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Aliases for EVA1A Gene

Aliases for EVA1A Gene

  • Eva-1 Homolog A, Regulator Of Programmed Cell Death 2 3
  • Transmembrane Protein 166 2 3 4
  • Family With Sequence Similarity 176, Member A 2 3
  • Eva-1 Homolog A (C. Elegans) 2 5
  • Protein FAM176A 3 4
  • FAM176A 3 4
  • TMEM166 3 4
  • Eva-1 Homolog A 3

External Ids for EVA1A Gene

Previous HGNC Symbols for EVA1A Gene

  • TMEM166
  • FAM176A

Previous GeneCards Identifiers for EVA1A Gene

  • GC02M075697

Summaries for EVA1A Gene

GeneCards Summary for EVA1A Gene

EVA1A (Eva-1 Homolog A, Regulator Of Programmed Cell Death) is a Protein Coding gene. An important paralog of this gene is EVA1B.

UniProtKB/Swiss-Prot for EVA1A Gene

  • Acts as a regulator of programmed cell death, mediating both autophagy and apoptosis.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for EVA1A Gene

Genomics for EVA1A Gene

Regulatory Elements for EVA1A Gene

Enhancers for EVA1A Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around EVA1A on UCSC Golden Path with GeneCards custom track

Genomic Location for EVA1A Gene

75,469,302 bp from pter
75,569,722 bp from pter
100,421 bases
Minus strand

Genomic View for EVA1A Gene

Genes around EVA1A on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
EVA1A Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for EVA1A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for EVA1A Gene

Proteins for EVA1A Gene

  • Protein details for EVA1A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein eva-1 homolog A
    Protein Accession:
    Secondary Accessions:
    • D6W5J3
    • Q9HC41

    Protein attributes for EVA1A Gene

    152 amino acids
    Molecular mass:
    17470 Da
    Quaternary structure:
    No Data Available

neXtProt entry for EVA1A Gene

Proteomics data for EVA1A Gene at MOPED

Post-translational modifications for EVA1A Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for EVA1A Gene

Domains & Families for EVA1A Gene

Protein Domains for EVA1A Gene


Suggested Antigen Peptide Sequences for EVA1A Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the EVA1 family.
  • Belongs to the EVA1 family.
genes like me logo Genes that share domains with EVA1A: view

No data available for Gene Families for EVA1A Gene

Function for EVA1A Gene

Molecular function for EVA1A Gene

UniProtKB/Swiss-Prot Function:
Acts as a regulator of programmed cell death, mediating both autophagy and apoptosis.
genes like me logo Genes that share phenotypes with EVA1A: view

Animal Model Products

  • Taconic Biosciences Mouse Models for EVA1A

miRNA for EVA1A Gene

miRTarBase miRNAs that target EVA1A

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for EVA1A Gene

Localization for EVA1A Gene

Subcellular locations from UniProtKB/Swiss-Prot for EVA1A Gene

Endoplasmic reticulum membrane; Single-pass membrane protein. Lysosome membrane; Single-pass membrane protein.

Subcellular locations from

Jensen Localization Image for EVA1A Gene COMPARTMENTS Subcellular localization image for EVA1A gene
Compartment Confidence
plasma membrane 5
endoplasmic reticulum 4
lysosome 4
vacuole 4
extracellular 3

Gene Ontology (GO) - Cellular Components for EVA1A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005765 lysosomal membrane IEA --
GO:0005789 endoplasmic reticulum membrane IEA --
GO:0005886 plasma membrane IDA --
genes like me logo Genes that share ontologies with EVA1A: view

Pathways & Interactions for EVA1A Gene

SuperPathways for EVA1A Gene

No Data Available

Interacting Proteins for EVA1A Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
Selected Interacting proteins: Q9H8M9-EVA1A_HUMAN ENSP00000233712 for EVA1A Gene via MINT STRING I2D

Gene Ontology (GO) - Biological Process for EVA1A Gene


No data available for Pathways by source and SIGNOR curated interactions for EVA1A Gene

Drugs & Compounds for EVA1A Gene

No Compound Related Data Available

Transcripts for EVA1A Gene

Unigene Clusters for EVA1A Gene

Eva-1 homolog A (C. elegans):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for EVA1A Gene

ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b · 2c · 2d ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b · 7c ^ 8a · 8b · 8c · 8d · 8e · 8f · 8g · 8h
SP1: - - -
SP2: - - - - - - - -
SP3: - - - -
SP4: - - -
SP5: - - - - - - - -
SP6: - - - - - - - - -
SP7: - - - - - - -
SP8: - - - - -
SP9: -

Relevant External Links for EVA1A Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for EVA1A Gene

mRNA expression in normal human tissues for EVA1A Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for EVA1A Gene

This gene is overexpressed in Liver (x20.0), Pancreas (x6.1), and Kidney - Cortex (x5.7).

