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Aliases for EVI2A Gene

Aliases for EVI2A Gene

  • Ecotropic Viral Integration Site 2A 2 3 5
  • Ecotropic Viral Integration Site 2A Protein Homolog 3 4
  • EVI-2A 3 4
  • EVI2 3 4
  • EVDA 3 4
  • Protein EVI2A 3

External Ids for EVI2A Gene

Previous HGNC Symbols for EVI2A Gene

  • EVI2

Previous GeneCards Identifiers for EVI2A Gene

  • GC17P029666
  • GC17M031551
  • GC17M029494
  • GC17M029790
  • GC17M026668
  • GC17M029644
  • GC17M025854

Summaries for EVI2A Gene

GeneCards Summary for EVI2A Gene

EVI2A (Ecotropic Viral Integration Site 2A) is a Protein Coding gene. GO annotations related to this gene include transmembrane signaling receptor activity. An important paralog of this gene is ENSG00000265118.

UniProtKB/Swiss-Prot for EVI2A Gene

  • May complex with itself or/and other proteins within the membrane, to function as part of a cell-surface receptor.

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for EVI2A Gene

Genomics for EVI2A Gene

Regulatory Elements for EVI2A Gene

Enhancers for EVI2A Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH17G031306 1.7 FANTOM5 ENCODE dbSUPER 13.2 +11.1 11064 9.5 HDGF PKNOX1 CREB3L1 ARNT SIN3A FEZF1 ZNF2 YY1 ZNF766 ZNF143 EVI2A OMG RAB11FIP4 CRLF3 EVI2B ADAP2
GH17G031267 1.2 Ensembl ENCODE 11.8 +52.8 52812 3.3 HDGF ZNF133 ZFP64 SIN3A FEZF1 ZBTB7B GATA2 ZNF143 FOS ZNF263 OMG EVI2A NF1 RAB11FIP4 LOC101927057 GC17P031255 GC17P031253 GC17P031252
GH17G031486 1.7 FANTOM5 ENCODE dbSUPER 7.6 -169.9 -169875 10.5 HDGF PKNOX1 FOXA2 ARID4B SIN3A DMAP1 ZNF2 ZNF143 ZNF207 FOS RAB11FIP4 EVI2B ENSG00000266490 LRRC37B LOC105371722 SUZ12P1 EVI2A SUZ12 GC17P031509 RN7SL79P
GH17G031315 1.2 ENCODE dbSUPER 9.8 +2.5 2463 7.3 PKNOX1 SIN3A CBX5 ZNF143 FOS ZNF202 JUNB ZNF623 TBX21 ZNF518A SUZ12 UTP6 SMURF2P1 ENSG00000266490 LRRC37BP1 SUZ12P1 TBC1D29 SH3GL1P2 EVI2A OMG
GH17G031273 1 Ensembl ENCODE 11.7 +47.3 47326 1.7 ELF3 SOX13 FOXA2 MAX CEBPG FEZF1 ZNF644 YY1 ZNF664 ZNF26 UTP6 OMG SUZ12 EVI2A NF1 TEFM ATAD5 LOC101927057 GC17P031252 GC17P031253
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around EVI2A on UCSC Golden Path with GeneCards custom track

Promoters for EVI2A Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000283046 1584 3001 CTCF TBP PKNOX1 MXI1 SIN3A MAX CEBPG ZBTB40 ZNF664 GATA3

Genomic Location for EVI2A Gene

Chromosome:
17
Start:
31,316,410 bp from pter
End:
31,321,884 bp from pter
Size:
5,475 bases
Orientation:
Minus strand

Genomic View for EVI2A Gene

Genes around EVI2A on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
EVI2A Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for EVI2A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for EVI2A Gene

Proteins for EVI2A Gene

  • Protein details for EVI2A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P22794-EVI2A_HUMAN
    Recommended name:
    Protein EVI2A
    Protein Accession:
    P22794
    Secondary Accessions:
    • B2R5X2
    • B4DHX8

    Protein attributes for EVI2A Gene

    Size:
    236 amino acids
    Molecular mass:
    26213 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAA52413.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAG35269.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for EVI2A Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for EVI2A Gene

Post-translational modifications for EVI2A Gene

  • Glycosylation at Asn31, isoforms=238, Asn49, Asn73, and Asn112
  • Modification sites at PhosphoSitePlus

Other Protein References for EVI2A Gene

No data available for DME Specific Peptides for EVI2A Gene

Domains & Families for EVI2A Gene

Protein Domains for EVI2A Gene

Suggested Antigen Peptide Sequences for EVI2A Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P22794

UniProtKB/Swiss-Prot:

EVI2A_HUMAN :
  • Belongs to the EVI2A family.
Family:
  • Belongs to the EVI2A family.
genes like me logo Genes that share domains with EVI2A: view

No data available for Gene Families for EVI2A Gene

Function for EVI2A Gene

Molecular function for EVI2A Gene

GENATLAS Biochemistry:
murine myeloid leukemia associated gene (Evi-2) homolog A (embedded in NF1 first intron in opposite orientation)
UniProtKB/Swiss-Prot Function:
May complex with itself or/and other proteins within the membrane, to function as part of a cell-surface receptor.

