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Aliases for EVA1C Gene

Aliases for EVA1C Gene

  • Eva-1 Homolog C 2 3 5
  • Family With Sequence Similarity 176, Member C 2 3
  • Protein FAM176C 3 4
  • C21orf63 3 4
  • C21orf64 3 4
  • FAM176C 3 4
  • SUE21 3 4
  • Chromosome 21 Open Reading Frame 64 2
  • Chromosome 21 Open Reading Frame 63 2
  • Eva-1 Homolog C (C. Elegans) 2
  • Protein Eva-1 Homolog C 3
  • PRED34 3
  • B18 3
  • B19 3

External Ids for EVA1C Gene

Previous HGNC Symbols for EVA1C Gene

  • C21orf64
  • C21orf63
  • FAM176C

Previous GeneCards Identifiers for EVA1C Gene

  • GC21P033786

Summaries for EVA1C Gene

GeneCards Summary for EVA1C Gene

EVA1C (Eva-1 Homolog C) is a Protein Coding gene. GO annotations related to this gene include carbohydrate binding.

UniProtKB/Swiss-Prot for EVA1C Gene

  • Binds heparin.

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for EVA1C Gene

Genomics for EVA1C Gene

Regulatory Elements for EVA1C Gene

Enhancers for EVA1C Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH21G032492 1.4 Ensembl ENCODE dbSUPER 54.8 +83.0 82989 4.6 PKNOX1 ZNF493 ZFP64 FEZF1 ZNF48 GATA2 FOS ZNF202 SP3 REST EVA1C URB1 ENSG00000252045 EXOSC3P1 MIS18A URB1-AS1 PAXBP1-AS1 TCP10L TIAM1 LOC101928078
GH21G032258 1.2 Ensembl ENCODE 53.2 -153.2 -153192 0.6 RB1 ZNF493 ZFP64 RAD21 ZNF354C SCRT2 ZNF143 DEK ZNF202 ZNF654 EVA1C URB1 EXOSC3P1 PAXBP1-AS1 MIS18A-AS1 LINC00846 LOC105372779 HUNK MIS18A ENSG00000261610
GH21G033323 1.4 ENCODE dbSUPER 39.7 +913.5 913485 2.4 CREB3L1 DMAP1 YY1 ZNF416 ZNF143 ZNF548 ZNF263 SP3 PPARGC1A MEF2D EVA1C C21orf62-AS1 EXOSC3P1 IFNAR1 CRYZL1 IFNAR2 RPS5P2 USF1P1
GH21G033201 1.9 FANTOM5 Ensembl ENCODE dbSUPER 24.9 +792.3 792270 4.5 HDGF PKNOX1 SIN3A DMAP1 ZNF48 YY1 FOS ZNF548 MCM3 ZNF662 EVA1C IFNAR2 IFNGR2 MIS18A OLIG2 ENSG00000249624 LINC01548 ENSG00000226433 OLIG1 C21orf62-AS1
GH21G032519 1.9 FANTOM5 Ensembl ENCODE dbSUPER 21.6 +110.6 110640 6.5 ATF1 PKNOX1 SIN3A GLI4 BRCA1 YY1 GATA2 FOS ZNF263 REST EVA1C TCP10L SNORA80A PAXBP1 PIR52370 EXOSC3P1
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around EVA1C on UCSC Golden Path with GeneCards custom track

Promoters for EVA1C Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000300127 708 2001 ATF1 ZNF48 ZNF121 GLIS2 KLF7 ZNF263 SP3 SMARCB1 ZNF579 ZNF610

Genomic Location for EVA1C Gene

32,411,692 bp from pter
32,515,400 bp from pter
103,709 bases
Plus strand

Genomic View for EVA1C Gene

Genes around EVA1C on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
EVA1C Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for EVA1C Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for EVA1C Gene

Proteins for EVA1C Gene

  • Protein details for EVA1C Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein eva-1 homolog C
    Protein Accession:
    Secondary Accessions:
    • A6ND58
    • Q8IXZ0