Protein differential expression in normal tissues from HIPED for EVA1A Gene

This gene is overexpressed in Bone (54.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MOPED, and MaxQB for EVA1A Gene

SOURCE GeneReport for Unigene cluster for EVA1A Gene Hs.302346

mRNA Expression by UniProt/SwissProt for EVA1A Gene

Tissue specificity: Expressed in lung, kidney, liver, pancreas, placenta, but not in heart and skeletal muscle.
genes like me logo Genes that share expression patterns with EVA1A: view

Protein tissue co-expression partners for EVA1A Gene

Primer Products

Orthologs for EVA1A Gene

This gene was present in the common ancestor of animals.

Orthologs for EVA1A Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia LOC528994 35
  • 84.28 (n)
  • 87.8 (a)
(Canis familiaris)
Mammalia FAM176A 35
  • 88.97 (n)
  • 92.09 (a)
EVA1A 36
  • 92 (a)
(Mus musculus)
Mammalia Eva1a 35
  • 81.46 (n)
  • 81.46 (a)
Eva1a 16
Eva1a 36
  • 85 (a)
(Pan troglodytes)
Mammalia FAM176A 35
  • 99.12 (n)
  • 100 (a)
TMEM166 36
  • 100 (a)
(Rattus norvegicus)
Mammalia Eva1a 35
  • 84.35 (n)
  • 86.39 (a)
(Monodelphis domestica)
Mammalia -- 36
  • 62 (a)
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 31 (a)
(Gallus gallus)
Aves -- 36
  • 71 (a)
(Anolis carolinensis)
Reptilia -- 36
  • 11 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia eva1a 35
  • 70.74 (n)
  • 75.54 (a)
(Danio rerio)
Actinopterygii LOC100331241 35
  • 67.39 (n)
  • 69.78 (a)
eva1ba 36
  • 44 (a)
si:ch211-66i15.5 36
fruit fly
(Drosophila melanogaster)
Insecta CG42402 36
  • 3 (a)
(Caenorhabditis elegans)
Secernentea eva-1 36
  • 7 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
Species with no ortholog for EVA1A:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for EVA1A Gene

Gene Tree for EVA1A (if available)
Gene Tree for EVA1A (if available)

Paralogs for EVA1A Gene

Paralogs for EVA1A Gene

(1) SIMAP similar genes for EVA1A Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with EVA1A: view

Variants for EVA1A Gene

Sequence variations from dbSNP and Humsavar for EVA1A Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type
rs11126472 - 75,493,246(+) AGTAG(C/T)GATTC reference, missense
rs718507 -- 75,556,421(-) TCAGG(A/C)TTGGT intron-variant
rs725774 -- 75,567,647(+) TCTTC(C/G)ATTCA intron-variant
rs759255 -- 75,561,270(-) TGCTG(G/T)CAGGG intron-variant, upstream-variant-2KB
rs917922 -- 75,506,803(-) TTGTG(A/C/T)GGCAG intron-variant

Variation tolerance for EVA1A Gene

Residual Variation Intolerance Score: 76% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.12; 69.23% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Structural Variations from Database of Genomic Variants (DGV) and Relevant External Links for EVA1A Gene

Disorders for EVA1A Gene

Relevant External Links for EVA1A

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for EVA1A Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for EVA1A Gene

Publications for EVA1A Gene

  1. CCAAT/enhancer binding protein I+ predicts poorer prognosis and prevents energy starvation-induced cell death in hepatocellular carcinoma. (PMID: 25363290) Lu G.D. … Hooi S.C. (Hepatology 2015) 2 3 67
  2. Transmembrane protein 166 regulates autophagic and apoptotic activities following focal cerebral ischemic injury in rats. (PMID: 22227058) Li L. … Zhou C. (Exp. Neurol. 2012) 2 3
  3. Adenovirus vector-mediated FAM176A overexpression induces cell death in human H1299 non-small cell lung cancer cells. (PMID: 24257118) Xie H. … Chen Y. (BMB Rep 2014) 3
  4. Expression of TMEM166 protein in human normal and tumor tissues. (PMID: 22495369) Xu D. … Chen Y.Y. (Appl. Immunohistochem. Mol. Morphol. 2013) 3
  5. Genome-wide association study of antiphospholipid antibodies. (PMID: 23509613) Kamboh M.I. … Demirci F.Y. (Autoimmune Dis 2013) 3

Products for EVA1A Gene

Sources for EVA1A Gene