Free for academic non-profit institutions. Other users need a Commercial license

Aliases for EVI5L Gene

Aliases for EVI5L Gene

  • Ecotropic Viral Integration Site 5-Like 2 3
  • Ecotropic Viral Integration Site 5-Like Protein 4

External Ids for EVI5L Gene

Previous GeneCards Identifiers for EVI5L Gene

  • GC19P007817
  • GC19P007802
  • GC19P007895
  • GC19P007569

Summaries for EVI5L Gene

GeneCards Summary for EVI5L Gene

EVI5L (Ecotropic Viral Integration Site 5-Like) is a Protein Coding gene. An important paralog of this gene is RABGAP1L.

UniProtKB/Swiss-Prot for EVI5L Gene

  • Functions as a GTPase-activating protein (GAP) with a broad specificity.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for EVI5L Gene

Genomics for EVI5L Gene

Regulatory Elements for EVI5L Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for EVI5L Gene

7,830,233 bp from pter
7,864,976 bp from pter
34,744 bases
Plus strand

Genomic View for EVI5L Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for EVI5L Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for EVI5L Gene

Proteins for EVI5L Gene

  • Protein details for EVI5L Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    EVI5-like protein
    Protein Accession:
    Secondary Accessions:
    • B9A6I9

    Protein attributes for EVI5L Gene

    794 amino acids
    Molecular mass:
    91376 Da
    Quaternary structure:
    • May interact with RAB10

    Alternative splice isoforms for EVI5L Gene


neXtProt entry for EVI5L Gene

Proteomics data for EVI5L Gene at MOPED

Post-translational modifications for EVI5L Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for EVI5L Gene

No data available for DME Specific Peptides for EVI5L Gene

Domains for EVI5L Gene

Suggested Antigen Peptide Sequences for EVI5L Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Q96CN4
  • The arginine and glutamine fingers are critical for the GTPase-activating mechanism, they pull out Rabs switch 2 glutamine and insert in Rabs active site.
  • Contains 1 Rab-GAP TBC domain.
genes like me logo Genes that share domains with EVI5L: view

No data available for Gene Families for EVI5L Gene

Function for EVI5L Gene

Molecular function for EVI5L Gene

UniProtKB/Swiss-Prot Function:
Functions as a GTPase-activating protein (GAP) with a broad specificity.

Gene Ontology (GO) - Molecular Function for EVI5L Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005096 GTPase activator activity IDA 17646400
GO:0005515 protein binding IPI 16189514
GO:0017137 Rab GTPase binding IPI 17646400
genes like me logo Genes that share ontologies with EVI5L: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for EVI5L

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for EVI5L Gene

Localization for EVI5L Gene

Subcellular locations from

Jensen Localization Image for EVI5L Gene COMPARTMENTS Subcellular localization image for EVI5L gene
Compartment Confidence
cytosol 2
nucleus 2

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for EVI5L Gene

Pathways for EVI5L Gene

SuperPathways for EVI5L Gene

No Data Available

Interacting Proteins for EVI5L Gene

Gene Ontology (GO) - Biological Process for EVI5L Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0033126 obsolete positive regulation of GTP catabolic process --
GO:0043547 positive regulation of GTPase activity IEA --
GO:1902018 negative regulation of cilium assembly IMP 17646400
genes like me logo Genes that share ontologies with EVI5L: view

No data available for Pathways by source for EVI5L Gene

Transcripts for EVI5L Gene

Unigene Clusters for EVI5L Gene

Ecotropic viral integration site 5-like:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for EVI5L

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for EVI5L Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7a · 7b ^ 8 ^ 9 ^ 10 ^ 11a · 11b · 11c ^ 12 ^ 13 ^ 14a · 14b ^ 15 ^ 16 ^ 17 ^ 18 ^ 19
SP1: - - -
SP2: - -

Relevant External Links for EVI5L Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for EVI5L Gene

mRNA expression in normal human tissues for EVI5L Gene

Protein differential expression in normal tissues for EVI5L Gene

This gene is overexpressed in Adrenal (45.3).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for EVI5L Gene

SOURCE GeneReport for Unigene cluster for EVI5L Gene Hs.26870

genes like me logo Genes that share expressions with EVI5L: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Expression partners for EVI5L Gene

