Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 
or upload a file of gene symbols


Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

EVL Gene

protein-coding   GIFtS: 60
GCID: GC14P101159

Enah/Vasp-Like

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Enah/Vasp-like1 2
Ena/Vasodilator-Stimulated Phosphoprotein-Like2 3
RNB62 3
Ena/VASP-Like Protein2

External Ids:    HGNC: 202341   Entrez Gene: 514662   Ensembl: ENSG000001964057   UniProtKB: Q9UI083   

Export aliases for EVL gene to outside databases

Previous GC identifers: GC14P094253 GC14P098428 GC14P098521 GC14P099601 GC14P100990 GC14P100999 GC14P080713 GC14P101018 GC14P101029 GC14P101045 GC14P101073 GC14P101110


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for EVL Gene: 
EVL (Enah/Vasp-like) is a protein-coding gene. Diseases associated with EVL include dieulafoy lesion, and splenic abscess, and among its related super-pathways are Axon guidance and Immune System. GO annotations related to this gene include actin binding and profilin binding. An important paralog of this gene is SPRED3.

UniProtKB/Swiss-Prot: EVL_HUMAN, Q9UI08
Function: Ena/VASP proteins are actin-associated proteins involved in a range of processes dependent on
cytoskeleton remodeling and cell polarity such as axon guidance and lamellipodial and filopodial dynamics in
migrating cells. EVL enhances actin nucleation and polymerization

Gene Wiki entry for EVL (Enah/Vasp-like) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000014.8  NT_026437.12  NC_018925.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the EVL gene promoter:
         TBP   GR   FOXJ2 (long isoform)   TFIID   IRF-7A   Chx10   GR-alpha   FOXJ2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): EVL promoter sequence
   Search SABiosciences Chromatin IP Primers for EVL

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat EVL


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 14q32.2   Ensembl cytogenetic band:  14q32.2   HGNC cytogenetic band: 14q32.32

EVL Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
EVL gene location

GeneLoc information about chromosome 14         GeneLoc Exon Structure

GeneLoc location for GC14P101159:  view genomic region     (about GC identifiers)

Start:
100,437,786 bp from pter      End:
100,610,573 bp from pter
Size:
172,788 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: EVL_HUMAN, Q9UI08 (See protein sequence)
Recommended Name: Ena/VASP-like protein  
Size: 416 amino acids; 44620 Da
Subunit: Homotetramer (By similarity). Binds to the SH3 domains of ABL1, LYN and SRC. Also binds to profilin, with
preference for isoform IIa of PFN2, and the WW domain of APBB1/FE65. Binds to SEMA6A. Interacts, via the Pro-rich
region, with the C-terminal SH3 domain of DNMBP. Interacts with RAPH1. Binds, via the EVH1 domain, the Pro-rich
domain of Listeria monocytogenes actA (By similarity). Binds, via the EVH1 domain, the Pro-rich domain of ZYX
Subcellular location: Cytoplasm, cytoskeleton (By similarity). Cell projection, lamellipodium (By similarity).
Note=Targeted to the leading edge of lamellipodia and the dital tip of stress fibers through interaction with a
number of proteins. In activated T-cells, localizes to the F-actin collar and the distal tip of microspikes (By
similarity)
Miscellaneous: Required to transform actin polymerization into active movement for the propulsive force of
Listeria monocytogenes (By similarity)
Secondary accessions: A8K105 O95884 Q7Z522 Q8TBV1 Q9UF25 Q9UIC2
Alternative splicing: 2 isoforms:  Q9UI08-1   Q9UI08-2   

Explore the universe of human proteins at neXtProt for EVL: NX_Q9UI08

Explore proteomics data for EVL at MOPED 

Post-translational modifications:

  • UniProtKB: Phosphorylated by PKA; phosphorylation abolishes binding to SH3 domains of ABL and SRC (By similarity)
  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q9UI08

