Free for academic non-profit institutions. Other users need a Commercial license

Aliases for ETV3L Gene

Aliases for ETV3L Gene

  • ETS Variant 3 Like 2 3 5
  • Ets Variant Gene 3-Like 2

External Ids for ETV3L Gene

Previous GeneCards Identifiers for ETV3L Gene

  • GC01M155330
  • GC01M128420

Summaries for ETV3L Gene

GeneCards Summary for ETV3L Gene

ETV3L (ETS Variant 3 Like) is a Protein Coding gene. GO annotations related to this gene include transcription factor activity, sequence-specific DNA binding and RNA polymerase II transcription factor activity, sequence-specific DNA binding. An important paralog of this gene is ETV3.

UniProtKB/Swiss-Prot for ETV3L Gene

  • Transcriptional regulator.

Additional gene information for ETV3L Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ETV3L Gene

Genomics for ETV3L Gene

Regulatory Elements for ETV3L Gene

Enhancers for ETV3L Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH01H157153 1.9 FANTOM5 Ensembl ENCODE dbSUPER 12 -55.3 -55281 3 ATF1 ZFP64 ARID4B ZNF2 ZNF766 GLIS2 GATA2 ZNF143 RUNX3 DEK ETV3 ETV3L RRNAD1 ENSG00000229961
GH01H157131 1.7 FANTOM5 ENCODE dbSUPER 11.3 -35.8 -35753 8 HDGF PKNOX1 FOXA2 ARNT ARID4B SIN3A DMAP1 ZNF766 ZNF143 ZNF207 ETV3 RRNAD1 ETV3L CCT3 PRCC CYCSP52
GH01H157147 1.3 Ensembl ENCODE dbSUPER 10.9 -48.2 -48245 1 ATF1 TBL1XR1 BACH1 PYGO2 ZNF644 FOSL1 ZNF316 EGR1 FOXK2 FOS ETV3L ETV3 ENSG00000229961
GH01H157073 0.9 Ensembl 11.4 +25.5 25466 0 HDAC1 ELF3 ATF1 RB1 ARID4B ZNF2 RAD21 GLIS2 GATA2 ZSCAN5C ARHGEF11 ETV3L KRT8P45
GH01H157142 0.9 FANTOM5 dbSUPER 11.1 -42.6 -42573 0 PKNOX1 EED IKZF1 DPF2 IKZF2 SPI1 ETV3 ETV3L RRNAD1 ENSG00000229961
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around ETV3L on UCSC Golden Path with GeneCards custom track

Genomic Location for ETV3L Gene

Chromosome:
1
Start:
157,092,043 bp from pter
End:
157,099,808 bp from pter
Size:
7,766 bases
Orientation:
Minus strand

Genomic View for ETV3L Gene

Genes around ETV3L on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ETV3L Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ETV3L Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ETV3L Gene

Proteins for ETV3L Gene

  • Protein details for ETV3L Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6ZN32-ETV3L_HUMAN
    Recommended name:
    ETS translocation variant 3-like protein
    Protein Accession:
    Q6ZN32

    Protein attributes for ETV3L Gene

    Size:
    361 amino acids
    Molecular mass:
    39948 Da
    Quaternary structure:
    No Data Available

neXtProt entry for ETV3L Gene

Post-translational modifications for ETV3L Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ETV3L Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for ETV3L Gene

Domains & Families for ETV3L Gene

Gene Families for ETV3L Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Transcription factors

Protein Domains for ETV3L Gene

Suggested Antigen Peptide Sequences for ETV3L Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q6ZN32

UniProtKB/Swiss-Prot:

ETV3L_HUMAN :
  • Belongs to the ETS family.
Family:
  • Belongs to the ETS family.
genes like me logo Genes that share domains with ETV3L: view

Function for ETV3L Gene

Molecular function for ETV3L Gene

UniProtKB/Swiss-Prot Function:
Transcriptional regulator.

