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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

EVI5L Gene

protein-coding   GIFtS: 47
GCID: GC19P007895

Ecotropic Viral Integration Site 5-Like

Microbiology & Infectious Diseases Congress
  See related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Ecotropic Viral Integration Site 5-Like1 2
Ecotropic Viral Integration Site 5-Like Protein2 3
EVI5-Like Protein2

External Ids:    HGNC: 304641   Entrez Gene: 1157042   Ensembl: ENSG000001424597   UniProtKB: Q96CN43   

Export aliases for EVI5L gene to outside databases

Previous GC identifers: GC19P007817 GC19P007802 GC19P007569


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for EVI5L Gene: 
EVI5L (ecotropic viral integration site 5-like) is a protein-coding gene. Diseases associated with EVI5L include alzheimer's disease. GO annotations related to this gene include protein binding and Rab GTPase activator activity. An important paralog of this gene is TBC1D12.

UniProtKB/Swiss-Prot: EVI5L_HUMAN, Q96CN4
Function: Functions as a GTPase-activating protein (GAP) with a broad specificity




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000019.9  NT_077812.2  NC_018930.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the EVI5L gene promoter:
         POU2F2 (Oct-2.1)   oct-B3   oct-B2   POU2F2   Gfi-1   POU2F2C   AREB6   POU2F1   POU2F1a   POU2F2B   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search SABiosciences Chromatin IP Primers for EVI5L

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat EVI5L


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19p13.2   Ensembl cytogenetic band:  19p13.2   HGNC cytogenetic band: 19p13

EVI5L Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
EVI5L gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19P007895:  view genomic region     (about GC identifiers)

Start:
7,895,119 bp from pter      End:
7,929,862 bp from pter
Size:
34,744 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: EVI5L_HUMAN, Q96CN4 (See protein sequence)
Recommended Name: EVI5-like protein  
Size: 794 amino acids; 91376 Da
Subunit: May interact with RAB10
Secondary accessions: B9A6I9
Alternative splicing: 2 isoforms:  Q96CN4-1   Q96CN4-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for EVI5L: NX_Q96CN4

Explore proteomics data for EVI5L at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q96CN4

  • EVI5L Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    EVI5L Protein Expression
    REFSEQ proteins (2 alternative transcripts): 
    NP_001153416.1  NP_660288.1  

    ENSEMBL proteins: 
     ENSP00000270530   ENSP00000445905   ENSP00000472181   ENSP00000470145  

    Human Recombinant Protein Products for EVI5L: 
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    Browse Sino Biological Cell Lysates 
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    Cloud-Clone Corp. Proteins for EVI5L 

    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005622intracellular ----

    EVI5L for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    1 InterPro protein domain:
     IPR000195 Rab-GTPase-TBC_dom

    Graphical View of Domain Structure for InterPro Entry Q96CN4

    ProtoNet protein and cluster: Q96CN4

    2 Blocks protein domains:
    IPB000195 RabGAP/TBC domain
    IPB000515 Binding-protein-dependent transport systems inner membrane component


    UniProtKB/Swiss-Prot: EVI5L_HUMAN, Q96CN4
    Similarity: Contains 1 Rab-GAP TBC domain


    EVI5L for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: EVI5L_HUMAN, Q96CN4
    Function: Functions as a GTPase-activating protein (GAP) with a broad specificity

         Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005097Rab GTPase activator activity IEA--
    GO:0005515protein binding IPI16189514
         
    EVI5L for ontologies           About GeneDecksing


    Animal Models:
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for EVI5L 
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    hsa-miR-30c hsa-miR-34b* hsa-miR-522 hsa-miR-1271 hsa-miR-200a hsa-miR-30d hsa-miR-449a hsa-miR-1205
    SwitchGear 3'UTR luciferase reporter plasmidEVI5L 3' UTR sequence
    Inhib. RNA
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for EVI5L

    STRING Interaction Network Preview (showing 1 interactants - click image to see more details)

