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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

EVL Gene

protein-coding GIFtS: 56
GCID: GC14P101110

Enah/Vasp-like

Explore 13 diseases affiliated with
EVL via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Enah/Vasp-Like¹
RNB6¹ ² ³
Ena/Vasodilator-Stimulated Phosphoprotein-Like² ³
Ena/VASP-Like Protein²

External Ids:	HGNC: 20234¹	Entrez Gene: 51466²	Ensembl: ENSG00000196405⁷	UniProtKB: Q9UI08³

Export aliases for EVL gene to outside databases

Previous GC identifers: GC14P094253 GC14P098428 GC14P098521 GC14P099601 GC14P100990 GC14P100999 GC14P080713 GC14P101018 GC14P101029 GC14P101045 GC14P101073

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

UniProtKB/Swiss-Prot: EVL_HUMAN, Q9UI08

Function: Ena/VASP proteins are actin-associated proteins involved in a range of processes dependent on cytoskeleton

remodeling and cell polarity such as axon guidance and lamellipodial and filopodial dynamics in migrating cells. EVL

enhances actin nucleation and polymerization

Gene Wiki entry for EVL (Enah/Vasp-like)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000014.8 NC_018925.1 NT_026437.12

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the EVL gene promoter:
TBP GR FOXJ2 (long isoform) TFIID IRF-7A Chx10 GR-alpha FOXJ2
Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): EVL promoter sequence

Search SABiosciences Chromatin IP Primers for EVL

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat EVL

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 14q32.2 Ensembl cytogenetic band: 14q32.2 HGNC cytogenetic band: 14q32.32

EVL Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
EVL gene location

GeneLoc information about chromosome 14 GeneLoc Exon Structure

GeneLoc location for GC14P101110: view genomic region (about GC identifiers)

Start:	100,437,786 bp from pter	End:	100,610,573 bp from pter
Size:	172,788 bases	Orientation:	plus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: EVL_HUMAN, Q9UI08 (See protein sequence)

Recommended Name: Ena/VASP-like protein

Size: 416 amino acids; 44620 Da

Subunit: Homotetramer (By similarity). Binds to the SH3 domains of ABL1, LYN and SRC. Also binds to profilin, with

preference for isoform IIa of PFN2, and the WW domain of APBB1/FE65. Binds to SEMA6A. Interacts, via the Pro-rich

region, with the C-terminal SH3 domain of DNMBP. Interacts with RAPH1. Binds, via the EVH1 domain, the Pro-rich domain

of Listeria monocytogenes actA (By similarity). Binds, via the EVH1 domain, the Pro-rich domain of ZYX

Subcellular location: Cytoplasm, cytoskeleton (By similarity). Cell projection, lamellipodium (By similarity).

Note=Targeted to the leading edge of lamellipodia and the dital tip of stress fibers through interaction with a number

of proteins. In activated T-cells, localizes to the F-actin collar and the distal tip of microspikes (By similarity)

Miscellaneous: Required to transform actin polymerization into active movement for the propulsive force of Listeria

monocytogenes (By similarity)

Secondary accessions: A8K105 O95884 Q7Z522 Q8TBV1 Q9UF25 Q9UIC2

Alternative splicing: 2 isoforms: Q9UI08-1 Q9UI08-2

Explore the universe of human proteins at neXtProt for EVL: NX_Q9UI08

Post-translational modifications:

Phosphorylated by PKA; phosphorylation abolishes binding to SH3 domains of ABL and SRC (By similarity)¹

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_Q9UI08

EVL Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins: NP_057421.1

ENSEMBL proteins:

ENSP00000384720 ENSP00000437904 ENSP00000376652 ENSP00000450723 ENSP00000452156

ENSP00000451226 ENSP00000452327 ENSP00000450979 ENSP00000451821 ENSP00000451761

Reactome Protein details: Q9UI08
Human Recombinant Protein Products for EVL:

