EVI5L Gene
protein-coding GIFtS: 43
GCID: GC19P007895
|
|
ecotropic viral integration site 5-like
| |
Aliases
for EVI5L gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Ecotropic Viral Integration Site 5-Like1 2 | | Ecotropic Viral Integration Site 5-Like Protein2 3 | | EVI5-Like Protein2 |
Export aliases for EVI5L gene to outside databasesPrevious GC identifers: GC19P007817 GC19P007802 GC19P007569 |
Summaries
for EVI5L gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
UniProtKB/Swiss-Prot: EVI5L_HUMAN, Q96CN4Function: Functions as a GTPase-activating protein (GAP) with a broad specificity
|
Genomic Views
for EVI5L gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000019.9 NC_018930.1 NT_077812.2
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the EVI5L gene promoter:
POU2F2 (Oct-2.1) oct-B3 oct-B2 POU2F2 Gfi-1 POU2F2C AREB6 POU2F1 POU2F1a POU2F2B
Other transcription factors
Search SABiosciences Chromatin IP Primers for EVI5L
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat EVI5L |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 19p13.2 Ensembl cytogenetic band: 19p13.2 HGNC cytogenetic band: 19p13EVI5L Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 19 GeneLoc Exon Structure GeneLoc location for GC19P007895: view genomic region
(about GC identifiers)
Start:
|
7,895,161 bp from pter |
End:
|
7,929,862 bp from pter |
Size:
|
34,702 bases |
Orientation:
|
plus strand |
|
Proteins
for EVI5L gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: EVI5L_HUMAN, Q96CN4 (See
protein sequence)Recommended Name: EVI5-like protein Size: 794 amino acids; 91376 Da
Subunit: May interact with RAB10
Secondary accessions: B9A6I9Alternative splicing: 2 isoforms: Q96CN4-1 Q96CN4-2 (No experimental confirmation available)Explore the universe of human proteins at neXtProt for EVI5L: NX_Q96CN4
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q96CN4
EVI5L Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (2 alternative transcripts):
NP_001153416.1 NP_660288.1
ENSEMBL proteins: ENSP00000270530 ENSP00000445905
Human Recombinant Protein Products for EVI5L:
Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005622 | intracellular |
IEA | -- |
EVI5L for ontologies About GeneDecksing
EVI5L Antibody Products:
Assay Products for EVI5L: |
Protein
Domains /
Families
for EVI5L gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
EVI5L for domains About GeneDecksing
1 InterPro domain/family:Graphical View of Domain Structure for InterPro Entry Q96CN4ProtoNet protein and cluster: Q96CN4 2 Blocks protein families: IPB000195 RabGAP/TBC domain IPB000515 Binding-protein-dependent transport systems inner membrane component
UniProtKB/Swiss-Prot: EVI5L_HUMAN, Q96CN4Similarity: Contains 1 Rab-GAP TBC domain |
Function
for EVI5L gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
inGenious Targeting Laboratory,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase,
shRNA from
OriGene,
Sirion Biotech,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Sirion Biotech,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
Sirion Biotech,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Molecular Function:
UniProtKB/Swiss-Prot Summary: EVI5L_HUMAN, Q96CN4Function: Functions as a GTPase-activating protein (GAP) with a broad specificity Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view): About this table
EVI5L for ontologies About GeneDecksing
Animal Models:
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for EVI5L (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for EVI5L (see all 2)
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector (see all 2): EVI5L (NM_145245) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for EVI5L | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat EVI5L |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for EVI5L |
|
Pathways & Interactions
for EVI5L gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for EVI5L
STRING Interaction
Network Preview (showing 1 interactants - click image to see more details)
5/22 Interacting proteins for EVI5L (Q96CN41, 3 ENSP000002705304) via UniProtKB, MINT, STRING, and/or I2D (see all 22)About this table
|
Drugs & Compounds
for EVI5L gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for EVI5L
Search CenterWatch for drugs/clinical trials and news about EVI5L
|
Transcripts
for EVI5L gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
Sirion Biotech,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for EVI5L gene (2 alternative transcripts): NM_001159944.1 NM_145245.3 Unigene Cluster for EVI5L: Ecotropic viral integration site 5-like Hs.26870 [show with all ESTs]Unigene Representative Sequence: NM_1452452 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000270530(uc002min.3) ENST00000538904(uc010xjz.2 uc002mio.1)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for EVI5L (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for EVI5L (see all 2)
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector (see all 2): EVI5L (NM_145245) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for EVI5L | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat EVI5L |
Additional cDNA sequence: AB449874.1 AK091609.1 BC014111.2 HM370400.1 8 DOTS entries: DT.445809 DT.95269450 DT.100036532 DT.95088313 DT.100670115 DT.100750195 DT.91745017 DT.97831238 24/135 AceView cDNA sequences (see all 135): BF195724 BQ189190 AI139560 BU557858 BQ184638 AW572975 CR613564 BM722689 AI769332 BQ957087 T32165 BQ778293 BQ186614 AI283121 BX412718 BQ777177 AJ708251 BQ268859 BQ012122 Z38319 CD251248 AI382542 AI359135 BG150278
GeneLoc Exon Structure
3 Alternative Splicing Database (ASD) splice patterns (SP) for EVI5L About this scheme
| ExUns: | 1 | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6a | · | 6b | ^ | 7a | · | 7b | ^ | 8 | ^ | 9 | ^ | 10 | ^ | 11a | · | 11b | · | 11c | ^ | 12 | ^ | 13 | ^ | 14a | · | 14b | ^ | 15 | ^ | 16 | ^ | 17 | ^ | 18 | ^ | 19 |
|---|
|
| SP1: | | | | | | | | | | | | | | | | | | | | | | | | | - | | - | | - | | | | | | | | | | | | | | | | | | | | |
| SP2: | | | | | | | | | | | | | | | | | | | | | | | | | - | | | | - | | | | | | | | | | | | | | | | | | | | |
| SP3: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for EVI5L
|
Expression
for EVI5L gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| EVI5L expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TCGCCCAGGC
About this image
See EVI5L Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for EVI5L
SOURCE GeneReport for Unigene cluster: Hs.26870
SABiosciences Custom PCR Arrays for EVI5L
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for EVI5L
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat EVI5L | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat EVI5L | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat EVI5L | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for EVI5L |
Orthologs
for EVI5L gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of eukaryotes.
