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Aliases for EVI5 Gene

Aliases for EVI5 Gene

  • Ecotropic Viral Integration Site 5 2 3 5
  • Neuroblastoma Stage 4S Gene Protein 3 4
  • EVI-5 3 4
  • NB4S 3 4
  • Ecotropic Viral Integration Site 5 Protein Homolog 3
  • DJ846D11.1 (Ecotropic Viral Integration Site 5) 3
  • Neuroblastoma Stage 4S Gene 2

External Ids for EVI5 Gene

Previous GeneCards Identifiers for EVI5 Gene

  • GC01M093448
  • GC01M092183
  • GC01M092311
  • GC01M092691
  • GC01M092746
  • GC01M092974
  • GC01M091095

Summaries for EVI5 Gene

GeneCards Summary for EVI5 Gene

EVI5 (Ecotropic Viral Integration Site 5) is a Protein Coding gene. Diseases associated with EVI5 include Neuroblastoma and Interleukin-7 Receptor Alpha Deficiency. Among its related pathways are Aurora B signaling. GO annotations related to this gene include GTPase activator activity and Rab GTPase binding. An important paralog of this gene is EVI5L.

UniProtKB/Swiss-Prot for EVI5 Gene

  • Functions as a regulator of cell cycle progression by stabilizing the FBXO5 protein and promoting cyclin-A accumulation during interphase. May play a role in cytokinesis.

Gene Wiki entry for EVI5 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for EVI5 Gene

Genomics for EVI5 Gene

Regulatory Elements for EVI5 Gene

Enhancers for EVI5 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH01F092858 1.5 FANTOM5 Ensembl ENCODE 20.9 -66.9 -66897 1.0 ARNT ZNF133 ARID4B FEZF1 ZNF2 YY1 CBX5 ZNF143 FOS YY2 SNORD21 EVI5 RPL5 RNU6-970P GC01M092852 LOC100127934
GH01F092949 1.3 Ensembl ENCODE 21.7 -159.6 -159597 5.2 HDGF ATF1 ZNF133 ARID4B DMAP1 ZNF48 YY1 SP5 MXD4 MIER2 FAM69A EVI5 SNORA66 SNORD21 RPL5 GC01P092958 GC01P092939
GH01F092536 1.6 FANTOM5 Ensembl ENCODE 15.5 +254.7 254734 3.1 HDGF PKNOX1 MLX YBX1 DMAP1 YY1 JUNB TBX21 PPARG KAT8 EVI5 FAM69A RPAP2 GLMN GFI1 RPL5 GC01P092533 GC01P092559
GH01F092482 1.4 FANTOM5 ENCODE 17.2 +307.5 307520 5.3 HDGF SIN3A ARID4B DMAP1 ZNF2 YY1 ZNF143 ZNF207 SP3 SP5 FAM69A EVI5 CCDC18-AS1 SNORA66 SNORD21 BTBD8 GFI1 GC01P092471
GH01F092503 1.2 Ensembl ENCODE 17.6 +287.3 287335 2.6 ELF3 TBP THRB RAD21 RARA YY1 GATA4 SCRT2 CREM MIXL1 FAM69A EVI5 GC01P092511 GFI1
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around EVI5 on UCSC Golden Path with GeneCards custom track

Genomic Location for EVI5 Gene

Chromosome:
1
Start:
92,508,696 bp from pter
End:
92,792,404 bp from pter
Size:
283,709 bases
Orientation:
Minus strand

Genomic View for EVI5 Gene

Genes around EVI5 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
EVI5 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for EVI5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for EVI5 Gene

Proteins for EVI5 Gene

  • Protein details for EVI5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O60447-EVI5_HUMAN
    Recommended name:
    Ecotropic viral integration site 5 protein homolog
    Protein Accession:
    O60447
    Secondary Accessions:
    • A6NKX8
    • B9A6J0
    • Q9H1Y9

    Protein attributes for EVI5 Gene

    Size:
    810 amino acids
    Molecular mass:
    92949 Da
    Quaternary structure:
    • Dimeric and monomeric. Interacts with alpha- and gamma-tubulin. Interacts with FBXO5. Interacts with the chromosome passenger complex (CPC) which is at least composed of AURKB/aurora-B, BIRC5/survivin, CDCA8/borealin and INCENP.
    Miscellaneous:
    • Depletion of EVI5 by RNAi causes cell cycle arrest and mitotic abnormalities.

