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Aliases for EVX1 Gene

Aliases for EVX1 Gene

  • Even-Skipped Homeobox 1 2 3 5
  • EVX-1 3 4
  • Eve, Even-Skipped Homeobox Homolog 1 (Drosophila) 2
  • Even-Skipped Homeo Box 1 (Homolog Of Drosophila) 3
  • Eve, Even-Skipped Homeo Box Homolog 1 3
  • Eve, Even-Skipped Homeobox Homolog 1 3

External Ids for EVX1 Gene

Previous GeneCards Identifiers for EVX1 Gene

  • GC07P026924
  • GC07P026990
  • GC07P027024
  • GC07P027055
  • GC07P027248
  • GC07P027165
  • GC07P027282
  • GC07P027252
  • GC07P027253

Summaries for EVX1 Gene

Entrez Gene Summary for EVX1 Gene

  • This gene encodes a member of the even-skipped homeobox family characterized by the presence of a homeodomain closely related to the Drosophila even-skipped (eve) segmentation gene of the pair-rule class. The encoded protein may play an important role as a transcriptional repressor during embryogenesis. [provided by RefSeq, Jul 2008]

GeneCards Summary for EVX1 Gene

EVX1 (Even-Skipped Homeobox 1) is a Protein Coding gene. GO annotations related to this gene include transcription factor activity, sequence-specific DNA binding and sequence-specific DNA binding. An important paralog of this gene is HOXD3.

UniProtKB/Swiss-Prot for EVX1 Gene

  • May play a role in the specification of neuronal cell types.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for EVX1 Gene

Genomics for EVX1 Gene

Regulatory Elements for EVX1 Gene

Enhancers for EVX1 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around EVX1 on UCSC Golden Path with GeneCards custom track

Genomic Location for EVX1 Gene

Chromosome:
7
Start:
27,242,545 bp from pter
End:
27,250,493 bp from pter
Size:
7,949 bases
Orientation:
Plus strand

Genomic View for EVX1 Gene

Genes around EVX1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
EVX1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for EVX1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for EVX1 Gene

Proteins for EVX1 Gene

  • Protein details for EVX1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P49640-EVX1_HUMAN
    Recommended name:
    Homeobox even-skipped homolog protein 1
    Protein Accession:
    P49640
    Secondary Accessions:
    • A4D199
    • B4DQJ0

    Protein attributes for EVX1 Gene

    Size:
    407 amino acids
    Molecular mass:
    42440 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for EVX1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for EVX1 Gene

Proteomics data for EVX1 Gene at MOPED

Post-translational modifications for EVX1 Gene

No Post-translational modifications

Other Protein References for EVX1 Gene

No data available for DME Specific Peptides for EVX1 Gene

Domains & Families for EVX1 Gene

Gene Families for EVX1 Gene

Suggested Antigen Peptide Sequences for EVX1 Gene

Graphical View of Domain Structure for InterPro Entry

P49640

UniProtKB/Swiss-Prot:

EVX1_HUMAN :
  • Contains 1 homeobox DNA-binding domain.
  • Belongs to the even-skipped homeobox family.
Domain:
  • Contains 1 homeobox DNA-binding domain.
Family:
  • Belongs to the even-skipped homeobox family.
genes like me logo Genes that share domains with EVX1: view

Function for EVX1 Gene

Molecular function for EVX1 Gene

GENATLAS Biochemistry:
Drosophila even-skipped pair rule gene homolog 1 (murine Evx1),homeo domain encoding gene
UniProtKB/Swiss-Prot Function:
May play a role in the specification of neuronal cell types.

Gene Ontology (GO) - Molecular Function for EVX1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0043565 sequence-specific DNA binding IEA --
genes like me logo Genes that share ontologies with EVX1: view
genes like me logo Genes that share phenotypes with EVX1: view

Animal Models for EVX1 Gene

MGI Knock Outs for EVX1:

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for EVX1 Gene

Localization for EVX1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for EVX1 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for EVX1 Gene COMPARTMENTS Subcellular localization image for EVX1 gene
Compartment Confidence
nucleus 5

Gene Ontology (GO) - Cellular Components for EVX1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0031965 nuclear membrane IDA --
genes like me logo Genes that share ontologies with EVX1: view

Pathways & Interactions for EVX1 Gene

SuperPathways for EVX1 Gene

No Data Available

Interacting Proteins for EVX1 Gene

Gene Ontology (GO) - Biological Process for EVX1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0045944 positive regulation of transcription from RNA polymerase II promoter IEA --
genes like me logo Genes that share ontologies with EVX1: view

No data available for Pathways by source and SIGNOR curated interactions for EVX1 Gene

Drugs & Compounds for EVX1 Gene

No Compound Related Data Available

Transcripts for EVX1 Gene

mRNA/cDNA for EVX1 Gene

Unigene Clusters for EVX1 Gene

Even-skipped homeobox 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for EVX1 Gene

No ASD Table

Relevant External Links for EVX1 Gene

GeneLoc Exon Structure for
EVX1
ECgene alternative splicing isoforms for
EVX1

Expression for EVX1 Gene

mRNA expression in normal human tissues for EVX1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for EVX1 Gene

This gene is overexpressed in Bladder (x15.0), Vagina (x10.2), Prostate (x9.6), Cervix - Ectocervix (x4.7), and Testis (x4.6).

