EVX1 Gene
protein-coding GIFtS : 48
GCID: GC07 P027282
even-skipped homeobox 1 (Previous names: eve, even-skipped homeobox homolog 1 (Drosophila) )
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Aliasesfor EVX1 gene
(According to
1 HGNC ,
2 Entrez Gene ,
3 UniProtKB/Swiss-Prot ,
4 UniProtKB/TrEMBL , 5 OMIM , 6 GeneLoc ,
7 Ensembl ,
8 DME ,
9 miRBase ,
and/or 10 fRNAdb )About This Section Aliases Even-Skipped Homeobox 1 1 2 Eve, Even-Skipped Homeobox Homolog 12 EVX-12 3 Even-Skipped Homeo Box 1 (Homolog Of Drosophila)2 Eve, Even-Skipped Homeobox Homolog 1 (Drosophila)1 Homeobox Even-Skipped Homolog Protein 12 Eve, Even-Skipped Homeo Box Homolog 12
Export aliases for EVX1 gene to outside databases Previous GC identifers: GC07P026924 GC07P026990 GC07P027024 GC07P027055 GC07P027248 GC07P027165
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Summariesfor EVX1 gene (According to Entrez Gene ,
Tocris Bioscience ,
Wikipedia's
Gene Wiki ,
PharmGKB ,
UniProtKB/Swiss-Prot ,
and/or
UniProtKB/TrEMBL )
About This Section Entrez Gene summary for EVX1 : This gene encodes a member of the even-skipped homeobox family characterized by the presence of a homeodomain closely related to the Drosophila even-skipped (eve) segmentation gene of the pair-rule class. The encoded protein may play an important role as a transcriptional repressor during embryogenesis. (provided by RefSeq, Jul 2008) UniProtKB/Swiss-Prot: EVX1_HUMAN, P49640 Function : May play a role in the specification of neuronal cell types
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Genomic Viewsfor EVX1 gene
(According to
GeneLoc and/or
HGNC , and/or
Entrez Gene (NCBI build 37) ,
and/or miRBase ,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69) ,
Regulatory elements and Epigenetics data according to
QIAGEN ,
SABiosciences , and/or
SwitchGear Genomics )About This Section RefSeq DNA sequence: NC_000007.13 NC_018918.1 NT_007819.17 NT_079592.2 Regulatory elements: SABiosciences Regulatory transcription factor binding sites in the EVX1 gene promoter: Sox5 Lmo2 Nkx2-5 GATA-1 NF-AT NF-AT4 NF-AT2 NF-AT3 IRF-7A NF-AT1 Other transcription factors Search SABiosciences Chromatin IP Primers for EVX1 Epigenetics: QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human , mouse , rat EVX1
Genomic Location: Genomic View : UCSC Golden Path with GeneCards custom track Entrez Gene cytogenetic band: 7p15.2 Ensembl cytogenetic band: 7p15.2 HGNC cytogenetic band: 7p15.2 EVX1 Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different) GeneLoc information about chromosome 7 GeneLoc Exon Structure
GeneLoc location for GC07P027282: view genomic region
(about GC identifiers )
Start:
27,282,164 bp from pter
End:
27,287,047 bp from pter
Size:
4,884 bases
Orientation:
plus strand
1 alternative location : Chr 7+,CRA_TCAG 27,333,351-27,337,379
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Proteinsfor EVX1 gene
(According to
1 UniProtKB ,
HORDE ,
neXtProt ,
Ensembl ,
and/or Reactome ,
Modification sites according to 2 PhosphoSitePlus ,
Specific Peptides from DME ,
Protein expression images according to data from SPIRE MOPED and PaxDb ,
RefSeq according to NCBI ,
PDB rendering according to OCA and/or Proteopedia ,
Recombinant Proteins
from
EMD Millipore ,
R&D Systems ,
GenScript ,
Enzo Life Sciences ,
OriGene ,
Novus Biologicals ,
Sino Biological ,
ProSpec , and/or
Uscn ,
Biochemical Assays by
EMD Millipore ,
R&D Systems ,
OriGene ,
GenScript ,
Cell Signaling Technology ,
Enzo Life Sciences , and/or
Uscn ,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene ,
Antibodies by
EMD Millipore ,
R&D Systems ,
GenScript ,
Cell Signaling Technology ,
OriGene ,
Novus Biologicals ,
Thermo Fisher Scientific ,
Abcam , and/or
Uscn )
About This Section UniProtKB/Swiss-Prot: EVX1_HUMAN, P49640 (See
protein sequence )Recommended Name: Homeobox even-skipped homolog protein 1 Size : 407 amino acids; 42440 Da
