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EVPL Gene

protein-coding   GIFtS: 54
GCID: GC17M074002

Envoplakin

  See EVPL-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
envoplakin1 2
210 KDa Cornified Envelope Precursor Protein2 3
210 KDa Paraneoplastic Pemphigus Antigen2 3
p2102 3
EVPK2

External Ids:    HGNC: 35031   Entrez Gene: 21252   Ensembl: ENSG000001678807   OMIM: 6015905   UniProtKB: Q928173   

Export aliases for EVPL gene to outside databases

Previous GC identifers: GC17P073900 GC17M077029 GC17M074467 GC17M074600 GC17M071514 GC17M069428


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for EVPL Gene:
EVPL (envoplakin) is a protein-coding gene. Diseases associated with EVPL include dendritic cell sarcoma, and follicular dendritic cell sarcoma. GO annotations related to this gene include structural molecule activity and protein binding, bridging. An important paralog of this gene is DSP.

UniProtKB/Swiss-Prot: EVPL_HUMAN, Q92817
Function: Component of the cornified envelope of keratinocytes. May link the cornified envelope to desmosomes and
intermediate filaments

Gene Wiki entry for EVPL (Envoplakin) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000017.10  NC_018928.2  NT_010783.16  
Regulatory elements:
   Regulatory transcription factor binding sites in the EVPL gene promoter:
         AhR   MyoD   AP-4   E47   RORalpha1   PPAR-gamma1   HOXA5   PPAR-gamma2   NF-kappaB1   ATF6   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidEVPL promoter sequence
   Search Chromatin IP Primers for EVPL

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat EVPL


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 17q25   Ensembl cytogenetic band:  17q25.1   HGNC cytogenetic band: 17q25

EVPL Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
EVPL gene location

GeneLoc information about chromosome 17         GeneLoc Exon Structure

GeneLoc location for GC17M074002:  view genomic region     (about GC identifiers)

Start:
74,000,583 bp from pter      End:
74,023,533 bp from pter
Size:
22,951 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: EVPL_HUMAN, Q92817 (See protein sequence)
Recommended Name: Envoplakin  
Size: 2033 amino acids; 231604 Da
Subunit: May form a homodimer or a heterodimer with PPL
Secondary accessions: A0AUV5

Explore the universe of human proteins at neXtProt for EVPL: NX_Q92817

Explore proteomics data for EVPL at MOPED

Post-translational modifications: 

  • Substrate of transglutaminase. Some glutamines and lysines are cross-linked to other envoplakin molecules, to
    other proteins such as keratin, desmoplakin, periplakin and involucrin, and to lipids like omega-hydroxyceramide1
  • Ubiquitination2 at Lys1467
  • Modification sites at PhosphoSitePlus

  • See EVPL Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_001979.2  
    ENSEMBL proteins: 
     ENSP00000467717   ENSP00000301607   ENSP00000465630  

    EVPL Human Recombinant Protein Products:

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    Cloud-Clone Corp. Proteins for EVPL

     
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    antibodies-online antibodies for EVPL 

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    antibodies-online kits for EVPL (16 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    2 InterPro protein domains:
     IPR018159 Spectrin/alpha-actinin
     IPR001101 Plectin_repeat

    Graphical View of Domain Structure for InterPro Entry Q92817

    ProtoNet protein and cluster: Q92817

    1 Blocks protein domain: IPB001101 Plectin repeat

    UniProtKB/Swiss-Prot: EVPL_HUMAN, Q92817
    Similarity: Belongs to the plakin or cytolinker family
    Similarity: Contains 7 plectin repeats
    Similarity: Contains 1 spectrin repeat


    Find genes that share domains with EVPL           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: EVPL_HUMAN, Q92817
    Function: Component of the cornified envelope of keratinocytes. May link the cornified envelope to desmosomes and
    intermediate filaments
    Induction: During differentiation of epidermal keratinocytes

         Genatlas biochemistry entry for EVPL:
    envoplakin,membrane-associated precursor of the epidermal cornified envelope,210 kDa,plakin family of cell
    junction proteins,paraneoplastic pemphigus antigen complex, homolog to DSP (see symbol)

