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Aliases for ETV5 Gene

Aliases for ETV5 Gene

  • Ets Variant 5 2 3
  • Ets-Related Protein ERM 3 4
  • Ets-Related Molecule 2 3
  • ERM 3 4
  • Ets Variant Gene 5 (Ets-Related Molecule) 2

External Ids for ETV5 Gene

Previous GeneCards Identifiers for ETV5 Gene

  • GC03M182555
  • GC03M187021
  • GC03M187166
  • GC03M187085
  • GC03M187246
  • GC03M185764
  • GC03M183174

Summaries for ETV5 Gene

GeneCards Summary for ETV5 Gene

ETV5 (Ets Variant 5) is a Protein Coding gene. Diseases associated with ETV5 include sertoli cell-only syndrome. Among its related pathways are Transcriptional misregulation in cancer and Androgen receptor signaling pathway. GO annotations related to this gene include transcription factor activity, sequence-specific DNA binding and transcription regulatory region DNA binding. An important paralog of this gene is ETV2.

UniProtKB/Swiss-Prot for ETV5 Gene

  • Binds to DNA sequences containing the consensus nucleotide core sequence 5-GGAA.-3.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ETV5 Gene

Genomics for ETV5 Gene

Regulatory Elements for ETV5 Gene

Transcription factor binding sites by QIAGEN in the ETV5 gene promoter:

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for ETV5 Gene

Chromosome:
3
Start:
186,046,308 bp from pter
End:
186,110,318 bp from pter
Size:
64,011 bases
Orientation:
Minus strand

Genomic View for ETV5 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ETV5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ETV5 Gene

Proteins for ETV5 Gene

  • Protein details for ETV5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P41161-ETV5_HUMAN
    Recommended name:
    ETS translocation variant 5
    Protein Accession:
    P41161
    Secondary Accessions:
    • A6NH46
    • B7Z7D7
    • Q6IBN5

    Protein attributes for ETV5 Gene

    Size:
    510 amino acids
    Molecular mass:
    57838 Da
    Quaternary structure:
    • Interacts (via C-terminal) with ZMYM5 (via N-terminal 120 amino acid region).

    Three dimensional structures from OCA and Proteopedia for ETV5 Gene

    Alternative splice isoforms for ETV5 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ETV5 Gene

Proteomics data for ETV5 Gene at MOPED

Post-translational modifications for ETV5 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ETV5 Gene

Antibody Products

No data available for DME Specific Peptides for ETV5 Gene

Domains & Families for ETV5 Gene

Gene Families for ETV5 Gene

Protein Domains for ETV5 Gene

Suggested Antigen Peptide Sequences for ETV5 Gene

Graphical View of Domain Structure for InterPro Entry

P41161

UniProtKB/Swiss-Prot:

ETV5_HUMAN :
  • Contains 1 ETS DNA-binding domain.
  • Belongs to the ETS family.
Domain:
  • Contains 1 ETS DNA-binding domain.
Family:
  • Belongs to the ETS family.
genes like me logo Genes that share domains with ETV5: view

Function for ETV5 Gene

Molecular function for ETV5 Gene

GENATLAS Biochemistry:
ETS variant 5,transcription factor of the ETS family,divergent member of the winged helix-turn-helix superfamily,expressed in brain,placenta and other tissues involved in development
UniProtKB/Swiss-Prot Function:
Binds to DNA sequences containing the consensus nucleotide core sequence 5-GGAA.-3.

Gene Ontology (GO) - Molecular Function for ETV5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000977 RNA polymerase II regulatory region sequence-specific DNA binding IMP 15857832
GO:0001228 transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding IMP 15857832
GO:0003677 DNA binding TAS 8152800
GO:0003700 transcription factor activity, sequence-specific DNA binding IDA 19443906
GO:0005515 protein binding IPI 17126306
genes like me logo Genes that share ontologies with ETV5: view
genes like me logo Genes that share phenotypes with ETV5: view

Animal Models for ETV5 Gene

MGI Knock Outs for ETV5:

Animal Model Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ETV5

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targets and HOMER Transcription for ETV5 Gene

Localization for ETV5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ETV5 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ETV5 Gene COMPARTMENTS Subcellular localization image for ETV5 gene
Compartment Confidence
nucleus 5

Gene Ontology (GO) - Cellular Components for ETV5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA 19443906
genes like me logo Genes that share ontologies with ETV5: view

Pathways & Interactions for ETV5 Gene

genes like me logo Genes that share pathways with ETV5: view

Pathways by source for ETV5 Gene

SIGNOR curated interactions for ETV5 Gene

Is activated by:
Is inactivated by:

Gene Ontology (GO) - Biological Process for ETV5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006355 regulation of transcription, DNA-templated --
GO:0006366 transcription from RNA polymerase II promoter IMP 15857832
GO:0007274 neuromuscular synaptic transmission IEA --
GO:0007626 locomotory behavior IEA --
GO:0030154 cell differentiation IBA --
genes like me logo Genes that share ontologies with ETV5: view

Drugs & Compounds for ETV5 Gene

(2) Drugs for ETV5 Gene - From: NovoSeek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Hyaluronan Approved Pharma 328
threonine Nutra 16

