Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 
or upload a file of gene symbols


Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

ETV4 Gene

protein-coding   GIFtS: 59
GCID: GC17M041605

Ets Variant 4

(Previous names: ets variant gene 4 (E1A enhancer-binding protein, E1AF))
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Ets Variant 41 2     PEA32 3
Ets Variant Gene 4 (E1A Enhancer-Binding Protein, E1AF)1 2     E1A Enhancer Binding Protein1
Adenovirus E1A Enhancer-Binding Protein2 3     PEAS32
Polyomavirus Enhancer Activator 3 Homolog2 3     ETS Translocation Variant 42
E1A-F2 3     EWS Protein/E1A Enhancer Binding Protein Chimera2
E1AF2 3     Protein PEA33

External Ids:    HGNC: 34931   Entrez Gene: 21182   Ensembl: ENSG000001758327   OMIM: 6007115   UniProtKB: P432683   

Export aliases for ETV4 gene to outside databases

Previous GC identifers: GC17U990026 GC17M043782 GC17M041615 GC17M042080 GC17M038960 GC17M037370


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for ETV4 Gene: 
ETV4 (ets variant 4) is a protein-coding gene. Diseases associated with ETV4 include extraosseous ewing's sarcoma, and peripheral primitive neuroectodermal tumor, and among its related super-pathways are ErbB Family Pathway and Integrated Cancer pathway. GO annotations related to this gene include sequence-specific DNA binding and sequence-specific DNA binding transcription factor activity. An important paralog of this gene is ELK4.

UniProtKB/Swiss-Prot: ETV4_HUMAN, P43268
Function: Transcriptional activator that binds to the enhancer of the adenovirus E1A gene; the core-binding
sequence is 5'[AC]GGA[AT]GT-3'

Gene Wiki entry for ETV4 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000017.10  NT_010783.15  NC_018928.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the ETV4 gene promoter:
         Sp1   NF-kappaB   NF-kappaB1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidETV4 promoter sequence
   Search SABiosciences Chromatin IP Primers for ETV4

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ETV4


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 17q21   Ensembl cytogenetic band:  17q21.31   HGNC cytogenetic band: 17q21

ETV4 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ETV4 gene location

GeneLoc information about chromosome 17         GeneLoc Exon Structure

GeneLoc location for GC17M041605:  view genomic region     (about GC identifiers)

Start:
41,605,211 bp from pter      End:
41,656,988 bp from pter
Size:
51,778 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: ETV4_HUMAN, P43268 (See protein sequence)
Recommended Name: ETS translocation variant 4  
Size: 484 amino acids; 53938 Da
Subcellular location: Nucleus
Sequence caution: Sequence=AAA95991.1; Type=Erroneous initiation;
Secondary accessions: A8K314 B7Z5J3 B7Z9J6 Q96AW9
Alternative splicing: 2 isoforms:  P43268-1   P43268-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for ETV4: NX_P43268

Explore proteomics data for ETV4 at MOPED 

Post-translational modifications:

  • UniProtKB: Sumoylated; enhanced upon ERK/MAP kinase pathway activation, it positively regulates the transcriptional activator
    capacity. Sumoylation at Lys-96 probably requires phosphorylation at Ser-101. Transiently polysumoylated and
    desumoylated by SENP1. Sumoylation is a prerequisite to polyubiquitination which in turn increases
    proteasomal-mediated degradation. Probably polyubiquitinated by RNF4 and deubiquitinated by USP2
  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_P43268

  • ETV4 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    ETV4 Protein Expression
    REFSEQ proteins (5 alternative transcripts): 
    NP_001073143.1  NP_001248366.1  NP_001248367.1  NP_001248368.1  NP_001977.1  

    ENSEMBL proteins: 
     ENSP00000321835   ENSP00000377273   ENSP00000440023   ENSP00000441749   ENSP00000465718  
     ENSP00000468636   ENSP00000466673   ENSP00000443846  

    Human Recombinant Protein Products for ETV4: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    OriGene Protein Over-expression Lysate for ETV4
    OriGene Custom MassSpec 
    OriGene Custom Protein Services for ETV4
    GenScript Custom Purified and Recombinant Proteins Services for ETV4
    Novus Biologicals ETV4 Protein
    Novus Biologicals ETV4 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for ETV4 

