Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 
or upload a file of gene symbols


Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

EWSR1 Gene

protein-coding   GIFtS: 61
GCID: GC22P029663

EWS RNA-Binding Protein 1

(Previous name: Ewing sarcoma breakpoint region 1)
Microbiology & Infectious Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
EWS RNA-Binding Protein 11 2     Ewings Sarcoma EWS-Fli1 (Type 1) Oncogene2
EWS2 3 5     RNA-Binding Protein EWS2
Ewing Sarcoma Breakpoint Region 11 2     Ewing Sarcoma Breakpoint Region 1 Protein3
bK984G1.42     EWS Oncogene3

External Ids:    HGNC: 35081   Entrez Gene: 21302   Ensembl: ENSG000001829447   OMIM: 1334505   UniProtKB: Q018443   

Export aliases for EWSR1 gene to outside databases

Previous GC identifers: GC22P026360 GC22P027988 GC22P012628


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for EWSR1 Gene:
This gene encodes a multifunctional protein that is involved in various cellular processes, including gene
expression, cell signaling, and RNA processing and transport. The protein includes an N-terminal transcriptional
activation domain and a C-terminal RNA-binding domain. Chromosomal translocations between this gene and various
genes encoding transcription factors result in the production of chimeric proteins that are involved in
tumorigenesis. These chimeric proteins usually consist of the N-terminal transcriptional activation domain of
this protein fused to the C-terminal DNA-binding domain of the transcription factor protein. Mutations in this
gene, specifically a t(11;22)(q24;q12) translocation, are known to cause Ewing sarcoma as well as neuroectodermal
and various other tumors. Alternative splicing of this gene results in multiple transcript variants. Related
pseudogenes have been identified on chromosomes 1 and 14. (provided by RefSeq, Jul 2009)

GeneCards Summary for EWSR1 Gene: 
EWSR1 (EWS RNA-binding protein 1) is a protein-coding gene. Diseases associated with EWSR1 include ewing's family of tumors, and melanoma of soft part, and among its related super-pathways are Fanconi's Anaemia Pathway. GO annotations related to this gene include RNA binding and calmodulin binding. An important paralog of this gene is TAF15.

UniProtKB/Swiss-Prot: EWS_HUMAN, Q01844
Function: Might normally function as a transcriptionnal repressor. EWS-fusion-proteins (EFPS) may play a role in
the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function
of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of
the fusion protein target genes

Gene Wiki entry for EWSR1 (Ewing sarcoma breakpoint region 1) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000022.10  NT_011520.12  NC_018933.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the EWSR1 gene promoter:
         AML1a   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidEWSR1 promoter sequence
   Search SABiosciences Chromatin IP Primers for EWSR1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat EWSR1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 22q12.2   Ensembl cytogenetic band:  22q12.2   HGNC cytogenetic band: 22q12.2

EWSR1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
EWSR1 gene location

GeneLoc information about chromosome 22         GeneLoc Exon Structure

GeneLoc location for GC22P029663:  view genomic region     (about GC identifiers)

Start:
29,663,998 bp from pter      End:
29,696,515 bp from pter
Size:
32,518 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: EWS_HUMAN, Q01844 (See protein sequence)
Recommended Name: RNA-binding protein EWS  
Size: 656 amino acids; 68478 Da
Subunit: Binds POLR2C, SF1, calmodulin and RNA. Interacts with PTK2B/FAK2 and TDRD3. Binds calmodulin in the
presence, but not in the absence, of calcium ion
Subcellular location: Nucleus. Cytoplasm. Cell membrane. Note=Relocates from cytoplasm to ribosomes upon
PTK2B/FAK2 activation
Sequence caution: Sequence=CAA70044.1; Type=Erroneous initiation;
1 PDB 3D structure from and Proteopedia for EWSR1:
2CPE (3D)    
Secondary accessions: B0QYK1 Q5THL0 Q92635 Q96FE8 Q96MN4 Q96MX4 Q9BWA2
Alternative splicing: 6 isoforms:  Q01844-1   Q01844-2   Q01844-3   Q01844-4   Q01844-5   Q01844-6   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for EWSR1: NX_Q01844

Explore proteomics data for EWSR1 at MOPED 

Post-translational modifications:

  • UniProtKB: Phosphorylated; calmodulin-binding inhibits phosphorylation of Ser-266
  • UniProtKB: Highly methylated on arginine residues. Methylation is mediated by PRMT1 and, at lower level by PRMT8
  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q01844

  • EWSR1 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    EWSR1 Protein Expression
    REFSEQ proteins (5 alternative transcripts): 
    NP_001156757.1  NP_001156758.1  NP_001156759.1  NP_005234.1  NP_053733.2  

    ENSEMBL proteins: 
     ENSP00000416171   ENSP00000381031   ENSP00000406824   ENSP00000405947   ENSP00000385726  
     ENSP00000412670   ENSP00000395200   ENSP00000330516   ENSP00000400142   ENSP00000327456  
     ENSP00000393637   ENSP00000331699   ENSP00000353204   ENSP00000330896  

    Human Recombinant Protein Products for EWSR1: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein for EWSR1
    OriGene Protein Over-expression Lysate for EWSR1
    OriGene MassSpec for EWSR1 
    OriGene Custom Protein Services for EWSR1
    GenScript Custom Purified and Recombinant Proteins Services for EWSR1
    Novus Biologicals EWSR1 Protein
    Novus Biologicals EWSR1 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for EWSR1 

    Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005622intracellular ----
    GO:0005634nucleus IEA--
    GO:0005737cytoplasm IEA--
    GO:0005886plasma membrane IEA--

    EWSR1 for ontologies           About GeneDecksing



    EWSR1 Antibody Products: 
    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    Cell Signaling Technology (CST) Antibodies for EWSR1  (EWS)
    OriGene Antibodies for EWSR1
    OriGene Custom Antibody Services for EWSR1
    GenScript Custom Superior Antibodies Services for EWSR1
    Novus Biologicals EWSR1 Antibodies
    Abcam antibodies for EWSR1
    Cloud-Clone Corp. Antibodies for EWSR1 
    ThermoFisher Antibody for EWSR1
    LSBio Antibodies in human, mouse, rat for EWSR1 

    Assay Products for EWSR1: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for EWSR1
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for EWSR1
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for EWSR1 
    Cloud-Clone Corp. CLIAs for EWSR1


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    RBM: RNA binding motif (RRM) containing

    3 InterPro protein domains:
     IPR012677 Nucleotide-bd_a/b_plait
     IPR001876 Znf_RanBP2
     IPR000504 RRM_dom

    Graphical View of Domain Structure for InterPro Entry Q01844

    ProtoNet protein and cluster: Q01844

    2 Blocks protein domains:
    IPB000504 RNA-binding region RNP-1 (RNA recognition motif)
    IPB001876 Zn-finger


    UniProtKB/Swiss-Prot: EWS_HUMAN, Q01844
    Domain: EWS activation domain (EAD) functions as a potent activation domain in EFPS. EWSR1 binds POLR2C but not
    POLR2E or POLR2G, whereas the isolated EAD binds POLR2E and POLR2G but not POLR2C. Cis-linked RNA-binding domain
    (RBD) can strongly and specifically repress trans-activation by the EAD
    Similarity: Belongs to the RRM TET family
    Similarity: Contains 1 IQ domain
    Similarity: Contains 1 RanBP2-type zinc finger
    Similarity: Contains 1 RRM (RNA recognition motif) domain


    EWSR1 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: EWS_HUMAN, Q01844
    Function: Might normally function as a transcriptionnal repressor. EWS-fusion-proteins (EFPS) may play a role in
    the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function
    of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of
    the fusion protein target genes

         Gene Ontology (GO): 5/7 molecular function terms (GO ID links to tree view) (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000166nucleotide binding IEA--
    GO:0003676nucleic acid binding ----
    GO:0003723RNA binding IEA--
    GO:0005515protein binding IPI16189514
    GO:0005516calmodulin binding IEA--
         
    EWSR1 for ontologies           About GeneDecksing


    Phenotypes:
         3 GenomeRNAi human phenotypes for EWSR1:
     Decreased nuclei size in G2M  Increased cell death HMECs cel  Increased gamma-H2AX phosphory 

