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ETV6 Gene

protein-coding GIFtS: 62

GC12P011694

ets variant 6
(Previous name: ets variant gene 6 (TEL oncogene) )
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
About This Section

Aliases
TEL ^¹, ², ³, ⁵
TEL/ABL ^²
TEL1 ^³
Tel ^³

Descriptions
ETS translocation variant 6 ^³
ETS-related protein Tel1 ^³
TEL1 oncogene ^²
ets variant 6 ^²
ets variant gene 6 (TEL oncogene) ^¹, ²

External Ids
HGNC: 3495¹
Entrez Gene: 2120²
UniProtKB: P41212³
Ensembl: ENSG00000139083⁷

Search outside databases for aliases for ETV6 gene

Previous GC identifers: GC12P011530 GC12P011947 GC12P011703

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

EntrezGene summary for ETV6:

This gene encodes an ETS family transcription factor. The product of this gene contains two

functional domains: a N-terminal pointed (PNT) domain that is involved in protein-protein

interactions with itself and other proteins, and a C-terminal DNA-binding domain. Gene knockout

studies in mice suggest that it is required for hematopoiesis and maintenance of the developing

vascular network. This gene is known to be involved in a large number of chromosomal

rearrangements associated with leukemia and congenital fibrosarcoma. [provided by RefSeq]

UniProtKB/Swiss-Prot: ETV6_HUMAN, P41212

Function: Transcriptional repressor; binds to the DNA sequence 5'-CCGGAAGT-3'

Gene Wiki entry for ETV6

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the ETV6 gene

Entrez Gene cytogenetic band: 12p13 Ensembl cytogenetic band: 12p13.2 HGNC cytogenetic band: 12p13

ETV6 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 12 GeneLoc Exon Structure

GeneLoc location for GC12P011694: (about GC identifiers)

Start:	11,694,055 bp from pter
End:	11,939,603 bp from pter
Size:	245,549 bases
Orientation:	plus strand

RefSeq DNA sequence:

NC_000012.10 NT_009714.16

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
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UniProtKB/Swiss-Prot: ETV6_HUMAN, P41212 (See protein sequence)

Recommended Name: Transcription factor ETV6

Size: 452 amino acids; 53000 Da

Subunit: Can form homodimers or heterodimers with TEL2 or FLI1. Interacts with L3MBTL and HDAC9

Subcellular location: Nucleus

PDB structures from and Proteopedia :

1JI7 (3D)

1LKY (3D)

2DAO (3D)

2QB0 (3D)

2QB1 (3D)

Secondary accessions: A3QVP6 Q9UMF6 Q9UMF7 Q9UMG0

Post-translational modifications:

Phosphorylated¹

Phosphorylation of Ser-257 by MAPK14 (p38) inhibits ETV6 transcriptional repression¹

View phosphorylation sites using PhosphoSite²

REFSEQ proteins: NP_001978.1

ENSEMBL proteins:

ENSP00000379658 ENSP00000266427 ENSP00000379656

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Browse Purified and Recombinant Proteins at Millipore
	Browse Human Recombinant Proteins at Sigma-Aldrich
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Recombinant Proteins from Abcam (ETV6 / Tel )
	Human Recombinant Proteins from Abnova (ETV6)

OriGene Purified Recombinant Human Protein: ETV6

3 Gene Ontology (GO) cellular component terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005634	nucleus	IEA	--
GO:0005730	nucleolus	IDA	18029348
GO:0005737	cytoplasm	IDA	18029348

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Antibodies for ETV6:

	Browse Antibodies Central at Invitrogen
	Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	Sigma-Aldrich Antibodies for ETV6
	Browse R&D Systems for Antibodies
	Antibodies from Abcam (ETV6 / Tel ), each with their Abpromise^SM
	Monoclonal and Polyclonal Antibodies from Abnova (ETV6)
	Novus Biologicals Antibodies for ETV6

Assays for ETV6:

	Browse Invitrogen for biochemical assays
	Browse Kits and Assays available from Millipore
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