Orthologs for EVI5L Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for EVI5L Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia EVI5L 35
  • 92.88 (n)
  • 98.51 (a)
EVI5L 36
  • 98 (a)
(Canis familiaris)
Mammalia EVI5L 35
  • 93.71 (n)
  • 98.76 (a)
EVI5L 36
  • 98 (a)
(Pan troglodytes)
Mammalia EVI5L 35
  • 99.5 (n)
  • 100 (a)
EVI5L 36
  • 100 (a)
(Mus musculus)
Mammalia Evi5l 16
Evi5l 36
  • 96 (a)
(Monodelphis domestica)
Mammalia EVI5L 36
  • 91 (a)
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 21 (a)
(Gallus gallus)
Aves EVI5L 36
  • 82 (a)
(Anolis carolinensis)
Reptilia EVI5L 36
  • 91 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia evi5l 35
  • 69.81 (n)
  • 74.44 (a)
(Danio rerio)
Actinopterygii si:ch211-239f4.1 35
  • 70.24 (n)
  • 76 (a)
EVI5L 36
  • 60 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG11727 36
  • 42 (a)
(Caenorhabditis elegans)
Secernentea eat-17 36
  • 35 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes GYL1 36
  • 16 (a)
GYP5 36
  • 17 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.3125 36
  • 44 (a)
Species with no ortholog for EVI5L:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for EVI5L Gene

Gene Tree for EVI5L (if available)
Gene Tree for EVI5L (if available)

Paralogs for EVI5L Gene

Paralogs for EVI5L Gene

Selected SIMAP similar genes for EVI5L Gene using alignment to 3 proteins: Pseudogenes for EVI5L Gene

genes like me logo Genes that share paralogs with EVI5L: view

Variants for EVI5L Gene

Sequence variations from dbSNP and Humsavar for EVI5L Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type MAF
rs12563 -- 7,864,804(-) GGGAC(A/G)GAGCA utr-variant-3-prime
rs13265 -- 7,864,738(-) GGCTC(C/T)GGGAG utr-variant-3-prime
rs473175 -- 7,852,061(-) CATCT(A/G)CGGGG intron-variant
rs473782 -- 7,845,469(-) cccca(C/T)ggaca upstream-variant-2KB, intron-variant
rs475729 -- 7,845,688(-) ATCAA(C/T)GCCAT upstream-variant-2KB, intron-variant

Structural Variations from Database of Genomic Variants (DGV) for EVI5L Gene

Variant ID Type Subtype PubMed ID
nsv833732 CNV Gain 17160897
nsv910980 CNV Loss 21882294
dgv3715n71 CNV Loss 21882294
nsv833733 CNV Gain 17160897
nsv525499 CNV Loss 19592680
nsv910984 CNV Loss 21882294
nsv910985 CNV Loss 21882294
nsv910986 CNV Loss 21882294

Relevant External Links for EVI5L Gene

HapMap Linkage Disequilibrium report
Human Gene Mutation Database (HGMD)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for EVI5L Gene

Disorders for EVI5L Gene

Relevant External Links for EVI5L

Genetic Association Database (GAD)

No disorders were found for EVI5L Gene.

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships and Genatlas for EVI5L Gene

Publications for EVI5L Gene

  1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  2. Identification and characterization of a novel Tre-2/Bub2/Cdc16 (TBC) protein that possesses Rab3A-GAP activity. (PMID: 19077034) Ishibashi K. … Fukuda M. (Genes Cells 2009) 3 4
  3. Host determinants of HIV-1 control in African Americans. (PMID: 20205591) Pelak K. … . (J. Infect. Dis. 2010) 3 48
  4. Screening for target Rabs of TBC (Tre-2/Bub2/Cdc16) domain-containing proteins based on their Rab-binding activity. (PMID: 16923123) Itoh T. … Fukuda M. (Genes Cells 2006) 3 4
  5. The Evi5 family in cellular physiology and pathology. (PMID: 23669355) Lim Y.S. … Tang B.L. (FEBS Lett. 2013) 2 3

Products for EVI5L Gene

Sources for EVI5L Gene

Back to Top