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Aliases for EVI2A Gene

Aliases for EVI2A Gene

  • Ecotropic Viral Integration Site 2A 2 3 5
  • Ecotropic Viral Integration Site 2A Protein Homolog 3 4
  • EVI-2A 3 4
  • EVI2 3 4
  • EVDA 3 4

External Ids for EVI2A Gene

Previous HGNC Symbols for EVI2A Gene

  • EVI2

Previous GeneCards Identifiers for EVI2A Gene

  • GC17P029666
  • GC17M031551
  • GC17M029494
  • GC17M029790
  • GC17M026668
  • GC17M029644
  • GC17M025854

Summaries for EVI2A Gene

GeneCards Summary for EVI2A Gene

EVI2A (Ecotropic Viral Integration Site 2A) is a Protein Coding gene. GO annotations related to this gene include transmembrane signaling receptor activity. An important paralog of this gene is ENSG00000265118.

UniProtKB/Swiss-Prot for EVI2A Gene

  • May complex with itself or/and other proteins within the membrane, to function as part of a cell-surface receptor.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for EVI2A Gene

Genomics for EVI2A Gene

Regulatory Elements for EVI2A Gene

Enhancers for EVI2A Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around EVI2A on UCSC Golden Path with GeneCards custom track

Promoters for EVI2A Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around EVI2A on UCSC Golden Path with GeneCards custom track

Genomic Location for EVI2A Gene

31,316,410 bp from pter
31,321,884 bp from pter
5,475 bases
Minus strand

Genomic View for EVI2A Gene

Genes around EVI2A on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
EVI2A Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for EVI2A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for EVI2A Gene

Proteins for EVI2A Gene

  • Protein details for EVI2A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein EVI2A
    Protein Accession:
    Secondary Accessions:
    • B2R5X2
    • B4DHX8

    Protein attributes for EVI2A Gene

    236 amino acids
    Molecular mass:
    26213 Da
    Quaternary structure:
    No Data Available
    • Sequence=AAA52413.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAG35269.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for EVI2A Gene


neXtProt entry for EVI2A Gene

Proteomics data for EVI2A Gene at MOPED

Post-translational modifications for EVI2A Gene

  • Glycosylation at Asn 31, Asn 38, Asn 49, Asn 73, and Asn 112
  • Modification sites at PhosphoSitePlus

Other Protein References for EVI2A Gene

No data available for DME Specific Peptides for EVI2A Gene

Domains & Families for EVI2A Gene

Protein Domains for EVI2A Gene

Suggested Antigen Peptide Sequences for EVI2A Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the EVI2A family.
  • Belongs to the EVI2A family.
genes like me logo Genes that share domains with EVI2A: view

No data available for Gene Families for EVI2A Gene

Function for EVI2A Gene

Molecular function for EVI2A Gene

GENATLAS Biochemistry:
murine myeloid leukemia associated gene (Evi-2) homolog A (embedded in NF1 first intron in opposite orientation)
UniProtKB/Swiss-Prot Function:
May complex with itself or/and other proteins within the membrane, to function as part of a cell-surface receptor.

Phenotypes for EVI2A Gene

GenomeRNAi human phenotypes for EVI2A:
genes like me logo Genes that share phenotypes with EVI2A: view

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for EVI2A Gene

Localization for EVI2A Gene

Subcellular locations from UniProtKB/Swiss-Prot for EVI2A Gene

Membrane; Single-pass type I membrane protein.

Subcellular locations from

Jensen Localization Image for EVI2A Gene COMPARTMENTS Subcellular localization image for EVI2A gene
Compartment Confidence
plasma membrane 3
extracellular 2
endoplasmic reticulum 1
mitochondrion 1

No data available for Gene Ontology (GO) - Cellular Components for EVI2A Gene

Pathways & Interactions for EVI2A Gene

SuperPathways for EVI2A Gene

No Data Available

Interacting Proteins for EVI2A Gene

STRING Interaction Network Preview (showing 4 interactants - click image to see details)
Selected Interacting proteins: ENSP00000247270 for EVI2A Gene via STRING

Gene Ontology (GO) - Biological Process for EVI2A Gene


No data available for Pathways by source and SIGNOR curated interactions for EVI2A Gene

