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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

ETV7 Gene

protein-coding   GIFtS: 56
GCID: GC06M036380

Ets Variant 7

(Previous name: ets variant gene 7 (TEL2 oncogene))
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Ets Variant 71 2     ETS-Related Protein Tel22 3
TEL22 3 5     TEL-22
TELB2 3 5     Ets Transcription Factor TEL-2b2
Ets Variant Gene 7 (TEL2 Oncogene)1 2     Transcription Factor ETV72
TEL2 Oncogene1 2     TREF3
Tel-Related Ets Factor2 3     Transcription Factor Tel-23
ETS Translocation Variant 72 3     

External Ids:    HGNC: 181601   Entrez Gene: 515132   Ensembl: ENSG000000100307   OMIM: 6052555   UniProtKB: Q9Y6033   

Export aliases for ETV7 gene to outside databases

Previous GC identifers: GC06M036323 GC06M036430 GC06M036052


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for ETV7 Gene:
The protein encoded by this gene belongs to the ETS family of transcription factors, which is a large group of
evolutionarily conserved transcriptional regulators that play an important role in a variety of cellular
processes throughout development and differentiation, and are involved in oncogenesis as well. This protein is
predominantly expressed in hematopoietic tissues. Several alternatively spliced transcript variants encoding
different isoforms have been described for this gene (PMID:11108721).(provided by RefSeq, May 2011)

GeneCards Summary for ETV7 Gene: 
ETV7 (ets variant 7) is a protein-coding gene. Diseases associated with ETV7 include peripheral primitive neuroectodermal tumor, and primitive neuroectodermal tumor. GO annotations related to this gene include sequence-specific DNA binding and sequence-specific DNA binding transcription factor activity. An important paralog of this gene is ELF3.

UniProtKB/Swiss-Prot: ETV7_HUMAN, Q9Y603
Function: Transcriptional repressor; binds to the DNA sequence 5'-CCGGAAGT-3'. Isoform A does not seem to have a
repressor activity. Isoform C does not seem to have a repressor activity

Gene Wiki entry for ETV7 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000006.11  NT_007592.15  NC_018917.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the ETV7 gene promoter:
         Bach1   RP58   STAT1   AP-1   Bach2   MyoD   FOXL1   N-Myc   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): ETV7 promoter sequence
   Search SABiosciences Chromatin IP Primers for ETV7

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ETV7


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 6p21   Ensembl cytogenetic band:  6p21.31   HGNC cytogenetic band: 6p21

ETV7 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ETV7 gene location

GeneLoc information about chromosome 6         GeneLoc Exon Structure

GeneLoc location for GC06M036380:  view genomic region     (about GC identifiers)

Start:
36,321,998 bp from pter      End:
36,356,164 bp from pter
Size:
34,167 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: ETV7_HUMAN, Q9Y603 (See protein sequence)
Recommended Name: Transcription factor ETV7  
Size: 341 amino acids; 38998 Da
Subcellular location: Nucleus
Secondary accessions: B3KVC2 B4DVB6 B4E1G4 Q5R3L3 Q5R3L4 Q9NZ65 Q9NZ66 Q9NZ68 Q9NZR8 Q9UNJ7
Q9Y5K4 Q9Y604
Alternative splicing: 8 isoforms:  Q9Y603-1   Q9Y603-2   Q9Y603-3   Q9Y603-4   Q9Y603-5   Q9Y603-6   Q9Y603-7   Q9Y603-8   

Explore the universe of human proteins at neXtProt for ETV7: NX_Q9Y603

Explore proteomics data for ETV7 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q9Y603

  • ETV7 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    ETV7 Protein Expression
    REFSEQ proteins (8 alternative transcripts): 
    NP_001193964.1  NP_001193965.1  NP_001193966.1  NP_001193967.1  NP_001193968.1  NP_001193969.1  NP_001193970.1  NP_057219.1  

    ENSEMBL proteins: 
     ENSP00000341843   ENSP00000362842   ENSP00000342260   ENSP00000362843   ENSP00000440592  

    Human Recombinant Protein Products for ETV7: 
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    Novus Biologicals ETV7 Protein
    Novus Biologicals ETV7 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for ETV7 

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA--
    GO:0005730NOT nucleolus IDA--

    ETV7 for ontologies           About GeneDecksing



    ETV7 Antibody Products: 
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    Cloud-Clone Corp. Antibodies for ETV7 
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    LSBio Antibodies in human, mouse, rat for ETV7 