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005198structural molecule activity IDA10908733
    GO:0030674protein binding, bridging IDA10908733
         
    Find genes that share ontologies with EVPL           About GenesLikeMe


    Phenotypes:
         1 MGI mutant phenotype (inferred from 1 allele(MGI details for Evpl):
     integument 

    Find genes that share phenotypes with EVPL           About GenesLikeMe

    Animal Models:
       genOway: Develop your customized and physiologically relevant rodent model for EVPL

    miRNA
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    EVPL_HUMAN, Q92817: Cell junction, desmosome. Cornified envelope. Cytoplasm, cytoskeleton. Note=Colocalized with
    DSP at desmosomes and along intermediate filaments
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytoskeleton5
    nucleus3
    cytosol2
    endoplasmic reticulum1
    extracellular1
    mitochondrion1
    peroxisome1
    plasma membrane1

    Gene Ontology (GO): 5 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001533cornified envelope IDA10908733
    GO:0005737cytoplasm IEA--
    GO:0005856cytoskeleton ----
    GO:0030057desmosome IEA--
    GO:0070062extracellular vesicular exosome IDA19056867

    Find genes that share ontologies with EVPL           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for EVPL About    
    See pathways by source

    SuperPathContained pathways About
    1Cytoskeleton remodeling Keratin filaments
    Cytoskeleton remodeling Keratin filaments

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 GeneGo (Thomson Reuters) Pathway for EVPL
        Cytoskeleton remodeling Keratin filaments


        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for EVPL
    Interactions:

        GeneGlobe Interaction Network for EVPL

    STRING Interaction Network Preview (showing 5 interactants - click image to see 16)

    Selected Interacting proteins for EVPL (Q928173 ENSP000003016074) via UniProtKB, MINT, STRING, and/or I2D (see all 22)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    PSORS1C2Q9UIG43, ENSP000002598454I2D: score=1 STRING: ENSP00000259845
    ENSG00000206459Q9UIG43I2D: score=1 
    ENSG00000224544Q9UIG43I2D: score=1 
    ENSG00000227246Q9UIG43I2D: score=1 
    ENSG00000232127Q9UIG43I2D: score=1 
    About this table

    Gene Ontology (GO): 4 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0008544epidermis development TAS8707850
    GO:0018149peptide cross-linking IDA10908733
    GO:0030216keratinocyte differentiation IDA10908733
    GO:0031424keratinization IEA--

    Find genes that share ontologies with EVPL           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for EVPL



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for EVPL gene: 
    NM_001988.2  

    Unigene Cluster for EVPL:

    Envoplakin
    Hs.500635  [show with all ESTs]
    Unigene Representative Sequence: BC143813
    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000589231 ENST00000301607(uc002jqi.2 uc010wss.1 uc010wst.1)
    ENST00000586740 ENST00000587569 ENST00000593037
    miRNA
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    Additional mRNA sequence: 

    AK290333.1 BC126103.1 BC126105.1 BC143813.1 BC143814.1 U53786.1 

    3 DOTS entries:

    DT.211871  DT.95264076  DT.91762478 

    Selected AceView cDNA sequences (see all 63):

    NM_001988 BX114092 CA488199 BG261307 AA905496 U53786 BM726282 AA403029 
    BU178731 AI191863 AW513830 BG122006 AA399194 BM680888 AA622249 AA158387 
    BP353801 AW752976 BP357581 AI378808 BE163557 AA029419 BG993240 AI077490 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    EVPL expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GTGATGGGCT
    EVPL Expression
    About this image


    EVPL expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 3) fully expand
     
     Epithelial Cells
             Granular Keratinocytes Stratified Epidermis
     
     Epidermis (Integumentary System)    fully expand to see all 2 entries
             Granular Keratinocytes Stratified Epidermis
     
     Skeletal Muscle (Muscoskeletal System)    fully expand to see all 2 entries
             Mononuclear Myocytes Hyoid Arch Muscles
    EVPL Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    EVPL Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.500635

    UniProtKB/Swiss-Prot: EVPL_HUMAN, Q92817
    Tissue specificity: Exclusively expressed in stratified squamous epithelia