    Alternative splice isoforms for EVI5 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for EVI5 Gene

Post-translational modifications for EVI5 Gene

  • Probably phosphorylated by PLK1; may be required for degradation during mitosis.
  • Ubiquitinated. Degradation during prophase is ubiquitin-dependent.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for EVI5 Gene

Domains & Families for EVI5 Gene

Suggested Antigen Peptide Sequences for EVI5 Gene

Graphical View of Domain Structure for InterPro Entry

O60447

UniProtKB/Swiss-Prot:

EVI5_HUMAN :
  • Contains 1 Rab-GAP TBC domain.
Domain:
  • Contains 1 Rab-GAP TBC domain.
genes like me logo Genes that share domains with EVI5: view

No data available for Gene Families for EVI5 Gene

Function for EVI5 Gene

Molecular function for EVI5 Gene

GENATLAS Biochemistry:
ecotropic viral integration site 5,neuroblastoma,infant from stage 4S candidate gene,widely expressed,homolog to HRP1 (TRE-2) and mouse TBC1,fused with TRNG10 to form a chimeric fusion protein in constitutional translocation t(1;10)(p22;q21)
UniProtKB/Swiss-Prot Function:
Functions as a regulator of cell cycle progression by stabilizing the FBXO5 protein and promoting cyclin-A accumulation during interphase. May play a role in cytokinesis.
UniProtKB/Swiss-Prot Induction:
Down-regulated during mitosis through proteasomal degradation.

Gene Ontology (GO) - Molecular Function for EVI5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005096 GTPase activator activity IDA 17562788
GO:0005515 protein binding IPI 16439210
GO:0017137 Rab GTPase binding IPI 17562788
genes like me logo Genes that share ontologies with EVI5: view
genes like me logo Genes that share phenotypes with EVI5: view

Animal Models for EVI5 Gene

MGI Knock Outs for EVI5:
  • Evi5 tm1a(KOMP)Wtsi

Animal Model Products

miRNA for EVI5 Gene

miRTarBase miRNAs that target EVI5

Inhibitory RNA Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for EVI5 Gene

Localization for EVI5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for EVI5 Gene

Nucleus. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, cytoskeleton, spindle. Note=Associates with the mitotic spindle through anaphase and remains within the midzone and midbody until completion of cytokinesis.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for EVI5 gene
Compartment Confidence
cytoskeleton 5
nucleus 5
cytosol 5
golgi apparatus 2
endosome 1

Gene Ontology (GO) - Cellular Components for EVI5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005737 cytoplasm IEA --
GO:0005794 Golgi apparatus IDA --
GO:0005815 microtubule organizing center IEA --
GO:0005819 spindle IEA --
genes like me logo Genes that share ontologies with EVI5: view

Pathways & Interactions for EVI5 Gene

SuperPathway Contained pathways
1 Aurora B signaling
genes like me logo Genes that share pathways with EVI5: view

Pathways by source for EVI5 Gene

1 BioSystems pathway for EVI5 Gene

SIGNOR curated interactions for EVI5 Gene

Inactivates:

Gene Ontology (GO) - Biological Process for EVI5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006886 intracellular protein transport IBA --
GO:0007049 cell cycle IEA --
GO:0007275 multicellular organism development TAS 9618176
GO:0008283 cell proliferation TAS 9618176
GO:0031338 regulation of vesicle fusion IBA --
genes like me logo Genes that share ontologies with EVI5: view

