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Aliases for EVI2A Gene

Aliases for EVI2A Gene

  • Ecotropic Viral Integration Site 2A 2 3 5
  • Ecotropic Viral Integration Site 2A Protein Homolog 3 4
  • EVI-2A 3 4
  • EVI2 3 4
  • EVDA 3 4
  • Protein EVI2A 3

External Ids for EVI2A Gene

Previous HGNC Symbols for EVI2A Gene

  • EVI2

Previous GeneCards Identifiers for EVI2A Gene

  • GC17P029666
  • GC17M031551
  • GC17M029494
  • GC17M029790
  • GC17M026668
  • GC17M029644
  • GC17M025854

Summaries for EVI2A Gene

GeneCards Summary for EVI2A Gene

EVI2A (Ecotropic Viral Integration Site 2A) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include transmembrane signaling receptor activity. An important paralog of this gene is ENSG00000265118.

UniProtKB/Swiss-Prot for EVI2A Gene

  • May complex with itself or/and other proteins within the membrane, to function as part of a cell-surface receptor.

Additional gene information for EVI2A Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for EVI2A Gene

Genomics for EVI2A Gene

GeneHancer (GH) Regulatory Elements for EVI2A Gene

Promoters and enhancers for EVI2A Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH17I031315 Promoter/Enhancer 2 EPDnew Ensembl ENCODE dbSUPER 559.8 +2.5 2463 7.3 PKNOX1 ZSCAN4 BATF ZBTB40 ZNF335 ZNF143 ATF7 FOS IKZF2 RUNX3 EVI2A ENSG00000265118 OMG NF1
GH17I031306 Promoter/Enhancer 2.4 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 13.2 +11.1 11063 9.5 HDGF PKNOX1 ARNT TCF12 ZNF766 ARID2 FOS RUNX3 JUNB NCOA1 EVI2B EVI2A OMG RAB11FIP4 CRLF3 ADAP2 ENSG00000265118 NF1
GH17I031486 Promoter/Enhancer 2.5 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 7.6 -169.9 -169874 10.5 HDGF PKNOX1 FOXA2 ARID4B SIN3A DMAP1 ZNF2 IRF4 POLR2B ZNF207 RAB11FIP4 EVI2B ENSG00000266490 LOC105371722 LRRC37B EVI2A SUZ12 GC17P031509 RN7SL79P
GH17I031267 Enhancer 1 Ensembl ENCODE 11.8 +52.8 52811 3.3 FEZF1 RFX5 ZEB1 SCRT2 RCOR1 FOS USF2 CEBPB SP1 MAFF OMG EVI2A NF1 RAB11FIP4 LOC101927057 GC17P031252 GC17P031253 GC17P031255
GH17I031273 Enhancer 1 Ensembl ENCODE 11.7 +47.3 47325 1.7 ELF3 SOX13 FOXA2 MAX CEBPG FEZF1 ZNF644 YY1 ZNF664 POLR2A LOC101927057 UTP6 GOSR1 OMG SUZ12 EVI2A NF1 TEFM ATAD5 GC17P031252
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around EVI2A on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the EVI2A gene promoter:

Genomic Locations for EVI2A Gene

Genomic Locations for EVI2A Gene
5,475 bases
Minus strand

Genomic View for EVI2A Gene

Genes around EVI2A on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
EVI2A Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for EVI2A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for EVI2A Gene

Proteins for EVI2A Gene

  • Protein details for EVI2A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein EVI2A
    Protein Accession:
    Secondary Accessions:
    • B2R5X2
    • B4DHX8

    Protein attributes for EVI2A Gene

    236 amino acids
    Molecular mass:
    26213 Da
    Quaternary structure:
    No Data Available
    • Sequence=AAA52413.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAG35269.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for EVI2A Gene


neXtProt entry for EVI2A Gene

Post-translational modifications for EVI2A Gene

  • Glycosylation at posLast=3131, Asn38, posLast=4949, posLast=7373, and posLast=112112

Other Protein References for EVI2A Gene

No data available for DME Specific Peptides for EVI2A Gene

Domains & Families for EVI2A Gene

Gene Families for EVI2A Gene

Human Protein Atlas (HPA):
  • Predicted membrane proteins

Protein Domains for EVI2A Gene

Suggested Antigen Peptide Sequences for EVI2A Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the EVI2A family.
  • Belongs to the EVI2A family.
genes like me logo Genes that share domains with EVI2A: view

Function for EVI2A Gene

Molecular function for EVI2A Gene

GENATLAS Biochemistry:
murine myeloid leukemia associated gene (Evi-2) homolog A (embedded in NF1 first intron in opposite orientation)
UniProtKB/Swiss-Prot Function:
May complex with itself or/and other proteins within the membrane, to function as part of a cell-surface receptor.

