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Aliases for EVA1C Gene

Aliases for EVA1C Gene

  • Eva-1 Homolog C (C. Elegans) 2 3
  • Family With Sequence Similarity 176, Member C 2 3
  • Protein FAM176C 3 4
  • C21orf63 3 4
  • C21orf64 3 4
  • FAM176C 3 4
  • SUE21 3 4
  • Chromosome 21 Open Reading Frame 64 2
  • Chromosome 21 Open Reading Frame 63 2
  • Protein Eva-1 Homolog C 3
  • PRED34 3
  • B19 3
  • B18 3

External Ids for EVA1C Gene

Previous HGNC Symbols for EVA1C Gene

  • C21orf64
  • C21orf63
  • FAM176C

Previous GeneCards Identifiers for EVA1C Gene

  • GC21P033786

Summaries for EVA1C Gene

GeneCards Summary for EVA1C Gene

EVA1C (Eva-1 Homolog C (C. Elegans)) is a Protein Coding gene. GO annotations related to this gene include carbohydrate binding. An important paralog of this gene is EVA1A.

UniProtKB/Swiss-Prot for EVA1C Gene

  • Binds heparin.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for EVA1C Gene

Genomics for EVA1C Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for EVA1C Gene

Start:
32,411,723 bp from pter
End:
32,515,400 bp from pter
Size:
103,678 bases
Orientation:
Plus strand

Genomic View for EVA1C Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for EVA1C Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for EVA1C Gene

No data available for Regulatory Elements for EVA1C Gene

Proteins for EVA1C Gene

  • Protein details for EVA1C Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P58658-EVA1C_HUMAN
    Recommended name:
    Protein eva-1 homolog C
    Protein Accession:
    P58658
    Secondary Accessions:
    • A6ND58
    • Q8IXZ0

    Protein attributes for EVA1C Gene

    Size:
    441 amino acids
    Molecular mass:
    49483 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for EVA1C Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for EVA1C Gene

Proteomics data for EVA1C Gene at MOPED

Post-translational modifications for EVA1C Gene

  • Glycosylation at Asn62 and Asn165
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for EVA1C Gene

Domains for EVA1C Gene

Protein Domains for EVA1C Gene

Graphical View of Domain Structure for InterPro Entry

P58658

UniProtKB/Swiss-Prot:

EVA1C_HUMAN :
  • P58658
Domain:
  • Contains 2 SUEL-type lectin domains.
Family:
  • Belongs to the EVA1 family.
genes like me logo Genes that share domains with EVA1C: view

No data available for Gene Families and Suggested Antigen Peptide Sequences for EVA1C Gene

Function for EVA1C Gene

Molecular function for EVA1C Gene

UniProtKB/Swiss-Prot Function: Binds heparin.

Gene Ontology (GO) - Molecular Function for EVA1C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0030246 carbohydrate binding IEA --
genes like me logo Genes that share ontologies with EVA1C: view

Phenotypes for EVA1C Gene

GenomeRNAi human phenotypes for EVA1C:
genes like me logo Genes that share phenotypes with EVA1C: view

Animal Model Products

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for EVA1C Gene

Localization for EVA1C Gene

Subcellular locations from UniProtKB/Swiss-Prot for EVA1C Gene

Membrane; Single-pass type I membrane protein.

Gene Ontology (GO) - Cellular Components for EVA1C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with EVA1C: view

No data available for Subcellular locations from COMPARTMENTS for EVA1C Gene

Pathways for EVA1C Gene

SuperPathways for EVA1C Gene

No Data Available

Interacting Proteins for EVA1C Gene

STRING Interaction Network Preview (showing 2 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000300255%0d%0a9606.ENSP00000317872%0d%0a9606.ENSP00000344818%0d%0a
Selected Interacting proteins: ENSP00000300255 P58658-EVA1C_HUMAN for EVA1C Gene via STRING I2D

Gene Ontology (GO) - Biological Process for EVA1C Gene

None

No data available for Pathways by source for EVA1C Gene

Transcripts for EVA1C Gene

Unigene Clusters for EVA1C Gene

Eva-1 homolog C (C. elegans):
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for EVA1C

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for EVA1C
  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for EVA1C Gene

ExUns: 1a · 1b ^ 2a · 2b · 2c · 2d · 2e ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8a · 8b · 8c · 8d ^ 9a · 9b ^ 10a · 10b
SP1: - -
SP2: - - -
SP3: - - -
SP4: - - - - - -
SP5: - - - - - - -
SP6: - - -
SP7:
SP8: - -
SP9: - - - -

Relevant External Links for EVA1C Gene

GeneLoc Exon Structure for
EVA1C
ECgene alternative splicing isoforms for
EVA1C

Expression for EVA1C Gene

mRNA expression in normal human tissues for EVA1C Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for EVA1C Gene

SOURCE GeneReport for Unigene cluster for EVA1C Gene Hs.208358

mRNA Expression by UniProt/SwissProt for EVA1C Gene

P58658-EVA1C_HUMAN
Tissue specificity: Ubiquitous.
genes like me logo Genes that share expressions with EVA1C: view

In Situ Assay Products

No data available for mRNA differential expression in normal tissues for EVA1C Gene

Orthologs for EVA1C Gene

This gene was present in the common ancestor of animals.

