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ETV4 Gene

protein-coding GIFtS: 59

GC17M038960

ets variant 4
(Previous names: ets variant gene 4 (E1A enhancer-binding protein, E1AF) )
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
About This Section

Aliases
E1A-F ^¹, ², ³
E1AF ^¹, ², ³
PEA3 ^²
PEAS3 ^²

Descriptions
Adenovirus E1A enhancer-binding protein ^³
E1A enhancer binding protein ^²
EWS protein/E1A enhancer binding protein chimera ^²
ets variant 4 ^²
ets variant gene 4 (E1A enhancer binding protein, E1AF) ^²
ets variant gene 4 (E1A enhancer-binding protein, E1AF) ^¹, ²
polyomavirus enhancer activator-3 ^²

External Ids
HGNC: 3493¹
Entrez Gene: 2118²
UniProtKB: P43268³
Ensembl: ENSG00000175832⁷

Search outside databases for aliases for ETV4 gene

Previous GC identifers: GC17U990026 GC17M043782 GC17M041615 GC17M042080

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

UniProtKB/Swiss-Prot: ETV4_HUMAN, P43268

Function: Transcriptional activator that binds to the enhancer of the adenovirus E1A gene; the

core-binding sequence is 5'[AC]GGA[AT]GT-3'

Gene Wiki entry for ETV4

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the ETV4 gene

Entrez Gene cytogenetic band: 17q21 Ensembl cytogenetic band: 17q21.31 HGNC cytogenetic band: 17q21

ETV4 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 17 GeneLoc Exon Structure

GeneLoc location for GC17M038960: (about GC identifiers)

Start:	38,960,737 bp from pter
End:	38,979,288 bp from pter
Size:	18,552 bases
Orientation:	minus strand

RefSeq DNA sequence:

NC_000017.9 NT_010783.14

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
About This Section

UniProtKB/Swiss-Prot: ETV4_HUMAN, P43268 (See protein sequence)

Recommended Name: ETS translocation variant 4

Size: 484 amino acids; 53938 Da

Subcellular location: Nucleus

Secondary accessions: A8K314 Q96AW9

Post-translational modifications:

View phosphorylation sites using PhosphoSite²

REFSEQ proteins (2 alternative transcripts):

NP_001073143.1 NP_001977.1

ENSEMBL proteins:

ENSP00000321835 ENSP00000377273

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Browse Purified and Recombinant Proteins at Millipore
	Browse Human Recombinant Proteins at Sigma-Aldrich
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Recombinant Proteins from Abcam (Pea3)
	Human Recombinant Proteins from Abnova (ETV4)

OriGene Purified Recombinant Human Proteins (see all 2): ETV4

2 Gene Ontology (GO) cellular component terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005634	nucleus	NAS	--
GO:0005730	nucleolus	IDA	18029348

About this table

Antibodies for ETV4:

	Browse Antibodies Central at Invitrogen
	Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	Sigma-Aldrich Antibodies for ETV4
	Browse R&D Systems for Antibodies
	Antibodies from Abcam (Pea3), each with their Abpromise^SM
	Monoclonal and Polyclonal Antibodies from Abnova (ETV4)
	Novus Biologicals Antibodies for ETV4

Assays for ETV4:

	Browse Invitrogen for biochemical assays
	Browse Kits and Assays available from Millipore
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

Graphical View of Domain Structure for InterPro Entry P43268

ProtoNet protein and cluster: P43268

1 Blocks protein family: IPB006715 PEA3-type ETS-domain transcription factor

UniProtKB/Swiss-Prot: ETV4_HUMAN, P43268

Similarity: Belongs to the ETS family

Similarity: Contains 1 ETS DNA-binding domain

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (ETV4)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (ETV4)

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2): NM_001079675

Applied Biosystems Silencer® siRNAs for ETV4

Sigma-Aldrich siRNA for ETV4

Sigma-Aldrich shRNA for ETV4

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Invitrogen Clones for ETV4
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clones in CMV expression vector (see all 2): NM_001079675
Myc/DDK tagged cDNA clones in CMV expression vector (see all 2): NM_001079675
untagged cDNA clones in CMV expression vector (see all 2): NM_001079675