         14 MGI mutant phenotypes (inferred from 3 alleles(MGI details for Ewsr1):
     adipose tissue  cellular  endocrine/exocrine gland  growth/size  hematopoietic system 
     immune system  integument  mortality/aging  muscle  normal 
     renal/urinary system  reproductive system  skeleton  tumorigenesis 

    EWSR1 for phenotypes           About GeneDecksing

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for EWSR1 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for EWSR1

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for EWSR1 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for EWSR1 

    miRNA
    Products:
        
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat EWSR1
    8/17 QIAGEN miScript miRNA Assays for microRNAs that regulate EWSR1 (see all 17):
    hsa-miR-1178 hsa-miR-136 hsa-miR-875-5p hsa-miR-548k hsa-miR-340 hsa-miR-29b-1* hsa-miR-299-5p hsa-miR-3688-3p
    SwitchGear 3'UTR luciferase reporter plasmidEWSR1 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for EWSR1
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat EWSR1

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for EWSR1
    Sirion Biotech Customized adenovirus for overexpression of EWSR1

    Clone
    Products:
         
    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene clones in human, mouse for EWSR1 (see all 32)
    OriGene ORF clones in mouse, rat for EWSR1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 5): EWSR1 (NM_005243)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for EWSR1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat EWSR1
    Sirion Biotech Customized lentivirus for stable overexpression of EWSR1 
                         Customized lentivirus expression plasmids for stable overexpression of EWSR1 

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for EWSR1
    Search LifeMap BioReagents cell lines for EWSR1
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for EWSR1


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for EWSR1 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Fanconi Anemia pathway
    BARD1 signaling events0.41
    2Transcriptional misregulation in cancer
    Transcriptional misregulation in cancer
    3Chromatin Regulation / Acetylation
    Chromatin Regulation / Acetylation
    4Translational Control
    Translational Control

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    2 Cell Signaling Technology (CST) Pathways for EWSR1
        Chromatin Regulation / Acetylation
    Translational Control

    1 BioSystems Pathway for EWSR1
        BARD1 signaling events


    1         Kegg Pathway  (Kegg details for EWSR1):
        Transcriptional misregulation in cancer


    EWSR1 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for EWSR1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/865 Interacting proteins for EWSR1 (Q018441, 2, 3 ENSP000003810314) via UniProtKB, MINT, STRING, and/or I2D (see all 865)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    PCBP1Q153652, 3, ENSP000003055564MINT-2858723 MINT-7947479 I2D: score=2 STRING: ENSP00000305556
    SMN1Q166372, 3, ENSP000003700834MINT-7947479 I2D: score=1 STRING: ENSP00000370083
    FASNP493272, 3, ENSP000003045924MINT-7947479 I2D: score=3 STRING: ENSP00000304592
    RPL31P628992, 3, ENSP000003867174MINT-7947479 I2D: score=3 STRING: ENSP00000386717
    ATXN3P542522, 3, ENSP000003523244MINT-2858647 I2D: score=2 STRING: ENSP00000352324
    About this table

    Gene Ontology (GO): 2 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006351transcription, DNA-dependent IEA--
    GO:0006355regulation of transcription, DNA-dependent IEA--

    EWSR1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    EWSR1 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for EWSR1 (EWS)

    1 HMDB Compound for EWSR1    About this table
    CompoundSynonyms CAS #PubMed Ids
    CalciumCa (see all 2)7440-70-2--

    10/11 Novoseek inferred chemical compound relationships for EWSR1 gene (see all 11)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    nor 1 72.9 8 11673470 (3), 18680143 (1), 16112421 (1)
    askin 71.9 1 12560386 (1)
    paraffin 35.6 3 16189150 (1), 15354743 (1), 10430278 (1)
    zinc 20.2 6 8522311 (1), 10074970 (1), 9795213 (1), 9354795 (1) (see all 6)
    tyrosine 0.575 5 9201297 (3), 8307570 (1), 17202261 (1)
    oligonucleotide 0 1 8238248 (1)
    cyclic amp 0 1 15150091 (1)
    arginine 0 2 15737635 (1), 15094065 (1)
    serine 0 1 8307570 (1)
    retinoic acid 0 1 12537770 (1)

    Search CenterWatch for drugs/clinical trials and news about EWSR1 / EWS

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for EWSR1 gene (5 alternative transcripts): 
    NM_001163285.1  NM_001163286.1  NM_001163287.1  NM_005243.3  NM_013986.3  

