EVX2 Gene
protein-coding GIFtS : 41
GCID: GC02 M176908
even-skipped homeobox 2 (Previous names: eve, even-skipped homeobox homolog 2 (Drosophila) )
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Aliasesfor EVX2 gene
(According to
1 HGNC ,
2 Entrez Gene ,
3 UniProtKB/Swiss-Prot ,
4 UniProtKB/TrEMBL , 5 OMIM , 6 GeneLoc ,
7 Ensembl ,
8 DME ,
9 miRBase ,
and/or 10 fRNAdb )About This Section Aliases Even-Skipped Homeobox 2 1 2 EVX-22 3 Eve, Even-Skipped Homeobox Homolog 2 (Drosophila)1 Eve, Even-Skipped Homeo Box Homolog 22 Even-Skipped Homeo Box 2 (Homolog Of Drosophila Eve)2 Homeobox Even-Skipped Homolog Protein 22
Export aliases for EVX2 gene to outside databases Previous GC identifers: GC02U990026 GC02M175605 GC02M177147 GC02M176770 GC02M176653 GC02M168822
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Summariesfor EVX2 gene (According to Entrez Gene ,
Tocris Bioscience ,
Wikipedia's
Gene Wiki ,
PharmGKB ,
UniProtKB/Swiss-Prot ,
and/or
UniProtKB/TrEMBL )
About This Section Entrez Gene summary for EVX2 : This gene is located at the 5' end of the HOXD gene cluster on chromosome 2. The encoded protein is a homeobox transcription factor that is related to the protein encoded by the Drosophila even-skipped (eve) gene, a member of the pair-rule class of segmentation genes. A 117 kb microdeletion at the 5' end of the HOXD gene cluster, which includes this gene and the HOXD9-HOXD13 genes, causes synpolydactyly, a dominantly inherited disease resulting in limb malformation. (provided by RefSeq, Sep 2009)
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Genomic Viewsfor EVX2 gene
(According to
GeneLoc and/or
HGNC , and/or
Entrez Gene (NCBI build 37) ,
and/or miRBase ,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69) ,
Regulatory elements and Epigenetics data according to
QIAGEN ,
SABiosciences , and/or
SwitchGear Genomics )About This Section RefSeq DNA sequence: NC_000002.11 NC_018913.1 NT_005403.17 Regulatory elements: SABiosciences Regulatory transcription factor binding sites in the EVX2 gene promoter: TBP PPAR-gamma1 AP-1 ATF-2 c-Jun PPAR-gamma2 Other transcription factors Search SABiosciences Chromatin IP Primers for EVX2 Epigenetics: QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat EVX2
Genomic Location: Genomic View : UCSC Golden Path with GeneCards custom track Entrez Gene cytogenetic band: 2q31.1 Ensembl cytogenetic band: 2q31.1 HGNC cytogenetic band: 2q31.1 EVX2 Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different) GeneLoc information about chromosome 2 GeneLoc Exon Structure
GeneLoc location for GC02M176908: view genomic region
(about GC identifiers )
Start:
176,942,200 bp from pter
End:
176,948,690 bp from pter
Size:
6,491 bases
Orientation:
minus strand
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Proteinsfor EVX2 gene
(According to
1 UniProtKB ,
HORDE ,
neXtProt ,
Ensembl ,
and/or Reactome ,
Modification sites according to 2 PhosphoSitePlus ,
Specific Peptides from DME ,
Protein expression images according to data from SPIRE MOPED and PaxDb ,
RefSeq according to NCBI ,
PDB rendering according to OCA and/or Proteopedia ,
Recombinant Proteins
from
EMD Millipore ,
R&D Systems ,
GenScript ,
Enzo Life Sciences ,
OriGene ,
Novus Biologicals ,
Sino Biological ,
ProSpec , and/or
Uscn ,
Biochemical Assays by
EMD Millipore ,
R&D Systems ,
OriGene ,
GenScript ,
Cell Signaling Technology ,
Enzo Life Sciences , and/or
Uscn ,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene ,
Antibodies by
EMD Millipore ,
R&D Systems ,
GenScript ,
Cell Signaling Technology ,
OriGene ,
Novus Biologicals ,
Thermo Fisher Scientific ,
Abcam , and/or
Uscn )
About This Section UniProtKB/Swiss-Prot: EVX2_HUMAN, Q03828 (See
protein sequence )Recommended Name: Homeobox even-skipped homolog protein 2 Size : 476 amino acids; 47800 Da
