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Aliases for ETV7 Gene

Aliases for ETV7 Gene

  • ETS Variant 7 2 3 5
  • Ets Variant Gene 7 (TEL2 Oncogene) 2 3
  • ETS Translocation Variant 7 3 4
  • ETS-Related Protein Tel2 3 4
  • Tel-Related Ets Factor 3 4
  • TEL2 Oncogene 2 3
  • TEL2 3 4
  • TELB 3 4
  • Ets Transcription Factor TEL-2b 3
  • Transcription Factor Tel-2 4
  • Transcription Factor ETV7 3
  • TEL-2 3
  • TREF 4

External Ids for ETV7 Gene

Previous GeneCards Identifiers for ETV7 Gene

  • GC06M036323
  • GC06M036380
  • GC06M036430
  • GC06M036052
  • GC06M036381
  • GC06M036383
  • GC06M036536
  • GC06M036680
  • GC06M037030

Summaries for ETV7 Gene

Entrez Gene Summary for ETV7 Gene

  • The protein encoded by this gene belongs to the ETS family of transcription factors, which is a large group of evolutionarily conserved transcriptional regulators that play an important role in a variety of cellular processes throughout development and differentiation, and are involved in oncogenesis as well. This protein is predominantly expressed in hematopoietic tissues. Several alternatively spliced transcript variants encoding different isoforms have been described for this gene (PMID:11108721).[provided by RefSeq, May 2011]

GeneCards Summary for ETV7 Gene

ETV7 (ETS Variant 7) is a Protein Coding gene. Diseases associated with ETV7 include Ewing Sarcoma. Among its related pathways are Dorso-ventral axis formation and Transcriptional misregulation in cancer. GO annotations related to this gene include transcription factor activity, sequence-specific DNA binding and RNA polymerase II transcription factor activity, sequence-specific DNA binding. An important paralog of this gene is ETV6.

UniProtKB/Swiss-Prot for ETV7 Gene

  • Transcriptional repressor; binds to the DNA sequence 5-CCGGAAGT-3. Isoform A does not seem to have a repressor activity. Isoform C does not seem to have a repressor activity.

Gene Wiki entry for ETV7 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ETV7 Gene

Genomics for ETV7 Gene

Regulatory Elements for ETV7 Gene

Enhancers for ETV7 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH06G036422 1.9 FANTOM5 Ensembl ENCODE dbSUPER 51.4 -35.7 -35730 2.0 MLX CREB3L1 ARID4B SIN3A ZNF2 YY1 ZNF766 ZNF143 ZNF207 FOS ETV7 KCTD20 LOC105375037 C6orf222 STK38 PI16 MAPK13 PXT1 SRSF3 CDKN1A
GH06G036439 1.8 FANTOM5 ENCODE dbSUPER 31.9 -55.0 -55048 6.9 MLX CREB3L1 FEZF1 DMAP1 YY1 ZNF143 ZNF263 SP3 NFYC MEF2D ETV7 KCTD20 PXT1 LOC105375037 CDKN1A RPL10A PI16 MAPK14 SRSF3 BRPF3
GH06G036427 1.2 ENCODE dbSUPER 38.5 -40.4 -40379 0.8 PKNOX1 ATF1 CREB3L1 ARNT TCF12 GTF3C2 GATA2 FOS ZNF592 SMARCA4 ETV7 TBC1D22B ENSG00000219023 FANCE LOC105375037 ENSG00000237719 STK38 PI16 RPL10A KCTD20
GH06G036386 0.9 ENCODE 47 +0.4 423 2.5 NFIB BMI1 GLIS2 ZNF366 ZSCAN5C RELB ETV6 IKZF2 ZNF680 CBFB ETV7 KCTD20 LOC105375037
GH06G036592 3 FANTOM5 Ensembl ENCODE dbSUPER 13.4 -209.6 -209619 10.7 MLX CREB3L1 ZFP64 DMAP1 YBX1 YY1 SLC30A9 ZNF143 ZNF263 SP3 KCTD20 CDKN1A RAB44 STK38 TBC1D22B ETV7 LAP3P2 ENSG00000251864 ENSG00000237719 CMTR1
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around ETV7 on UCSC Golden Path with GeneCards custom track