    Assay Products for ETV7: 
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    Cloud-Clone Corp. ELISAs for ETV7 
    Cloud-Clone Corp. CLIAs for ETV7


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    4 InterPro protein domains:
     IPR000418 Ets_dom
     IPR011991 WHTH_DNA-bd_dom
     IPR003118 Pointed_dom
     IPR013761 SAM/pointed

    Graphical View of Domain Structure for InterPro Entry Q9Y603

    ProtoNet protein and cluster: Q9Y603

    1 Blocks protein domain: IPB003118 Sterile alpha motif (SAM)/Pointed domain

    UniProtKB/Swiss-Prot: ETV7_HUMAN, Q9Y603
    Similarity: Belongs to the ETS family
    Similarity: Contains 1 ETS DNA-binding domain
    Similarity: Contains 1 PNT (pointed) domain


    ETV7 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ETV7_HUMAN, Q9Y603
    Function: Transcriptional repressor; binds to the DNA sequence 5'-CCGGAAGT-3'. Isoform A does not seem to have a
    repressor activity. Isoform C does not seem to have a repressor activity

         Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003700sequence-specific DNA binding transcription factor activity IEA--
    GO:0005515protein binding IPI12588862
    GO:0043565sequence-specific DNA binding IEA--
         
    ETV7 for ontologies           About GeneDecksing


    Phenotypes:
         3 GenomeRNAi human phenotypes for ETV7:
     G0/1 arrest  Increased G1 DNA content  Lamellipodia cells 

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for ETV7 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for ETV7

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for ETV7 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for ETV7 

    miRNA
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    1 QIAGEN miScript miRNA Assays for microRNA that regulate ETV7:
    hsa-miR-4323
    SwitchGear 3'UTR luciferase reporter plasmidETV7 3' UTR sequence
    Inhib. RNA
    Products:
        
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    Gene Editing
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    Sirion Biotech Customized adenovirus for overexpression of ETV7

    Clone
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    GenScript: all cDNA clones in your preferred vector: ETV7 (NM_016135)
    Browse Sino Biological Human cDNA Clones
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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ETV7


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for ETV7 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Transcriptional misregulation in cancer
    Transcriptional misregulation in cancer
    2Dorso-ventral axis formation
    Dorso-ventral axis formation

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways



    2         Kegg Pathways  (Kegg details for ETV7):
        Dorso-ventral axis formation
    Transcriptional misregulation in cancer


    ETV7 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for ETV7

    STRING Interaction Network Preview (showing 5 interactants - click image to see 6)

    5/6 Interacting proteins for ETV7 (Q9Y6033 ENSP000003418434) via UniProtKB, MINT, STRING, and/or I2D (see all 6)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    L3MBTL1Q9Y4683, ENSP000003622274I2D: score=2 STRING: ENSP00000362227
    IRF4Q153063, ENSP000003703434I2D: score=1 STRING: ENSP00000370343
    MAPK1ENSP000002158324STRING: ENSP00000215832
    MAPK3ENSP000002630254STRING: ENSP00000263025
    VTNENSP000002262184STRING: ENSP00000226218
    About this table

    Gene Ontology (GO): 3 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006355regulation of transcription, DNA-dependent ----
    GO:0006366transcription from RNA polymerase II promoter TAS10828014
    GO:0009887organ morphogenesis TAS10828014

    ETV7 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    ETV7 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for ETV7

    6 Novoseek inferred chemical compound relationships for ETV7 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    tyrosine 19.4 3 12149229 (1), 9695962 (1), 11435425 (1)
    12-o-tetradecanoylphorbol 13-acetate 11.5 1 9733767 (1)
    calcium 3.31 1 10406461 (1)
    estrogen 0 2 16344619 (1), 14603248 (1)
    retinoic acid 0 1 12485937 (1)
    rapamycin 0 1 16344619 (1)

    Search CenterWatch for drugs/clinical trials and news about ETV7

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for ETV7 gene (8 alternative transcripts): 
    NM_001207035.1  NM_001207036.1  NM_001207037.1  NM_001207038.1  NM_001207039.1  NM_001207040.1  NM_001207041.1  NM_016135.3  

    Unigene Cluster for ETV7:

    Ets variant 7
    Hs.272398  [show with all ESTs]
    Unigene Representative Sequence: AK122796
    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000340181(uc003omb.3 uc010jwj.3 uc010jwh.3) ENST00000373737(uc010jwi.3)
    ENST00000339796(uc003olz.2 uc003oma.2) ENST00000373738(uc003omc.3 uc011dtl.2)
    ENST00000538992
    miRNA
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    1 QIAGEN miScript miRNA Assays for microRNA that regulate ETV7:
    hsa-miR-4323
    SwitchGear 3'UTR luciferase reporter plasmidETV7 3' UTR sequence
    Inhib. RNA
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    DNA2.0 Custom Codon Optimized Gene Synthesis Service for ETV7
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ETV7
    Sirion Biotech Customized lentivirus for stable overexpression of ETV7 
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    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for ETV7
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ETV7
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ETV7

    Additional mRNA sequence: 

    AF116508.1 AF116509.1 AF116510.1 AF147782.1 AF175387.3 AF218235.1 AF218365.1 AF218366.1 
    AJ276205.1 AK026144.1 AK122796.1 AK223424.1 AK301011.1 AK303829.1 BC035853.1 

    5 DOTS entries:

    DT.92422677  DT.75129627  DT.92422678  DT.75182687  DT.100670488 

    24/45 AceView cDNA sequences (see all 45):

    AA604808 AF218366 AI242250 AF116510 AA748867 AI394727 CR622547 AF116509 
    AF218365 AF218235 AJ276205 CB854636 BI963015 AI351841 AF116508 BF195445 
    BF000323 NM_016135 BC035853 AK122796 BX480420 AI829933 AK026144 BF438065 

    GeneLoc Exon Structure

    5/8 Alternative Splicing Database (ASD) splice patterns (SP) for ETV7 (see all 8)    About this scheme

    ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4a · 4b ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9 ^ 10
    SP1:                    -                 -                                             
    SP2:                    -                                                               
    SP3:                    -                 -                 -                           
    SP4:                    -     -           -                                             
    SP5:                    -           -     -                                             


    ECgene alternative splicing isoforms for ETV7

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    ETV7 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: ACCTTGGATT
    ETV7 Expression
    About this image


    See ETV7 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for ETV7

    SOURCE GeneReport for Unigene cluster: Hs.272398

    UniProtKB/Swiss-Prot: ETV7_HUMAN, Q9Y603
    Tissue specificity: Expressed in hematopoietic tissues

        SABiosciences Custom PCR Arrays for ETV7
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ETV7

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for ETV7 gene from 6/9 species (see all 9)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    dog
    (Canis familiaris)
    Mammalia ETV71 ets variant 7 83.73(n)
    77.41(a)
      481764  XM_538885.3  XP_538885.3 
    chicken
    (Gallus gallus)
    Aves ETV71 ets variant 7 66.05(n)
    65.68(a)
      419813  XM_417949.3  XP_417949.2 
    lizard
    (Anolis carolinensis)
    Reptilia ETV76
    Uncharacterized protein
    43(a)
    1 ↔ 1
    4(123406900-123421692)
    zebrafish
    (Danio rerio)
    Actinopterygii etv71 ets variant 7 55.63(n)
    52.98(a)
      100009655  NM_001083024.1  NP_001076493.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta aop6
    anterior open
    15(a)
    1 → many
    2L(2156484-2178749)
    worm
    (Caenorhabditis elegans)
    Secernentea ets-86
    ets-76
    (see all 3)
    Protein ETS-7
    (see all 3)
    26(a)
    17(a)
    (see all 3)
    many ↔ many
    many ↔ many
    (see all 3)
    IV(1159637-1161545)
    V(7557757-7558783)


    ENSEMBL Gene Tree for ETV7 (if available)
    TreeFam Gene Tree for ETV7 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for ETV7 gene
    ELF32  ELF42  ELF12  ELF52  EHF2  ELF22  SPDEF2  ETV62  
    1 SIMAP similar gene for ETV7 using alignment to 1 protein entry:     ETV7_HUMAN:
    ELF5

    ETV7 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/995 SNPs in ETV7 are shown (see all 995)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 6 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs77689391,2
    C,A,H--36064838(+) ATATGA/GAAAAA 8 -- int1 trp30--------
    rs339707631,2
    C--36069599(+) TGAAG-/TAGGCC 8 -- int10--------
    rs1488096131,2
    --36232603(+) TAATTG/TAATCA 2 -- ds50010--------
    rs1415697391,2
    --36232632(+) CTCCCA/GTGCTG 2 -- ds50010--------
    rs1508934611,2
    --36232725(+) GCCACG/TATGTA 2 -- ds50010--------
    rs1123596211,2
    C,F--36232837(+) GTCTCG/AGGTAT 2 -- ds50012Minor allele frequency- A:0.10WA 120
    rs1171189671,2
    C,F--36232866(+) AAAACG/AGACTA 2 -- ds50011Minor allele frequency- A:0.03EA 120
    rs1832301911,2
    --36232875(+) TAATAC/GAATGA 2 -- ds50010--------
    rs1867577391,2
    --36232970(+) GTTTTG/TTGTCT 2 -- ds50010--------
    rs800065311,2
    F--36232977(+) GTCTTT/CTTATT 2 -- ds50011Minor allele frequency- C:0.07NA 120