Transcripts for EVI5 Gene

Unigene Clusters for EVI5 Gene

Ecotropic viral integration site 5:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for EVI5 Gene

No ASD Table

Relevant External Links for EVI5 Gene

GeneLoc Exon Structure for
EVI5
ECgene alternative splicing isoforms for
EVI5

Expression for EVI5 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for EVI5 Gene

Protein differential expression in normal tissues from HIPED for EVI5 Gene

This gene is overexpressed in Bone marrow mesenchymal stem cell (50.1) and Plasma (6.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for EVI5 Gene



NURSA nuclear receptor signaling pathways regulating expression of EVI5 Gene:

EVI5

SOURCE GeneReport for Unigene cluster for EVI5 Gene:

Hs.594434

mRNA Expression by UniProt/SwissProt for EVI5 Gene:

O60447-EVI5_HUMAN
Tissue specificity: Expressed in various cell lines (at protein level). Expressed in a wide range of tissues including brain and adrenal.
genes like me logo Genes that share expression patterns with EVI5: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Protein tissue co-expression partners for EVI5 Gene

Orthologs for EVI5 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for EVI5 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia EVI5 34 35
  • 99.71 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia EVI5 35
  • 94 (a)
OneToOne
dog
(Canis familiaris)
Mammalia EVI5 34 35
  • 91.81 (n)
cow
(Bos Taurus)
Mammalia EVI5 34 35
  • 91.79 (n)
mouse
(Mus musculus)
Mammalia Evi5 34 16 35
  • 89.2 (n)
rat
(Rattus norvegicus)
Mammalia Evi5 34
  • 87.14 (n)
oppossum
(Monodelphis domestica)
Mammalia EVI5 35
  • 83 (a)
OneToOne
chicken
(Gallus gallus)
Aves EVI5 34 35
  • 72.36 (n)
lizard
(Anolis carolinensis)
Reptilia EVI5 35
  • 79 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia evi5 34
  • 65.86 (n)
Str.3031 34
African clawed frog
(Xenopus laevis)
Amphibia Xl.12898 34
zebrafish
(Danio rerio)
Actinopterygii evi5b 34 35
  • 72.21 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP002354 34
  • 51.49 (n)
fruit fly
(Drosophila melanogaster)
Insecta Evi5 34
  • 49.31 (n)
CG11727 36 35
  • 30 (a)
worm
(Caenorhabditis elegans)
Secernentea tbc-4 34
  • 55.04 (n)
T24D11.1 36
  • 50 (a)
eat-17 35
  • 34 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes GYP5 35
  • 18 (a)
ManyToMany
GYL1 35 37
  • 16 (a)
ManyToMany
thale cress
(Arabidopsis thaliana)
eudicotyledons AT3G02460 34
  • 52.04 (n)
rice
(Oryza sativa)
Liliopsida Os08g0412600 34
  • 50.89 (n)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.3125 35
  • 45 (a)
OneToMany
Species where no ortholog for EVI5 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for EVI5 Gene

ENSEMBL:
Gene Tree for EVI5 (if available)
TreeFam:
Gene Tree for EVI5 (if available)

Paralogs for EVI5 Gene

Paralogs for EVI5 Gene

(8) SIMAP similar genes for EVI5 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with EVI5: view

Variants for EVI5 Gene

Sequence variations from dbSNP and Humsavar for EVI5 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs1003116 -- 92,700,844(+) CAATA(C/T)TAAAT intron-variant
rs1003209 -- 92,536,507(+) TATCA(C/T)TGAAA intron-variant
rs10127800 -- 92,575,310(+) GGTGT(C/T)ATGAC intron-variant
rs10127891 -- 92,578,011(+) CGCTA(C/T)GGTGC intron-variant
rs10159031 -- 92,613,933(+) TTGCC(A/C)CTCCA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for EVI5 Gene

