Free for academic non-profit institutions. Other users need a Commercial license

Aliases for EVX2 Gene

Aliases for EVX2 Gene

  • Even-Skipped Homeobox 2 2 3
  • EVX-2 3 4
  • Even-Skipped Homeo Box 2 (Homolog Of Drosophila Eve) 3
  • Eve, Even-Skipped Homeobox Homolog 2 (Drosophila) 2
  • Homeobox Even-Skipped Homolog Protein 2 3
  • Eve, Even-Skipped Homeo Box Homolog 2 3

External Ids for EVX2 Gene

Previous GeneCards Identifiers for EVX2 Gene

  • GC02U990026
  • GC02M175605
  • GC02M176908
  • GC02M177147
  • GC02M176770
  • GC02M176653
  • GC02M168822

Summaries for EVX2 Gene

Entrez Gene Summary for EVX2 Gene

  • This gene is located at the 5' end of the HOXD gene cluster on chromosome 2. The encoded protein is a homeobox transcription factor that is related to the protein encoded by the Drosophila even-skipped (eve) gene, a member of the pair-rule class of segmentation genes. A 117 kb microdeletion at the 5' end of the HOXD gene cluster, which includes this gene and the HOXD9-HOXD13 genes, causes synpolydactyly, a dominantly inherited disease resulting in limb malformation. [provided by RefSeq, Sep 2009]

GeneCards Summary for EVX2 Gene

EVX2 (Even-Skipped Homeobox 2) is a Protein Coding gene. Diseases associated with EVX2 include synpolydactyly. GO annotations related to this gene include sequence-specific DNA binding transcription factor activity and sequence-specific DNA binding. An important paralog of this gene is EVX1.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for EVX2 Gene

Genomics for EVX2 Gene

Regulatory Elements for EVX2 Gene

Genomic Location for EVX2 Gene

176,077,472 bp from pter
176,083,962 bp from pter
6,491 bases
Minus strand

Genomic View for EVX2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for EVX2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for EVX2 Gene

Proteins for EVX2 Gene

  • Protein details for EVX2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Homeobox even-skipped homolog protein 2
    Protein Accession:
    Secondary Accessions:

    Protein attributes for EVX2 Gene

    476 amino acids
    Molecular mass:
    47800 Da
    Quaternary structure:
    No Data Available

neXtProt entry for EVX2 Gene

Proteomics data for EVX2 Gene at MOPED

Post-translational modifications for EVX2 Gene

No Post-translational modifications

Other Protein References for EVX2 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for EVX2 Gene

Domains for EVX2 Gene

Gene Families for EVX2 Gene

  • HOXL :Homeoboxes / ANTP class : HOXL subclass

Suggested Antigen Peptide Sequences for EVX2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Q03828
  • Contains 1 homeobox DNA-binding domain.
  • Belongs to the even-skipped homeobox family.
genes like me logo Genes that share domains with EVX2: view

Function for EVX2 Gene

Molecular function for EVX2 Gene

GENATLAS Biochemistry:
Drosophila even-skipped pair rule gene homolog 2 (murine Evx2),homeo domain encoding gene,expressed in limbs

Gene Ontology (GO) - Molecular Function for EVX2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding --
GO:0043565 sequence-specific DNA binding IEA --
genes like me logo Genes that share ontologies with EVX2: view
genes like me logo Genes that share phenotypes with EVX2: view

Animal Models for EVX2 Gene

MGI Knock Outs for EVX2:

Animal Model Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for EVX2

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , miRNA , Transcription Factor Targeting and HOMER Transcription for EVX2 Gene

Localization for EVX2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for EVX2 Gene

Subcellular locations from

Jensen Localization Image for EVX2 Gene COMPARTMENTS Subcellular localization image for EVX2 gene
Compartment Confidence
nucleus 5

Gene Ontology (GO) - Cellular Components for EVX2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus --
GO:0005654 nucleoplasm IDA --
genes like me logo Genes that share ontologies with EVX2: view

Pathways for EVX2 Gene

SuperPathways for EVX2 Gene

No Data Available

Interacting Proteins for EVX2 Gene

Gene Ontology (GO) - Biological Process for EVX2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0008150 biological_process ND --
GO:0035108 limb morphogenesis IEA --
genes like me logo Genes that share ontologies with EVX2: view

No data available for Pathways by source for EVX2 Gene

Transcripts for EVX2 Gene

mRNA/cDNA for EVX2 Gene

(0) Additional mRNA sequences :
(2) REFSEQ mRNAs :
(1) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for EVX2 Gene

Even-skipped homeobox 2:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for EVX2

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for EVX2 Gene

No ASD Table

Relevant External Links for EVX2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for EVX2 Gene

mRNA expression in normal human tissues for EVX2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for EVX2 Gene

This gene is overexpressed in Testis (17.4), Cervix - Ectocervix (10.2), Vagina (7.7), Colon - Sigmoid (6.3), and Cervix - Endocervix (5.7).

