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Aliases & Descriptions for ETV5
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc
, and/or 7Ensembl,
8miRBase) About This Section
|
| | | Descriptions |
|---|
| Ets-related protein ERM 3 | | ets variant 5 2 | | ets variant gene 5 (ets-related molecule) 1, 2 | | ets-related molecule 2 |
|
| | Search outside databases for aliases for ETV5 genePrevious GC identifers: GC03M182555 GC03M187021 GC03M187166 GC03M187085 |
Summaries for ETV5(According to Entrez Gene,
Wikipedia's
Gene Wiki,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
| UniProtKB/Swiss-Prot: ETV5_HUMAN, P41161Function: Binds to DNA sequences containing the consensus nucleotide core sequence GGAA |
Genomic Location for ETV5
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to
UCSC and
Ensembl,
Transcription factor binding sites according to
SABiosciences) About This Section
| Genomic View: UCSC Golden Path with GeneCards custom track
Transcription factor binding sites upstream to the ETV5 gene 
Entrez Gene cytogenetic band: 3q28 Ensembl cytogenetic band: 3q27.2 HGNC cytogenetic band: 3q28ETV5 Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different)
 GeneLoc gene densities for chromosome 3 GeneLoc Exon Structure GeneLoc location for GC03M187246:
(about GC identifiers)
Start:
|
187,246,804 bp from pter |
End:
|
187,309,571 bp from pter |
Size:
|
62,768 bases |
Orientation:
|
minus strand |
RefSeq DNA sequence:- NC_000003.10 NT_005612.15
| Proteins for ETV5
(According to
1UniProtKB,
and/or Ensembl,
Phosphorylation sites according to 2Phosphosite,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from Invitrogen,
Millipore,
Sigma-Aldrich,
R&D Systems,
Enzo Life Sciences,
Abnova,
OriGene and/or,
Abcam,
Biochemical Assays by
Invitrogen,
Millipore,
R&D Systems,
Cell Signaling Technology, and/or
Enzo Life Sciences,
Ontologies according to Gene
Ontology Consortium 01 Apr 2009 and
Entrez Gene,
Antibodies by Invitrogen,
Millipore,
Sigma-Aldrich,
R&D Systems,
Cell Signaling Technology,
Abcam,
Abnova, and/or
Novus Biologicals)
About This Section
| UniProtKB/Swiss-Prot: ETV5_HUMAN, P41161 (See
protein sequence)Recommended Name: ETS translocation variant 5 Size: 510 amino acids; 57838 Da
Subcellular location: Nucleus
Mass spectrometry: Mass=57837.98; Method=MALDI; Range=1-510; Source=PubMed:11840567;
Secondary accessions: A6NH46 Q6IBN5Post-translational modifications:
View phosphorylation sites using PhosphoSite2
REFSEQ proteins: NP_004445.1
ENSEMBL proteins: ENSP00000306894
Human Recombinant Proteins Browse Origene for full length recombinant human proteins expressed in human HEK293 cells 
1 Gene Ontology (GO) cellular component term (links to tree view): | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005634 | nucleus |
IEA | -- | About this table
Antibodies for ETV5: Assays for ETV5: | Protein
Domains/ Families for ETV5(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
| - Graphical View of Domain Structure for InterPro Entry P41161
ProtoNet protein and cluster: P41161 1 Blocks protein family: IPB006715 PEA3-type ETS-domain transcription factor
UniProtKB/Swiss-Prot: ETV5_HUMAN, P41161Similarity: Belongs to the ETS familySimilarity: Contains 1 ETS DNA-binding domain | Gene Function for ETV5
(According to MGI Jun 06 2009, UniProtKB,
IUBMB,and/or Genatlas,
shRNA from
OriGene,
Sigma-Aldrich, RNAi from
Sigma-Aldrich,
RNAi Products,
Clones, and
Q-PCR Products
from Invitrogen,
Millipore,
OriGene, and/or
Abnova,
siRNAs from
Applied Biosystems,
SYBR primers from OriGene,
Cell-based Assays from Millipore,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene.)
About This Section
|               OriGene 29mer shRNA kit in GFP-retroviral vector: NM_004454
Applied Biosystems Silencer® siRNAs for ETV5
Sigma-Aldrich siRNA for ETV5  Sigma-Aldrich shRNA for ETV5  Explore Sigma-Aldrich super-pooled esiRNAs 
              OriGene GFP tagged cDNA clone in CMV expression vector: NM_004454                                  Myc/DDK tagged cDNA clone in CMV expression vector: NM_004454                                  untagged cDNA clone in CMV expression vector: NM_004454 
Primers: Browse
Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers               OriGene genome-wide validated SYBR primer pairs: NM_004454
UniProtKB/Swiss-Prot: ETV5_HUMAN, P41161Function: Binds to DNA sequences containing the consensus nucleotide core sequence GGAAGenatlas biochemistry entry for ETV5:ETS variant 5,transcription factor of the ETS family,divergent member of the winged helix-turn-helix superfamily,expressed in brain,placenta and other tissues involved in development2 MGI mutant phenotypes (inferred from 1 allele ) (MGI details for Etv5):
3 Gene Ontology (GO) molecular function terms (links to tree view): | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0003700 | transcription factor activity |
TAS | 8152800 | | GO:0016563 | transcription activator activity |
IEA | -- | | GO:0043565 | sequence-specific DNA binding |
IEA | -- | About this table | Pathways & Interactions for ETV5
(Pathways according to Invitrogen
(maps by GeneGo),
Millipore,
Cell Signaling Technology,
Sigma-Aldrich,
KEGG
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Proteins Network according to
SABiosciences,
Interactions according to 1UniProtKB,
2MINT, and/or
3STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene.)
