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Aliases for ETV3 Gene

Aliases for ETV3 Gene

  • ETS Variant 3 2 3 5
  • Ets Variant Gene 3, ETS Family Transcriptional Repressor 2 3
  • Mitogenic Ets Transcriptional Suppressor 3 4
  • ETS Domain Transcriptional Repressor PE1 3 4
  • PE-1 3 4
  • METS 3 4
  • PE1 3 4
  • ETS Translocation Variant 3 3

External Ids for ETV3 Gene

Previous GeneCards Identifiers for ETV3 Gene

  • GC01M154963
  • GC01M152859
  • GC01M153872
  • GC01M154311
  • GC01M153907
  • GC01M155357
  • GC01M128452

Summaries for ETV3 Gene

GeneCards Summary for ETV3 Gene

ETV3 (ETS Variant 3) is a Protein Coding gene. Diseases associated with ETV3 include Subclavian Steal Syndrome. Among its related pathways are Macrophage Differentiation and Growth Inhibition by METS. GO annotations related to this gene include transcription factor activity, sequence-specific DNA binding and RNA polymerase II transcription factor activity, sequence-specific DNA binding. An important paralog of this gene is ERF.

UniProtKB/Swiss-Prot for ETV3 Gene

  • Transcriptional repressor that contribute to growth arrest during terminal macrophage differentiation by repressing target genes involved in Ras-dependent proliferation. Represses MMP1 promoter activity.

Additional gene information for ETV3 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ETV3 Gene

Genomics for ETV3 Gene

Regulatory Elements for ETV3 Gene

Enhancers for ETV3 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH01H157131 1.7 FANTOM5 ENCODE dbSUPER 33.2 +3.0 3031 8 HDGF PKNOX1 FOXA2 ARNT ARID4B SIN3A DMAP1 ZNF766 ZNF143 ZNF207 ETV3 RRNAD1 ETV3L CCT3 PRCC CYCSP52
GH01H157105 1.5 FANTOM5 Ensembl ENCODE 31 +32.0 31969 1 HDGF BMI1 BATF ZNF207 FOS ATF7 ETV6 RUNX3 CREM IKZF2 ETV3 BGLAP ARHGEF11 RRNAD1 ETV3L CYCSP52
GH01H157153 1.9 FANTOM5 Ensembl ENCODE dbSUPER 20.8 -16.5 -16498 3 ATF1 ZFP64 ARID4B ZNF2 ZNF766 GLIS2 GATA2 ZNF143 RUNX3 DEK ETV3 ETV3L RRNAD1 ENSG00000229961
GH01H156656 2.6 VISTA FANTOM5 Ensembl ENCODE dbSUPER 9.8 +474.3 474333 15 MLX ZFP64 DMAP1 ZNF416 ZNF143 SP3 MCM3 ZC3H11A SSRP1 ZNF610 GON4L KIAA0907 LOC246784 RRNAD1 PRCC MSTO2P LMNA ISG20L2 YY1AP1 TSACC
GH01H156740 1.9 FANTOM5 ENCODE dbSUPER 11.2 +391.7 391729 13 MLX DMAP1 YY1 SLC30A9 ZNF143 SP3 NFYC ZC3H11A MEF2D SSRP1 GON4L RRNAD1 KIAA0907 LOC246784 CCT3 SYT11 HDGF ISG20L2 LMNA TSACC
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around ETV3 on UCSC Golden Path with GeneCards custom track

Promoters for ETV3 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000014307 491 2201 HDGF PKNOX1 ARNT ARID4B SIN3A DMAP1 ZNF143 ZNF207 FOS SP3

Transcription factor binding sites by QIAGEN in the ETV3 gene promoter:

Genomic Location for ETV3 Gene

Chromosome:
1
Start:
157,121,191 bp from pter
End:
157,138,591 bp from pter
Size:
17,401 bases
Orientation:
Minus strand

Genomic View for ETV3 Gene

Genes around ETV3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ETV3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ETV3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ETV3 Gene