Subcellular location : Nucleus
Secondary accessions : A4D199Explore the universe of human proteins at neXtProt for EVX1: NX_P49640 EVX1 Protein expression data from MOPED and PaxDb : About this image
REFSEQ proteins: NP_001980.1 ENSEMBL proteins: ENSP00000419266 ENSP00000222761 ENSP00000463759 ENSP00000446458 Human Recombinant Protein Products: Gene Ontology (GO): 1 cellular component term (GO ID links to tree view) : About this table
GO ID Qualified GO term Evidence PubMed IDs GO:0005634 nucleus
IEA --
EVX1 for ontologies About GeneDecksing EVX1 Antibody Products: Assay Products for EVX1:
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Protein
Domains / Familiesfor EVX1 gene (According to InterPro , ProtoNet ,
UniProtKB , and/or BLOCKS ,
Sets of similar genes according to GeneDecks )
About This Section
EVX1 for domains About GeneDecksing 4 InterPro domains/families :
Graphical View of Domain Structure for InterPro Entry P49640 ProtoNet protein and cluster: P49640
1 Blocks protein family : IPB000047 Lambda and other repressor helix-turn-helix signature UniProtKB/Swiss-Prot: EVX1_HUMAN, P49640 Similarity : Belongs to the even-skipped homeobox familySimilarity : Contains 1 homeobox DNA-binding domain
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Functionfor EVX1 gene
(According to 1 UniProtKB ,
Genatlas ,
LifeMap Discovery™ ,
IUBMB , and/or
2 DME ,
Human phenotypes from GenomeRNAi ,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences ,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene ,
RNAi from
EMD Millipore ,
siRNAs from
OriGene ,
QIAGEN ,
microRNA from QIAGEN ,
Gene Editing from DNA2.0 ,
Clones from EMD Millipore ,
OriGene ,
SwitchGear Genomics ,
GenScript ,
Sino Biological ,
DNA2.0 ,
and Vector BioLabs ,
Cell Lines from GenScript ,
LifeMap BioReagents ,
In Situ Hybridization Assays from Advanced Cell Diagnostics ,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene .)
About This Section Function Summary: UniProtKB/Swiss-Prot: EVX1_HUMAN, P49640 Function : May play a role in the specification of neuronal cell types
Genatlas biochemistry entry for EVX1 : Drosophila even-skipped pair rule gene homolog 1 (murine Evx1),homeo domain encoding gene Clone Products: Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human , mouse , rat for EVX1 (see all 2 ) OriGene untagged cDNA clones in CMV expression vector in human , mouse , rat for EVX1OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling GenScript: all cDNA clones in your preferred vector: EVX1 (NM_001989 ) Browse Sino Biological Human cDNA Clones DNA2.0 Custom Codon Optimized Gene
Synthesis Service for EVX1 Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat EVX1
In Situ Assay Products: Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for EVX1
Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view) : About this table
GO ID Qualified GO term Evidence PubMed IDs GO:0003700 sequence-specific DNA binding transcription factor activity
IEA -- GO:0043565 sequence-specific DNA binding
IEA --
EVX1 for ontologies About GeneDecksing Animal Models: Mouse knock-out Evx1 tm1Mrc for EVX1 4 MGI mutant phenotypes (inferred from 3 alleles ) (MGI details for Evx1) :
EVX1 for phenotypes About GeneDecksing
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Pathways & Interactionsfor EVX1 gene
(Pathways according to
EMD Millipore ,
R&D Systems ,
Cell Signaling Technology ,
KEGG ,
PharmGKB ,
BioSystems ,
Reactome ,
Tocris Bioscience ,
GeneGo (Thomson Reuters) ,
QIAGEN ,
and/or UniProtKB ,
Sets of similar genes according to GeneDecks ,
Interaction Networks according to
SABiosciences ,
and/or STRING ,
Interactions according to 1 UniProtKB ,
2 MINT ,
3 I2D , and/or
4 STRING ,
with links to IntAct and
Ensembl ,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene) .
