EVI5 Gene
protein-coding GIFtS: 59
GCID: GC01M092974
|
|
ecotropic viral integration site 5
| |
Aliases for EVI5 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb) About This Section
|
| Aliases |
|---|
| Ecotropic Viral Integration Site 51 2 | | NB4S1 2 3 5 | | Neuroblastoma Stage 4S Gene Protein2 3 | | EVI-52 3 | | DJ846D11.1 (Ecotropic Viral Integration Site 5)2 | | Ecotropic Viral Integration Site 5 Protein Homolog2 |
Export aliases for EVI5 gene to outside databasesPrevious GC identifers: GC01M093448 GC01M092183 GC01M092311 GC01M092446 GC01M092691 GC01M092746 GC01M091095 |
Summaries for EVI5 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
| UniProtKB/Swiss-Prot: EVI5_HUMAN, O60447Function: Functions as a regulator of cell cycle progression by stabilizing the FBXO5 protein and promoting cyclin-Aaccumulation during interphase. May play a role in cytokinesis Gene Wiki entry for EVI5
|
Genomic Views for EVI5 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics) About This Section
| RefSeq DNA sequence:- NC_000001.10 NC_018912.1 NT_032977.9
Regulatory elements: SABiosciences Regulatory transcription factor binding sites in the EVI5 gene promoter: c-Fos p53 HNF-1A C/EBPalpha CHOP-10 MEF-2A HNF-1 c-Jun aMEF-2 RSRFC4 Other transcription factors
Search SABiosciences Chromatin IP Primers for EVI5
Epigenetics:
|  | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat EVI5 |
Genomic Location: Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 1p22.1 Ensembl cytogenetic band: 1p22.1 HGNC cytogenetic band: 1p22EVI5 Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different)

GeneLoc information about chromosome 1 GeneLoc Exon Structure GeneLoc location for GC01M092974: view genomic region
(about GC identifiers)
Start:
|
92,974,253 bp from pter |
End:
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93,257,961 bp from pter |
Size:
|
283,709 bases |
Orientation:
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minus strand |
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Proteins for EVI5 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
| UniProtKB/Swiss-Prot: EVI5_HUMAN, O60447 (See
protein sequence)Recommended Name: Ecotropic viral integration site 5 protein homolog Size: 810 amino acids; 92949 Da
Subunit: Dimeric and monomeric. Interacts with alpha- and gamma-tubulin. Interacts with FBXO5. Interacts with thechromosome passenger complex (CPC) which is at least composed of AURKB/aurora-B, BIRC5/survivin, CDCA8/borealin andINCENP
Subcellular location: Nucleus. Cytoplasm, cytoskeleton, centrosome. Cytoplasm, cytoskeleton, spindle. Note=Associateswith the mitotic spindle through anaphase and remains within the midzone and midbody until completion of cytokinesis
Miscellaneous: Depletion of EVI5 by RNAi causes cell cycle arrest and mitotic abnormalities
Secondary accessions: A6NKX8 Q9H1Y9Explore the universe of human proteins at neXtProt for EVI5: NX_O60447
Post-translational modifications:
Probably phosphorylated by PLK1; may be required for degradation during mitosis1
Ubiquitinated. Degradation during prophase is ubiquitin-dependent1
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_O60447 EVI5 Protein expression data from MOPED and PaxDb: About this image 
 REFSEQ proteins: NP_005656.4 ENSEMBL proteins: ENSP00000359356 ENSP00000440826 ENSP00000445019 Human Recombinant Protein Products for EVI5:
Gene Ontology (GO): 5 cellular component terms (GO ID links to tree view): About this table
EVI5 for ontologies About GeneDecksing
EVI5 Antibody Products: Assay Products for EVI5: |
Protein
Domains / Families for EVI5 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
EVI5 for domains About GeneDecksing
1 InterPro domain/family:Graphical View of Domain Structure for InterPro Entry O60447ProtoNet protein and cluster: O60447 2 Blocks protein families: IPB000195 RabGAP/TBC domain IPB000515 Binding-protein-dependent transport systems inner membrane component
UniProtKB/Swiss-Prot: EVI5_HUMAN, O60447Similarity: Contains 1 Rab-GAP TBC domain |
Function for EVI5 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
inGenious Targeting Laboratory,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase,
shRNA from
OriGene,
Sirion Biotech,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Sirion Biotech,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
Sirion Biotech,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
