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Aliases for EVX1 Gene

Aliases for EVX1 Gene

  • Even-Skipped Homeobox 1 2 3
  • EVX-1 3 4
  • Eve, Even-Skipped Homeobox Homolog 1 (Drosophila) 2
  • Even-Skipped Homeo Box 1 (Homolog Of Drosophila) 3
  • Homeobox Even-Skipped Homolog Protein 1 3
  • Eve, Even-Skipped Homeo Box Homolog 1 3
  • Eve, Even-Skipped Homeobox Homolog 1 3

External Ids for EVX1 Gene

Summaries for EVX1 Gene

Entrez Gene Summary for EVX1 Gene

  • This gene encodes a member of the even-skipped homeobox family characterized by the presence of a homeodomain closely related to the Drosophila even-skipped (eve) segmentation gene of the pair-rule class. The encoded protein may play an important role as a transcriptional repressor during embryogenesis. [provided by RefSeq, Jul 2008]

GeneCards Summary for EVX1 Gene

EVX1 (Even-Skipped Homeobox 1) is a Protein Coding gene. GO annotations related to this gene include sequence-specific DNA binding transcription factor activity and sequence-specific DNA binding. An important paralog of this gene is HOXB1.

UniProtKB/Swiss-Prot for EVX1 Gene

  • May play a role in the specification of neuronal cell types

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for EVX1 Gene

Genomics for EVX1 Gene

Genomic Location for EVX1 Gene

27,242,545 bp from pter
27,247,819 bp from pter
5,275 bases
Plus strand

Genomic View for EVX1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for EVX1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for EVX1 Gene

Regulatory Elements for EVX1 Gene

Proteins for EVX1 Gene

  • Protein details for EVX1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Homeobox even-skipped homolog protein 1
    Protein Accession:
    Secondary Accessions:
    • A4D199
    • B4DQJ0

    Protein attributes for EVX1 Gene

    407 amino acids
    Molecular mass:
    42440 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for EVX1 Gene


neXtProt entry for EVX1 Gene

Proteomics data for EVX1 Gene at MOPED

Post-translational modifications for EVX1 Gene

No Post-translational modifications

Other Protein References for EVX1 Gene

No data available for DME Specific Peptides for EVX1 Gene

Domains for EVX1 Gene

Gene Families for EVX1 Gene

  • HOXL :Homeoboxes / ANTP class : HOXL subclass


  • Contains 1 homeobox DNA-binding domain.:
    • P49640
  • Belongs to the even-skipped homeobox family.:
    • P49640
genes like me logo Genes that share domains with EVX1: view

Function for EVX1 Gene

Molecular function for EVX1 Gene

GENATLAS Biochemistry: Drosophila even-skipped pair rule gene homolog 1 (murine Evx1),homeo domain encoding gene
UniProtKB/Swiss-Prot Function: May play a role in the specification of neuronal cell types

Gene Ontology (GO) - Molecular Function for EVX1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding --
GO:0003700 sequence-specific DNA binding transcription factor activity TAS 1684419
GO:0043565 sequence-specific DNA binding IEA --
genes like me logo Genes that share ontologies with EVX1: view
genes like me logo Genes that share phenotypes with EVX1: view

Animal Models for EVX1 Gene

MGI Knock Outs for EVX1:

No data available for Enzyme Numbers (IUBMB) , miRNA , Transcription Factor Targeting and HOMER Transcription for EVX1 Gene

Localization for EVX1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for EVX1 Gene

Subcellular locations from

Jensen Localization Image for EVX1 Gene COMPARTMENTS Subcellular localization image for EVX1 gene
Compartment Confidence
nucleus 5

Gene Ontology (GO) - Cellular Components for EVX1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with EVX1: view

Pathways for EVX1 Gene

SuperPathways for EVX1 Gene

No Data Available

Interacting Proteins for EVX1 Gene

Gene Ontology (GO) - Biological Process for EVX1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0009792 embryo development ending in birth or egg hatching IEA --
GO:0021913 regulation of transcription from RNA polymerase II promoter involved in ventral spinal cord interneuron specification IEA --
GO:0045944 positive regulation of transcription from RNA polymerase II promoter IEA --
genes like me logo Genes that share ontologies with EVX1: view

No data available for Pathways by source for EVX1 Gene

Transcripts for EVX1 Gene

mRNA/cDNA for EVX1 Gene

(4) REFSEQ mRNAs :
(4) Additional mRNA sequences :
(14) Selected AceView cDNA sequences:
(3) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for EVX1 Gene

Even-skipped homeobox 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for EVX1 Gene

No ASD Table

Relevant External Links for EVX1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for EVX1 Gene

mRNA expression in normal human tissues for EVX1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for EVX1 Gene

This gene is overexpressed in Bladder (15.0), Vagina (10.2), Prostate (9.6), Cervix - Ectocervix (4.7), and Testis (4.6).

