Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 
or upload a file of gene symbols


Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

EVI5 Gene

protein-coding   GIFtS: 59
GCID: GC01M092974

ecotropic viral integration site 5

 Explore 2 diseases affiliated with
EVI5 via our new
 Human Malady Compendium 
Biological research products
for EVI5
    

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section

Aliases
Ecotropic Viral Integration Site 51 2
NB4S1 2 3 5
Neuroblastoma Stage 4S Gene Protein2 3
EVI-52 3
DJ846D11.1 (Ecotropic Viral Integration Site 5)2
Ecotropic Viral Integration Site 5 Protein Homolog2

External Ids:    HGNC: 35011   Entrez Gene: 78132   Ensembl: ENSG000000672087   OMIM: 6029425   UniProtKB: O604473   

Export aliases for EVI5 gene to outside databases

Previous GC identifers: GC01M093448 GC01M092183 GC01M092311 GC01M092446 GC01M092691 GC01M092746 GC01M091095


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

UniProtKB/Swiss-Prot: EVI5_HUMAN, O60447
Function: Functions as a regulator of cell cycle progression by stabilizing the FBXO5 protein and promoting cyclin-A
accumulation during interphase. May play a role in cytokinesis

Gene Wiki entry for EVI5


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000001.10  NC_018912.1  NT_032977.9  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the EVI5 gene promoter:
         c-Fos   p53   HNF-1A   C/EBPalpha   CHOP-10   MEF-2A   HNF-1   c-Jun   aMEF-2   RSRFC4   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): EVI5 promoter sequence
   Search SABiosciences Chromatin IP Primers for EVI5

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat EVI5


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1p22.1   Ensembl cytogenetic band:  1p22.1   HGNC cytogenetic band: 1p22

EVI5 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
EVI5 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01M092974:  view genomic region     (about GC identifiers)

Start:
92,974,253 bp from pter      End:
93,257,961 bp from pter
Size:
283,709 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: EVI5_HUMAN, O60447 (See protein sequence)
Recommended Name: Ecotropic viral integration site 5 protein homolog  
Size: 810 amino acids; 92949 Da
Subunit: Dimeric and monomeric. Interacts with alpha- and gamma-tubulin. Interacts with FBXO5. Interacts with the
chromosome passenger complex (CPC) which is at least composed of AURKB/aurora-B, BIRC5/survivin, CDCA8/borealin and
INCENP
Subcellular location: Nucleus. Cytoplasm, cytoskeleton, centrosome. Cytoplasm, cytoskeleton, spindle. Note=Associates
with the mitotic spindle through anaphase and remains within the midzone and midbody until completion of cytokinesis
Miscellaneous: Depletion of EVI5 by RNAi causes cell cycle arrest and mitotic abnormalities
Secondary accessions: A6NKX8 Q9H1Y9

Explore the universe of human proteins at neXtProt for EVI5: NX_O60447

Post-translational modifications:

  • Probably phosphorylated by PLK1; may be required for degradation during mitosis1
  • Ubiquitinated. Degradation during prophase is ubiquitin-dependent1
  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_O60447

  • EVI5 Protein expression data from MOPED and PaxDb:    About this image 
    EVI5 Protein Expression
    REFSEQ proteins: NP_005656.4  
    ENSEMBL proteins: 
     ENSP00000359356   ENSP00000440826   ENSP00000445019  

    Human Recombinant Protein Products for EVI5: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    OriGene Protein Over-expression Lysate: EVI5
    OriGene Custom Protein Services for EVI5 
    GenScript Custom Purified and Recombinant Proteins Services for EVI5
    Novus Biologicals EVI5 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for EVI5

    Gene Ontology (GO): 5 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005622intracellular ----
    GO:0005634nucleus IEA--
    GO:0005737cytoplasm IEA--
    GO:0005815microtubule organizing center IEA--
    GO:0005819spindle IEA--

    EVI5 for ontologies           About GeneDecksing



    EVI5 Antibody Products: 
    EMD Millipore Mono- and Polyclonal Antibodies for the study of EVI5
    Browse R&D Systems for Antibodies
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for EVI5 
    GenScript Custom Superior Antibodies Services for EVI5
    Novus Biologicals EVI5 Antibodies
    Abcam antibodies for EVI5 
    Uscn Antibodies for EVI5
    ThermoFisher Antibodies for EVI5

