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EVI1 Gene

protein-coding GIFtS: 63

GC03M170283

ecotropic viral integration site 1
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
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Aliases
AML1-EVI-1 ^²
EVI-1 ^², ³
MDS1-EVI1 ^¹, ²
MGC163392 ^²
PRDM3 ^¹, ²

Descriptions
AML1-EVI-1 fusion protein ^²
ecotropic viral integration site 1 ^²
oncogene EVI1 ^²

External Ids
HGNC: 3498¹
Entrez Gene: 2122²
UniProtKB: Q03112³
Ensembl: ENSG00000085276⁷

Search outside databases for aliases for EVI1 gene

Previous GC identifers: GC03M166070 GC03M169855 GC03M170204 GC03M170123 GC03M170122

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Gene Wiki entry for EVI1

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
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Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the EVI1 gene

Entrez Gene cytogenetic band: 3q24-q28 Ensembl cytogenetic band: 3q26.2 HGNC cytogenetic band: 3q26

EVI1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 3 GeneLoc Exon Structure

GeneLoc location for GC03M170283: (about GC identifiers)

Start:	170,283,981 bp from pter
End:	170,348,216 bp from pter
Size:	64,236 bases
Orientation:	minus strand

RefSeq DNA sequence:

NC_000003.10 NT_005612.15

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
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UniProtKB/Swiss-Prot: EVI1_HUMAN, Q03112 (See protein sequence)

Recommended Name: Ecotropic virus integration site 1 protein homolog

Size: 1051 amino acids; 118276 Da

Subunit: May interact with CTBP1 (By similarity)

Subcellular location: Nucleus

Secondary accessions: Q16122 Q99917

Alternative splicing: 2 isoforms: Q03112-1 Q03112-2

Post-translational modifications:

Phosphorylated upon DNA damage, probably by ATM or ATR¹

View phosphorylation sites using PhosphoSite²

REFSEQ proteins (3 alternative transcripts):

NP_001098547.2 NP_001098548.2 NP_005232.2

ENSEMBL proteins:

ENSP00000264674 ENSP00000376494 ENSP00000376493

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Browse Purified and Recombinant Proteins at Millipore
	Browse Human Recombinant Proteins at Sigma-Aldrich
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Recombinant Proteins from Abcam (EVI1)
	Human Recombinant Proteins from Abnova (EVI1)

Browse Origene for full length recombinant human proteins expressed in human HEK293 cells

2 Gene Ontology (GO) cellular component terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005622	intracellular	IEA	--
GO:0005634	nucleus	NAS	--

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Antibodies for EVI1:

	Browse Antibodies Central at Invitrogen
	Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	Sigma-Aldrich Antibodies for EVI1
	Browse R&D Systems for Antibodies
	Cell Signaling Technology (CST) Antibodies for EVI1 (Evi-1)
	Antibodies from Abcam (EVI1), each with their Abpromise^SM
	Monoclonal and Polyclonal Antibodies from Abnova (EVI1)
	Novus Biologicals Antibodies for EVI1

Assays for EVI1:

	Browse Invitrogen for biochemical assays
	Browse Kits and Assays available from Millipore
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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Graphical View of Domain Structure for InterPro Entry Q03112

ProtoNet protein and cluster: Q03112

1 Blocks protein family: IPB007086 C2H2-type zinc finger signature

UniProtKB/Swiss-Prot: EVI1_HUMAN, Q03112

Similarity: Contains 10 C2H2-type zinc fingers

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (EVI1)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (EVI1)

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 3): NM_005241

Applied Biosystems Silencer® siRNAs for EVI1

Sigma-Aldrich siRNA for EVI1

Sigma-Aldrich shRNA for EVI1

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Browse Clone Ranger at Invitrogen for clones
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clones in CMV expression vector (see all 3): NM_001105077
Myc/DDK tagged cDNA clones in CMV expression vector (see all 3): NM_001105077
untagged cDNA clones in CMV expression vector (see all 4): AF164155