    Unigene Cluster for EWSR1:

    Ewing sarcoma breakpoint region 1
    Hs.374477  [show with all ESTs]
    Unigene Representative Sequence: BX648769
    18/21 Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 21):
    ENST00000444626 ENST00000397938(uc003aes.4 uc003aev.3 uc003aet.3 uc003aex.3 uc003aew.3 uc003aey.3)
    ENST00000436425 ENST00000447973 ENST00000485037 ENST00000406548 ENST00000437155
    ENST00000415761 ENST00000331029 ENST00000483415 ENST00000414183 ENST00000333395
    ENST00000455726 ENST00000332035 ENST00000493426 ENST00000479135(uc003aez.3)
    ENST00000469669 ENST00000483629
    Congresses - knowledge worth sharing:  
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

    miRNA
    Products:
         
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat EWSR1
    8/17 QIAGEN miScript miRNA Assays for microRNAs that regulate EWSR1 (see all 17):
    hsa-miR-1178 hsa-miR-136 hsa-miR-875-5p hsa-miR-548k hsa-miR-340 hsa-miR-29b-1* hsa-miR-299-5p hsa-miR-3688-3p
    SwitchGear 3'UTR luciferase reporter plasmidEWSR1 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for EWSR1
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat EWSR1
    Clone
    Products:
         
    OriGene clones in human, mouse for EWSR1 (see all 32)
    OriGene ORF clones in mouse, rat for EWSR1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 5): EWSR1 (NM_005243)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for EWSR1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat EWSR1
    Sirion Biotech Customized lentivirus for stable overexpression of EWSR1 
                         Customized lentivirus expression plasmids for stable overexpression of EWSR1 
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for EWSR1
    OriGene qSTAR qPCR primer pairs in human, mouse for EWSR1
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat EWSR1
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat EWSR1
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat EWSR1

    Additional mRNA sequence: 

    AK026270.1 AK056309.1 AK056681.1 AK096787.1 AK127624.1 AK225096.1 AK225102.1 AL833489.1 
    BC000527.2 BC004817.1 BC011048.1 BC072442.1 BX648769.1 CR456490.1 EU327511.1 FJ573261.1 
    JN624779.1 X66899.1 

    24/79 DOTS entries (see all 79):

    DT.86850959  DT.100850539  DT.95259529  DT.95177075  DT.92463886  DT.100804444  DT.100806295  DT.92463876 
    DT.97851466  DT.100687971  DT.100850943  DT.121359760  DT.100858739  DT.95259549  DT.100872006  DT.92463884 
    DT.91724771  DT.92463887  DT.100857431  DT.100840618  DT.100687992  DT.95359984  DT.100687985  DT.120631430 

    24/878 AceView cDNA sequences (see all 878):

    AA454643 BI086925 BM909485 BQ644095 CA425813 BE514686 BC000527 CA450030 
    BG388888 CB045629 BQ060973 BQ063273 BM928070 AI911646 CD369997 CR604639 
    CA448726 BU633967 AA301019 BQ015252 CB528364 BU501347 BI821599 CD517584 

    GeneLoc Exon Structure

    5/10 Alternative Splicing Database (ASD) splice patterns (SP) for EWSR1 (see all 10)    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9a · 9b ^ 10 ^ 11 ^ 12a · 12b · 12c ^ 13a · 13b ^ 14a · 14b · 14c ^ 15 ^ 16a · 16b
    SP1:                                                              -                                                                                       
    SP2:                                                              -                                                                                       
    SP3:                                                                                                                                                      
    SP4:                                                                                                                                                      
    SP5:                                                                                                                    -                                 


    ECgene alternative splicing isoforms for EWSR1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    EWSR1 expression in normal human tissues (normalized intensities)      EWSR1 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GACCGAGGTG
    EWSR1 Expression
    About this image


    EWSR1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/35 selected tissues (see all 35) fully expand
     
     Epithelium
             vagina ; squamous epithelial cells   
     
     Uterus
             uterus, post-menopause ; glandular cells   
     
     Testis (Reproductive System)    fully expand to see all 4 entries
             Leydig Cells Testis Interstitium
             seminal vesicle ; glandular cells   
     