Subcellular location : Nucleus
Developmental stage : Expressed during early embryogenesis and neurogenesis in a biphasic mannerExplore the universe of human proteins at neXtProt for EVX2: NX_Q03828 EVX2 Protein expression data from MOPED and PaxDb : About this image
REFSEQ proteins: NP_001073927.1 ENSEMBL proteins: ENSP00000312385 Human Recombinant Protein Products: Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view) : About this table
EVX2 for ontologies About GeneDecksing EVX2 Antibody Products: Assay Products for EVX2:
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Protein
Domains / Familiesfor EVX2 gene (According to InterPro , ProtoNet ,
UniProtKB , and/or BLOCKS ,
Sets of similar genes according to GeneDecks )
About This Section
EVX2 for domains About GeneDecksing 4 InterPro domains/families :
Graphical View of Domain Structure for InterPro Entry Q03828 ProtoNet protein and cluster: Q03828
1 Blocks protein family : IPB000047 Lambda and other repressor helix-turn-helix signature UniProtKB/Swiss-Prot: EVX2_HUMAN, Q03828 Similarity : Belongs to the even-skipped homeobox familySimilarity : Contains 1 homeobox DNA-binding domain
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Functionfor EVX2 gene
(According to 1 UniProtKB ,
Genatlas ,
LifeMap Discovery™ ,
IUBMB , and/or
2 DME ,
Human phenotypes from GenomeRNAi ,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences ,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene ,
RNAi from
EMD Millipore ,
siRNAs from
OriGene ,
QIAGEN ,
microRNA from QIAGEN ,
Gene Editing from DNA2.0 ,
Clones from EMD Millipore ,
OriGene ,
SwitchGear Genomics ,
GenScript ,
Sino Biological ,
DNA2.0 ,
and Vector BioLabs ,
Cell Lines from GenScript ,
LifeMap BioReagents ,
In Situ Hybridization Assays from Advanced Cell Diagnostics ,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene .)
About This Section Function Summary: Genatlas biochemistry entry for EVX2 : Drosophila even-skipped pair rule gene homolog 2 (murine Evx2),homeo domain encoding gene,expressed in limbs Clone Products: Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human , mouse , rat for EVX2 (see all 3 ) OriGene untagged cDNA clones in CMV expression vector in human , mouse , rat for EVX2OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling GenScript: all cDNA clones in your preferred vector: EVX2 (NM_001080458 ) Browse Sino Biological Human cDNA Clones DNA2.0 Custom Codon Optimized Gene
Synthesis Service for EVX2 Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat EVX2
In Situ Assay Products: Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for EVX2
Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view) : About this table
GO ID Qualified GO term Evidence PubMed IDs GO:0003677 DNA binding
NAS -- GO:0003700 sequence-specific DNA binding transcription factor activity
IEA -- GO:0043565 sequence-specific DNA binding
IEA --
EVX2 for ontologies About GeneDecksing Animal Models: Mouse knock-outs for EVX2: Evx2/Hoxd13 Evx2/tm3.1Ddu Evx2 tm1Ddu Evx2/Hoxd13 Evx2/tm2Ddu Evx2/Hoxd11/Hoxd12/Hoxd13 Evx2/Hoxd11/Hoxd12/tm1Ddu Evx2/Hoxd13 Evx2/tm3Ddu Evx2/Hoxd13 Evx2/tm1Ddu 8 MGI mutant phenotypes (inferred from 9 alleles ) (MGI details for Evx2) :
EVX2 for phenotypes About GeneDecksing
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Pathways & Interactionsfor EVX2 gene
(Pathways according to
EMD Millipore ,
R&D Systems ,
Cell Signaling Technology ,
KEGG ,
PharmGKB ,
BioSystems ,
Reactome ,
Tocris Bioscience ,
GeneGo (Thomson Reuters) ,
QIAGEN ,
and/or UniProtKB ,
Sets of similar genes according to GeneDecks ,
Interaction Networks according to
SABiosciences ,
and/or STRING ,
Interactions according to 1 UniProtKB ,
2 MINT ,
3 I2D , and/or
4 STRING ,
with links to IntAct and
Ensembl ,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene) .