Orthologs for EVI5L gene from 7/23 species (see all 23) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
chicken
(Gallus gallus) |
Aves |
EVI5L6 |
-- |
66(a) |
1 ↔ 1 |
Un(48448554-48451640) |
lizard
(Anolis carolinensis) |
Reptilia |
EVI5L6 |
-- |
93(a) |
1 ↔ 1 |
GL343286.1(412-26704) |
zebrafish
(Danio rerio) |
Actinopterygii |
si:ch211-239f4.11 |
si:ch211-239f4.1 |
69.94(n)
75.73(a) |
|
566318 XM_689590.5 XP_694682.5 |
fruit fly
(Drosophila melanogaster) |
Insecta |
CG117276 |
-- |
40(a) |
1 → many |
X(11324556-11348371) |
worm
(Caenorhabditis elegans) |
Secernentea |
tbc-46 |
TBC (Tre-2/Bub2/Cdc16) domain family member (tbc-4... |
44(a) |
1 → many |
X(16406135-16413234) |
thale cress
(Arabidopsis thaliana) |
eudicotyledons |
AT3G024606PAM16 |
plant adhesion molecule 1 |
31(a)29(a) |
possible orthologpossible ortholog |
3(505434-508428) 5(5199711-5202452) |
rice
(Oryza sativa) |
Liliopsida |
-- |
TBC domain containing protein, expressed |
29(a) |
possible ortholog |
8(19736918-19741786) |
ENSEMBL Gene Tree for EVI5L (if available)
TreeFam Gene Tree for EVI5L (if available) |
Paralogs
for EVI5L gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for EVI5L gene
- RABGAP1L2 TBC1D122 TBC1D42 TBC1D142 TBC1D12 EVI52 RABGAP12
1 SIMAP similar gene for EVI5L using alignment to 3 protein entries: EVI5L_HUMAN (see all proteins):EVI5
EVI5L for paralogs About GeneDecksing
1 Pseudogenes.org Pseudogene for EVI5L
PGOHUM00000263027
|
Genomic Variants
for EVI5L gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 19 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for EVI5L (7895161 - 7929862 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for EVI5L: -- | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing EVI5L |
|
Disorders
/ Diseases
for EVI5L gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
| -- |
Publications
for EVI5L gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for EVI5L gene integrated from 9 sources:
(articles sorted by number of sources associating them with EVI5L) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Identification and characterization of a novel Tre-2/Bub2/Cdc16 (TBC) protein that possesses Rab3A-GAP activity. (PubMed id 19077034)1, 2 Ishibashi K.... Fukuda M. (2009)
- Screening for target Rabs of TBC (Tre-2/Bub2/Cdc16) domain-containing proteins based on their Rab-binding activity. (PubMed id 16923123)1, 2 Itoh T.... Fukuda M. (2006)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Interactome mapping suggests new mechanistic details u nderlying Alzheimer's disease. (PubMed id 21163940)1 Soler-Lopez M....Aloy P. (2011)
- Host determinants of HIV-1 control in African America ns. (PubMed id 20205591)1 Pelak K....Weintrob A.C. (2010)
- An empirical framework for binary interactome mapping . (PubMed id 19060904)1 Venkatesan K....Vidal M. (2009)
- Towards a proteome-scale map of the human protein-protein interaction network. (PubMed id 16189514)1 Rual J.F....Vidal M. (2005)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1 Ota T.... Sugano S. (2004)
- The DNA sequence and biology of human chromosome 19. (PubMed id 15057824)2 Grimwood J.... Lucas S.M. (2004)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
|
External Searches for EVI5L gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing EVI5L gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing EVI5L gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing EVI5L gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for EVI5L | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for EVI5L gene:
Search GeneIP for patents involving EVI5L
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for EVI5L gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory)
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for EVI5L | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for EVI5L | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for EVI5L | | | OriGene Protein Over-expression Lysate for EVI5L | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for EVI5L | | OriGene 3'-UTR Clone for EVI5L | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for EVI5L | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for EVI5L | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | OriGene Purified Protein for EVI5L | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
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| |
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| | | | Search Tocris compounds for EVI5L |
| |  |  |  |  | | | | |
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 |
 | | | EVI5L Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for EVI5L |
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