     Brain (Nervous System)    fully expand to see all 4 entries
             Cerebral Cortex
     
     Colon (Gastrointestinal Tract)    fully expand to see all 3 entries
             rectum ; glandular cells   

    See EWSR1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for EWSR1

    SOURCE GeneReport for Unigene cluster: Hs.374477

    UniProtKB/Swiss-Prot: EWS_HUMAN, Q01844
    Tissue specificity: Ubiquitous

        SABiosciences Expression via Pathway-Focused PCR Array including EWSR1: 
              Tumor Metastasis in human mouse rat

    Primer
    Products:
    OriGene qPCR primer pairs and template standards for EWSR1
    OriGene qSTAR qPCR primer pairs in human, mouse for EWSR1
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat EWSR1
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat EWSR1
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat EWSR1
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for EWSR1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals and fungi.

    Orthologs for EWSR1 gene from 8/17 species (see all 17)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Ewsr11 , 5 Ewing sarcoma breakpoint region 11, 5 93.44(n)1
    97.86(a)1
      11 (3.22 cM)5
    140301  NM_007968.21  NP_031994.21 
     50696895 
    chicken
    (Gallus gallus)
    Aves EWSR11 Ewing sarcoma breakpoint region 1 72.08(n)
    75.39(a)
      417022  NM_001039267.1  NP_001034356.1 
    lizard
    (Anolis carolinensis)
    Reptilia EWSR16
    --
    --
    85(a)
    51(a)
    1 ↔ 1
    possible ortholog
    GL343417.1(98659-110655)
    GL343220.1(2260486-2273600)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.77052 Xenopus laevis, Similar to Ewing sarcoma breakpoint region 1, clone IMAGE5543106, mRNA less 77.94(n)    BC043904.1 
    zebrafish
    (Danio rerio)
    Actinopterygii wufc04c012 Danio rerio cDNA clone IMAGE6789697, partial cds 75.69(n)    BC056281.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta caz6
    CG147186
    (see all 3)
    --
    27(a)
    15(a)
    (see all 3)
    many ↔ many
    many ↔ many
    (see all 3)
    X(16182879-16187553)
    3R(7526336-7528442)
    worm
    (Caenorhabditis elegans)
    Secernentea fust-16
    F10E7.26
    (see all 3)
    Protein F10E7.2
    (see all 3)
    23(a)
    17(a)
    (see all 3)
    1 ↔ many
    possible ortholog
    (see all 3)
    II(7152566-7155474)
    II(7122242-7124401)
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes GAR16
    Protein component of the H/ACA snoRNP pseudouridyl...
    20(a)
    1 → many
    VIII(282681-283298)


    ENSEMBL Gene Tree for EWSR1 (if available)
    TreeFam Gene Tree for EWSR1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for EWSR1 gene
    TAF152  FUS2  
    5 SIMAP similar genes for EWSR1 using alignment to 10 protein entries:     EWS_HUMAN (see all proteins):
    EWSR1/ZNF384 fusion    EWSR1/ATF1 fusion    EWSR1/FLI1 fusion    FUS    TAF15

    EWSR1 for paralogs           About GeneDecksing


    2 Pseudogenes.org Pseudogenes for EWSR1
    PGOHUM00000258792 PGOHUM00000244322


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/828 SNPs in EWSR1 are shown (see all 828)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 22 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs579833441,2
    C,F--13584009(+) CACAGC/GCCCTC 5 -- us2k12Minor allele frequency- G:0.09WA 120
    rs1139116331,2
    C,F--13584015(+) CCCTCT/CGGCCC 5 -- us2k12Minor allele frequency- C:0.12CSA WA 120
    rs1871855991,2
    --13584054(+) GTATGC/TGCTCC 5 -- us2k10--------
    rs1174746931,2
    C,F--13584117(+) GATGAG/ACCTCA 5 -- us2k11Minor allele frequency- A:0.03NA 120
    rs622260821,2
    C,F--13584186(+) CTCAGG/AGTATG 5 -- us2k11Minor allele frequency- A:0.50NA 2
    rs1911953471,2
    --13584280(+) CAGGCA/GTCTGT 5 -- us2k10--------
    rs1120041801,2
    F--13584413(+) GTGCTG/CTTCTC 5 -- us2k11Minor allele frequency- C:0.50CSA 2
    rs1837485751,2
    --13584415(+) GCTGTC/TCTCTT 5 -- us2k10--------
    rs770786851,2
    F--13584634(+) TTCCCT/CCCATT 5 -- us2k11Minor allele frequency- C:0.01NA 120
    rs1889229301,2
    --13584743(+) GCACAC/GCTTGG 5 -- us2k10--------

