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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

ETV5 Gene

protein-coding   GIFtS: 63
GCID: GC03M185764

Ets Variant 5

(Previous name: ets variant gene 5 (ets-related molecule))
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Ets Variant 51 2
ERM2 3 5
Ets-Related Molecule1 2
Ets-Related Protein ERM2 3
Ets Variant Gene 5 (Ets-Related Molecule)1
ETS Translocation Variant 52

External Ids:    HGNC: 34941   Entrez Gene: 21192   Ensembl: ENSG000002444057   OMIM: 6016005   UniProtKB: P411613   

Export aliases for ETV5 gene to outside databases

Previous GC identifers: GC03M182555 GC03M187021 GC03M187166 GC03M187085 GC03M187246 GC03M183174


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for ETV5 Gene: 
ETV5 (ets variant 5) is a protein-coding gene. Diseases associated with ETV5 include endometrioid ovary carcinoma, and neurofibromatosis, and among its related super-pathways are Immune response IL-12-induced IFN-gamma production. GO annotations related to this gene include transcription regulatory region DNA binding and sequence-specific DNA binding transcription factor activity. An important paralog of this gene is ELK4.

UniProtKB/Swiss-Prot: ETV5_HUMAN, P41161
Function: Binds to DNA sequences containing the consensus nucleotide core sequence GGAA




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000003.11  NT_005612.16  NC_018914.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the ETV5 gene promoter:
         AML1a   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidETV5 promoter sequence
   Search SABiosciences Chromatin IP Primers for ETV5

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ETV5


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 3q28   Ensembl cytogenetic band:  3q27.2   HGNC cytogenetic band: 3q28

ETV5 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ETV5 gene location

GeneLoc information about chromosome 3         GeneLoc Exon Structure

GeneLoc location for GC03M185764:  view genomic region     (about GC identifiers)

Start:
185,764,097 bp from pter      End:
185,828,107 bp from pter
Size:
64,011 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: ETV5_HUMAN, P41161 (See protein sequence)
Recommended Name: ETS translocation variant 5  
Size: 510 amino acids; 57838 Da
Subcellular location: Nucleus
Mass spectrometry: Mass=57837.98; Method=MALDI; Range=1-510; Source=PubMed:11840567;
Secondary accessions: A6NH46 Q6IBN5

Explore the universe of human proteins at neXtProt for ETV5: NX_P41161

Explore proteomics data for ETV5 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_P41161

  • ETV5 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    ETV5 Protein Expression
    REFSEQ proteins: NP_004445.1  
    ENSEMBL proteins: 
     ENSP00000306894   ENSP00000413755   ENSP00000399707   ENSP00000389707   ENSP00000412171  
     ENSP00000405157   ENSP00000388737   ENSP00000441737  

    Human Recombinant Protein Products for ETV5: 
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    OriGene Protein Over-expression Lysate for ETV5
    OriGene Custom MassSpec 
    OriGene Custom Protein Services for ETV5
    GenScript Custom Purified and Recombinant Proteins Services for ETV5
    Novus Biologicals ETV5 Protein
    Novus Biologicals ETV5 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for ETV5 

    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA19443906

    ETV5 for ontologies           About GeneDecksing



    ETV5 Antibody Products: 
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    ThermoFisher Antibody for ETV5
    LSBio Antibodies in human, mouse, rat for ETV5 

    Assay Products for ETV5: 
    Browse Kits and Assays available from EMD Millipore
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    Cloud-Clone Corp. ELISAs for ETV5 
    Cloud-Clone Corp. CLIAs for ETV5


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    3 InterPro protein domains:
     IPR000418 Ets_dom
     IPR011991 WHTH_DNA-bd_dom
     IPR006715 ETS_PEA3_N

    Graphical View of Domain Structure for InterPro Entry P41161

    ProtoNet protein and cluster: P41161

    1 Blocks protein domain: IPB006715 PEA3-type ETS-domain transcription factor

    UniProtKB/Swiss-Prot: ETV5_HUMAN, P41161
    Similarity: Belongs to the ETS family
    Similarity: Contains 1 ETS DNA-binding domain


    ETV5 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ETV5_HUMAN, P41161
    Function: Binds to DNA sequences containing the consensus nucleotide core sequence GGAA

         Genatlas biochemistry entry for ETV5:
    ETS variant 5,transcription factor of the ETS family,divergent member of the winged helix-turn-helix
    superfamily,expressed in brain,placenta and other tissues involved in development

         Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003677DNA binding TAS8152800
    GO:0003700sequence-specific DNA binding transcription factor activity IDA19443906
    GO:0043565sequence-specific DNA binding IEA--
    GO:0044212transcription regulatory region DNA binding IDA19443906
         