    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005622intracellular ----
    GO:0005634nucleus NAS--
    GO:0005730nucleolus IDA--

    ETV4 for ontologies           About GeneDecksing



    ETV4 Antibody Products: 
    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for ETV4
    GenScript Custom Superior Antibodies Services for ETV4
    Novus Biologicals ETV4 Antibodies
    Abcam antibodies for ETV4
    Cloud-Clone Corp. Antibodies for ETV4 
    ThermoFisher Antibody for ETV4
    LSBio Antibodies in human, mouse, rat for ETV4 

    Assay Products for ETV4: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for ETV4
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for ETV4
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for ETV4 
    Cloud-Clone Corp. CLIAs for ETV4


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    3 InterPro protein domains:
     IPR000418 Ets_dom
     IPR011991 WHTH_DNA-bd_dom
     IPR006715 ETS_PEA3_N

    Graphical View of Domain Structure for InterPro Entry P43268

    ProtoNet protein and cluster: P43268

    1 Blocks protein domain: IPB006715 PEA3-type ETS-domain transcription factor

    UniProtKB/Swiss-Prot: ETV4_HUMAN, P43268
    Similarity: Belongs to the ETS family
    Similarity: Contains 1 ETS DNA-binding domain


    ETV4 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ETV4_HUMAN, P43268
    Function: Transcriptional activator that binds to the enhancer of the adenovirus E1A gene; the core-binding
    sequence is 5'[AC]GGA[AT]GT-3'

         Genatlas biochemistry entry for ETV4:
    ETS variant gene 4,divergent member of the winged helix-turn-helix superfamily,activating matrix metalloproteinase
    genes,associated with invasion and metastasis of tumor cell

         Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003677DNA binding ----
    GO:0003700sequence-specific DNA binding transcription factor activity IEA--
    GO:0043565sequence-specific DNA binding IEA--
         
    ETV4 for ontologies           About GeneDecksing


    Phenotypes:
         13 MGI mutant phenotypes (inferred from 3 alleles(MGI details for Etv4):
     behavior/neurological  embryogenesis  endocrine/exocrine gland  integument  limbs/digits/tail 
     mortality/aging  muscle  nervous system  no phenotypic analysis  renal/urinary system 
     reproductive system  skeleton  tumorigenesis 

    ETV4 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Etv4tm1Hass for ETV4

       inGenious Targeting Laboratory - Custom generated mouse model solutions for ETV4 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for ETV4

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for ETV4 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for ETV4 

    miRNA
    Products:
        
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat ETV4
    8/11 QIAGEN miScript miRNA Assays for microRNAs that regulate ETV4 (see all 11):
    hsa-miR-3065-3p hsa-miR-589* hsa-miR-29c hsa-miR-29a hsa-miR-3918 hsa-miR-646 hsa-miR-661 hsa-miR-361-3p
    SwitchGear 3'UTR luciferase reporter plasmidETV4 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for ETV4
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ETV4

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for ETV4
    Sirion Biotech Customized adenovirus for overexpression of ETV4

    Clone
    Products:
         
    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene clones in human, mouse for ETV4 (see all 13)
    OriGene ORF clones in mouse, rat for ETV4
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): ETV4 (NM_001986)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for ETV4
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ETV4
    Sirion Biotech Customized lentivirus for stable overexpression of ETV4 
                         Customized lentivirus expression plasmids for stable overexpression of ETV4 

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for ETV4
    Search LifeMap BioReagents cell lines for ETV4
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ETV4


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for ETV4 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1ErbB4 Pathway
    ErbB2-ErbB3 Heterodimers0.49
    2Prostate Cancer
    Prostate Cancer0.32
    3Transcriptional misregulation in cancer
    Transcriptional misregulation in cancer
    4LKB1 signaling events
    LKB1 signaling events

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 Downloadable PowerPoint Slide of QIAGEN Pathway Central Maps for ETV4
        ErbB2-ErbB3 Heterodimers

    2 BioSystems Pathways for ETV4
        Prostate Cancer
    LKB1 signaling events


    1         Kegg Pathway  (Kegg details for ETV4):
        Transcriptional misregulation in cancer


    ETV4 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for ETV4

    STRING Interaction Network Preview (showing 5 interactants - click image to see 12)