Graphical View of Domain Structure for InterPro Entry P41212

ProtoNet protein and cluster: P41212

1 Blocks protein family: IPB003118 Sterile alpha motif (SAM)/Pointed domain

UniProtKB/Swiss-Prot: ETV6_HUMAN, P41212

Similarity: Belongs to the ETS family

Similarity: Contains 1 ETS DNA-binding domain

Similarity: Contains 1 PNT (pointed) domain

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (ETV6)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (ETV6)

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_001987

Applied Biosystems Silencer® siRNAs for ETV6

Sigma-Aldrich siRNA for ETV6

Sigma-Aldrich shRNA for ETV6

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Browse Clone Ranger at Invitrogen for clones
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clone in CMV expression vector: NM_001987
Myc/DDK tagged cDNA clone in CMV expression vector: NM_001987
untagged cDNA clone in CMV expression vector: NM_001987

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_001987

UniProtKB/Swiss-Prot: ETV6_HUMAN, P41212

Function: Transcriptional repressor; binds to the DNA sequence 5'-CCGGAAGT-3'

Genatlas biochemistry entry for ETV6:

ETS variant 6,transcriptional repressor,required for hematopoiesis in bone marrow,involved in

chronic myelomonocytic leukemia (see CMML) with translocations t(5;12)(q33;p13),

t(10;12)(q24;p13);in CML with translocation t(9;12)(q34;p13);in ALL and in B cell precursor ALL

with favorable outcome and translocations t(5;12)(q31-q33;p12),t(9;12) (p24;p13),t(12.21)(p13;q22)

(see AML1),t(6;12)(q23;p13),(see STL),and in myelodysplasia and myeloproliferative disorders with

translocation t(3;12)(q26;p13),(1;12)(p13 or q31;p13) (14;12) (q11;p13) t(12;22)

(p13;q11),t(12;15) (p13;q25),t(12;13)(p13-q12),in acute myeloid leukemia with translocation (4;12)

(q11-q12;p13) (see CDX2) in congenital fibrosarcoma (CFS),in congenital mesoblastic nephroma and

in biphenotypic adult leukemia (BIPL),see MDS1,EVI1,also involved in malignancies with hemizygous

deletions

11 MGI mutant phenotypes (inferred from 4 alleles) (MGI details for Etv6):

	embryogenesis	endocrine/exocrine gland	growth/size	hematopoietic system
immune system	lethality-prenatal/perinatal	life span-post-weaning/aging	normal	reproductive system
tumorigenesis

3 Gene Ontology (GO) molecular function terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0003700	transcription factor activity	TAS	7761424
GO:0005515	protein binding	IPI	12590135
GO:0043565	sequence-specific DNA binding	IEA	--

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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Gene Network Central^TM Interacting Genes and Proteins Network for ETV6

5/57 Interacting proteins for ETV6 (ENSP00000266427³ P41212¹) via UniProtKB, MINT, and/or STRING (see all 57 )

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
HDAC9	Q9UKV0¹	EBI-1372759, EBI-765444
UBE2I	ENSP00000348056³	STRING (score=.957)
JAK2	ENSP00000371067³	STRING (score=.955)
L3MBTL	ENSP00000362227³	STRING (score=.955)
KAT5	ENSP00000340330³	STRING (score=.943)

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2 Gene Ontology (GO) biological process terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006350	transcription	IEA	--
GO:0006355	regulation of transcription, DNA-dependent	IEA	--

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(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences

Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for ETV6
1 Novoseek chemical compound relationship for ETV6 gene

Compound	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
tyrosine	48.36	36	15611931 (3), 8754809 (2), 10590083 (2), 11159536 (2) (see all 28)

About this table

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (ETV6)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (ETV6)

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_001987

Sigma-Aldrich siRNA for ETV6

Sigma-Aldrich shRNA for ETV6

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_001987

REFSEQ mRNAs for ETV6 gene:

NM_001987.4

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_001987

              OriGene GFP tagged cDNA clone in CMV expression vector: NM_001987
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_001987
                                 untagged cDNA clone in CMV expression vector: NM_001987