    ETV5 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for ETV5:
     Elongated cells 

         13 MGI mutant phenotypes (inferred from 4 alleles(MGI details for Etv5):
     behavior/neurological  cellular  craniofacial  embryogenesis  endocrine/exocrine gland 
     growth/size  limbs/digits/tail  mortality/aging  nervous system  renal/urinary system 
     reproductive system  respiratory system  skeleton 

    ETV5 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-outs for ETV5: Etv5tm1Kmm Etv5tm1.2Xsun

       inGenious Targeting Laboratory - Custom generated mouse model solutions for ETV5 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for ETV5

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for ETV5 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for ETV5 

    miRNA
    Products:
        
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat ETV5
    8/55 QIAGEN miScript miRNA Assays for microRNAs that regulate ETV5 (see all 55):
    hsa-miR-136 hsa-miR-429 hsa-let-7a-2* hsa-miR-219-5p hsa-miR-764 hsa-miR-1183 hsa-miR-200b hsa-miR-497*
    SwitchGear 3'UTR luciferase reporter plasmidETV5 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for ETV5
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ETV5

    Gene Editing
    Products:
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    Sirion Biotech Customized adenovirus for overexpression of ETV5

    Clone
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    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
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    GenScript: all cDNA clones in your preferred vector: ETV5 (NM_004454)
    Browse Sino Biological Human cDNA Clones
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ETV5
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                         Customized lentivirus expression plasmids for stable overexpression of ETV5 

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    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ETV5


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for ETV5 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Immune response IL-12-induced IFN-gamma production
    Immune response IL-12-induced IFN-gamma production0.88
    2Transcriptional misregulation in cancer
    Transcriptional misregulation in cancer
    3IL12 signaling mediated by STAT4
    IL12 signaling mediated by STAT4
    4Androgen receptor signaling pathway
    Androgen receptor signaling pathway
    5FOXM1 transcription factor network
    FOXM1 transcription factor network

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 EMD Millipore Pathway for ETV5
        Immune response IL-12-induced IFN-gamma production


    1 GeneGo (Thomson Reuters) Pathway for ETV5
        Immune response IL-12-induced IFN-gamma production

    3 BioSystems Pathways for ETV5
        Androgen receptor signaling pathway
    FOXM1 transcription factor network
    IL12 signaling mediated by STAT4


    1         Kegg Pathway  (Kegg details for ETV5):
        Transcriptional misregulation in cancer


    ETV5 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for ETV5

    STRING Interaction Network Preview (showing 5 interactants - click image to see 16)

    5/16 Interacting proteins for ETV5 (P411613 ENSP000003068944) via UniProtKB, MINT, STRING, and/or I2D (see all 16)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ARP102753, ENSP000003638224I2D: score=2 STRING: ENSP00000363822
    RFWD2Q8NHY23, ENSP000003566414I2D: score=1 STRING: ENSP00000356641
    UBCP0CG483, ENSP000003448184I2D: score=1 STRING: ENSP00000344818
    FOXM1ENSP000003423074STRING: ENSP00000342307
    STAT4ENSP000003512554STRING: ENSP00000351255
    About this table

    Gene Ontology (GO): 5/11 biological process terms (GO ID links to tree view) (see all 11):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006355regulation of transcription, DNA-dependent ----
    GO:0007274neuromuscular synaptic transmission IEA--
    GO:0007610behavior IEA--
    GO:0034599cellular response to oxidative stress IDA19443906
    GO:0045666positive regulation of neuron differentiation IEA--

    ETV5 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    ETV5 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for ETV5

    3 Novoseek inferred chemical compound relationships for ETV5 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    hyaluronic acid 29.1 1 15326184 (1)
    phosphoinositide 25.3 2 15096511 (2)
    threonine 13.3 2 17075902 (1), 15652352 (1)

    Search CenterWatch for drugs/clinical trials and news about ETV5

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for ETV5 gene: 
    NM_004454.2  

    Unigene Cluster for ETV5:

    Ets variant 5
    Hs.43697  [show with all ESTs]
    Unigene Representative Sequence: NM_004454
    15 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000306376(uc003fpy.3 uc003fpz.3) ENST00000434744 ENST00000480706
    ENST00000433149 ENST00000489830 ENST00000484223 ENST00000472868 ENST00000440773
    ENST00000421809 ENST00000413301 ENST00000422039 ENST00000476890 ENST00000475484
    ENST00000495808 ENST00000537818
    miRNA
    Products:
         