  • EVL Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    EVL Protein Expression
    REFSEQ proteins: NP_057421.1  
    ENSEMBL proteins: 
     ENSP00000384720   ENSP00000437904   ENSP00000376652   ENSP00000450723   ENSP00000452156  
     ENSP00000451226   ENSP00000452327   ENSP00000450979   ENSP00000451821   ENSP00000451761  
    Reactome Protein details: Q9UI08
    Human Recombinant Protein Products for EVL: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    Browse OriGene Protein Over-expression Lysates
    OriGene Custom MassSpec 
    OriGene Custom Protein Services for EVL
    GenScript Custom Purified and Recombinant Proteins Services for EVL
    Novus Biologicals EVL Protein
    Novus Biologicals EVL Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for EVL 

    Gene Ontology (GO): 5 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm ISS--
    GO:0005829cytosol TAS--
    GO:0005856cytoskeleton IEA--
    GO:0005925focal adhesion ISS--
    GO:0030027lamellipodium ISS--

    EVL for ontologies           About GeneDecksing



    EVL Antibody Products: 
    EMD Millipore Mono- and Polyclonal Antibodies for the study of EVL
    Browse R&D Systems for Antibodies
    Cell Signaling Technology (CST) Antibodies for EVL 
    OriGene Antibodies for EVL
    OriGene Custom Antibody Services for EVL
    GenScript Custom Superior Antibodies Services for EVL
    Novus Biologicals EVL Antibodies
    Abcam antibodies for EVL
    Cloud-Clone Corp. Antibodies for EVL 
    ThermoFisher Antibodies for EVL
    LSBio Antibodies in human, mouse, rat for EVL 

    Assay Products for EVL: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for EVL
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for EVL
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for EVL 
    Cloud-Clone Corp. CLIAs for EVL


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    4 InterPro protein domains:
     IPR017354 Vasodilator_phosphoprotein
     IPR011993 PH_like_dom
     IPR014885 VASP_tetra
     IPR000697 EVH1

    Graphical View of Domain Structure for InterPro Entry Q9UI08

    ProtoNet protein and cluster: Q9UI08

    UniProtKB/Swiss-Prot: EVL_HUMAN, Q9UI08
    Domain: The EVH2 domain is comprised of 3 regions. Block A is a thymosin-like domain required for G-actin binding.
    The KLKR motif within this block is essential for the G-actin binding and for actin polymerization. Block B is
    required for F-actin binding and subcellular location, and Block C for tetramerization
    Similarity: Belongs to the Ena/VASP family
    Similarity: Contains 1 WH1 domain


    EVL for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: EVL_HUMAN, Q9UI08
    Function: Ena/VASP proteins are actin-associated proteins involved in a range of processes dependent on
    cytoskeleton remodeling and cell polarity such as axon guidance and lamellipodial and filopodial dynamics in
    migrating cells. EVL enhances actin nucleation and polymerization

         Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003779actin binding IEA--
    GO:0005515protein binding IPI10993894
    GO:0005522profilin binding ISS--
    GO:0017124SH3 domain binding ISS--
         
    EVL for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for EVL:
     Increased S DNA content 

         7 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Evl):
     cardiovascular system  cellular  homeostasis/metabolism  immune system  mortality/aging 
     nervous system  normal 

    EVL for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-outs for EVL: Evltm1Lfr Evltm1Fbg

       inGenious Targeting Laboratory - Custom generated mouse model solutions for EVL 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for EVL

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for EVL 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for EVL 

    miRNA
    Products:
        
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat EVL
    3 QIAGEN miScript miRNA Assays for microRNAs that regulate EVL:
    hsa-miR-3613-3p hsa-miR-556-3p hsa-miR-3909
    SwitchGear 3'UTR luciferase reporter plasmidEVL 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for EVL
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat EVL

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for EVL
    Sirion Biotech Customized adenovirus for overexpression of EVL

    Clone
    Products:
         
    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene clones in human, mouse for EVL (see all 9)
    OriGene ORF clones in mouse, rat for EVL
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: EVL (NM_016337)
    Sino Biological Human cDNA Clone for EVL
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for EVL
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat EVL
    Sirion Biotech Customized lentivirus for stable overexpression of EVL 
                         Customized lentivirus expression plasmids for stable overexpression of EVL 

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for EVL
    Search LifeMap BioReagents cell lines for EVL
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for EVL