    HapMap Linkage Disequilibrium report for ETV7 (36321998 - 36356164 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for ETV7:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv1651866CNV Insertion17803354
    nsv885806CNV Gain21882294
    esv8401CNV Gain19470904

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 605255    OMIM disorders: --

    20/29 diseases for ETV7 (see all 29):    About MalaCards
    peripheral primitive neuroectodermal tumor    primitive neuroectodermal tumor    ewing's family of tumors    familial prostate cancer
    abdominal aortic aneurysm    synovial sarcoma    aortic aneurysm    endometrial carcinoma
    polycystic kidney disease    oral squamous cell carcinoma    kidney disease    conjunctivitis
    retinoblastoma    prostate cancer    diffuse large b-cell lymphoma    insulinoma
    b-cell lymphomas    sarcoma    prostatitis    multiple sclerosis


    ETV7 for disorders           About GeneDecksing

    10/21 Novoseek inferred disease relationships for ETV7 gene (see all 21)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    ewings sarcoma 71.8 11 18927503 (2), 11550284 (1), 12907633 (1), 12557222 (1) (see all 10)
    prostate cancer 45.5 23 20479932 (2), 18037958 (1), 16575200 (1), 18245377 (1) (see all 18)
    tumors 43.3 23 14662758 (2), 9467955 (1), 12888293 (1), 18567002 (1) (see all 22)
    erythroleukemia 38 2 17374502 (1), 12556498 (1)
    cancer 37.4 13 15298723 (2), 16307850 (1), 16213704 (1), 12898592 (1) (see all 9)
    primitive neuroectodermal tumor pnet 32.3 2 12557222 (1), 11313995 (1)
    metastasis 31.7 8 9467955 (1), 10564827 (1), 12584571 (1), 15298723 (1) (see all 8)
    leukemia 28 3 14557674 (1), 12588862 (1), 9694803 (1)
    breast cancer 26.4 6 19505923 (2), 18922924 (1), 16897429 (1), 19566835 (1) (see all 5)
    ovarian carcinoma 20.4 2 12716042 (1), 17305482 (1)

    Genetic Association Database (GAD): ETV7
    Human Genome Epidemiology (HuGE) Navigator: ETV7 (1 document)

    Export disorders for ETV7 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for ETV7 gene, integrated from 9 sources (see all 234):
    (articles sorted by number of sources associating them with ETV7)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Identification and characterization of a new human ETS-family transcription factor, TEL2, that is expressed in hematopoietic tissues and can associate with TEL1/ETV6. (PubMed id 10828014)1, 2, 3, 9 Potter M.D.... Grosveld G.C. (2000)
    2. Tel-2 is a novel transcriptional repressor related to the Ets factor Tel/ETV-6. (PubMed id 11108721)1, 2, 3 Gu X....Libermann T.A. (2001)
    3. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (2010)
    4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    6. The DNA sequence and analysis of human chromosome 6. (PubMed id 14574404)1, 2 Mungall A.J.... Beck S. (2003)
    7. Characterization of a novel ETS gene, TELB encoding a protein structurally and functionally related to TEL. (PubMed id 11032031)1, 2 Poirel H.... Bernard O.A. (2000)
    8. The human L(3)MBT Polycomb group protein is a transcriptional repressor and interacts physically and functionally with TEL (ETV6). (PubMed id 12588862)1, 9 Boccuni P.... Nimer S.D. (2003)
    9. A proteome-wide, quantitative survey of in vivo ubiqui tylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (2011)
    10. Toward an understanding of the protein interaction net work of the human liver. (PubMed id 21988832)1 Wang J....Yang X. (2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 51513 HGNC: 18160 AceView: ETV7 Ensembl:ENSG00000010030 euGenes: HUgn51513
    ECgene: ETV7 Kegg: 51513 H-InvDB: ETV7

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for ETV7 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for ETV7 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for ETV7 gene:
    Search GeneIP for patents involving ETV7

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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