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_001105077

Genatlas biochemistry entry for EVI1:

murine ecotropic virus integration site-1,normally expressed in kidney and in developing

oocyte,inappropriately activated by chromosomal rearrangement,leading to expression in

hematopoietic cells and to myeloid leukemias

14 MGI mutant phenotypes (inferred from 2 alleles) (MGI details for Evi1):

	craniofacial	embryogenesis	growth/size	hearing/vestibular/ear
hematopoietic system	immune system	lethality-prenatal/perinatal	limbs/digits/tail	liver/biliary system
muscle	nervous system	reproductive system	respiratory system

5 Gene Ontology (GO) molecular function terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0003674	molecular_function	ND	--
GO:0003677	DNA binding	IEA	--
GO:0005515	protein binding	IPI	11328817 17635584
GO:0008270	zinc ion binding	IEA	--
GO:0046872	metal ion binding	IEA	--

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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1 Sigma-Aldrich "Your Favorite Gene" Pathway for EVI1 (Your Favorite Gene powered by Ingenuity)

Chronic Myeloid Leukemia Signaling

GeneDecks EVI1 for the pathways selected above

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Gene Network Central^TM Interacting Genes and Proteins Network for EVI1

5/33 Interacting proteins for EVI1 (Q03112¹ ENSP00000264674³) via UniProtKB, MINT, and/or STRING (see all 33 )

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
UXT	Q9UBK9¹, ENSP00000337393³	EBI-1384862, EBI-357355 STRING (score=.793)
Ctbp2 Ctbp2 (xeno)	P56546¹	EBI-1384862, EBI-1384883
CTBP1	ENSP00000372411³	STRING (score=.998)
RUNX1	ENSP00000300305³	STRING (score=.988)
HDAC1	ENSP00000362649³	STRING (score=.986)

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2 Gene Ontology (GO) biological process terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0007275	multicellular organismal development	IEA	--
GO:0008150	biological_process	ND	--

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(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences

Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for EVI1
1 Novoseek chemical compound relationship for EVI1 gene

Compound	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
zinc	34.78	3	10867128 (2), 8921366 (1)

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(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
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Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (EVI1)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (EVI1)

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 3): NM_005241

Sigma-Aldrich siRNA for EVI1

Sigma-Aldrich shRNA for EVI1

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_001105077 NM_001105078 NM_005241

REFSEQ mRNAs for EVI1 gene (3 alternative transcripts):

NM_001105077.2 NM_001105078.2 NM_005241.2

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_001105077 NM_001105078 NM_005241

               OriGene GFP tagged cDNA clones in CMV expression vector (see all 3): NM_001105077
                                 Myc/DDK tagged cDNA clones in CMV expression vector (see all 3): NM_001105077
                                 untagged cDNA clones in CMV expression vector (see all 4): AF164155

Additional cDNA sequence:

AF164154.1 AF164155.1 AF164156.1 AF164157.1 AF487422.1 AF487423.1 AF487424.1 AK025934.1

AK292865.1 AK304098.1 AK308404.1 AK310509.1 BC012450.1 BC031019.1 BC130520.1 BC143951.1

BC143952.1 BX640908.1 BX647613.1 X54989.1

15 DOTS entries:

DT.97833454 DT.95188434 DT.112836 DT.97783385 DT.95365072 DT.120888100 DT.65286979 DT.120888089

DT.91692286 DT.95228866 DT.75173055 DT.97814361 DT.112839 DT.97767208 DT.75165091

24/120 AceView cDNA sequences (see all 120 ):

AA961157 AA236533 AL699361 AF487422 BC012450 AI079954 AW851143 BM984772

AI587511 AA335780 BM768941 AI808322 CB132738 BQ102518 BC031019 AA335418

AK025934 AA913663 BX482681 AA335020 AA132806 BU741968 BX280183 BX647613

highest scoring ESTs for EVI1:

AA044205 AF164155 AF164157 AF487424 AL699157 AL699287 AL699361 AL699457 BX470726 BX475994

Unigene Cluster for EVI1:

Ecotropic viral integration site 1

Hs.719216 [show with all ESTs]

Unigene Representative Sequence: BX640908

GeneLoc Exon Structure

5/10 Alternative Splicing Database (ASD) splice patterns (SP) for EVI1 (see all 10 )

