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Aliases for EVI2B Gene

Aliases for EVI2B Gene

  • Ecotropic Viral Integration Site 2B 2 3 5
  • Ecotropic Viral Integration Site 2B Protein Homolog 3 4
  • EVI-2B 3 4
  • EVDB 3 4
  • CD361 Antigen 4
  • D17S376 3
  • CD361 3

External Ids for EVI2B Gene

Previous GeneCards Identifiers for EVI2B Gene

  • GC17P029671
  • GC17M031537
  • GC17M029480
  • GC17M029776
  • GC17M026654
  • GC17M029630
  • GC17M025842

Summaries for EVI2B Gene

GeneCards Summary for EVI2B Gene

EVI2B (Ecotropic Viral Integration Site 2B) is a Protein Coding gene.

Gene Wiki entry for EVI2B Gene

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for EVI2B Gene

Genomics for EVI2B Gene

Regulatory Elements for EVI2B Gene

Genomic Location for EVI2B Gene

31,302,870 bp from pter
31,314,389 bp from pter
11,520 bases
Minus strand

Genomic View for EVI2B Gene

Genes around EVI2B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
EVI2B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for EVI2B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for EVI2B Gene

Proteins for EVI2B Gene

  • Protein details for EVI2B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein EVI2B
    Protein Accession:
    Secondary Accessions:
    • B7Z4A7

    Protein attributes for EVI2B Gene

    448 amino acids
    Molecular mass:
    48666 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for EVI2B Gene


neXtProt entry for EVI2B Gene

Proteomics data for EVI2B Gene at MOPED

Post-translational modifications for EVI2B Gene

  • Glycosylation at Asn 50, Asn 114, and Asn 31
  • Modification sites at PhosphoSitePlus

Other Protein References for EVI2B Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for EVI2B Gene

Domains & Families for EVI2B Gene

Gene Families for EVI2B Gene

Protein Domains for EVI2B Gene


Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with EVI2B: view

No data available for UniProtKB/Swiss-Prot for EVI2B Gene

Function for EVI2B Gene

Molecular function for EVI2B Gene

GENATLAS Biochemistry:
murine myeloid leukemia associated gene (Evi-2) homolog B (embedded in NF1 first intron in opposite orientation),involved in melanocyte and keratinocyte differentiation,same as D17S376
genes like me logo Genes that share phenotypes with EVI2B: view

Animal Model Products

miRNA for EVI2B Gene

miRTarBase miRNAs that target EVI2B

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for EVI2B Gene

Localization for EVI2B Gene

Subcellular locations from UniProtKB/Swiss-Prot for EVI2B Gene

Membrane; Single-pass type I membrane protein.

Subcellular locations from

Jensen Localization Image for EVI2B Gene COMPARTMENTS Subcellular localization image for EVI2B gene
Compartment Confidence
plasma membrane 5
extracellular 3
nucleus 2
cytoskeleton 1
cytosol 1
endoplasmic reticulum 1
golgi apparatus 1
mitochondrion 1
peroxisome 1

No data available for Gene Ontology (GO) - Cellular Components for EVI2B Gene

Pathways & Interactions for EVI2B Gene

SuperPathways for EVI2B Gene

No Data Available

Interacting Proteins for EVI2B Gene

Gene Ontology (GO) - Biological Process for EVI2B Gene


No data available for Pathways by source and SIGNOR curated interactions for EVI2B Gene

Drugs & Compounds for EVI2B Gene

No Compound Related Data Available

Transcripts for EVI2B Gene

mRNA/cDNA for EVI2B Gene

Unigene Clusters for EVI2B Gene

Ecotropic viral integration site 2B:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for EVI2B Gene

No ASD Table

Relevant External Links for EVI2B Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for EVI2B Gene

mRNA expression in normal human tissues for EVI2B Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for EVI2B Gene

This gene is overexpressed in Serum (54.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MOPED, and MaxQB for EVI2B Gene

SOURCE GeneReport for Unigene cluster for EVI2B Gene Hs.5509

mRNA Expression by UniProt/SwissProt for EVI2B Gene

Tissue specificity: Bone marrow, peripheral blood mononuclear cells, fibroblasts and Epstein-Barr virus-transformed lymphoblastoid cell lines.
genes like me logo Genes that share expression patterns with EVI2B: view

Protein tissue co-expression partners for EVI2B Gene

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues for EVI2B Gene

Orthologs for EVI2B Gene

This gene was present in the common ancestor of mammals.

Orthologs for EVI2B Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia EVI2B 35
  • 82.51 (n)
  • 71.75 (a)
EVI2B 36
  • 69 (a)
(Canis familiaris)
Mammalia EVI2B 35
  • 85.38 (n)
  • 75.62 (a)
EVI2B 36
  • 74 (a)
(Mus musculus)
Mammalia Evi2b 35
  • 72.39 (n)
  • 58.47 (a)
Gm21975 16
Evi2b 36
  • 57 (a)
(Pan troglodytes)
Mammalia EVI2B 35
  • 99.4 (n)
  • 98.44 (a)
EVI2B 36
  • 95 (a)
(Rattus norvegicus)
Mammalia Evi2b 35
  • 73.28 (n)
  • 60.05 (a)
(Ornithorhynchus anatinus)
Mammalia EVI2B 36
  • 40 (a)
Species with no ortholog for EVI2B:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for EVI2B Gene

Gene Tree for EVI2B (if available)
Gene Tree for EVI2B (if available)

Paralogs for EVI2B Gene

No data available for Paralogs for EVI2B Gene

Variants for EVI2B Gene

Sequence variations from dbSNP and Humsavar for EVI2B Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type
VAR_056871 -

Structural Variations from Database of Genomic Variants (DGV) for EVI2B Gene

Variant ID Type Subtype PubMed ID
nsv833413 CNV Gain+Loss 17160897

Variation tolerance for EVI2B Gene

Residual Variation Intolerance Score: 61.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.08; 38.11% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for EVI2B Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for EVI2B Gene

Disorders for EVI2B Gene

Relevant External Links for EVI2B

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for EVI2B Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for EVI2B Gene

Publications for EVI2B Gene

  1. cDNA sequence and genomic structure of EVI2B, a gene lying within an intron of the neurofibromatosis type 1 gene. (PMID: 1903357) Cawthon R.M. … White R. (Genomics 1991) 2 3 4 23 67
  2. TAGLN expression is upregulated in NF1-associated malignant peripheral nerve sheath tumors by hypomethylation in its promoter and subpromoter regions. (PMID: 25109740) Park G.H. … Jeong S.Y. (Oncol. Rep. 2014) 3
  3. A whole genome screen for HIV restriction factors. (PMID: 22082156) Liu L. … McKnight A. (Retrovirology 2011) 3
  4. Toward a confocal subcellular atlas of the human proteome. (PMID: 18029348) Barbe L. … Andersson-Svahn H. (Mol. Cell Proteomics 2008) 3
  5. Mutations in RNF135, a gene within the NF1 microdeletion region, cause phenotypic abnormalities including overgrowth. (PMID: 17632510) Douglas J. … Rahman N. (Nat. Genet. 2007) 3

Products for EVI2B Gene

Sources for EVI2B Gene

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