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Aliases for ETV3 Gene

Aliases for ETV3 Gene

  • Ets Variant 3 2 3
  • PE1 3 4 6
  • Ets Variant Gene 3, ETS Family Transcriptional Repressor 2 3
  • Mitogenic Ets Transcriptional Suppressor 3 4
  • ETS Domain Transcriptional Repressor PE1 3 4
  • PE-1 3 4
  • METS 3 4
  • ETS Translocation Variant 3 3
  • Ets Variant Gene 3 2
  • BA110J1.4 3

External Ids for ETV3 Gene

Previous GeneCards Identifiers for ETV3 Gene

  • GC01M154963
  • GC01M152859
  • GC01M153872
  • GC01M154311
  • GC01M153907
  • GC01M155357
  • GC01M128452

Summaries for ETV3 Gene

GeneCards Summary for ETV3 Gene

ETV3 (Ets Variant 3) is a Protein Coding gene. Diseases associated with ETV3 include brain cancer. Among its related pathways are Macrophage Differentiation and Growth Inhibition by METS. GO annotations related to this gene include sequence-specific DNA binding transcription factor activity and sequence-specific DNA binding. An important paralog of this gene is ETV2.

UniProtKB/Swiss-Prot for ETV3 Gene

  • Transcriptional repressor that contribute to growth arrest during terminal macrophage differentiation by repressing target genes involved in Ras-dependent proliferation. Represses MMP1 promoter activity.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ETV3 Gene

Genomics for ETV3 Gene

Regulatory Elements for ETV3 Gene

Transcription factor binding sites by QIAGEN in the ETV3 gene promoter:

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for ETV3 Gene

Start:
157,121,191 bp from pter
End:
157,138,591 bp from pter
Size:
17,401 bases
Orientation:
Minus strand

Genomic View for ETV3 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ETV3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ETV3 Gene

Proteins for ETV3 Gene

  • Protein details for ETV3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P41162-ETV3_HUMAN
    Recommended name:
    ETS translocation variant 3
    Protein Accession:
    P41162
    Secondary Accessions:
    • B4E3M7
    • Q8TAC8
    • Q9BX30

    Protein attributes for ETV3 Gene

    Size:
    512 amino acids
    Molecular mass:
    57001 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAA60949.1; Type=Frameshift; Positions=174; Evidence={ECO:0000305};

    Alternative splice isoforms for ETV3 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ETV3 Gene

Proteomics data for ETV3 Gene at MOPED

Post-translational modifications for ETV3 Gene

  • Ubiquitination at Lys114 and Lys224
  • Modification sites at PhosphoSitePlus

Other Protein References for ETV3 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for ETV3 Gene

Domains for ETV3 Gene

Protein Domains for ETV3 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for ETV3 Gene

Graphical View of Domain Structure for InterPro Entry

P41162

UniProtKB/Swiss-Prot:

ETV3_HUMAN :
  • P41162
Domain:
  • Contains 1 ETS DNA-binding domain.
Family:
  • Belongs to the ETS family.
genes like me logo Genes that share domains with ETV3: view

No data available for Gene Families for ETV3 Gene

Function for ETV3 Gene

Molecular function for ETV3 Gene

GENATLAS Biochemistry: ETS variant gene 3,expressed in numerous cell lines,divergent member of the winged helix-turn-helix superfamily
UniProtKB/Swiss-Prot Function: Transcriptional repressor that contribute to growth arrest during terminal macrophage differentiation by repressing target genes involved in Ras-dependent proliferation. Represses MMP1 promoter activity.

Gene Ontology (GO) - Molecular Function for ETV3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000981 sequence-specific DNA binding RNA polymerase II transcription factor activity IBA --
GO:0003674 molecular_function ND --
GO:0003700 sequence-specific DNA binding transcription factor activity --
GO:0005515 protein binding --
GO:0043565 sequence-specific DNA binding IEA --
genes like me logo Genes that share ontologies with ETV3: view

Animal Model Products

CRISPR Products

miRNA for ETV3 Gene

miRTarBase miRNAs that target ETV3

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for ETV3 Gene

Localization for ETV3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ETV3 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ETV3 Gene COMPARTMENTS Subcellular localization image for ETV3 gene
Compartment Confidence
nucleus 5
extracellular 2
lysosome 1

Gene Ontology (GO) - Cellular Components for ETV3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IBA --
GO:0017053 transcriptional repressor complex IEA --
genes like me logo Genes that share ontologies with ETV3: view

