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EVI5 Gene

protein-coding   GIFtS: 62
GCID: GC01M092974

Ecotropic Viral Integration Site 5

Microbiology & Infectious Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Ecotropic Viral Integration Site 51 2     Neuroblastoma Stage 4S Gene1
NB4S2 3 5     DJ846D11.1 (Ecotropic Viral Integration Site 5)2
Neuroblastoma Stage 4S Gene Protein2 3     Ecotropic Viral Integration Site 5 Protein Homolog2
EVI-52 3     

External Ids:    HGNC: 35011   Entrez Gene: 78132   Ensembl: ENSG000000672087   OMIM: 6029425   UniProtKB: O604473   

Export aliases for EVI5 gene to outside databases

Previous GC identifers: GC01M093448 GC01M092183 GC01M092311 GC01M092446 GC01M092691 GC01M092746 GC01M091095


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for EVI5 Gene:
EVI5 (ecotropic viral integration site 5) is a protein-coding gene. Diseases associated with EVI5 include neuroblastoma, and multiple sclerosis. GO annotations related to this gene include Rab GTPase activator activity. An important paralog of this gene is TBC1D12.

UniProtKB/Swiss-Prot: EVI5_HUMAN, O60447
Function: Functions as a regulator of cell cycle progression by stabilizing the FBXO5 protein and promoting
cyclin-A accumulation during interphase. May play a role in cytokinesis

Gene Wiki entry for EVI5 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000001.11  NT_032977.10  NC_018912.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the EVI5 gene promoter:
         c-Fos   p53   HNF-1A   C/EBPalpha   CHOP-10   MEF-2A   HNF-1   c-Jun   aMEF-2   RSRFC4   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): EVI5 promoter sequence
   Search Chromatin IP Primers for EVI5

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat EVI5


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1p22.1   Ensembl cytogenetic band:  1p22.1   HGNC cytogenetic band: 1p22

EVI5 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
EVI5 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01M092974:  view genomic region     (about GC identifiers)

Start:
92,974,253 bp from pter      End:
93,257,961 bp from pter
Size:
283,709 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: EVI5_HUMAN, O60447 (See protein sequence)
Recommended Name: Ecotropic viral integration site 5 protein homolog  
Size: 810 amino acids; 92949 Da
Subunit: Dimeric and monomeric. Interacts with alpha- and gamma-tubulin. Interacts with FBXO5. Interacts with the
chromosome passenger complex (CPC) which is at least composed of AURKB/aurora-B, BIRC5/survivin, CDCA8/borealin
and INCENP
Miscellaneous: Depletion of EVI5 by RNAi causes cell cycle arrest and mitotic abnormalities
Secondary accessions: A6NKX8 Q9H1Y9

Explore the universe of human proteins at neXtProt for EVI5: NX_O60447

Explore proteomics data for EVI5 at MOPED

Post-translational modifications: 

  • Probably phosphorylated by PLK1; may be required for degradation during mitosis1
  • Ubiquitinated. Degradation during prophase is ubiquitin-dependent1
  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See EVI5 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_005656.4  
    ENSEMBL proteins: 
     ENSP00000359356   ENSP00000440826   ENSP00000445019  

    EVI5 Human Recombinant Protein Products:

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    Novus Biologicals EVI5 Lysate
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    EVI5 Antibody Products:

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    EVI5 Assay Products:

    Browse Kits and Assays available from EMD Millipore
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    Cloud-Clone Corp. ELISAs for EVI5
    Cloud-Clone Corp. CLIAs for EVI5


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    1 InterPro protein domain:
     IPR000195 Rab-GTPase-TBC_dom

    Graphical View of Domain Structure for InterPro Entry O60447

    ProtoNet protein and cluster: O60447

    2 Blocks protein domains:
    IPB000195 RabGAP/TBC domain
    IPB000515 Binding-protein-dependent transport systems inner membrane component


    UniProtKB/Swiss-Prot: EVI5_HUMAN, O60447
    Similarity: Contains 1 Rab-GAP TBC domain


    EVI5 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: EVI5_HUMAN, O60447
    Function: Functions as a regulator of cell cycle progression by stabilizing the FBXO5 protein and promoting
    cyclin-A accumulation during interphase. May play a role in cytokinesis
    Induction: Down-regulated during mitosis through proteasomal degradation

