Free for academic non-profit institutions. Other users need a Commercial license

Aliases for ETV3L Gene

Aliases for ETV3L Gene

  • ETS Variant 3 Like 2 3
  • Ets Variant Gene 3-Like 2
  • Ets Variant 3-Like 5

External Ids for ETV3L Gene

Previous GeneCards Identifiers for ETV3L Gene

  • GC01M155330
  • GC01M128420

Summaries for ETV3L Gene

GeneCards Summary for ETV3L Gene

ETV3L (ETS Variant 3 Like) is a Protein Coding gene. GO annotations related to this gene include transcription factor activity, sequence-specific DNA binding and RNA polymerase II transcription factor activity, sequence-specific DNA binding. An important paralog of this gene is ETS2.

UniProtKB/Swiss-Prot for ETV3L Gene

  • Transcriptional regulator.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ETV3L Gene

Genomics for ETV3L Gene

Regulatory Elements for ETV3L Gene

Genomic Location for ETV3L Gene

Chromosome:
1
Start:
157,092,043 bp from pter
End:
157,099,808 bp from pter
Size:
7,766 bases
Orientation:
Minus strand

Genomic View for ETV3L Gene

Genes around ETV3L on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ETV3L Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ETV3L Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ETV3L Gene

Proteins for ETV3L Gene

  • Protein details for ETV3L Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6ZN32-ETV3L_HUMAN
    Recommended name:
    ETS translocation variant 3-like protein
    Protein Accession:
    Q6ZN32

    Protein attributes for ETV3L Gene

    Size:
    361 amino acids
    Molecular mass:
    39948 Da
    Quaternary structure:
    No Data Available

neXtProt entry for ETV3L Gene

Proteomics data for ETV3L Gene at MOPED

Post-translational modifications for ETV3L Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ETV3L Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for ETV3L Gene

Domains & Families for ETV3L Gene

Gene Families for ETV3L Gene

Protein Domains for ETV3L Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for ETV3L Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q6ZN32

UniProtKB/Swiss-Prot:

ETV3L_HUMAN :
  • Contains 1 ETS DNA-binding domain.
  • Belongs to the ETS family.
Domain:
  • Contains 1 ETS DNA-binding domain.
Family:
  • Belongs to the ETS family.
genes like me logo Genes that share domains with ETV3L: view

Function for ETV3L Gene

Molecular function for ETV3L Gene

UniProtKB/Swiss-Prot Function:
Transcriptional regulator.

Gene Ontology (GO) - Molecular Function for ETV3L Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding IBA --
GO:0001227 transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding IEA --
genes like me logo Genes that share ontologies with ETV3L: view

Phenotypes for ETV3L Gene

genes like me logo Genes that share phenotypes with ETV3L: view

Animal Model Products

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for ETV3L Gene

Localization for ETV3L Gene

Subcellular locations from UniProtKB/Swiss-Prot for ETV3L Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ETV3L Gene COMPARTMENTS Subcellular localization image for ETV3L gene
Compartment Confidence
nucleus 3

No data available for Gene Ontology (GO) - Cellular Components for ETV3L Gene

Pathways & Interactions for ETV3L Gene

SuperPathways for ETV3L Gene

No Data Available

Interacting Proteins for ETV3L Gene

Gene Ontology (GO) - Biological Process for ETV3L Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0030154 cell differentiation IBA --
genes like me logo Genes that share ontologies with ETV3L: view

No data available for Pathways by source and SIGNOR curated interactions for ETV3L Gene

Drugs & Compounds for ETV3L Gene

No Compound Related Data Available

Transcripts for ETV3L Gene

mRNA/cDNA for ETV3L Gene

(1) REFSEQ mRNAs :
(1) Additional mRNA sequences :
(5) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for ETV3L Gene

Ets variant 3-like:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ETV3L Gene

No ASD Table

Relevant External Links for ETV3L Gene

GeneLoc Exon Structure for
ETV3L
ECgene alternative splicing isoforms for
ETV3L

Expression for ETV3L Gene

mRNA expression in normal human tissues for ETV3L Gene

mRNA differential expression in normal tissues according to GTEx for ETV3L Gene

This gene is overexpressed in Brain - Nucleus accumbens (basal ganglia) (x7.9).

SOURCE GeneReport for Unigene cluster for ETV3L Gene Hs.127138

genes like me logo Genes that share expression patterns with ETV3L: view

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for ETV3L Gene

Orthologs for ETV3L Gene

This gene was present in the common ancestor of chordates.

Orthologs for ETV3L Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ETV3L 36
  • 98 (a)
OneToOne
ETV3L 35
  • 99.26 (n)
  • 98.06 (a)
cow
(Bos Taurus)
Mammalia ETV3L 35
  • 83.19 (n)
  • 76.9 (a)
ETV3L 36
  • 76 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ETV3L 36
  • 76 (a)
OneToOne
ETV3L 35
  • 81.88 (n)
  • 76.06 (a)
mouse
(Mus musculus)
Mammalia Etv3l 16
Etv3l 35
  • 75.73 (n)
  • 65.72 (a)
rat
(Rattus norvegicus)
Mammalia Etv3l 35
  • 83.25 (n)
  • 79.37 (a)
chicken
(Gallus gallus)
Aves ETV3L 36
  • 64 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia ETV3L 36
  • 87 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii erfl3 36
  • 23 (a)
ManyToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 35 (a)
OneToMany
Species with no ortholog for ETV3L:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ETV3L Gene

ENSEMBL:
Gene Tree for ETV3L (if available)
TreeFam:
Gene Tree for ETV3L (if available)

Paralogs for ETV3L Gene

Paralogs for ETV3L Gene

(4) SIMAP similar genes for ETV3L Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with ETV3L: view

Variants for ETV3L Gene

Sequence variations from dbSNP and Humsavar for ETV3L Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs16838078 - 157,099,469(+) ACCTG(A/C)GATCC reference, missense
rs12136960 - 157,092,947(+) AAGCC(C/G)CTGGG reference, missense
rs12126791 - 157,092,783(+) CTCCA(C/T)CATGG reference, missense
rs12083811 - 157,098,741(+) TGGCC(A/G)ACACA reference, missense
rs983226 -- 157,100,645(+) gtctc(A/G)aactc upstream-variant-2KB

Variation tolerance for ETV3L Gene

Residual Variation Intolerance Score: 96.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 7.79; 83.36% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ETV3L Gene

HapMap Linkage Disequilibrium report
ETV3L

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for ETV3L Gene

Disorders for ETV3L Gene

Relevant External Links for ETV3L

Genetic Association Database (GAD)
ETV3L
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ETV3L

No disorders were found for ETV3L Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ETV3L Gene

Publications for ETV3L Gene

  1. Conduct disorder and ADHD: evaluation of conduct problems as a categorical and quantitative trait in the international multicentre ADHD genetics study. (PMID: 18951430) Anney R.J. … Gill M. (Am. J. Med. Genet. B Neuropsychiatr. Genet. 2008) 3 48 67

Products for ETV3L Gene

Sources for ETV3L Gene

Back to Top

Content