    5/22 Interacting proteins for EVI5L (Q96CN41, 3 ENSP000002705304) via UniProtKB, MINT, STRING, and/or I2D (see all 22)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    NUDT18Q6ZVK81, 3, ENSP000003078524EBI-749523,EBI-740486 I2D: score=3 STRING: ENSP00000307852
    ENSG00000258947Q135093I2D: score=1 
    TUBB3Q135093I2D: score=1 
    SH3YL1Q96HL83I2D: score=6 
    RAB8BQ929303I2D: score=4 
    About this table

    Gene Ontology (GO): 1 biological process term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0032313regulation of Rab GTPase activity ----

    EVI5L for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for EVI5L

    Search CenterWatch for drugs/clinical trials and news about EVI5L

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for EVI5L gene (2 alternative transcripts): 
    NM_001159944.1  NM_145245.3  

    Unigene Cluster for EVI5L:

    Ecotropic viral integration site 5-like
    Hs.26870  [show with all ESTs]
    Unigene Representative Sequence: NM_145245
    7 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000270530(uc002min.3) ENST00000538904(uc010xjz.2 uc002mio.1)
    ENST00000597440 ENST00000599036 ENST00000601984 ENST00000600802 ENST00000601766

    Congresses - knowledge worth sharing:  
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

    miRNA
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    8/28 QIAGEN miScript miRNA Assays for microRNAs that regulate EVI5L (see all 28):
    hsa-miR-30c hsa-miR-34b* hsa-miR-522 hsa-miR-1271 hsa-miR-200a hsa-miR-30d hsa-miR-449a hsa-miR-1205
    SwitchGear 3'UTR luciferase reporter plasmidEVI5L 3' UTR sequence
    Inhib. RNA
    Products:
         
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    Additional mRNA sequence: 

    AB449874.1 AK091609.1 BC014111.2 HM370400.1 

    8 DOTS entries:

    DT.445809  DT.95269450  DT.100036532  DT.95088313  DT.100670115  DT.100750195  DT.91745017  DT.97831238 

    24/135 AceView cDNA sequences (see all 135):

    BQ777177 AJ708251 BQ186614 BQ957087 AI769332 Z38319 AI359135 BU557858 
    BQ268859 BX412718 CD251248 BM722689 BQ184638 BQ778293 BQ189190 BM677555 
    BQ012107 AI382542 BG150278 AI283121 BQ012122 T32165 BF195724 AW572975 

    GeneLoc Exon Structure

    3 Alternative Splicing Database (ASD) splice patterns (SP) for EVI5L    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7a · 7b ^ 8 ^ 9 ^ 10 ^ 11a · 11b · 11c ^ 12 ^ 13 ^ 14a · 14b ^ 15 ^ 16 ^ 17 ^ 18 ^ 19
    SP1:                                                                          -     -     -                                                         
    SP2:                                                                          -           -                                                         
    SP3:                                                                                                                                                


    ECgene alternative splicing isoforms for EVI5L

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    EVI5L expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TCGCCCAGGC
    EVI5L Expression
    About this image


    See EVI5L Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for EVI5L

    SOURCE GeneReport for Unigene cluster: Hs.26870
        SABiosciences Custom PCR Arrays for EVI5L
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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for EVI5L gene from 6/12 species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Evi5l1 , 5 ecotropic viral integration site 5 like1, 5 90.31(n)1
    99.74(a)1
      8 (1.95 cM)5
    2130271  NM_001039578.31  NP_001034667.31 
     41665675 
    chicken
    (Gallus gallus)
    Aves EVI5L6
    ecotropic viral integration site 5-like
    82(a)
    1 ↔ 1
    AADN03013353.1(1987-11350)
    lizard
    (Anolis carolinensis)
    Reptilia EVI5L6
    --
    Uncharacterized protein
    92(a)
    69(a)
    1 ↔ 1
    possible ortholog
    GL343286.1(305-26785)
    2(119698450-119710285)
    zebrafish
    (Danio rerio)
    Actinopterygii si:ch211-239f4.11 si:ch211-239f4.1 69.94(n)
    75.73(a)
      566318  XM_689590.5  XP_694682.5 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG117276
    --
    41(a)
    1 → many
    X(11324556-11348371)
    worm
    (Caenorhabditis elegans)
    Secernentea tbc-46
    Protein TBC-4
    43(a)
    1 → many
    X(16406207-16413306)