About This Section
|
Gene Network CentralTM Interacting Genes and Proteins Network for ETV5 
--3 Gene Ontology (GO) biological process terms (links to tree view): | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0006355 | regulation of transcription, DNA-dependent |
IEA | -- | | GO:0009887 | organ morphogenesis |
IEA | -- | | GO:0045941 | positive regulation of transcription |
IEA | -- | About this table
|
Drugs & Compounds for ETV5(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
Sigma-Aldrich, Tocris Bioscience, and/or
Novoseek and Drugs according to
Enzo Life Sciences and/or
PharmGKB)
About This Section
|
Browse Tocris compounds for ETV5 2 Novoseek chemical compound relationships for ETV5 gene
About this table
2 PharmGKB drug compound relationships for ETV5 geneAbout this table
|
Transcripts for ETV5(GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 219 Homo sapiens; Jun 2 2009) or GenBank, RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
non coding RNAs according to
RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from Invitrogen,
Millipore, and/or
Abnova,
siRNAs from Applied Biosystems,
Sigma-Aldrich,
shRNA from
Sigma-Aldrich,
OriGene,
Tagged/untagged cDNA clones from
OriGene, Expression Assays from Applied Biosystems) About This Section
|               OriGene 29mer shRNA kit in GFP-retroviral vector: NM_004454
Sigma-Aldrich siRNA for ETV5  Sigma-Aldrich shRNA for ETV5  Explore Sigma-Aldrich super-pooled esiRNAs 
Applied Biosystems Silencer® siRNAs: NM_004454 REFSEQ mRNAs for ETV5 gene: NM_004454.2
Applied Biosystems TaqMan ® Gene Expression Assays: NM_004454               OriGene GFP tagged cDNA clone in CMV expression vector: NM_004454                                  Myc/DDK tagged cDNA clone in CMV expression vector: NM_004454                                  untagged cDNA clone in CMV expression vector: NM_004454  Additional cDNA sequence: AK301878.1 BC007333.2 BT006713.1 CR456767.1 EU314929.1 EU314930.1 EU314932.1 X76184.1 11 DOTS entries: DT.454608 DT.99947371 DT.75178777 DT.318278 DT.120850247 DT.120850280 DT.86841092 DT.91832400 DT.92431695 DT.92431699 DT.95173645 24/230 AceView cDNA sequences (see all 230
):AA503077 BT006713 AA137020 BM695686 BE549808 BM728510 R67394 AA369756 BU625642 AA303163 BQ217349 AL135307 AI677871 BQ639004 BM313678 BQ021275 BF195293 AW590683 AI342788 AI831482 BQ425245 AI829698 BM998404 AI348603
highest scoring ESTs for ETV5:BE270390 BE275849 BE276417 BE295187 BE407274 BE407853 BE408551 BF027517 BF306573 BG396936 Unigene Cluster for ETV5: Ets variant 5 Hs.43697 [show with all ESTs]Unigene Representative Sequence: NM_004454
GeneLoc Exon Structure
5 Alternative Splicing Database (ASD) splice patterns (SP) for ETV5
| ExUns: | 1 | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6 | ^ | 7 | ^ | 8 | ^ | 9 | ^ | 10 | ^ | 11a | · | 11b | · | 11c | ^ | 12 | ^ | 13 | ^ | 14 | ^ | 15 | |
| SP1: | |   | |   | |   | |   | |   | |   | |   | - |   | - |   | |   | - |   | |   | |   | |   | |   | |   | |   | |
| SP2: | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |
| SP3: | |   | |   | |   | |   | |   | |   | |   | - |   | - |   | |   | - |   | |   | |   | |   | |   | |   | |   | |
| SP4: | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | - |   | |   | |   | |   | |   | |   | |   | |
| SP5: | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   |
About this scheme
ECgene alternative splicing isoforms for ETV5
1 Ensembl transcript including schematic representation: ENST00000306376
|
Expression for ETV5
(Experimental results according to
1GeneNote
and GNF BioGPS,
probe sets-to-genes annotations according to
2GeneAnnot ,
3GeneTide ,
Sets of similar genes according to GeneDecks,
Electronic Northern calculations according to data from
UniGene (Build 219 Homo sapiens),
SAGE tags according to
CGAP,
plus additional links to
SOURCE, and/or
GNF
BioGPS, and/or
EXPOLDB, and/or
UniProtKB,
Expression Assays from
Applied Biosystems
)
About This Section
| ETV5 expression in normal and diseased human tissues
Applied Biosystems TaqMan ® Gene Expression Assays for ETV5
1 / 2 / 3 8 probe-sets matching ETV5 gene Data from
(Publications) and GNF BioGPS About these images About these images
CGAP SAGE TAG: CACCTCCCGG
SOURCE GeneReport for Unigene cluster: Hs.43697
