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EVL Gene

protein-coding   GIFtS: 63
GCID: GC14P101219

Enah/Vasp-Like

  See EVL-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA

Quality score for the ORGUL clustered with this gene is 3

Aliases
Enah/Vasp-like1 2     ATTP5
Ena/Vasodilator-Stimulated Phosphoprotein-Like2 3     UEV35
RNB62 3     UEVLD5
Ena/VASP-Like Protein2     

External Ids:    HGNC: 202341   Entrez Gene: 514662   Ensembl: ENSG000001964057   OMIM: 6109855   UniProtKB: Q9UI083   
ORGUL members:         

Export aliases for EVL gene to outside databases

Previous GC identifers: GC14P094253 GC14P098428 GC14P098521 GC14P099601 GC14P100990 GC14P100999 GC14P080713 GC14P101018 GC14P101029 GC14P101045 GC14P101073 GC14P101110 GC14P101159


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for EVL Gene:
EVL (Enah/Vasp-like) is a protein-coding gene. Diseases associated with EVL include esophageal varix, and hypersplenism. GO annotations related to this gene include actin binding and profilin binding. An important paralog of this gene is SPRED3.

UniProtKB/Swiss-Prot: EVL_HUMAN, Q9UI08
Function: Ena/VASP proteins are actin-associated proteins involved in a range of processes dependent on
cytoskeleton remodeling and cell polarity such as axon guidance and lamellipodial and filopodial dynamics in
migrating cells. EVL enhances actin nucleation and polymerization

Gene Wiki entry for EVL (Enah/Vasp-like) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000014.8  NT_026437.13  NC_018925.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the EVL gene promoter:
         TBP   GR   FOXJ2 (long isoform)   TFIID   IRF-7A   Chx10   GR-alpha   FOXJ2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): EVL promoter sequence
   Search Chromatin IP Primers for EVL

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat EVL


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 14q32.2   Ensembl cytogenetic band:  14q32.2   HGNC cytogenetic band: 14q32.32

EVL Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
EVL gene location

GeneLoc information about chromosome 14         GeneLoc Exon Structure

GeneLoc location for GC14P101219:  view genomic region     (about GC identifiers)

Start:
100,437,786 bp from pter      End:
100,610,573 bp from pter
Size:
172,788 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: EVL_HUMAN, Q9UI08 (See protein sequence)
Recommended Name: Ena/VASP-like protein  
Size: 416 amino acids; 44620 Da
Subunit: Homotetramer (By similarity). Binds to the SH3 domains of ABL1, LYN and SRC. Also binds to profilin, with
preference for isoform IIa of PFN2, and the WW domain of APBB1/FE65. Binds to SEMA6A. Interacts, via the Pro-rich
region, with the C-terminal SH3 domain of DNMBP. Interacts with RAPH1. Binds, via the EVH1 domain, the Pro-rich
domain of Listeria monocytogenes actA (By similarity). Binds, via the EVH1 domain, the Pro-rich domain of ZYX
Miscellaneous: Required to transform actin polymerization into active movement for the propulsive force of
Listeria monocytogenes (By similarity)
Secondary accessions: A8K105 O95884 Q7Z522 Q8TBV1 Q9UF25 Q9UIC2
Alternative splicing: 2 isoforms:  Q9UI08-1   Q9UI08-2   

Explore the universe of human proteins at neXtProt for EVL: NX_Q9UI08

Explore proteomics data for EVL at MOPED

Post-translational modifications: 

  • Phosphorylated by PKA; phosphorylation abolishes binding to SH3 domains of ABL and SRC (By similarity)1
  • Ubiquitination2 at Lys27
  • Modification sites at PhosphoSitePlus

  • See EVL Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_057421.1  
    ENSEMBL proteins: 
     ENSP00000384720   ENSP00000437904   ENSP00000376652   ENSP00000450723   ENSP00000452156  
     ENSP00000451226   ENSP00000452327   ENSP00000450979   ENSP00000451821   ENSP00000451761  
    Reactome Protein details: Q9UI08