	Browse Purified and Recombinant Proteins at EMD Millipore
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Browse OriGene full length recombinant human proteins expressed in human HEK293 cells Browse OriGene Protein Over-expression Lysates OriGene Custom Protein Services for EVL
	GenScript Custom Purified and Recombinant Proteins Services for EVL
	Novus Biologicals EVL Protein Novus Biologicals EVL Lysate
	Browse Sino Biological Recombinant Proteins
	Browse ProSpec Recombinant Proteins
	Uscn Proteins for EVL

Gene Ontology (GO): 5 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005737	cytoplasm	ISS	--
GO:0005829	cytosol	TAS	--
GO:0005856	cytoskeleton	IEA	--
GO:0005925	focal adhesion	ISS	--
GO:0030027	lamellipodium	ISS	--

EVL for ontologies About GeneDecksing

EVL Antibody Products:

	EMD Millipore Mono- and Polyclonal Antibodies for the study of EVL
	Browse R&D Systems for Antibodies
	OriGene Antibodies (see all 2): EVL OriGene Custom Antibody Services for EVL
	GenScript Custom Superior Antibodies Services for EVL
	Novus Biologicals EVL Antibodies
	Abcam antibodies for EVL
	Uscn Antibodies for EVL
	ThermoFisher Antibodies for EVL

Assay Products for EVL:

	Browse Kits and Assays available from EMD Millipore
	OriGene Custom Immunoassay Development Browse OriGene Fluorogenic Cell Assay Kits
	Browse R&D Systems for biochemical assays
	GenScript Custom Assay Services for EVL
	Browse Enzo Life Sciences for kits & assays
	Uscn ELISAs and CLIAs for EVL

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

EVL for domains About GeneDecksing

4 InterPro domains/families:

IPR017354 Vasodilator_phosphoprotein

IPR011993 PH_like_dom

IPR014885 VASP_tetra

IPR000697 EVH1

Graphical View of Domain Structure for InterPro Entry Q9UI08

ProtoNet protein and cluster: Q9UI08

UniProtKB/Swiss-Prot: EVL_HUMAN, Q9UI08

Domain: The EVH2 domain is comprised of 3 regions. Block A is a thymosin-like domain required for G-actin binding. The

KLKR motif within this block is essential for the G-actin binding and for actin polymerization. Block B is required

for F-actin binding and subcellular location, and Block C for tetramerization

Similarity: Belongs to the Ena/VASP family

Similarity: Contains 1 WH1 domain

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Molecular Function:

UniProtKB/Swiss-Prot Summary: EVL_HUMAN, Q9UI08

Function: Ena/VASP proteins are actin-associated proteins involved in a range of processes dependent on cytoskeleton

remodeling and cell polarity such as axon guidance and lamellipodial and filopodial dynamics in migrating cells. EVL

enhances actin nucleation and polymerization

Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0003779	actin binding	IEA	--
GO:0005515	protein binding	IPI	10993894
GO:0005522	profilin binding	ISS	--
GO:0017124	SH3 domain binding	ISS	--

EVL for ontologies About GeneDecksing

Phenotypes:
1 GenomeRNAi human phenotype for EVL:

Increased S DNA content

7 MGI mutant phenotypes (inferred from 2 alleles) (MGI details for Evl):

cardiovascular system	cellular	homeostasis/metabolism	immune system	mortality/aging
nervous system	normal

EVL for phenotypes About GeneDecksing

Animal Models:
Mouse knock-outs for EVL: Evl^tm1Lfr Evl^tm1Fbg

inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for EVL

miRNA Products:		OriGene 3'-UTR Clone: EVL Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat EVL
		3 QIAGEN miScript miRNA Assays for microRNAs that regulate EVL:
		hsa-miR-3613-3p hsa-miR-556-3p hsa-miR-3909
		SwitchGear 3'UTR luciferase reporter plasmid: EVL 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for EVL (see all 7) OriGene shRNA RFP: EVL OriGene siRNA: EVL
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat EVL
		Sirion Biotech Custom design and validation of potent shRNA sequences against EVL

