ETV6 Gene
protein-coding GIFtS: 60
GCID: GC12P011703
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|
ets variant 6(Previous name: ets variant gene 6 (TEL oncogene) )
| |
Aliases
for ETV6 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Ets Variant 61 2 | | TEL/ABL2 | | TEL1 2 3 5 | | TEL1 Oncogene2 | | Ets Variant Gene 6 (TEL Oncogene)1 2 | | Transcription Factor ETV62 | | ETS Translocation Variant 62 3 | | TEL13 | | ETS-Related Protein Tel12 3 | | Tel3 |
Export aliases for ETV6 gene to outside databasesPrevious GC identifers: GC12P011530 GC12P011947 GC12P011694 GC12P011670 |
Summaries
for ETV6 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for ETV6:
This gene encodes an ETS family transcription factor. The product of this gene contains two functional domains: aN-terminal pointed (PNT) domain that is involved in protein-protein interactions with itself and other proteins, and aC-terminal DNA-binding domain. Gene knockout studies in mice suggest that it is required for hematopoiesis andmaintenance of the developing vascular network. This gene is known to be involved in a large number of chromosomalrearrangements associated with leukemia and congenital fibrosarcoma. (provided by RefSeq, Sep 2008)
UniProtKB/Swiss-Prot: ETV6_HUMAN, P41212Function: Transcriptional repressor; binds to the DNA sequence 5'-CCGGAAGT-3'
Gene Wiki entry for ETV6
|
Genomic Views
for ETV6 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000012.11 NC_018923.1 NT_009714.17
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the ETV6 gene promoter:
AML1a
Other transcription factors
Search SABiosciences Chromatin IP Primers for ETV6
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ETV6 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 12p13 Ensembl cytogenetic band: 12p13.2 HGNC cytogenetic band: 12p13ETV6 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 12 GeneLoc Exon Structure GeneLoc location for GC12P011703: view genomic region
(about GC identifiers)
Start:
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11,802,788 bp from pter |
End:
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12,048,336 bp from pter |
Size:
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245,549 bases |
Orientation:
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plus strand |
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Proteins
for ETV6 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: ETV6_HUMAN, P41212 (See
protein sequence)Recommended Name: Transcription factor ETV6 Size: 452 amino acids; 53000 Da
Subunit: Can form homodimers or heterodimers with TEL2 or FLI1. Interacts with L3MBTL1 and HDAC9
Subcellular location: Nucleus
Sequence caution: Sequence=ABI30005.1; Type=Erroneous initiation; Note=Translation N-terminally shortened;
6 PDB 3D structures from  and Proteopedia  for ETV6:1JI7 (3D)
1LKY (3D)
2DAO (3D)
2QAR (3D)
2QB0 (3D)
2QB1 (3D)
Secondary accessions: A3QVP6 A8K076 Q9UMF6 Q9UMF7 Q9UMG0Explore the universe of human proteins at neXtProt for ETV6: NX_P41212
Post-translational modifications:
Phosphorylation of Ser-257 by MAPK14 (p38) inhibits ETV6 transcriptional repression1
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_P41212
ETV6 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_001978.1
ENSEMBL proteins: ENSP00000379658 ENSP00000441463 ENSP00000266427
Human Recombinant Protein Products:
Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005634 | nucleus |
IEA | -- |
ETV6 for ontologies About GeneDecksing
ETV6 Antibody Products:
Assay Products for ETV6: |
Protein
Domains /
Families
for ETV6 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
ETV6 for domains About GeneDecksing
4 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry P41212ProtoNet protein and cluster: P41212 1 Blocks protein family: IPB003118 Sterile alpha motif (SAM)/Pointed domain
UniProtKB/Swiss-Prot: ETV6_HUMAN, P41212Similarity: Belongs to the ETS familySimilarity: Contains 1 ETS DNA-binding domainSimilarity: Contains 1 PNT (pointed) domain |
Function
for ETV6 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: ETV6_HUMAN, P41212Function: Transcriptional repressor; binds to the DNA sequence 5'-CCGGAAGT-3' Genatlas biochemistry entry for ETV6:ETS variant 6,transcriptional repressor,required for hematopoiesis in bone marrow,involved in chronic myelomonocyticleukemia (see CMML) with translocations t(5;12)(q33;p13), t(10;12)(q24;p13);in CML with translocationt(9;12)(q34;p13);in ALL and in B cell precursor ALL with favorable outcome and translocationst(5;12)(q31-q33;p12),t(9;12) (p24;p13),t(12.21)(p13;q22) (see AML1),t(6;12)(q23;p13),(see STL),and in myelodysplasiaand myeloproliferative disorders with translocation t(3;12)(q26;p13),(1;12)(p13 or q31;p13) (14;12) (q11;p13) t(12;22)(p13;q11),t(12;15) (p13;q25),t(12;13)(p13-q12),in acute myeloid leukemia with translocation (4;12) (q11-q12;p13) (seeCDX2) in congenital fibrosarcoma (CFS),in congenital mesoblastic nephroma and in biphenotypic adult leukemia(BIPL),see MDS1,EVI1,also involved in malignancies with hemizygous deletions