Additional cDNA sequence:

AK289441.1 BC020284.1 BC043399.1 BC061911.1 DQ451147.1 EU364772.1 U11732.1 Z35761.1

14 DOTS entries:

DT.215338 DT.114998 DT.411164 DT.70104091 DT.121174815 DT.65287167 DT.40131416 DT.75142931

DT.99991732 DT.121175075 DT.40208185 DT.95257518 DT.92063108 DT.97837384

24/225 AceView cDNA sequences (see all 225 ):

BQ003277 BQ430842 CB243807 BU630424 AA773253 AW663067 BU681757 AI123905

AA928496 BM683130 AI400044 Z40311 BU623106 BX105902 BX097078 N67347

AW027091 AW953495 AA983191 AA347200 AI268890 NM_001987 BU507161 BM967174

highest scoring ESTs for ETV6:

AI762695 AA132557 AA132682 AA205732 AA205762 AA262997 AA310270 AA310659 AA311547 AA370643

Unigene Cluster for ETV6:

Ets variant 6

Hs.504765 [show with all ESTs]

Unigene Representative Sequence: NM_001987

GeneLoc Exon Structure

3 Ensembl transcripts including schematic representations:

ENST00000396373 ENST00000266427 ENST00000396370

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
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ETV6 expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for ETV6

¹ / ² / ³

12 probe-sets matching ETV6 gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
55594_at²^{, 3}	U95-B	1	1.00	1.00	0.82	1.27	AI762695	1.00	1.00	1.00	1
38491_at²^{, 3}	U95-A	1	1.00	1.00	0.94	1.08	U11732	0.80	1.00	0.91	1
58239_at²^{, 3}	U95-B	1	1.00	1.00	0.93	1.29	H63489	0.80	1.00	0.91	1
1638_at²^{, 3}	U95-A	3	1.00	0.94	0.86	0.55	U11732	0.80	1.00	0.91	1
92032_at²^{, 3}	U95-D	1	0.31	1.00	0.14	0.50	AI628893	0.60	1.00	0.82	1
72124_at*²^{, 3}	U95-E	1	--	--	-0.41	0.93	T91205	0.80	1.00	0.91	1
235056_at²^{, 3}	U133-B	1	1.00	1.00	--	--	AV722693	0.80	1.00	0.91	1
205585_at²^{, 3}	U133-A	1	1.00	1.00	--	--	NM_001987	0.60	1.00	0.82	1
225764_at²^{, 3}	U133-B	1	1.00	1.00	--	--	AI762695	1.00	1.00	1.00	1
235056_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
205585_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
225764_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--

GeneDecks ETV6 for binary patterns associated with the probe-sets selected above

About GeneDecksing

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Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: CCAAGTGAAC

SOURCE GeneReport for Unigene cluster: Hs.504765
Expression variation in blood from EXPOLDB for ETV6
UniProtKB/Swiss-Prot: ETV6_HUMAN, P41212
Tissue specificity: Ubiquitous

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for ETV6 gene from 5/8 species (see all 8 )

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	ETV6¹	--	ets variant 6	94.58(n) 96.66(a)	486685 XM_543812.2 XP_543812.2
chimpanzee (Pan troglodytes)	ETV6¹	--	ets variant 6	99.63(n) 99.56(a)	473366 XM_528737.2 XP_528737.2
cow (Bos taurus)	ETV6¹	--	ets variant 6	92.63(n) 96.46(a)	504512 NM_001015514.2 NP_001015514.2
rat (Rattus norvegicus)	Etv6¹	--	ets variant 6	90.34(n) 94.91(a)	312777 NM_001037353.1 NP_001032430.1
mouse (Mus musculus)	Etv6^{1, 5}	6 (63.90 cM)⁵	ets variant gene 6 (TEL oncogene)^{1, 5}	90.29(n)¹ 91.2(a)¹	14011¹ NM_007961.3¹ NP_031987.3¹ AI481701⁵ AK035231⁵ (see all 16)

