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Aliases for EVI5 Gene

Aliases for EVI5 Gene

  • Ecotropic Viral Integration Site 5 2 3 5
  • Neuroblastoma Stage 4S Gene Protein 3 4
  • EVI-5 3 4
  • NB4S 3 4
  • DJ846D11.1 (Ecotropic Viral Integration Site 5) 3
  • Neuroblastoma Stage 4S Gene 2

External Ids for EVI5 Gene

Previous GeneCards Identifiers for EVI5 Gene

  • GC01M093448
  • GC01M092183
  • GC01M092311
  • GC01M092691
  • GC01M092746
  • GC01M092974
  • GC01M091095

Summaries for EVI5 Gene

GeneCards Summary for EVI5 Gene

EVI5 (Ecotropic Viral Integration Site 5) is a Protein Coding gene. Diseases associated with EVI5 include Neuroblastoma and Interleukin-7 Receptor Alpha Deficiency. Among its related pathways are Aurora B signaling. GO annotations related to this gene include GTPase activator activity and Rab GTPase binding. An important paralog of this gene is EVI5L.

UniProtKB/Swiss-Prot for EVI5 Gene

  • Functions as a regulator of cell cycle progression by stabilizing the FBXO5 protein and promoting cyclin-A accumulation during interphase. May play a role in cytokinesis.

Gene Wiki entry for EVI5 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for EVI5 Gene

Genomics for EVI5 Gene

Regulatory Elements for EVI5 Gene

Enhancers for EVI5 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around EVI5 on UCSC Golden Path with GeneCards custom track

Promoters for EVI5 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around EVI5 on UCSC Golden Path with GeneCards custom track

Genomic Location for EVI5 Gene

Chromosome:
1
Start:
92,508,696 bp from pter
End:
92,792,404 bp from pter
Size:
283,709 bases
Orientation:
Minus strand

Genomic View for EVI5 Gene

Genes around EVI5 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
EVI5 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for EVI5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for EVI5 Gene

Proteins for EVI5 Gene

  • Protein details for EVI5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O60447-EVI5_HUMAN
    Recommended name:
    Ecotropic viral integration site 5 protein homolog
    Protein Accession:
    O60447
    Secondary Accessions:
    • A6NKX8
    • B9A6J0
    • Q9H1Y9

    Protein attributes for EVI5 Gene

    Size:
    810 amino acids
    Molecular mass:
    92949 Da
    Quaternary structure:
    • Dimeric and monomeric. Interacts with alpha- and gamma-tubulin. Interacts with FBXO5. Interacts with the chromosome passenger complex (CPC) which is at least composed of AURKB/aurora-B, BIRC5/survivin, CDCA8/borealin and INCENP.
    Miscellaneous:
    • Depletion of EVI5 by RNAi causes cell cycle arrest and mitotic abnormalities.

    Alternative splice isoforms for EVI5 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for EVI5 Gene

Proteomics data for EVI5 Gene at MOPED

Post-translational modifications for EVI5 Gene

  • Probably phosphorylated by PLK1; may be required for degradation during mitosis.
  • Ubiquitinated. Degradation during prophase is ubiquitin-dependent.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for EVI5 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for EVI5 Gene

Domains & Families for EVI5 Gene

Suggested Antigen Peptide Sequences for EVI5 Gene

Graphical View of Domain Structure for InterPro Entry

O60447

UniProtKB/Swiss-Prot:

EVI5_HUMAN :
  • Contains 1 Rab-GAP TBC domain.
Domain:
  • Contains 1 Rab-GAP TBC domain.
genes like me logo Genes that share domains with EVI5: view

No data available for Gene Families for EVI5 Gene

Function for EVI5 Gene

Molecular function for EVI5 Gene

GENATLAS Biochemistry:
ecotropic viral integration site 5,neuroblastoma,infant from stage 4S candidate gene,widely expressed,homolog to HRP1 (TRE-2) and mouse TBC1,fused with TRNG10 to form a chimeric fusion protein in constitutional translocation t(1;10)(p22;q21)
UniProtKB/Swiss-Prot Function:
Functions as a regulator of cell cycle progression by stabilizing the FBXO5 protein and promoting cyclin-A accumulation during interphase. May play a role in cytokinesis.
UniProtKB/Swiss-Prot Induction:
Down-regulated during mitosis through proteasomal degradation.