Protein differential expression in normal tissues for EVX2 Gene

This gene is overexpressed in Heart (68.3).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for EVX2 Gene

SOURCE GeneReport for Unigene cluster for EVX2 Gene Hs.452341

genes like me logo Genes that share expressions with EVX2: view

Expression partners for EVX2 Gene

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for EVX2 Gene

Orthologs for EVX2 Gene

This gene was present in the common ancestor of animals.

Orthologs for EVX2 Gene

Organism Taxonomy Gene Similarity Type Details
(Canis familiaris)
Mammalia EVX2 35
  • 90.27 (n)
  • 94.5 (a)
EVX2 36
  • 96 (a)
(Mus musculus)
Mammalia Evx2 35
  • 86.16 (n)
  • 91.74 (a)
Evx2 16
Evx2 36
  • 95 (a)
(Pan troglodytes)
Mammalia EVX2 35
  • 99.44 (n)
  • 99.79 (a)
EVX2 36
  • 100 (a)
(Rattus norvegicus)
Mammalia Evx2 35
  • 88.66 (n)
  • 92.51 (a)
(Monodelphis domestica)
Mammalia EVX2 36
  • 91 (a)
(Gallus gallus)
Aves EVX2 35
  • 76.81 (n)
  • 72.58 (a)
EVX2 36
  • 63 (a)
(Anolis carolinensis)
Reptilia EVX2 36
  • 66 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia evx2 35
  • 69.42 (n)
  • 72.81 (a)
(Danio rerio)
Actinopterygii evx2 35
  • 67.62 (n)
  • 72.73 (a)
evx2 36
  • 78 (a)
fruit fly
(Drosophila melanogaster)
Insecta eve 37
  • 71 (a)
eve 36
  • 31 (a)
(Caenorhabditis elegans)
Secernentea vab-7 36
  • 33 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 33 (a)
Species with no ortholog for EVX2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for EVX2 Gene

Gene Tree for EVX2 (if available)
Gene Tree for EVX2 (if available)

Paralogs for EVX2 Gene

Selected SIMAP similar genes for EVX2 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with EVX2: view

Variants for EVX2 Gene

Sequence variations from dbSNP and Humsavar for EVX2 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type MAF
rs847142 -- 176,079,968(-) CCGAA(A/G)GGAAC downstream-variant-500B
rs1868101 -- 176,080,284(-) ggcgg(C/T)ggtgg reference, synonymous-codon
rs6758117 -- 176,082,509(+) GCTGG(C/T)GCTGC intron-variant
rs10209263 -- 176,084,523(+) GAGAA(A/G)ACCTT upstream-variant-2KB
rs12104464 -- 176,085,606(+) TGGGC(A/G)CGGGT upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for EVX2 Gene

Variant ID Type Subtype PubMed ID
nsv520227 CNV Loss 19592680
dgv676n67 CNV Gain 20364138
nsv875437 CNV Loss 21882294
nsv875438 CNV Loss 21882294
nsv527187 CNV Loss 19592680
nsv517968 CNV Loss 19592680
dgv4368n71 CNV Loss 21882294

Relevant External Links for EVX2 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for EVX2 Gene

Disorders for EVX2 Gene

MalaCards: The human disease database

MalaCards: The human disease database.

Search for EVX2 Gene in MalaCards »

(1) Diseases for EVX2 Gene including...

(1) University of Copenhagen DISEASES for EVX2 Gene

genes like me logo Genes that share disorders with EVX2: view

No data available for OMIM , UniProtKB/Swiss-Prot , Novoseek inferred disease relationships , Genatlas and External Links for EVX2 Gene

Publications for EVX2 Gene

  1. EVX2, a human homeobox gene homologous to the even-skipped segmentation gene, is localized at the 5' end of HOX4 locus on chromosome 2. (PMID: 1675198) D'Esposito M. … Boncinelli E. (Genomics 1991) 2 3 4
  2. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PMID: 15815621) Hillier L.W. … Wilson R.K. (Nature 2005) 3 4
  3. Toward a confocal subcellular atlas of the human proteome. (PMID: 18029348) Barbe L. … Andersson-Svahn H. (Mol. Cell Proteomics 2008) 3
  4. Genome-wide association study of periodontal pathogen colonization. (PMID: 22699663) Divaris K. … Offenbacher S. (J. Dent. Res. 2012) 3
  5. Localization of the syndactyly type II (synpolydactyly) locus to 2q31 region and identification of tight linkage to HOXD8 intragenic marker. (PMID: 7581388) Sarfarazi M. … Sayli B.S. (Hum. Mol. Genet. 1995) 3

Products for EVX2 Gene

Sources for EVX2 Gene

Back to Top