Proteins for ETV3 Gene

  • Protein details for ETV3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P41162-ETV3_HUMAN
    Recommended name:
    ETS translocation variant 3
    Protein Accession:
    P41162
    Secondary Accessions:
    • B4E3M7
    • Q8TAC8
    • Q9BX30

    Protein attributes for ETV3 Gene

    Size:
    512 amino acids
    Molecular mass:
    57001 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAA60949.1; Type=Frameshift; Positions=174; Evidence={ECO:0000305};

    Alternative splice isoforms for ETV3 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ETV3 Gene

Post-translational modifications for ETV3 Gene

  • Ubiquitination at posLast=224224
  • Modification sites at PhosphoSitePlus

Other Protein References for ETV3 Gene

No data available for DME Specific Peptides for ETV3 Gene

Domains & Families for ETV3 Gene

Gene Families for ETV3 Gene

HGNC:
Human Protein Atlas (HPA):
  • Plasma proteins
  • Predicted intracellular proteins
  • Transcription factors

Protein Domains for ETV3 Gene

Suggested Antigen Peptide Sequences for ETV3 Gene

Graphical View of Domain Structure for InterPro Entry

P41162

UniProtKB/Swiss-Prot:

ETV3_HUMAN :
  • Belongs to the ETS family.
Family:
  • Belongs to the ETS family.
genes like me logo Genes that share domains with ETV3: view

Function for ETV3 Gene

Molecular function for ETV3 Gene

GENATLAS Biochemistry:
ETS variant gene 3,expressed in numerous cell lines,divergent member of the winged helix-turn-helix superfamily
UniProtKB/Swiss-Prot Function:
Transcriptional repressor that contribute to growth arrest during terminal macrophage differentiation by repressing target genes involved in Ras-dependent proliferation. Represses MMP1 promoter activity.

Phenotypes From GWAS Catalog for ETV3 Gene

Gene Ontology (GO) - Molecular Function for ETV3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000977 RNA polymerase II regulatory region sequence-specific DNA binding IEA --
GO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding IBA --
GO:0001227 transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding IEA --
GO:0003674 molecular_function ND --
GO:0003677 DNA binding IEA --
genes like me logo Genes that share ontologies with ETV3: view
genes like me logo Genes that share phenotypes with ETV3: view

Animal Model Products

CRISPR Products

miRNA for ETV3 Gene

miRTarBase miRNAs that target ETV3

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for ETV3
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ETV3 Gene

Localization for ETV3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ETV3 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ETV3 gene
Compartment Confidence
nucleus 5
extracellular 2
cytosol 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for ETV3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000790 nuclear chromatin IEA --
GO:0005634 nucleus IBA --
GO:0017053 transcriptional repressor complex IEA --
GO:0090571 RNA polymerase II transcription repressor complex IEA --
genes like me logo Genes that share ontologies with ETV3: view

Pathways & Interactions for ETV3 Gene

genes like me logo Genes that share pathways with ETV3: view

Pathways by source for ETV3 Gene

Gene Ontology (GO) - Biological Process for ETV3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription from RNA polymerase II promoter IEA --
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0006357 regulation of transcription from RNA polymerase II promoter IBA --
GO:0008150 biological_process ND --
genes like me logo Genes that share ontologies with ETV3: view

No data available for SIGNOR curated interactions for ETV3 Gene

Drugs & Compounds for ETV3 Gene

No Compound Related Data Available

Transcripts for ETV3 Gene

Unigene Clusters for ETV3 Gene

Ets variant 3:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for ETV3
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for ETV3 Gene

No ASD Table

Relevant External Links for ETV3 Gene

GeneLoc Exon Structure for
ETV3
ECgene alternative splicing isoforms for
ETV3

Expression for ETV3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ETV3 Gene

Protein differential expression in normal tissues from HIPED for ETV3 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (41.3), CD8 Tcells (12.1), and Skin (8.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for ETV3 Gene



Protein tissue co-expression partners for ETV3 Gene

NURSA nuclear receptor signaling pathways regulating expression of ETV3 Gene:

ETV3

SOURCE GeneReport for Unigene cluster for ETV3 Gene:

Hs.105636

Evidence on tissue expression from TISSUES for ETV3 Gene

  • Nervous system(4.4)
  • Bone marrow(4.2)
  • Heart(3.4)
  • Muscle(2.7)
  • Blood(2.5)
genes like me logo Genes that share expression patterns with ETV3: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ETV3 Gene

Orthologs for ETV3 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ETV3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ETV3 33 34
  • 99.67 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia ETV3 34
  • 96 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ETV3 34 33
  • 90.96 (n)
OneToOne
cow
(Bos Taurus)
Mammalia ETV3 34 33
  • 90.77 (n)
OneToOne
rat
(Rattus norvegicus)
Mammalia Etv3 33
  • 86.86 (n)
mouse
(Mus musculus)
Mammalia Etv3 33 16 34
  • 85.95 (n)
oppossum
(Monodelphis domestica)
Mammalia ETV3 34
  • 85 (a)
OneToOne
chicken
(Gallus gallus)
Aves ETV3 33 34
  • 74.11 (n)
lizard
(Anolis carolinensis)
Reptilia ETV3 34
  • 67 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia etv3 33
  • 66.74 (n)
African clawed frog
(Xenopus laevis)
Amphibia Xl.32326 33
zebrafish
(Danio rerio)
Actinopterygii si:ch211-265g22.4 34
  • 40 (a)
ManyToMany
erf 34
  • 38 (a)
ManyToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 36 (a)
OneToMany
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.5256 33
Species where no ortholog for ETV3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ETV3 Gene

ENSEMBL:
Gene Tree for ETV3 (if available)
TreeFam:
Gene Tree for ETV3 (if available)

Paralogs for ETV3 Gene

Paralogs for ETV3 Gene

(2) SIMAP similar genes for ETV3 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with ETV3: view

Variants for ETV3 Gene

Sequence variations from dbSNP and Humsavar for ETV3 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs1000148307 -- 157,138,258(+) TCCCC(A/G)CCAGG intron-variant
rs1000194380 -- 157,121,374(+) GAAAG(C/T)GGAAC utr-variant-3-prime
rs1000276881 -- 157,132,273(+) GATCT(C/T)GAGCT intron-variant
rs1000422932 -- 157,124,335(+) TATTC(C/T)TTCCC downstream-variant-500B, utr-variant-3-prime
rs1000586929 -- 157,123,846(+) CAGAC(A/G)TAATG utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for ETV3 Gene

Variant ID Type Subtype PubMed ID
esv2718474 CNV deletion 23290073
nsv3121 CNV deletion 18451855
nsv946427 CNV duplication 23825009

Variation tolerance for ETV3 Gene

Gene Damage Index Score: 0.74; 15.74% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ETV3 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ETV3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ETV3 Gene

Disorders for ETV3 Gene

MalaCards: The human disease database

(1) MalaCards diseases for ETV3 Gene - From: DISEASES

Disorder Aliases PubMed IDs
subclavian steal syndrome
  • subclavian artery stenosis
- elite association - COSMIC cancer census association via MalaCards
Search ETV3 in MalaCards View complete list of genes associated with diseases

Relevant External Links for ETV3

Genetic Association Database (GAD)
ETV3
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ETV3
genes like me logo Genes that share disorders with ETV3: view

No data available for UniProtKB/Swiss-Prot and Genatlas for ETV3 Gene

Publications for ETV3 Gene

  1. PE-1, a novel ETS oncogene family member, localizes to chromosome 1q21-q23. (PMID: 8020980) Klemsz M … Hoffman R (Genomics 1994) 2 3 4 60
  2. Conduct disorder and ADHD: evaluation of conduct problems as a categorical and quantitative trait in the international multicentre ADHD genetics study. (PMID: 18951430) Anney RJ … Gill M (American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics 2008) 3 45 60
  3. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory SG … Prigmore E (Nature 2006) 3 4 60
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 60
  5. An induced Ets repressor complex regulates growth arrest during terminal macrophage differentiation. (PMID: 12007404) Klappacher GW … Glass CK (Cell 2002) 3 4 60

Products for ETV3 Gene

Sources for ETV3 Gene

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