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Aliases for ETV5 Gene

Aliases for ETV5 Gene

  • Ets Variant 5 2 3
  • ERM 3 4 6
  • Ets-Related Protein ERM 3 4
  • Ets-Related Molecule 2 3
  • Ets Variant Gene 5 (Ets-Related Molecule) 2
  • ETS Translocation Variant 5 3

External Ids for ETV5 Gene

Summaries for ETV5 Gene

GeneCards Summary for ETV5 Gene

ETV5 (Ets Variant 5) is a Protein Coding gene. Diseases associated with ETV5 include neurofibromatosis, type 2. Among its related pathways are Transcriptional misregulation in cancer and Androgen receptor signaling pathway. GO annotations related to this gene include sequence-specific DNA binding transcription factor activity and transcription regulatory region DNA binding. An important paralog of this gene is ETV2.

UniProtKB/Swiss-Prot for ETV5 Gene

  • Binds to DNA sequences containing the consensus nucleotide core sequence GGAA

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ETV5 Gene

Genomics for ETV5 Gene

Genomic Location for ETV5 Gene

Start:
186,046,308 bp from pter
End:
186,110,318 bp from pter
Size:
64,011 bases
Orientation:
Minus strand

Genomic View for ETV5 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ETV5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ETV5 Gene

Regulatory Elements for ETV5 Gene

Transcription factor binding sites by QIAGEN in the ETV5 gene promoter:

Proteins for ETV5 Gene

  • Protein details for ETV5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P41161-ETV5_HUMAN
    Recommended name:
    ETS translocation variant 5
    Protein Accession:
    P41161
    Secondary Accessions:
    • A6NH46
    • B7Z7D7
    • Q6IBN5

    Protein attributes for ETV5 Gene

    Size:
    510 amino acids
    Molecular mass:
    57838 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for ETV5 Gene

    Alternative splice isoforms for ETV5 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ETV5 Gene

Proteomics data for ETV5 Gene at MOPED

Post-translational modifications for ETV5 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ETV5 Gene

No data available for DME Specific Peptides for ETV5 Gene

Domains for ETV5 Gene

Protein Domains for ETV5 Gene

UniProtKB/Swiss-Prot:

ETV5_HUMAN
Domain:
  • Contains 1 ETS DNA-binding domain.:
    • P41161
Family:
  • Belongs to the ETS family.:
    • P41161
genes like me logo Genes that share domains with ETV5: view

No data available for Gene Families for ETV5 Gene

Function for ETV5 Gene

Molecular function for ETV5 Gene

GENATLAS Biochemistry: ETS variant 5,transcription factor of the ETS family,divergent member of the winged helix-turn-helix superfamily,expressed in brain,placenta and other tissues involved in development
UniProtKB/Swiss-Prot Function: Binds to DNA sequences containing the consensus nucleotide core sequence GGAA

Gene Ontology (GO) - Molecular Function for ETV5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000977 RNA polymerase II regulatory region sequence-specific DNA binding IMP 15857832
GO:0000981 sequence-specific DNA binding RNA polymerase II transcription factor activity IBA --
GO:0001228 RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription IMP 15857832
GO:0003677 DNA binding TAS 8152800
GO:0003700 sequence-specific DNA binding transcription factor activity IDA 19443906
genes like me logo Genes that share ontologies with ETV5: view
genes like me logo Genes that share phenotypes with ETV5: view

Animal Models for ETV5 Gene

MGI Knock Outs for ETV5:

miRNA for ETV5 Gene

miRTarBase miRNAs that target ETV5

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for ETV5 Gene

Localization for ETV5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ETV5 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ETV5 Gene COMPARTMENTS Subcellular localization image for ETV5 gene
Compartment Confidence
nucleus 5
cytosol 3
plasma membrane 3

Gene Ontology (GO) - Cellular Components for ETV5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA 19443906
genes like me logo Genes that share ontologies with ETV5: view

Pathways for ETV5 Gene

genes like me logo Genes that share pathways with ETV5: view

Pathways by source for ETV5 Gene

1 GeneGo (Thomson Reuters Life Sciences Research) pathway for ETV5 Gene
1 KEGG pathway for ETV5 Gene

Gene Ontology (GO) - Biological Process for ETV5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006355 regulation of transcription, DNA-templated --
GO:0006357 regulation of transcription from RNA polymerase II promoter IBA --
GO:0006366 transcription from RNA polymerase II promoter IBA --
GO:0007274 neuromuscular synaptic transmission IEA --
GO:0007626 locomotory behavior IEA --
genes like me logo Genes that share ontologies with ETV5: view

Compounds for ETV5 Gene

(3) Novoseek inferred chemical compound relationships for ETV5 Gene

Compound -log(P) Hits PubMed IDs
hyaluronic acid 29.1 1
phosphoinositide 25.3 2
threonine 13.3 2
genes like me logo Genes that share compounds with ETV5: view

Transcripts for ETV5 Gene

Unigene Clusters for ETV5 Gene

Ets variant 5:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ETV5 Gene

No ASD Table

Relevant External Links for ETV5 Gene

GeneLoc Exon Structure for
ETV5
ECgene alternative splicing isoforms for
ETV5

Expression for ETV5 Gene

mRNA expression in normal human tissues for ETV5 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

SOURCE GeneReport for Unigene cluster for ETV5 Gene Hs.43697

mRNA Expression by UniProt/SwissProt for ETV5 Gene

P41161-ETV5_HUMAN
Tissue specificity: Ubiquitous
genes like me logo Genes that share expressions with ETV5: view

Orthologs for ETV5 Gene

This gene was present in the common ancestor of animals.