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for EVL About   (see all 6)                                                                                              See pathways by source

    SuperPathContained pathways About
    1Axon guidance
    Axon guidance0.69
    Developmental Biology0.69
    2Immune System
    Immune System0.56
    Adaptive Immune System0.56
    3TCR signaling
    TCR signaling0.75
    4Translocation of ZAP-70 to Immunological synapse
    Generation of second messenger molecules0.64
    5Activation of Rac
    Signaling by Robo receptor0.44

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 Cell Signaling Technology (CST) Pathway for EVL
        Cytoskeletal Signaling


    5/7        Reactome Pathways for EVL (see all 7)
        Developmental Biology
    Signaling by Robo receptor
    Adaptive Immune System
    TCR signaling
    Axon guidance



    EVL for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for EVL

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/34 Interacting proteins for EVL (Q9UI081, 2, 3 ENSP000003766524) via UniProtKB, MINT, STRING, and/or I2D (see all 34)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    SPTA1P025492, 3, ENSP000003571304MINT-7211703 I2D: score=2 STRING: ENSP00000357130
    RAD51Q066092, 3, ENSP000002678684MINT-7239394 I2D: score=1 STRING: ENSP00000267868
    SPTAN1Q138132, 3, ENSP000003618244MINT-7211689 MINT-7211745 MINT-7211676 MINT-7211761 I2D: score=3 STRING: ENSP00000361824
    APBB1O002133, ENSP000002994024I2D: score=3 STRING: ENSP00000299402
    DNMBPQ6XZF73, ENSP000003156594I2D: score=3 STRING: ENSP00000315659
    About this table

    Gene Ontology (GO): 5/8 biological process terms (GO ID links to tree view) (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007015actin filament organization TAS9268706
    GO:0007166cell surface receptor signaling pathway NAS10993894
    GO:0007399nervous system development NAS10993894
    GO:0007411axon guidance TAS--
    GO:0008154actin polymerization or depolymerization ISS--

    EVL for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for EVL

    Search CenterWatch for drugs/clinical trials and news about EVL

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for EVL gene: 
    NM_016337.2  

    Unigene Cluster for EVL:

    Enah/Vasp-like
    Hs.125867  [show with all ESTs]
    Unigene Representative Sequence: AL133642
    18/24 Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 24):
    ENST00000402714(uc001ygt.3) ENST00000544450(uc001ygv.2) ENST00000554460
    ENST00000392920(uc001ygu.3) ENST00000557023 ENST00000553771 ENST00000555706
    ENST00000555048 ENST00000553875 ENST00000554045 ENST00000557637 ENST00000557153
    ENST00000556921 ENST00000557384 ENST00000553910 ENST00000554695 ENST00000554031
    ENST00000553799
    miRNA
    Products:
         
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat EVL
    3 QIAGEN miScript miRNA Assays for microRNAs that regulate EVL:
    hsa-miR-3613-3p hsa-miR-556-3p hsa-miR-3909
    SwitchGear 3'UTR luciferase reporter plasmidEVL 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for EVL
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat EVL
    Clone
    Products:
         
    OriGene clones in human, mouse for EVL (see all 9)
    OriGene ORF clones in mouse, rat for EVL
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: EVL (NM_016337)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for EVL
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat EVL
    Sirion Biotech Customized lentivirus for stable overexpression of EVL 
                         Customized lentivirus expression plasmids for stable overexpression of EVL 
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for EVL
    OriGene qSTAR qPCR primer pairs in human, mouse for EVL
    SABiosciences RT2 qPCR Primer Assay in human, mouse / rat EVL
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat EVL
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat EVL

    Additional mRNA sequence: 

    AF052504.1 AF087843.1 AF131766.1 AK091634.1 AK092467.1 AK289720.1 AK295919.1 AK301379.1 
    AL133642.1 BC023997.2 BC032358.1 BC049376.1 BC119797.1 

    24/31 DOTS entries (see all 31):