Gene Ontology (GO) - Molecular Function for ETV3L Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding IBA --
GO:0001227 transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding IEA --
GO:0003677 DNA binding IEA --
GO:0003700 transcription factor activity, sequence-specific DNA binding IEA --
GO:0043565 sequence-specific DNA binding IEA --
genes like me logo Genes that share ontologies with ETV3L: view
genes like me logo Genes that share phenotypes with ETV3L: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for ETV3L
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for ETV3L Gene

Localization for ETV3L Gene

Subcellular locations from UniProtKB/Swiss-Prot for ETV3L Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ETV3L gene
Compartment Confidence
nucleus 3

Gene Ontology (GO) - Cellular Components for ETV3L Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IBA --
genes like me logo Genes that share ontologies with ETV3L: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for ETV3L Gene

Pathways & Interactions for ETV3L Gene

SuperPathways for ETV3L Gene

No Data Available

Interacting Proteins for ETV3L Gene

Gene Ontology (GO) - Biological Process for ETV3L Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription from RNA polymerase II promoter IEA --
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0006357 regulation of transcription from RNA polymerase II promoter IBA --
GO:0030154 cell differentiation IBA --
genes like me logo Genes that share ontologies with ETV3L: view

No data available for Pathways by source and SIGNOR curated interactions for ETV3L Gene

Drugs & Compounds for ETV3L Gene

No Compound Related Data Available

Transcripts for ETV3L Gene

mRNA/cDNA for ETV3L Gene

(1) REFSEQ mRNAs :
(1) Additional mRNA sequences :
(5) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for ETV3L Gene

Ets variant 3-like:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for ETV3L
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for ETV3L Gene

No ASD Table

Relevant External Links for ETV3L Gene

GeneLoc Exon Structure for
ETV3L
ECgene alternative splicing isoforms for
ETV3L

Expression for ETV3L Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ETV3L Gene

mRNA differential expression in normal tissues according to GTEx for ETV3L Gene

This gene is overexpressed in Brain - Nucleus accumbens (basal ganglia) (x7.9).

NURSA nuclear receptor signaling pathways regulating expression of ETV3L Gene:

ETV3L

SOURCE GeneReport for Unigene cluster for ETV3L Gene:

Hs.127138

Evidence on tissue expression from TISSUES for ETV3L Gene

  • Nervous system(4)
genes like me logo Genes that share expression patterns with ETV3L: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ETV3L Gene

Orthologs for ETV3L Gene

This gene was present in the common ancestor of chordates.

Orthologs for ETV3L Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ETV3L 33 34
  • 99.26 (n)
rat
(Rattus norvegicus)
Mammalia Etv3l 33
  • 83.25 (n)
cow
(Bos Taurus)
Mammalia ETV3L 33 34
  • 83.19 (n)
dog
(Canis familiaris)
Mammalia ETV3L 33 34
  • 81.88 (n)
mouse
(Mus musculus)
Mammalia Etv3l 33 16
  • 75.73 (n)
chicken
(Gallus gallus)
Aves ETV3L 34
  • 64 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia ETV3L 34
  • 87 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii erfl3 34
  • 23 (a)
ManyToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 35 (a)
OneToMany
Species where no ortholog for ETV3L was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ETV3L Gene

ENSEMBL:
Gene Tree for ETV3L (if available)
TreeFam:
Gene Tree for ETV3L (if available)

Paralogs for ETV3L Gene

Paralogs for ETV3L Gene

(4) SIMAP similar genes for ETV3L Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with ETV3L: view

Variants for ETV3L Gene

Sequence variations from dbSNP and Humsavar for ETV3L Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs1000074639 -- 157,097,259(+) CCTGA(G/T)GTCAG intron-variant
rs1000108424 -- 157,097,686(+) CTTGA(A/G)CCTTT intron-variant
rs1000461633 -- 157,091,983(+) CAGAA(C/T)GCAGG downstream-variant-500B
rs1000757230 -- 157,093,968(+) TTTAA(C/T)GTCTG intron-variant
rs1000923900 -- 157,101,103(+) ACAAA(A/C)TATCT upstream-variant-2KB

Variation tolerance for ETV3L Gene

Residual Variation Intolerance Score: 96.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 7.79; 83.36% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ETV3L Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ETV3L

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for ETV3L Gene

Disorders for ETV3L Gene

Relevant External Links for ETV3L

Genetic Association Database (GAD)
ETV3L
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ETV3L

No disorders were found for ETV3L Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ETV3L Gene

Publications for ETV3L Gene

  1. Conduct disorder and ADHD: evaluation of conduct problems as a categorical and quantitative trait in the international multicentre ADHD genetics study. (PMID: 18951430) Anney RJ … Gill M (American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics 2008) 3 45 60
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 4 60

Products for ETV3L Gene

Sources for ETV3L Gene

Content
Loading form....