About This Section Interactions: Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for EVX2 Gene Ontology (GO): 2 biological process terms (GO ID links to tree view) : About this table
GO ID Qualified GO term Evidence PubMed IDs GO:0008150 biological_process
ND -- GO:0035108 limb morphogenesis
IEA --
EVX2 for ontologies About GeneDecksing
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Drugs & Compoundsfor EVX2 gene (Chemical Compounds according to UniProtKB , Enzo Life Sciences ,
EMD Millipore , Tocris Bioscience
HMDB ,
BitterDB , and/or
Novoseek , and Drugs according to
DrugBank ,
Enzo Life Sciences , and/or
PharmGKB , with drugs/clinical trials/news
search links to CenterWatch )
About This Section Browse Tocris compounds for EVX2 Search CenterWatch for drugs/clinical trials and news about EVX2
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Transcriptsfor EVX2 gene (Secondary structures according to
fRNAdb ,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank , RefSeq according to Entrez Gene ,
DOTS (version 10), and/or
AceView ,
transcript ids from Ensembl
with links to UCSC ,
exon structure from GeneLoc ,
alternative splicing isoforms according to ASD and/or
ECgene ,
RNAi Products from
EMD Millipore ,
siRNAs from
OriGene ,
QIAGEN ,
shRNA from
OriGene ,
microRNA from QIAGEN ,
Tagged/untagged cDNA clones from
OriGene ,
SwitchGear Genomics ,
GenScript ,
DNA2.0 ,
Vector BioLabs ,
Primers from
OriGene ,
SABiosciences , and/or
QIAGEN
)About This Section REFSEQ mRNAs for EVX2 gene: NM_001080458.1 Unigene Cluster for EVX2:
Even-skipped homeobox 2 Hs.452341 [show with all ESTs ] Unigene Representative Sequence: NM_001080458 1 Ensembl transcript including schematic representation, and UCSC links where relevant : ENST00000308618 (uc010zeu.2 ) Clone Products: OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human , mouse , rat for EVX2 (see all 3 ) OriGene untagged cDNA clones in CMV expression vector in human , mouse , rat for EVX2OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling GenScript: all cDNA clones in your preferred vector: EVX2 (NM_001080458 ) DNA2.0 Custom Codon Optimized Gene
Synthesis Service for EVX2 Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat EVX2
1 DOTS entry : DT.91921632
1 AceView cDNA sequence :
BF057568 GeneLoc Exon Structure
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Expression for EVX2 gene
(RNA expression data according to
H-InvDB ,
NONCODE ,
miRBase , and
RNAdb ,
Expression images according to data from
BioGPS ,
Illumina Human BodyMap , and
CGAP
SAGE ,
Sets of similar genes according to GeneDecks ,
in vivo and in vitro expression data from LifeMap Discovery™ ,
plus additional links to
Genevestigator , and/or
SOURCE , and/or
BioGPS , and/or
UniProtKB ,
PCR Arrays from
SABiosciences ,
Primers from
OriGene ,
SABiosciences , and/or
QIAGEN ,
In Situ Hybridization Assays from Advanced Cell Diagnostics )
About This Section EVX2 expression in normal human tissues (normalized intensities) See probesets specificity/sensitivity at GeneAnnot About this image BioGPS CGAP TAG: ATGACGCACG
About this image EVX2 expression in embryonic tissues and stem cells Expression by the Database of Embryonic development, Stem cell research, and
Regenerative medicine About this table 1 LifeMap In Vivo Development Anatomical Compartment/Cell Tissue Anatomical Compartment
Cell Category (developmental path) Spinal Cord V0 Neural Progenitor Domain V0 Interneurons Motor Neurons Expression: Positive Negative
Selective markerExperimental details:
Curated
Microarrays
In-situ hybridization
See EVX2 Protein Expression from SPIRE MOPED and PaxDB SOURCE GeneReport for Unigene cluster: Hs.452341 SABiosciences Custom PCR Arrays for EVX2 Primer Products: OriGene genome-wide validated SYBR primer pairs in human , mouse , rat for EVX2Browse OriGene validated miRNA SYBR primer pairs SABiosciences RT2 qPCR Primer Assay in human , mouse , rat EVX2 QIAGEN QuantiTect SYBR Green Assays in human , mouse , rat EVX2 QIAGEN QuantiFast Probe-based Assays in human , mouse , rat EVX2 In Situ Assay Products: Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for EVX2
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Orthologsfor EVX2 gene
(Orthologs according to
1,2 HomoloGene (2 older version, for species not in 1 newer version),
3 euGenes ,
4 SGD
,
5 MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase ,
and/or
6 Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam )
About This Section
This gene was present in the common ancestor of animals.
