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Aliases for ETV3 Gene

Aliases for ETV3 Gene

  • ETS Variant 3 2 3
  • Ets Variant Gene 3, ETS Family Transcriptional Repressor 2 3
  • Mitogenic Ets Transcriptional Suppressor 3 4
  • ETS Domain Transcriptional Repressor PE1 3 4
  • PE-1 3 4
  • METS 3 4
  • PE1 3 4
  • Ets Variant 3 5
  • BA110J1.4 3

External Ids for ETV3 Gene

Previous GeneCards Identifiers for ETV3 Gene

  • GC01M154963
  • GC01M152859
  • GC01M153872
  • GC01M154311
  • GC01M153907
  • GC01M155357
  • GC01M128452

Summaries for ETV3 Gene

GeneCards Summary for ETV3 Gene

ETV3 (ETS Variant 3) is a Protein Coding gene. Diseases associated with ETV3 include subclavian steal syndrome. Among its related pathways are Macrophage Differentiation and Growth Inhibition by METS. GO annotations related to this gene include transcription factor activity, sequence-specific DNA binding and RNA polymerase II transcription factor activity, sequence-specific DNA binding. An important paralog of this gene is ETS2.

UniProtKB/Swiss-Prot for ETV3 Gene

  • Transcriptional repressor that contribute to growth arrest during terminal macrophage differentiation by repressing target genes involved in Ras-dependent proliferation. Represses MMP1 promoter activity.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ETV3 Gene

Genomics for ETV3 Gene

Regulatory Elements for ETV3 Gene

Promoters for ETV3 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around ETV3 on UCSC Golden Path with GeneCards custom track

Transcription factor binding sites by QIAGEN in the ETV3 gene promoter:

Genomic Location for ETV3 Gene

Chromosome:
1
Start:
157,121,191 bp from pter
End:
157,138,591 bp from pter
Size:
17,401 bases
Orientation:
Minus strand

Genomic View for ETV3 Gene

Genes around ETV3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ETV3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ETV3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ETV3 Gene

Proteins for ETV3 Gene

  • Protein details for ETV3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P41162-ETV3_HUMAN
    Recommended name:
    ETS translocation variant 3
    Protein Accession:
    P41162
    Secondary Accessions:
    • B4E3M7
    • Q8TAC8
    • Q9BX30

    Protein attributes for ETV3 Gene

    Size:
    512 amino acids
    Molecular mass:
    57001 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAA60949.1; Type=Frameshift; Positions=174; Evidence={ECO:0000305};

    Alternative splice isoforms for ETV3 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ETV3 Gene

Proteomics data for ETV3 Gene at MOPED

Post-translational modifications for ETV3 Gene

  • Ubiquitination at Lys 224
  • Modification sites at PhosphoSitePlus

Other Protein References for ETV3 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for ETV3 Gene

Domains & Families for ETV3 Gene

Gene Families for ETV3 Gene

Protein Domains for ETV3 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for ETV3 Gene

Graphical View of Domain Structure for InterPro Entry

P41162

UniProtKB/Swiss-Prot:

ETV3_HUMAN :
  • Contains 1 ETS DNA-binding domain.
  • Belongs to the ETS family.
Domain:
  • Contains 1 ETS DNA-binding domain.
Family:
  • Belongs to the ETS family.
genes like me logo Genes that share domains with ETV3: view

Function for ETV3 Gene

Molecular function for ETV3 Gene

GENATLAS Biochemistry:
ETS variant gene 3,expressed in numerous cell lines,divergent member of the winged helix-turn-helix superfamily
UniProtKB/Swiss-Prot Function:
Transcriptional repressor that contribute to growth arrest during terminal macrophage differentiation by repressing target genes involved in Ras-dependent proliferation. Represses MMP1 promoter activity.

Gene Ontology (GO) - Molecular Function for ETV3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000977 RNA polymerase II regulatory region sequence-specific DNA binding IEA --
GO:0001227 transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding IEA --
GO:0003674 molecular_function ND --
GO:0005515 protein binding IEA --
genes like me logo Genes that share ontologies with ETV3: view
genes like me logo Genes that share phenotypes with ETV3: view

Animal Model Products

miRNA for ETV3 Gene

miRTarBase miRNAs that target ETV3

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ETV3 Gene

Localization for ETV3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ETV3 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ETV3 Gene COMPARTMENTS Subcellular localization image for ETV3 gene
Compartment Confidence
nucleus 5
extracellular 2
cytosol 1

No data available for Gene Ontology (GO) - Cellular Components for ETV3 Gene

Pathways & Interactions for ETV3 Gene

genes like me logo Genes that share pathways with ETV3: view

Pathways by source for ETV3 Gene

Gene Ontology (GO) - Biological Process for ETV3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0008150 biological_process ND --
GO:0008285 negative regulation of cell proliferation IEA --
genes like me logo Genes that share ontologies with ETV3: view