Orthologs for EVA1C Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia EVA1C 35
  • 99.4 (n)
  • 98.87 (a)
EVA1C 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia EVA1C 35
  • 87.91 (n)
  • 88.21 (a)
EVA1C 36
  • 88 (a)
OneToOne
dog
(Canis familiaris)
Mammalia EVA1C 35
  • 90.33 (n)
  • 91.38 (a)
EVA1C 36
  • 91 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Eva1c 35
  • 85.76 (n)
  • 86.36 (a)
Eva1c 16
Eva1c 36
  • 86 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia EVA1C 36
  • 76 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia EVA1C 36
  • 64 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Eva1c 35
  • 85.68 (n)
  • 85.68 (a)
chicken
(Gallus gallus)
Aves EVA1C 36
  • 61 (a)
OneToOne
LOC100857603 35
  • 71.24 (n)
  • 67.61 (a)
lizard
(Anolis carolinensis)
Reptilia EVA1C 36
  • 63 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia eva1c 35
  • 62.34 (n)
  • 56.36 (a)
zebrafish
(Danio rerio)
Actinopterygii ddx41 36
  • 25 (a)
OneToMany
eva1c 35
  • 52.08 (n)
  • 45.25 (a)
eva1c 36
  • 40 (a)
OneToMany
EVA1C (1 of 9) 36
  • 25 (a)
OneToMany
EVA1C (2 of 9) 36
  • 25 (a)
OneToMany
EVA1C (4 of 9) 36
  • 26 (a)
OneToMany
EVA1C (5 of 9) 36
  • 18 (a)
OneToMany
EVA1C (6 of 9) 36
  • 19 (a)
OneToMany
EVA1C (7 of 9) 36
  • 25 (a)
OneToMany
EVA1C (8 of 9) 36
  • 23 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta CG42402 36
  • 13 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea eva-1 36
  • 20 (a)
OneToMany
Species with no ortholog for EVA1C:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for EVA1C Gene

ENSEMBL:
Gene Tree for EVA1C (if available)
TreeFam:
Gene Tree for EVA1C (if available)

Paralogs for EVA1C Gene

Paralogs for EVA1C Gene

Selected SIMAP similar genes for EVA1C Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with EVA1C: view

Variants for EVA1C Gene

Sequence variations from dbSNP and Humsavar for EVA1C Gene

SNP ID Clin Chr 21 pos Sequence Context AA Info Type MAF
rs762173 -- 32,460,367(+) CTGCC(A/G)CCCCT intron-variant
rs762174 -- 32,460,634(+) CAGAT(C/T)ATCCA intron-variant
rs958342 -- 32,493,593(-) CTGTG(C/G)GTGGG intron-variant
rs1041823 -- 32,459,886(+) AACAA(C/T)TGGAG intron-variant
rs1041824 -- 32,459,958(+) GAAAT(A/G)TTTCA intron-variant

Relevant External Links for EVA1C Gene

HapMap Linkage Disequilibrium report
EVA1C

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for EVA1C Gene

Disorders for EVA1C Gene

No disorders were found for EVA1C Gene.

No data available for UniProtKB/Swiss-Prot for EVA1C Gene

Publications for EVA1C Gene

  1. Human C21orf63 is a heparin-binding protein. (PMID: 19470522) Mitsunaga K. … Angata T. (J. Biochem. 2009) 2 3 4
  2. From PREDs and open reading frames to cDNA isolation: revisiting the human chromosome 21 transcription map. (PMID: 11707072) Reymond A. … Antonarakis S.E. (Genomics 2001) 2 3 4
  3. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark H.F. … Gray A.M. (Genome Res. 2003) 3 4
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  5. Violating the splicing rules: TG dinucleotides function as alternative 3' splice sites in U2-dependent introns. (PMID: 17672918) Szafranski K. … Platzer M. (Genome Biol. 2007) 3

Products for EVA1C Gene

Sources for EVA1C Gene

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