    Protein attributes for EVA1C Gene

    441 amino acids
    Molecular mass:
    49483 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for EVA1C Gene


neXtProt entry for EVA1C Gene

Post-translational modifications for EVA1C Gene

  • Glycosylation at Asn62 and isoforms=3165
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for EVA1C Gene

Domains & Families for EVA1C Gene

Protein Domains for EVA1C Gene

Suggested Antigen Peptide Sequences for EVA1C Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the EVA1 family.
  • Belongs to the EVA1 family.
genes like me logo Genes that share domains with EVA1C: view

No data available for Gene Families for EVA1C Gene

Function for EVA1C Gene

Molecular function for EVA1C Gene

UniProtKB/Swiss-Prot Function:
Binds heparin.

Gene Ontology (GO) - Molecular Function for EVA1C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0030246 carbohydrate binding IEA --
genes like me logo Genes that share ontologies with EVA1C: view
genes like me logo Genes that share phenotypes with EVA1C: view

Animal Models for EVA1C Gene

MGI Knock Outs for EVA1C:

Animal Model Products

Inhibitory RNA Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for EVA1C Gene

Localization for EVA1C Gene

Subcellular locations from UniProtKB/Swiss-Prot for EVA1C Gene

Membrane; Single-pass type I membrane protein.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for EVA1C gene
Compartment Confidence
nucleus 3
golgi apparatus 2
plasma membrane 1
extracellular 1
cytoskeleton 1
mitochondrion 1
endoplasmic reticulum 1
cytosol 1

Gene Ontology (GO) - Cellular Components for EVA1C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with EVA1C: view

Pathways & Interactions for EVA1C Gene

SuperPathways for EVA1C Gene

No Data Available

Gene Ontology (GO) - Biological Process for EVA1C Gene


No data available for Pathways by source and SIGNOR curated interactions for EVA1C Gene

Drugs & Compounds for EVA1C Gene

No Compound Related Data Available

Transcripts for EVA1C Gene

Unigene Clusters for EVA1C Gene

Eva-1 homolog C (C. elegans):
Representative Sequences:

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for EVA1C Gene

ExUns: 1a · 1b ^ 2a · 2b · 2c · 2d · 2e ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8a · 8b · 8c · 8d ^ 9a · 9b ^ 10a · 10b
SP1: - -
SP2: - - -
SP3: - - -
SP4: - - - - - -
SP5: - - - - - - -
SP6: - - -
SP8: - -
SP9: - - - -

Relevant External Links for EVA1C Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for EVA1C Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for EVA1C Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for EVA1C Gene

This gene is overexpressed in Gallbladder (40.7) and Prostate (21.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for EVA1C Gene

Protein tissue co-expression partners for EVA1C Gene

NURSA nuclear receptor signaling pathways regulating expression of EVA1C Gene:


SOURCE GeneReport for Unigene cluster for EVA1C Gene:


mRNA Expression by UniProt/SwissProt for EVA1C Gene:

Tissue specificity: Ubiquitous.

Evidence on tissue expression from TISSUES for EVA1C Gene

  • Nervous system(4.1)
genes like me logo Genes that share expression patterns with EVA1C: view

Primer Products

No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for EVA1C Gene

Orthologs for EVA1C Gene

This gene was present in the common ancestor of animals.