Orthologs for ETV5 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ETV5 36
  • 99.41 (n)
  • 99.41 (a)
ETV5 37
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia ETV5 36
  • 93.71 (n)
  • 97.64 (a)
ETV5 37
  • 97 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ETV5 36
  • 93.27 (n)
  • 96.67 (a)
ETV5 37
  • 90 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Etv5 36
  • 90.07 (n)
  • 95.49 (a)
Etv5 16
Etv5 37
  • 95 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia ETV5 37
  • 88 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia ETV5 37
  • 74 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Etv5 36
  • 89.74 (n)
  • 94.71 (a)
chicken
(Gallus gallus)
Aves ETV5 36
  • 78.59 (n)
  • 84.19 (a)
ETV5 37
  • 84 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia ETV5 37
  • 84 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii Dr.11545 36
etv5a 36
  • 65.71 (n)
  • 65.98 (a)
etv5a 37
  • 63 (a)
OneToMany
etv5b 37
  • 60 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta Ets96B 37
  • 23 (a)
OneToMany
Ets96B 38
  • 87 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 37
  • 20 (a)
ManyToMany
Species with no ortholog for ETV5:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ETV5 Gene

ENSEMBL:
Gene Tree for ETV5 (if available)
TreeFam:
Gene Tree for ETV5 (if available)

Paralogs for ETV5 Gene

Paralogs for ETV5 Gene

Selected SIMAP similar genes for ETV5 Gene using alignment to 7 proteins:

genes like me logo Genes that share paralogs with ETV5: view

Variants for ETV5 Gene

Sequence variations from dbSNP and Humsavar for ETV5 Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type MAF
rs3758 -- 186,097,245(+) CCAGA(A/G)GTTTG intron-variant
rs8310 -- 186,047,944(-) CTTTT(A/T)TTTTA utr-variant-3-prime
rs869399 -- 186,108,975(-) CCGCC(A/G)GGGCC utr-variant-5-prime
rs869400 -- 186,108,951(-) GAGAG(A/C)GGCCG utr-variant-5-prime
rs869401 -- 186,108,757(-) GGTTC(C/T)TGGGA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ETV5 Gene

Variant ID Type Subtype PubMed ID
esv2665875 CNV Deletion 23128226
esv2726328 CNV Deletion 23290073

Relevant External Links for ETV5 Gene

HapMap Linkage Disequilibrium report
ETV5
Human Gene Mutation Database (HGMD)
ETV5

Disorders for ETV5 Gene

(1) University of Copenhagen DISEASES for ETV5 Gene

(5) Novoseek inferred disease relationships for ETV5 Gene

Disease -log(P) Hits PubMed IDs
neurofibromatosis type 2 67.8 2
schwannoma 30 1
meningioma 25.3 1
tumors 1.99 2
melanoma 0 1

Relevant External Links for ETV5

Genetic Association Database (GAD)
ETV5
Human Genome Epidemiology (HuGE) Navigator
ETV5
genes like me logo Genes that share disorders with ETV5: view

No data available for UniProtKB/Swiss-Prot for ETV5 Gene

Publications for ETV5 Gene

  1. Molecular cloning and characterization of human ERM, a new member of the Ets family closely related to mouse PEA3 and ER81 transcription factors. (PMID: 8152800) Monte D. … Stehelin D. (Oncogene 1994) 2 3 4 23
  2. Genomic organization of the human ERM (ETV5) gene, a PEA3 group member of ETS transcription factors. (PMID: 8661127) Monte D. … de Launoit Y. (Genomics 1996) 3 4 23
  3. Assignment of the ERM gene (ETV5) coding for the ets-related protein to human chromosome band 3q28 by in situ hybridization. (PMID: 8941378) Protopopova M.V. … Graphodatsky A.S. (Cytogenet. Cell Genet. 1996) 3 23
  4. ITAM-based interaction of ERM proteins with Syk mediates signaling by the leukocyte adhesion receptor PSGL-1. (PMID: 12387735) Urzainqui A. … Sanchez-Madrid F. (Immunity 2002) 3 23
  5. Expression of the Ets transcription factor Erm is regulated through a conventional PKC signaling pathway in the Molt4 lymphoblastic cell line. (PMID: 15620692) T'sas F. … de Launoit Y. (FEBS Lett. 2005) 3 23

Products for ETV5 Gene

Sources for ETV5 Gene

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