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_001079675

UniProtKB/Swiss-Prot: ETV4_HUMAN, P43268

Function: Transcriptional activator that binds to the enhancer of the adenovirus E1A gene; the

core-binding sequence is 5'[AC]GGA[AT]GT-3'

Genatlas biochemistry entry for ETV4:

ETS variant gene 4,divergent member of the winged helix-turn-helix superfamily,activating matrix

metalloproteinase genes,associated with invasion and metastasis of tumor cell

6 MGI mutant phenotypes (inferred from 3 alleles) (MGI details for Etv4):

behavior/neurological	endocrine/exocrine gland	nervous system	no phenotypic analysis	reproductive system
tumorigenesis

3 Gene Ontology (GO) molecular function terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0003700	transcription factor activity	IEA	--
GO:0016563	transcription activator activity	NAS	--
GO:0043565	sequence-specific DNA binding	IEA	--

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

Gene Network Central^TM Interacting Genes and Proteins Network for ETV4

5/43 Interacting proteins for ETV4 (ENSP00000321835³) via UniProtKB, MINT, and/or STRING (see all 43 )

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
ERBB2	ENSP00000269571³	STRING (score=.966)
MMP14	ENSP00000308208³	STRING (score=.966)
MMP9	ENSP00000361405³	STRING (score=.955)
MMP13	ENSP00000339672³	STRING (score=.953)
JUND	ENSP00000252818³	STRING (score=.93)

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4 Gene Ontology (GO) biological process terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006355	regulation of transcription, DNA-dependent	NAS	--
GO:0008045	motor axon guidance	IEA	--
GO:0009887	organ morphogenesis	IEA	--
GO:0045941	positive regulation of transcription	IEA	--

About this table

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences

Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for ETV4
10 Novoseek chemical compound relationships for ETV4 gene

Compound	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
dc-chol	58.11	2	12845342 (1)
12-o-tetradecanoylphorbol 13-acetate	46.70	3	8463255 (2), 8294454 (1)
matrigel	23.41	3	16912160 (1)
phorbol	22.12	1	10411143 (1)
oleic acid	18.32	9	17168666 (4), 16406575 (2), 16632435 (1)
tyrosine	14.11	6	19014879 (2), 9380403 (1), 8808707 (1)
thymidine	4.82	1	16096014 (1)
nitric oxide	0.00	2	15695237 (1), 15785755 (1)
progesterone	0.00	1	8597501 (1)
cyclic amp	0.00	1	9378725 (1)

About this table

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (ETV4)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (ETV4)

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2): NM_001079675

Sigma-Aldrich siRNA for ETV4

Sigma-Aldrich shRNA for ETV4

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_001079675 NM_001986

REFSEQ mRNAs for ETV4 gene (2 alternative transcripts):

NM_001079675.1 NM_001986.2

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_001079675 NM_001986

               OriGene GFP tagged cDNA clones in CMV expression vector (see all 2): NM_001079675
                                 Myc/DDK tagged cDNA clones in CMV expression vector (see all 2): NM_001079675
                                 untagged cDNA clones in CMV expression vector (see all 2): NM_001079675

Additional cDNA sequence:

AK290429.1 AK298872.1 AK299019.1 AK312934.1 AK315961.1 BC016623.1 D12765.1 DQ396625.1

DQ396626.1 EU693078.1 EU693079.1 U18018.1

14 DOTS entries:

DT.92427459 DT.215718 DT.97845325 DT.86852041 DT.100750074 DT.100750075 DT.100750073 DT.95270495

DT.120927690 DT.92427471 DT.100742349 DT.120927835 DT.92028466 DT.95270493

24/154 AceView cDNA sequences (see all 154 ):