| Molecular Function: UniProtKB/Swiss-Prot Summary: EVI5_HUMAN, O60447Function: Functions as a regulator of cell cycle progression by stabilizing the FBXO5 protein and promoting cyclin-Aaccumulation during interphase. May play a role in cytokinesisInduction: Down-regulated during mitosis through proteasomal degradation Genatlas biochemistry entry for EVI5:ecotropic viral integration site 5,neuroblastoma,infant from stage 4S candidate gene,widely expressed,homolog to HRP1(TRE-2) and mouse TBC1,fused with TRNG10 to form a chimeric fusion protein in constitutional translocationt(1;10)(p22;q21)
Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view): About this table
EVI5 for ontologies About GeneDecksing
Phenotypes: 2 GenomeRNAi human phenotypes for EVI5: Animal Models:
Clone Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for EVI5 (see all 2) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for EVI5 OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
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Synthesis Service for EVI5 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat EVI5  |
In Situ Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for EVI5 |
|
Pathways & Interactions for EVI5 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
| Unified GeneCards pathways  About this table  See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Aurora B signaling | |
1 BioSystems Pathway for EVI5 
Interactions:
SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for EVI5
STRING Interaction
Network Preview (showing 5 interactants - click image to see 7)
 5/39 Interacting proteins for EVI5 (O604471, 3 ENSP000003593564) via UniProtKB, MINT, STRING, and/or I2D (see all 39)About this table
Gene Ontology (GO): 4 biological process terms (GO ID links to tree view): About this table
EVI5 for ontologies About GeneDecksing
|
Drugs & Compounds for EVI5 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
Browse Tocris compounds for EVI5 Search CenterWatch for drugs/clinical trials and news about EVI5 
|
Transcripts for EVI5 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank, RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
Sirion Biotech,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
) About This Section
| REFSEQ mRNAs for EVI5 gene: NM_005665.4 Unigene Cluster for EVI5: Ecotropic viral integration site 5 Hs.594434 [show with all ESTs]Unigene Representative Sequence: NM_0056659 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000370331(uc001dox.3 uc010otf.2) ENST00000491940 ENST00000492513 ENST00000468580 ENST00000492613 ENST00000474806 ENST00000466778 ENST00000540033 ENST00000543509(uc001doy.1)
Clone Products: |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for EVI5 (see all 2) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for EVI5 OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: EVI5 (NM_005665) | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for EVI5 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat EVI5  |
Additional cDNA sequence: AB209513.1 AB449875.1 AF008915.1 11 DOTS entries: DT.416560 DT.95324473 DT.95264988 DT.101968109 DT.100714794 DT.40132263 DT.91717004 DT.92009937 DT.95339072 DT.121402397 DT.92042891 24/110 AceView cDNA sequences (see all 110): AA725529 BF060772 BM835541 AA478513 BG943103 AA693846 AA362568 AA772947 BF435186 C02379 F05844 AA478512 BX098889 BG259900 AI635805 Z38177 CD106262 F05127 AA262153 AA628572 Z42583 F02094 BX093275 BU685559 GeneLoc Exon Structure
|
Expression for EVI5 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| EVI5 expression in normal human tissues (normalized intensities) See probesets specificity/sensitivity at GeneAnnot About this imageBioGPS CGAP TAG: AAATCAGTTA
 About this image See EVI5 Protein Expression from SPIRE MOPED and PaxDB Genevestigator expression for EVI5
SOURCE GeneReport for Unigene cluster: Hs.594434
UniProtKB/Swiss-Prot: EVI5_HUMAN, O60447Tissue specificity: Expressed in various cell lines (at protein level). Expressed in a wide range of tissues includingbrain and adrenal SABiosciences Custom PCR Arrays for EVI5
Primer Products: |  | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for EVI5 Browse OriGene validated miRNA SYBR primer pairs
| |  | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat EVI5 | |  | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat EVI5 | |  | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat EVI5 | In Situ Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for EVI5 |
Orthologs for EVI5 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of eukaryotes.
