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Aliases for EVPL Gene

Aliases for EVPL Gene

  • Envoplakin 2 3 3 5
  • 210 KDa Cornified Envelope Precursor Protein 3 4
  • 210 KDa Paraneoplastic Pemphigus Antigen 3 4
  • EVPK 3
  • P210 4

External Ids for EVPL Gene

Previous GeneCards Identifiers for EVPL Gene

  • GC17P073900
  • GC17M077029
  • GC17M074467
  • GC17M074600
  • GC17M071514
  • GC17M074002
  • GC17M069428

Summaries for EVPL Gene

Entrez Gene Summary for EVPL Gene

  • This gene encodes a member of the plakin family of proteins that forms a component of desmosomes and the epidermal cornified envelope. This gene is located in the tylosis oesophageal cancer locus on chromosome 17q25, and its deletion is associated with both familial and sporadic forms of oesophageal squamous cell carcinoma. Patients suffering from the autoimmune mucocutaneous disorder, paraneoplastic pemphigus, develop antibodies against the encoded protein. [provided by RefSeq, Jul 2016]

GeneCards Summary for EVPL Gene

EVPL (Envoplakin) is a Protein Coding gene. Diseases associated with EVPL include Paraneoplastic Pemphigus and Pemphigus. Among its related pathways are Developmental Biology and Cytoskeleton remodeling Neurofilaments. GO annotations related to this gene include structural molecule activity and intermediate filament binding. An important paralog of this gene is PPL.

UniProtKB/Swiss-Prot for EVPL Gene

  • Component of the cornified envelope of keratinocytes. May link the cornified envelope to desmosomes and intermediate filaments.

Gene Wiki entry for EVPL Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for EVPL Gene

Genomics for EVPL Gene

Regulatory Elements for EVPL Gene

Enhancers for EVPL Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH17F076026 1.4 FANTOM5 ENCODE 7.4 -0.9 -872 4.1 HDGF PKNOX1 MLX ZFP64 ARID4B SIN3A FEZF1 DMAP1 ZNF2 ZNF548 NT5C NUP85 UNK ENSG00000266980 HMGN2P43 ENSG00000264829 CDK3 TEN1 METTL23 MYO15B
GH17F075958 0.8 ENCODE 12.6 +67.7 67673 1.9 CTCF TFAP4 PKNOX1 ATF1 SAP130 ARID4B ZNF2 RAD21 GATA3 SMC3 CDK3 EVPL ACOX1 MRPL38 EXOC7 AANAT UBE2O ENSG00000267615 TEN1 TEN1-CDK3
GH17F076052 0.8 ENCODE 12.2 -26.7 -26692 2.4 KLF1 JUN ZIC2 ZFHX2 CTBP1 POLR2A HSF1 SCRT2 NFE2 FOSL2 MFSD11 EVPL CDK3 SRP68 EXOC7 ENSG00000266980 MRPL38 QRICH2 METTL23 FBF1
GH17F076070 1.3 FANTOM5 ENCODE 6.2 -44.6 -44561 2.5 HDGF PKNOX1 CREB3L1 MLX ARID4B SIN3A YY1 SLC30A9 ZNF207 ZNF143 NUP85 UNK NT5C SRP68 ENSG00000266980 TRIM65 ENSG00000267546 EVPL RNF157 UBALD2
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around EVPL on UCSC Golden Path with GeneCards custom track

Promoters for EVPL Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

Genomic Location for EVPL Gene

76,004,502 bp from pter
76,027,452 bp from pter
22,951 bases
Minus strand

Genomic View for EVPL Gene

Genes around EVPL on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
EVPL Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for EVPL Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for EVPL Gene

Proteins for EVPL Gene

  • Protein details for EVPL Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein Accession:
    Secondary Accessions:
    • A0AUV5

    Protein attributes for EVPL Gene

    2033 amino acids
    Molecular mass:
    231604 Da
    Quaternary structure:
    • May form a homodimer or a heterodimer with PPL.