    5/12 Interacting proteins for ETV4 (P432683 ENSP000003218354) via UniProtKB, MINT, STRING, and/or I2D (see all 12)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    HOXD4P090163, ENSP000003025484I2D: score=1 STRING: ENSP00000302548
    RFWD2Q8NHY23, ENSP000003566414I2D: score=1 STRING: ENSP00000356641
    SRFP118313, ENSP000002653544I2D: score=1 STRING: ENSP00000265354
    UBA2Q9UBT23, ENSP000002465484I2D: score=1 STRING: ENSP00000246548
    EP300Q094723, ENSP000002632534I2D: score=1 STRING: ENSP00000263253
    About this table

    Gene Ontology (GO): 5/8 biological process terms (GO ID links to tree view) (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006351transcription, DNA-dependent IEA--
    GO:0006355regulation of transcription, DNA-dependent NAS--
    GO:0008045motor neuron axon guidance IEA--
    GO:0033600negative regulation of mammary gland epithelial cell proliferation IEA--
    GO:0045893positive regulation of transcription, DNA-dependent NAS--

    ETV4 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    ETV4 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for ETV4

    10/16 Novoseek inferred chemical compound relationships for ETV4 gene (see all 16)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    dc-chol 57.1 2 12845342 (1)
    12-o-tetradecanoylphorbol 13-acetate 46.1 3 8463255 (2), 8294454 (1)
    chloramphenicol 26.4 2 8294454 (1), 15756447 (1)
    matrigel 21.5 3 16912160 (1)
    phorbol 21.5 1 10411143 (1)
    oleic acid 16.8 9 17168666 (4), 16406575 (2), 16632435 (1)
    tyrosine 12.8 6 19014879 (2), 9380403 (1), 8808707 (1)
    cyclic amp 4.65 1 9378725 (1)
    thymidine 4.06 1 16096014 (1)
    serine 0.259 4 15350549 (1), 19014879 (1), 8808707 (1)

    Search CenterWatch for drugs/clinical trials and news about ETV4

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for ETV4 gene (5 alternative transcripts): 
    NM_001079675.2  NM_001261437.1  NM_001261438.1  NM_001261439.1  NM_001986.2  

    Unigene Cluster for ETV4:

    Ets variant 4
    Hs.434059  [show with all ESTs]
    Unigene Representative Sequence: NM_001079675
    11 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000319349(uc002idx.3 uc010wij.2) ENST00000393664(uc002idv.3 uc010wih.2 uc002idw.3 uc010czh.3 uc010wii.2)
    ENST00000545954(uc002idy.1) ENST00000545089 ENST00000591713 ENST00000586826
    ENST00000590236 ENST00000585508 ENST00000587151 ENST00000586764 ENST00000538265

    miRNA
    Products:
         
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat ETV4
    8/11 QIAGEN miScript miRNA Assays for microRNAs that regulate ETV4 (see all 11):
    hsa-miR-3065-3p hsa-miR-589* hsa-miR-29c hsa-miR-29a hsa-miR-3918 hsa-miR-646 hsa-miR-661 hsa-miR-361-3p
    SwitchGear 3'UTR luciferase reporter plasmidETV4 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for ETV4
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ETV4
    Clone
    Products:
         
    OriGene clones in human, mouse for ETV4 (see all 13)
    OriGene ORF clones in mouse, rat for ETV4
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): ETV4 (NM_001986)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for ETV4
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ETV4
    Sirion Biotech Customized lentivirus for stable overexpression of ETV4 
                         Customized lentivirus expression plasmids for stable overexpression of ETV4 
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for ETV4
    OriGene qSTAR qPCR primer pairs in human, mouse for ETV4
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat ETV4
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ETV4
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ETV4

    Additional mRNA sequence: 

    AK290429.1 AK298872.1 AK299019.1 AK312934.1 AK315961.1 BC007242.1 BC016623.1 D12765.1 
    DQ396625.1 DQ396626.1 EU693078.1 EU693079.1 U18018.1 

    14 DOTS entries:

    DT.92427459  DT.215718  DT.97845325  DT.86852041  DT.100750074  DT.100750075  DT.100750073  DT.95270495 
    DT.120927690  DT.92427471  DT.100742349  DT.120927835  DT.92028466  DT.95270493 

    24/154 AceView cDNA sequences (see all 154):