         Genatlas biochemistry entry for EVI5:
    ecotropic viral integration site 5,neuroblastoma,infant from stage 4S candidate gene,widely expressed,homolog to
    HRP1 (TRE-2) and mouse TBC1,fused with TRNG10 to form a chimeric fusion protein in constitutional translocation
    t(1;10)(p22;q21)

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005097Rab GTPase activator activity IEA--
    GO:0005515protein binding IPI16439210
         
    EVI5 for ontologies           About GeneDecksing


    Phenotypes:
         2 GenomeRNAi human phenotypes for EVI5:
     Increased S DNA content  Increased number of mitotic ce 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for EVI5
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for EVI5

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for EVI5
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for EVI5

    miRNA
    Products:
        
    miRTarBase miRNAs that target EVI5:
    hsa-mir-124-3p (MIRT022914), hsa-mir-96-5p (MIRT027925), hsa-mir-182-5p (MIRT047210)

    Block miRNA regulation of human, mouse, rat EVI5 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate EVI5 (see all 97):
    hsa-miR-194* hsa-miR-3607-3p hsa-miR-188-5p hsa-miR-15a hsa-miR-485-3p hsa-miR-128 hsa-miR-30d hsa-miR-502-3p
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat EVI5

    Gene Editing
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    GenScript: all cDNA clones in your preferred vector: EVI5 (NM_005665)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for EVI5
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat EVI5

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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for EVI5


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    EVI5_HUMAN, O60447: Nucleus. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm,
    cytoskeleton, spindle. Note=Associates with the mitotic spindle through anaphase and remains within the midzone
    and midbody until completion of cytokinesis
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytoskeleton5
    nucleus5
    cytosol2
    endosome1

    Gene Ontology (GO): Selected cellular component terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IEA--
    GO:0005737cytoplasm ----
    GO:0005794Golgi apparatus IDA--
    GO:0005815microtubule organizing center IEA--
    GO:0005819spindle IEA--

    EVI5 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for EVI5 About    
    See pathways by source

    SuperPathContained pathways About
    1Aurora B signaling
    Aurora B signaling


    1 BioSystems Pathway for EVI5
        Aurora B signaling


        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for EVI5
    Interactions:

        GeneGlobe Interaction Network for EVI5

    STRING Interaction Network Preview (showing 5 interactants - click image to see 12)

    Selected Interacting proteins for EVI5 (O604471, 3 ENSP000003593564) via UniProtKB, MINT, STRING, and/or I2D (see all 49)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ENSG00000172850Q9Y3333I2D: score=4 
    ENSG00000224979Q9Y3333I2D: score=4 
    ENSG00000225998Q9Y3333I2D: score=4 
    ENSG00000231502Q9Y3333I2D: score=4 
    ENSG00000236826Q9Y3333I2D: score=4 
    About this table

    Gene Ontology (GO): 5 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007049cell cycle IEA--
    GO:0007275multicellular organismal development TAS9618176
    GO:0008283cell proliferation TAS9618176
    GO:0032313regulation of Rab GTPase activity ----
    GO:0051301cell division IEA--

    EVI5 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for EVI5



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for EVI5 gene: 
    NM_005665.4  

    Unigene Cluster for EVI5:

    Ecotropic viral integration site 5
    Hs.594434  [show with all ESTs]
    Unigene Representative Sequence: NM_005665
    9 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000370331(uc001dox.3 uc010otf.2) ENST00000491940 ENST00000492513
    ENST00000468580 ENST00000492613 ENST00000474806 ENST00000466778 ENST00000540033
    ENST00000543509(uc001doy.1)
    Congresses - knowledge worth sharing:
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat EVI5 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate EVI5 (see all 97):
    hsa-miR-194* hsa-miR-3607-3p hsa-miR-188-5p hsa-miR-15a hsa-miR-485-3p hsa-miR-128 hsa-miR-30d hsa-miR-502-3p
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
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    OriGene RNAi products in human, mouse, rat for EVI5
    Predesigned siRNA for gene silencing in human, mouse, rat EVI5
    Clone
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    OriGene clones in human, mouse for EVI5 (see all 6)
    OriGene ORF clones in mouse, rat for EVI5
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: EVI5 (NM_005665)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for EVI5
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat EVI5
    Primer
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    OriGene qSTAR qPCR primer pairs in human, mouse for EVI5
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat EVI5
      QuantiTect SYBR Green Assays in human, mouse, rat EVI5
      QuantiFast Probe-based Assays in human, mouse, rat EVI5

