Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 



ETV3 Gene

protein-coding   GIFtS: 50
GCID: GC01M157090

Ets Variant 3

(Previous names: ets variant gene 3, ETS family transcriptional repressor,...)
  See ETV3-related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

TryGeneCards Plus

Aliases
Ets Variant 31 2     PE-12 3
PE12 3 5     ETS Domain Transcriptional Repressor PE12 3
Ets Variant Gene 3, ETS Family Transcriptional Repressor1 2     Ets Variant Gene 31
Mitogenic Ets Transcriptional Suppressor2 3     bA110J1.42
METS2 3     ETS Translocation Variant 32

External Ids:    HGNC: 34921   Entrez Gene: 21172   Ensembl: ENSG000001170367   OMIM: 1648735   UniProtKB: P411623   

Export aliases for ETV3 gene to outside databases

Previous GC identifers: GC01M154963 GC01M152859 GC01M153872 GC01M154311 GC01M153907 GC01M155357 GC01M128452


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

TryGeneCards Plus

GeneCards Summary for ETV3 Gene:
ETV3 (ets variant 3) is a protein-coding gene. Diseases associated with ETV3 include brain cancer. GO annotations related to this gene include sequence-specific DNA binding and sequence-specific DNA binding transcription factor activity. An important paralog of this gene is ETV1.

UniProtKB/Swiss-Prot: ETV3_HUMAN, P41162
Function: Transcriptional repressor that contribute to growth arrest during terminal macrophage differentiation by
repressing target genes involved in Ras-dependent proliferation. Represses MMP1 promoter activity




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

TryGeneCards Plus
RefSeq DNA sequence at NCBI GenBank:
NC_000001.10  NT_004487.20  NC_018912.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the ETV3 gene promoter:
         AML1a   STAT3   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidETV3 promoter sequence
   Search Chromatin IP Primers for ETV3

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ETV3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1q21-q23   Ensembl cytogenetic band:  1q23.1   HGNC cytogenetic band: 1q21-q23

ETV3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ETV3 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01M157090:  view genomic region     (about GC identifiers)

Start:
157,090,983 bp from pter      End:
157,108,383 bp from pter
Size:
17,401 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
About This Section

TryGeneCards Plus

UniProtKB/Swiss-Prot: ETV3_HUMAN, P41162 (See protein sequence)
Recommended Name: ETS translocation variant 3  
Size: 512 amino acids; 57001 Da
Sequence caution: Sequence=AAA60949.1; Type=Frameshift; Positions=174;
Secondary accessions: B4E3M7 Q8TAC8 Q9BX30
Alternative splicing: 2 isoforms:  P41162-1   P41162-2   

Explore the universe of human proteins at neXtProt for ETV3: NX_P41162

Explore proteomics data for ETV3 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys114, Lys224
  • Modification sites at PhosphoSitePlus

  • See ETV3 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001138784.1  NP_005231.1  

    ENSEMBL proteins: 
     ENSP00000357175   ENSP00000327316  

    ETV3 Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    OriGene Protein Over-expression Lysate for ETV3
    OriGene Custom MassSpec
    OriGene Custom Protein Services for ETV3
    GenScript Custom Purified and Recombinant Proteins Services for ETV3
    Novus Biologicals ETV3 Proteins
    Novus Biologicals ETV3 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for ETV3

     
    Search eBioscience for Proteins for ETV3 

    ETV3 Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for ETV3
    Novus Biologicals ETV3 Antibodies
    Abcam antibodies for ETV3
    Cloud-Clone Corp. Antibodies for ETV3
    Search ThermoFisher Antibodies for ETV3
    LSBio Antibodies in human, mouse, rat for ETV3

    ETV3 Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for ETV3
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for ETV3
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for ETV3
    Cloud-Clone Corp. CLIAs for ETV3
    Search eBioscience for ELISAs for ETV3 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    TryGeneCards Plus
    2 InterPro protein domains:
     IPR000418 Ets_dom
     IPR011991 WHTH_DNA-bd_dom