    Assay Products for EVI5: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Immunoassay Development
    Browse OriGene Fluorogenic Cell Assay Kits
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for EVI5
    Browse Enzo Life Sciences for kits & assays
    Uscn ELISAs and CLIAs for EVI5


    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    EVI5 for domains           About GeneDecksing

    1 InterPro domain/family:
     IPR000195 Rab-GTPase-TBC_dom

    Graphical View of Domain Structure for InterPro Entry O60447

    ProtoNet protein and cluster: O60447

    2 Blocks protein families:
    IPB000195 RabGAP/TBC domain
    IPB000515 Binding-protein-dependent transport systems inner membrane component


    UniProtKB/Swiss-Prot: EVI5_HUMAN, O60447
    Similarity: Contains 1 Rab-GAP TBC domain


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: EVI5_HUMAN, O60447
    Function: Functions as a regulator of cell cycle progression by stabilizing the FBXO5 protein and promoting cyclin-A
    accumulation during interphase. May play a role in cytokinesis
    Induction: Down-regulated during mitosis through proteasomal degradation

         Genatlas biochemistry entry for EVI5:
    ecotropic viral integration site 5,neuroblastoma,infant from stage 4S candidate gene,widely expressed,homolog to HRP1
    (TRE-2) and mouse TBC1,fused with TRNG10 to form a chimeric fusion protein in constitutional translocation
    t(1;10)(p22;q21)

         Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005097Rab GTPase activator activity IEA--
    GO:0005515protein binding IPI16439210
         
    EVI5 for ontologies           About GeneDecksing


    Phenotypes:
         2 GenomeRNAi human phenotypes for EVI5:
     Increased S DNA content  Increased number of mitotic ce 

    Animal Models:
       inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for EVI5 

    miRNA
    Products:
        
    OriGene 3'-UTR Clone: EVI5
    Browse MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat EVI5
    8/97 QIAGEN miScript miRNA Assays for microRNAs that regulate EVI5 (see all 97):
    hsa-miR-194* hsa-miR-3607-3p hsa-miR-188-5p hsa-miR-15a hsa-miR-485-3p hsa-miR-128 hsa-miR-30d hsa-miR-502-3p
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for EVI5 (see all 4)
    OriGene shRNA RFP: EVI5
    OriGene siRNA: EVI5
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat EVI5
    Sirion Biotech Custom design and validation of potent shRNA sequences against EVI5 

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for EVI5
    Sirion Biotech Customized adenovirus for overexpression of EVI5 
    Sirion Biotech Customized adenovirus for potent knockdown of EVI5

    Clone
    Products:
         
    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for EVI5 (see all 2)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for EVI5
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector: EVI5 (NM_005665)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for EVI5
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat EVI5 

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for EVI5
    Search LifeMap BioReagents cell lines for EVI5
    Sirion Biotech Customized stable knockdown cell line services for EVI5 
    Sirion Biotech Customized inducible knockdown cell line services for EVI5
    Sirion Biotech Customized stable overexpressing cell line services for EVI5
    Sirion Biotech Customized inducible overexpressing cell line services for EVI5

    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for EVI5


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways  About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Aurora B signaling
    Aurora B signaling1.00


    1 BioSystems Pathway for EVI5 
        Aurora B signaling


    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for EVI5

    STRING Interaction Network Preview (showing 5 interactants - click image to see 7)

    5/39 Interacting proteins for EVI5 (O604471, 3 ENSP000003593564) via UniProtKB, MINT, STRING, and/or I2D (see all 39)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    FBXO5Q9UKT41, 3, ENSP000002297584EBI-852291,EBI-852298 I2D: score=3 STRING: ENSP00000229758
    PLK1P533501, 3, ENSP000003000934EBI-852291,EBI-476768 I2D: score=1 STRING: ENSP00000300093
    AURKBQ96GD43, ENSP000003139504I2D: score=1 STRING: ENSP00000313950
    INCENPQ9NQS73, ENSP000003782954I2D: score=1 STRING: ENSP00000378295
    BIRC5O153923, ENSP000003016334I2D: score=1 STRING: ENSP00000301633
    About this table

    Gene Ontology (GO): 4 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007049cell cycle IEA--
    GO:0007275multicellular organismal development TAS9618176
    GO:0008283cell proliferation TAS9618176
    GO:0051301cell division IEA--

