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ETV5 Gene

protein-coding   GIFtS: 63
GCID: GC03M185764

Ets Variant 5

(Previous name: ets variant gene 5 (ets-related molecule))
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Ets Variant 51 2
ERM2 3 5
Ets-Related Molecule1 2
Ets-Related Protein ERM2 3
Ets Variant Gene 5 (Ets-Related Molecule)1
ETS Translocation Variant 52

External Ids:    HGNC: 34941   Entrez Gene: 21192   Ensembl: ENSG000002444057   OMIM: 6016005   UniProtKB: P411613   

Export aliases for ETV5 gene to outside databases

Previous GC identifers: GC03M182555 GC03M187021 GC03M187166 GC03M187085 GC03M187246 GC03M183174


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for ETV5 Gene:
ETV5 (ets variant 5) is a protein-coding gene. GO annotations related to this gene include transcription regulatory region DNA binding and sequence-specific DNA binding transcription factor activity. An important paralog of this gene is ETV1.

UniProtKB/Swiss-Prot: ETV5_HUMAN, P41161
Function: Binds to DNA sequences containing the consensus nucleotide core sequence GGAA




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000003.11  NC_018914.2  NT_005612.17  
Regulatory elements:
   Regulatory transcription factor binding sites in the ETV5 gene promoter:
         AML1a   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidETV5 promoter sequence
   Search Chromatin IP Primers for ETV5

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ETV5


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 3q28   Ensembl cytogenetic band:  3q27.2   HGNC cytogenetic band: 3q28

ETV5 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ETV5 gene location

GeneLoc information about chromosome 3         GeneLoc Exon Structure

GeneLoc location for GC03M185764:  view genomic region     (about GC identifiers)

Start:
185,764,097 bp from pter      End:
185,828,107 bp from pter
Size:
64,011 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: ETV5_HUMAN, P41161 (See protein sequence)
Recommended Name: ETS translocation variant 5  
Size: 510 amino acids; 57838 Da
Mass spectrometry: Mass=57837.98; Method=MALDI; Range=1-510; Source=PubMed:11840567;
Secondary accessions: A6NH46 Q6IBN5

Explore the universe of human proteins at neXtProt for ETV5: NX_P41161

Explore proteomics data for ETV5 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See ETV5 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_004445.1  
    ENSEMBL proteins: 
     ENSP00000306894   ENSP00000413755   ENSP00000399707   ENSP00000389707   ENSP00000412171  
     ENSP00000405157   ENSP00000388737   ENSP00000441737  

    ETV5 Human Recombinant Protein Products:

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    OriGene Protein Over-expression Lysate for ETV5
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    Novus Biologicals ETV5 Protein
    Novus Biologicals ETV5 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for ETV5

     
    Search eBioscience for Proteins for ETV5 

     
    antibodies-online proteins for ETV5 (4 products) 

     
    antibodies-online peptides for ETV5

    ETV5 Antibody Products:

    EMD Millipore Mono- and Polyclonal Antibodies for the study of ETV5
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    ETV5 Assay Products:

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    Cloud-Clone Corp. ELISAs for ETV5
    Cloud-Clone Corp. CLIAs for ETV5
    Search eBioscience for ELISAs for ETV5 
    antibodies-online kits for ETV5 (4 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    3 InterPro protein domains:
     IPR000418 Ets_dom
     IPR011991 WHTH_DNA-bd_dom
     IPR006715 ETS_PEA3_N

    Graphical View of Domain Structure for InterPro Entry P41161

    ProtoNet protein and cluster: P41161

    1 Blocks protein domain: IPB006715 PEA3-type ETS-domain transcription factor

    UniProtKB/Swiss-Prot: ETV5_HUMAN, P41161
    Similarity: Belongs to the ETS family
    Similarity: Contains 1 ETS DNA-binding domain


    Find genes that share domains with ETV5           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ETV5_HUMAN, P41161
    Function: Binds to DNA sequences containing the consensus nucleotide core sequence GGAA

         Genatlas biochemistry entry for ETV5:
    ETS variant 5,transcription factor of the ETS family,divergent member of the winged helix-turn-helix
    superfamily,expressed in brain,placenta and other tissues involved in development

         Gene Ontology (GO): 5 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000981sequence-specific DNA binding RNA polymerase II transcription factor activity IBA--
    GO:0003677DNA binding TAS8152800
    GO:0003700sequence-specific DNA binding transcription factor activity IDA19443906
    GO:0043565sequence-specific DNA binding IEA--
    GO:0044212transcription regulatory region DNA binding IDA19443906
         