    DT.419384  DT.95206376  DT.109890  DT.419381  DT.92440033  DT.100639707  DT.92440025  DT.91939137 
    DT.91930802  DT.100802338  DT.100770314  DT.100640688  DT.92440027  DT.100806234  DT.100865658  DT.100875756 
    DT.120762658  DT.101962536  DT.75188782  DT.97797343  DT.101956238  DT.120762543  DT.120762577  DT.120762611 

    24/510 AceView cDNA sequences (see all 510):

    BM722031 AI161168 T35986 AA318460 CR613658 BG057179 AW247329 AI494465 
    BU859696 AI341482 CD723931 BQ287865 BE328690 CD723558 AA347997 BF436473 
    AA321361 N64636 BM719090 CR602298 AJ346324 BQ548815 BX279545 BM805515 

    GeneLoc Exon Structure

    5/19 Alternative Splicing Database (ASD) splice patterns (SP) for EVL (see all 19)    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b ^ 5a · 5b ^ 6a · 6b · 6c ^ 7 ^ 8a · 8b ^ 9 ^ 10 ^ 11 ^ 12a · 12b · 12c ^ 13 ^ 14 ^ 15 ^ 16a · 16b ^ 17a ·
    SP1:                                                                                                                                      -     -           -   
    SP2:                                                                                                                                -     -     -           -   
    SP3:              -     -           -                             -     -                                                                                       
    SP4:              -     -           -                 -     -     -     -                                                                                       
    SP5:                    -           -                 -     -     -     -                                                                                       

    ExUns: 17b ^ 18a · 18b · 18c · 18d ^ 19 ^ 20a · 20b · 20c ^ 21 ^ 22a · 22b · 22c ^ 23a · 23b
    SP1:              -     -     -     -     -                                                   
    SP2:              -     -     -     -     -                                                   
    SP3:                                                                                          
    SP4:                                                                                          
    SP5:                                                                                          


    ECgene alternative splicing isoforms for EVL

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    EVL expression in normal human tissues (normalized intensities)      EVL embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CACCACGGTG
    EVL Expression
    About this image


    EVL expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/7 selected tissues (see all 7) fully expand
     
     Lymph (Hematopoietic System)    fully expand to see all 3 entries
             lymph node ; non-germinal center cells   
             Lymphnode   
     
     Uterus (Reproductive System)    fully expand to see all 2 entries
             uterus, pre-menopause ; cells in endometrial stroma   
     
     Lung (Respiratory System)    fully expand to see all 2 entries
             bronchus ; respiratory epithelial cells   
     
     Tonsil (Hematopoietic System)    fully expand to see all 2 entries
             tonsil ; non-germinal center cells   
     
     Spleen (Hematopoietic System)    fully expand to see all 2 entries
             spleen ; cells in white pulp   

    See EVL Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for EVL

    SOURCE GeneReport for Unigene cluster: Hs.125867
        SABiosciences Custom PCR Arrays for EVL
    Primer
    Products:
    OriGene qPCR primer pairs and template standards for EVL
    OriGene qSTAR qPCR primer pairs in human, mouse for EVL
    SABiosciences RT2 qPCR Primer Assay in human, mouse / rat EVL
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat EVL
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat EVL
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for EVL

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for EVL gene from 7/13 species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Evl1 , 5 Ena-vasodilator stimulated phosphoprotein1, 5 89.83(n)1
    94.43(a)1
      12 (59.46 cM)5
    140261  NM_001163394.11  NP_001156866.11 
     1085547205 
    chicken
    (Gallus gallus)
    Aves EVL1 Enah/Vasp-like 76.18(n)
    83.93(a)
      423453  NM_001006487.1  NP_001006487.1 
    lizard
    (Anolis carolinensis)
    Reptilia EVL6
    Uncharacterized protein
    47(a)
    1 ↔ 1
    GL343270.1(1061955-1216228)
    African clawed frog
    (Xenopus laevis)
    Amphibia CD328058.12   -- 75.17(n)    CD328058.1 
    zebrafish
    (Danio rerio)
    Actinopterygii idibd22602 idibd2260 74.65(n)   58003  BC056325.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta ena6
    enabled
    13(a)
    1 → many
    2R(15029140-15050124)
    worm
    (Caenorhabditis elegans)
    Secernentea unc-346
    Protein UNC-34, isoform a
    19(a)
    1 → many
    V(982534-995404)