    Graphical View of Domain Structure for InterPro Entry P41162

    ProtoNet protein and cluster: P41162

    UniProtKB/Swiss-Prot: ETV3_HUMAN, P41162
    Similarity: Belongs to the ETS family
    Similarity: Contains 1 ETS DNA-binding domain


    Find genes that share domains with ETV3           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ETV3_HUMAN, P41162
    Function: Transcriptional repressor that contribute to growth arrest during terminal macrophage differentiation by
    repressing target genes involved in Ras-dependent proliferation. Represses MMP1 promoter activity

         Genatlas biochemistry entry for ETV3:
    ETS variant gene 3,expressed in numerous cell lines,divergent member of the winged helix-turn-helix superfamily

         Gene Ontology (GO): 5 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000981sequence-specific DNA binding RNA polymerase II transcription factor activity IBA--
    GO:0003674molecular_function ND--
    GO:0003700sequence-specific DNA binding transcription factor activity ----
    GO:0005515protein binding ----
    GO:0043565sequence-specific DNA binding IEA--
         
    Find genes that share ontologies with ETV3           About GenesLikeMe


    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for ETV3
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for ETV3

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for ETV3
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for ETV3

    miRNA
    Products:
        
    miRTarBase miRNAs that target ETV3:
    hsa-mir-196a-5p (MIRT048238), hsa-mir-182-5p (MIRT047196)

    Block miRNA regulation of human, mouse, rat ETV3 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate ETV3 (see all 11):
    hsa-miR-2052 hsa-miR-3140-3p hsa-miR-187* hsa-miR-222 hsa-miR-3921 hsa-miR-221 hsa-miR-3161 hsa-miR-145
    SwitchGear 3'UTR luciferase reporter plasmidETV3 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for ETV3
    Predesigned siRNA for gene silencing in human, mouse, rat ETV3

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for ETV3

    Clone
    Products:
         
    OriGene clones in human, mouse for ETV3 (see all 10)
    OriGene ORF clones in mouse, rat for ETV3
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): ETV3 (NM_001145312)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for ETV3
    Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat ETV3

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for ETV3
    Browse ESI BIO Cell Lines and PureStem Progenitors for ETV3 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ETV3


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Subcellular locations from UniProtKB/Swiss-Prot
    ETV3_HUMAN, P41162: Nucleus (Potential)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    extracellular2
    lysosome1

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IBA--
    GO:0017053transcriptional repressor complex IEA--

    Find genes that share ontologies with ETV3           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
    About This Section

    TryGeneCards Plus

    SuperPaths for ETV3 About    
    See pathways by source

    SuperPathContained pathways About
    1Macrophage Differentiation and Growth Inhibition by METS
    Macrophage Differentiation and Growth Inhibition by METS0.30

    1 Downloadable PowerPoint Slide of GeneGlobe Pathway Central Maps for ETV3
        Macrophage Differentiation and Growth Inhibition by METS


        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for ETV3
    Interactions:

        GeneGlobe Interaction Network for ETV3

    STRING Interaction Network Preview (showing 3 interactants - click image to see more details)

    3 Interacting proteins for ETV3 (P411623 ENSP000003571754) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    MYCP011063, ENSP000003672074I2D: score=1 STRING: ENSP00000367207
    DDX20Q9UHI63, ENSP000003587164I2D: score=3 STRING: ENSP00000358716
    MAPK3ENSP000002630254STRING: ENSP00000263025
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000122negative regulation of transcription from RNA polymerase II promoter IEA--
    GO:0006351transcription, DNA-templated ----
    GO:0006355regulation of transcription, DNA-templated ----
    GO:0006357regulation of transcription from RNA polymerase II promoter IBA--
    GO:0006366transcription from RNA polymerase II promoter IBA--

    Find genes that share ontologies with ETV3           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
    About This Section

    TryGeneCards Plus
    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for ETV3