    HapMap Linkage Disequilibrium report for EWSR1 (29663998 - 29696515 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 9 variations for EWSR1:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2724123CNV Deletion23290073
    esv2169204CNV Deletion18987734
    esv991613CNV Deletion20482838
    esv2669638CNV Deletion23128226
    esv21927CNV Loss19812545
    nsv834171CNV Loss17160897
    dgv4951n71CNV Loss21882294
    nsv829155CNV Loss20364138
    nsv829154CNV Gain20364138


    Human Gene Mutation Database (HGMD): EWSR1
    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing EWSR1
    DNA2.0 Custom Variant and Variant Library Synthesis for EWSR1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 133450   
    OMIM disorders: 612219  
    UniProtKB/Swiss-Prot: EWS_HUMAN, Q01844
  • Ewing sarcoma (ES) [MIM:612219]: A highly malignant, metastatic, primitive small round cell tumor of bone
    and soft tissue that affects children and adolescents. It belongs to the Ewing sarcoma family of tumors, a group
    of morphologically heterogeneous neoplasms that share the same cytogenetic features. They are considered neural
    tumors derived from cells of the neural crest. Ewing sarcoma represents the less differentiated form of the
    tumors. Note=The disease is caused by mutations affecting the gene represented in this entry. Chromosomal
    aberrations involving EWSR1 are found in patients with Ewing sarcoma. Translocation t(11;22)(q24;q12) with FLI1;
    translocation t(7;22)(p22;q12) with ETV1; translocation t(21;22)(q22;q12) with ERG; translocation
    t(9;22)(q22-31;q11-12) with NR4A3. Translocation t(2;21;22)(q23;q22;q12) that forms a EWSR1-FEV fusion protein
    with potential oncogenic activity
  • Note=A chromosomal aberration involving EWSR1 is associated with desmoplastic small round cell tumor
    (DSRCT). Translocation t(11;22)(p13;q12) with WT1
  • Note=A chromosomal aberration involving EWSR1 is associated with malignant melanoma of soft parts (MMSP).
    Translocation t(12;22)(q13;q12) with ATF-1. Malignant melanoma of soft parts, also known as soft tissue clear
    cell sarcoma, is a rare tumor developing in tendons and aponeuroses
  • Note=A chromosomal aberration involving EWSR1 is associated with small round cell sarcoma. Translocation
    t(11;22)(p36.1;q12) with PATZ1
  • Angiomatoid fibrous histiocytoma (AFH) [MIM:612160]: A distinct variant of malignant fibrous histiocytoma
    that typically occurs in children and adolescents and is manifest by nodular subcutaneous growth. Characteristic
    microscopic features include lobulated sheets of histiocyte-like cells intimately associated with areas of
    hemorrhage and cystic pseudovascular spaces, as well as a striking cuffing of inflammatory cells, mimicking a
    lymph node metastasis. Note=The disease may be caused by mutations affecting the gene represented in this entry.
    Chromosomal aberrations involving EWSR1 are found in patients with angiomatoid fibrous histiocytoma.
    Translocation t(12;22)(q13;q12) with ATF1 generates a chimeric EWSR1/ATF1 protein. Translocation t(2;22)(q33;q12)
    with CREB1 generates a EWSR1/CREB1 fusion gene that is most common genetic abnormality in this tumor type
  • Note=EFPS arise due to chromosomal translocations in which EWSR1 is fused to a variety of cellular
    transcription factors. EFPS are very potent transcriptional activators dependent on the EAD and a C-terminal
    DNA-binding domain contributed by the fusion partner. The spectrum of malignancies associated with EFPS are
    thought to arise via EFP-induced transcriptional deregulation, with the tumor phenotype specified by the EWSR1
    fusion partner and cell type. Transcriptional repression of the transforming growth factor beta type II receptor
    (TGF beta RII) is an important target of the EWS-FLI1, EWS-ERG, or EWS-ETV1 oncogene

