Free for academic non-profit institutions. Other users need a Commercial license

Aliases for EVI5 Gene

Aliases for EVI5 Gene

  • Ecotropic Viral Integration Site 5 2 3
  • NB4S 3 4 6
  • Neuroblastoma Stage 4S Gene Protein 3 4
  • EVI-5 3 4
  • Ecotropic Viral Integration Site 5 Protein Homolog 3
  • DJ846D11.1 (Ecotropic Viral Integration Site 5) 3
  • Neuroblastoma Stage 4S Gene 2

External Ids for EVI5 Gene

Previous GeneCards Identifiers for EVI5 Gene

  • GC01M093448
  • GC01M092183
  • GC01M092311
  • GC01M092691
  • GC01M092746
  • GC01M092974
  • GC01M091095

Summaries for EVI5 Gene

GeneCards Summary for EVI5 Gene

EVI5 (Ecotropic Viral Integration Site 5) is a Protein Coding gene. Diseases associated with EVI5 include neuroblastoma. Among its related pathways are Aurora B signaling. An important paralog of this gene is RABGAP1L.

UniProtKB/Swiss-Prot for EVI5 Gene

  • Functions as a regulator of cell cycle progression by stabilizing the FBXO5 protein and promoting cyclin-A accumulation during interphase. May play a role in cytokinesis.

Gene Wiki entry for EVI5 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for EVI5 Gene

Genomics for EVI5 Gene

Regulatory Elements for EVI5 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for EVI5 Gene

Start:
92,508,696 bp from pter
End:
92,792,404 bp from pter
Size:
283,709 bases
Orientation:
Minus strand

Genomic View for EVI5 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for EVI5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for EVI5 Gene

Proteins for EVI5 Gene

  • Protein details for EVI5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O60447-EVI5_HUMAN
    Recommended name:
    Ecotropic viral integration site 5 protein homolog
    Protein Accession:
    O60447
    Secondary Accessions:
    • A6NKX8
    • B9A6J0
    • Q9H1Y9

    Protein attributes for EVI5 Gene

    Size:
    810 amino acids
    Molecular mass:
    92949 Da
    Quaternary structure:
    • Dimeric and monomeric. Interacts with alpha- and gamma-tubulin. Interacts with FBXO5. Interacts with the chromosome passenger complex (CPC) which is at least composed of AURKB/aurora-B, BIRC5/survivin, CDCA8/borealin and INCENP.
    Miscellaneous:
    • Depletion of EVI5 by RNAi causes cell cycle arrest and mitotic abnormalities

    Alternative splice isoforms for EVI5 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for EVI5 Gene

Proteomics data for EVI5 Gene at MOPED

Post-translational modifications for EVI5 Gene

  • Probably phosphorylated by PLK1; may be required for degradation during mitosis.
  • Ubiquitinated. Degradation during prophase is ubiquitin-dependent.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for EVI5 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for EVI5 Gene

Domains for EVI5 Gene

Suggested Antigen Peptide Sequences for EVI5 Gene

Graphical View of Domain Structure for InterPro Entry

O60447

UniProtKB/Swiss-Prot:

EVI5_HUMAN :
  • O60447
Domain:
  • Contains 1 Rab-GAP TBC domain.
genes like me logo Genes that share domains with EVI5: view

No data available for Gene Families for EVI5 Gene

Function for EVI5 Gene

Molecular function for EVI5 Gene

GENATLAS Biochemistry: ecotropic viral integration site 5,neuroblastoma,infant from stage 4S candidate gene,widely expressed,homolog to HRP1 (TRE-2) and mouse TBC1,fused with TRNG10 to form a chimeric fusion protein in constitutional translocation t(1;10)(p22;q21)
UniProtKB/Swiss-Prot Function: Functions as a regulator of cell cycle progression by stabilizing the FBXO5 protein and promoting cyclin-A accumulation during interphase. May play a role in cytokinesis.
UniProtKB/Swiss-Prot Induction: Down-regulated during mitosis through proteasomal degradation.