Orthologs for EVX2 gene from 6/16 species (see all 16 ) About this table
Organism
Taxonomic classification
Gene
Description
Human Similarity
Orthology Type
Details
mouse (Mus musculus)
Mammalia
Evx21 , 5
even skipped homeotic gene 2 homolog1, 5
88.35(n) 1 95.13(a) 1
 
2 (44.13 cM) 5 14029 1 NM_007967.2 1 NP_031993.1 1 74652997 5
chicken (Gallus gallus)
Aves
EVX26
Uncharacterized protein
49(a)
1 ↔ 1
7(17444164-17447372)
lizard (Anolis carolinensis)
Reptilia
EVX26
--
61(a)
1 ↔ 1
GL343356.1(628378-632437)
zebrafish (Danio rerio)
Actinopterygii
evx22
even-skipped homeobox 2
76.28(n)
 
30479 NM_131232.1
fruit fly (Drosophila melanogaster)
Insecta
eve3
blastoderm segmentation specific RNA polymerase more
71(a)
 
46C10 --
worm (Caenorhabditis elegans)
Secernentea
vab-76
Homeobox protein vab-7
33(a)
1 → many
III(10920237-10925942)
ENSEMBL Gene Tree for EVX2 (if available)TreeFam Gene Tree for EVX2 (if available)
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Paralogsfor EVX2 gene (Paralogs according to
1 HomoloGene , 2 Ensembl , and 3 SIMAP , Pseudogenes according to 4 Pseudogene.org Build 68)About This Section Paralogs for EVX2 gene NKX1-2 2 MEOX1 2 EVX1 2 MNX1 2 MEOX2 2 NKX1-1 2 GBX1 2 GBX2 2 1 SIMAP similar gene for EVX2 using alignment to 1 protein entry: EVX2_HUMAN :EVX1
EVX2 for paralogs About GeneDecksing
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Genomic Variantsfor EVX2 gene (SNPs/Variants according to the
1 NCBI SNP Database ,
2 Ensembl ,
3 PupaSUITE ,
UniProtKB , and
DNA2.0 ,
Linkage Disequilibrium by HapMap ,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants , Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB) , Blood group antigen gene mutations by BGMUT ,
Resequencing Primers from QIAGEN ,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences )
About This Section
Genomic Data Transcription Related Data Allele Frequencies SNP ID Valid Clinical significance Chr 2 pos Sequence # AA Chg Type More # Allele freq Pop Total sample More
HapMap Linkage Disequilibrium report for EVX2 (176942200 - 176948690 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions) Database of Genomic Variants (DGV) variations for EVX2: --
SABiosciences Cancer Mutation PCR Assays
QIAGEN SeqTarget long-range PCR primers in human , mouse , rat for resequencing EVX2
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Disorders
/ Diseasesfor EVX2 gene
(in which this Gene is Involved, According to MalaCards ,
OMIM, UniProtKB ,
the University of Copenhagen DISEASES
database ,
Genatlas , GeneTests ,
GAD ,
HuGE Navigator ,
and/or TGDB .)
About This Section
EVX2 for disorders About GeneDecksing
OMIM gene information: 142991
OMIM disorders : --5 diseases for EVX2 : About MalaCards synpolydactyly sex reversal currarino syndrome syndactyly neuronitis 1 disease from the University of Copenhagen DISEASES database for EVX2 :Syndactyly Export disorders for EVX2 gene to outside databases
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Publicationsfor EVX2 gene (in
PubMed .
Associations of this gene to articles via
1 Entrez Gene ,
2 UniProtKB/Swiss-Prot ,
3 HGNC ,
4 GAD ,
5 PharmGKB ,
6 HMDB ,
7 DrugBank ,
8 UniProtKB/TrEMBL ,
9 Novoseek , and/or
10 fRNAdb )
About This Section PubMed articles for EVX2 gene integrated from 9 sources : (articles sorted by number of sources associating them with EVX2) Utopia : connect your pdf to the dynamic world of online information
EVX2, a human homeobox gene homologous to the even-skipped segmentation gene, is localized at the 5' end of HOX4 locus on chromosome 2. (PubMed id 1675198) 1 , 2 , 3 D'Esposito M....Boncinelli E. (1991) Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PubMed id 15815621) 1 , 2 Hillier L.W....Wilson R.K. (2005) Toward a confocal subcellular atlas of the human proteome. (PubMed id 18029348) 1 Barbe L....Andersson-Svahn H. (2008) A 117-kb microdeletion removing HOXD9-HOXD13 and EVX2 causes synpolydactyly. (PubMed id 11778160) 1 Goodman F.R....Scambler P.J. (2002) NotI flanking sequences: a tool for gene discovery and verification of the human genome. (PubMed id 12136098) 1 Kutsenko A.S....Zabarovsky E.R. (2002) The sequence of the human genome. (PubMed id 11181995) 1 Venter J.C.... Zhu X. (2001) Clustering of two fragile sites and seven homeobox genes in human chromosome region 2q31-->q32.1. (PubMed id 11060466) 1 Limongi M.Z....Rocchi A. (2000) Two cases with interstitial deletions of chromosome 2 and sex reversal in one. (PubMed id 10440834) 1 Slavotinek A....Kingston H. (1999) Localization of the syndactyly type II (synpolydactyly) locus to 2q31 region and identification of tight linkage to HOXD8 intragenic marker. (PubMed id 7581388) 1 Sarfarazi M....Sayli B.S. (1995) Order of six loci at 2q24-q31 and orientation of the HOXD locus. (PubMed id 7896287) 1 Rossi E....Zuffardi O. (1994)