    ENSEMBL Gene Tree for EVL (if available)
    TreeFam Gene Tree for EVL (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for EVL gene
    SPRED32  ENAH2  SPRED12  VASP2  SPRED22  
    6 SIMAP similar genes for EVL using alignment to 10 protein entries:     EVL_HUMAN (see all proteins):
    VASP    HOMER3    SPRED2    SPRED1    SPRED3    ENAH

    EVL for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/1720 SNPs in EVL are shown (see all 1720)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 14 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0364654
    A colorectal cancer sample4--see VAR_0364652 P L mis40--------
    VAR_0364644
    A colorectal cancer sample4--see VAR_0364642 P L mis40--------
    rs1883804881,2
    --100529794(+) AAGTGC/TGTGTT 1 -- us2k10--------
    rs727119161,2
    C,F--100529840(+) GCAGCC/TGCAGA 1 -- us2k11Minor allele frequency- T:0.02NA 120
    rs1159762391,2
    C--100529854(+) CCAATG/TCTGCA 1 -- us2k10--------
    rs1928511551,2
    --100529865(+) TGGAAA/GAATGT 1 -- us2k10--------
    rs1381828421,2
    --100529995(+) CAGCAA/GCAAAA 1 -- us2k10--------
    rs1495225951,2
    C--100530123(+) ACATCC/TGCCAA 1 -- us2k10--------
    rs1459963951,2
    C--100530149(+) GGGCCA/GTAACG 1 -- us2k10--------
    rs1165606181,2
    C,F--100530228(+) ATGTTC/ATCTGG 1 -- us2k11Minor allele frequency- A:0.02WA 118

    HapMap Linkage Disequilibrium report for EVL (100437786 - 100610573 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 7 variations for EVL:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv902226CNV Loss21882294
    nsv524413CNV Loss19592680
    nsv526793CNV Loss19592680
    nsv527130CNV Loss19592680
    nsv902225CNV Loss21882294
    nsv832874CNV Loss17160897
    dgv142n21CNV Loss19592680

    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing EVL
    DNA2.0 Custom Variant and Variant Library Synthesis for EVL

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    13 diseases for EVL:    About MalaCards
    dieulafoy lesion    splenic abscess    esophageal varix    hypersplenism
    portal hypertension    wiskott-aldrich syndrome    liver cirrhosis    hypertension
    esophagitis    colorectal cancer    gastric cancer    endotheliitis
    breast cancer

    4 diseases from the University of Copenhagen DISEASES database for EVL:
    Esophageal varix     Varicose veins     Portal hypertension     Hypersplenism

    EVL for disorders           About GeneDecksing

    Genetic Association Database (GAD): EVL
    Human Genome Epidemiology (HuGE) Navigator: EVL (1 document)

    Export disorders for EVL gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for EVL gene, integrated from 9 sources (see all 49):
    (articles sorted by number of sources associating them with EVL)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The orthologous human and murine semaphorin 6A-1 proteins (SEMA6A- 1/Sema6A-1) bind to the enabled/vasodilator-stimulated phosphoprotein- like protein (EVL) via a novel carboxyl-terminal zyxin-like domain. (PubMed id 10993894)1, 2, 3, 9 Klostermann A.... Behl C. (2000)
    2. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (2010)
    3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    4. Lamellipodin, an Ena/VASP ligand, is implicated in the regulation of lamellipodial dynamics. (PubMed id 15469845)1, 2 Krause M.... Gertler F.B. (2004)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    6. Gene expression profiling in the human hypothalamus-pituitary-adrenal axis and full-length cDNA cloning. (PubMed id 10931946)1, 2 Hu R.-M.... Chen J.-L. (2000)
    7. cAMP-dependent protein kinase phosphorylation of EVL, a Mena/VASP relative, regulates its interaction with actin and SH3 domains. (PubMed id 10945997)1, 3 Lambrechts A....Gertler F.B. (2000)
    8. Development and application of a DNA microarray-based yeast two-hybrid system. (PubMed id 23275563)1 Suter B....Wanker E.E. (2013)
    9. Bcl2-associated Athanogene 3 Interactome Analysis Reve als a New Role in Modulating Proteasome Activity. (PubMed id 23824909)1 Chen Y....Ge F. (2013)
    10. A cohesin-RAD21 interactome. (PubMed id 22145905)1 Panigrahi A.K....Pati D. (2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 51466 HGNC: 20234 AceView: EVL Ensembl:ENSG00000196405 euGenes: HUgn51466
    ECgene: EVL H-InvDB: EVL