(1) Additional Compounds for ETV5 Gene - From: NovoSeek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
phosphoinositide
genes like me logo Genes that share compounds with ETV5: view

Transcripts for ETV5 Gene

Unigene Clusters for ETV5 Gene

Ets variant 5:
Representative Sequences:

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ETV5

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ETV5 Gene

No ASD Table

Relevant External Links for ETV5 Gene

GeneLoc Exon Structure for
ETV5
ECgene alternative splicing isoforms for
ETV5

Expression for ETV5 Gene

mRNA expression in normal human tissues for ETV5 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

SOURCE GeneReport for Unigene cluster for ETV5 Gene Hs.43697

mRNA Expression by UniProt/SwissProt for ETV5 Gene

P41161-ETV5_HUMAN
Tissue specificity: Ubiquitous
genes like me logo Genes that share expression patterns with ETV5: view

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression and Protein tissue co-expression partners for ETV5 Gene

Orthologs for ETV5 Gene

This gene was present in the common ancestor of animals.

Orthologs for ETV5 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia ETV5 35
  • 93.71 (n)
  • 97.64 (a)
ETV5 36
  • 97 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ETV5 35
  • 93.27 (n)
  • 96.67 (a)
ETV5 36
  • 90 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Etv5 35
  • 90.07 (n)
  • 95.49 (a)
Etv5 16
Etv5 36
  • 95 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia ETV5 35
  • 99.41 (n)
  • 99.41 (a)
ETV5 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Etv5 35
  • 89.74 (n)
  • 94.71 (a)
oppossum
(Monodelphis domestica)
Mammalia ETV5 36
  • 88 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia ETV5 36
  • 74 (a)
OneToOne
chicken
(Gallus gallus)
Aves ETV5 35
  • 78.59 (n)
  • 84.19 (a)
ETV5 36
  • 84 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia ETV5 36
  • 84 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii Dr.11545 35
etv5a 35
  • 65.71 (n)
  • 65.98 (a)
etv5a 36
  • 63 (a)
OneToMany
etv5b 36
  • 60 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta Ets96B 37
  • 87 (a)
Ets96B 36
  • 23 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 20 (a)
ManyToMany
Species with no ortholog for ETV5:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ETV5 Gene

ENSEMBL:
Gene Tree for ETV5 (if available)
TreeFam:
Gene Tree for ETV5 (if available)

Paralogs for ETV5 Gene

Paralogs for ETV5 Gene

(7) SIMAP similar genes for ETV5 Gene using alignment to 7 proteins:

genes like me logo Genes that share paralogs with ETV5: view

Variants for ETV5 Gene

Sequence variations from dbSNP and Humsavar for ETV5 Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type MAF
rs74607912 -- 186,100,770(+) ATTTG(A/G)TATGG intron-variant
rs74607992 -- 186,052,307(+) GCGAT(G/T)ATTCA intron-variant
rs74609221 -- 186,083,655(+) AAAAC(A/G)TCTTA intron-variant
rs74846175 -- 186,109,514(+) CTCTC(C/T)CGACT upstream-variant-2KB
rs74870380 -- 186,084,514(+) CGATG(A/G)GCCAG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ETV5 Gene

Variant ID Type Subtype PubMed ID
esv2665875 CNV Deletion 23128226
esv2726328 CNV Deletion 23290073

Variation tolerance for ETV5 Gene

Residual Variation Intolerance Score: 31.17% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.47; 43.40% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ETV5 Gene

HapMap Linkage Disequilibrium report
ETV5
Human Gene Mutation Database (HGMD)
ETV5

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ETV5 Gene

Disorders for ETV5 Gene

MalaCards: The human disease database

(1) MalaCards diseases for ETV5 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
sertoli cell-only syndrome
  • del castillo syndrome
- elite association
Search ETV5 in MalaCards View complete list of genes associated with diseases

Relevant External Links for ETV5

Genetic Association Database (GAD)
ETV5
Human Genome Epidemiology (HuGE) Navigator
ETV5
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ETV5
genes like me logo Genes that share disorders with ETV5: view

No data available for UniProtKB/Swiss-Prot and Genatlas for ETV5 Gene

Publications for ETV5 Gene

  1. Molecular cloning and characterization of human ERM, a new member of the Ets family closely related to mouse PEA3 and ER81 transcription factors. (PMID: 8152800) Monte D. … Stehelin D. (Oncogene 1994) 2 23 67
  2. Organizing the cell cortex: the role of ERM proteins. (PMID: 20308985) Fehon R.G. … Bretscher A. (Nat. Rev. Mol. Cell Biol. 2010) 23 67
  3. Structural basis for CD44 recognition by ERM proteins. (PMID: 18753140) Mori T. … Hakoshima T. (J. Biol. Chem. 2008) 23 67
  4. ERM transcription factor contains an inhibitory domain which functions in sumoylation-dependent manner. (PMID: 18243147) Degerny C. … Baert J.L. (Biochim. Biophys. Acta 2008) 23 67
  5. ERM proteins regulate growth cone responses to Sema3A. (PMID: 18651636) Mintz C.D. … Benson D.L. (J. Comp. Neurol. 2008) 23 67

Products for ETV5 Gene

Sources for ETV5 Gene

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