    EVI5 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for EVI5
    Search CenterWatch for drugs/clinical trials and news about EVI5 

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, Sirion Biotech, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for EVI5 gene: 
    NM_005665.4  

    Unigene Cluster for EVI5:

    Ecotropic viral integration site 5
    Hs.594434  [show with all ESTs]
    Unigene Representative Sequence: NM_005665
    9 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000370331(uc001dox.3 uc010otf.2) ENST00000491940 ENST00000492513
    ENST00000468580 ENST00000492613 ENST00000474806 ENST00000466778 ENST00000540033
    ENST00000543509(uc001doy.1)

    miRNA
    Products:
         
    OriGene 3'-UTR Clone: EVI5
    Browse OriGene MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat EVI5
    8/97 QIAGEN miScript miRNA Assays for microRNAs that regulate EVI5 (see all 97):
    hsa-miR-194* hsa-miR-3607-3p hsa-miR-188-5p hsa-miR-15a hsa-miR-485-3p hsa-miR-128 hsa-miR-30d hsa-miR-502-3p
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for EVI5 (see all 4)
    OriGene shRNA RFP: EVI5
    OriGene siRNA: EVI5
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat EVI5
    Sirion Biotech Custom design and validation of potent shRNA sequences against EVI5 
    Clone
    Products:
         
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for EVI5 (see all 2)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for EVI5
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector: EVI5 (NM_005665)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for EVI5
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat EVI5 
    Primer
    Products:
        
    OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for EVI5
    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat EVI5
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat EVI5
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat EVI5

    Additional cDNA sequence: 

    AB209513.1 AB449875.1 AF008915.1 

    11 DOTS entries:

    DT.416560  DT.95324473  DT.95264988  DT.101968109  DT.100714794  DT.40132263  DT.91717004  DT.92009937 
    DT.95339072  DT.121402397  DT.92042891 

    24/110 AceView cDNA sequences (see all 110):

    AA725529 BF060772 BM835541 AA478513 BG943103 AA693846 AA362568 AA772947 
    BF435186 C02379 F05844 AA478512 BX098889 BG259900 AI635805 Z38177 
    CD106262 F05127 AA262153 AA628572 Z42583 F02094 BX093275 BU685559 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    EVI5 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: AAATCAGTTA
    EVI5 Expression
    About this image
    See EVI5 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for EVI5

    SOURCE GeneReport for Unigene cluster: Hs.594434

    UniProtKB/Swiss-Prot: EVI5_HUMAN, O60447
    Tissue specificity: Expressed in various cell lines (at protein level). Expressed in a wide range of tissues including
    brain and adrenal

        SABiosciences Custom PCR Arrays for EVI5
    Primer
    Products:
    OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for EVI5
    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat EVI5
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat EVI5
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat EVI5
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for EVI5

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for EVI5 gene from 8/26 species (see all 26)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    chicken
    (Gallus gallus)
    Aves EVI56
    Uncharacterized protein
    87(a)
    1 ↔ 1
    8(14756146-14805212)
    lizard
    (Anolis carolinensis)
    Reptilia EVI56
    --
    83(a)
    1 ↔ 1
    4(93598863-93662388)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.128982 Xenopus laevis transcribed sequence with moderate similarity more 76.07(n)    BG555915.1 
    zebrafish
    (Danio rerio)
    Actinopterygii evi5b6
    CU855813.16
    --
    76(a)
    43(a)
    1 ↔ many
    1 ↔ many
    6(28725707-28800269)
    2(10501363-10526503)
    fruit fly
    (Drosophila melanogaster)
    Insecta CG117273   -- 30(a)     --
    worm
    (Caenorhabditis elegans)
    Secernentea T24D11.13   -- 50(a)   X(16436681-16438275)   --
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons AT3G024601 RabGAP/TBC domain-containing protein 49.78(n)
    39.03(a)
      821261  NM_111113.3  NP_566172.1 
    rice
    (Oryza sativa)
    Liliopsida Os08g04126001 hypothetical protein 51.06(n)
    39.02(a)
      4345560  NM_001068330.1  NP_001061795.1 


    ENSEMBL Gene Tree for EVI5 (if available)
    TreeFam Gene Tree for EVI5 (if available) 