  • 20/51 diseases for EWSR1 (see all 51):    About MalaCards
    ewing's family of tumors    melanoma of soft part    localized ewing's sarcoma    connective tissue benign neoplasm
    neuroepithelioma    desmoplastic small round cell tumor    myxoid chondrosarcoma    clear cell sarcoma
    extraskeletal myxoid chondrosarcoma    peripheral primitive neuroectodermal tumor    sarcoma    extraosseous ewing's sarcoma
    nervous system cancer    central nervous system cancer    myxoid liposarcoma    myoepithelial carcinoma
    primitive neuroectodermal tumor    liposarcoma    olfactory neuroblastoma    chondrosarcoma

    12 diseases from the University of Copenhagen DISEASES database for EWSR1:
    Peripheral primitive neuroectodermal tumor     Sarcoma     Primitive neuroectodermal tumor     Chondrosarcoma
    Liposarcoma     Fibrous histiocytoma     Rhabdomyosarcoma     Synovial sarcoma
    Myoepithelioma     Bone cancer     Connective tissue benign neoplasm     Nephroblastoma

    EWSR1 for disorders           About GeneDecksing

    10/24 Novoseek inferred disease relationships for EWSR1 gene (see all 24)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    ewings sarcoma 96.3 155 12907633 (4), 9121764 (4), 12522555 (4), 16837212 (3) (see all 99)
    sarcoma clear cell 87.3 20 16258500 (5), 8187063 (2), 17000668 (1), 7493135 (1) (see all 15)
    liposarcoma myxoid 83.8 7 19190116 (1), 7493135 (1), 8187069 (1), 8954779 (1) (see all 6)
    peripheral neuroepithelioma 83.6 2 19725831 (1), 15735862 (1)
    primitive neuroectodermal tumor pnet 79.4 1 10623711 (1)
    desmoplastic small round-cell tumor 78.3 2 10912946 (1), 10430278 (1)
    sarcoma 74.5 34 18162764 (3), 18580682 (3), 17912356 (2), 8834175 (2) (see all 24)
    chondrosarcoma 70.8 23 18162764 (3), 7539287 (3), 18580682 (2), 8570200 (2) (see all 15)
    sarcoma extraosseous ewings 67.4 1 8605035 (1)
    neuroectodermal tumors 64.3 2 8307570 (1), 16046110 (1)


    Export disorders for EWSR1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for EWSR1 gene, integrated from 9 sources (see all 419):
    (articles sorted by number of sources associating them with EWSR1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Gene fusion with an ETS DNA-binding domain caused by chromosome translocation in human tumours. (PubMed id 1522903)1, 2, 3 Delattre O.... Thomas G. (1992)
    2. The EWS gene, involved in Ewing family of tumors, malignant melanoma of soft parts and desmoplastic small round cell tumors, codes for an RNA binding protein with novel regulatory domains. (PubMed id 8084618)1, 2, 9 Ohno T.... Reddy E.S.P. (1994)
    3. The transcriptional repressor ZFM1 interacts with and modulates the ability of EWS to activate transcription. (PubMed id 9660765)1, 2, 9 Zhang D.... Childs G. (1998)
    4. Transcriptional activation by the Ewing's sarcoma (EWS) oncogene can be cis-repressed by the EWS RNA-binding domain. (PubMed id 10767297)1, 2, 9 Li K.K.C. and Lee K.A.W. (2000)
    5. The prooncoprotein EWS binds calmodulin and is phosphorylated by protein kinase C through an IQ domain. (PubMed id 9341188)1, 2, 9 Deloulme J.C.... Storm D.R. (1997)
    6. Genomic structure of the EWS gene and its relationship to EWSR1, a site of tumor-associated chromosome translocation. (PubMed id 8307570)1, 2, 9 Plougastel B.... Delattre O. (1993)
    7. Molecular analysis of a t(11;22) translocation junction in a case of Ewing's sarcoma. (PubMed id 7542907)1, 2, 9 Bhagirath T.... Yoshida M.C. (1995)
    8. Fusion of the EWSR1 and ATF1 genes without expression of the MITF-M transcript in angiomatoid fibrous histiocytoma. (PubMed id 15884099)1, 2, 9 Hallor K.H.... Panagopoulos I. (2005)
    9. Exposure on cell surface and extensive arginine methylation of Ewing sarcoma (EWS) protein. (PubMed id 11278906)1, 2, 9 Belyanskaya L.L.... Gehring H. (2001)
    10. TDRD3, a novel Tudor domain-containing protein, localizes to cytoplasmic stress granules. (PubMed id 18632687)1, 2 Goulet I.... Cote J. (2008)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 2130 HGNC: 3508 AceView: EWSR1andGAS2L1 Ensembl:ENSG00000182944 euGenes: HUgn2130
    ECgene: EWSR1 Kegg: 2130 H-InvDB: EWSR1