ExUns:	1	^	2a	·	2b	·	2c	^	3a	·	3b	·	3c	^	4	^	5	^	6	^	7	^	8a	·	8b	·	8c	^	9a	·	9b	·	9c	^	10a	·	10b	^	11	^	12a	·	12b	^	13	^	14	^	15	^	16	^
SP1:													-				-		-
SP2:																																															-
SP3:																			-
SP4:			-		-		-		-		-		-				-		-
SP5:							-		-		-		-				-		-

ExUns:	17	^	18	^	19	^	20	^	21
SP1:
SP2:
SP3:
SP4:
SP5:

About this scheme

ECgene alternative splicing isoforms for EVI1

3 Ensembl transcripts including schematic representations:

ENST00000264674 ENST00000392737 ENST00000392736

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
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EVI1 expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for EVI1

¹ / ² / ³

11 probe-sets matching EVI1 gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
1881_at²^{, 3}	U95-A	1	1.00	1.00	0.91	0.68	HG4058-HT4328	0.20	1.00	0.72	1
1882_g_at²^{, 3}	U95-A	1	1.00	1.00	0.99	0.90	HG4058-HT4328	0.20	1.00	0.72	1
46205_at²^{, 3}	U95-B	1	1.00	1.00	0.88	1.35	AA044205	0.80	0.88	0.84	1
32399_at²^{, 3}	U95-A	1	1.00	1.00	0.59	0.31	S82592	0.80	0.88	0.84	1
59145_at²^{, 3}	U95-C	1	0.69	1.00	0.48	1.18	AI279399	0.60	0.83	0.73	1
226420_at²^{, 3}	U133-B	1	1.00	1.00	--	--	BG261252	0.60	0.83	0.73	1
221884_at²^{, 3}	U133-A	1	1.00	1.00	--	--	BE466525	0.60	0.83	0.73	1
215851_at²^{, 3}	U133-A	1	1.00	1.00	--	--	S82592	0.80	0.88	0.84	1
226420_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
221884_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
215851_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--

GeneDecks EVI1 for binary patterns associated with the probe-sets selected above

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Data from

(Publications) and GNF BioGPS
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About these images

CGAP SAGE TAG: --

SOURCE GeneReport for Unigene cluster: Hs.719216
Expression variation in blood from EXPOLDB for EVI1

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
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Orthologs for EVI1 gene from 5/9 species (see all 9 )

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	EVI1¹	--	ecotropic viral integration site 1	95.11(n) 96.99(a)	488148 XM_545272.2 XP_545272.2
chimpanzee (Pan troglodytes)	EVI1¹	--	ecotropic viral integration site 1	99.76(n) 99.91(a)	460837 XM_516864.2 XP_516864.2
cow (Bos taurus)	EVI1¹	--	ecotropic viral integration site 1	94.25(n) 97.09(a)	532209 XM_610719.3 XP_610719.3
rat (Rattus norvegicus)	Evi1¹	--	ecotropic viral integration site 1	88.76(n) 92.81(a)	294924 XM_226987.4 XP_226987.4
mouse (Mus musculus)	Evi1^{1, 5}	3 (14.40 cM)⁵	ecotropic viral integration site 1^{1, 5}	91.05(n)¹ 93.51(a)¹	14013¹ NM_007963.1¹ NP_031989.1¹ AJ001482⁵ AK033517⁵ (see all 11)

About this table Species with no ortholog for EVI1

ENSEMBL Gene Tree for EVI1

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
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Paralogs for EVI1 gene

PRDM13² PRDM16²

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
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10/467 NCBI SNPs in EVI1 are shown (see all 467 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 199)