Gene Editing Products:			DNA2.0 Custom Protein Engineering Service for EVL
			Sirion Biotech Customized adenovirus for overexpression of EVL Sirion Biotech Customized adenovirus for potent knockdown of EVL

Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for EVL (see all 6) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for EVL (see all 2) OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: EVL (NM_016337)
		Browse Sino Biological Human cDNA Clones
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for EVL
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat EVL

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for EVL
		Search LifeMap BioReagents cell lines for EVL
		Sirion Biotech Customized stable knockdown cell line services for EVL Sirion Biotech Customized inducible knockdown cell line services for EVL Sirion Biotech Customized stable overexpressing cell line services for EVL Sirion Biotech Customized inducible overexpressing cell line services for EVL

In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for EVL

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Immune System

Immune System

1.00

Adaptive Immune System

0.59

Axon guidance

Axon guidance

1.00

Developmental Biology

0.69

TCR signaling

TCR signaling

1.00

Translocation of ZAP-70 to Immunological synapse

Generation of second messenger molecules

0.64

Activation of Rac

Signaling by Robo receptor

0.44

Pathway sources
See GeneCards unified pathways
Show all pathways

5/7 Reactome Pathways for EVL (see all 7)

	Developmental Biology
	Signaling by Robo receptor
	Adaptive Immune System
	TCR signaling
	Axon guidance

EVL for pathways About GeneDecksing

Interactions:

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for EVL

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

5/34 Interacting proteins for EVL (Q9UI08^{1, 2, 3} ENSP00000376652⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 34)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
SPTA1	P02549²^,³, ENSP00000357130⁴	MINT-7211703 I2D: score=2 STRING: ENSP00000357130
RAD51	Q06609²^,³, ENSP00000267868⁴	MINT-7239394 I2D: score=1 STRING: ENSP00000267868
SPTAN1	Q13813²^,³, ENSP00000361824⁴	MINT-7211689 MINT-7211745 MINT-7211676 MINT-7211761 I2D: score=3 STRING: ENSP00000361824
APBB1	O00213³, ENSP00000299402⁴	I2D: score=3 STRING: ENSP00000299402
DNMBP	Q6XZF7³, ENSP00000315659⁴	I2D: score=3 STRING: ENSP00000315659

About this table

Gene Ontology (GO): 5/7 biological process terms (GO ID links to tree view) (see all 7): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0007015	actin filament organization	TAS	9268706
GO:0007166	cell surface receptor signaling pathway	NAS	10993894
GO:0007399	nervous system development	NAS	10993894
GO:0007411	axon guidance	TAS	--
GO:0008154	actin polymerization or depolymerization	ISS	--

EVL for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for EVL
Search CenterWatch for drugs/clinical trials and news about EVL

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, Sirion Biotech, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for EVL gene:

NM_016337.2

Unigene Cluster for EVL:

Enah/Vasp-like

Hs.125867 [show with all ESTs]

Unigene Representative Sequence: AL133642

18/24 Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 24):

ENST00000402714(uc001ygt.3) ENST00000544450(uc001ygv.2) ENST00000554460

ENST00000392920(uc001ygu.3) ENST00000557023 ENST00000553771 ENST00000555706

ENST00000555048 ENST00000553875 ENST00000554045 ENST00000557637 ENST00000557153

ENST00000556921 ENST00000557384 ENST00000553910 ENST00000554695 ENST00000554031

ENST00000553799

miRNA Products:		OriGene 3'-UTR Clone: EVL Browse OriGene MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat EVL
		3 QIAGEN miScript miRNA Assays for microRNAs that regulate EVL:
		hsa-miR-3613-3p hsa-miR-556-3p hsa-miR-3909
		SwitchGear 3'UTR luciferase reporter plasmid: EVL 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for EVL (see all 7) OriGene shRNA RFP: EVL OriGene siRNA: EVL
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat EVL
		Sirion Biotech Custom design and validation of potent shRNA sequences against EVL

Clone Products:		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for EVL (see all 6) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for EVL (see all 2) OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: EVL (NM_016337)
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for EVL
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat EVL