Promoters for ETV7 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000320453 0 401 CTCF ZNF211 SUZ12 BMI1 RBBP5 EBF1 EED ETV6 IKZF2 EZH2
ENSR00000196201 1099 1000 CTCF IRF2 SUZ12 NFIB RBBP5 GLIS2 ZSCAN5C EZH2 ZNF680 NFIA

Genomic Location for ETV7 Gene

Chromosome:
6
Start:
36,354,091 bp from pter
End:
36,387,800 bp from pter
Size:
33,710 bases
Orientation:
Minus strand

Genomic View for ETV7 Gene

Genes around ETV7 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ETV7 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ETV7 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ETV7 Gene

Proteins for ETV7 Gene

  • Protein details for ETV7 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9Y603-ETV7_HUMAN
    Recommended name:
    Transcription factor ETV7
    Protein Accession:
    Q9Y603
    Secondary Accessions:
    • B3KVC2
    • B4DVB6
    • B4E1G4
    • Q5R3L3
    • Q5R3L4
    • Q9NZ65
    • Q9NZ66
    • Q9NZ68
    • Q9NZR8
    • Q9UNJ7
    • Q9Y5K4
    • Q9Y604

    Protein attributes for ETV7 Gene

    Size:
    341 amino acids
    Molecular mass:
    38998 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for ETV7 Gene

neXtProt entry for ETV7 Gene

Post-translational modifications for ETV7 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for ETV7 Gene

Domains & Families for ETV7 Gene

Gene Families for ETV7 Gene

Suggested Antigen Peptide Sequences for ETV7 Gene

Graphical View of Domain Structure for InterPro Entry

Q9Y603

UniProtKB/Swiss-Prot:

ETV7_HUMAN :
  • Belongs to the ETS family.
Family:
  • Belongs to the ETS family.
genes like me logo Genes that share domains with ETV7: view

Function for ETV7 Gene

Molecular function for ETV7 Gene

UniProtKB/Swiss-Prot Function:
Transcriptional repressor; binds to the DNA sequence 5-CCGGAAGT-3. Isoform A does not seem to have a repressor activity. Isoform C does not seem to have a repressor activity.

Gene Ontology (GO) - Molecular Function for ETV7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000977 RNA polymerase II regulatory region sequence-specific DNA binding IDA 11108721
GO:0001227 transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding IDA 11108721
GO:0003677 DNA binding IEA --
GO:0003700 transcription factor activity, sequence-specific DNA binding IEA --
GO:0005515 protein binding IPI 12588862
genes like me logo Genes that share ontologies with ETV7: view
genes like me logo Genes that share phenotypes with ETV7: view

Animal Model Products

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ETV7 Gene

Localization for ETV7 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ETV7 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ETV7 gene
Compartment Confidence
nucleus 5
cytosol 2
peroxisome 1

Gene Ontology (GO) - Cellular Components for ETV7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus TAS 10828014
GO:0005654 nucleoplasm IDA --
genes like me logo Genes that share ontologies with ETV7: view

Pathways & Interactions for ETV7 Gene

genes like me logo Genes that share pathways with ETV7: view

Pathways by source for ETV7 Gene

Gene Ontology (GO) - Biological Process for ETV7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription from RNA polymerase II promoter IDA 11108721
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0006366 transcription from RNA polymerase II promoter TAS 10828014
GO:0009887 animal organ morphogenesis TAS 10828014
genes like me logo Genes that share ontologies with ETV7: view

No data available for SIGNOR curated interactions for ETV7 Gene

Drugs & Compounds for ETV7 Gene

(4) Drugs for ETV7 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(2) Additional Compounds for ETV7 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with ETV7: view

Transcripts for ETV7 Gene

Unigene Clusters for ETV7 Gene

Ets variant 7:
Representative Sequences:

CRISPR Products

Alternative Splicing Database (ASD) splice patterns (SP) for ETV7 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4a · 4b ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9 ^ 10
SP1: - -
SP2: -
SP3: - - -
SP4: - - -
SP5: - - -
SP6: - - - -
SP7: - -
SP8: -

Relevant External Links for ETV7 Gene

GeneLoc Exon Structure for
ETV7
ECgene alternative splicing isoforms for
ETV7

Expression for ETV7 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ETV7 Gene

mRNA differential expression in normal tissues according to GTEx for ETV7 Gene

This gene is overexpressed in Skin - Sun Exposed (Lower leg) (x5.1) and Skin - Not Sun Exposed (Suprapubic) (x4.9).