AB	SNP ID	Valid	Chr 3 pos	Sequence	Recs	AA Chg	Type	More	Recs	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--			--
	rs6796432^1,2	A,C,F,H	170349814(+)	`GTAGGA/CAAACA`	1	--	ng3¹		7	EU EA WA NA	560
	rs1048604^1,2	A,C,F,H	170284189(-)	`AGAGAG/TAAGTA`	3	--	ut3¹ trp³		6	EA MN EU WA	2078
	rs10936575^1,2	A,C,F,H	170347845(+)	`GCCGCT/CGGGTT`	3	--	ut5¹ ng3¹ ese³		11	NA EU EA WA	978
	rs1420476^1,2	C,F,H,O	170347244(-)	`TGTGAT/ATGCCT`	3	--	ng3¹ ut5¹ ese³		8	MN NA EU EA WA	744
	rs2306281^1,2	C,F,H	170349600(+)	`TGGACC/TGGCTC`	1	--	ng3¹		13	EA NA EU WA	2534
	rs7633965^1,2	C,F,H	170347337(+)	`CATTTC/AGAGAT`	3	--	ng3¹ ut5¹		8	EU EA WA	840
	rs3821384^1,2	C,F	170283758(-)	`GCACCA/GCAACC`	3	--	ng5¹		5	EA NA	1708
	rs13321289^1,2	C,F	170283637(+)	`ATAATG/AAAAAA`	3	--	ng5¹		3	NA	140
	rs1420477^1,2	F,H	170346969(-)	`GGTCGT/GCCGGC`	3	--	ng3¹ int¹		4	EU EA WA	396
	rs2127299^1,2	H	170285268(+)	`CACTAG/AACTTT`	3	--	ut3¹ ese³		5	EA EU WA	460

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HapMap Linkage Disequilibrium images for EVI1 (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
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OMIM: 165215

UniProtKB/Swiss-Prot: EVI1_HUMAN, Q03112

A chromosomal aberration involving EVI1 is a cause of chronic myelogenous leukemia (CML).

Translocation t(3;21)(q26;q22) with RUNX1/AML1

10/16 Novoseek disease relationships for EVI1 gene (see all 16 )

Disease	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
myeloid leukemia	70.70	6	8700545 (1), 17913523 (1), 10867128 (1), 12972028 (1) (see all 6)
myelodysplastic syndromes	69.71	11	11243114 (2), 11721451 (2), 8700545 (1), 17409414 (1) (see all 6)
leukemogenesis	66.19	2	12972028 (1), 16014322 (1)
blast crisis	60.98	3	18613965 (2), 7808006 (1)
hematopoietic malignancies	60.59	1	11069022 (1)
leukemia	58.47	19	9183665 (4), 7808006 (2), 10867128 (2), 16156860 (1) (see all 12)
myeloid leukemia chronic	44.13	3	7808006 (2)
monosomy	37.90	1	12139729 (1)
chromosomal aberrations	34.79	4	8700545 (1), 18619962 (1), 14704036 (1), 17243162 (1)
minimal residual disease	33.77	2	11248334 (1), 17693194 (1)

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Genatlas disease: EVI1

myelodysplastic syndrome,related to therapy,acute myeloid or undifferentiated leukemia,blastic

crisis in CML with inversion inv3(q21;q26), translocations

t(3;3)(q21;q26),t(3;12)(q26;p13),t(3;21)(q26;q22),der 3t(3;78) and others (see also

MDS1,EAP,ETV6,GR6,AML1,RPN1,TCRBV@)

Tumor Gene Database: EVI1

(Possibly Related Articles in Doctor's Guide)
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Trisenox (Arsenic Trioxide) Yielding Promising Results in Treatment of Multiple Myeloma and Myelodysplastic Syndrome

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
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10/85 PubMed articles for EVI1 gene (see all 85 ):

Unique expression of the human Evi-1 gene in an endometrial carcinoma cell line: sequence of cDNAs and structure of alternatively spliced transcripts. (PubMed id 2115646)^{2, 3, 4} Morishita K....Ihle J.N. (1990)
Structurally altered Evi-1 protein generated in the 3q21q26 syndrome. (PubMed id 8700545)^{1, 3, 4} Ogawa S.... Hirai H. (1996)
Intergenic splicing of MDS1 and EVI1 occurs in normal tissues as well as in myeloid leukemia and produces a new member of the PR domain family. (PubMed id 8643684)^{2, 3} Fears S....Nucifora G. (1996)
Generation of the AML1-EVI-1 fusion gene in the t(3;21)(q26;q22) causes blastic crisis in chronic myelocytic leukemia. (PubMed id 8313895)^{3, 4} Mitani K.... Hirai H. (1994)
EVI1 is expressed in megakaryocyte cell lineage and enforced expression of EVI1 in UT-7/GM cells induces megakaryocyte differentiation. (PubMed id 11922610)^{1, 3} Shimizu S....Morishita K. (2002)
Repression of bone morphogenetic protein and activin-inducible transcription by Evi-1. (PubMed id 15849193)^{1, 3} Alliston T....Derynck R. (2005)
High EVI1 expression predicts poor survival in acute myeloid leukemia: a study of 319 de novo AML patients. (PubMed id 12393383)^{1, 3} Barjesteh van Waalwijk van Doorn-Khosrovani S....Delwel R. (2003)
EVI1 promotes cell proliferation by interacting with BRG1 and blocking the repression of BRG1 on E2F1 activity. (PubMed id 14555651)^{1, 3} Chi Y....Nucifora G. (2003)
A novel interaction between the proto-oncogene Evi1 and histone methyltransferases, SUV39H1 and G9a. (PubMed id 18619962)^{1, 3} Spensberger D. and Delwel R. (2008)
Amplification and translocation of 3q26 with overexpression of EVI1 in Fanconi anemia-derived childhood acute myeloid leukemia with biallelic FANCD1/BRCA2 disruption. (PubMed id 17243162)^{1, 3} Meyer S....Tonnies H. (2007)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
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Entrez Gene: 2122	HGNC: 3498	AceView: EVI1	Ensembl:ENSG00000085276	euGenes: HUgn2122
ECgene: EVI1	H-InvDB: EVI1

