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EVC Gene

protein-coding   GIFtS: 48
GCID: GC04P005712

Ellis Van Creveld Syndrome

  See EVC-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Ellis Van Creveld Syndrome1 2
DWF-12 3
EVC12
EVCL2
Ellis-Van Creveld Syndrome Protein2

External Ids:    HGNC: 34971   Entrez Gene: 21212   Ensembl: ENSG000000728407   OMIM: 6048315   UniProtKB: P576793   

Export aliases for EVC gene to outside databases

Previous GC identifers: GC04P005587 GC04M005935 GC04P005705 GC04P005777 GC04P005830


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for EVC Gene:
This gene encodes a protein containing a leucine zipper and a transmembrane domain. This gene has been implicated
in both Ellis-van Creveld syndrome (EvC) and Weyers acrodental dysostosis. (provided by RefSeq, Jul 2008)

GeneCards Summary for EVC Gene:
EVC (Ellis van Creveld syndrome) is a protein-coding gene. Diseases associated with EVC include weyers acrofacial dysostosis, and evc-related ellis-van creveld syndrome.

UniProtKB/Swiss-Prot: EVC_HUMAN, P57679
Function: Acts as a positive mediator of Hedgehog signaling indispensable for normal endochondral growth and
skeletal development (By similarity)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000004.11  NT_006051.19  NC_018915.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the EVC gene promoter:
         Elk-1   GATA-3   MEF-2   MIF-1   AP-4   Egr-4   Evi-1   MEF-2A   SEF-1 (1)   aMEF-2   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search Chromatin IP Primers for EVC

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat EVC


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 4p16   Ensembl cytogenetic band:  4p16.2   HGNC cytogenetic band: 4p16

EVC Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
EVC gene location

GeneLoc information about chromosome 4         GeneLoc Exon Structure

GeneLoc location for GC04P005712:  view genomic region     (about GC identifiers)

Start:
5,712,924 bp from pter      End:
5,830,772 bp from pter
Size:
117,849 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: EVC_HUMAN, P57679 (See protein sequence)
Recommended Name: Ellis-van Creveld syndrome protein  
Size: 992 amino acids; 111990 Da
Subunit: Interacts with EVC2 (By similarity)

Explore the universe of human proteins at neXtProt for EVC: NX_P57679

Explore proteomics data for EVC at MOPED


See EVC Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

REFSEQ proteins: NP_714928.1  
ENSEMBL proteins: 
 ENSP00000264956   ENSP00000426774   ENSP00000372120  

EVC Human Recombinant Protein Products:

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OriGene Purified Protein for EVC
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Cloud-Clone Corp. Proteins for EVC

 
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antibodies-online proteins for EVC (4 products) 

 
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EVC Antibody Products:

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EVC Assay Products:

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Cloud-Clone Corp. CLIAs for EVC
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antibodies-online kits for EVC (3 products) 


(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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2 InterPro protein domains:
 IPR026501 Limbin/Ellis-van_Creveld
 IPR026582 Evc

Graphical View of Domain Structure for InterPro Entry P57679

ProtoNet protein and cluster: P57679


Find genes that share domains with EVC           About GenesLikeMe


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Molecular Function:

     UniProtKB/Swiss-Prot Summary: EVC_HUMAN, P57679
Function: Acts as a positive mediator of Hedgehog signaling indispensable for normal endochondral growth and
skeletal development (By similarity)

     Gene Ontology (GO): 1 molecular function term:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005515protein binding ----
     
Find genes that share ontologies with EVC           About GenesLikeMe


Phenotypes:
     8 MGI mutant phenotypes (inferred from 1 allele(MGI details for Evc):
 behavior/neurological  cellular  craniofacial  growth/size/body  limbs/digits/tail 
 mortality/aging  reproductive system  skeleton 

Find genes that share phenotypes with EVC           About GenesLikeMe

Animal Models:
   genOway: Develop your customized and physiologically relevant rodent model for EVC

miRNA
Products:
    
miRTarBase miRNAs that target EVC:
hsa-mir-339-5p (MIRT042772), hsa-mir-335-5p (MIRT018424), hsa-mir-455-3p (MIRT037807)

Block miRNA regulation of human, mouse, rat EVC using miScript Target Protectors
1 qRT-PCR Assays for microRNA that regulate EVC:
hsa-miR-3658
SwitchGear 3'UTR luciferase reporter plasmidEVC 3' UTR sequence
Inhib. RNA
Products:
    