Orthologs for EVA1C Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia EVA1C 34 35
  • 99.4 (n)
(Canis familiaris)
Mammalia EVA1C 34 35
  • 90.33 (n)
(Bos Taurus)
Mammalia EVA1C 34 35
  • 87.91 (n)
(Mus musculus)
Mammalia Eva1c 34 16 35
  • 85.76 (n)
(Rattus norvegicus)
Mammalia Eva1c 34
  • 85.68 (n)
(Monodelphis domestica)
Mammalia EVA1C 35
  • 76 (a)
(Ornithorhynchus anatinus)
Mammalia EVA1C 35
  • 64 (a)
(Gallus gallus)
Aves LOC100857603 34
  • 71.24 (n)
EVA1C 35
  • 61 (a)
(Anolis carolinensis)
Reptilia EVA1C 35
  • 63 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia eva1c 34
  • 62.34 (n)
(Danio rerio)
Actinopterygii eva1c 34 35
  • 52.08 (n)
EVA1C (4 of 9) 35
  • 26 (a)
ddx41 35
  • 25 (a)
EVA1C (1 of 9) 35
  • 25 (a)
EVA1C (2 of 9) 35
  • 25 (a)
EVA1C (7 of 9) 35
  • 25 (a)
EVA1C (8 of 9) 35
  • 23 (a)
EVA1C (6 of 9) 35
  • 19 (a)
EVA1C (5 of 9) 35
  • 18 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG42402 35
  • 13 (a)
(Caenorhabditis elegans)
Secernentea eva-1 35
  • 20 (a)
Species where no ortholog for EVA1C was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for EVA1C Gene

Gene Tree for EVA1C (if available)
Gene Tree for EVA1C (if available)

Paralogs for EVA1C Gene

(2) SIMAP similar genes for EVA1C Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with EVA1C: view

No data available for Paralogs for EVA1C Gene

Variants for EVA1C Gene

Sequence variations from dbSNP and Humsavar for EVA1C Gene

SNP ID Clin Chr 21 pos Sequence Context AA Info Type
rs1000012484 -- 32,420,207(+) TCTAC(C/T)TAAAA intron-variant
rs1000027786 -- 32,499,484(+) TGATG(A/G)GCATG intron-variant
rs1000029428 -- 32,488,809(+) TCGAA(C/T)TCCTG intron-variant
rs1000070224 -- 32,473,626(+) TCCTC(C/T)GGGCA intron-variant
rs1000073862 -- 32,416,207(+) TGTTT(-/TGTGTG)TGTGT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for EVA1C Gene

Variant ID Type Subtype PubMed ID
esv1162904 CNV insertion 17803354
esv1348711 CNV deletion 17803354
esv2670130 CNV deletion 23128226
esv2723343 CNV deletion 23290073
esv2723344 CNV deletion 23290073
esv2723345 CNV deletion 23290073
esv3419325 CNV insertion 20981092
esv3557643 CNV deletion 23714750
esv3646885 CNV gain 21293372
esv3646886 CNV gain 21293372
esv3893405 CNV gain 25118596
nsv1063676 CNV gain 25217958
nsv1066657 CNV gain 25217958
nsv1126606 CNV deletion 24896259
nsv1142327 CNV tandem duplication 24896259
nsv187017 CNV insertion 16902084
nsv187110 CNV deletion 16902084
nsv187413 CNV deletion 16902084
nsv3494 CNV insertion 18451855
nsv834085 CNV gain 17160897
nsv962671 CNV duplication 23825009
nsv962672 CNV duplication 23825009
nsv962673 CNV duplication 23825009
nsv979532 CNV duplication 23825009

Variation tolerance for EVA1C Gene

Residual Variation Intolerance Score: 86.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.37; 54.02% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for EVA1C Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for EVA1C Gene

Disorders for EVA1C Gene

Relevant External Links for EVA1C

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for EVA1C Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for EVA1C Gene

Publications for EVA1C Gene

  1. Human C21orf63 is a heparin-binding protein. (PMID: 19470522) Mitsunaga K. … Angata T. (J. Biochem. 2009) 2 3 4 64
  2. From PREDs and open reading frames to cDNA isolation: revisiting the human chromosome 21 transcription map. (PMID: 11707072) Reymond A. … Antonarakis S.E. (Genomics 2001) 2 3 4 64
  3. The expression pattern of EVA1C, a novel Slit receptor, is consistent with an axon guidance role in the mouse nervous system. (PMID: 24040182) James G. … Beverdam A. (PLoS ONE 2013) 2 3 64
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  5. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark H.F. … Gray A.M. (Genome Res. 2003) 3 4 64

Products for EVA1C Gene

Sources for EVA1C Gene

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