus 5
endoplasmic reticulum 1
mitochondrion 1
peroxisome 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for EXO5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IDA --
genes like me logo Genes that share ontologies with EXO5: view

Pathways & Interactions for EXO5 Gene

SuperPathways for EXO5 Gene

No Data Available

Interacting Proteins for EXO5 Gene

STRING Interaction Network Preview (showing 2 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000296380%0d%0a9606.ENSP00000254719%0d%0a9606.ENSP00000344818%0d%0a
Selected Interacting proteins: ENSP00000296380 for EXO5 Gene via STRING

Gene Ontology (GO) - Biological Process for EXO5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0090305 nucleic acid phosphodiester bond hydrolysis IEA --
genes like me logo Genes that share ontologies with EXO5: view

No data available for Pathways by source and SIGNOR curated interactions for EXO5 Gene

Drugs & Compounds for EXO5 Gene

No Compound Related Data Available

Transcripts for EXO5 Gene

Unigene Clusters for EXO5 Gene

Exonuclease 5:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for EXO5 Gene

ExUns: 1a · 1b · 1c · 1d · 1e · 1f · 1g · 1h · 1i · 1j · 1k ^ 2a · 2b ^ 3 ^ 4a · 4b · 4c · 4d · 4e · 4f · 4g · 4h · 4i
SP1: -
SP2: - -
SP3: - -
SP4: - - -
SP5: - - -
SP6: - - - - -
SP7: - -
SP8: - - - -
SP9: - - - - - -
SP10:
SP11: - - - - -

Relevant External Links for EXO5 Gene

GeneLoc Exon Structure for
EXO5
ECgene alternative splicing isoforms for
EXO5

Expression for EXO5 Gene

mRNA expression in normal human tissues for EXO5 Gene

Protein differential expression in normal tissues from HIPED for EXO5 Gene

This gene is overexpressed in CD4 Tcells (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MOPED, and MaxQB for EXO5 Gene



SOURCE GeneReport for Unigene cluster for EXO5 Gene Hs.59584

genes like me logo Genes that share expression patterns with EXO5: view

Protein tissue co-expression partners for EXO5 Gene

- Elite partner

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for EXO5 Gene

Orthologs for EXO5 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for EXO5 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia EXO5 35
  • 85.63 (n)
  • 80.85 (a)
EXO5 36
  • 81 (a)
OneToOne
dog
(Canis familiaris)
Mammalia EXO5 35
  • 87.24 (n)
  • 84.64 (a)
EXO5 36
  • 81 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Exo5 35
  • 85.17 (n)
  • 83.91 (a)
Exo5 16
Exo5 36
  • 84 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia DEM1 35
  • 99.11 (n)
  • 98.39 (a)
DEM1 36
  • 98 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Exo5 35
  • 84.36 (n)
  • 82.04 (a)
oppossum
(Monodelphis domestica)
Mammalia EXO5 36
  • 68 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia EXO5 36
  • 33 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii zgc:123272 35
  • 51.87 (n)
  • 47.34 (a)
EXO5 36
  • 39 (a)
OneToOne
bread mold
(Neurospora crassa)
Ascomycetes NCU04450 35
  • 45.5 (n)
  • 31.29 (a)
Species with no ortholog for EXO5:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for EXO5 Gene

ENSEMBL:
Gene Tree for EXO5 (if available)
TreeFam:
Gene Tree for EXO5 (if available)

Paralogs for EXO5 Gene

No data available for Paralogs for EXO5 Gene

Variants for EXO5 Gene

Sequence variations from dbSNP and Humsavar for EXO5 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs1134586 - 40,514,887(-) AGTGT(C/T)CAACA reference, missense
rs11208299 - 40,515,059(+) GGAAG(G/T)GGAGG reference, missense
rs3795343 -- 40,515,579(-) GTACA(C/T)GTCCG reference, synonymous-codon
rs3795344 -- 40,515,558(-) GCCTC(C/T)TCCAC reference, synonymous-codon
rs4660413 -- 40,511,941(+) TGGTG(C/G)GATCT intron-variant

Variation tolerance for EXO5 Gene

Residual Variation Intolerance Score: 59.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.37; 76.91% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for EXO5 Gene

Human Gene Mutation Database (HGMD)
EXO5

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for EXO5 Gene

Disorders for EXO5 Gene

Relevant External Links for EXO5

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
EXO5

No disorders were found for EXO5 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for EXO5 Gene

Publications for EXO5 Gene

  1. Human exonuclease 5 is a novel sliding exonuclease required for genome stability. (PMID: 23095756) Sparks J.L. … Burgers P.M. (J. Biol. Chem. 2012) 2 3 4 67
  2. hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PMID: 17207965) Lamesch P. … Vidal M. (Genomics 2007) 3
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3
  4. Large-scale characterization of HeLa cell nuclear phosphoproteins. (PMID: 15302935) Beausoleil S.A. … Gygi S.P. (Proc. Natl. Acad. Sci. U.S.A. 2004) 3
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3

Products for EXO5 Gene

Sources for EXO5 Gene

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