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Aliases for EVX2 Gene

Aliases for EVX2 Gene

  • Even-Skipped Homeobox 2 2 3 5
  • EVX-2 3 4
  • Even-Skipped Homeo Box 2 (Homolog Of Drosophila Eve) 3
  • Eve, Even-Skipped Homeobox Homolog 2 (Drosophila) 2
  • Eve, Even-Skipped Homeo Box Homolog 2 3

External Ids for EVX2 Gene

Previous GeneCards Identifiers for EVX2 Gene

  • GC02U990026
  • GC02M175605
  • GC02M176908
  • GC02M177147
  • GC02M176770
  • GC02M176653
  • GC02M168822

Summaries for EVX2 Gene

Entrez Gene Summary for EVX2 Gene

  • This gene is located at the 5' end of the HOXD gene cluster on chromosome 2. The encoded protein is a homeobox transcription factor that is related to the protein encoded by the Drosophila even-skipped (eve) gene, a member of the pair-rule class of segmentation genes. A 117 kb microdeletion at the 5' end of the HOXD gene cluster, which includes this gene and the HOXD9-HOXD13 genes, causes synpolydactyly, a dominantly inherited disease resulting in limb malformation. [provided by RefSeq, Sep 2009]

GeneCards Summary for EVX2 Gene

EVX2 (Even-Skipped Homeobox 2) is a Protein Coding gene. Diseases associated with EVX2 include Synpolydactyly. GO annotations related to this gene include sequence-specific DNA binding. An important paralog of this gene is HOXD3.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for EVX2 Gene

Genomics for EVX2 Gene

Regulatory Elements for EVX2 Gene

Enhancers for EVX2 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around EVX2 on UCSC Golden Path with GeneCards custom track

Genomic Location for EVX2 Gene

176,076,021 bp from pter
176,085,797 bp from pter
9,777 bases
Minus strand

Genomic View for EVX2 Gene

Genes around EVX2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
EVX2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for EVX2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for EVX2 Gene

Proteins for EVX2 Gene

  • Protein details for EVX2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Homeobox even-skipped homolog protein 2
    Protein Accession:

    Protein attributes for EVX2 Gene

    476 amino acids
    Molecular mass:
    47800 Da
    Quaternary structure:
    No Data Available

neXtProt entry for EVX2 Gene

Proteomics data for EVX2 Gene at MOPED

Post-translational modifications for EVX2 Gene

No Post-translational modifications

Other Protein References for EVX2 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for EVX2 Gene

Domains & Families for EVX2 Gene

Gene Families for EVX2 Gene

Suggested Antigen Peptide Sequences for EVX2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 homeobox DNA-binding domain.
  • Belongs to the even-skipped homeobox family.
  • Contains 1 homeobox DNA-binding domain.
  • Belongs to the even-skipped homeobox family.
genes like me logo Genes that share domains with EVX2: view

Function for EVX2 Gene

Molecular function for EVX2 Gene

GENATLAS Biochemistry:
Drosophila even-skipped pair rule gene homolog 2 (murine Evx2),homeo domain encoding gene,expressed in limbs
genes like me logo Genes that share phenotypes with EVX2: view

Animal Models for EVX2 Gene

MGI Knock Outs for EVX2:

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for EVX2 Gene

Localization for EVX2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for EVX2 Gene

Subcellular locations from

Jensen Localization Image for EVX2 Gene COMPARTMENTS Subcellular localization image for EVX2 gene
Compartment Confidence
nucleus 5

No data available for Gene Ontology (GO) - Cellular Components for EVX2 Gene

Pathways & Interactions for EVX2 Gene

SuperPathways for EVX2 Gene

No Data Available

Interacting Proteins for EVX2 Gene

Gene Ontology (GO) - Biological Process for EVX2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006355 regulation of transcription, DNA-templated IEA --
genes like me logo Genes that share ontologies with EVX2: view

No data available for Pathways by source and SIGNOR curated interactions for EVX2 Gene

Drugs & Compounds for EVX2 Gene

No Compound Related Data Available

Transcripts for EVX2 Gene

mRNA/cDNA for EVX2 Gene

(2) REFSEQ mRNAs :
(0) Additional mRNA sequences :
(1) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for EVX2 Gene

Even-skipped homeobox 2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for EVX2 Gene

No ASD Table

Relevant External Links for EVX2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for EVX2 Gene

mRNA expression in normal human tissues for EVX2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for EVX2 Gene

This gene is overexpressed in Testis (x17.4), Cervix - Ectocervix (x10.2), Vagina (x7.7), Colon - Sigmoid (x6.3), and Cervix - Endocervix (x5.7).