About This Section Interactions: Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for EVX1 Gene Ontology (GO): 4 biological process terms (GO ID links to tree view) : About this table
GO ID Qualified GO term Evidence PubMed IDs GO:0006355 regulation of transcription, DNA-dependent
-- -- GO:0009792 embryo development ending in birth or egg hatching
IEA -- GO:0021913 regulation of transcription from RNA polymerase II promoter involved in ventral spinal cord interneuron specification
IEA -- GO:0045944 positive regulation of transcription from RNA polymerase II promoter
IEA --
EVX1 for ontologies About GeneDecksing
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Drugs & Compoundsfor EVX1 gene (Chemical Compounds according to UniProtKB , Enzo Life Sciences ,
EMD Millipore , Tocris Bioscience
HMDB ,
BitterDB , and/or
Novoseek , and Drugs according to
DrugBank ,
Enzo Life Sciences , and/or
PharmGKB , with drugs/clinical trials/news
search links to CenterWatch )
About This Section Browse Tocris compounds for EVX1 Search CenterWatch for drugs/clinical trials and news about EVX1
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Transcriptsfor EVX1 gene (Secondary structures according to
fRNAdb ,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank , RefSeq according to Entrez Gene ,
DOTS (version 10), and/or
AceView ,
transcript ids from Ensembl
with links to UCSC ,
exon structure from GeneLoc ,
alternative splicing isoforms according to ASD and/or
ECgene ,
RNAi Products from
EMD Millipore ,
siRNAs from
OriGene ,
QIAGEN ,
shRNA from
OriGene ,
microRNA from QIAGEN ,
Tagged/untagged cDNA clones from
OriGene ,
SwitchGear Genomics ,
GenScript ,
DNA2.0 ,
Vector BioLabs ,
Primers from
OriGene ,
SABiosciences , and/or
QIAGEN
)About This Section REFSEQ mRNAs for EVX1 gene: NM_001989.3 Unigene Cluster for EVX1:
Even-skipped homeobox 1 Hs.369879 [show with all ESTs ] Unigene Representative Sequence: NM_001989 4 Ensembl transcripts including schematic representations, and UCSC links where relevant : ENST00000496902 (uc003szd.1 uc011jzn.1 uc010kuy.1 ) ENST00000222761 ENST00000580535 ENST00000535619 Clone Products: OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human , mouse , rat for EVX1 (see all 2 ) OriGene untagged cDNA clones in CMV expression vector in human , mouse , rat for EVX1OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling GenScript: all cDNA clones in your preferred vector: EVX1 (NM_001989 ) DNA2.0 Custom Codon Optimized Gene
Synthesis Service for EVX1 Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat EVX1
Additional cDNA sequence: AK298822.1 AK299188.1 AK314155.1 X60655.1
3 DOTS entries : DT.99998704 DT.92414599
DT.40130881 14 AceView cDNA sequences :
NM_001989 AI733008 AI215159 AI346148 AI273407 AI820879 AI280183 AA922834 X60655 AI346582 AI792726 BX103771 AI368067 AI268901 GeneLoc Exon Structure
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Expression for EVX1 gene
(RNA expression data according to
H-InvDB ,
NONCODE ,
miRBase , and
RNAdb ,
Expression images according to data from
BioGPS ,
Illumina Human BodyMap , and
CGAP
SAGE ,
Sets of similar genes according to GeneDecks ,
in vivo and in vitro expression data from LifeMap Discovery™ ,
plus additional links to
Genevestigator , and/or
SOURCE , and/or
BioGPS , and/or
UniProtKB ,
PCR Arrays from
SABiosciences ,
Primers from
OriGene ,
SABiosciences , and/or
QIAGEN ,
In Situ Hybridization Assays from Advanced Cell Diagnostics )
About This Section EVX1 expression in normal human tissues (normalized intensities) See probesets specificity/sensitivity at GeneAnnot About this image BioGPS CGAP TAG: ACGCCCGTGG
About this image EVX1 expression in embryonic tissues and stem cells Expression by the Database of Embryonic development, Stem cell research, and
Regenerative medicine About this table See EVX1 Protein Expression from SPIRE MOPED and PaxDB Genevestigator expression for EVX1 SOURCE GeneReport for Unigene cluster: Hs.369879 SABiosciences Custom PCR Arrays for EVX1 Primer Products: OriGene genome-wide validated SYBR primer pairs in human , mouse , rat for EVX1Browse OriGene validated miRNA SYBR primer pairs SABiosciences RT2 qPCR Primer Assay in human , mouse , rat EVX1 QIAGEN QuantiTect SYBR Green Assays in human , mouse , rat EVX1 QIAGEN QuantiFast Probe-based Assays in human , mouse , rat EVX1 In Situ Assay Products: Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for EVX1
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Orthologsfor EVX1 gene
(Orthologs according to
1,2 HomoloGene (2 older version, for species not in 1 newer version),
3 euGenes ,
4 SGD
,
5 MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase ,
and/or
6 Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam )
About This Section
This gene was present in the common ancestor of animals.