About this table Species with no ortholog for ETV6

ENSEMBL Gene Tree for ETV6

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

Paralogs for ETV6 gene

ELK4² ETV7²

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

10/1696 NCBI SNPs in ETV6 are shown (see all 1696 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 605)

AB	SNP ID	Valid	Chr 12 pos	Sequence	Recs	AA Chg	Type	More	Recs	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--			--
	rs1062298^1,2	A,C,F,H,O	11936531(+)	`AGTGTG/TTGCCC`	1	--	ut3¹ ese³		7	MN EA WA NA	622
	rs2710278^1,2	A,C,F,H,O	11936452(-)	`ACTTTA/GAAAAA`	1	--	ut3¹ ese³		7	NA EU EA WA	562
	rs1573612^1,2	A,C,F,H	11938696(+)	`GAGGGT/CATCCC`	1	--	ut3¹		9	NA EA MN EU WA	1084
	rs1058028^1,2	A,C,F,H	11935462(+)	`GGGCAT/CGAGCC`	1	--	ut3¹ ese³		8	MN NA EU EA WA	746
--	rs10772497^1,2	A,C,F,H	11692392(+)	`GTTCCC/TATCAT`	1	--	ng5¹		4	EU EA WA	412
	rs1051782^1,2	A,C,F,H	11939040(+)	`CCTGTG/CTGGCT`	1	--	ut3¹ ese³		5	MN EU EA WA	596
--	rs1573613^1,2	A,C,F,H	11938885(+)	`TTCACT/CGCCTA`	1	--	ut3¹ ese³		5	MN EU EA WA	596
	rs1051779^1,2	A,C,F	11938683(+)	`CCTTTG/AGGGAG`	1	--	ut3¹		1	MN	184
	rs2541137^1,2	A,C,F	11692476(-)	`GACTTG/TTACAC`	1	--	ng5¹		4	NA EA	362
	rs2156932^1,2	C,F,H	11938544(+)	`TAGCCA/GGGCAG`	1	--	ut3¹		3	EA WA	298

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HapMap Linkage Disequilibrium images for ETV6 (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
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OMIM: 600618 disorders: 601626

UniProtKB/Swiss-Prot: ETV6_HUMAN, P41212

A chromosomal aberration involving ETV6 is found in a form of chronic myelomonocytic

leukemia (CMML). Translocation t(5;12)(q33;p13) with PDGFRB. It is characterized by abnormal

clonal myeloid proliferation and by progression to acute myelogenous leukemia (AML)

Chromosomal aberrations involving ETV6 are found in a form of acute myeloid leukemia

(AML). Translocation t(12;22)(p13;q11) with MN1; translocation t(4;12)(q12;p13) with CHIC2

Chromosomal aberrations involving ETV6 are found in childhood acute lymphoblastic leukemia

(ALL). Translocations t(12;21)(p12;q22) and t(12;21)(p13;q22) with RUNX1/AML1

A chromosomal aberration involving ETV6 is found in a form of pre-B acute myeloid

leukemia. Translocation t(9;12)(p24;p13) with JAK2

A chromosomal aberration involving ETV6 may be a cause of myelodysplastic syndrome (MDS)

with basophilia. Translocation t(5;12)(q31;p13) with ACSL6

A chromosomal aberration involving ETV6 may be a cause of acute eosinophilic leukemia

(AEL). Translocation t(5;12)(q31;p13) with ACSL6

A chromosomal aberration involving ETV6 is a cause of myelodysplastic syndrome (MDS).

Translocation t(1;12)(p36.1;p13) with MDS2

A chromosomal aberration involving ETV6 is a cause in many instances of chronic

myeloproliferative disorder with eosinophilia (MPE) [MIM:131440]. Translocation t(5;12) with

PDGFRB on chromosome 5 creating an ETV6-PDGFRB fusion protein

Defects in ETV6 are a cause of acute myelogenous leukemia (AML) [MIM:601626]. AML is a

malignant disease in which hematopoietic precursors are arrested in an early stage of development

A chromosomal aberration involving ETV6 is a cause of acute lymphoblastic leukemia.