Drugs & Compounds for EVI2A Gene

No Compound Related Data Available

Transcripts for EVI2A Gene

mRNA/cDNA for EVI2A Gene

Unigene Clusters for EVI2A Gene

Ecotropic viral integration site 2A:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for EVI2A Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b
SP1: -
SP2: - -
SP3: -

Relevant External Links for EVI2A Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for EVI2A Gene

mRNA expression in normal human tissues for EVI2A Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for EVI2A Gene

This gene is overexpressed in Brain - Spinal cord (cervical c-1) (x9.6), Whole Blood (x6.6), Brain - Substantia nigra (x5.6), and Brain - Hippocampus (x4.7).

Protein differential expression in normal tissues from HIPED for EVI2A Gene

This gene is overexpressed in Frontal cortex (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for EVI2A Gene

SOURCE GeneReport for Unigene cluster for EVI2A Gene Hs.591198

genes like me logo Genes that share expression patterns with EVI2A: view

Protein tissue co-expression partners for EVI2A Gene

- Elite partner

Primer Products

No data available for mRNA Expression by UniProt/SwissProt for EVI2A Gene

Orthologs for EVI2A Gene

This gene was present in the common ancestor of chordates.

Orthologs for EVI2A Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia EVI2A 35
  • 89.62 (n)
  • 81.14 (a)
EVI2A 36
  • 79 (a)
(Canis familiaris)
Mammalia EVI2A 35
  • 85.96 (n)
  • 75 (a)
-- 36
  • 74 (a)
(Mus musculus)
Mammalia Evi2a 35
  • 76.82 (n)
  • 66.36 (a)
Evi2a 16
Evi2a 36
  • 65 (a)
(Pan troglodytes)
Mammalia EVI2A 35
  • 99.61 (n)
  • 99.61 (a)
-- 36
  • 100 (a)
(Rattus norvegicus)
Mammalia Evi2a 35
  • 79.09 (n)
  • 69.55 (a)
(Monodelphis domestica)
Mammalia -- 36
  • 55 (a)
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 57 (a)
(Gallus gallus)
Aves EVI2A 35
  • 54.82 (n)
  • 42.18 (a)
EVI2A 36
  • 33 (a)
(Anolis carolinensis)
Reptilia -- 36
  • 37 (a)
Species with no ortholog for EVI2A:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for EVI2A Gene

Gene Tree for EVI2A (if available)
Gene Tree for EVI2A (if available)

Paralogs for EVI2A Gene

Paralogs for EVI2A Gene

genes like me logo Genes that share paralogs with EVI2A: view

Variants for EVI2A Gene

Structural Variations from Database of Genomic Variants (DGV) for EVI2A Gene

Variant ID Type Subtype PubMed ID
nsv833413 CNV Gain+Loss 17160897

Variation tolerance for EVI2A Gene

Residual Variation Intolerance Score: 74.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.21; 24.30% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations from dbSNP and Humsavar and Relevant External Links for EVI2A Gene

Disorders for EVI2A Gene

Relevant External Links for EVI2A

Tumor Gene Database (TGDB):
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for EVI2A Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for EVI2A Gene

Publications for EVI2A Gene

  1. Identification and characterization of transcripts from the neurofibromatosis 1 region: the sequence and genomic structure of EVI2 and mapping of other transcripts. (PMID: 2117566) Cawthon R.M. … White R. (Genomics 1990) 2 3 4 67
  2. cDNA sequence and genomic structure of EVI2B, a gene lying within an intron of the neurofibromatosis type 1 gene. (PMID: 1903357) Cawthon R.M. … White R. (Genomics 1991) 3 23
  3. The human homolog of murine Evi-2 lies between two von Recklinghausen neurofibromatosis translocations. (PMID: 2117565) O'Connell P. … Wallace M. (Genomics 1990) 3 23
  4. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  5. TAGLN expression is upregulated in NF1-associated malignant peripheral nerve sheath tumors by hypomethylation in its promoter and subpromoter regions. (PMID: 25109740) Park G.H. … Jeong S.Y. (Oncol. Rep. 2014) 3

Products for EVI2A Gene

Sources for EVI2A Gene