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Aliases for EVA1A Gene

Aliases for EVA1A Gene

  • Eva-1 Homolog A (C. Elegans) 2 3
  • Transmembrane Protein 166 2 3 4
  • Family With Sequence Similarity 176, Member A 2 3
  • Protein FAM176A 3 4
  • FAM176A 3 4
  • TMEM166 3 4
  • Protein Eva-1 Homolog A 3

External Ids for EVA1A Gene

Previous HGNC Symbols for EVA1A Gene

  • TMEM166
  • FAM176A

Previous GeneCards Identifiers for EVA1A Gene

  • GC02M075697

Summaries for EVA1A Gene

GeneCards Summary for EVA1A Gene

EVA1A (Eva-1 Homolog A (C. Elegans)) is a Protein Coding gene. An important paralog of this gene is EVA1C.

UniProtKB/Swiss-Prot for EVA1A Gene

  • Acts as a regulator of programmed cell death, mediating both autophagy and apoptosis.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for EVA1A Gene

Genomics for EVA1A Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for EVA1A Gene

Start:
75,469,302 bp from pter
End:
75,569,722 bp from pter
Size:
100,421 bases
Orientation:
Minus strand

Genomic View for EVA1A Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for EVA1A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for EVA1A Gene

No data available for Regulatory Elements for EVA1A Gene

Proteins for EVA1A Gene

  • Protein details for EVA1A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9H8M9-EVA1A_HUMAN
    Recommended name:
    Protein eva-1 homolog A
    Protein Accession:
    Q9H8M9
    Secondary Accessions:
    • D6W5J3
    • Q9HC41

    Protein attributes for EVA1A Gene

    Size:
    152 amino acids
    Molecular mass:
    17470 Da
    Quaternary structure:
    No Data Available

neXtProt entry for EVA1A Gene

Proteomics data for EVA1A Gene at MOPED

Post-translational modifications for EVA1A Gene

  • Ubiquitination at Lys109
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for EVA1A Gene

Domains for EVA1A Gene

Protein Domains for EVA1A Gene

ProtoNet:

Graphical View of Domain Structure for InterPro Entry

Q9H8M9

UniProtKB/Swiss-Prot:

EVA1A_HUMAN :
  • Q9H8M9
Family:
  • Belongs to the EVA1 family.
genes like me logo Genes that share domains with EVA1A: view

No data available for Gene Families and Suggested Antigen Peptide Sequences for EVA1A Gene

Function for EVA1A Gene

Molecular function for EVA1A Gene

UniProtKB/Swiss-Prot Function: Acts as a regulator of programmed cell death, mediating both autophagy and apoptosis.

Phenotypes for EVA1A Gene

GenomeRNAi human phenotypes for EVA1A:
genes like me logo Genes that share phenotypes with EVA1A: view

Animal Model Products

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for EVA1A Gene

Localization for EVA1A Gene

Subcellular locations from UniProtKB/Swiss-Prot for EVA1A Gene

Endoplasmic reticulum membrane; Single-pass membrane protein. Lysosome membrane; Single-pass membrane protein.

Gene Ontology (GO) - Cellular Components for EVA1A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005764 lysosome --
GO:0005765 lysosomal membrane IEA --
GO:0005783 endoplasmic reticulum --
GO:0005789 endoplasmic reticulum membrane IEA --
GO:0005886 plasma membrane IDA --
genes like me logo Genes that share ontologies with EVA1A: view

No data available for Subcellular locations from COMPARTMENTS for EVA1A Gene

Pathways for EVA1A Gene

SuperPathways for EVA1A Gene

No Data Available

Interacting Proteins for EVA1A Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000233712%0d%0a9606.ENSP00000344818%0d%0a
Selected Interacting proteins: Q9H8M9-EVA1A_HUMAN ENSP00000233712 for EVA1A Gene via MINT STRING I2D

Gene Ontology (GO) - Biological Process for EVA1A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006914 autophagy IEA --
GO:0006915 apoptotic process IEA --
genes like me logo Genes that share ontologies with EVA1A: view

No data available for Pathways by source for EVA1A Gene

Transcripts for EVA1A Gene

Unigene Clusters for EVA1A Gene

Eva-1 homolog A (C. elegans):
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for EVA1A