Protein differential expression in normal tissues from HIPED for EVX2 Gene

This gene is overexpressed in Heart (68.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for EVX2 Gene

SOURCE GeneReport for Unigene cluster for EVX2 Gene Hs.452341

genes like me logo Genes that share expression patterns with EVX2: view

Protein tissue co-expression partners for EVX2 Gene

Primer Products

No data available for mRNA Expression by UniProt/SwissProt for EVX2 Gene

Orthologs for EVX2 Gene

This gene was present in the common ancestor of animals.

Orthologs for EVX2 Gene

Organism Taxonomy Gene Similarity Type Details
(Canis familiaris)
Mammalia EVX2 35
  • 90.27 (n)
  • 94.5 (a)
EVX2 36
  • 96 (a)
(Mus musculus)
Mammalia Evx2 35
  • 86.16 (n)
  • 91.74 (a)
Evx2 16
Evx2 36
  • 95 (a)
(Pan troglodytes)
Mammalia EVX2 35
  • 99.44 (n)
  • 99.79 (a)
EVX2 36
  • 100 (a)
(Rattus norvegicus)
Mammalia Evx2 35
  • 88.66 (n)
  • 92.51 (a)
(Monodelphis domestica)
Mammalia EVX2 36
  • 91 (a)
(Gallus gallus)
Aves EVX2 35
  • 76.81 (n)
  • 72.58 (a)
EVX2 36
  • 63 (a)
(Anolis carolinensis)
Reptilia EVX2 36
  • 66 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia evx2 35
  • 69.42 (n)
  • 72.81 (a)
(Danio rerio)
Actinopterygii evx2 35
  • 67.62 (n)
  • 72.73 (a)
evx2 36
  • 78 (a)
fruit fly
(Drosophila melanogaster)
Insecta eve 37
  • 71 (a)
eve 36
  • 31 (a)
(Caenorhabditis elegans)
Secernentea vab-7 36
  • 33 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 33 (a)
Species with no ortholog for EVX2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for EVX2 Gene

Gene Tree for EVX2 (if available)
Gene Tree for EVX2 (if available)

Paralogs for EVX2 Gene

(1) SIMAP similar genes for EVX2 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with EVX2: view

Variants for EVX2 Gene

Sequence variations from dbSNP and Humsavar for EVX2 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type
rs847142 -- 176,079,968(-) CCGAA(A/G)GGAAC nc-transcript-variant, downstream-variant-500B, utr-variant-3-prime
rs1868101 -- 176,080,284(-) ggcgg(C/T)ggtgg nc-transcript-variant, reference, synonymous-codon
rs1155721 -- 176,076,753(-) TTCCC(C/G)AGTTC nc-transcript-variant
rs6758117 -- 176,082,509(+) GCTGG(C/T)GCTGC intron-variant
rs9973595 -- 176,077,231(+) ACACT(C/G)TTATC intron-variant, downstream-variant-500B

Structural Variations from Database of Genomic Variants (DGV) for EVX2 Gene

Variant ID Type Subtype PubMed ID
nsv520227 CNV Loss 19592680
dgv676n67 CNV Gain 20364138
nsv875437 CNV Loss 21882294
nsv875438 CNV Loss 21882294
nsv527187 CNV Loss 19592680
nsv517968 CNV Loss 19592680
dgv4368n71 CNV Loss 21882294

Variation tolerance for EVX2 Gene

Residual Variation Intolerance Score: 68.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.10; 22.34% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for EVX2 Gene

Disorders for EVX2 Gene

MalaCards: The human disease database

(1) MalaCards diseases for EVX2 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
  • syndactyly type 2
- elite association - COSMIC cancer census association via MalaCards
Search EVX2 in MalaCards View complete list of genes associated with diseases

Relevant External Links for EVX2

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with EVX2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for EVX2 Gene

Publications for EVX2 Gene

  1. EVX2, a human homeobox gene homologous to the even-skipped segmentation gene, is localized at the 5' end of HOX4 locus on chromosome 2. (PMID: 1675198) D'Esposito M. … Boncinelli E. (Genomics 1991) 2 3 4 67
  2. Genome-wide association study of periodontal pathogen colonization. (PMID: 22699663) Divaris K. … Offenbacher S. (J. Dent. Res. 2012) 3
  3. Toward a confocal subcellular atlas of the human proteome. (PMID: 18029348) Barbe L. … Andersson-Svahn H. (Mol. Cell Proteomics 2008) 3
  4. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PMID: 15815621) Hillier L.W. … Wilson R.K. (Nature 2005) 3
  5. A 117-kb microdeletion removing HOXD9-HOXD13 and EVX2 causes synpolydactyly. (PMID: 11778160) Goodman F.R. … Scambler P.J. (Am. J. Hum. Genet. 2002) 3

Products for EVX2 Gene

Sources for EVX2 Gene