    EVL Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
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    Browse OriGene Protein Over-expression Lysates
    OriGene Custom MassSpec
    OriGene Custom Protein Services for EVL
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    Novus Biologicals EVL Protein
    Novus Biologicals EVL Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for EVL

     
    Search eBioscience for Proteins for EVL 

    EVL Antibody Products:

    EMD Millipore Mono- and Polyclonal Antibodies for the study of EVL
    Browse R&D Systems for Antibodies
    Cell Signaling Technology (CST) Antibodies for EVL 
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    Novus Biologicals EVL Antibodies
    Abcam antibodies for EVL
    Cloud-Clone Corp. Antibodies for EVL
    ThermoFisher Antibodies for EVL
    LSBio Antibodies in human, mouse, rat for EVL

    EVL Assay Products:

    Browse Kits and Assays available from EMD Millipore
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    GenScript Custom Assay Services for EVL
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for EVL
    Cloud-Clone Corp. CLIAs for EVL
    Search eBioscience for ELISAs for EVL 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    4 InterPro protein domains:
     IPR017354 Vasodilator_phosphoprotein
     IPR011993 PH_like_dom
     IPR014885 VASP_tetra
     IPR000697 WH1/EVH1

    Graphical View of Domain Structure for InterPro Entry Q9UI08

    ProtoNet protein and cluster: Q9UI08

    UniProtKB/Swiss-Prot: EVL_HUMAN, Q9UI08
    Domain: The EVH2 domain is comprised of 3 regions. Block A is a thymosin-like domain required for G-actin binding.
    The KLKR motif within this block is essential for the G-actin binding and for actin polymerization. Block B is
    required for F-actin binding and subcellular location, and Block C for tetramerization
    Similarity: Belongs to the Ena/VASP family
    Similarity: Contains 1 WH1 domain


    Find genes that share domains with EVL           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: EVL_HUMAN, Q9UI08
    Function: Ena/VASP proteins are actin-associated proteins involved in a range of processes dependent on
    cytoskeleton remodeling and cell polarity such as axon guidance and lamellipodial and filopodial dynamics in
    migrating cells. EVL enhances actin nucleation and polymerization

         Gene Ontology (GO): 4 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003779actin binding IEA--
    GO:0005515protein binding IPI10993894
    GO:0005522profilin binding ISS--
    GO:0017124SH3 domain binding ISS--
         
    Find genes that share ontologies with EVL           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for EVL:
     Increased S DNA content 

         8 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Evl):
     cardiovascular system  cellular  hematopoietic system  homeostasis/metabolism  immune system 
     mortality/aging  nervous system  normal 

    Find genes that share phenotypes with EVL           About GenesLikeMe

    Animal Models:
         MGI mouse knock-outs for EVL: Evltm1Lfr Evltm1Fbg

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for EVL
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for EVL

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for EVL
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for EVL

    miRNA
    Products:
        
    miRTarBase miRNAs that target EVL:
    hsa-mir-221-3p (MIRT046908)

    Block miRNA regulation of human, mouse, rat EVL using miScript Target Protectors
    3 qRT-PCR Assays for microRNAs that regulate EVL:
    hsa-miR-3613-3p hsa-miR-556-3p hsa-miR-3909
    SwitchGear 3'UTR luciferase reporter plasmidEVL 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for EVL
    Predesigned siRNA for gene silencing in human, mouse, rat EVL

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for EVL

    Clone
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    OriGene clones in human, mouse for EVL (see all 11)
    OriGene ORF clones in mouse, rat for EVL
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    GenScript: all cDNA clones in your preferred vector: EVL (NM_016337)
    Sino Biological Human cDNA Clone for EVL
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for EVL
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat EVL

    Cell Line
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    Browse ESI BIO Cell Lines and PureStem Progenitors for EVL 
    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for EVL


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    EVL_HUMAN, Q9UI08: Cytoplasm, cytoskeleton (By similarity). Cell projection, lamellipodium (By similarity).
    Note=Targeted to the leading edge of lamellipodia and the dital tip of stress fibers through interaction with a
    number of proteins. In activated T-cells, localizes to the F-actin collar and the distal tip of microspikes (By
    similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol4
    nucleus3
    cytoskeleton2