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ETV6 (see all 4)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ETV6
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: ETV6 (NM_001987) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for ETV6 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ETV6 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ETV6 |
Gene Ontology (GO): 5 molecular function terms (GO ID links to tree view): About this table
ETV6 for ontologies About GeneDecksing
1 GenomeRNAi human phenotype for ETV6:
Animal Models:
Mouse knock-outs for ETV6: Etv6tm1Sho Etv6tm2.1Sho
14 MGI mutant phenotypes (inferred from 7 alleles ) (MGI details for Etv6):
ETV6 for phenotypes About GeneDecksing
|
Pathways & Interactions
for ETV6 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Diurnally regulated genes with circadian orthologs | | | 2 | Dorso-ventral axis formation | |
Pathway sources
See GeneCards unified pathways
Show all pathways
1  BioSystems Pathway for ETV6
1 
Kegg Pathway (Kegg details for ETV6):
ETV6 for pathways About GeneDecksing
Interactions:
SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for ETV6
STRING Interaction
Network Preview (showing 5 interactants - click image to see 25)
5/780 Interacting proteins for ETV6 (P412121, 2, 3 ENSP000002664274) via UniProtKB, MINT, STRING, and/or I2D (see all 780)About this table
Gene Ontology (GO): 3 biological process terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0006351 | transcription, DNA-dependent |
IEA | -- | | GO:0006355 | regulation of transcription, DNA-dependent |
-- | -- | | GO:0030154 | cell differentiation |
IEA | -- |
ETV6 for ontologies About GeneDecksing
|
Drugs & Compounds
for ETV6 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
ETV6 for compounds About GeneDecksing
 Browse Tocris compounds for ETV6
6 Novoseek chemical compound relationships for ETV6 gene About this table
Search CenterWatch for drugs/clinical trials and news about ETV6
|
Transcripts
for ETV6 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for ETV6 gene: NM_001987.4 Unigene Cluster for ETV6: Ets variant 6 Hs.504765 [show with all ESTs]Unigene Representative Sequence: NM_0019875 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000396373(uc001qzz.3 uc001raa.1) ENST00000541426 ENST00000544715
ENST00000545027 ENST00000266427
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ETV6 (see all 4)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ETV6
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: ETV6 (NM_001987) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for ETV6 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ETV6 |
Additional cDNA sequence: AK289441.1 BC020284.1 BC043399.1 BC061911.1 DQ451147.1 EU364772.1 FR719953.1 U11732.1 Z35761.1 13 DOTS entries: DT.215338 DT.114998 DT.411164 DT.70104091 DT.121174815 DT.65287167 DT.40131416 DT.75142931 DT.99991732 DT.121175075 DT.95257518 DT.92063108 DT.97837384 24/225 AceView cDNA sequences (see all 225): CA309586 BU507161 BM683130 AA773253 AW953495 NM_001987 D79095 AI598130 BU630424 AA347200 AI200299 Z44378 AI268890 CB243807 BM982346 AA928496 AI400044 Z40311 BU623106 AA983191 N67347 AI123905 AW027091 BQ003277
GeneLoc Exon Structure
|
Expression
for ETV6 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| ETV6 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: CCAAGTGAAC
About this image
See ETV6 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for ETV6
SOURCE GeneReport for Unigene cluster: Hs.504765
UniProtKB/Swiss-Prot: ETV6_HUMAN, P41212Tissue specificity: Ubiquitous
SABiosciences Expression via Pathway-Focused PCR Array including ETV6:
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for ETV6
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat ETV6 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ETV6 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ETV6 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ETV6 |
Orthologs
for ETV6 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals.