Gene Ontology (GO) - Molecular Function for EVI5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005096 GTPase activator activity IDA 17562788
genes like me logo Genes that share ontologies with EVI5: view
genes like me logo Genes that share phenotypes with EVI5: view

Animal Models for EVI5 Gene

MGI Knock Outs for EVI5:
  • Evi5 tm1a(KOMP)Wtsi

Animal Model Products

miRNA for EVI5 Gene

miRTarBase miRNAs that target EVI5

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for EVI5 Gene

Localization for EVI5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for EVI5 Gene

Nucleus. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, cytoskeleton, spindle. Note=Associates with the mitotic spindle through anaphase and remains within the midzone and midbody until completion of cytokinesis.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for EVI5 Gene COMPARTMENTS Subcellular localization image for EVI5 gene
Compartment Confidence
cytoskeleton 5
cytosol 5
golgi apparatus 5
nucleus 5
endosome 1

Gene Ontology (GO) - Cellular Components for EVI5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005819 spindle IEA --
GO:0012505 endomembrane system IBA --
genes like me logo Genes that share ontologies with EVI5: view

Pathways & Interactions for EVI5 Gene

SuperPathways for EVI5 Gene

Superpath Contained pathways
1 Aurora B signaling
genes like me logo Genes that share pathways with EVI5: view

Pathways by source for EVI5 Gene

1 BioSystems pathway for EVI5 Gene

SIGNOR curated interactions for EVI5 Gene

Inactivates:

Gene Ontology (GO) - Biological Process for EVI5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006886 intracellular protein transport IBA --
GO:0007275 multicellular organism development TAS 9618176
GO:0031338 regulation of vesicle fusion IBA --
GO:0042147 retrograde transport, endosome to Golgi IMP 17562788
GO:0043547 positive regulation of GTPase activity IEA --
genes like me logo Genes that share ontologies with EVI5: view

Drugs & Compounds for EVI5 Gene

No Compound Related Data Available

Transcripts for EVI5 Gene

Unigene Clusters for EVI5 Gene

Ecotropic viral integration site 5:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for EVI5 Gene

No ASD Table

Relevant External Links for EVI5 Gene

GeneLoc Exon Structure for
EVI5
ECgene alternative splicing isoforms for
EVI5

Expression for EVI5 Gene

mRNA expression in normal human tissues for EVI5 Gene

Protein differential expression in normal tissues from HIPED for EVI5 Gene

This gene is overexpressed in Bone marrow mesenchymal stem cell (50.1) and Plasma (6.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for EVI5 Gene



SOURCE GeneReport for Unigene cluster for EVI5 Gene Hs.594434

mRNA Expression by UniProt/SwissProt for EVI5 Gene

O60447-EVI5_HUMAN
Tissue specificity: Expressed in various cell lines (at protein level). Expressed in a wide range of tissues including brain and adrenal.
genes like me logo Genes that share expression patterns with EVI5: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Protein tissue co-expression partners for EVI5 Gene

Orthologs for EVI5 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for EVI5 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia EVI5 35
  • 91.79 (n)
  • 94.07 (a)
EVI5 36
  • 94 (a)
OneToOne
dog
(Canis familiaris)
Mammalia EVI5 35
  • 91.81 (n)
  • 93.64 (a)
EVI5 36
  • 97 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Evi5 35
  • 89.2 (n)
  • 91.72 (a)
Evi5 16
Evi5 36
  • 92 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia EVI5 35
  • 99.71 (n)
  • 99.63 (a)
EVI5 36
  • 98 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Evi5 35
  • 87.14 (n)
  • 90.73 (a)
oppossum
(Monodelphis domestica)
Mammalia EVI5 36
  • 83 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia EVI5 36
  • 94 (a)
OneToOne
chicken
(Gallus gallus)
Aves EVI5 35
  • 72.36 (n)
  • 70.29 (a)
EVI5 36
  • 87 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia EVI5 36
  • 79 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia evi5 35
  • 65.86 (n)
  • 65.19 (a)
Str.3031 35
African clawed frog
(Xenopus laevis)
Amphibia Xl.12898 35
zebrafish
(Danio rerio)
Actinopterygii evi5b 35
  • 72.21 (n)
  • 81 (a)
evi5b 36
  • 76 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG11727 37
  • 30 (a)
Evi5 35
  • 49.31 (n)
  • 48.62 (a)
CG11727 36
  • 40 (a)
OneToMany
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP002354 35
  • 51.49 (n)
  • 51.84 (a)
worm
(Caenorhabditis elegans)
Secernentea T24D11.1 37
  • 50 (a)
tbc-4 35
  • 55.04 (n)
  • 51.74 (a)
eat-17 36
  • 34 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes GYL1 36
  • 16 (a)
ManyToMany
GYP5 36
  • 18 (a)
ManyToMany
GYL1 38
thale cress
(Arabidopsis thaliana)
eudicotyledons AT3G02460 35
  • 52.04 (n)
  • 41.01 (a)
rice
(Oryza sativa)
Liliopsida Os08g0412600 35
  • 50.89 (n)
  • 39.02 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.3125 36
  • 45 (a)
OneToMany
Species with no ortholog for EVI5:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for EVI5 Gene