    Find genes that share ontologies with ETV5           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for ETV5:
     Elongated cells 

         13 MGI mutant phenotypes (inferred from 4 alleles(MGI details for Etv5):
     behavior/neurological  cellular  craniofacial  embryogenesis  endocrine/exocrine gland 
     growth/size/body  limbs/digits/tail  mortality/aging  nervous system  renal/urinary system 
     reproductive system  respiratory system  skeleton 

    Find genes that share phenotypes with ETV5           About GenesLikeMe

    Animal Models:
         MGI mouse knock-outs for ETV5: Etv5tm1Kmm Etv5tm1.2Xsun

       genOway: Develop your customized and physiologically relevant rodent model for ETV5

    miRNA
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    miRTarBase miRNAs that target ETV5:
    hsa-mir-335-5p (MIRT017311)

    Block miRNA regulation of human, mouse, rat ETV5 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate ETV5 (see all 55):
    hsa-miR-136 hsa-miR-429 hsa-let-7a-2* hsa-miR-219-5p hsa-miR-764 hsa-miR-1183 hsa-miR-200b hsa-miR-497*
    SwitchGear 3'UTR luciferase reporter plasmidETV5 3' UTR sequence
    Inhib. RNA
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    OriGene RNAi products in human, mouse, rat for ETV5
    Predesigned siRNA for gene silencing in human, mouse, rat ETV5

    Gene Editing
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    Clone
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    GenScript: all cDNA clones in your preferred vector: ETV5 (NM_004454)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for ETV5
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ETV5

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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ETV5

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    eBioscience FlowRNA Probe Sets ( VA1-11754) for ETV5 


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    ETV5_HUMAN, P41161: Nucleus
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    cytosol3
    plasma membrane3

    Gene Ontology (GO): 1 cellular component term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA19443906

    Find genes that share ontologies with ETV5           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for ETV5 About    
    See pathways by source

    SuperPathContained pathways About
    1IL12-mediated signaling events
    Immune response IL 12 induced IFN gamma production0.33
    2Transcriptional misregulation in cancer
    Transcriptional misregulation in cancer
    3IL12 signaling mediated by STAT4
    IL12 signaling mediated by STAT4
    4FOXM1 transcription factor network
    FOXM1 transcription factor network
    5Androgen receptor signaling pathway
    Androgen receptor signaling pathway


    Find genes that share SuperPaths with ETV5           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 GeneGo (Thomson Reuters) Pathway for ETV5
        Immune response IL-12-induced IFN-gamma production

    3 BioSystems Pathways for ETV5
        Androgen receptor signaling pathway
    FOXM1 transcription factor network
    IL12 signaling mediated by STAT4


    1 Kegg Pathway  (Kegg details for ETV5):
        Transcriptional misregulation in cancer

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for ETV5
    Interactions:

        GeneGlobe Interaction Network for ETV5

    STRING Interaction Network Preview (showing 5 interactants - click image to see 16)

    Selected Interacting proteins for ETV5 (P411613 ENSP000003068944) via UniProtKB, MINT, STRING, and/or I2D (see all 16)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ARP102753, ENSP000003638224I2D: score=2 STRING: ENSP00000363822
    RFWD2Q8NHY23, ENSP000003566414I2D: score=1 STRING: ENSP00000356641
    UBCP0CG483, ENSP000003448184I2D: score=1 STRING: ENSP00000344818
    FOXM1ENSP000003423074STRING: ENSP00000342307
    STAT4ENSP000003512554STRING: ENSP00000351255
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 15):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006355regulation of transcription, DNA-templated ----
    GO:0006357regulation of transcription from RNA polymerase II promoter IBA--
    GO:0006366transcription from RNA polymerase II promoter IBA--
    GO:0007274neuromuscular synaptic transmission IEA--
    GO:0007610behavior ----

    Find genes that share ontologies with ETV5           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for ETV5

    3 Novoseek inferred chemical compound relationships for ETV5 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    hyaluronic acid 29.1 1 15326184 (1)
    phosphoinositide 25.3 2 15096511 (2)
    threonine 13.3 2 17075902 (1), 15652352 (1)



    Find genes that share compounds with ETV5           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for ETV5 gene: 
    NM_004454.2  

    Unigene Cluster for ETV5:

    Ets variant 5
    Hs.43697  [show with all ESTs]
    Unigene Representative Sequence: NM_004454
    15 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000306376(uc003fpy.3 uc003fpz.3) ENST00000434744 ENST00000480706
    ENST00000433149 ENST00000489830 ENST00000484223 ENST00000472868 ENST00000440773
    ENST00000421809 ENST00000413301 ENST00000422039 ENST00000476890 ENST00000475484
    ENST00000495808 ENST00000537818
    miRNA
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    Block miRNA regulation of human, mouse, rat ETV5 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate ETV5 (see all 55):
    hsa-miR-136 hsa-miR-429 hsa-let-7a-2* hsa-miR-219-5p hsa-miR-764 hsa-miR-1183 hsa-miR-200b hsa-miR-497*
    SwitchGear 3'UTR luciferase reporter plasmidETV5 3' UTR sequence
    Inhib. RNA
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    Primer
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    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat ETV5
      QuantiTect SYBR Green Assays in human, mouse, rat ETV5
      QuantiFast Probe-based Assays in human, mouse, rat ETV5
    Flow Cytometry
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    eBioscience FlowRNA Probe Sets ( VA1-11754) for ETV5 

    Additional mRNA sequence: 

    AK301878.1 BC007333.2 BT006713.1 CR456767.1 X76184.1 

    11 DOTS entries:

    DT.454608  DT.99947371  DT.75178777  DT.120850247  DT.120850280  DT.86841092  DT.91832400  DT.92431695 
    DT.92431699  DT.95173645  DT.318278 

    Selected AceView cDNA sequences (see all 230):

    BQ425245 CB105127 AA369756 BQ582031 BE549808 BG482720 BU625642 BM888448 
    AW590683 AA301189 AA219130 AI348603 AA258644 AL135307 BQ639004 F01802 
    BX439885 AI354807 BM728510 BQ217349 BM313943 BT006713 BQ614503 AI677871 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    ETV5 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CACCTCCCGG
    ETV5 Expression
    About this image


    ETV5 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 8) fully expand
     
     Neural Tube (Nervous System)    fully expand to see all 3 entries
             Metencephalon
     
     Testis (Reproductive System)    fully expand to see all 3 entries
             Spermatogonial Stem Cells Seminiferous Tubules
     
     Brain (Nervous System)    fully expand to see all 2 entries
             Cerebellum
             N2/LSB induced-cells
     
     Lung (Respiratory System)    fully expand to see all 2 entries
             Distal Lung Epithelial Cells Terminal Sacs
     
     Epithelial Cells
             Distal Lung Epithelial Cells Terminal Sacs
    ETV5 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    ETV5 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.43697

    UniProtKB/Swiss-Prot: ETV5_HUMAN, P41161
    Tissue specificity: Ubiquitous

        Custom PCR Arrays for ETV5
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ETV5

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for ETV5 gene from Selected species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Etv51 , 5 ets variant gene 51, 5 90.07(n)1
    95.49(a)1
      16 (13.30 cM)5
    1041561  NM_023794.21  NP_076283.21 
     223813095 
    chicken
    (Gallus gallus)
    Aves ETV51 ets variant 5 78.59(n)
    84.19(a)
      395749  XM_422651.3  XP_422651.2 
    lizard
    (Anolis carolinensis)
    Reptilia ETV56
    ets variant 5
    84(a)
    1 ↔ 1
    3(34199906-34249601)
    zebrafish
    (Danio rerio)
    Actinopterygii Dr.115452 Danio rerio mRNA similar to ets variant gene 5 (ets-related more 78.02(n)    BC048059.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Ets96B3 transcription factor 87(a)   96A22   --


    ENSEMBL Gene Tree for ETV5 (if available)
    TreeFam Gene Tree for ETV5 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for ETV5 gene
    ETV12  ETV32  ERF2  ETV3L2  ETS12  GABPA2  ETS22  ERG2  
    FEV2  ETV42  ETV22  FLI12  
    7 SIMAP similar genes for ETV5 using alignment to 7 protein entries:     ETV5_HUMAN (see all proteins):
    ETV1    FEV    TLS-ERG    ELK3    ETV2    ETV4
    DDX5-ETV4 fusion

    Find genes that share paralogs with ETV5           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for ETV5 (see all 1130)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 3 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs130632101,2
    C,F,H--185763735(+) ACTCGA/GAAGTC 1 -- ds50018Minor allele frequency- G:0.02EA NS NA 764
    rs1172790831,2
    C,F--185763794(+) TACACT/CTAAAA 1 -- ds50011Minor allele frequency- C:0.01EA 120
    rs1490347201,2
    --185763818(+) GAATTC/GGTGGC 1 -- ds50010--------
    rs1907628861,2
    --185763863(+) CACCAC/TTGGCT 1 -- ds50010--------
    rs1457408791,2
    --185763869(+) TGGCTA/GGGAAG 1 -- ds50010--------
    rs1822673831,2
    --185763885(+) CTCTCG/TACTTT 1 -- ds50010--------
    rs771515791,2
    C--185763893(+) TTTCCA/TCCTCT 1 -- ds50010--------
    rs774482091,2
    C,F--185763975(+) CTACCC/TTCGAT 1 -- ds50011Minor allele frequency- T:0.02EA 120
    rs1435526771,2
    C--185764049(+) GGGGG-/CTTTTG 1 -- ds50010--------
    rs1874377421,2
    --185764223(+) TCAAGC/GCTTTC 1 -- ut310--------