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for EVL Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay in human, mouse / rat EVL
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat EVL
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat EVL

Additional cDNA sequence:

AF052504.1 AF087843.1 AF131766.1 AK091634.1 AK092467.1 AK289720.1 AK295919.1 AK301379.1

AL133642.1 BC023997.2 BC032358.1 BC049376.1 BC119797.1

24/31 DOTS entries (see all 31):

DT.419384 DT.95206376 DT.109890 DT.419381 DT.92440033 DT.100639707 DT.92440025 DT.91939137

DT.91930802 DT.100802338 DT.100770314 DT.100640688 DT.92440027 DT.100806234 DT.100865658 DT.100875756

DT.120762658 DT.101962536 DT.75188782 DT.97797343 DT.101956238 DT.120762543 DT.120762577 DT.120762611

24/510 AceView cDNA sequences (see all 510):

AA706208 AA347524 BI793234 BI838222 AA554259 AJ346324 BM967187 BX279545

AL133642 BQ636087 CD723558 AL043593 AI341482 CR613658 BU181831 CR612426

AI358724 BM457284 CD364406 BX456784 AL043592 BI756204 BM722031 BU616127

GeneLoc Exon Structure

5/19 Alternative Splicing Database (ASD) splice patterns (SP) for EVL (see all 19) About this scheme

ExUns:	1a	·	1b	^	2	^	3	^	4a	·	4b	^	5a	·	5b	^	6a	·	6b	·	6c	^	7	^	8a	·	8b	^	9	^	10	^	11	^	12a	·	12b	·	12c	^	13	^	14	^	15	^	16a	·	16b	^	17a	·
SP1:																																													-		-				-
SP2:																																											-		-		-				-
SP3:					-		-				-										-		-
SP4:					-		-				-						-		-		-		-
SP5:							-				-						-		-		-		-

ExUns:	17b	^	18a	·	18b	·	18c	·	18d	^	19	^	20a	·	20b	·	20c	^	21	^	22a	·	22b	·	22c	^	23a	·	23b
SP1:					-		-		-		-		-
SP2:					-		-		-		-		-
SP3:
SP4:
SP5:

ECgene alternative splicing isoforms for EVL

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

EVL expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: CACCACGGTG

About this image

EVL expression in embryonic tissues and stem cells
Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

1 LifeMap In Vivo Development Anatomical Compartment/Cell

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Head Mesenchyme

Branchial Arch 1

Cranial Neural Crest Cells

Neural Crest

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

See EVL Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for EVL

SOURCE GeneReport for Unigene cluster: Hs.125867

SABiosciences Custom PCR Arrays for EVL

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for EVL Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay in human, mouse / rat EVL
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat EVL
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat EVL

In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for EVL

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of animals.

Orthologs for EVL gene from 5/19 species (see all 19) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
chicken (Gallus gallus)	Aves	EVL¹	Enah/Vasp-like	76.18(n) 83.93(a)		423453 NM_001006487.1 NP_001006487.1
lizard (Anolis carolinensis)	Reptilia	EVL⁶	--	82(a)	1 ↔ 1	GL343270.1(1062922-1148626)
African clawed frog (Xenopus laevis)	Amphibia	CD328058.1²	--	75.17(n)		CD328058.1
zebrafish (Danio rerio)	Actinopterygii	idibd2260²	idibd2260	74.65(n)		58003 BC056325.1
fruit fly (Drosophila melanogaster)	Insecta	ena⁶	enabled	14(a)	1 → many	2R(15029140-15050124)

ENSEMBL Gene Tree for EVL (if available)
TreeFam Gene Tree for EVL (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for EVL gene