    Three dimensional structures from OCA and Proteopedia for EVPL Gene

neXtProt entry for EVPL Gene

Post-translational modifications for EVPL Gene

  • Substrate of transglutaminase. Some glutamines and lysines are cross-linked to other envoplakin molecules, to other proteins such as keratin, desmoplakin, periplakin and involucrin, and to lipids like omega-hydroxyceramide (PubMed:9651377).
  • Ubiquitination at Lys 1467
  • Modification sites at PhosphoSitePlus

Other Protein References for EVPL Gene

Antibody Products

No data available for DME Specific Peptides for EVPL Gene

Domains & Families for EVPL Gene

Gene Families for EVPL Gene

Protein Domains for EVPL Gene

Suggested Antigen Peptide Sequences for EVPL Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the plakin or cytolinker family.
  • Contains 7 plectin repeats.
  • Belongs to the plakin or cytolinker family.
  • Contains 7 plectin repeats.
  • Contains 1 spectrin repeat.
genes like me logo Genes that share domains with EVPL: view

Function for EVPL Gene

Molecular function for EVPL Gene

GENATLAS Biochemistry:
envoplakin,membrane-associated precursor of the epidermal cornified envelope,210 kDa,plakin family of cell junction proteins,paraneoplastic pemphigus antigen complex, homolog to DSP (see symbol)
UniProtKB/Swiss-Prot Function:
Component of the cornified envelope of keratinocytes. May link the cornified envelope to desmosomes and intermediate filaments.
UniProtKB/Swiss-Prot Induction:
During differentiation of epidermal keratinocytes.

Gene Ontology (GO) - Molecular Function for EVPL Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005198 structural molecule activity IEA,IDA 10908733
GO:0019215 intermediate filament binding IEA --
GO:0030674 protein binding, bridging IDA 10908733
GO:0098641 cadherin binding involved in cell-cell adhesion IDA 25468996
genes like me logo Genes that share ontologies with EVPL: view
genes like me logo Genes that share phenotypes with EVPL: view

Animal Models for EVPL Gene

MGI Knock Outs for EVPL:

Animal Model Products

Inhibitory RNA Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for EVPL Gene

Localization for EVPL Gene

Subcellular locations from UniProtKB/Swiss-Prot for EVPL Gene

Cell junction, desmosome. Cornified envelope. Cytoplasm, cytoskeleton. Note=Colocalized with DSP at desmosomes and along intermediate filaments.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for EVPL gene
Compartment Confidence
plasma membrane 5
extracellular 5
cytoskeleton 5
cytosol 5
nucleus 3
mitochondrion 1
peroxisome 1
endoplasmic reticulum 1

Gene Ontology (GO) - Cellular Components for EVPL Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001533 cornified envelope IDA 10908733
GO:0005737 cytoplasm IDA --
GO:0005856 cytoskeleton IEA --
GO:0005913 cell-cell adherens junction IDA 25468996
GO:0030054 cell junction IEA --
genes like me logo Genes that share ontologies with EVPL: view

Pathways & Interactions for EVPL Gene

genes like me logo Genes that share pathways with EVPL: view

Pathways by source for EVPL Gene

1 Reactome pathway for EVPL Gene
1 GeneGo (Thomson Reuters) pathway for EVPL Gene

Gene Ontology (GO) - Biological Process for EVPL Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008544 epidermis development IEA,TAS 8707850
GO:0018149 peptide cross-linking IDA 10908733
GO:0030216 keratinocyte differentiation IDA 10908733
GO:0031424 keratinization IEA --
GO:0098609 cell-cell adhesion IEA --
genes like me logo Genes that share ontologies with EVPL: view

No data available for SIGNOR curated interactions for EVPL Gene

Transcripts for EVPL Gene

Unigene Clusters for EVPL Gene

Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for EVPL Gene

No ASD Table

Relevant External Links for EVPL Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for EVPL Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for EVPL Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for EVPL Gene

This gene is overexpressed in Esophagus - Mucosa (x16.1), Skin - Sun Exposed (Lower leg) (x9.1), Skin - Not Sun Exposed (Suprapubic) (x8.6), and Vagina (x5.7).

Protein differential expression in normal tissues from HIPED for EVPL Gene

This gene is overexpressed in Cervix (33.1), Esophagus (10.6), and Saliva (8.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for EVPL Gene

NURSA nuclear receptor signaling pathways regulating expression of EVPL Gene:


SOURCE GeneReport for Unigene cluster for EVPL Gene:


mRNA Expression by UniProt/SwissProt for EVPL Gene:

Tissue specificity: Exclusively expressed in stratified squamous epithelia.
genes like me logo Genes that share expression patterns with EVPL: view

Primer Products

No data available for Protein tissue co-expression partners for EVPL Gene

Orthologs for EVPL Gene

This gene was present in the common ancestor of animals.