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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for EVPL gene from Selected species (see all 16)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Evpl1 , 5 envoplakin1, 5 83.6(n)1
    82.91(a)1
      11 (81.02 cM)5
    140271  NM_025276.31  NP_079552.31 
     1162205595 
    chicken
    (Gallus gallus)
    Aves EVPL1 envoplakin 67.97(n)
    62.67(a)
      427805  XM_004946125.1  XP_004946182.1 
    lizard
    (Anolis carolinensis)
    Reptilia --
    Uncharacterized protein
    61(a)
    1 → many
    2(113247806-113303881)
    African clawed frog
    (Xenopus laevis)
    Amphibia BJ067161.12   -- 76.25(n)    BJ067161.1 
    zebrafish
    (Danio rerio)
    Actinopterygii sbcb7422 sbcb742 75.16(n)   373136  57043629 
    fruit fly
    (Drosophila melanogaster)
    Insecta shot6
    short stop
    4(a)
    1 → many
    2R(9751742-9829615)
    worm
    (Caenorhabditis elegans)
    Secernentea vab-106
    Protein VAB-10, isoform g (vab-10) mRNA, complete ...
    7(a)
    1 → many
    I(11747428-11792118) WBGene00006876


    ENSEMBL Gene Tree for EVPL (if available)
    TreeFam Gene Tree for EVPL (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for EVPL gene
    DSP2  MACF12  EVPLL2  EPPK12  PPL2  DST2  PLEC2  
    2 SIMAP similar genes for EVPL using alignment to 4 protein entries:     EVPL_HUMAN (see all proteins):
    EVPLL    PPL

    Find genes that share paralogs with EVPL           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for EVPL (see all 824)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 17 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1485026011,2
    Cuntested174003809(+) CGATAA/G/TGGAAG 2 P L mis11NA 4552
    rs98964271,2
    C,F,A,H--74002611(+) tcaccG/Atgttc 1 -- ds50018Minor allele frequency- A:0.14NA NS WA CSA 163
    rs178816301,2
    C,F--74002655(+) CACCCG/ACCTTG 1 -- ds50014Minor allele frequency- A:0.12NS WA NA EA 504
    rs99048681,2
    C,F,A--74002678(+) gctggG/Tattac 1 -- ds50010--------
    rs25984221,2
    C,F,O,H--74002725(-) TATGGT/CTTAAA 1 -- ds500123Minor allele frequency- C:0.33NA NS EA 2516
    rs178784531,2
    C,F--74002769(+) CCCGCACTCAAGGA
    GGCACAGC
    /-
    CCTCC
    1 -- ds50011Minor allele frequency- -:0.11NS 154
    rs777486671,2
    --74002783(+) GGCACC/AGCCCT 1 -- ds50011Minor allele frequency- A:0.00CSA 1
    rs1903537161,2
    --74002791(+) CCTCCC/GAGGAT 1 -- ds50010--------
    rs1833557901,2
    --74002908(+) GTGAAC/TGAATG 1 -- ds50010--------
    rs1480024041,2
    C--74002929(+) TGGCAC/TGGGGA 1 -- ut310--------

    HapMap Linkage Disequilibrium report for EVPL (74000583 - 74023533 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 6 variations for EVPL:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv817774CNV Loss17921354
    nsv908826CNV Loss21882294
    nsv833546CNV Loss17160897
    nsv908825CNV Loss21882294
    nsv908824CNV Loss21882294
    dgv3270n71CNV Loss21882294

    Human Gene Mutation Database (HGMD): EVPL
    Site Specific Mutation Identification with PCR Assays
    Search QIAGEN SeqTarget long-range PCR primers for resequencing EVPL
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 601590    OMIM disorders: --

    10 diseases for EVPL:    
    About MalaCards
    dendritic cell sarcoma    follicular dendritic cell sarcoma    nonepidermolytic palmoplantar keratoderma    paraneoplastic pemphigus
    pemphigus vulgaris    pemphigus foliaceus    castleman's disease    pemphigus
    palmoplantar keratoderma, epidermolytic    thymoma