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
    About This Section

    TryGeneCards Plus

    REFSEQ mRNAs for ETV3 gene (2 alternative transcripts): 
    NM_001145312.1  NM_005240.1  

    Unigene Cluster for ETV3:

    Ets variant 3
    Hs.105636  [show with all ESTs]
    Unigene Representative Sequence: AK316274
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000368192(uc001fqr.2) ENST00000326786(uc001fqt.3) ENST00000460850

    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat ETV3 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate ETV3 (see all 11):
    hsa-miR-2052 hsa-miR-3140-3p hsa-miR-187* hsa-miR-222 hsa-miR-3921 hsa-miR-221 hsa-miR-3161 hsa-miR-145
    SwitchGear 3'UTR luciferase reporter plasmidETV3 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for ETV3
    Predesigned siRNA for gene silencing in human, mouse, rat ETV3
    Clone
    Products:
         
    OriGene clones in human, mouse for ETV3 (see all 10)
    OriGene ORF clones in mouse, rat for ETV3
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): ETV3 (NM_001145312)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for ETV3
    Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat ETV3
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for ETV3
    OriGene qSTAR qPCR primer pairs in human, mouse for ETV3
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat ETV3
      QuantiTect SYBR Green Assays in human, mouse, rat ETV3
      QuantiFast Probe-based Assays in human, mouse, rat ETV3

    Additional mRNA sequence: 

    AF218540.1 AK304789.1 AK316274.1 BC022868.1 L16464.1 

    4 DOTS entries:

    DT.95332215  DT.404458  DT.430587  DT.95254527 

    Selected AceView cDNA sequences (see all 30):

    AA947850 AF218540 BM666885 BX091144 BC022868 AI791558 AA948144 BM695111 
    AW059911 M78749 BU686728 L16464 AI793162 AI733068 AI733226 AL601147 
    BF087762 NM_005240 AV660485 BF176184 BG942091 AA915991 AV733666 AW893558 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TryGeneCards Plus

    ETV3 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TTTGCAGTGA
    ETV3 Expression
    About this image

    ETV3 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    ETV3 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.105636
        Custom PCR Arrays for ETV3
    Primer
    Products:
    OriGene qPCR primer pairs and template standards for ETV3
    OriGene qSTAR qPCR primer pairs in human, mouse for ETV3
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat ETV3
    QuantiTect SYBR Green Assays in human, mouse, rat ETV3
    QuantiFast Probe-based Assays in human, mouse, rat ETV3
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ETV3

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    TryGeneCards Plus

    This gene was present in the common ancestor of chordates.

    Orthologs for ETV3 gene from Selected species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Etv31 , 5 ets variant gene 31, 5 85.95(n)1
    86.67(a)1
      3 (38.19 cM)5
    270491  NM_001083318.21  NP_001076787.11 
     875254075 
    chicken
    (Gallus gallus)
    Aves ETV31 ets variant 3 74.11(n)
    77.87(a)
      426718  XM_424336.4  XP_424336.3 
    lizard
    (Anolis carolinensis)
    Reptilia ETV36
    ets variant 3
    67(a)
    1 ↔ 1
    GL343637.1(129325-145546)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.323262 Xenopus laevis transcribed sequence with moderate similarity more 83.37(n)    BJ626027.1 
    zebrafish
    (Danio rerio)
    Actinopterygii si:ch211-265g22.46
    erf6
    Ets2 repressor factor
    40(a)
    38(a)
    many ↔ many
    many ↔ many
    2(44427193-44432915) ENSDARG00000076512
    19(6764207-6815742) ENSDARG00000063417


    ENSEMBL Gene Tree for ETV3 (if available)
    TreeFam Gene Tree for ETV3 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

    TryGeneCards Plus
    Paralogs for ETV3 gene
    ETV12  ERF2  ETV52  ETV3L2  ETS12  GABPA2  ETS22  ERG2  
    FEV2  ETV42  ETV22  FLI12  
    2 SIMAP similar genes for ETV3 using alignment to 1 protein entry:     ETV3_HUMAN:
    ELF5    ERF