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat ETV5
    8/55 QIAGEN miScript miRNA Assays for microRNAs that regulate ETV5 (see all 55):
    hsa-miR-136 hsa-miR-429 hsa-let-7a-2* hsa-miR-219-5p hsa-miR-764 hsa-miR-1183 hsa-miR-200b hsa-miR-497*
    SwitchGear 3'UTR luciferase reporter plasmidETV5 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for ETV5
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ETV5
    Clone
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    OriGene ORF clones in mouse, rat for ETV5
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: ETV5 (NM_004454)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for ETV5
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ETV5
    Sirion Biotech Customized lentivirus for stable overexpression of ETV5 
                         Customized lentivirus expression plasmids for stable overexpression of ETV5 
    Primer
    Products:
        
    OriGene qSTAR qPCR primer pairs in human, mouse for ETV5
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ETV5
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ETV5

    Additional mRNA sequence: 

    AK301878.1 BC007333.2 BT006713.1 CR456767.1 X76184.1 

    11 DOTS entries:

    DT.454608  DT.99947371  DT.75178777  DT.120850247  DT.120850280  DT.86841092  DT.91832400  DT.92431695 
    DT.92431699  DT.95173645  DT.318278 

    24/230 AceView cDNA sequences (see all 230):

    BQ425245 BC007333 AI829698 BG482720 BF056238 AI831482 AA219130 AA137020 
    AI206338 AA301189 BQ614503 AA722157 AA369756 BT006713 BM695686 BU625642 
    BP345678 F01802 BQ217349 BM998404 BM313678 AA503077 CB105127 Z44642 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    ETV5 expression in normal human tissues (normalized intensities)      ETV5 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CACCTCCCGG
    ETV5 Expression
    About this image


    ETV5 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/13 selected tissues (see all 13) fully expand
     
     Brain (Nervous System)    fully expand to see all 17 entries
             Thalamus
             N2/LSB induced-cells ( Generation of midbrain dopaminergic, forebrain and hypothalamic...
             Olfactory Bulb   
     
     Tendon & Ligament
             Tendon Progenitor Cells Lumbar Syndetome
     
     Somite (Muscoskeletal System)    fully expand to see all 4 entries
             Tendon Progenitor Cells Lumbar Syndetome
     
     Neural Tube (Nervous System)    fully expand to see all 3 entries
             Telencephalon
     
     Testis (Reproductive System)    fully expand to see all 3 entries
             Spermatogonial Stem Cells Seminiferous Tubules

    See ETV5 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for ETV5

    SOURCE GeneReport for Unigene cluster: Hs.43697

    UniProtKB/Swiss-Prot: ETV5_HUMAN, P41161
    Tissue specificity: Ubiquitous

        SABiosciences Custom PCR Arrays for ETV5
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    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ETV5
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ETV5

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for ETV5 gene from 5/11 species (see all 11)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Etv51 , 5 ets variant gene 51, 5 90.07(n)1
    95.49(a)1
      16 (13.30 cM)5
    1041561  NM_023794.21  NP_076283.21 
     223813095 
    chicken
    (Gallus gallus)
    Aves ETV51 ets variant 5 78.66(n)
    84.19(a)
      395749  XM_422651.2  XP_422651.2 
    lizard
    (Anolis carolinensis)
    Reptilia ETV56
    Uncharacterized protein
    85(a)
    1 ↔ 1
    3(34199906-34249601)
    zebrafish
    (Danio rerio)
    Actinopterygii Dr.115452 Danio rerio mRNA similar to ets variant gene 5 (ets-related more 78.02(n)    BC048059.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Ets96B3 transcription factor 87(a)   96A22   --


    ENSEMBL Gene Tree for ETV5 (if available)
    TreeFam Gene Tree for ETV5 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for ETV5 gene
    ELK42  ETV12  ETV32  ERF2  ETV3L2  ETS12  GABPA2  ETS22  
    ELK12  ERG2  FEV2  ETV42  ETV22  FLI12  ELK32  
    7 SIMAP similar genes for ETV5 using alignment to 7 protein entries:     ETV5_HUMAN (see all proteins):
    ETV1    FEV    TLS-ERG    ELK3    ETV2    ETV4
    DDX5-ETV4 fusion

    ETV5 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/1130 SNPs in ETV5 are shown (see all 1130)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 3 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs130632101,2
    C,F,H--185763735(+) ACTCGA/GAAGTC 1 -- ds50018Minor allele frequency- G:0.02EA NS NA 764
    rs1172790831,2
    C,F--185763794(+) TACACT/CTAAAA 1 -- ds50011Minor allele frequency- C:0.01EA 120
    rs1490347201,2
    --185763818(+) GAATTC/GGTGGC 1 -- ds50010--------
    rs1907628861,2
    --185763863(+) CACCAC/TTGGCT 1 -- ds50010--------
    rs1457408791,2
    --185763869(+) TGGCTA/GGGAAG 1 -- ds50010--------
    rs1822673831,2
    --185763885(+) CTCTCG/TACTTT 1 -- ds50010--------
    rs771515791,2
    C--185763893(+) TTTCCA/TCCTCT 1 -- ds50010--------
    rs774482091,2
    C,F--185763975(+) CTACCC/TTCGAT 1 -- ds50011Minor allele frequency- T:0.02EA 120
    rs1435526771,2
    C--185764049(+) GGGGG-/CTTTTG 1 -- ds50010--------
    rs1874377421,2
    --185764223(+) TCAAGC/GCTTTC 1 -- ut310--------