    3 diseases from the University of Copenhagen DISEASES database for EVPL:
    Leukemia     Bullous pemphigoid     Nonepidermolytic palmoplantar keratoderma

    Find genes that share disorders with EVPL           About GenesLikeMe

    10 Novoseek inferred disease relationships for EVPL gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    pemphigus 93.3 19 11286623 (4), 19737550 (2), 10321593 (1), 9856851 (1) (see all 14)
    pemphigus foliaceus 88.6 1 10951291 (1)
    pemphigus vulgaris 85.9 1 19737550 (1)
    pemphigoid bullous 85.6 19 15243525 (1), 8938451 (1), 9699735 (1), 16120143 (1) (see all 15)
    palmoplantar keratoderma, epidermolytic 78.5 3 15756445 (2), 8938451 (1)
    skin diseases bullous 74 1 18790674 (1)
    thymoma 32.8 2 16120143 (1)
    sarcoma 29.7 2 16120143 (1)
    autoimmune diseases 28.1 2 9284106 (1)
    cancer 0 3 15756445 (2), 8938451 (1)


    Export disorders for EVPL gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for EVPL gene, integrated from 10 sources (see all 68):
    (articles sorted by number of sources associating them with EVPL)
        Utopia: connect your pdf to the dynamic
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    1. Envoplakin, a possible candidate gene for focal NEPPK/esophageal cancer (TOC): the integration of genetic and physical maps of the TOC region on 17q25. (PubMed id 10409435)1, 2, 3, 9 Risk J.M.... Field J.K. (Genomics 1999)
    2. Chromosomal localisation of the human envoplakin gene (EVPL) to the region of the tylosis oesophageal cancer gene (TOCG) on 17q25. (PubMed id 8938451)1, 3, 9 Ruhrberg C....Watt F.M. (Genomics 1996)
    3. Envoplakin, a novel precursor of the cornified envelope that has homology to desmoplakin. (PubMed id 8707850)1, 2, 9 Ruhrberg C.... Watt F.M. (J. Cell Biol. 1996)
    4. Ceramides are bound to structural proteins of the human foreskin epidermal cornified cell envelope. (PubMed id 9651377)1, 2, 9 Marekov L.N. and Steinert P.M. (J. Biol. Chem. 1998)
    5. Tryptic digestion of ubiquitin standards reveals an improved strategy for identifying ubiquitinated proteins by mass spectrometry. (PubMed id 17370265)1, 2 Denis N.J.... Figeys D. (Proteomics 2007)
    6. Co-assembly of envoplakin and periplakin into oligomers and Ca(2+)-dependent vesicle binding: implications for cornified cell envelope formation in stratified squamous epithelia. (PubMed id 15033990)1, 9 Kalinin A.E....Steven A.C. (J. Biol. Chem. 2004)
    7. Subcellular distribution of envoplakin and periplakin: insights into their role as precursors of the epidermal cornified envelope. (PubMed id 11062259)1, 9 DiColandrea T....Watt F.M. (J. Cell Biol. 2000)
    8. Infrequent mutation of the human envoplakin gene is closely linked to the tylosis oesophageal cancer locus in sporadic oesophageal squamous cell carcinomas. (PubMed id 15756445)1, 9 Iwaya T....Masuda T. (Oncol. Rep. 2005)
    9. Interaction of periplakin and envoplakin with intermediate filaments. (PubMed id 12432088)1, 9 Karashima T. and Watt F.M. (J. Cell. Sci. 2002)
    10. Periplakin, a novel component of cornified envelopes and desmosomes that belongs to the plakin family and forms complexes with envoplakin. (PubMed id 9412476)1, 9 Ruhrberg C.... Watt F.M. (J. Cell Biol. 1997)

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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 2125 HGNC: 3503 AceView: EVPL Ensembl:ENSG00000167880 euGenes: HUgn2125
    ECgene: EVPL H-InvDB: EVPL

    (According to HUGE)
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    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for EVPL Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
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    Patent Information for EVPL gene:
    Search GeneIP for patents involving EVPL

    GeneCards and IP:
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