Orthologs for EVX1 gene from 6/19 species (see all 19 ) About this table
Organism
Taxonomic classification
Gene
Description
Human Similarity
Orthology Type
Details
chicken (Gallus gallus)
Aves
LOC1008593451
homeobox even-skipped homolog protein 1-like
77.69(n) 77.11(a)
 
100859345 XM_003640719.1 XP_003640767.1
lizard (Anolis carolinensis)
Reptilia
EVX16
--
69(a)
1 ↔ 1
GL343275.1(1243115-1256504)
African clawed frog (Xenopus laevis)
Amphibia
Xl.2772
X.laevis mRNA for Xhox3 homeobox protein, complete more
78.55(n)
 
D10455.1
zebrafish (Danio rerio)
Actinopterygii
evx12
even-skipped homeobox 1
76.85(n)
 
30499 AF305889.1
fruit fly (Drosophila melanogaster)
Insecta
eve3
blastoderm segmentation specific RNA polymerase more
60(a)
 
46C10 --
worm (Caenorhabditis elegans)
Secernentea
vab-76
Homeobox protein vab-7
32(a)
1 → many
III(10920237-10925942)
ENSEMBL Gene Tree for EVX1 (if available)TreeFam Gene Tree for EVX1 (if available)
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Paralogsfor EVX1 gene (Paralogs according to
1 HomoloGene , 2 Ensembl , and 3 SIMAP , Pseudogenes according to 4 Pseudogene.org Build 68)About This Section Paralogs for EVX1 gene NKX1-2 2 MEOX1 2 EVX2 2 GBX1 2 NKX1-1 2 GBX2 2 MNX1 2 MEOX2 2 7 SIMAP similar genes for EVX1 using alignment to 4 protein entries: EVX1_HUMAN (see all proteins ):HOXB1 HOXC13 MEOX1 HOX B6 NKX2-5 EVX2 HOXA4
EVX1 for paralogs About GeneDecksing
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Genomic Variantsfor EVX1 gene (SNPs/Variants according to the
1 NCBI SNP Database ,
2 Ensembl ,
3 PupaSUITE ,
UniProtKB , and
DNA2.0 ,
Linkage Disequilibrium by HapMap ,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants , Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB) , Blood group antigen gene mutations by BGMUT ,
Resequencing Primers from QIAGEN ,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences )
About This Section
Genomic Data Transcription Related Data Allele Frequencies SNP ID Valid Clinical significance Chr 7 pos Sequence # AA Chg Type More # Allele freq Pop Total sample More
HapMap Linkage Disequilibrium report for EVX1 (27282164 - 27287047 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions) Database of Genomic Variants (DGV) variations for EVX1: --
SABiosciences Cancer Mutation PCR Assays
QIAGEN SeqTarget long-range PCR primers in human , mouse , rat for resequencing EVX1
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Disorders
/ Diseasesfor EVX1 gene
(in which this Gene is Involved, According to MalaCards ,
OMIM, UniProtKB ,
the University of Copenhagen DISEASES
database ,
Genatlas , GeneTests ,
GAD ,
HuGE Navigator ,
and/or TGDB .)
About This Section
EVX1 for disorders About GeneDecksing
OMIM gene information: 142996
OMIM disorders : --2 diseases for EVX1 : About MalaCards currarino syndrome neuronitis Export disorders for EVX1 gene to outside databases
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Publicationsfor EVX1 gene (in
PubMed .