Orthologs for ETV6 gene from 5/16 species (see all 16) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
chicken
(Gallus gallus) |
Aves |
ETV61 |
ets variant gene 6 (TEL oncogene) |
82.26(n)
87.58(a) |
|
395750 NM_001199273.1 NP_001186202.1 |
lizard
(Anolis carolinensis) |
Reptilia |
ETV66 |
-- |
87(a) |
1 ↔ 1 |
5(83153337-83183481) |
tropical clawed frog
(Xenopus tropicalis) |
Amphibia |
Str.69362 |
Transcribed sequence with weak similarity to protein more |
77.01(n) |
|
142005230 |
zebrafish
(Danio rerio) |
Actinopterygii |
etv62 |
ets variant gene 6 (TEL oncogene) |
80.22(n) |
|
114444 AF339838.1 |
fruit fly
(Drosophila melanogaster) |
Insecta |
aop6 |
anterior open |
12(a) |
1 → many |
2L(2156484-2178749) |
ENSEMBL Gene Tree for ETV6 (if available)
TreeFam Gene Tree for ETV6 (if available) |
Paralogs
for ETV6 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for ETV6 gene
- ELF32 ELF42 ELF12 ELF52 ETV72 ELF22 SPDEF2 EHF2
2 SIMAP similar genes for ETV6 using alignment to 6 protein entries: ETV6_HUMAN (see all proteins):ELK1 ELF5
ETV6 for paralogs About GeneDecksing
|
Genomic Variants
for ETV6 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 12 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for ETV6 (11802788 - 12048336 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 14 variations for ETV6
7 CNVs: 48963 101435 48962 48961 48960 48959 53162
7 Indels: 44976 75954 86219 86217 75953 86218 66142 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing ETV6 |
|
Disorders
/ Diseases
for ETV6 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database, Novoseek,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
ETV6 for disorders About GeneDecksing
OMIM gene information: 600618
OMIM disorders: 601626
UniProtKB/Swiss-Prot: ETV6_HUMAN, P41212
Note=A chromosomal aberration involving ETV6 is found in a form of chronic myelomonocytic leukemia (CMML).Translocation t(5;12)(q33;p13) with PDGFRB. It is characterized by abnormal clonal myeloid proliferation and byprogression to acute myelogenous leukemia (AML) Note=Chromosomal aberrations involving ETV6 are found in a form of acute myeloid leukemia (AML). Translocationt(12;22)(p13;q11) with MN1; translocation t(4;12)(q12;p13) with CHIC2 Note=Chromosomal aberrations involving ETV6 are found in childhood acute lymphoblastic leukemia (ALL).Translocations t(12;21)(p12;q22) and t(12;21)(p13;q22) with RUNX1/AML1 Note=A chromosomal aberration involving ETV6 is found in a form of pre-B acute myeloid leukemia. Translocationt(9;12)(p24;p13) with JAK2 Note=A chromosomal aberration involving ETV6 is found in myelodysplastic syndrome (MDS) with basophilia.Translocation t(5;12)(q31;p13) with ACSL6 Note=A chromosomal aberration involving ETV6 is found in acute eosinophilic leukemia (AEL). Translocationt(5;12)(q31;p13) with ACSL6 Note=A chromosomal aberration involving ETV6 is found in myelodysplastic syndrome (MDS). Translocationt(1;12)(p36.1;p13) with MDS2 Defects in ETV6 are a cause of myeloproliferative disorder chronic with eosinophilia (MPE) [MIM:131440]. Ahematologic disorder characterized by malignant eosinophils proliferation. Note=A chromosomal aberration involvingETV6 is found in many instances of myeloproliferative disorder chronic with eosinophilia. Translocation t(5;12) withPDGFRB on chromosome 5 creating an ETV6-PDGFRB fusion protein Defects in ETV6 are a cause of acute myelogenous leukemia (AML) [MIM:601626]. AML is a malignant disease inwhich hematopoietic precursors are arrested in an early stage of development Note=A chromosomal aberration involving ETV6 is found in acute lymphoblastic leukemia. Translocationt(9;12)(p13;p13) with PAX5
20/50  diseases for ETV6 (see all 50): About MalaCardscongenital fibrosarcoma fibrosarcoma leukemia pre-b-cell acute lymphoblastic leukemia
congenital mesoblastic nephroma hematopoiesis leukemia, acute myeloid, somatic mesoblastic nephroma
acute lymphoblastic leukemia lymphoblastic leukemia testicular germ cell tumor prolymphocytic leukemia
acute lymphoblastic leukemia, childhood germ cell tumor polycythemia vera myeloid leukemia
megakaryoblastic leukemia myelomonocytic leukemia t-cell prolymphocytic leukemia myeloproliferative disorder
3 diseases from the University of Copenhagen DISEASES database for ETV6:Leukemia Congenital fibrosarcoma Congenital mesoblastic nephroma 10/37 Novoseek disease relationships for ETV6 gene (see all 37) About this table
| Disease |
-log (P-Val) |
Hits |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| lymphoblastic leukemia acute childhood |
87.6 |
24 |
9264370 (2), 9373267 (2), 18445843 (1), 18281529 (1) (see all 18) |
| lymphoblastic leukemia acute |
83.7 |
31 |
12764377 (2), 16490598 (2), 7795247 (1), 9204978 (1) (see all 26) |
| leukemogenesis |
83.5 |
20 |