ENAH² VASP²

5 SIMAP similar genes for EVL using alignment to 10 protein entries: EVL_HUMAN (see all proteins):

VASP SPRED2 SPRED1 SPRED3 ENAH

EVL for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 14 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs188380488^1,2		--	100529794(+)	`AAGTGC/TGTGTT`	1	--	us2k¹		0	--	--	--	--
rs72711916^1,2	C,F	--	100529840(+)	`NNNNCC/TGCAGA`	1	--	us2k¹		1		NA	120
rs115976239^1,2	C	--	100529854(+)	`CCAATG/TCTGCA`	1	--	us2k¹		0	--	--	--	--
rs192851155^1,2		--	100529865(+)	`TGGAAA/GAATGT`	1	--	us2k¹		0	--	--	--	--
rs138182842^1,2		--	100529995(+)	`CAGCAA/GCAAAA`	1	--	us2k¹		0	--	--	--	--
rs149522595^1,2		--	100530123(+)	`ACATCC/TGCCAA`	1	--	us2k¹		0	--	--	--	--
rs145996395^1,2		--	100530149(+)	`GGGCCA/GTAACG`	1	--	us2k¹		0	--	--	--	--
rs116560618^1,2	F	--	100530228(+)	`ATGTTC/ATCTGG`	1	--	us2k¹		1		WA	118
rs185355593^1,2		--	100530304(+)	`TTAACA/GAAGCA`	1	--	us2k¹		0	--	--	--	--
rs139989256^1,2		--	100530370(+)	`TTGAAC/GCAAAA`	1	--	us2k¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for EVL (100437786 - 100610573 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for EVL: --

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing EVL

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

EVL for disorders About GeneDecksing

13 diseases for EVL: About MalaCards

dieulafoy lesion vericose veins wiskott-aldrich syndrome splenic abscess

esophageal varix hypersplenism portal hypertension liver cirrhosis

hypertension esophagitis colorectal cancer breast cancer

neuronitis

4 diseases from the University of Copenhagen DISEASES database for EVL:

Esophageal varix Varicose veins Portal hypertension Hypersplenism

Human Genome Epidemiology (HuGE) Navigator: EVL (1 document)

Export disorders for EVL gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for EVL gene, integrated from 9 sources (see all 47):
(articles sorted by number of sources associating them with EVL)

Utopia: connect your pdf to the dynamic
world of online information

The orthologous human and murine semaphorin 6A-1 proteins (SEMA6A- 1/Sema6A-1) bind to the enabled/vasodilator-stimulated phosphoprotein- like protein (EVL) via a novel carboxyl-terminal zyxin-like domain. (PubMed id 10993894)^{1, 2, 3, 9} Klostermann A.... Behl C. (2000)
Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)^{1, 2} Ota T.... Sugano S. (2004)
Lamellipodin, an Ena/VASP ligand, is implicated in the regulation of lamellipodial dynamics. (PubMed id 15469845)^{1, 2} Krause M.... Gertler F.B. (2004)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
Gene expression profiling in the human hypothalamus-pituitary-adrenal axis and full-length cDNA cloning. (PubMed id 10931946)^{1, 2} Hu R.-M.... Chen J.-L. (2000)
cAMP-dependent protein kinase phosphorylation of EVL, a Mena/VASP relative, regulates its interaction with actin and SH3 domains. (PubMed id 10945997)^{1, 3} Lambrechts A....Gertler F.B. (2000)
A cohesin-RAD21 interactome. (PubMed id 22145905)¹ Panigrahi A.K....Pati D. (2012)
Global landscape of HIV-human protein complexes. (PubMed id 22190034)¹ Jager S....Krogan N.J. (2012)
Initial characterization of the human central proteome. (PubMed id 21269460)² Burkard T.R.... Colinge J. (2011)
Biochemical analysis of the human ENA/VASP-family pro teins, MENA, VASP and EVL, in homologous recombination. (PubMed id 21398369)¹ Takaku M....Kurumizaka H. (2011)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 51466	HGNC: 20234	AceView: EVL	Ensembl:ENSG00000196405	euGenes: HUgn51466
ECgene: EVL	H-InvDB: EVL

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for EVL	Pharmacogenomics, SNPs, Pathways

Intellectual Property for EVL gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

About This Section

Patent Information for EVL gene:
Search GeneIP for patents involving EVL

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
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About This Section

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