    ENSEMBL Gene Tree for EVI5L (if available)
    TreeFam Gene Tree for EVI5L (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for EVI5L gene
    TBC1D122  TBC1D42  TBC1D142  RABGAP1L2  TBC1D12  EVI52  RABGAP12  
    1 SIMAP similar gene for EVI5L using alignment to 3 protein entries:     EVI5L_HUMAN (see all proteins):
    EVI5

    EVI5L for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for EVI5L
    PGOHUM00000263027


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/810 SNPs in EVI5L are shown (see all 810)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 19 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1824734561,2
    --7893183(+) AGGCAC/TCCGCC 1 -- us2k10--------
    rs1879742141,2
    --7893185(+) GCACCC/TGCCTC 1 -- us2k10--------
    rs1145915611,2
    F--7893497(+) TTGAGC/ATCTCA 1 -- us2k11Minor allele frequency- A:0.01WA 118
    rs765303631,2
    C--7893528(+) TGCCCC/GTCCCT 1 -- us2k10--------
    rs1923123701,2
    --7893581(+) GCTGGA/GCGAGG 1 -- us2k10--------
    rs1842169791,2
    --7893599(+) TGCCTG/TTAATC 1 -- us2k10--------
    rs1434453601,2
    --7893697(+) CAAAAA/TAATTA 1 -- us2k10--------
    rs1467652951,2
    --7893768(+) TCATTC/GGAGTC 1 -- us2k10--------
    rs1404964591,2
    --7893778(+) CCAAGA/GGTTCG 1 -- us2k10--------
    rs1888152341,2
    --7893888(+) GTCACC/TCTCTC 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for EVI5L (7895119 - 7929862 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 8 variations for EVI5L:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv910986CNV Loss21882294
    nsv910984CNV Loss21882294
    nsv525499CNV Loss19592680
    dgv3715n71CNV Loss21882294
    nsv910985CNV Loss21882294
    nsv910980CNV Loss21882294
    nsv833733CNV Gain17160897
    nsv833732CNV Gain17160897

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    2 diseases for EVI5L:    About MalaCards
    alzheimer's disease    


    EVI5L for disorders           About GeneDecksing

    Genetic Association Database (GAD): EVI5L

    Export disorders for EVI5L gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for EVI5L gene, integrated from 9 sources (see all 11):
    (articles sorted by number of sources associating them with EVI5L)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The Evi5 family in cellular physiology and pathology. (PubMed id 23669355)1, 3 Lim Y.S. and Tang B.L. (2013)
    2. Host determinants of HIV-1 control in African America ns. (PubMed id 20205591)1, 4 Pelak K....Weintrob A.C. (2010)
    3. Identification and characterization of a novel Tre-2/Bub2/Cdc16 (TBC) protein that possesses Rab3A-GAP activity. (PubMed id 19077034)1, 2 Ishibashi K.... Fukuda M. (2009)
    4. Screening for target Rabs of TBC (Tre-2/Bub2/Cdc16) domain-containing proteins based on their Rab-binding activity. (PubMed id 16923123)1, 2 Itoh T.... Fukuda M. (2006)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    6. Interactome mapping suggests new mechanistic details u nderlying Alzheimer's disease. (PubMed id 21163940)1 Soler-Lopez M....Aloy P. (2011)
    7. An empirical framework for binary interactome mapping . (PubMed id 19060904)1 Venkatesan K....Vidal M. (2009)
    8. Towards a proteome-scale map of the human protein-protein interaction network. (PubMed id 16189514)1 Rual J.F....Vidal M. (2005)
    9. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1 Ota T.... Sugano S. (2004)
    10. The DNA sequence and biology of human chromosome 19. (PubMed id 15057824)2 Grimwood J.... Lucas S.M. (2004)

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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 115704 HGNC: 30464 AceView: EVI5L Ensembl:ENSG00000142459 euGenes: HUgn115704
    ECgene: EVI5L H-InvDB: EVI5L

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for EVI5L Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for EVI5L gene:
    Search GeneIP for patents involving EVI5L

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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