No data available for SIGNOR curated interactions for ETV3 Gene

Drugs & Compounds for ETV3 Gene

No Compound Related Data Available

Transcripts for ETV3 Gene

Unigene Clusters for ETV3 Gene

Ets variant 3:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ETV3 Gene

No ASD Table

Relevant External Links for ETV3 Gene

GeneLoc Exon Structure for
ETV3
ECgene alternative splicing isoforms for
ETV3

Expression for ETV3 Gene

mRNA expression in normal human tissues for ETV3 Gene

Protein differential expression in normal tissues from HIPED for ETV3 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (41.3), CD8 Tcells (12.1), and Skin (8.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for ETV3 Gene



SOURCE GeneReport for Unigene cluster for ETV3 Gene Hs.105636

genes like me logo Genes that share expression patterns with ETV3: view

Protein tissue co-expression partners for ETV3 Gene

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for ETV3 Gene

Orthologs for ETV3 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ETV3 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia ETV3 35
  • 90.77 (n)
  • 92.14 (a)
ETV3 36
  • 92 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ETV3 35
  • 90.96 (n)
  • 93.12 (a)
ETV3 36
  • 88 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Etv3 35
  • 85.95 (n)
  • 86.67 (a)
Etv3 16
Etv3 36
  • 86 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia ETV3 35
  • 99.67 (n)
  • 99.41 (a)
ETV3 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Etv3 35
  • 86.86 (n)
  • 87.06 (a)
oppossum
(Monodelphis domestica)
Mammalia ETV3 36
  • 85 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia ETV3 36
  • 96 (a)
OneToOne
chicken
(Gallus gallus)
Aves ETV3 35
  • 74.11 (n)
  • 77.87 (a)
ETV3 36
  • 74 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia ETV3 36
  • 67 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia etv3 35
  • 66.74 (n)
  • 68.99 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.32326 35
zebrafish
(Danio rerio)
Actinopterygii erf 36
  • 38 (a)
ManyToMany
si:ch211-265g22.4 36
  • 40 (a)
ManyToMany
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.5256 35
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 36 (a)
OneToMany
Species with no ortholog for ETV3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ETV3 Gene

ENSEMBL:
Gene Tree for ETV3 (if available)
TreeFam:
Gene Tree for ETV3 (if available)

Paralogs for ETV3 Gene

Paralogs for ETV3 Gene

(2) SIMAP similar genes for ETV3 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with ETV3: view

Variants for ETV3 Gene

Sequence variations from dbSNP and Humsavar for ETV3 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs913083 -- 157,123,942(+) AAAAG(A/G)AAAAA utr-variant-3-prime
rs998842 -- 157,132,661(+) GTGGC(G/T)AGTAC intron-variant
rs985457 -- 157,138,195(+) CTGGG(C/T)GAGGC intron-variant
rs1177850 -- 157,121,291(+) AAAAa(A/T)atgta utr-variant-3-prime
rs1467661 -- 157,139,182(+) AAACG(C/G)GTGTC intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for ETV3 Gene

Variant ID Type Subtype PubMed ID
nsv3121 CNV Loss 18451855
esv2718474 CNV Deletion 23290073

Variation tolerance for ETV3 Gene

Gene Damage Index Score: 0.74; 15.74% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ETV3 Gene

HapMap Linkage Disequilibrium report
ETV3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ETV3 Gene

Disorders for ETV3 Gene

MalaCards: The human disease database

(1) MalaCards diseases for ETV3 Gene - From: DISEASES

Disorder Aliases PubMed IDs
subclavian steal syndrome
  • subclavian artery stenosis
- elite association - COSMIC cancer census association via MalaCards
Search ETV3 in MalaCards View complete list of genes associated with diseases

Relevant External Links for ETV3

Genetic Association Database (GAD)
ETV3
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ETV3
genes like me logo Genes that share disorders with ETV3: view

No data available for UniProtKB/Swiss-Prot and Genatlas for ETV3 Gene

Publications for ETV3 Gene

  1. PE-1, a novel ETS oncogene family member, localizes to chromosome 1q21-q23. (PMID: 8020980) Klemsz M. … Hoffman R. (Genomics 1994) 2 3 4 67
  2. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  3. Frequent copy number gains at 1q21 and 1q32 are associated with overexpression of the ETS transcription factors ETV3 and ELF3 in breast cancer irrespective of molecular subtypes. (PMID: 23329352) Mesquita B. … Teixeira M.R. (Breast Cancer Res. Treat. 2013) 3
  4. A Y2H-seq approach defines the human protein methyltransferase interactome. (PMID: 23455924) Weimann M. … Stelzl U. (Nat. Methods 2013) 3
  5. The SOX2-interactome in brain cancer cells identifies the requirement of MSI2 and USP9X for the growth of brain tumor cells. (PMID: 23667531) Cox J.L. … Rizzino A. (PLoS ONE 2013) 3

Products for ETV3 Gene

Sources for ETV3 Gene

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