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for EVA1A Gene

ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b · 2c · 2d ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b · 7c ^ 8a · 8b · 8c · 8d · 8e · 8f · 8g · 8h
SP1: - - -
SP2: - - - - - - - -
SP3: - - - -
SP4: - - -
SP5: - - - - - - - -
SP6: - - - - - - - - -
SP7: - - - - - - -
SP8: - - - - -
SP9: -
SP10:

Relevant External Links for EVA1A Gene

GeneLoc Exon Structure for
EVA1A
ECgene alternative splicing isoforms for
EVA1A

Expression for EVA1A Gene

mRNA expression in normal human tissues for EVA1A Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for EVA1A Gene

This gene is overexpressed in Liver (20.0), Pancreas (6.1), and Kidney - Cortex (5.7).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for EVA1A Gene

SOURCE GeneReport for Unigene cluster for EVA1A Gene Hs.302346

mRNA Expression by UniProt/SwissProt for EVA1A Gene

Q9H8M9-EVA1A_HUMAN
Tissue specificity: Expressed in lung, kidney, liver, pancreas, placenta, but not in heart and skeletal muscle.
genes like me logo Genes that share expressions with EVA1A: view

In Situ Assay Products

Orthologs for EVA1A Gene

This gene was present in the common ancestor of animals.

Orthologs for EVA1A Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia FAM176A 35
  • 99.12 (n)
  • 100 (a)
TMEM166 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia LOC528994 35
  • 84.28 (n)
  • 87.8 (a)
dog
(Canis familiaris)
Mammalia EVA1A 36
  • 92 (a)
OneToOne
FAM176A 35
  • 88.97 (n)
  • 92.09 (a)
mouse
(Mus musculus)
Mammalia Eva1a 35
  • 81.46 (n)
  • 81.46 (a)
Eva1a 16
Eva1a 36
  • 85 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 62 (a)
ManyToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 31 (a)
ManyToMany
rat
(Rattus norvegicus)
Mammalia Eva1a 35
  • 84.35 (n)
  • 86.39 (a)
chicken
(Gallus gallus)
Aves -- 36
  • 71 (a)
ManyToMany
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 11 (a)
ManyToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia eva1a 35
  • 70.74 (n)
  • 75.54 (a)
zebrafish
(Danio rerio)
Actinopterygii eva1ba 36
  • 44 (a)
ManyToMany
LOC100331241 35
  • 67.39 (n)
  • 69.78 (a)
si:ch211-66i15.5 36
ManyToMany
fruit fly
(Drosophila melanogaster)
Insecta CG42402 36
  • 3 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea eva-1 36
  • 7 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
ManyToMany
Species with no ortholog for EVA1A:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for EVA1A Gene

ENSEMBL:
Gene Tree for EVA1A (if available)
TreeFam:
Gene Tree for EVA1A (if available)

Paralogs for EVA1A Gene

Paralogs for EVA1A Gene

Selected SIMAP similar genes for EVA1A Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with EVA1A: view

Variants for EVA1A Gene

Sequence variations from dbSNP and Humsavar for EVA1A Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type MAF
rs718507 -- 75,556,421(-) TCAGG(A/C)TTGGT intron-variant
rs725774 -- 75,567,647(+) TCTTC(C/G)ATTCA intron-variant
rs759255 -- 75,561,270(-) TGCTG(G/T)CAGGG upstream-variant-2KB, intron-variant
rs917922 -- 75,506,803(-) TTGTG(A/C/T)GGCAG intron-variant
rs990621 -- 75,494,039(-) GCTGT(C/G)TACCA intron-variant

Relevant External Links for EVA1A Gene

HapMap Linkage Disequilibrium report
EVA1A

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for EVA1A Gene

Disorders for EVA1A Gene

No disorders were found for EVA1A Gene.

No data available for UniProtKB/Swiss-Prot for EVA1A Gene

Publications for EVA1A Gene

  1. TMEM166, a novel transmembrane protein, regulates cell autophagy and apoptosis. (PMID: 17492404) Wang L. … Chen Y. (Apoptosis 2007) 3 4
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  3. Large-scale cDNA transfection screening for genes related to cancer development and progression. (PMID: 15498874) Wan D. … Gu J. (Proc. Natl. Acad. Sci. U.S.A. 2004) 3 4
  4. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PMID: 15815621) Hillier L.W. … Wilson R.K. (Nature 2005) 3 4
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 3

Products for EVA1A Gene

Sources for EVA1A Gene

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