OriGene RNAi products in human, mouse, rat for EVC
Predesigned siRNA for gene silencing in human, mouse, rat EVC

Gene Editing
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DNA2.0 Custom Protein Engineering Service for EVC

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OriGene clones in human, mouse for EVC (see all 7)
OriGene ORF clones in mouse, rat for EVC
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
GenScript: all cDNA clones in your preferred vector: EVC (NM_153717)
Browse Sino Biological Human cDNA Clones
DNA2.0 Custom Codon Optimized Gene Synthesis Service for EVC
Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat EVC

Cell Line
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GenScript Custom overexpressing Cell Line Services for EVC
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In Situ Assay
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Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for EVC


(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Subcellular locations from UniProtKB/Swiss-Prot
EVC_HUMAN, P57679: Cell membrane; Single-pass membrane protein (By similarity). Cytoplasm, cytoskeleton, cilium
basal body (By similarity). Cell projection, cilium (By similarity). Cell projection, cilium membrane (By
similarity). Note=EVC2 is required for the localization of EVC at the base of primary cilia (By similarity)
Subcellular locations from COMPARTMENTS: 

CompartmentConfidence
plasma membrane5
cytoskeleton4
cytosol3
nucleus3

Gene Ontology (GO): 5 cellular component terms:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005737cytoplasm IEA--
GO:0005929cilium IDA--
GO:0016021integral component of membrane IEA--
GO:0036064ciliary basal body ISS--
GO:0060170ciliary membrane IEA--

Find genes that share ontologies with EVC           About GenesLikeMe


(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for EVC
Interactions:

    GeneGlobe Interaction Network for EVC

Gene Ontology (GO): Selected biological process terms (see all 6):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0001501skeletal system development TAS10700184
GO:0003416endochondral bone growth ISS--
GO:0007224smoothened signaling pathway IEA--
GO:0007517muscle organ development TAS10700184
GO:0045880positive regulation of smoothened signaling pathway ISS--

Find genes that share ontologies with EVC           About GenesLikeMe



(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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Browse Small Molecules at EMD Millipore
   Browse drugs & compounds from Enzo Life Sciences
  Browse compounds at ApexBio 

Browse Tocris compounds for EVC



(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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REFSEQ mRNAs for EVC gene (2 alternative transcripts): 
NM_153717.2  NM_014556.2  

Unigene Cluster for EVC:

Ellis van Creveld syndrome
Hs.646899  [show with all ESTs]
Unigene Representative Sequence: AF216185
6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
ENST00000264956(uc003gil.1) ENST00000509451 ENST00000514919 ENST00000506240
ENST00000515113 ENST00000382674(uc003gim.1)
miRNA
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Block miRNA regulation of human, mouse, rat EVC using miScript Target Protectors
1 qRT-PCR Assays for microRNA that regulate EVC:
hsa-miR-3658
SwitchGear 3'UTR luciferase reporter plasmidEVC 3' UTR sequence
Inhib. RNA
Products:
     
OriGene RNAi products in human, mouse, rat for EVC
Predesigned siRNA for gene silencing in human, mouse, rat EVC
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OriGene ORF clones in mouse, rat for EVC
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
GenScript: all cDNA clones in your preferred vector: EVC (NM_153717)
DNA2.0 Custom Codon Optimized Gene Synthesis Service for EVC
Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat EVC
Primer
Products:
    
OriGene qSTAR qPCR primer pairs in human, mouse for EVC
Pre-validated RT2 qPCR Primer Assay in human, mouse, rat EVC
  QuantiTect SYBR Green Assays in human, mouse, rat EVC
  QuantiFast Probe-based Assays in human, mouse, rat EVC

Additional mRNA sequence: 

AF216185.1 AF239742.1 AK025394.1 BC085608.1 

8 DOTS entries:

DT.91783263  DT.91783246  DT.92047587  DT.100715473  DT.100715472  DT.100737231  DT.92353232  DT.203977 

Selected AceView cDNA sequences (see all 158):

AF216185 BF329760 BE384172 AF216184 NM_014556 AI559994 BF823735 AF239742 
BF329701 NM_153717 BF359426 AI336116 BM989103 AI565778 BF329762 BF329744 
AA496722 BF329743 BU182800 BI763178 CN482170 AA599216 BQ710431 BF329751 