NURSA nuclear receptor signaling pathways regulating expression of ETV7 Gene:

ETV7

SOURCE GeneReport for Unigene cluster for ETV7 Gene:

Hs.272398

mRNA Expression by UniProt/SwissProt for ETV7 Gene:

Q9Y603-ETV7_HUMAN
Tissue specificity: Expressed in hematopoietic tissues.

Evidence on tissue expression from TISSUES for ETV7 Gene

  • Blood(4.1)
  • Intestine(4.1)
  • Lung(4.1)
  • Pancreas(4.1)
  • Nervous system(4.1)
genes like me logo Genes that share expression patterns with ETV7: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for ETV7 Gene

Orthologs for ETV7 Gene

This gene was present in the common ancestor of animals.

Orthologs for ETV7 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ETV7 34 35
  • 99.32 (n)
dog
(Canis familiaris)
Mammalia ETV7 34 35
  • 83.73 (n)
oppossum
(Monodelphis domestica)
Mammalia ETV7 35
  • 65 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia ETV7 35
  • 59 (a)
OneToOne
chicken
(Gallus gallus)
Aves ETV7 34 35
  • 62.93 (n)
lizard
(Anolis carolinensis)
Reptilia ETV7 35
  • 44 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii etv7 35 34
  • 55.96 (n)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta Eip74EF 35
  • 8 (a)
ManyToMany
worm
(Caenorhabditis elegans)
Secernentea ets-4 35
  • 16 (a)
OneToMany
Species where no ortholog for ETV7 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for ETV7 Gene

ENSEMBL:
Gene Tree for ETV7 (if available)
TreeFam:
Gene Tree for ETV7 (if available)

Paralogs for ETV7 Gene

Paralogs for ETV7 Gene

(1) SIMAP similar genes for ETV7 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with ETV7: view

Variants for ETV7 Gene

Sequence variations from dbSNP and Humsavar for ETV7 Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type
rs1000021951 -- 36,363,229(+) CGCAT(A/C/T)TGGAG intron-variant
rs1000052162 -- 36,369,247(+) GTCTC(A/G)GGCAG intron-variant
rs1000176104 -- 36,367,831(+) CTGCT(G/T)CCCCA intron-variant
rs1000196483 -- 36,355,321(+) TTTCC(C/T)TATCT intron-variant
rs1000227509 -- 36,355,643(+) CCTGG(C/T)CTCAA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ETV7 Gene

Variant ID Type Subtype PubMed ID
esv1651866 CNV insertion 17803354
esv2762586 CNV gain 21179565
esv8401 CNV gain 19470904
nsv1119081 CNV deletion 24896259
nsv1150801 CNV insertion 26484159
nsv473235 CNV novel sequence insertion 20440878

Variation tolerance for ETV7 Gene

Residual Variation Intolerance Score: 81.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.35; 63.23% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ETV7 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ETV7

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ETV7 Gene

Disorders for ETV7 Gene

MalaCards: The human disease database

(1) MalaCards diseases for ETV7 Gene - From: Novoseek and GeneCards

Disorder Aliases PubMed IDs
ewing sarcoma
  • neuroepithelioma
- elite association - COSMIC cancer census association via MalaCards
Search ETV7 in MalaCards View complete list of genes associated with diseases

Relevant External Links for ETV7

Genetic Association Database (GAD)
ETV7
Human Genome Epidemiology (HuGE) Navigator
ETV7
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ETV7
genes like me logo Genes that share disorders with ETV7: view

No data available for UniProtKB/Swiss-Prot and Genatlas for ETV7 Gene

Publications for ETV7 Gene

  1. Identification and characterization of a new human ETS-family transcription factor, TEL2, that is expressed in hematopoietic tissues and can associate with TEL1/ETV6. (PMID: 10828014) Potter M.D. … Grosveld G.C. (Blood 2000) 2 3 4 22 64
  2. Tel-2, a novel transcriptional repressor related to the Ets factor Tel/ETV-6. (PMID: 11108721) Gu X. … Libermann T.A. (J. Biol. Chem. 2001) 2 3 4 64
  3. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 46 64
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64

Products for ETV7 Gene

Sources for ETV7 Gene

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