Orthologs for EVPL Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia EVPL 34 35
  • 98.82 (n)
(Canis familiaris)
Mammalia EVPL 34
  • 87.98 (n)
-- 35
  • 85 (a)
(Bos Taurus)
Mammalia EVPL 34 35
  • 86.64 (n)
(Monodelphis domestica)
Mammalia -- 35
  • 84 (a)
-- 35
  • 80 (a)
-- 35
  • 63 (a)
(Mus musculus)
Mammalia Evpl 34 16 35
  • 83.6 (n)
(Rattus norvegicus)
Mammalia Evpl 34
  • 83.05 (n)
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 68 (a)
(Gallus gallus)
Aves EVPL 34
  • 67.97 (n)
-- 35
  • 62 (a)
(Anolis carolinensis)
Reptilia -- 35
  • 61 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia evpl 34
  • 59.15 (n)
(Danio rerio)
Actinopterygii evpla 34 35
  • 51.58 (n)
evplb 35
  • 40 (a)
sbcb742 34
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.10086 34
fruit fly
(Drosophila melanogaster)
Insecta shot 35
  • 4 (a)
(Caenorhabditis elegans)
Secernentea vab-10 35
  • 7 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 22 (a)
Species where no ortholog for EVPL was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for EVPL Gene

Gene Tree for EVPL (if available)
Gene Tree for EVPL (if available)

Paralogs for EVPL Gene

Paralogs for EVPL Gene

(2) SIMAP similar genes for EVPL Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with EVPL: view

Variants for EVPL Gene

Sequence variations from dbSNP and Humsavar for EVPL Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type
rs755302072 Benign 76,023,539(+) GCCGC(C/T)GGGCC reference, missense
rs777067468 Benign 76,009,079(+) GACCA(A/C)CACCT reference, missense
rs10445216 -- 76,022,516(+) GCCCG(C/T)ACTGG reference, missense
rs10696274 -- 76,020,614(+) AACCG(-/T/TT)TTTTT intron-variant
rs1076871 -- 76,010,055(-) ATCTC(A/G)GCCCG reference, synonymous-codon

Structural Variations from Database of Genomic Variants (DGV) for EVPL Gene

Variant ID Type Subtype PubMed ID
nsv833546 CNV loss 17160897
nsv817774 CNV loss 17921354

Variation tolerance for EVPL Gene

Residual Variation Intolerance Score: 95.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 9.22; 88.04% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for EVPL Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for EVPL Gene

Disorders for EVPL Gene

MalaCards: The human disease database

(7) MalaCards diseases for EVPL Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
paraneoplastic pemphigus
pemphigus foliaceus
  • pf
bullous pemphigoid
  • benign pemphigus
palmoplantar keratoderma, epidermolytic
  • palmoplantar keratoderma, nonepidermolytic
- elite association - COSMIC cancer census association via MalaCards
Search EVPL in MalaCards View complete list of genes associated with diseases

Relevant External Links for EVPL

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with EVPL: view

No data available for UniProtKB/Swiss-Prot and Genatlas for EVPL Gene

Publications for EVPL Gene

  1. Envoplakin, a possible candidate gene for focal NEPPK/esophageal cancer (TOC): the integration of genetic and physical maps of the TOC region on 17q25. (PMID: 10409435) Risk J.M. … Field J.K. (Genomics 1999) 2 3 4 22 64
  2. Ceramides are bound to structural proteins of the human foreskin epidermal cornified cell envelope. (PMID: 9651377) Marekov L.N. … Steinert P.M. (J. Biol. Chem. 1998) 3 4 22 64
  3. Chromosomal localisation of the human envoplakin gene (EVPL) to the region of the tylosis oesophageal cancer gene (TOCG) on 17q25. (PMID: 8938451) Ruhrberg C. … Watt F.M. (Genomics 1996) 2 3 22 64
  4. Envoplakin, a novel precursor of the cornified envelope that has homology to desmoplakin. (PMID: 8707850) Ruhrberg C. … Watt F.M. (J. Cell Biol. 1996) 3 4 22 64
  5. Detection of anti-envoplakin and anti-periplakin autoantibodies by ELISA in patients with paraneoplastic pemphigus. (PMID: 18820940) Huang Y. … Zhu X. (Arch. Dermatol. Res. 2009) 3 22 64

Products for EVPL Gene

Sources for EVPL Gene

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