SOURCE GeneReport for Unigene cluster for EVX1 Gene Hs.369879

genes like me logo Genes that share expression patterns with EVX1: view

Primer Products

No data available for Protein differential expression in normal tissues , Protein expression , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for EVX1 Gene

Orthologs for EVX1 Gene

This gene was present in the common ancestor of animals.

Orthologs for EVX1 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia EVX1 35
  • 91.5 (n)
  • 94.8 (a)
EVX1 36
  • 95 (a)
OneToOne
dog
(Canis familiaris)
Mammalia EVX1 35
  • 91.34 (n)
  • 93.81 (a)
EVX1 36
  • 91 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Evx1 35
  • 90.01 (n)
  • 94.35 (a)
Evx1 16
Evx1 36
  • 92 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia EVX1 35
  • 99.26 (n)
  • 98.77 (a)
EVX1 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Evx1 35
  • 89.68 (n)
  • 94.1 (a)
oppossum
(Monodelphis domestica)
Mammalia EVX1 36
  • 77 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia EVX1 36
  • 77 (a)
OneToOne
chicken
(Gallus gallus)
Aves LOC100859345 35
  • 76.95 (n)
  • 75.62 (a)
EVX1 36
  • 76 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia EVX1 36
  • 69 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100496893 35
  • 70.18 (n)
  • 73.26 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.277 35
zebrafish
(Danio rerio)
Actinopterygii evx1 35
  • 71.39 (n)
  • 80.09 (a)
evx1 36
  • 60 (a)
OneToMany
evx1 36
  • 73 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta eve 37
  • 60 (a)
eve 36
  • 31 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea vab-7 36
  • 35 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 20 (a)
OneToMany
Species with no ortholog for EVX1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for EVX1 Gene

ENSEMBL:
Gene Tree for EVX1 (if available)
TreeFam:
Gene Tree for EVX1 (if available)

Paralogs for EVX1 Gene

(6) SIMAP similar genes for EVX1 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with EVX1: view

Variants for EVX1 Gene

Sequence variations from dbSNP and Humsavar for EVX1 Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type
rs886338 -- 27,240,836(+) CTCCC(C/G)TCACT upstream-variant-2KB
rs34762576 -- 27,240,801(+) GCTCT(-/C)CCAAG upstream-variant-2KB
rs189249572 -- 27,240,834(+) GACTC(C/T)CCTCA upstream-variant-2KB
rs59007191 -- 27,240,660(+) CCCTA(A/T)AGAGA upstream-variant-2KB
rs186416383 -- 27,240,817(+) AAAAG(G/T)TTCTA upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for EVX1 Gene

Variant ID Type Subtype PubMed ID
nsv7393 OTHER Inversion 18451855
nsv887856 CNV Loss 21882294
dgv1094n67 CNV Gain 20364138
dgv7234n71 CNV Loss 21882294
dgv7237n71 CNV Loss 21882294
nsv519583 CNV Gain 19592680

Variation tolerance for EVX1 Gene

Residual Variation Intolerance Score: 18.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.23; 40.15% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for EVX1 Gene

Disorders for EVX1 Gene

Relevant External Links for EVX1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
EVX1

No disorders were found for EVX1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for EVX1 Gene

Publications for EVX1 Gene

  1. Isolation and mapping of EVX1, a human homeobox gene homologous to even-skipped, localized at the 5' end of HOX1 locus on chromosome 7. (PMID: 1684419) Faiella A. … Gulisano M. (Nucleic Acids Res. 1991) 2 3 4 23 67
  2. Genome-wide association analysis of blood-pressure traits in African-ancestry individuals reveals common associated genes in African and non-African populations. (PMID: 23972371) Franceschini N. … Zhu X. (Am. J. Hum. Genet. 2013) 3
  3. A cohesin-RAD21 interactome. (PMID: 22145905) Panigrahi A.K. … Pati D. (Biochem. J. 2012) 3
  4. EVEN-SKIPPED HOMEOBOX 1 controls human ES cell differentiation by directly repressing GOOSECOID expression. (PMID: 22178155) Kalisz M. … Serup P. (Dev. Biol. 2012) 3
  5. Association of genome-wide variation with the risk of incident heart failure in adults of European and African ancestry: a prospective meta-analysis from the cohorts for heart and aging research in genomic epidemiology (CHARGE) consortium. (PMID: 20445134) Smith N.L. … Vasan R.S. (Circ Cardiovasc Genet 2010) 3

Products for EVX1 Gene

Sources for EVX1 Gene

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