    Gene Ontology (GO): 5 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm ISS--
    GO:0005829cytosol TAS--
    GO:0005856cytoskeleton IEA--
    GO:0005925focal adhesion ISS--
    GO:0030027lamellipodium ISS--

    Find genes that share ontologies with EVL           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for EVL About   (see all 6)  
    See pathways by source

    SuperPathContained pathways About
    1L1CAM interactions
    Axon guidance0.63
    Developmental Biology0.63
    2TCR signaling (REACTOME)
    TCR signaling0.73
    3Translocation of ZAP-70 to Immunological synapse
    Generation of second messenger molecules0.62
    4Class I MHC mediated antigen processing and presentation
    Adaptive Immune System0.41
    5Signaling by Robo receptor
    Signaling by Robo receptor


    Find genes that share SuperPaths with EVL           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 Cell Signaling Technology (CST) Pathway for EVL
        Cytoskeletal Signaling


    2 Reactome Pathways for EVL
        Signaling by Robo receptor
    Generation of second messenger molecules


        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for EVL
    Interactions:

        GeneGlobe Interaction Network for EVL

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for EVL (Q9UI081, 2, 3 ENSP000003766524) via UniProtKB, MINT, STRING, and/or I2D (see all 66)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    RAD51Q066092, 3, ENSP000002678684MINT-7239394 I2D: score=1 STRING: ENSP00000267868
    SPTA1P025492, 3MINT-7211703 I2D: score=2 
    SPTAN1Q138131, 2, 3, ENSP000003618244EBI-346653,EBI-351450 MINT-7211689 MINT-7211745 MINT-7211676 MINT-7211761 I2D: score=3 STRING: ENSP00000361824
    APBB1O002133, ENSP000002994024I2D: score=3 STRING: ENSP00000299402
    DNMBPQ6XZF73, ENSP000003156594I2D: score=3 STRING: ENSP00000315659
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 11):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007015actin filament organization TAS9268706
    GO:0007166cell surface receptor signaling pathway NAS10993894
    GO:0007399nervous system development NAS10993894
    GO:0007411axon guidance TAS--
    GO:0008154actin polymerization or depolymerization ISS--

    Find genes that share ontologies with EVL           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for EVL



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for EVL gene: 
    NM_016337.2  

    Unigene Cluster for EVL:

    Enah/Vasp-like
    Hs.125867  [show with all ESTs]
    Unigene Representative Sequence: AL133642
    Selected Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 24):
    ENST00000402714(uc001ygt.3) ENST00000544450(uc001ygv.2) ENST00000554460
    ENST00000392920(uc001ygu.3) ENST00000557023 ENST00000553771 ENST00000555706
    ENST00000555048 ENST00000553875 ENST00000554045 ENST00000557637 ENST00000557153
    ENST00000556921 ENST00000557384 ENST00000553910 ENST00000554695 ENST00000554031
    ENST00000553799
    miRNA
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    Block miRNA regulation of human, mouse, rat EVL using miScript Target Protectors
    3 qRT-PCR Assays for microRNAs that regulate EVL:
    hsa-miR-3613-3p hsa-miR-556-3p hsa-miR-3909
    SwitchGear 3'UTR luciferase reporter plasmidEVL 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for EVL
    Predesigned siRNA for gene silencing in human, mouse, rat EVL
    Clone
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    OriGene clones in human, mouse for EVL (see all 11)
    OriGene ORF clones in mouse, rat for EVL
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: EVL (NM_016337)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for EVL
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat EVL
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for EVL
    OriGene qSTAR qPCR primer pairs in human, mouse for EVL
    Pre-validated RT2 qPCR Primer Assay in human, mouse / rat EVL
      QuantiTect SYBR Green Assays in human, mouse, rat EVL
      QuantiFast Probe-based Assays in human, mouse, rat EVL

    Additional mRNA sequence: 

    AF052504.1 AF087843.1 AF131766.1 AK091634.1 AK092467.1 AK289720.1 AK295919.1 AK301379.1 
    AL133642.1 BC023997.2 BC032358.1 BC049376.1 BC119797.1 