GeneLoc Exon Structure


(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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EVC expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: GCAAAAGTGA
EVC Expression
About this image

EVC Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

EVC Protein Expression

SOURCE GeneReport for Unigene cluster: Hs.646899

UniProtKB/Swiss-Prot: EVC_HUMAN, P57679
Tissue specificity: Found in the developing vertebral bodies, ribs, upper and lower limbs, heart, kidney, lung

    Custom PCR Arrays for EVC
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Pre-validated RT2 qPCR Primer Assay in human, mouse, rat EVC
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QuantiFast Probe-based Assays in human, mouse, rat EVC
In Situ
Assay Products:
 

 
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for EVC

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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This gene was present in the common ancestor of chordates.

Orthologs for EVC gene from Selected species (see all 9)    About this table
Organism Taxonomic
classification
Gene Description Human
Similarity
Orthology
Type
Details
mouse
(Mus musculus)
Mammalia Evc1 , 5 Ellis van Creveld gene homolog (human)5
Ellis van Creveld gene syndrome1
75.83(n)1
68.36(a)1
  5 (20.06 cM)5
590561  NM_021292.21  NP_067267.21 
 372890985 
chicken
(Gallus gallus)
Aves EVC1 Ellis van Creveld syndrome 60.04(n)
50.94(a)
  422851  NM_001005347.2  NP_001005347.1 
tropical clawed frog
(Xenopus tropicalis)
Amphibia evc1 Ellis van Creveld syndrome 57.01(n)
45.08(a)
  100124788  NM_001102764.1  NP_001096234.1 


ENSEMBL Gene Tree for EVC (if available)
TreeFam Gene Tree for EVC (if available)

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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Selected SNPs for EVC (see all 3164)    About this table                                 

Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance
Chr 4 posSequence#AA
Chg
TypeMore#Allele
freq
PopTotal
sample
More
----------
rs359536261,2,,4
C,FEllis-van Creveld syndrome (EVC)4 pathogenic15733157(-) TGCCTA/C/G/
        
GCTGG
2 Q R mis114NA NS EA WA CSA EU 6353
VAR_0099444
Acrofacial dysostosis, Weyers type (WAD)4--see VAR_0099442 S P mis40--------
VAR_0664484
Ellis-van Creveld syndrome (EVC)4--see VAR_0664482 L P mis40--------
VAR_0664474
Ellis-van Creveld syndrome (EVC)4--see VAR_0664472 S N mis40--------
rs1219084241,2
Cpathogenic15788072(+) AGCAGC/TAGCAG 2 Q * stg10--------
rs1396140351,2
C--5669457(+) AGTCT-/GGCGGGT
TCACACACCA
GGCCT
1 -- int10--------
rs58558911,2
C--5684415(-) ACTCT-/AGTCAG 1 -- int11Minor allele frequency- A:0.50NA 2
rs1505004091,2
C--5685626(+) GCCTC-/AGGGAA 1 -- int10--------
rs1442361671,2
--5685816(+) ACCCAC/TCCATC 1 -- int10--------
rs1161379271,2
C,F--5685831(+) CACCCG/ATCCAC 1 -- int11Minor allele frequency- A:0.06NA 120

HapMap Linkage Disequilibrium report for EVC (5712924 - 5830772 bp)

Structural Variations
     Database of Genomic Variants (DGV) Selected variations for EVC (see all 15):    About this table    
Variant IDTypeSubtypePubMed ID
esv1097941CNV Deletion17803354
esv2726976CNV Deletion23290073
esv991561CNV Deletion20482838
esv2726977CNV Deletion23290073
esv1296377CNV Insertion17803354
nsv508993CNV Insertion20534489
esv21689CNV Loss19812545
dgv314n21CNV Loss19592680
nsv517345CNV Loss19592680
nsv461182CNV Loss19166990

Human Gene Mutation Database (HGMD): EVC
Site Specific Mutation Identification with PCR Assays
SeqTarget long-range PCR primers for resequencing EVC
DNA2.0 Custom Variant and Variant Library Synthesis for EVC