Variant ID Type Subtype PubMed ID
nsv997898 CNV gain 25217958
nsv955453 CNV deletion 24416366
nsv830603 CNV loss 17160897
nsv523354 CNV gain 19592680
nsv475722 CNV novel sequence insertion 20440878
nsv159896 CNV insertion 16902084
nsv1141898 OTHER inversion 24896259
nsv1008602 CNV gain 25217958
nsv1004381 CNV gain 25217958
esv3586819 CNV loss 21293372
esv3586818 CNV loss 21293372
esv3586817 CNV loss 21293372
esv3586816 CNV loss 21293372
esv3586814 CNV loss 21293372
esv3586812 CNV loss 21293372
esv3578012 CNV loss 25503493
esv3578011 CNV loss 25503493
esv3565848 CNV deletion 23714750
esv3565837 CNV deletion 23714750
esv3442538 CNV insertion 20981092
esv2714684 CNV deletion 23290073
esv2674141 CNV deletion 23128226
esv2669727 CNV deletion 23128226
esv2656994 CNV deletion 23128226
esv2533438 CNV insertion 19546169
esv1938423 CNV deletion 18987734
esv1233172 CNV insertion 17803354
esv1001160 CNV insertion 20482838

Variation tolerance for EVI5 Gene

Residual Variation Intolerance Score: 86.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 9.27; 88.16% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for EVI5 Gene

Human Gene Mutation Database (HGMD)
EVI5
SNPedia medical, phenotypic, and genealogical associations of SNPs for
EVI5

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for EVI5 Gene

Disorders for EVI5 Gene

MalaCards: The human disease database

(2) MalaCards diseases for EVI5 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
neuroblastoma
  • neuroblastoma 1
interleukin-7 receptor alpha deficiency
  • il-7r
- elite association - COSMIC cancer census association via MalaCards
Search EVI5 in MalaCards View complete list of genes associated with diseases

UniProtKB/Swiss-Prot

EVI5_HUMAN
  • Note=A chromosomal aberration involving EVI5 is found is a patient with stage 4S neuroblastoma. Translocation t(1;10)(p22;q21) that forms a EVI5-TRNG10 fusion protein. TRNG10 is a probable structural transcript which is normally not translated. {ECO:0000269 PubMed:9618176}.

Relevant External Links for EVI5

Genetic Association Database (GAD)
EVI5
Human Genome Epidemiology (HuGE) Navigator
EVI5
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
EVI5
genes like me logo Genes that share disorders with EVI5: view

No data available for Genatlas for EVI5 Gene

Publications for EVI5 Gene

  1. EVI5 protein associates with the INCENP-aurora B kinase-survivin chromosomal passenger complex and is involved in the completion of cytokinesis. (PMID: 16764853) Faitar S.L. … Cowell J.K. (Exp. Cell Res. 2006) 3 4 22 64
  2. EVI5 is a novel centrosomal protein that binds to alpha- and gamma- tubulin. (PMID: 16033705) Faitar S.L. … Cowell J.K. (Genomics 2005) 3 4 22 64
  3. NB4S, a member of the TBC1 domain family of genes, is truncated as a result of a constitutional t(1;10)(p22;q21) chromosome translocation in a patient with stage 4S neuroblastoma. (PMID: 9618176) Roberts T. … Cowell J.K. (Hum. Mol. Genet. 1998) 2 3 4 64
  4. Multiple sclerosis susceptibility alleles in African Americans. (PMID: 19865102) Johnson B.A. … Oksenberg J.R. (Genes Immun. 2010) 3 46 64
  5. Tag-SNP analysis of the GFI1-EVI5-RPL5-FAM69 risk locus for multiple sclerosis. (PMID: 20087403) Alcina A. … Matesanz F. (Eur. J. Hum. Genet. 2010) 3 46 64

Products for EVI5 Gene

Sources for EVI5 Gene

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