    Selected DOTS entries (see all 31):

    DT.419384  DT.95206376  DT.109890  DT.419381  DT.92440033  DT.100639707  DT.92440025  DT.91939137 
    DT.91930802  DT.100802338  DT.100770314  DT.100640688  DT.92440027  DT.100806234  DT.100865658  DT.100875756 
    DT.120762658  DT.101962536  DT.75188782  DT.97797343  DT.101956238  DT.120762543  DT.120762577  DT.120762611 

    Selected AceView cDNA sequences (see all 510):

    T35986 AA353410 AF087843 CD723931 AA683269 BX279545 BE796364 BQ717181 
    AA311567 AA318460 AA352880 AI161168 BU159102 CA942724 AA317256 CR605129 
    AI955894 AI360523 CD244167 AI358724 AJ346324 AI066795 BG678193 AI494465 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for EVL (see all 19)    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b ^ 5a · 5b ^ 6a · 6b · 6c ^ 7 ^ 8a · 8b ^ 9 ^ 10 ^ 11 ^ 12a · 12b · 12c ^ 13 ^ 14 ^ 15 ^ 16a · 16b ^ 17a ·
    SP1:                                                                                                                                      -     -           -   
    SP2:                                                                                                                                -     -     -           -   
    SP3:              -     -           -                             -     -                                                                                       
    SP4:              -     -           -                 -     -     -     -                                                                                       
    SP5:                    -           -                 -     -     -     -                                                                                       

    ExUns: 17b ^ 18a · 18b · 18c · 18d ^ 19 ^ 20a · 20b · 20c ^ 21 ^ 22a · 22b · 22c ^ 23a · 23b
    SP1:              -     -     -     -     -                                                   
    SP2:              -     -     -     -     -                                                   
    SP3:                                                                                          
    SP4:                                                                                          
    SP5:                                                                                          


    ECgene alternative splicing isoforms for EVL

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    EVL expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CACCACGGTG
    EVL Expression
    About this image


    EVL expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     
     Lung (Respiratory System)
             Basal Cells Trachea
    EVL Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    EVL Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.125867
        Custom PCR Arrays for EVL
    Primer
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    OriGene qPCR primer pairs and template standards for EVL
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    QuantiFast Probe-based Assays in human, mouse, rat EVL
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for EVL

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for EVL gene from Selected species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Evl1 , 5 Ena-vasodilator stimulated phosphoprotein1, 5 89.83(n)1
    94.43(a)1
      12 (59.46 cM)5
    140261  NM_001163394.11  NP_001156866.11 
     1085547205 
    chicken
    (Gallus gallus)
    Aves EVL1 Enah/Vasp-like 76.34(n)
    83.93(a)
      423453  NM_001006487.1  NP_001006487.1 
    lizard
    (Anolis carolinensis)
    Reptilia EVL6
    Enah/Vasp-like
    48(a)
    1 ↔ 1
    GL343270.1(1061955-1216228)
    African clawed frog
    (Xenopus laevis)
    Amphibia CD328058.12   -- 75.17(n)    CD328058.1 
    zebrafish
    (Danio rerio)
    Actinopterygii idibd22602 idibd2260 74.65(n)   58003  BC056325.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta ena6
    enabled
    17(a)
    1 → many
    2R(15029140-15050124)
    worm
    (Caenorhabditis elegans)
    Secernentea unc-346
    Protein UNC-34, isoform a
    25(a)
    1 → many
    V(982534-995404) WBGene00006770


    ENSEMBL Gene Tree for EVL (if available)
    TreeFam Gene Tree for EVL (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for EVL gene
    SPRED32  ENAH2  SPRED12  VASP2  SPRED22  
    5 SIMAP similar genes for EVL using alignment to 10 protein entries:     EVL_HUMAN (see all proteins):
    VASP    HOMER3    SPRED2    SPRED1    SPRED3

    Find genes that share paralogs with EVL           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