Translocation t(9;12)(p13;p13) with PAX5

10/36 Novoseek disease relationships for ETV6 gene (see all 36 )

Disease	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
lymphoblastic leukemia acute childhood	88.11	23	9264370 (2), 9373267 (2), 18445843 (1), 18281529 (1) (see all 17)
leukemogenesis	83.78	20	16038737 (2), 15806161 (1), 18728978 (1), 11157492 (1) (see all 16)
lymphoblastic leukemia acute	83.50	28	12764377 (2), 16490598 (2), 7795247 (1), 9204978 (1) (see all 24)
leukemia	76.59	68	17069581 (3), 16643428 (3), 9060558 (3), 8754809 (2) (see all 49)
hematologic malignancies	73.71	25	9454771 (3), 9523197 (2), 7795247 (1), 11347199 (1) (see all 15)
myelodysplastic syndromes	68.43	17	18476590 (2), 9171997 (2), 8695816 (2), 16757412 (2) (see all 11)
leukemia myelomonocytic chronic	67.91	3	9031109 (1), 7761424 (1), 8168137 (1)
chromosomal aberrations	63.87	4	8695816 (1), 9365838 (1), 10557049 (1)
nephroma mesoblastic	63.13	1	11743047 (1)
t-all	61.89	4	9305598 (2), 17972957 (1)

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1 PharmGKB disease relationship for ETV6 gene

Disease	PharmGKB Relations	PubMed IDs for articles supporting these relationships
ALL (acute lymphoblastic leukemia)	FA GN	15142881

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Human Genome Epidemiology Navigator: ETV6 (1 document)

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
About This Section

10/291 PubMed articles for ETV6 gene (see all 291 ):

Somatic heterozygous mutations in ETV6 (TEL) and frequent absence of ETV6 protein in acute myeloid leukemia. (PubMed id 15806161)^{1, 3, 4} Barjesteh van Waalwijk van Doorn-Khosrovani S.... Delwel R. (2005)
The human L(3)MBT Polycomb group protein is a transcriptional repressor and interacts physically and functionally with TEL (ETV6). (PubMed id 12588862)^{1, 3, 4} Boccuni P.... Nimer S.D. (2003)
Functional regulation of TEL by p38-induced phosphorylation. (PubMed id 12435397)^{1, 3, 4} Arai H.... Mitani K. (2002)
Genomic organization of TEL: the human ETS-variant gene 6. (PubMed id 8743990)^{1, 3, 4} Baens M.... Marynen P. (1996)
Fusion of the TEL gene on 12p13 to the AML1 gene on 21q22 in acute lymphoblastic leukemia. (PubMed id 7761424)^{1, 3, 4} Golub T.R.... Gilliland D.G. (1995)
The t(12;21) of acute lymphoblastic leukemia results in a tel-AML1 gene fusion. (PubMed id 7780150)^{1, 3, 4} Romana S.P.... Bernard O.A. (1995)
Fusion of PDGF receptor beta to a novel ets-like gene, tel, in chronic myelomonocytic leukemia with t(5;12) chromosomal translocation. (PubMed id 8168137)^{1, 3, 4} Golub T.R.... Gilliland D.G. (1994)
Genome-wide analysis of genetic alterations in acute lymphoblastic leukaemia. (PubMed id 17344859)^{3, 4} Mullighan C.G.... Downing J.R. (2007)
Acute lymphoblastic leukemia with TEL-AML1 fusion has lower expression of genes involved in purine metabolism and lower de novo purine synthesis. (PubMed id 15142881)^{3, 7} Zaza G....Evans W.E. (2004)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{3, 4} Gerhard D.S....Malek J. (2004)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
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Entrez Gene: 2120	HGNC: 3495	AceView: ETV6	Ensembl:ENSG00000139083	euGenes: HUgn2120
ECgene: ETV6	H-InvDB: ETV6

(According to HUGE)
About This Section

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
ATLAS Chromosomes in Cancer entry for ETV6	Genetics and Cytogenetics in Oncology and Haematology