    NM_001986 BM825256 BM555272 BM795147 BE349131 BQ961355 AA627986 BM980627 
    AI973148 AW007654 BC016623 BU554006 BQ684464 R07222 BQ954778 BM452151 
    D12765 BQ000979 AA314536 CA417574 AI346513 AA639480 BX332185 BC007242 

    GeneLoc Exon Structure

    5/12 Alternative Splicing Database (ASD) splice patterns (SP) for ETV4 (see all 12)    About this scheme

    ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4a · 4b · 4c · 4d ^ 5 ^ 6 ^ 7a · 7b ^ 8a · 8b ^ 9a · 9b · 9c ^ 10a · 10b · 10c ^ 11a · 11b ^ 12 ^ 13 ^ 14 ^
    SP1:              -     -           -     -     -                 -           -                                                     -                           
    SP2:                                -     -     -                 -           -                                                                                 
    SP3:              -     -     -     -     -     -                 -           -                                                                                 
    SP4:                          -     -     -     -                 -           -                                                                                 
    SP5:                                                              -           -                 -                                                               

    ExUns: 15a · 15b
    SP1:            
    SP2:            
    SP3:            
    SP4:            
    SP5:            


    ECgene alternative splicing isoforms for ETV4

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    ETV4 expression in normal human tissues (normalized intensities)      ETV4 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CAGAAGGTGG
    ETV4 Expression
    About this image


    ETV4 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/31 selected tissues (see all 31) fully expand
     
     Kidney (Urinary System)    fully expand to see all 8 entries
             Ureteric Bud Tip Cells Ureteric Bud
             Proximal Tubule
             kidney ; cells in tubules   
     
     Spinal Cord (Nervous System)    fully expand to see all 7 entries
             Anterior Latissimus Dorsi Muscle Motor Neurons Caudal Brachial Lateral Motor Division
     
     Somite (Muscoskeletal System)    fully expand to see all 4 entries
             Tendon Progenitor Cells Thoracic Syndetome
     
     Tendon & Ligament
             Tendon Progenitor Cells Thoracic Syndetome
     
     Neural Ectoderm (Nervous System)    fully expand to see all 3 entries
             Spinal Neural Plate Cells Neural Plate
             Neural Plate

    See ETV4 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for ETV4

    SOURCE GeneReport for Unigene cluster: Hs.434059
        SABiosciences Expression via Pathway-Focused PCR Array including ETV4: 
              Tumor Metastasis in human mouse rat

    Primer
    Products:
    OriGene qPCR primer pairs and template standards for ETV4
    OriGene qSTAR qPCR primer pairs in human, mouse for ETV4
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat ETV4
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ETV4
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ETV4
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ETV4

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for ETV4 gene from 5/11 species (see all 11)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Etv41 , 5 ets variant gene 4 (E1A enhancer binding protein, E1AF)1, 5 90.34(n)1
    92.55(a)1
      11 (65.48 cM)5
    186121  NM_008815.21  NP_032841.21 
     1017697475 
    chicken
    (Gallus gallus)
    Aves ETV46
    ets variant 4
    63(a)
    1 ↔ 1
    27(3335561-3350183)
    lizard
    (Anolis carolinensis)
    Reptilia ETV46
    ets variant 4
    68(a)
    1 ↔ 1
    6(77931456-77966922)
    zebrafish
    (Danio rerio)
    Actinopterygii AF168008.12   -- 81.43(n)   30700  AF168008.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Ets96B6
    Ets96B
    22(a)
    1 → many
    3R(20617465-20623678)


    ENSEMBL Gene Tree for ETV4 (if available)
    TreeFam Gene Tree for ETV4 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for ETV4 gene
    ELK42  ETV12  ETV32  ERF2  ETV52  ETV3L2  ETS12  GABPA2  
    ETS22  ELK12  ERG2  FEV2  ETV22  FLI12  ELK32  
    7 SIMAP similar genes for ETV4 using alignment to 4 protein entries:     ETV4_HUMAN (see all proteins):
    DDX5-ETV4 fusion    ETV2    ELK3    ETV1    ETV5    FEV
    TLS-ERG