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for EWSR1 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for EWSR1 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for EWSR1 gene:
    Search GeneIP for patents involving EWSR1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

     
     EMD Millipore Custom Antibody & Bulk Services
     EMD Millipore Preclinical / Clinical Development Services
     EMD Millipore Immunoassay Services
     EMD Millipore Target Screening & Profiling Services

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
     Browse ELISpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Multiplex/Array Assay Kits/Reagents  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Protease Activity Assays and Reagents   Browse Recombinant/Natural Proteins  
     Browse Stem Cell Products   Browse Tocris Biochemicals & Compounds  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     OriGene Antibodies for EWSR1   OriGene RNAi products in human, mouse, rat for EWSR1  
     OriGene qPCR primer pairs and template standards for EWSR1   OriGene Protein Over-expression Lysate for EWSR1  
     OriGene MassSpec something-or-other for EWSR1   OriGene clones in human, mouse for EWSR1  
     OriGene qSTAR qPCR primer pairs in human, mouse for EWSR1   OriGene Purified Protein for EWSR1  
     OriGene ORF clones in mouse, rat for EWSR1   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for EWSR1   OriGene Custom Protein Services for EWSR1  

     
     
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat EWSR1
     QIAGEN SeqTarget long-range PCR primers for resequencing EWSR1
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat EWSR1
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat EWSR1
     QIAGEN QuantiFast Probe-based Assays in human, mouse, rat EWSR1
     QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat EWSR1
     GenScript Custom Purified and Recombinant Proteins Services for EWSR1 GenScript cDNA clones with any tag delivered in your preferred vector for EWSR1
     GenScript Custom Assay Services for EWSR1 GenScript Custom Superior Antibodies Services for EWSR1
     GenScript Custom overexpressing Cell Line Services for EWSR1 CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Antibodies & Assays for EWSR1  (EWS)

     Regulatory tfbs in EWSR1 promoter
     Search Chromatin IP Primers for EWSR1
     RT2 qPCR Primer Assay in human, mouse, rat EWSR1
     GNC Network for EWSR1
     SABiosciences PCR Arrays including human, mouse, rat EWSR1
     Search Tocris compounds for EWSR1 (EWS)
     Browse Sino Biological Proteins and Antibodies
     Browse Sino Biological Cell Lysates
     Browse Sino Biological cDNA Clones
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     EWSR1 antibodies
     EWSR1 proteins
     EWSR1 lysates
     Antibodies for EWSR1
     See all of Abcam's Antibodies, Kits and Proteins for EWSR1
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins




     Proteins for EWSR1
     Antibodies for EWSR1
     ELISAs for EWSR1
     CLIAs for EWSR1
     Search LifeMap BioReagents cell lines for EWSR1
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for EWSR1
     SwitchGear 3'UTR luciferase reporter plasmids for EWSR1
     SwitchGear Promoter luciferase reporter plasmids for EWSR1
     ThermoFisher Antibody for EWSR1
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat EWSR1
     inGenious Targeting Laboratory - Custom generated mouse model solutions for EWSR1
     inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for EWSR1
    Customized:
     lentivirus for stable overexpression of EWSR1
     lentivirus expression plasmids for stable overexpression of EWSR1
     adenovirus for overexpression of EWSR1
     LSBio Antibodies in human, mouse, rat for EWSR1
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
           
    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

    View Random Gene

    Category
    (GIFtS: 73)
    transforming growth factor, beta 1
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      EWSR1 gene at Home site.
    hostname: 356980-web2.xennexinc.com index build: 106 solr: 1.4