Licensable Technologies for ETV6
(Available from WIS Yeda, Salk, Tufts)

About This Section

(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section

Products for ETV6:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for ETV6-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for ETV6		Antibodies for ETV6
	Explore super-pooled esiRNAs		Browse proteins at Sigma-Aldrich
	Lentivirus-delivered shRNAs for ETV6		Browse small molecules at Sigma-Aldrich
	"Your Favorite Gene" Pathways		feedback

	Antibodies		Primer Pairs
	Cell Culture Products		ELISAs
	Flow Cytometry Kits		Protease Activity Assays & Reagents
	Cell Selection/Detection Kits & Reagents		ELISA/Assay Development Kits & Reagents
	Multiplex/Array Assay Kits & Reagents		ELISpot Kits & Development Modules
	Recombinant & Natural Proteins

	Recombinant Proteins (ETV6)
	Antibodies (ETV6)
	Chimera RNAi (ETV6)
	Custom Service for Mouse Mab
	Custom Service for Rabbit Pab from Full-length Protein

Search for Antibodies & Assays

	Recombinant Proteins (ETV6 / Tel )
	Antibodies (ETV6 / Tel )

	Tagged/untagged cDNA clones
	Validated SYBR primer pairs
	Purified proteins from HEK293T cells
	Western blot validated antibodies
	shRNA in GFP-retroviral vector

Search Tocris compounds for ETV6

Search www.enzolifesicences.com for proteins, assays, substrates, inhibitors & antibodies

Antibodies for ETV6

GeneCards Homepage - Last full update: 2 Jul 2009 Incremental update: 13 Oct 2009

Random Gene From GIFtS :

about GIFtS

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Developed at the Crown Human Genome Center & Weizmann Institute of Science

The GeneCards Human Gene Database: Copyright © 1996-2009, Weizmann Institute of Science. All Rights Reserved.
ETV6 Gene at Home site.
Version 2.41.1
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ETV6 Gene

protein-coding GIFtS: 62

Aliases &
Descriptions
for ETV6

Summaries
for ETV6

Genomic Location
for ETV6

Proteins
for ETV6

Protein Domains/
Families
for ETV6

Gene Function
for ETV6

Pathways & Interactions
for ETV6

Drugs & Compounds
for ETV6

Transcripts
for ETV6

Expression
for ETV6

Orthologs
for ETV6

Paralogs
for ETV6

SNPs/Variants
for ETV6

Disorders & Mutations
for ETV6

Medical News
for ETV6

Publications
for ETV6

Search for ETV6

Genome Databases showing ETV6

Other Databases showing ETV6

Specialized Databases showing ETV6

Licensable Technologies
for ETV6

Services
for ETV6

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

ETV6 Gene

protein-coding GIFtS: 62

Aliases & Descriptionsfor ETV6

Summariesfor ETV6

Genomic Locationfor ETV6

Proteinsfor ETV6

Protein Domains/Familiesfor ETV6

Gene Functionfor ETV6

Pathways & Interactionsfor ETV6

Drugs & Compoundsfor ETV6

Transcriptsfor ETV6

Expression for ETV6

Orthologsfor ETV6

Paralogsfor ETV6

SNPs/Variantsfor ETV6

Disorders & Mutationsfor ETV6

Medical Newsfor ETV6

Publicationsfor ETV6

Search for ETV6

Genome Databases showing ETV6

Other Databases showing ETV6

Specialized Databases showing ETV6

Licensable Technologiesfor ETV6

Servicesfor ETV6

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for ETV6

Summaries
for ETV6

Genomic Location
for ETV6

Proteins
for ETV6

Protein Domains/
Families
for ETV6

Gene Function
for ETV6

Pathways & Interactions
for ETV6

Drugs & Compounds
for ETV6

Transcripts
for ETV6

Expression
for ETV6

Orthologs
for ETV6

Paralogs
for ETV6

SNPs/Variants
for ETV6

Disorders & Mutations
for ETV6

Medical News
for ETV6

Publications
for ETV6

Licensable Technologies
for ETV6

Services
for ETV6