Orthologs for EVI5 gene from 8/26 species (see all 26) About this table
| Organism |
Taxonomic classification |
Gene |
Description |
Human Similarity |
Orthology Type |
Details |
chicken (Gallus gallus) |
Aves |
EVI56 |
Uncharacterized protein |
87(a) |
1 ↔ 1 |
8(14756146-14805212) |
lizard (Anolis carolinensis) |
Reptilia |
EVI56 |
-- |
83(a) |
1 ↔ 1 |
4(93598863-93662388) |
African clawed frog (Xenopus laevis) |
Amphibia |
Xl.128982 |
Xenopus laevis transcribed sequence with moderate similarity more |
76.07(n) |
  |
BG555915.1 |
zebrafish (Danio rerio) |
Actinopterygii |
evi5b6CU855813.16 |
-- |
76(a)43(a) |
1 ↔ many1 ↔ many |
6(28725707-28800269) 2(10501363-10526503) |
fruit fly (Drosophila melanogaster) |
Insecta |
CG117273 |
-- |
30(a) |
  |
-- |
worm (Caenorhabditis elegans) |
Secernentea |
T24D11.13 |
-- |
50(a) |
  |
X(16436681-16438275) -- |
thale cress (Arabidopsis thaliana) |
eudicotyledons |
AT3G024601 |
RabGAP/TBC domain-containing protein |
49.78(n) 39.03(a) |
  |
821261 NM_111113.3 NP_566172.1 |
rice (Oryza sativa) |
Liliopsida |
Os08g04126001 |
hypothetical protein |
51.06(n) 39.02(a) |
  |
4345560 NM_001068330.1 NP_001061795.1 |
ENSEMBL Gene Tree for EVI5 (if available) TreeFam Gene Tree for EVI5 (if available)  |
Paralogs for EVI5 gene(Paralogs according to
1HomoloGene, 2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68) About This Section
| Paralogs for EVI5 gene
- RABGAP1L2 TBC1D122 TBC1D42 TBC1D142 TBC1D12 EVI5L2 RABGAP12
8 SIMAP similar genes for EVI5 using alignment to 3 protein entries: EVI5_HUMAN (see all proteins):EVI5L RABGAP1L TBC1D1 TBC1D10A RABGAP1 FLJ00288 TBC1D10C SGSM3
EVI5 for paralogs About GeneDecksing
|
Genomic Variants for EVI5 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical significance | Chr 1 pos | Sequence | # | AA Chg | Type | More | # | Allele freq | Pop | Total sample | More |
|---|
HapMap Linkage Disequilibrium report for EVI5 (92974253 - 93224253 bp, first 250kb of EVI5)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions) Database of Genomic Variants (DGV): 2 variations for EVI5 1 CNV: 43784 1 Indel: 97441 Human Gene Mutation Database (HGMD): EVI5
 | SABiosciences Cancer Mutation PCR Assays |
|  | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing EVI5 |
|
Disorders
/ Diseases for EVI5 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
EVI5 for disorders About GeneDecksing
OMIM gene information: 602942
OMIM disorders: --
UniProtKB/Swiss-Prot: EVI5_HUMAN, O60447
Note=A chromosomal aberration involving EVI5 is found is a patient with stage 4S neuroblastoma. Translocationt(1;10)(p22;q21) that forms a EVI5-TRNG10 fusion protein. TRNG10 is a probable structural transcript which is normallynot translated 2 diseases for EVI5: About MalaCardsneuroblastoma multiple sclerosis Human Genome Epidemiology (HuGE) Navigator: EVI5 (7 documents) Export disorders for EVI5 gene to outside databases
|
Publications for EVI5 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for EVI5 gene, integrated from 9 sources (see all 21): (articles sorted by number of sources associating them with EVI5) | |  | Utopia: connect your pdf to the dynamic world of online information |
- NB4S, a member of the TBC1 domain family of genes, is truncated as a result of a constitutional t(1;10)(p22;q21) chromosome translocation in a patient with stage 4S neuroblastoma. (PubMed id 9618176)1, 2, 3 Roberts T.... Cowell J.K. (1998)
- EVI5 protein associates with the INCENP-aurora B kinase-survivin chromosomal passenger complex and is involved in the completion of cytokinesis. (PubMed id 16764853)1, 2, 9 Faitar S.L.... Cowell J.K. (2006)
- EVI5 is a novel centrosomal protein that binds to alpha- and gamma- tubulin. (PubMed id 16033705)1, 2, 9 Faitar S.L.... Cowell J.K. (2005)
- The evi5 oncogene regulates cyclin accumulation by stabilizing the anaphase-promoting complex inhibitor emi1. (PubMed id 16439210)1, 2 Eldridge A.G.... Jackson P.K. (2006)
- The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)1, 2 Gregory S.G.... Bentley D.R. (2006)
- The EVI5 TBC domain provides the GTPase-activating protein motif for RAB11. (PubMed id 17099728)1, 9 Dabbeekeh J.T....Cowell J.K. (2007)
- Genetic risk and a primary role for cell-mediated immu ne mechanisms in multiple sclerosis. (PubMed id 21833088)1 ....Compston A. (2011)
- Biological, clinical and population relevance of 95 l oci for blood lipids. (PubMed id 20686565)1 Teslovich T.M....Kathiresan S. (2010)
- Tag-SNP analysis of the GFI1-EVI5-RPL5-FAM69 risk loc us for multiple sclerosis. (PubMed id 20087403)1 Alcina A....Matesanz F. (2010)
- Stem cell exhaustion due to Runx1 deficiency is preve nted by Evi5 activation in leukemogenesis. (PubMed id 20008790)1 Jacob B....Ito Y. (2010)
|
External Searches for EVI5 gene
(in PubMed,
OMIM, and NCBI Bookshelf) About This Section
|
|
Genome Databases showing EVI5 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing EVI5 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing EVI5 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL, Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot) About This Section
|
|
About This Section
| Patent Information for EVI5 gene: Search GeneIP for patents involving EVI5
GeneCards and IP: Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products for EVI5 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences, In Situ Hybridization Assays from Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory) About This Section
|
 | |
 | |
 |
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