    Additional mRNA sequence: 

    AB209513.1 AB449875.1 AF008915.1 

    11 DOTS entries:

    DT.416560  DT.95324473  DT.95264988  DT.101968109  DT.100714794  DT.40132263  DT.91717004  DT.92009937 
    DT.95339072  DT.121402397  DT.92042891 

    Selected AceView cDNA sequences (see all 110):

    AA478513 BG943103 F05127 BM835541 AA725529 BG259900 F05844 C02379 
    Z42583 AA478512 CD106262 Z38177 AA362568 AA693846 AA772947 AA628572 
    AA262153 BF060772 BF435186 BX098889 AI635805 AI694123 AW297422 AI887934 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    EVI5 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AAATCAGTTA
    EVI5 Expression
    About this image

    EVI5 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    EVI5 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.594434

    UniProtKB/Swiss-Prot: EVI5_HUMAN, O60447
    Tissue specificity: Expressed in various cell lines (at protein level). Expressed in a wide range of tissues
    including brain and adrenal

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for EVI5

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for EVI5 gene from Selected species (see all 19)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Evi51 , 5 ecotropic viral integration site 51, 5 89.2(n)1
    91.72(a)1
      5 (52.23 cM)5
    140201  NM_007964.21  NP_031990.21 
     1077447955 
    chicken
    (Gallus gallus)
    Aves EVI51 ecotropic viral integration site 5 72.36(n)
    70.29(a)
      424500  XM_422340.4  XP_422340.3 
    lizard
    (Anolis carolinensis)
    Reptilia EVI56
    ecotropic viral integration site 5
    79(a)
    1 ↔ 1
    4(93563601-93663808)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.128982 Xenopus laevis transcribed sequence with moderate similarity more 76.07(n)    BG555915.1 
    zebrafish
    (Danio rerio)
    Actinopterygii evi5b1 ecotropic viral integration site 5b 72.21(n)
    81(a)
      553306  XM_003198798.2  XP_003198846.2 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG117273
    Evi51
    Evi51 30(a)3
    49.31(n)1
    48.62(a)1
      320881  NM_167285.41  NP_727526.21 
    worm
    (Caenorhabditis elegans)
    Secernentea T24D11.13
    tbc-41
    tbc-41 50(a)3
    55.04(n)1
    51.74(a)1
      X(16436681-16438275)3
    35658051  NM_078266.31  NP_510667.21 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes GYL1(YMR192W)4 Putative GTPase activating protein (GAP) with a role more   --   13(647118-649280) 855230  NP_013917.1 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons AT3G024601 AT3G02460 52.04(n)
    41.01(a)
      821261  NM_111113.3  NP_566172.1 
    rice
    (Oryza sativa)
    Liliopsida Os08g04126001 Os08g0412600 50.89(n)
    39.02(a)
      4345560  NM_001068330.1  NP_001061795.1 


    ENSEMBL Gene Tree for EVI5 (if available)
    TreeFam Gene Tree for EVI5 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for EVI5 gene
    TBC1D122  TBC1D42  TBC1D142  RABGAP1L2  TBC1D12  EVI5L2  RABGAP12  
    8 SIMAP similar genes for EVI5 using alignment to 3 protein entries:     EVI5_HUMAN (see all proteins):
    EVI5L    RABGAP1L    TBC1D1    TBC1D10A    RABGAP1    FLJ00288
    TBC1D10C    SGSM3

    EVI5 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for EVI5 (see all 6058)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1413703071,2
    --92973831(+) ATGTAA/GTCCCT 1 -- ds50010--------
    rs717726901,2
    C--92973888(+) CAACC-/TTTTTT 1 -- ds50010--------
    rs1815220591,2
    --92973934(+) CCCAGA/GCTGGA 1 -- ds50010--------
    rs1876126171,2
    --92973981(+) CCTCCC/TGGGTT 1 -- ds50010--------
    rs1918902361,2
    --92973984(+) CCCGGA/GTTCAA 1 -- ds50010--------
    rs1830290661,2
    --92973991(+) TCAAGC/TGATTC 1 -- ds50010--------
    rs111646601,2
    C--92974050(+) cacctA/Ggctaa 1 -- ds50010--------
    rs1138225121,2
    C--92974092(+) CCATGC/TTGGCC 1 -- ds50011Minor allele frequency- T:0.50CSA 2
    rs1867624651,2
    --92974243(+) TGAAGC/GAAACA 1 -- ds50010--------
    rs1380886701,2
    --92974403(+) ATTCTA/GTCATC 1 -- ut310--------