Expression variation in blood from EXPOLDB for ETV5 UniProtKB/Swiss-Prot: ETV5_HUMAN, P41161Tissue specificity: Ubiquitous |
Orthologs for ETV5
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
and/or
5MGI Jun 06 2009,
with possible further links to
Flybase
and/or
WormBase,
Gene Trees according to Ensembl)
About This Section
|
Orthologs for ETV5 gene from 5/8 species (see all 8
)
About this table Species with no ortholog for ETV5
ENSEMBL Gene Tree for ETV5 | Paralogs for ETV5(Paralogs according to 1HomoloGene and 2Ensembl, Pseudogenes according to 3Pseudogene.org) About This Section
| Paralogs for ETV5 gene
- ETV42 ETV12
|
SNPs/Variants for ETV5(According to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE, and
UniProtKB,
Linkage Disequilibrium by HapMap,
Genotyping Reagents from
Applied Biosystems)
About This Section
|
HapMap Linkage Disequilibrium images for ETV5 (up to first 250kb)
|
Disorders & Mutations for ETV5
(in which this Gene is Involved, According to
OMIM, UniProtKB,
Novoseek, PharmGKB,
Genatlas, GeneTests,
Blood group antigen gene mutations by BGMUT,
HGMD, GAD,
HuGE Navigator,
BCGD,
and/or TGDB.)
About This Section
|
OMIM: 601600
5 Novoseek disease relationships for ETV5 gene
About this table
1 PharmGKB disease relationship for ETV5 geneAbout this table
|
Medical News for ETV5(Possibly Related Articles in
Doctor's Guide)
About This Section
| -- |
Publications for ETV5 (in
PubMed.
Associations of this gene to articles via
1Novoseek,
2HGNC,
3Entrez Gene,
4UniProtKB/Swiss-Prot,
5UniProtKB/TrEMBL,
6GAD, and/or
7PharmGKB)
About This Section
| 10/55 PubMed articles for ETV5 gene (see all 55
):- Molecular cloning and characterization of human ERM, a new member of the Ets family closely related to mouse PEA3 and ER81 transcription factors. (PubMed id 8152800)1, 2, 3, 4 Monte D.... Stehelin D. (1994)
- Genomic organization of the human ERM (ETV5) gene, a PEA3 group member of ETS transcription factors. (PubMed id 8661127)1, 3, 4 Monte D.... de Launoit Y. (1996)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)3, 4 Gerhard D.S....Malek J. (2004)
- Cluster analysis of an extensive human breast cancer cell line protein expression map database. (PubMed id 11840567)3, 4 Harris R.A....Zvelebil M.J. (2002)
- Regulation of hyaluronan binding by F-actin and colocalization of CD44 and phosphorylated ezrin/radixin/moesin (ERM) proteins in myeloid cells. (PubMed id 15652352)1, 3 Brown K.L....Johnson P. (2005)
- Assignment of the ERM gene (ETV5) coding for the ets-related protein to human chromosome band 3q28 by in situ hybridization. (PubMed id 8941378)1, 3 Protopopova M.V....Graphodatsky A.S. (1996)
- ITAM-based interaction of ERM proteins with Syk mediates signaling by the leukocyte adhesion receptor PSGL-1. (PubMed id 12387735)1, 3 Urzainqui A....Sanchez-Madrid F. (2002)
- Expression of the Ets transcription factor Erm is regulated through a conventional PKC signaling pathway in the Molt4 lymphoblastic cell line. (PubMed id 15620692)1, 3 T'sas F....de Launoit Y. (2005)
- Genome-wide association yields new sequence variants at seven loci that associate with measures of obesity. (PubMed id 19079260)3 Thorleifsson G....Stefansson K. (2009)
- Characterization of TMPRSS2:ETV5 and SLC45A3:ETV5 gene fusions in prostate cancer. (PubMed id 18172298)3 Helgeson B.E....Chinnaiyan A.M. (2008)
|
Search for ETV5
(in PubMed,
OMIM, and NCBI Bookshelf) About This Section
|
|
Genome Databases showing ETV5
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
and/or
H-InvDB)
About This Section
|
| Other Databases showing ETV5
(According to HUGE)
About This Section
| -- |
Specialized Databases showing ETV5(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL, Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot) About This Section
|
| About This Section
| --
| Services for ETV5(Reagents available from Applied Biosystems, Antibodies and assays by Cell
Signaling Technology, Abcam, Novus Biologicals, Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich, Enzo Life Sciences, and/or Tocris Bioscience) About This Section
| 
 Products for ETV5:

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Incremental update: 13 Oct 2009
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