16038737 (2), 15806161 (1), 18728978 (1), 11157492 (1) (see all 16) |
| leukemia |
76.4 |
69 |
17069581 (3), 16643428 (3), 9060558 (3), 8754809 (2) (see all 50) |
| hematologic malignancies |
73.1 |
25 |
9454771 (3), 9523197 (2), 7795247 (1), 11347199 (1) (see all 15) |
| myelodysplastic syndromes |
67.2 |
17 |
18476590 (2), 9171997 (2), 8695816 (2), 16757412 (2) (see all 11) |
| leukemia myelomonocytic chronic |
67 |
3 |
9031109 (1), 7761424 (1), 8168137 (1) |
| chromosomal aberrations |
64.2 |
6 |
8695816 (1), 9365838 (1), 19480935 (1), 10557049 (1) |
| nephroma mesoblastic |
62.2 |
1 |
11743047 (1) |
| acute leukemia |
61 |
12 |
11343784 (3), 8808688 (1), 12823350 (1), 7780150 (1) (see all 8) |
Human Genome Epidemiology (HuGE) Navigator: ETV6 (8 documents)
Export disorders for ETV6 gene to outside databases
|
Publications
for ETV6 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for ETV6 gene, integrated from 9 sources (see all 363):
(articles sorted by number of sources associating them with ETV6) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Somatic heterozygous mutations in ETV6 (TEL) and frequent absence of ETV6 protein in acute myeloid leukemia. (PubMed id 15806161)1, 2, 9 Barjesteh van Waalwijk van Doorn-Khosrovani S.... Delwel R. (2005)
- The human L(3)MBT Polycomb group protein is a transcriptional repressor and interacts physically and functionally with TEL (ETV6). (PubMed id 12588862)1, 2, 9 Boccuni P.... Nimer S.D. (2003)
- Functional regulation of TEL by p38-induced phosphorylation. (PubMed id 12435397)1, 2, 9 Arai H.... Mitani K. (2002)
- Genomic organization of TEL: the human ETS-variant gene 6. (PubMed id 8743990)1, 2, 9 Baens M.... Marynen P. (1996)
- Fusion of the TEL gene on 12p13 to the AML1 gene on 21q22 in acute lymphoblastic leukemia. (PubMed id 7761424)1, 2, 9 Golub T.R.... Gilliland D.G. (1995)
- The t(12;21) of acute lymphoblastic leukemia results in a tel-AML1 gene fusion. (PubMed id 7780150)1, 2, 9 Romana S.P.... Bernard O.A. (1995)
- Fusion of PDGF receptor beta to a novel ets-like gene, tel, in chronic myelomonocytic leukemia with t(5;12) chromosomal translocation. (PubMed id 8168137)1, 2, 9 Golub T.R.... Gilliland D.G. (1994)
- Genome-wide analysis of genetic alterations in acute lymphoblastic leukaemia. (PubMed id 17344859)1, 2 Mullighan C.G.... Downing J.R. (2007)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- The histone deacetylase 9 gene encodes multiple protein isoforms. (PubMed id 12590135)1, 2 Petrie K....Zelent A. (2003)
|
External Searches for ETV6 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
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Genome Databases showing ETV6 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
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Other Databases showing ETV6 gene
(According to HUGE)
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Specialized Databases showing ETV6 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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| Patent Information for ETV6 gene:
Search GeneIP for patents involving ETV6
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
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Products
for ETV6 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
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| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for ETV6 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for ETV6 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for ETV6 | | | OriGene Protein Over-expression Lysate for ETV6 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for ETV6 | | OriGene 3'-UTR Clone for ETV6 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ETV6 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ETV6 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | OriGene Purified Protein for ETV6 | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for ETV6 | | OriGene Custom Protein Services for ETV6 | | | OriGene Custom Immunoassay Development | | |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat ETV6 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing ETV6 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ETV6 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ETV6 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ETV6 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ETV6 |
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| | | | Search Tocris compounds for ETV6 |
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 | | | ETV6 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ETV6 |
|  |  |  | | | | Search ThermoFisher Antibodies for ETV6 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ETV6 |
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