BM980627 D12765 BU554006 BQ954778 R07222 CA417574 BM795147 AA314536

BM555272 BC016623 BX332185 BM825256 AI469414 AW007654 BQ961355 BC007242

BE349131 NM_001986 AA639480 AI346513 BQ000979 BM452151 AI973148 BQ684464

highest scoring ESTs for ETV4:

BC016623 BE621418 BF983153 BM795254 BM818524 BM856372 D12765 U18018 AA010400 AA010506

Unigene Cluster for ETV4:

Ets variant 4

Hs.434059 [show with all ESTs]

Unigene Representative Sequence: NM_001079675

GeneLoc Exon Structure

5/12 Alternative Splicing Database (ASD) splice patterns (SP) for ETV4 (see all 12 )

ExUns:	1a	·	1b	^	2a	·	2b	^	3	^	4a	·	4b	·	4c	·	4d	^	5	^	6	^	7a	·	7b	^	8a	·	8b	^	9a	·	9b	·	9c	^	10a	·	10b	·	10c	^	11a	·	11b	^	12	^	13	^	14	^
SP1:					-		-				-		-		-						-				-																		-
SP2:											-		-		-						-				-
SP3:					-		-		-		-		-		-						-				-
SP4:									-		-		-		-						-				-
SP5:																					-				-						-

ExUns:	15a	·	15b
SP1:
SP2:
SP3:
SP4:
SP5:

About this scheme

ECgene alternative splicing isoforms for ETV4

2 Ensembl transcripts including schematic representations:

ENST00000319349 ENST00000393664

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

ETV4 expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for ETV4

¹ / ² / ³

4 probe-sets matching ETV4 gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
2084_s_at²^{, 3}	U95-A	1	1.00	1.00	1.00	1.00	D12765	0.80	1.00	0.91	1
211603_s_at²	U133-A	1	1.00	1.00	--	--	--	--	--	--	--
211603_s_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
1554576_a_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--

About this table

Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: CAGAAGGTGG

SOURCE GeneReport for Unigene cluster: Hs.434059
Expression variation in blood from EXPOLDB for ETV4

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for ETV4 gene from 5/7 species (see all 7 )

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	ETV4¹	--	ets variant 4	92.62(n) 94.62(a)	403641 XM_537626.2 XP_537626.2
chimpanzee (Pan troglodytes)	ETV4¹	--	ets variant 4	99.59(n) 99.38(a)	454715 XM_511536.2 XP_511536.2
cow (Bos taurus)	ETV4¹	--	similar to ets variant gene 4 (E1A enhancer binding more	93.41(n) 96.18(a)	533129 XM_612436.3 XP_612436.3
rat (Rattus norvegicus)	Etv4¹	--	ets variant 4	90.45(n) 92.89(a)	360635 XM_340910.3 XP_340911.3
mouse (Mus musculus)	Etv4^{1, 5}	11 (60.00 cM)⁵	ets variant gene 4 (E1A enhancer binding protein, E1AF)^{1, 5}	90.34(n)¹ 92.55(a)¹	18612¹ NM_008815.2¹ NP_032841.2¹ AK144538⁵ AK144590⁵ (see all 17)

About this table Species with no ortholog for ETV4

ENSEMBL Gene Tree for ETV4

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

Paralogs for ETV4 gene

ETV1² ETV5²

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

10/84 NCBI SNPs in ETV4 are shown (see all 84 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 43)