Associations of this gene to articles via
1 Entrez Gene ,
2 UniProtKB/Swiss-Prot ,
3 HGNC ,
4 GAD ,
5 PharmGKB ,
6 HMDB ,
7 DrugBank ,
8 UniProtKB/TrEMBL ,
9 Novoseek , and/or
10 fRNAdb )
About This Section PubMed articles for EVX1 gene integrated from 9 sources : (articles sorted by number of sources associating them with EVX1) Utopia : connect your pdf to the dynamic world of online information
Isolation and mapping of EVX1, a human homeobox gene homologous to even-skipped, localized at the 5' end of HOX1 locus on chromosome 7. (PubMed id 1684419) 1 , 2 , 3, 9 Faiella A.... Gulisano M. (1991) Human chromosome 7: DNA sequence and biology. (PubMed id 12690205) 1 , 2 Scherer S.W.... Tsui L.-C. (2003) The DNA sequence of human chromosome 7. (PubMed id 12853948) 1 , 2 Hillier L.W.... Wilson R.K. (2003) Transcriptional repression by the human homeobox protein EVX1 in transfected mammalian cells. (PubMed id 7499236) 1 , 2 Briata P.... Corte G. (1995) A cohesin-RAD21 interactome. (PubMed id 22145905) 1 Panigrahi A.K....Pati D. (2012) EVEN-SKIPPED HOMEOBOX 1 controls human ES cell differe ntiation by directly repressing GOOSECOID expression. (PubMed id 22178155) 1 Kalisz M....Serup P. (2012) Association of genome-wide variation with the risk of incident heart failure in adults of European and African ancestry: a prospecti ve meta-analysis from the cohorts for heart and aging research in genomic epide miology (CHARGE) consortium. (PubMed id 20445134) 1 Smith N.L....Vasan R.S. (2010) Toward a complete human genome sequence. (PubMed id 9847074) 1 Wilson R. (1998) Function of FGF-4 in limb development. (PubMed id 7999365) 9 Niswander L....Martin G. (1994)
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External Searches for EVX1 gene
(in PubMed ,
OMIM , and NCBI Bookshelf ) About This Section
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Genome Databases showing EVX1 gene
(According to
Entrez Gene ,
HGNC ,
AceView ,
euGenes ,
Ensembl ,
miRBase ,
ECgene ,
Kegg ,
and/or
H-InvDB )
About This Section
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Other Databases showing EVX1 gene
(According to HUGE )
About This Section --
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Specialized Databases showing EVX1 gene (According to PharmGKB ,
ATLAS , HORDE , IMGT , LEIDEN , UniProtKB/Swiss-Prot , and/or UniProtKB/TrEMBL ,Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot )About This Section
Name Description
PharmGKB entry for EVX1 Pharmacogenomics, SNPs, Pathways
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About This Section Patent Information for EVX1 gene: Search GeneIP for patents involving EVX1 GeneCards and IP: Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
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Productsfor EVX1 gene (Antibodies, recombinant proteins, and assays from EMD Millipore , R&D Systems , OriGene , QIAGEN , GenScript , Cell Signaling Technology , SABiosciences , Novus Biologicals , Sino Biological , Enzo Life Sciences , Abcam , ProSpec , Uscn , Thermo Fisher Scientific , Gene Editing from DNA2.0 , Clones from EMD Millipore , OriGene , GenScript , Sino Biological , DNA2.0 , SwitchGear Genomics , Vector BioLabs , Cell lines from GenScript and LifeMap BioReagents , PCR Arrays from SABiosciences , Drugs and/or compounds from EMD Millipore , Tocris Bioscience , and/or
Enzo Life Sciences ), In Situ Hybridization Assays from Advanced Cell Diagnostics About This Section
Browse OriGene Antibodies OriGene shRNA RFP for EVX1 OriGene 29mer shRNA kits in GFP-retroviral vector in human , mouse , rat for EVX1 OriGene genome-wide validated SYBR primer pairs in human , mouse , rat for EVX1 OriGene Protein Over-expression Lysate for EVX1 Browse OriGene Fluorogenic Cell Assay Kits OriGene siRNA for EVX1 OriGene 3'-UTR Clone for EVX1 OriGene untagged cDNA clones in CMV expression vector in human , mouse , rat for EVX1 OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human , mouse , rat for EVX1 Browse OriGene GFP tagged cDNA clones in CMV expression vector Browse OriGene MicroRNA Expression Plasmids Browse OriGene basic RS shRNAs Browse OriGene validated miRNA SYBR primer pairs Browse OriGene full length recombinant human proteins expressed in human HEK293 cells OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling OriGene Custom Antibody Services for EVX1 OriGene Custom Protein Services for EVX1 OriGene Custom Immunoassay Development
QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat EVX1 QIAGEN SeqTarget long-range PCR primers in human , mouse , rat for resequencing EVX1 QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human , mouse , rat EVX1 QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human , mouse , rat EVX1 QIAGEN QuantiFast Probe-based Assays in human , mouse , rat EVX1 QIAGEN QuantiTect SYBR Green Assays in human , mouse , rat EVX1
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EVX1 Proteins, Antibodies, CLIAs, and ELISAs
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for EVX1
ThermoFisher Antibodies for EVX1
Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat EVX1
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Aliases for EVX1
Databases for EVX1
Disorders / Diseases for EVX1
Domains / Families for EVX1
Drugs / Compounds for EVX1
Expression for EVX1
Function for EVX1
Genomic Views for EVX1
Intellectual Property for EVX1
Orthologs for EVX1
Paralogs for EVX1
Pathways / Interactions for EVX1
Products for EVX1
Proteins for EVX1
Publications for EVX1
Search Box for EVX1
Summaries for EVX1
Transcripts for EVX1
Variants for EVX1
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