    ETV4 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/438 SNPs in ETV4 are shown (see all 438)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 17 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1845558021,2
    --41604775(+) ATGCAA/GTTGGG 5 -- int10--------
    rs739875201,2
    C,F--41604860(+) GTCCCA/GGGAGG 5 -- int14Minor allele frequency- G:0.14WA CSA 122
    rs739875211,2
    C,F--41604954(+) GGGGCG/ACCTGT 5 -- int12Minor allele frequency- A:0.50WA CSA 4
    rs1461955311,2
    --41605016(+) TGCTGG/TGAAGG 5 -- int10--------
    rs1886883141,2
    --41605048(+) GCCCAC/TTTTTC 5 -- int10--------
    rs1378822911,2
    --41605070(+) AGTCAG/TGTGAA 5 -- int10--------
    rs1928827381,2
    --41605080(+) ACTGCC/GTTTTT 5 -- int10--------
    rs1858678561,2
    --41605110(+) TAAGCA/GCCAGG 5 -- int10--------
    rs1893790481,2
    --41605126(+) GCCCCA/GAACCA 5 -- int10--------
    rs1494850801,2
    C--41605198(+) AAGAGA/GACACA 5 -- int10--------

    HapMap Linkage Disequilibrium report for ETV4 (41605211 - 41656988 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for ETV4:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv2059CNV Insertion18451855
    nsv470588CNV Gain18288195
    nsv833453CNV Gain+Loss17160897

    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing ETV4
    DNA2.0 Custom Variant and Variant Library Synthesis for ETV4

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 600711    OMIM disorders: --

    20/31 diseases for ETV4 (see all 31):    About MalaCards
    extraosseous ewing's sarcoma    peripheral primitive neuroectodermal tumor    stomach cancer    malignant peripheral nerve sheath tumor
    primitive neuroectodermal tumor    seminoma    oral cancer    oral squamous cell carcinoma
    esophageal squamous cell carcinoma    pancreatic cancer    squamous cell carcinoma    colon cancer
    gastric cancer    colorectal cancer    osteosarcoma    sarcoma
    cervical cancer    adenoma    ovarian cancer    esophagitis

    3 diseases from the University of Copenhagen DISEASES database for ETV4:
    Peripheral primitive neuroectodermal tumor     Prostate cancer     Breast cancer

    ETV4 for disorders           About GeneDecksing

    10/19 Novoseek inferred disease relationships for ETV4 gene (see all 19)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    breast cancer 47.1 48 16652376 (5), 11821815 (4), 16752078 (4), 14633660 (3) (see all 18)
    metastasis 44.5 15 18425363 (2), 17060941 (2), 9467955 (1), 14604892 (1) (see all 13)
    tumors 42 77 12684413 (4), 14633660 (4), 9380403 (3), 19845529 (3) (see all 35)
    ovarian cancer 35.7 4 16652376 (1), 15387369 (1), 17475671 (1)
    mammary tumor 35.7 4 20107508 (1), 15629152 (1), 11467448 (1)
    cancer 31.1 17 9509127 (3), 17168666 (2), 16406575 (2), 15695237 (2) (see all 11)
    breast carcinoma 29.2 4 15387369 (3), 14990565 (1)
    adenoma 20.6 5 15800927 (2), 15695237 (2)
    colon cancer 20.3 1 15695237 (1)
    carcinoma 20.1 14 12684413 (4), 15800927 (3), 12851697 (1), 18720079 (1) (see all 8)


    Export disorders for ETV4 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for ETV4 gene, integrated from 9 sources (see all 201):
    (articles sorted by number of sources associating them with ETV4)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Isolation of a cDNA encoding the adenovirus E1A enhancer binding protein: a new human member of the ets oncogene family. (PubMed id 8441666)1, 2, 9 Higashino F.... Fujinaga K. (1993)
    2. Genomic organization of the human e1af gene, a member of Ets transcription factors. (PubMed id 10564827)1, 2, 9 Coutte L.... de Launoit Y. (1999)
    3. Assignment of the ets-related transcription factor E1A-F gene (ETV4) to human chromosome region 17q21. (PubMed id 8530053)1, 3, 9 Isobe M....Fujinaga K. (1995)
    4. Extracellular signal-regulated kinase mitogen-activat ed protein kinase signaling initiates a dynamic interplay between sumoylation a nd ubiquitination to regulate the activity of the transcriptional activator PEA 3. (PubMed id 19307308)1, 2 Guo B. and Sharrocks A.D. (2009)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    6. 22 genes from chromosome 17q21: cloning, sequencing, and characterization of mutations in breast cancer families and tumors. (PubMed id 7774926)1, 2 Friedman L.S....King M.-C. (1995)
    7. Expression of PEA3 and lack of correlation between PEA3 and HER-2/neu expression in breast cancer. (PubMed id 16752078)1, 9 Xia W.Y....Hung M.C. (2006)
    8. PEA3 cooperates with c-Jun in regulation of HER2/neu transcription. (PubMed id 16786139)1, 9 Matsui K....Kitajima I. (2006)
    9. PEA3 is the second Ets family transcription factor involved in tumor progression in ovarian carcinoma. (PubMed id 12684413)1, 9 Davidson B....Reich R. (2003)
    10. PEA3 is necessary for optimal epidermal growth factor receptor-stimulated matrix metalloproteinase expression and invasion of ovarian tumor cells. (PubMed id 17475671)1, 9 Cowden Dahl K.D....Hudson L.G. (2007)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 2118 HGNC: 3493 AceView: ETV4 Ensembl:ENSG00000175832 euGenes: HUgn2118
    ECgene: ETV4 Kegg: 2118 H-InvDB: ETV4