AB	SNP ID	Valid	Chr 17 pos	Sequence	Recs	AA Chg	Type	More	Recs	Allele freq	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--				--
--	rs34260468^1,2	C,F	38961559(-)	`ATCAGC/TGTCCA`	2	R/C	mis¹		5		NA EU EA WA	496
	rs1140492^1,2	C	38960828(-)	`CCTTTC/TTTTTG`	2	--	ut3¹		0	--	--	--	--
	rs12948043^1,2	A,C,F,H	38971356(+)	`GTTGGT/CGATCC`	2	--	int¹		4		EU EA WA	418
	rs7222604^1,2	A,C,F,H	38971982(+)	`CCTAGC/GTGTCA`	2	--	int¹		4		EU EA WA	418
	rs4793257^1,2	A,C,F,H	38973702(+)	`GGGGTG/AATGGG`	2	--	int¹		4		EU EA WA	418
	rs2293015^1,2	A,C,F,H	38977525(+)	`CTGGCG/AGCTTC`	2	--	int¹		5		EA EU WA	1908
	rs12603189^1,2	C,F,H	38974203(+)	`TGTTTG/CGTCTT`	2	--	int¹		3		EU EA	300
	rs2242598^1,2	C,F,H	38965924(-)	`ATTCCG/AGAGCC`	2	--	int¹		8		EA NA EU WA	2000
	rs9912927^1,2	F,H	38975561(+)	`GCACTC/GACACT`	2	--	int¹		4		EU EA WA	418
--	rs12603164^1,2	A,C	38974092(+)	`TCTCCC/GAAAGG`	2	--	int¹		0	--	--	--	--

About this table

HapMap Linkage Disequilibrium images for ETV4 (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

OMIM: 600711

10/19 Novoseek disease relationships for ETV4 gene (see all 19 )

Disease	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
breast cancer	47.00	47	16652376 (5), 11821815 (4), 16752078 (4), 14633660 (3) (see all 17)
metastasis	46.00	15	18425363 (2), 17060941 (2), 9467955 (1), 14604892 (1) (see all 13)
tumors	42.10	68	12684413 (4), 14633660 (4), 9380403 (3), 18511876 (3) (see all 32)
ovarian cancer	37.41	4	16652376 (1), 15387369 (1), 17475671 (1)
cancer	32.21	17	9509127 (3), 17168666 (2), 16406575 (2), 15695237 (2) (see all 11)
breast carcinoma	30.37	4	15387369 (3), 14990565 (1)
mammary tumor	30.30	3	15629152 (1), 11467448 (1)
colon cancer	22.13	1	15695237 (1)
adenoma	21.93	5	15800927 (2), 15695237 (2)
carcinoma	21.37	14	12684413 (4), 15800927 (3), 12851697 (1), 18720079 (1) (see all 8)

About this table

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
About This Section

10/176 PubMed articles for ETV4 gene (see all 176 ):

Isolation of a cDNA encoding the adenovirus E1A enhancer binding protein: a new human member of the ets oncogene family. (PubMed id 8441666)^{1, 3, 4} Higashino F.... Fujinaga K. (1993)
Genomic organization of the human e1af gene, a member of Ets transcription factors. (PubMed id 10564827)^{1, 3, 4} Coutte L.... de Launoit Y. (1999)
Assignment of the ets-related transcription factor E1A-F gene (ETV4) to human chromosome region 17q21. (PubMed id 8530053)^{1, 2, 3} Isobe M....Fujinaga K. (1995)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{3, 4} Gerhard D.S....Malek J. (2004)
22 genes from chromosome 17q21: cloning, sequencing, and characterization of mutations in breast cancer families and tumors. (PubMed id 7774926)^{3, 4} Friedman L.S....King M.-C. (1995)
Expression of PEA3 and lack of correlation between PEA3 and HER-2/neu expression in breast cancer. (PubMed id 16752078)^{1, 3} Xia W.Y....Hung M.C. (2006)
PEA3 cooperates with c-Jun in regulation of HER2/neu transcription. (PubMed id 16786139)^{1, 3} Matsui K....Kitajima I. (2006)
PEA3 is the second Ets family transcription factor involved in tumor progression in ovarian carcinoma. (PubMed id 12684413)^{1, 3} Davidson B....Reich R. (2003)
PEA3 is necessary for optimal epidermal growth factor receptor-stimulated matrix metalloproteinase expression and invasion of ovarian tumor cells. (PubMed id 17475671)^{1, 3} Cowden Dahl K.D....Hudson L.G. (2007)
Antitumor activity of an Ets protein, PEA3, in breast cancer cell lines MDA-MB-361DYT2 and BT474M1. (PubMed id 16652376)^{1, 3} Yu Z....Hung M.C. (2006)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
About This Section