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    Selected SNPs for EVL (see all 1720)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 14 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0364654
    A colorectal cancer sample4--see VAR_0364652 P L mis40--------
    VAR_0364644
    A colorectal cancer sample4--see VAR_0364642 P L mis40--------
    rs1883804881,2
    --100529794(+) AAGTGC/TGTGTT 1 -- us2k10--------
    rs727119161,2
    C,F--100529840(+) GCAGCC/TGCAGA 1 -- us2k11Minor allele frequency- T:0.02NA 120
    rs1159762391,2
    C--100529854(+) CCAATG/TCTGCA 1 -- us2k10--------
    rs1928511551,2
    --100529865(+) TGGAAA/GAATGT 1 -- us2k10--------
    rs1381828421,2
    --100529995(+) CAGCAA/GCAAAA 1 -- us2k10--------
    rs1495225951,2
    C--100530123(+) ACATCC/TGCCAA 1 -- us2k10--------
    rs1459963951,2
    C--100530149(+) GGGCCA/GTAACG 1 -- us2k10--------
    rs1165606181,2
    C,F--100530228(+) ATGTTC/ATCTGG 1 -- us2k11Minor allele frequency- A:0.02WA 118

    HapMap Linkage Disequilibrium report for EVL (100437786 - 100610573 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 7 variations for EVL:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv902226CNV Loss21882294
    nsv524413CNV Loss19592680
    nsv526793CNV Loss19592680
    nsv527130CNV Loss19592680
    nsv902225CNV Loss21882294
    nsv832874CNV Loss17160897
    dgv142n21CNV Loss19592680

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing EVL
    DNA2.0 Custom Variant and Variant Library Synthesis for EVL

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 610985    OMIM disorders: --

    2 diseases for EVL:    
    About MalaCards
    esophageal varix    hypersplenism

    4 diseases from the University of Copenhagen DISEASES database for EVL:
    Esophageal varix     Varicose veins     Portal hypertension     Hypersplenism

    Find genes that share disorders with EVL           About GenesLikeMe

    Genetic Association Database (GAD): EVL
    Human Genome Epidemiology (HuGE) Navigator: EVL (1 document)

    Export disorders for EVL gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for EVL gene, integrated from 10 sources (see all 49):
    (articles sorted by number of sources associating them with EVL)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The orthologous human and murine semaphorin 6A-1 proteins (SEMA6A- 1/Sema6A-1) bind to the enabled/vasodilator-stimulated phosphoprotein- like protein (EVL) via a novel carboxyl-terminal zyxin-like domain. (PubMed id 10993894)1, 2, 3, 9 Klostermann A.... Behl C. (J. Biol. Chem. 2000)
    2. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (Mol. Med. 2010)
    3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    4. Lamellipodin, an Ena/VASP ligand, is implicated in the regulation of lamellipodial dynamics. (PubMed id 15469845)1, 2 Krause M.... Gertler F.B. (Dev. Cell 2004)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    6. Gene expression profiling in the human hypothalamus-pituitary-adrenal axis and full-length cDNA cloning. (PubMed id 10931946)1, 2 Hu R.-M.... Chen J.-L. (Proc. Natl. Acad. Sci. U.S.A. 2000)
    7. cAMP-dependent protein kinase phosphorylation of EVL, a Mena/VASP relative, regulates its interaction with actin and SH3 domains. (PubMed id 10945997)1, 3 Lambrechts A....Gertler F.B. (J. Biol. Chem. 2000)
    8. Development and application of a DNA microarray-based yeast two-hybrid system. (PubMed id 23275563)1 Suter B....Wanker E.E. (Nucleic Acids Res. 2013)
    9. Bcl2-associated athanogene 3 interactome analysis reveals a new role in modulating proteasome activity. (PubMed id 23824909)1 Chen Y....Ge F. (amp 2013)
    10. A cohesin-RAD21 interactome. (PubMed id 22145905)1 Panigrahi A.K....Pati D. (Biochem. J. 2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 51466 HGNC: 20234 AceView: EVL Ensembl:ENSG00000196405 euGenes: HUgn51466
    ECgene: EVL H-InvDB: EVL

    (According to HUGE)
    About This Section

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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for EVL Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for EVL gene:
    Search GeneIP for patents involving EVL

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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