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for EVI5 gene
    RABGAP1L2  TBC1D122  TBC1D42  TBC1D142  TBC1D12  EVI5L2  RABGAP12  
    8 SIMAP similar genes for EVI5 using alignment to 3 protein entries:     EVI5_HUMAN (see all proteins):
    EVI5L    RABGAP1L    TBC1D1    TBC1D10A    RABGAP1    FLJ00288
    TBC1D10C    SGSM3

    EVI5 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/5280 NCBI SNPs in EVI5 are shown (see all 5280    About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1413703071,2
    --92973831(+) ATGTAA/GTCCCT 1 -- ds50010--------
    rs717726901,2
    C--92973888(+) CAACC-/TTTTTT 1 -- ds50010--------
    rs1815220591,2
    --92973934(+) CCCAGA/GCTGGA 1 -- ds50010--------
    rs1876126171,2
    --92973981(+) CCTCCC/TGGGTT 1 -- ds50010--------
    rs1918902361,2
    --92973984(+) CCCGGA/GTTCAA 1 -- ds50010--------
    rs1830290661,2
    --92973991(+) TCAAGC/TGATTC 1 -- ds50010--------
    rs111646601,2
    --92974050(+) cacctA/Ggctaa 1 -- ds50010--------
    rs1867624651,2
    --92974243(+) TGAAGC/GAAACA 1 -- ds50010--------
    rs1380886701,2
    --92974403(+) ATTCTA/GTCATC 1 -- ut310--------
    rs1896903801,2
    --92974460(+) TGTAAA/GAACTT 1 -- ut310--------

    HapMap Linkage Disequilibrium report for EVI5 (92974253 - 93224253 bp, first 250kb of EVI5)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 2 variations for EVI5
         1 CNV: 43784
         1 Indel: 97441
    Human Gene Mutation Database (HGMD): EVI5

    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing EVI5
    DNA2.0 Custom Variant and Variant Library Synthesis for EVI5

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    EVI5 for disorders           About GeneDecksing

    OMIM gene information: 602942    OMIM disorders: --

    UniProtKB/Swiss-Prot: EVI5_HUMAN, O60447
  • Note=A chromosomal aberration involving EVI5 is found is a patient with stage 4S neuroblastoma. Translocation
  • t(1;10)(p22;q21) that forms a EVI5-TRNG10 fusion protein. TRNG10 is a probable structural transcript which is normally
    not translated

    2 diseases for EVI5:    About MalaCards
    neuroblastoma    multiple sclerosis

    Human Genome Epidemiology (HuGE) Navigator: EVI5 (7 documents)

    Export disorders for EVI5 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for EVI5 gene, integrated from 9 sources (see all 21):
    (articles sorted by number of sources associating them with EVI5)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. NB4S, a member of the TBC1 domain family of genes, is truncated as a result of a constitutional t(1;10)(p22;q21) chromosome translocation in a patient with stage 4S neuroblastoma. (PubMed id 9618176)1, 2, 3 Roberts T.... Cowell J.K. (1998)
    2. EVI5 protein associates with the INCENP-aurora B kinase-survivin chromosomal passenger complex and is involved in the completion of cytokinesis. (PubMed id 16764853)1, 2, 9 Faitar S.L.... Cowell J.K. (2006)
    3. EVI5 is a novel centrosomal protein that binds to alpha- and gamma- tubulin. (PubMed id 16033705)1, 2, 9 Faitar S.L.... Cowell J.K. (2005)
    4. The evi5 oncogene regulates cyclin accumulation by stabilizing the anaphase-promoting complex inhibitor emi1. (PubMed id 16439210)1, 2 Eldridge A.G.... Jackson P.K. (2006)
    5. The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)1, 2 Gregory S.G.... Bentley D.R. (2006)
    6. The EVI5 TBC domain provides the GTPase-activating protein motif for RAB11. (PubMed id 17099728)1, 9 Dabbeekeh J.T....Cowell J.K. (2007)
    7. Genetic risk and a primary role for cell-mediated immu ne mechanisms in multiple sclerosis. (PubMed id 21833088)1  ....Compston A. (2011)
    8. Biological, clinical and population relevance of 95 l oci for blood lipids. (PubMed id 20686565)1 Teslovich T.M....Kathiresan S. (2010)
    9. Tag-SNP analysis of the GFI1-EVI5-RPL5-FAM69 risk loc us for multiple sclerosis. (PubMed id 20087403)1 Alcina A....Matesanz F. (2010)
    10. Stem cell exhaustion due to Runx1 deficiency is preve nted by Evi5 activation in leukemogenesis. (PubMed id 20008790)1 Jacob B....Ito Y. (2010)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 7813 HGNC: 3501 AceView: EVI5 Ensembl:ENSG00000067208 euGenes: HUgn7813
    ECgene: EVI5 H-InvDB: EVI5

