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Aliases for ETV3L Gene

Aliases for ETV3L Gene

  • Ets Variant 3-Like 2 3
  • Ets Variant Gene 3-Like 2

External Ids for ETV3L Gene

Previous GeneCards Identifiers for ETV3L Gene

  • GC01M155330
  • GC01M128420

Summaries for ETV3L Gene

GeneCards Summary for ETV3L Gene

ETV3L (Ets Variant 3-Like) is a Protein Coding gene. GO annotations related to this gene include sequence-specific DNA binding transcription factor activity and sequence-specific DNA binding. An important paralog of this gene is ETV2.

UniProtKB/Swiss-Prot for ETV3L Gene

  • Transcriptional regulator.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ETV3L Gene

Genomics for ETV3L Gene

Regulatory Elements for ETV3L Gene

Genomic Location for ETV3L Gene

Start:
157,092,043 bp from pter
End:
157,099,808 bp from pter
Size:
7,766 bases
Orientation:
Minus strand

Genomic View for ETV3L Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ETV3L Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ETV3L Gene

Proteins for ETV3L Gene

  • Protein details for ETV3L Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6ZN32-ETV3L_HUMAN
    Recommended name:
    ETS translocation variant 3-like protein
    Protein Accession:
    Q6ZN32
    Secondary Accessions:

    Protein attributes for ETV3L Gene

    Size:
    361 amino acids
    Molecular mass:
    39948 Da
    Quaternary structure:
    No Data Available

neXtProt entry for ETV3L Gene

Proteomics data for ETV3L Gene at MOPED

Post-translational modifications for ETV3L Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ETV3L Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for ETV3L Gene

Domains for ETV3L Gene

Protein Domains for ETV3L Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for ETV3L Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q6ZN32

UniProtKB/Swiss-Prot:

ETV3L_HUMAN :
  • Q6ZN32
Domain:
  • Contains 1 ETS DNA-binding domain.
Family:
  • Belongs to the ETS family.
genes like me logo Genes that share domains with ETV3L: view

No data available for Gene Families for ETV3L Gene

Function for ETV3L Gene

Molecular function for ETV3L Gene

UniProtKB/Swiss-Prot Function: Transcriptional regulator.

Gene Ontology (GO) - Molecular Function for ETV3L Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000981 sequence-specific DNA binding RNA polymerase II transcription factor activity IBA --
GO:0003700 sequence-specific DNA binding transcription factor activity --
GO:0043565 sequence-specific DNA binding IEA --
genes like me logo Genes that share ontologies with ETV3L: view

Animal Model Products

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ETV3L

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for ETV3L Gene

Localization for ETV3L Gene

Subcellular locations from UniProtKB/Swiss-Prot for ETV3L Gene

Gene Ontology (GO) - Cellular Components for ETV3L Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IBA --
genes like me logo Genes that share ontologies with ETV3L: view

No data available for Subcellular locations from COMPARTMENTS for ETV3L Gene

Pathways for ETV3L Gene

SuperPathways for ETV3L Gene

No Data Available

Interacting Proteins for ETV3L Gene

Gene Ontology (GO) - Biological Process for ETV3L Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006355 regulation of transcription, DNA-templated --
GO:0006357 regulation of transcription from RNA polymerase II promoter IBA --
GO:0006366 transcription from RNA polymerase II promoter IBA --
GO:0030154 cell differentiation IBA --
genes like me logo Genes that share ontologies with ETV3L: view

No data available for Pathways by source for ETV3L Gene

Transcripts for ETV3L Gene

mRNA/cDNA for ETV3L Gene

(1) REFSEQ mRNAs :
(5) Selected AceView cDNA sequences:
(1) Additional mRNA sequences :
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for ETV3L Gene

Ets variant 3-like:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ETV3L

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for ETV3L
  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ETV3L Gene

No ASD Table

Relevant External Links for ETV3L Gene

GeneLoc Exon Structure for
ETV3L
ECgene alternative splicing isoforms for
ETV3L

Expression for ETV3L Gene

mRNA expression in normal human tissues for ETV3L Gene

mRNA differential expression in normal tissues according to GTEx for ETV3L Gene

This gene is overexpressed in Brain - Nucleus accumbens (basal ganglia) (7.9).

SOURCE GeneReport for Unigene cluster for ETV3L Gene Hs.127138

genes like me logo Genes that share expressions with ETV3L: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein expression and mRNA Expression by UniProt/SwissProt for ETV3L Gene

Orthologs for ETV3L Gene

This gene was present in the common ancestor of chordates.

Orthologs for ETV3L Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ETV3L 35
  • 99.26 (n)
  • 98.06 (a)
ETV3L 36
  • 98 (a)
OneToOne
cow
(Bos Taurus)
Mammalia ETV3L 35
  • 83.19 (n)
  • 76.9 (a)
ETV3L 36
  • 76 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ETV3L 35
  • 81.88 (n)
  • 76.06 (a)
ETV3L 36
  • 76 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Etv3l 35
  • 75.73 (n)
  • 65.72 (a)
Etv3l 16
rat
(Rattus norvegicus)
Mammalia Etv3l 35
  • 83.25 (n)
  • 79.37 (a)
chicken
(Gallus gallus)
Aves ETV3L 36
  • 64 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia ETV3L 36
  • 87 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii erfl3 36
  • 23 (a)
ManyToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 35 (a)
OneToMany
Species with no ortholog for ETV3L:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ETV3L Gene

ENSEMBL:
Gene Tree for ETV3L (if available)
TreeFam:
Gene Tree for ETV3L (if available)

Paralogs for ETV3L Gene

Paralogs for ETV3L Gene

Selected SIMAP similar genes for ETV3L Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with ETV3L: view

Variants for ETV3L Gene

Sequence variations from dbSNP and Humsavar for ETV3L Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs983226 -- 157,100,645(+) gtctc(A/G)aactc upstream-variant-2KB
rs983227 -- 157,100,999(+) aCCAT(A/G)GACAG upstream-variant-2KB
rs1055106 -- 157,092,181(-) ACCCT(A/G)GAAAC utr-variant-3-prime
rs1055107 -- 157,092,169(-) CCTGT(C/T)CCATG utr-variant-3-prime
rs1176535 -- 157,091,758(+) GGGCC(A/G)TTCTT downstream-variant-500B

Relevant External Links for ETV3L Gene

HapMap Linkage Disequilibrium report
ETV3L

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for ETV3L Gene

Disorders for ETV3L Gene

Relevant External Links for ETV3L

Genetic Association Database (GAD)
ETV3L
genes like me logo Genes that share disorders with ETV3L: view

No data available for UniProtKB/Swiss-Prot for ETV3L Gene

Publications for ETV3L Gene

  1. Conduct disorder and ADHD: evaluation of conduct problems as a categorical and quantitative trait in the international multicentre ADHD genetics study. (PMID: 18951430) Anney R.J. … Gill M. (Am. J. Med. Genet. B Neuropsychiatr. Genet. 2008) 3 48
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 4

Products for ETV3L Gene

Sources for ETV3L Gene

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