ENSEMBL:
Gene Tree for EVI5 (if available)
TreeFam:
Gene Tree for EVI5 (if available)

Paralogs for EVI5 Gene

Paralogs for EVI5 Gene

(8) SIMAP similar genes for EVI5 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with EVI5: view

Variants for EVI5 Gene

Sequence variations from dbSNP and Humsavar for EVI5 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs2391199 - 92,695,345(-) TACCA(A/G)TTGCA reference, missense
rs11808092 - 92,607,671(+) TTCTC(A/C)TGTAG intron-variant, reference, missense
rs1064580 - 92,736,434(-) AGACG(A/T)CTTAG reference, missense
rs722356 -- 92,516,848(-) TCTGC(C/T)TGCTT intron-variant
rs723909 -- 92,708,613(+) cttag(G/T)tatat intron-variant

Structural Variations from Database of Genomic Variants (DGV) for EVI5 Gene

Variant ID Type Subtype PubMed ID
esv2714684 CNV Deletion 23290073
nsv523354 CNV Gain 19592680
nsv830603 CNV Loss 17160897
esv2533438 CNV Insertion 19546169
esv269509 CNV Insertion 20981092
esv274271 CNV Insertion 20981092
esv1001160 CNV Insertion 20482838
esv1233172 CNV Insertion 17803354
nsv159896 CNV Insertion 16902084
esv2656994 CNV Deletion 23128226
esv2669727 CNV Deletion 23128226
nsv871263 CNV Loss 21882294
esv1938423 CNV Deletion 18987734
esv2674141 CNV Deletion 23128226

Variation tolerance for EVI5 Gene

Residual Variation Intolerance Score: 86.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 9.27; 88.16% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for EVI5 Gene

Human Gene Mutation Database (HGMD)
EVI5

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for EVI5 Gene

Disorders for EVI5 Gene

MalaCards: The human disease database

(2) MalaCards diseases for EVI5 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
neuroblastoma
  • neuroblastoma 1
interleukin-7 receptor alpha deficiency
  • il-7r
- elite association - COSMIC cancer census association via MalaCards
Search EVI5 in MalaCards View complete list of genes associated with diseases

UniProtKB/Swiss-Prot

EVI5_HUMAN
  • Note=A chromosomal aberration involving EVI5 is found is a patient with stage 4S neuroblastoma. Translocation t(1;10)(p22;q21) that forms a EVI5-TRNG10 fusion protein. TRNG10 is a probable structural transcript which is normally not translated. {ECO:0000269 PubMed:9618176}.

Relevant External Links for EVI5

Genetic Association Database (GAD)
EVI5
Human Genome Epidemiology (HuGE) Navigator
EVI5
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
EVI5
genes like me logo Genes that share disorders with EVI5: view

No data available for Genatlas for EVI5 Gene

Publications for EVI5 Gene

  1. NB4S, a member of the TBC1 domain family of genes, is truncated as a result of a constitutional t(1;10)(p22;q21) chromosome translocation in a patient with stage 4S neuroblastoma. (PMID: 9618176) Roberts T. … Cowell J.K. (Hum. Mol. Genet. 1998) 2 3 4 67
  2. The EVI5 TBC domain provides the GTPase-activating protein motif for RAB11. (PMID: 17099728) Dabbeekeh J.T. … Cowell J.K. (Oncogene 2007) 3 23
  3. EVI5 protein associates with the INCENP-aurora B kinase-survivin chromosomal passenger complex and is involved in the completion of cytokinesis. (PMID: 16764853) Faitar S.L. … Cowell J.K. (Exp. Cell Res. 2006) 3 23
  4. EVI5 is a novel centrosomal protein that binds to alpha- and gamma- tubulin. (PMID: 16033705) Faitar S.L. … Cowell J.K. (Genomics 2005) 3 23
  5. MicroRNA-135b, a HSF1 target, promotes tumor invasion and metastasis by regulating RECK and EVI5 in hepatocellular carcinoma. (PMID: 25537516) Li Y. … He X. (Oncotarget 2015) 3

Products for EVI5 Gene

Sources for EVI5 Gene

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