    Find genes that share paralogs with ETV3           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

    TryGeneCards Plus

    Selected SNPs for ETV3 (see all 221)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs3740065651,2
    C--157094013(+) AAAAA-/TGCCAAAC
    AACACCAACC
    AAAAA
    1 -- ds50010--------
    rs115891141,2
    H--157094051(+) aaaaaA/Ggaagg 1 -- ds5001 trp30--------
    rs676139871,2
    C--157094051(-) CCTTC-/C/T/TT
            
    TTTTT
    1 -- ds50011NA 2
    rs1813205291,2
    --157094072(+) AAGAGC/TAACAT 1 -- ds50010--------
    rs120280841,2
    H--157094120(+) ATTATC/GTTATT 1 -- ds50014Minor allele frequency- G:0.00NS EA 420
    rs1867401061,2
    --157094362(+) GAAAGC/TATAAG 1 -- ds50010--------
    rs1490365111,2
    C--157094381(+) GGAAAC/TAGAGG 1 -- ds50010--------
    rs1131169751,2
    F--157094483(+) AACCCG/CATCCC 1 -- ut312Minor allele frequency- C:0.50CSA 4
    rs741169871,2
    C,F--157094502(+) AACATG/AAAAAT 1 -- ut311Minor allele frequency- A:0.50WA 2
    rs626409441,2
    C,F--157094714(+) TCTCGG/AGCTTC 2 /A syn14Minor allele frequency- A:0.02NS WA NA EU 891

    HapMap Linkage Disequilibrium report for ETV3 (157090983 - 157108383 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for ETV3:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2718474CNV Deletion23290073
    nsv3121CNV Loss18451855

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing ETV3
    DNA2.0 Custom Variant and Variant Library Synthesis for ETV3

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TryGeneCards Plus
    OMIM gene information: 164873    OMIM disorders: --

    1 disease for ETV3:    
    About MalaCards
    brain cancer

    2 diseases from the University of Copenhagen DISEASES database for ETV3:
    Heart disease     Hypertension

    Find genes that share disorders with ETV3           About GenesLikeMe

    Genetic Association Database (GAD): ETV3

    Export disorders for ETV3 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    TryGeneCards Plus

    PubMed articles for ETV3 gene, integrated from 10 sources (see all 22):
    (articles sorted by number of sources associating them with ETV3)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. PE-1, a novel ETS oncogene family member, localizes to chromosome 1q21-q23. (PubMed id 8020980)1, 2, 3 Klemsz M.... Hoffman R. (Genomics 1994)
    2. Conduct disorder and ADHD: evaluation of conduct problems as a categorical and quantitative trait in the international multicentre ADHD genetics study. (PubMed id 18951430)1, 4 Anney R.J....Gill M. (Am. J. Med. Genet. B Neuropsychiatr. Genet. 2008)
    3. The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)1, 2 Gregory S.G.... Bentley D.R. (Nature 2006)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    5. An induced Ets repressor complex regulates growth arrest during terminal macrophage differentiation. (PubMed id 12007404)1, 2 Klappacher G.W.... Glass C.K. (Cell 2002)
    6. The SOX2-interactome in brain cancer cells identifies the requirement of MSI2 and USP9X for the growth of brain tumor cells. (PubMed id 23667531)1 Cox J.L....Rizzino A. (PLoS ONE 2013)
    7. Frequent copy number gains at 1q21 and 1q32 are associated with overexpression of the ETS transcription factors ETV3 and ELF3 in breast cancer irrespective of molecular subtypes. (PubMed id 23329352)1 Mesquita B....Teixeira M.R. (Breast Cancer Res. Treat. 2013)
    8. A Y2H-seq approach defines the human protein methyltransferase interactome. (PubMed id 23455924)1 Weimann M.... Stelzl U. (Nat. Methods 2013)
    9. Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass. (PubMed id 23000965)1 Povlsen L.K....Choudhary C. (Nat. Cell Biol. 2012)
    10. A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (amp 2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