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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OMIM gene information: 604831   
OMIM disorders: 225500  193530  
UniProtKB/Swiss-Prot: EVC_HUMAN, P57679
  • Ellis-van Creveld syndrome (EVC) [MIM:225500]: An autosomal recessive condition characterized by the
    clinical tetrad of chondrodystrophy, polydactyly, ectodermal dysplasia and cardiac anomalies. Patients manifest
    short-limb dwarfism, short ribs, postaxial polydactyly, and dysplastic nails and teeth. Congenital heart defects,
    most commonly an atrioventricular septal defect, are observed in 60% of affected individuals. Note=The disease is
    caused by mutations affecting the gene represented in this entry
  • Acrofacial dysostosis, Weyers type (WAD) [MIM:193530]: An autosomal dominant condition characterized by
    dysplastic nails, postaxial polydactyly, dental anomalies, short limbs, short stature and normal intelligence.
    The phenotype is milder than Ellis-van Creveld syndrome. Note=The disease is caused by mutations affecting the
    gene represented in this entry

  • 6 diseases for EVC:    
    About MalaCards
    weyers acrofacial dysostosis    evc-related ellis-van creveld syndrome    ellis-van creveld syndrome    dysostosis
    sensenbrenner syndrome    asphyxiating thoracic dystrophy

    6 diseases from the University of Copenhagen DISEASES database for EVC:
    Ellis-Van Creveld syndrome     Polydactyly     Asphyxiating thoracic dystrophy     Dysostosis
    Congenital heart defect     Sensenbrenner syndrome

    Find genes that share disorders with EVC           About GenesLikeMe

    5 Novoseek inferred disease relationships for EVC gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    ellis-van creveld syndrome 98.1 9 17024374 (2), 10700184 (1), 19251731 (1), 17392984 (1) (see all 8)
    polydactyly, postaxial 93.3 2 10700184 (1), 17392984 (1)
    dysostosis 83.5 3 10700184 (3)
    short stature 57.8 1 10700184 (1)
    heart defects congenital 40.7 2 10700184 (1), 17392984 (1)

    Genetic Association Database (GAD): EVC
    Human Genome Epidemiology (HuGE) Navigator: EVC (7 documents)

    Export disorders for EVC gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for EVC gene, integrated from 10 sources (see all 30):
    (articles sorted by number of sources associating them with EVC)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Mutations in a new gene in Ellis-van Creveld syndrome and Weyers acrodental dysostosis. (PubMed id 10700184)1, 2, 3, 9 Ruiz-Perez V.L....Goodship J. (Nat. Genet. 2000)
    2. Extending the spectrum of Ellis van Creveld syndrome: a large family with a mild mutation in the EVC gene. (PubMed id 18947413)1, 2, 9 Ulucan H....Biesecker L.G. (BMC Med. Genet. 2008)
    3. Common variations in 4p locus are related to male completed suicide. (PubMed id 19115052)1, 4, 9 Must A....VAoli M. (Neuromolecular Med. 2009)
    4. A genome-wide search for loci interacting with known prostate cancer risk-associated genetic variants. (PubMed id 22219177)1, 4 Tao S....Sun J. (Carcinogenesis 2012)
    5. A novel missense mutation in the EVC gene underlies Ellis-van Creveld syndrome in a Pakistani family. (PubMed id 19744229)1, 2 Kalsoom U.-E.... Ahmad W. (Pediatr. Int. 2010)
    6. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (Mol. Med. 2010)
    7. Maternal genes and facial clefts in offspring: a comprehensive search for genetic associations in two population-based cleft studies from Scandinavia. (PubMed id 20634891)1, 4 Jugessur A....Murray J.C. (PLoS ONE 2010)
    8. Association between genes on chromosome 4p16 and non-syndromic oral clefts in four populations. (PubMed id 20087401)1, 4 Ingersoll R.G....Beaty T.H. (Eur. J. Hum. Genet. 2010)
    9. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1, 4 Bailey S.D....Anand S. (Diabetes Care 2010)
    10. Haplotype and linkage disequilibrium analysis of the CRMP1 and EVC genes. (PubMed id 15492864)1, 9 Sivakumaran T.A. and Lesperance M.M. (Int. J. Mol. Med. 2004)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 2121 HGNC: 3497 AceView: EVC Ensembl:ENSG00000072840 euGenes: HUgn2121
    ECgene: EVC H-InvDB: EVC

    (According to HUGE)
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    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for EVC Pharmacogenomics, SNPs, Pathways
    GeneReviewshttp://www.ncbi.nlm.nih.gov/books/NBK1116/?term=EVC[genesymbol]

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for EVC gene:
    Search GeneIP for patents involving EVC

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from genOway)
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