Entrez Gene: 2118	HGNC: 3493	AceView: ETV4	Ensembl:ENSG00000175832	euGenes: HUgn2118
ECgene: ETV4	H-InvDB: ETV4

(According to HUGE)
About This Section

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
ATLAS Chromosomes in Cancer entry for ETV4	Genetics and Cytogenetics in Oncology and Haematology

Licensable Technologies for ETV4
(Available from WIS Yeda, Salk, Tufts)

About This Section

(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section

Products for ETV4:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for ETV4-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for ETV4		Antibodies for ETV4
	Explore super-pooled esiRNAs		Browse proteins at Sigma-Aldrich
	Lentivirus-delivered shRNAs for ETV4		Browse small molecules at Sigma-Aldrich
	"Your Favorite Gene" Pathways		feedback

	Antibodies		Primer Pairs
	Cell Culture Products		ELISAs
	Flow Cytometry Kits		Protease Activity Assays & Reagents
	Cell Selection/Detection Kits & Reagents		ELISA/Assay Development Kits & Reagents
	Multiplex/Array Assay Kits & Reagents		ELISpot Kits & Development Modules
	Recombinant & Natural Proteins

	Recombinant Proteins (ETV4)
	Antibodies (ETV4)
	Chimera RNAi (ETV4)
	Custom Service for Mouse Mab
	Custom Service for Rabbit Pab from Full-length Protein

Search for Antibodies & Assays

	Recombinant Proteins (Pea3)
	Antibodies (Pea3)

	Tagged/untagged cDNA clones
	Validated SYBR primer pairs
	Purified proteins from HEK293T cells
	Western blot validated antibodies
	shRNA in GFP-retroviral vector

Search Tocris compounds for ETV4

Search www.enzolifesicences.com for proteins, assays, substrates, inhibitors & antibodies

Antibodies for ETV4

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ETV4 Gene

protein-coding GIFtS: 59

Aliases &
Descriptions
for ETV4

Summaries
for ETV4

Genomic Location
for ETV4

Proteins
for ETV4

Protein Domains/
Families
for ETV4

Gene Function
for ETV4

Pathways & Interactions
for ETV4

Drugs & Compounds
for ETV4

Transcripts
for ETV4

Expression
for ETV4

Orthologs
for ETV4

Paralogs
for ETV4

SNPs/Variants
for ETV4

Disorders & Mutations
for ETV4

Medical News
for ETV4

Publications
for ETV4

Search for ETV4

Genome Databases showing ETV4

Other Databases showing ETV4

Specialized Databases showing ETV4

Licensable Technologies
for ETV4

Services
for ETV4

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

ETV4 Gene

protein-coding GIFtS: 59

Aliases & Descriptionsfor ETV4

Summariesfor ETV4

Genomic Locationfor ETV4

Proteinsfor ETV4

Protein Domains/Familiesfor ETV4

Gene Functionfor ETV4

Pathways & Interactionsfor ETV4

Drugs & Compoundsfor ETV4

Transcriptsfor ETV4

Expression for ETV4

Orthologsfor ETV4

Paralogsfor ETV4

SNPs/Variantsfor ETV4

Disorders & Mutationsfor ETV4

Medical Newsfor ETV4

Publicationsfor ETV4

Search for ETV4

Genome Databases showing ETV4

Other Databases showing ETV4

Specialized Databases showing ETV4

Licensable Technologiesfor ETV4

Servicesfor ETV4

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for ETV4

Summaries
for ETV4

Genomic Location
for ETV4

Proteins
for ETV4

Protein Domains/
Families
for ETV4

Gene Function
for ETV4

Pathways & Interactions
for ETV4

Drugs & Compounds
for ETV4

Transcripts
for ETV4

Expression
for ETV4

Orthologs
for ETV4

Paralogs
for ETV4

SNPs/Variants
for ETV4

Disorders & Mutations
for ETV4

Medical News
for ETV4

Publications
for ETV4

Licensable Technologies
for ETV4

Services
for ETV4