    HapMap Linkage Disequilibrium report for ETV5 (185764097 - 185828107 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for ETV5:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2665875CNV Deletion23128226
    esv2726328CNV Deletion23290073


    Human Gene Mutation Database (HGMD): ETV5
    SABiosciences Cancer Mutation PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 601600    OMIM disorders: --

    20/22 diseases for ETV5 (see all 22):    About MalaCards
    endometrioid ovary carcinoma    neurofibromatosis    renal agenesis    mastitis
    mantle cell lymphoma    meningioma    b-cell chronic lymphocytic leukemia    anorexia nervosa
    azoospermia    endometrial carcinoma    chronic lymphocytic leukemia    obesity
    gastric cancer    colorectal cancer    prostate cancer    thyroiditis
    squamous cell carcinoma    ovarian cancer    prostatitis    leukemia

    1 disease from the University of Copenhagen DISEASES database for ETV5:
    Renal agenesis

    ETV5 for disorders           About GeneDecksing

    5 Novoseek inferred disease relationships for ETV5 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    neurofibromatosis type 2 67.8 2 10567424 (1), 11368764 (1)
    schwannoma 30 1 11368764 (1)
    meningioma 25.3 1 11368764 (1)
    tumors 1.99 2 15699051 (1), 10567424 (1)
    melanoma 0 1 14704146 (1)

    Genetic Association Database (GAD): ETV5
    Human Genome Epidemiology (HuGE) Navigator: ETV5 (16 documents)

    Export disorders for ETV5 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for ETV5 gene, integrated from 9 sources (see all 88):
    (articles sorted by number of sources associating them with ETV5)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Molecular cloning and characterization of human ERM, a new member of the Ets family closely related to mouse PEA3 and ER81 transcription factors. (PubMed id 8152800)1, 2, 3, 9 Monte D.... Stehelin D. (1994)
    2. Genomic organization of the human ERM (ETV5) gene, a PEA3 group member of ETS transcription factors. (PubMed id 8661127)1, 2, 9 Monte D.... de Launoit Y. (1996)
    3. Association analyses of 249,796 individuals reveal 18 new loci associated with body mass index. (PubMed id 20935630)1, 4 Speliotes E.K....Loos R.J. (2010)
    4. Genetic susceptibility to obesity and related traits in childhood and adolescence: influence of loci identified by genome-wide assoc iation studies. (PubMed id 20724581)1, 4 den Hoed M....Loos R.J. (2010)
    5. Evaluating the discriminative power of multi-trait ge netic risk scores for type 2 diabetes in a northern Swedish population. (PubMed id 20571754)1, 4 Fontaine-Bisson B....Franks P.W. (2010)
    6. Are recently identified genetic variants regulating B MI in the general population associated with anorexia nervosa? (PubMed id 19746409)1, 4 Brandys M.K....Adan R.A. (2010)
    7. Cumulative effects and predictive value of common obe sity-susceptibility variants identified by genome-wide association studies. (PubMed id 19812171)1, 4 Li S....Loos R.J. (2010)
    8. Genetic markers of adult obesity risk are associated with greater early infancy weight gain and growth. (PubMed id 20520848)1, 4 Elks C.E....Ong K.K. (2010)
    9. Implication of genetic variants near NEGR1, SEC16B, T MEM18, ETV5/DGKG, GNPDA2, LIN7C/BDNF, MTCH2, BCDIN3D/FAIM2, SH2B1, FTO, MC4R, a nd KCTD15 with obesity and type 2 diabetes in 7705 Chinese. (PubMed id 20215397)1, 4 Ng M.C....Ma R.C. (2010)
    10. Analyses of shared genetic factors between asthma and obesity in children. (PubMed id 20816195)1, 4 MelAcn E....Lasky-Su J. (2010)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 2119 HGNC: 3494 AceView: ETV5 Ensembl:ENSG00000244405 euGenes: HUgn2119
    ECgene: ETV5 Kegg: 2119 H-InvDB: ETV5

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for ETV5 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for ETV5 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for ETV5 gene:
    Search GeneIP for patents involving ETV5

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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