SOURCE GeneReport for Unigene cluster for EVX1 Gene Hs.369879

genes like me logo Genes that share expressions with EVX1: view

Orthologs for EVX1 Gene

This gene was present in the common ancestor of animals.

Orthologs for EVX1 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia EVX1 36
  • 99.26 (n)
  • 98.77 (a)
EVX1 37
  • 99 (a)
(Bos Taurus)
Mammalia EVX1 36
  • 91.5 (n)
  • 94.8 (a)
EVX1 37
  • 95 (a)
(Canis familiaris)
Mammalia EVX1 36
  • 91.34 (n)
  • 93.81 (a)
EVX1 37
  • 91 (a)
(Mus musculus)
Mammalia Evx1 36
  • 90.01 (n)
  • 94.35 (a)
Evx1 16
Evx1 37
  • 92 (a)
(Monodelphis domestica)
Mammalia EVX1 37
  • 77 (a)
(Ornithorhynchus anatinus)
Mammalia EVX1 37
  • 77 (a)
(Rattus norvegicus)
Mammalia Evx1 36
  • 89.68 (n)
  • 94.1 (a)
(Gallus gallus)
Aves EVX1 37
  • 76 (a)
LOC100859345 36
  • 76.95 (n)
  • 75.62 (a)
(Anolis carolinensis)
Reptilia EVX1 37
  • 69 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.277 36
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100496893 36
  • 70.18 (n)
  • 73.26 (a)
(Danio rerio)
Actinopterygii evx1 36
  • 71.39 (n)
  • 80.09 (a)
evx1 37
  • 60 (a)
evx1 37
  • 73 (a)
fruit fly
(Drosophila melanogaster)
Insecta eve 37
  • 31 (a)
eve 38
  • 60 (a)
(Caenorhabditis elegans)
Secernentea vab-7 37
  • 35 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 37
  • 20 (a)
Species with no ortholog for EVX1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for EVX1 Gene

Gene Tree for EVX1 (if available)
Gene Tree for EVX1 (if available)

Paralogs for EVX1 Gene

Selected SIMAP similar genes for EVX1 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with EVX1: view

Variants for EVX1 Gene

Sequence variations from dbSNP and Humsavar for EVX1 Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type MAF
rs886338 -- 27,240,836(+) CTCCC(C/G)TCACT upstream-variant-2KB
rs34762576 -- 27,240,801(+) GCTCT(-/C)CCAAG upstream-variant-2KB
rs59007191 -- 27,240,660(+) CCCTA(A/T)AGAGA upstream-variant-2KB
rs186416383 -- 27,240,817(+) AAAAG(G/T)TTCTA upstream-variant-2KB
rs189249572 -- 27,240,834(+) GACTC(C/T)CCTCA upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for EVX1 Gene

Variant ID Type Subtype PubMed ID
nsv7393 OTHER Inversion 18451855
nsv887856 CNV Loss 21882294
dgv1094n67 CNV Gain 20364138
dgv7234n71 CNV Loss 21882294
dgv7237n71 CNV Loss 21882294
nsv519583 CNV Gain 19592680

Relevant External Links for EVX1 Gene

HapMap Linkage Disequilibrium report

Disorders for EVX1 Gene

No disorders were found for EVX1 Gene.

No data available for UniProtKB/Swiss-Prot for EVX1 Gene

Publications for EVX1 Gene

  1. Isolation and mapping of EVX1, a human homeobox gene homologous to even-skipped, localized at the 5' end of HOX1 locus on chromosome 7. (PMID: 1684419) Faiella A. … Gulisano M. (Nucleic Acids Res. 1991) 2 3 4 23
  2. Transcriptional repression by the human homeobox protein EVX1 in transfected mammalian cells. (PMID: 7499236) Briata P. … Corte G. (J. Biol. Chem. 1995) 3 4
  3. Human chromosome 7: DNA sequence and biology. (PMID: 12690205) Scherer S.W. … Tsui L.-C. (Science 2003) 3 4
  4. The DNA sequence of human chromosome 7. (PMID: 12853948) Hillier L.W. … Wilson R.K. (Nature 2003) 3 4
  5. Association of genome-wide variation with the risk of incident heart failure in adults of European and African ancestry: a prospective meta-analysis from the cohorts for heart and aging research in genomic epidemiology (CHARGE) consortium. (PMID: 20445134) Smith N.L. … Vasan R.S. (Circ Cardiovasc Genet 2010) 3

Products for EVX1 Gene

Sources for EVX1 Gene

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