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for EVL Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for EVL gene:
    Search GeneIP for patents involving EVL

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

     Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
     Browse for Gene Knock-down Tools from EMD Millipore
     Browse Small Molecules at EMD Millipore
     EMD Millipore Mono- and Polyclonal Antibodies for the study of EVL
     Browse Kits and Assays available from EMD Millipore
     Browse Purified and Recombinant Proteins at EMD Millipore
     
     EMD Millipore Custom Antibody & Bulk Services
     EMD Millipore Preclinical / Clinical Development Services
     EMD Millipore Immunoassay Services
     EMD Millipore Target Screening & Profiling Services

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
     Browse ELISpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Multiplex/Array Assay Kits/Reagents  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Protease Activity Assays and Reagents   Browse Recombinant/Natural Proteins  
     Browse Stem Cell Products   Browse Tocris Biochemicals & Compounds  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     OriGene Antibodies for EVL   OriGene RNAi products in human, mouse, rat for EVL  
     OriGene qPCR primer pairs and template standards for EVL   Browse OriGene Protein Over-expression Lysates  
     OriGene Custom Mass Spec   OriGene clones in human, mouse for EVL  
     OriGene qSTAR qPCR primer pairs in human, mouse for EVL   Browse OriGene full length recombinant human proteins expressed in human HEK293 cells  
     OriGene ORF clones in mouse, rat for EVL   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for EVL   OriGene Custom Protein Services for EVL  

     
     
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat EVL
     QIAGEN SeqTarget long-range PCR primers for resequencing EVL
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat EVL
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat EVL
     QIAGEN QuantiFast Probe-based Assays in human, mouse, rat EVL
     QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat EVL
     GenScript Custom Purified and Recombinant Proteins Services for EVL GenScript cDNA clones with any tag delivered in your preferred vector for EVL
     GenScript Custom Assay Services for EVL GenScript Custom Superior Antibodies Services for EVL
     GenScript Custom overexpressing Cell Line Services for EVL CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Antibodies & Assays for EVL 

     Regulatory tfbs in EVL promoter
     Search Chromatin IP Primers for EVL
     RT2 qPCR Primer Assay in human, mouse / rat EVL
     GNC Network for EVL
     SABiosciences Custom PCR Arrays for EVL
     Search Tocris compounds for EVL
     Browse Sino Biological Proteins and Antibodies
     Browse Sino Biological Cell Lysates
     cDNA Clones for EVL
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     EVL antibodies
     EVL proteins
     EVL lysates
     Antibodies for EVL
     See all of Abcam's Antibodies, Kits and Proteins for EVL
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins




     Proteins for EVL
     Antibodies for EVL
     ELISAs for EVL
     CLIAs for EVL
     Search LifeMap BioReagents cell lines for EVL
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for EVL
     SwitchGear 3'UTR luciferase reporter plasmids for EVL
     SwitchGear Promoter luciferase reporter plasmids for EVL
     ThermoFisher Antibodies for EVL
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat EVL
     inGenious Targeting Laboratory - Custom generated mouse model solutions for EVL
     inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for EVL
    Customized:
     lentivirus for stable overexpression of EVL
     lentivirus expression plasmids for stable overexpression of EVL
     adenovirus for overexpression of EVL
     LSBio Antibodies in human, mouse, rat for EVL
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
           
    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

    View Random Gene

    Category
    (GIFtS: 73)
    transforming growth factor, beta 1
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      EVL gene at Home site.
    hostname: 356980-web2.xennexinc.com index build: 106 solr: 1.4