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for EVI5 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for EVI5 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for EVI5 gene:
    Search GeneIP for patents involving EVI5

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory)
    About This Section

     Browse Purified and Recombinant Proteins at EMD Millipore
     Browse for Gene Knock-down Tools from EMD Millipore
     EMD Millipore Mono- and Polyclonal Antibodies for the study of EVI5
     Browse Small Molecules at EMD Millipore
     Browse Kits and Assays available from EMD Millipore
     Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
     
     EMD Millipore Custom Antibody & Bulk Services
     EMD Millipore Preclinical / Clinical Development Services
     EMD Millipore Immunoassay Services
     EMD Millipore Target Screening & Profiling Services

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
     Browse ELISpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Multiplex/Array Assay Kits/Reagents  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Phosphatase Activity Assays/Reagents   Browse Recombinant/Natural Proteins  
     Browse OriGene Antibodies   OriGene shRNA RFP for EVI5  
     OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for EVI5   OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for EVI5  
     OriGene Protein Over-expression Lysate for EVI5   Browse OriGene Fluorogenic Cell Assay Kits  
     OriGene siRNA for EVI5   OriGene 3'-UTR Clone for EVI5  
     OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for EVI5   OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for EVI5  
     Browse OriGene GFP tagged cDNA clones in CMV expression vector   Browse OriGene MicroRNA Expression Plasmids  
     Browse OriGene basic RS shRNAs   Browse OriGene validated miRNA SYBR primer pairs  
     Browse OriGene full length recombinant human proteins expressed in human HEK293 cells   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for EVI5   OriGene Custom Protein Services for EVI5  
     OriGene Custom Immunoassay Development  

     
     
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat EVI5
     QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing EVI5
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat EVI5
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat EVI5
     QIAGEN QuantiFast Probe-based Assays in human, mouse, rat EVI5
     QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat EVI5
     GenScript Custom Purified and Recombinant Proteins Services for EVI5 GenScript cDNA clones with any tag delivered in your preferred vector for EVI5
     GenScript Custom Assay Services for EVI5 GenScript Custom Superior Antibodies Services for EVI5
     GenScript Custom overexpressing Cell Line Services for EVI5 CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Search for Antibodies & Assays

     Regulatory tfbs in EVI5 promoter
     Search Chromatin IP Primers for EVI5
     RT2 qPCR Primer Assay in human, mouse, rat EVI5
     GNC Network for EVI5
     SABiosciences Custom PCR Arrays for EVI5
     Search Tocris compounds for EVI5
     Browse Sino Biological Proteins and Antibodies
     Browse Sino Biological cDNA Clones
     Antibodies/Proteins Production Services
     Rabbit Monoclonal Antibody Platform
     Bulk Purchasing
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     EVI5 antibodies
     EVI5 lysates
     Antibodies for EVI5
     See all of Abcam's Antibodies, Kits and Proteins for EVI5
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins




     EVI5 Proteins, Antibodies, CLIAs, and ELISAs
     Search LifeMap BioReagents cell lines for EVI5
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for EVI5
     Browse SwitchGear 3'UTR luciferase reporter plasmids for EVI5
     SwitchGear Promoter luciferase reporter plasmids for EVI5
     ThermoFisher Antibodies for EVI5
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat EVI5
     inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for EVI5
    Sirion Biotech Customized:
     stable knockdown cell line services for EVI5
     inducible knockdown cell line services for EVI5
     design and validation of potent shRNA sequences against EVI5
     adenovirus for potent knockdown of EVI5
     adenovirus for overexpression of EVI5
     stable overexpressing cell line services for EVI5
     inducible overexpressing cell line services for EVI5
           
    GeneCards Homepage - Last full update: 18 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013 , 13 May 2013

    View Random Gene

    Category
    VWF
    (GIFTS: 73)
    von Willebrand factor
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      EVI5 gene at Home site.
    hostname: 356980-web2.xennexinc.com index build: 106 solr: 1.4