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for ETV4 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for ETV4 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for ETV4 gene:
    Search GeneIP for patents involving ETV4

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

     
     EMD Millipore Custom Antibody & Bulk Services
     EMD Millipore Preclinical / Clinical Development Services
     EMD Millipore Immunoassay Services
     EMD Millipore Target Screening & Profiling Services

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
     Browse ELISpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Multiplex/Array Assay Kits/Reagents  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Protease Activity Assays and Reagents   Browse Recombinant/Natural Proteins  
     Browse Stem Cell Products   Browse Tocris Biochemicals & Compounds  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     Browse OriGene Antibodies   OriGene RNAi products in human, mouse, rat for ETV4  
     OriGene qPCR primer pairs and template standards for ETV4   OriGene Protein Over-expression Lysate for ETV4  
     OriGene Custom Mass Spec   OriGene clones in human, mouse for ETV4  
     OriGene qSTAR qPCR primer pairs in human, mouse for ETV4   Browse OriGene full length recombinant human proteins expressed in human HEK293 cells  
     OriGene ORF clones in mouse, rat for ETV4   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for ETV4   OriGene Custom Protein Services for ETV4  

     
     
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat ETV4
     QIAGEN SeqTarget long-range PCR primers for resequencing ETV4
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ETV4
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ETV4
     QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ETV4
     QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ETV4
     GenScript Custom Purified and Recombinant Proteins Services for ETV4 GenScript cDNA clones with any tag delivered in your preferred vector for ETV4
     GenScript Custom Assay Services for ETV4 GenScript Custom Superior Antibodies Services for ETV4
     GenScript Custom overexpressing Cell Line Services for ETV4 CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Search for Antibodies & Assays

     Regulatory tfbs in ETV4 promoter
     Search Chromatin IP Primers for ETV4
     RT2 qPCR Primer Assay in human, mouse, rat ETV4
     GNC Network for ETV4
     SABiosciences PCR Arrays including human, mouse, rat ETV4
     Search Tocris compounds for ETV4
     Browse Sino Biological Proteins and Antibodies
     Browse Sino Biological Cell Lysates
     Browse Sino Biological cDNA Clones
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     ETV4 antibodies
     ETV4 proteins
     ETV4 lysates
     Antibodies for ETV4
     See all of Abcam's Antibodies, Kits and Proteins for ETV4
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins




     Proteins for ETV4
     Antibodies for ETV4
     ELISAs for ETV4
     CLIAs for ETV4
     Search LifeMap BioReagents cell lines for ETV4
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ETV4
     SwitchGear 3'UTR luciferase reporter plasmids for ETV4
     SwitchGear Promoter luciferase reporter plasmids for ETV4
     ThermoFisher Antibody for ETV4
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ETV4
     inGenious Targeting Laboratory - Custom generated mouse model solutions for ETV4
     inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for ETV4
    Customized:
     lentivirus for stable overexpression of ETV4
     lentivirus expression plasmids for stable overexpression of ETV4
     adenovirus for overexpression of ETV4
     LSBio Antibodies in human, mouse, rat for ETV4
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
           
    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

    View Random Gene

    Category
    (GIFtS: 73)
    transforming growth factor, beta 1
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      ETV4 gene at Home site.
    hostname: 356980-web2.xennexinc.com index build: 106 solr: 1.4