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External Searches for EVX2 gene
(in PubMed ,
OMIM , and NCBI Bookshelf ) About This Section
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Genome Databases showing EVX2 gene
(According to
Entrez Gene ,
HGNC ,
AceView ,
euGenes ,
Ensembl ,
miRBase ,
ECgene ,
Kegg ,
and/or
H-InvDB )
About This Section
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Other Databases showing EVX2 gene
(According to HUGE )
About This Section --
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Specialized Databases showing EVX2 gene (According to PharmGKB ,
ATLAS , HORDE , IMGT , LEIDEN , UniProtKB/Swiss-Prot , and/or UniProtKB/TrEMBL ,Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot )About This Section
Name Description
PharmGKB entry for EVX2 Pharmacogenomics, SNPs, Pathways
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About This Section Patent Information for EVX2 gene: Search GeneIP for patents involving EVX2 GeneCards and IP: Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
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Productsfor EVX2 gene (Antibodies, recombinant proteins, and assays from EMD Millipore , R&D Systems , OriGene , QIAGEN , GenScript , Cell Signaling Technology , SABiosciences , Novus Biologicals , Sino Biological , Enzo Life Sciences , Abcam , ProSpec , Uscn , Thermo Fisher Scientific , Gene Editing from DNA2.0 , Clones from EMD Millipore , OriGene , GenScript , Sino Biological , DNA2.0 , SwitchGear Genomics , Vector BioLabs , Cell lines from GenScript and LifeMap BioReagents , PCR Arrays from SABiosciences , Drugs and/or compounds from EMD Millipore , Tocris Bioscience , and/or
Enzo Life Sciences ), In Situ Hybridization Assays from Advanced Cell Diagnostics About This Section
Browse OriGene Antibodies OriGene shRNA RFP for EVX2 OriGene 29mer shRNA kits in GFP-retroviral vector in human , mouse , rat for EVX2 OriGene genome-wide validated SYBR primer pairs in human , mouse , rat for EVX2 Browse OriGene Protein Over-expression Lysates Browse OriGene Fluorogenic Cell Assay Kits OriGene siRNA for EVX2 Browse 3'-UTR reporter clones for miRNA target validation OriGene untagged cDNA clones in CMV expression vector in human , mouse , rat for EVX2 OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human , mouse , rat for EVX2 Browse OriGene GFP tagged cDNA clones in CMV expression vector Browse OriGene MicroRNA Expression Plasmids Browse OriGene basic RS shRNAs Browse OriGene validated miRNA SYBR primer pairs Browse OriGene full length recombinant human proteins expressed in human HEK293 cells OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling OriGene Custom Antibody Services for EVX2 OriGene Custom Protein Services for EVX2 OriGene Custom Immunoassay Development
QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat EVX2 QIAGEN SeqTarget long-range PCR primers in human , mouse , rat for resequencing EVX2 QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat EVX2 QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human , mouse , rat EVX2 QIAGEN QuantiFast Probe-based Assays in human , mouse , rat EVX2 QIAGEN QuantiTect SYBR Green Assays in human , mouse , rat EVX2
Search Tocris compounds for EVX2
EVX2 Proteins, Antibodies, CLIAs, and ELISAs
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for EVX2
ThermoFisher Antibodies for EVX2
Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat EVX2
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Aliases for EVX2
Databases for EVX2
Disorders / Diseases for EVX2
Domains / Families for EVX2
Drugs / Compounds for EVX2
Expression for EVX2
Function for EVX2
Genomic Views for EVX2
Intellectual Property for EVX2
Orthologs for EVX2
Paralogs for EVX2
Pathways / Interactions for EVX2
Products for EVX2
Proteins for EVX2
Publications for EVX2
Search Box for EVX2
Summaries for EVX2
Transcripts for EVX2
Variants for EVX2
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