(According to HUGE)
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(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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Name	Description
ATLAS Chromosomes in Cancer entry for EVI1	Genetics and Cytogenetics in Oncology and Haematology

Licensable Technologies for EVI1
(Available from WIS Yeda, Salk, Tufts)

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(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
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Products for EVI1:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for EVI1-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for EVI1		Antibodies for EVI1
	Explore super-pooled esiRNAs		Browse proteins at Sigma-Aldrich
	Lentivirus-delivered shRNAs for EVI1		Browse small molecules at Sigma-Aldrich
	"Your Favorite Gene" Pathways		feedback

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Antibodies & Assays for EVI1 (Evi-1)

	Recombinant Proteins (EVI1)
	Antibodies (EVI1)

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Antibodies for EVI1

GeneCards Homepage - Last full update: 2 Jul 2009 Incremental update: 13 Oct 2009

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Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

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EVI1 Gene at Home site.
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EVI1 Gene

protein-coding GIFtS: 63

Aliases &
Descriptions
for EVI1

Summaries
for EVI1

Genomic Location
for EVI1

Proteins
for EVI1

Protein Domains/
Families
for EVI1

Gene Function
for EVI1

Pathways & Interactions
for EVI1

Drugs & Compounds
for EVI1

Transcripts
for EVI1

Expression
for EVI1

Orthologs
for EVI1

Paralogs
for EVI1

SNPs/Variants
for EVI1

Disorders & Mutations
for EVI1

Medical News
for EVI1

Publications
for EVI1

Search for EVI1

Genome Databases showing EVI1

Other Databases showing EVI1

Specialized Databases showing EVI1

Licensable Technologies
for EVI1

Services
for EVI1

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

EVI1 Gene

protein-coding GIFtS: 63

Aliases & Descriptionsfor EVI1

Summariesfor EVI1

Genomic Locationfor EVI1

Proteinsfor EVI1

Protein Domains/Familiesfor EVI1

Gene Functionfor EVI1

Pathways & Interactionsfor EVI1

Drugs & Compoundsfor EVI1

Transcriptsfor EVI1

Expression for EVI1

Orthologsfor EVI1

Paralogsfor EVI1

SNPs/Variantsfor EVI1

Disorders & Mutationsfor EVI1

Medical Newsfor EVI1

Publicationsfor EVI1

Search for EVI1

Genome Databases showing EVI1

Other Databases showing EVI1

Specialized Databases showing EVI1

Licensable Technologiesfor EVI1

Servicesfor EVI1

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for EVI1

Summaries
for EVI1

Genomic Location
for EVI1

Proteins
for EVI1

Protein Domains/
Families
for EVI1

Gene Function
for EVI1

Pathways & Interactions
for EVI1

Drugs & Compounds
for EVI1

Transcripts
for EVI1

Expression
for EVI1

Orthologs
for EVI1

Paralogs
for EVI1

SNPs/Variants
for EVI1

Disorders & Mutations
for EVI1

Medical News
for EVI1

Publications
for EVI1

Licensable Technologies
for EVI1

Services
for EVI1