Pathways for ETV3 Gene

genes like me logo Genes that share pathways with ETV3: view

Pathways by source for ETV3 Gene

Gene Ontology (GO) - Biological Process for ETV3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription from RNA polymerase II promoter IEA --
GO:0006355 regulation of transcription, DNA-templated --
GO:0006357 regulation of transcription from RNA polymerase II promoter IBA --
GO:0006366 transcription from RNA polymerase II promoter IBA --
GO:0008150 biological_process ND --
genes like me logo Genes that share ontologies with ETV3: view

Transcripts for ETV3 Gene

Unigene Clusters for ETV3 Gene

Ets variant 3:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ETV3

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ETV3 Gene

No ASD Table

Relevant External Links for ETV3 Gene

GeneLoc Exon Structure for
ETV3
ECgene alternative splicing isoforms for
ETV3

Expression for ETV3 Gene

mRNA expression in normal human tissues for ETV3 Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for ETV3 Gene

SOURCE GeneReport for Unigene cluster for ETV3 Gene Hs.105636

genes like me logo Genes that share expressions with ETV3: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for ETV3 Gene

Orthologs for ETV3 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ETV3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ETV3 35
  • 99.67 (n)
  • 99.41 (a)
ETV3 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia ETV3 35
  • 90.77 (n)
  • 92.14 (a)
ETV3 36
  • 92 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ETV3 35
  • 90.96 (n)
  • 93.12 (a)
ETV3 36
  • 88 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Etv3 35
  • 85.95 (n)
  • 86.67 (a)
Etv3 16
Etv3 36
  • 86 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia ETV3 36
  • 85 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia ETV3 36
  • 96 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Etv3 35
  • 86.86 (n)
  • 87.06 (a)
chicken
(Gallus gallus)
Aves ETV3 35
  • 74.11 (n)
  • 77.87 (a)
ETV3 36
  • 74 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia ETV3 36
  • 67 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.32326 35
tropical clawed frog
(Silurana tropicalis)
Amphibia etv3 35
  • 66.74 (n)
  • 68.99 (a)
zebrafish
(Danio rerio)
Actinopterygii erf 36
  • 38 (a)
ManyToMany
si:ch211-265g22.4 36
  • 40 (a)
ManyToMany
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.5256 35
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 36 (a)
OneToMany
Species with no ortholog for ETV3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ETV3 Gene

ENSEMBL:
Gene Tree for ETV3 (if available)
TreeFam:
Gene Tree for ETV3 (if available)

Paralogs for ETV3 Gene

Paralogs for ETV3 Gene

Selected SIMAP similar genes for ETV3 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with ETV3: view

Variants for ETV3 Gene

Sequence variations from dbSNP and Humsavar for ETV3 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs913083 -- 157,123,942(+) AAAAG(A/G)AAAAA utr-variant-3-prime
rs985457 -- 157,138,195(+) CTGGG(C/T)GAGGC intron-variant
rs998842 -- 157,132,661(+) GTGGC(G/T)AGTAC intron-variant
rs1177850 -- 157,121,291(+) AAAAa(A/T)atgta utr-variant-3-prime
rs1467661 -- 157,139,182(+) AAACG(C/G)GTGTC upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for ETV3 Gene

Variant ID Type Subtype PubMed ID
nsv3121 CNV Loss 18451855
esv2718474 CNV Deletion 23290073

Relevant External Links for ETV3 Gene

HapMap Linkage Disequilibrium report
ETV3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ETV3 Gene

Disorders for ETV3 Gene

MalaCards: The human disease database

MalaCards: The human disease database. (1) Diseases for ETV3 Gene including...

Search for ETV3 Gene in MalaCards »

(2) University of Copenhagen DISEASES for ETV3 Gene

Relevant External Links for ETV3

Genetic Association Database (GAD)
ETV3
genes like me logo Genes that share disorders with ETV3: view

No data available for UniProtKB/Swiss-Prot for ETV3 Gene

Publications for ETV3 Gene

  1. PE-1, a novel ETS oncogene family member, localizes to chromosome 1q21-q23. (PMID: 8020980) Klemsz M. … Hoffman R. (Genomics 1994) 2 3 4
  2. An induced Ets repressor complex regulates growth arrest during terminal macrophage differentiation. (PMID: 12007404) Klappacher G.W. … Glass C.K. (Cell 2002) 3 4
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  4. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory S.G. … Bentley D.R. (Nature 2006) 3 4
  5. Conduct disorder and ADHD: evaluation of conduct problems as a categorical and quantitative trait in the international multicentre ADHD genetics study. (PMID: 18951430) Anney R.J. … Gill M. (Am. J. Med. Genet. B Neuropsychiatr. Genet. 2008) 3 48

Products for ETV3 Gene

Sources for ETV3 Gene

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