Gene Ontology (GO) - Molecular Function for EVI5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005096 GTPase activator activity IDA 17562788
GO:0005515 protein binding IPI 16439210
GO:0017137 Rab GTPase binding IPI 17562788
genes like me logo Genes that share ontologies with EVI5: view

Phenotypes for EVI5 Gene

GenomeRNAi human phenotypes for EVI5:
genes like me logo Genes that share phenotypes with EVI5: view

Animal Model Products

CRISPR Products

miRNA for EVI5 Gene

miRTarBase miRNAs that target EVI5

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for EVI5

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for EVI5 Gene

Localization for EVI5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for EVI5 Gene

Nucleus. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, cytoskeleton, spindle. Note=Associates with the mitotic spindle through anaphase and remains within the midzone and midbody until completion of cytokinesis.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for EVI5 Gene COMPARTMENTS Subcellular localization image for EVI5 gene
Compartment Confidence
cytoskeleton 5
nucleus 5
cytosol 2
endosome 1

Gene Ontology (GO) - Cellular Components for EVI5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005794 Golgi apparatus IDA --
GO:0005815 microtubule organizing center IEA --
GO:0005819 spindle IEA --
GO:0005829 cytosol IDA 17562788
genes like me logo Genes that share ontologies with EVI5: view

Pathways for EVI5 Gene

SuperPathways for EVI5 Gene

Superpath Contained pathways
1 Aurora B signaling
genes like me logo Genes that share pathways with EVI5: view

Pathways by source for EVI5 Gene

1 BioSystems pathway for EVI5 Gene

Gene Ontology (GO) - Biological Process for EVI5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007049 cell cycle IEA --
GO:0007275 multicellular organismal development TAS 9618176
GO:0008283 cell proliferation TAS 9618176
GO:0033126 obsolete positive regulation of GTP catabolic process --
GO:0042147 retrograde transport, endosome to Golgi IMP 17562788
genes like me logo Genes that share ontologies with EVI5: view

Transcripts for EVI5 Gene

Unigene Clusters for EVI5 Gene

Ecotropic viral integration site 5:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for EVI5

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for EVI5

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for EVI5 Gene

No ASD Table

Relevant External Links for EVI5 Gene

GeneLoc Exon Structure for
EVI5
ECgene alternative splicing isoforms for
EVI5

Expression for EVI5 Gene

mRNA expression in normal human tissues for EVI5 Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for EVI5 Gene

SOURCE GeneReport for Unigene cluster for EVI5 Gene Hs.594434

mRNA Expression by UniProt/SwissProt for EVI5 Gene

O60447-EVI5_HUMAN
Tissue specificity: Expressed in various cell lines (at protein level). Expressed in a wide range of tissues including brain and adrenal.
genes like me logo Genes that share expressions with EVI5: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for EVI5 Gene

Orthologs for EVI5 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for EVI5 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia EVI5 35
  • 99.71 (n)
  • 99.63 (a)
EVI5 36
  • 98 (a)
OneToOne
cow
(Bos Taurus)
Mammalia EVI5 35
  • 91.79 (n)
  • 94.07 (a)
EVI5 36
  • 94 (a)
OneToOne
dog
(Canis familiaris)
Mammalia EVI5 35
  • 91.81 (n)
  • 93.64 (a)
EVI5 36
  • 97 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Evi5 35
  • 89.2 (n)
  • 91.72 (a)
Evi5 16
Evi5 36
  • 92 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia EVI5 36
  • 83 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia EVI5 36
  • 94 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Evi5 35
  • 87.14 (n)
  • 90.73 (a)
chicken
(Gallus gallus)
Aves EVI5 35
  • 72.36 (n)
  • 70.29 (a)
EVI5 36
  • 87 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia EVI5 36
  • 79 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.12898 35
tropical clawed frog
(Silurana tropicalis)
Amphibia evi5 35
  • 65.86 (n)
  • 65.19 (a)
Str.3031 35
zebrafish
(Danio rerio)
Actinopterygii evi5b 35
  • 72.21 (n)
  • 81 (a)
evi5b 36
  • 76 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP002354 35
  • 51.49 (n)
  • 51.84 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG11727 36
  • 40 (a)
OneToMany
Evi5 35
  • 49.31 (n)
  • 48.62 (a)
CG11727 37
  • 30 (a)
worm
(Caenorhabditis elegans)
Secernentea eat-17 36
  • 34 (a)
OneToMany
tbc-4 35
  • 55.04 (n)
  • 51.74 (a)
T24D11.1 37
  • 50 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes GYL1 36
  • 16 (a)
ManyToMany
GYL1 38
GYP5 36
  • 18 (a)
ManyToMany
thale cress
(Arabidopsis thaliana)
eudicotyledons AT3G02460 35
  • 52.04 (n)
  • 41.01 (a)
rice
(Oryza sativa)
Liliopsida Os08g0412600 35
  • 50.89 (n)
  • 39.02 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.3125 36
  • 45 (a)
OneToMany
Species with no ortholog for EVI5:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for EVI5 Gene