Gene Ontology (GO) - Molecular Function for EVI2A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004888 transmembrane signaling receptor activity NAS 2117566
genes like me logo Genes that share ontologies with EVI2A: view

Phenotypes for EVI2A Gene

GenomeRNAi human phenotypes for EVI2A:
genes like me logo Genes that share phenotypes with EVI2A: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for EVI2A Gene

Localization for EVI2A Gene

Subcellular locations from UniProtKB/Swiss-Prot for EVI2A Gene

Membrane; Single-pass type I membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for EVI2A gene
Compartment Confidence
plasma membrane 3
extracellular 2
mitochondrion 1
endoplasmic reticulum 1

Gene Ontology (GO) - Cellular Components for EVI2A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with EVI2A: view

Pathways & Interactions for EVI2A Gene

SuperPathways for EVI2A Gene

No Data Available

Gene Ontology (GO) - Biological Process for EVI2A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction IEA --
genes like me logo Genes that share ontologies with EVI2A: view

No data available for Pathways by source and SIGNOR curated interactions for EVI2A Gene

Drugs & Compounds for EVI2A Gene

No Compound Related Data Available

Transcripts for EVI2A Gene

mRNA/cDNA for EVI2A Gene

Unigene Clusters for EVI2A Gene

Ecotropic viral integration site 2A:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for EVI2A Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b
SP1: -
SP2: - -
SP3: -

Relevant External Links for EVI2A Gene

GeneLoc Exon Structure for
EVI2A
ECgene alternative splicing isoforms for
EVI2A

Expression for EVI2A Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for EVI2A Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for EVI2A Gene

This gene is overexpressed in Brain - Spinal cord (cervical c-1) (x9.6), Whole Blood (x6.6), Brain - Substantia nigra (x5.6), and Brain - Hippocampus (x4.7).

Protein differential expression in normal tissues from HIPED for EVI2A Gene

This gene is overexpressed in Frontal cortex (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for EVI2A Gene



Protein tissue co-expression partners for EVI2A Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of EVI2A Gene:

EVI2A

SOURCE GeneReport for Unigene cluster for EVI2A Gene:

Hs.591198

Evidence on tissue expression from TISSUES for EVI2A Gene

  • Nervous system(4.8)
  • Pancreas(4.2)
  • Blood(2)
genes like me logo Genes that share expression patterns with EVI2A: view

Primer Products

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for EVI2A Gene

Orthologs for EVI2A Gene

This gene was present in the common ancestor of chordates.

Orthologs for EVI2A Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia -- 35
  • 100 (a)
OneToMany
EVI2A 34
  • 99.61 (n)
cow
(Bos Taurus)
Mammalia EVI2A 34 35
  • 89.62 (n)
dog
(Canis familiaris)
Mammalia EVI2A 34
  • 85.96 (n)
-- 35
  • 74 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Evi2a 34
  • 79.09 (n)
mouse
(Mus musculus)
Mammalia Evi2a 34 16 35
  • 76.82 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 57 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia -- 35
  • 55 (a)
OneToMany
chicken
(Gallus gallus)
Aves EVI2A 34 35
  • 54.82 (n)
lizard
(Anolis carolinensis)
Reptilia -- 35
  • 37 (a)
OneToMany
Species where no ortholog for EVI2A was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for EVI2A Gene

ENSEMBL:
Gene Tree for EVI2A (if available)
TreeFam:
Gene Tree for EVI2A (if available)

Paralogs for EVI2A Gene

Paralogs for EVI2A Gene

genes like me logo Genes that share paralogs with EVI2A: view

Variants for EVI2A Gene

Sequence variations from dbSNP and Humsavar for EVI2A Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type
rs1000103404 -- 31,322,694(+) AACTT(C/T)ATTTT intron-variant, upstream-variant-2KB
rs1000328636 -- 31,321,720(+) AAAAA(A/G)AAAAA intron-variant, utr-variant-5-prime
rs1000345069 -- 31,316,512(+) TTTTA(C/T)GATGA intron-variant, utr-variant-3-prime
rs1000666845 -- 31,317,234(+) AGTCT(C/G)TCAAA intron-variant, utr-variant-3-prime
rs1000699680 -- 31,316,884(+) TAATA(C/G)CTAGA intron-variant, utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for EVI2A Gene

Variant ID Type Subtype PubMed ID
dgv5520n54 CNV loss 21841781
nsv1061870 CNV loss 25217958
nsv574671 CNV gain 21841781
nsv833413 CNV gain+loss 17160897
nsv953876 CNV duplication 24416366

Variation tolerance for EVI2A Gene

Residual Variation Intolerance Score: 74.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.21; 24.30% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for EVI2A Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
EVI2A

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for EVI2A Gene

Disorders for EVI2A Gene

Relevant External Links for EVI2A

Tumor Gene Database (TGDB):
EVI2A
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
EVI2A

No disorders were found for EVI2A Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for EVI2A Gene

Publications for EVI2A Gene

  1. Identification and characterization of transcripts from the neurofibromatosis 1 region: the sequence and genomic structure of EVI2 and mapping of other transcripts. (PMID: 2117566) Cawthon R.M. … White R. (Genomics 1990) 2 3 4 64
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  3. cDNA sequence and genomic structure of EVI2B, a gene lying within an intron of the neurofibromatosis type 1 gene. (PMID: 1903357) Cawthon R.M. … White R. (Genomics 1991) 3 22 64
  4. The human homolog of murine Evi-2 lies between two von Recklinghausen neurofibromatosis translocations. (PMID: 2117565) O'Connell P. … Wallace M. (Genomics 1990) 3 22 64
  5. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3 64

Products for EVI2A Gene

Sources for EVI2A Gene

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