    HapMap Linkage Disequilibrium report for ETV5 (185764097 - 185828107 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for ETV5:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2665875CNV Deletion23128226
    esv2726328CNV Deletion23290073

    Human Gene Mutation Database (HGMD): ETV5
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing ETV5
    DNA2.0 Custom Variant and Variant Library Synthesis for ETV5

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 601600    OMIM disorders: --

    1 disease from the University of Copenhagen DISEASES database for ETV5:
    Renal agenesis

    Find genes that share disorders with ETV5           About GenesLikeMe

    5 Novoseek inferred disease relationships for ETV5 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    neurofibromatosis type 2 67.8 2 10567424 (1), 11368764 (1)
    schwannoma 30 1 11368764 (1)
    meningioma 25.3 1 11368764 (1)
    tumors 1.99 2 15699051 (1), 10567424 (1)
    melanoma 0 1 14704146 (1)

    Genetic Association Database (GAD): ETV5
    Human Genome Epidemiology (HuGE) Navigator: ETV5 (16 documents)

    Export disorders for ETV5 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for ETV5 gene, integrated from 10 sources (see all 89):
    (articles sorted by number of sources associating them with ETV5)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Molecular cloning and characterization of human ERM, a new member of the Ets family closely related to mouse PEA3 and ER81 transcription factors. (PubMed id 8152800)1, 2, 3, 9 Monte D.... Stehelin D. (Oncogene 1994)
    2. Genomic organization of the human ERM (ETV5) gene, a PEA3 group member of ETS transcription factors. (PubMed id 8661127)1, 2, 9 Monte D.... de Launoit Y. (Genomics 1996)
    3. Association analyses of 249,796 individuals reveal 18 new loci associated with body mass index. (PubMed id 20935630)1, 4 Speliotes E.K....Loos R.J. (Nat. Genet. 2010)
    4. Genetic susceptibility to obesity and related traits in childhood and adolescence: influence of loci identified by genome-wide association studies. (PubMed id 20724581)1, 4 den Hoed M....Loos R.J. (Diabetes 2010)
    5. Evaluating the discriminative power of multi-trait genetic risk scores for type 2 diabetes in a northern Swedish population. (PubMed id 20571754)1, 4 Fontaine-Bisson B....Franks P.W. (Diabetologia 2010)
    6. Are recently identified genetic variants regulating BMI in the general population associated with anorexia nervosa? (PubMed id 19746409)1, 4 Brandys M.K....Adan R.A. (Am. J. Med. Genet. B Neuropsychiatr. Genet. 2010)
    7. Cumulative effects and predictive value of common obesity-susceptibility variants identified by genome-wide association studies. (PubMed id 19812171)1, 4 Li S....Loos R.J. (Am. J. Clin. Nutr. 2010)
    8. Genetic markers of adult obesity risk are associated with greater early infancy weight gain and growth. (PubMed id 20520848)1, 4 Elks C.E....Ong K.K. (PLoS Med. 2010)
    9. Implication of genetic variants near NEGR1, SEC16B, TMEM18, ETV5/DGKG, GNPDA2, LIN7C/BDNF, MTCH2, BCDIN3D/FAIM2, SH2B1, FTO, MC4R, and KCTD15 with obesity and type 2 diabetes in 7705 Chinese. (PubMed id 20215397)1, 4 Ng M.C....Ma R.C. (J. Clin. Endocrinol. Metab. 2010)
    10. Analyses of shared genetic factors between asthma and obesity in children. (PubMed id 20816195)1, 4 MelAcn E....Lasky-Su J. (J. Allergy Clin. Immunol. 2010)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 2119 HGNC: 3494 AceView: ETV5 Ensembl:ENSG00000244405 euGenes: HUgn2119
    ECgene: ETV5 Kegg: 2119 H-InvDB: ETV5

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for ETV5 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for ETV5 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for ETV5 gene:
    Search GeneIP for patents involving ETV5

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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