    TryGeneCards Plus
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

    TryGeneCards Plus
    Entrez Gene: 2117 HGNC: 3492 AceView: ETV3 Ensembl:ENSG00000117036 euGenes: HUgn2117
    ECgene: ETV3 H-InvDB: ETV3

    (According to HUGE)
    About This Section

    TryGeneCards Plus
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

    TryGeneCards Plus
    NameDescription
    PharmGKB entry for ETV3 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for ETV3 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus
    Patent Information for ETV3 gene:
    Search GeneIP for patents involving ETV3

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

    TryGeneCards Plus

     
     EMD Millipore genomic analysis products

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Enzyme Activity Assays/Reagents  
     Browse ELISpot/FluoroSpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Luminex Assays  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Recombinant/Natural Proteins   Browse Stem Cell Products  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     Browse OriGene Antibodies   OriGene RNAi products in human, mouse, rat for ETV3  
     OriGene qPCR primer pairs and template standards for ETV3   OriGene Protein Over-expression Lysate for ETV3  
     OriGene Custom Mass Spec   OriGene clones in human, mouse for ETV3  
     OriGene qSTAR qPCR primer pairs in human, mouse for ETV3   Browse OriGene full length recombinant human proteins expressed in human HEK293 cells  
     OriGene ORF clones in mouse, rat for ETV3   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for ETV3   OriGene Custom Protein Services for ETV3  

     
     
     Block miRNA regulation of human, mouse, rat ETV3 using miScript Target Protectors SeqTarget long-range PCR primers for resequencing ETV3
     DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ETV3 Predesigned siRNA for gene silencing in human, mouse, rat ETV3
     QuantiFast Probe-based Assays in human, mouse, rat ETV3 QuantiTect SYBR Green Assays in human, mouse, rat ETV3
     Custom PCR Arrays for ETV3 Search Chromatin IP Primers for ETV3
     Pre-validated RT2 qPCR Primer Assay in human, mouse, rat ETV3  GeneGlobe Interaction Network for ETV3
     Regulatory tfbs in ETV3 promoter
     GenScript Custom Purified and Recombinant Proteins Services for ETV3 GenScript cDNA clones with any tag delivered in your preferred vector for ETV3
     GenScript Custom Assay Services for ETV3 GenScript Custom overexpressing Cell Line Services for ETV3
     CloneReady with Over 120,000 Genes  Gene Synthesis: Any Gene in Any Vector
     Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
     Plasmid Preparation Custom Peptide Services
     Search for Antibodies & Assays

     Search Tocris compounds for ETV3
     Browse Sino Biological Proteins
     Browse Sino Biological Cell Lysates
     Browse Sino Biological cDNA Clones
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

     Novus Tissue Slides
     ETV3 antibodies
     ETV3 proteins
     ETV3 lysates
     Antibodies for ETV3
     See all of Abcam's Antibodies, Kits and Proteins for ETV3
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins
     Proteins for ETV3
     Antibodies for ETV3
     ELISAs for ETV3
     CLIAs for ETV3



     Browse ESI BIO Cell Lines and PureStem Progenitors for ETV3
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ETV3
     SwitchGear 3'UTR luciferase reporter plasmids for ETV3
     SwitchGear Promoter luciferase reporter plasmids for ETV3
     Search ThermoFisher Antibodies for ETV3
     Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat ETV3
     inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for ETV3
     inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for ETV3
     LSBio Antibodies in human, mouse, rat for ETV3
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
     Browse compounds at ApexBio
     Search Addgene for plasmids for ETV3
      Search eBioscience for proteins for ETV3
      Search eBioscience for elisas for ETV3
      eBioscience FlowRNA Probe Sets
           
    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014 , 21 Aug 2014 , 8 Sep 2014

    View Random Gene

    Category
    (GIFtS: )
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      ETV3 gene at Home site.
    Version: 3.12.224 13 Oct 2014
    hostname: 356977-web1.xennexinc.com index build: 128 solr: 1.4