    HapMap Linkage Disequilibrium report for EVI5 (92974253 - 93224253 bp, first 250kb of EVI5)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for EVI5 (see all 14):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2669727CNV Deletion23128226
    esv2714684CNV Deletion23290073
    esv2656994CNV Deletion23128226
    esv1938423CNV Deletion18987734
    esv2674141CNV Deletion23128226
    esv1233172CNV Insertion17803354
    esv1001160CNV Insertion20482838
    esv269509CNV Insertion20981092
    esv2533438CNV Insertion19546169
    nsv159896CNV Insertion16902084

    Human Gene Mutation Database (HGMD): EVI5
    Site Specific Mutation Identification with PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 602942    OMIM disorders: --

    UniProtKB/Swiss-Prot: EVI5_HUMAN, O60447
  • Note=A chromosomal aberration involving EVI5 is found is a patient with stage 4S neuroblastoma.
    Translocation t(1;10)(p22;q21) that forms a EVI5-TRNG10 fusion protein. TRNG10 is a probable structural
    transcript which is normally not translated

  • 4 diseases for EVI5:    
    About MalaCards
    neuroblastoma    multiple sclerosis    multiple myeloma    myeloma


    EVI5 for disorders           About GeneDecksing

    Genetic Association Database (GAD): EVI5
    Human Genome Epidemiology (HuGE) Navigator: EVI5 (7 documents)

    Export disorders for EVI5 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for EVI5 gene, integrated from 10 sources (see all 25):
    (articles sorted by number of sources associating them with EVI5)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. NB4S, a member of the TBC1 domain family of genes, is truncated as a result of a constitutional t(1;10)(p22;q21) chromosome translocation in a patient with stage 4S neuroblastoma. (PubMed id 9618176)1, 2, 3 Roberts T.... Cowell J.K. (Hum. Mol. Genet. 1998)
    2. EVI5 protein associates with the INCENP-aurora B kinase-survivin chromosomal passenger complex and is involved in the completion of cytokinesis. (PubMed id 16764853)1, 2, 9 Faitar S.L.... Cowell J.K. (Exp. Cell Res. 2006)
    3. EVI5 is a novel centrosomal protein that binds to alpha- and gamma- tubulin. (PubMed id 16033705)1, 2, 9 Faitar S.L.... Cowell J.K. (Genomics 2005)
    4. Biological, clinical and population relevance of 95 loci for blood lipids. (PubMed id 20686565)1, 4 Teslovich T.M....Kathiresan S. (Nature 2010)
    5. Multiple sclerosis susceptibility alleles in African Americans. (PubMed id 19865102)1, 4 Johnson B.A....Oksenberg J.R. (Genes Immun. 2010)
    6. Tag-SNP analysis of the GFI1-EVI5-RPL5-FAM69 risk locus for multiple sclerosis. (PubMed id 20087403)1, 4 Alcina A....Matesanz F. (Eur. J. Hum. Genet. 2010)
    7. Replication of CD58 and CLEC16A as genome-wide significant risk genes for multiple sclerosis. (PubMed id 19834503)1, 4 Hoppenbrouwers I.A....Hintzen R.Q. (J. Hum. Genet. 2009)
    8. Genome-wide association study identifies new multiple sclerosis susceptibility loci on chromosomes 12 and 20. (PubMed id 19525955)1, 4 (Nat. Genet. 2009)
    9. Risk alleles for multiple sclerosis in multiplex families. (PubMed id 19506219)1, 4 D'Netto M.J....Ebers G.C. (Neurology 2009)
    10. EVI5 is a risk gene for multiple sclerosis. (PubMed id 18401352)1, 4 Hoppenbrouwers I.A....Hintzen R.Q. (Genes Immun. 2008)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 7813 HGNC: 3501 AceView: EVI5 Ensembl:ENSG00000067208 euGenes: HUgn7813
    ECgene: EVI5 H-InvDB: EVI5

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for EVI5 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for EVI5 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for EVI5 gene:
    Search GeneIP for patents involving EVI5

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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