Gene Ontology (GO) - Molecular Function for EVI2A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004888 transmembrane signaling receptor activity NAS 2117566
genes like me logo Genes that share ontologies with EVI2A: view

Phenotypes for EVI2A Gene

GenomeRNAi human phenotypes for EVI2A:
genes like me logo Genes that share phenotypes with EVI2A: view

Animal Model Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for EVI2A Gene

Localization for EVI2A Gene

Subcellular locations from UniProtKB/Swiss-Prot for EVI2A Gene

Membrane; Single-pass type I membrane protein.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for EVI2A gene
Compartment Confidence
plasma membrane 3
extracellular 2
mitochondrion 1
endoplasmic reticulum 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nuclear bodies (2)
  • Nucleoplasm (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for EVI2A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with EVI2A: view

Pathways & Interactions for EVI2A Gene

SuperPathways for EVI2A Gene

No Data Available

Gene Ontology (GO) - Biological Process for EVI2A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction IEA --
genes like me logo Genes that share ontologies with EVI2A: view

No data available for Pathways by source and SIGNOR curated interactions for EVI2A Gene

Drugs & Compounds for EVI2A Gene

No Compound Related Data Available

Transcripts for EVI2A Gene

mRNA/cDNA for EVI2A Gene

Unigene Clusters for EVI2A Gene

Ecotropic viral integration site 2A:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for EVI2A Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b
SP1: -
SP2: - -
SP3: -

Relevant External Links for EVI2A Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for EVI2A Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for EVI2A Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for EVI2A Gene

This gene is overexpressed in Brain - Spinal cord (cervical c-1) (x9.6), Whole Blood (x6.6), Brain - Substantia nigra (x5.6), and Brain - Hippocampus (x4.7).

Protein differential expression in normal tissues from HIPED for EVI2A Gene

This gene is overexpressed in Frontal cortex (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for EVI2A Gene

Protein tissue co-expression partners for EVI2A Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of EVI2A Gene:


SOURCE GeneReport for Unigene cluster for EVI2A Gene:


Evidence on tissue expression from TISSUES for EVI2A Gene

  • Nervous system(4.8)
  • Pancreas(4.2)
  • Blood(2)
genes like me logo Genes that share expression patterns with EVI2A: view

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for EVI2A Gene

Orthologs for EVI2A Gene

This gene was present in the common ancestor of chordates.

Orthologs for EVI2A Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia -- 34
  • 100 (a)
EVI2A 33
  • 99.61 (n)
(Bos Taurus)
Mammalia EVI2A 33 34
  • 89.62 (n)
(Canis familiaris)
Mammalia EVI2A 33
  • 85.96 (n)
-- 34
  • 74 (a)
(Rattus norvegicus)
Mammalia Evi2a 33
  • 79.09 (n)
(Mus musculus)
Mammalia Evi2a 33 16 34
  • 76.82 (n)
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 57 (a)
(Monodelphis domestica)
Mammalia -- 34
  • 55 (a)
(Gallus gallus)
Aves EVI2A 33 34
  • 54.82 (n)
(Anolis carolinensis)
Reptilia -- 34
  • 37 (a)
Species where no ortholog for EVI2A was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for EVI2A Gene

Gene Tree for EVI2A (if available)
Gene Tree for EVI2A (if available)

Paralogs for EVI2A Gene

Paralogs for EVI2A Gene

genes like me logo Genes that share paralogs with EVI2A: view

Variants for EVI2A Gene

Sequence variations from dbSNP and Humsavar for EVI2A Gene

SNP ID Clin Chr 17 pos Variation AA Info Type
rs144746834 likely-benign, not provided 31,318,976(-) T/C coding_sequence_variant, missense_variant
rs144778786 likely-benign, not provided 31,318,487(-) T/C coding_sequence_variant, missense_variant
rs1129506 benign, not specified 31,319,014(-) G/A/C 5_prime_UTR_variant, coding_sequence_variant, missense_variant, synonymous_variant
rs1000103404 -- 31,322,694(-) T/C upstream_transcript_variant
rs1000328636 -- 31,321,720(-) A/G 5_prime_UTR_variant

Structural Variations from Database of Genomic Variants (DGV) for EVI2A Gene

Variant ID Type Subtype PubMed ID
dgv5520n54 CNV loss 21841781
nsv1061870 CNV loss 25217958
nsv574671 CNV gain 21841781
nsv833413 CNV gain+loss 17160897
nsv953876 CNV duplication 24416366

Variation tolerance for EVI2A Gene

Residual Variation Intolerance Score: 74.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.21; 24.30% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for EVI2A Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for EVI2A Gene

Disorders for EVI2A Gene

Additional Disease Information for EVI2A

No disorders were found for EVI2A Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for EVI2A Gene

Publications for EVI2A Gene

  1. Identification and characterization of transcripts from the neurofibromatosis 1 region: the sequence and genomic structure of EVI2 and mapping of other transcripts. (PMID: 2117566) Cawthon RM … White R (Genomics 1990) 2 3 4 58
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  3. cDNA sequence and genomic structure of EV12B, a gene lying within an intron of the neurofibromatosis type 1 gene. (PMID: 1903357) Cawthon RM … Culver M (Genomics 1991) 3 22 58
  4. The human homolog of murine Evi-2 lies between two von Recklinghausen neurofibromatosis translocations. (PMID: 2117565) O'Connell P … Wallace M (Genomics 1990) 3 22 58
  5. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58

Products for EVI2A Gene

Sources for EVI2A Gene

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