ENSEMBL:
Gene Tree for EVI5 (if available)
TreeFam:
Gene Tree for EVI5 (if available)

Paralogs for EVI5 Gene

Paralogs for EVI5 Gene

Selected SIMAP similar genes for EVI5 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with EVI5: view

Variants for EVI5 Gene

Sequence variations from dbSNP and Humsavar for EVI5 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs552675 -- 92,633,574(-) TCTCA(A/C/G/T)GTGCA intron-variant
rs722356 -- 92,516,848(-) TCTGC(C/T)TGCTT intron-variant
rs723909 -- 92,708,613(+) cttag(G/T)tatat intron-variant
rs757469 -- 92,724,549(+) atgcc(C/T)gtaat intron-variant
rs911523 -- 92,696,163(+) ctggg(C/T)tcaag intron-variant

Structural Variations from Database of Genomic Variants (DGV) for EVI5 Gene

Variant ID Type Subtype PubMed ID
esv2714684 CNV Deletion 23290073
nsv523354 CNV Gain 19592680
nsv830603 CNV Loss 17160897
esv2533438 CNV Insertion 19546169
esv269509 CNV Insertion 20981092
esv274271 CNV Insertion 20981092
esv1001160 CNV Insertion 20482838
esv1233172 CNV Insertion 17803354
nsv159896 CNV Insertion 16902084
esv2656994 CNV Deletion 23128226
esv2669727 CNV Deletion 23128226
nsv871263 CNV Loss 21882294
esv1938423 CNV Deletion 18987734
esv2674141 CNV Deletion 23128226

Relevant External Links for EVI5 Gene

HapMap Linkage Disequilibrium report
EVI5
Human Gene Mutation Database (HGMD)
EVI5

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for EVI5 Gene

Disorders for EVI5 Gene

MalaCards: The human disease database

MalaCards: The human disease database. (1) Diseases for EVI5 Gene including...

Search for EVI5 Gene in MalaCards »

UniProtKB/Swiss-Prot

EVI5_HUMAN
  • Note=A chromosomal aberration involving EVI5 is found is a patient with stage 4S neuroblastoma. Translocation t(1;10)(p22;q21) that forms a EVI5-TRNG10 fusion protein. TRNG10 is a probable structural transcript which is normally not translated. {ECO:0000269 PubMed:9618176}.

Relevant External Links for EVI5

Genetic Association Database (GAD)
EVI5
Human Genome Epidemiology (HuGE) Navigator
EVI5
genes like me logo Genes that share disorders with EVI5: view

Publications for EVI5 Gene

  1. EVI5 is a novel centrosomal protein that binds to alpha- and gamma- tubulin. (PMID: 16033705) Faitar S.L. … Cowell J.K. (Genomics 2005) 3 4 23
  2. EVI5 protein associates with the INCENP-aurora B kinase-survivin chromosomal passenger complex and is involved in the completion of cytokinesis. (PMID: 16764853) Faitar S.L. … Cowell J.K. (Exp. Cell Res. 2006) 3 4 23
  3. NB4S, a member of the TBC1 domain family of genes, is truncated as a result of a constitutional t(1;10)(p22;q21) chromosome translocation in a patient with stage 4S neuroblastoma. (PMID: 9618176) Roberts T. … Cowell J.K. (Hum. Mol. Genet. 1998) 2 3 4
  4. The EVI5 TBC domain provides the GTPase-activating protein motif for RAB11. (PMID: 17099728) Dabbeekeh J.T. … Cowell J.K. (Oncogene 2007) 3 23
  5. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory S.G. … Bentley D.R. (Nature 2006) 3 4

Products for EVI5 Gene

Sources for EVI5 Gene

Back to Top

Content