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Aliases for ETV2 Gene

Aliases for ETV2 Gene

  • ETS Variant 2 2 3 5
  • Ets-Related Protein 71 3 4
  • Ets Variant Gene 2 2 3
  • ETSRP71 3 4
  • ER71 3 4
  • ETS Translocation Variant 2 3

External Ids for ETV2 Gene

Previous GeneCards Identifiers for ETV2 Gene

  • GC19U990034
  • GC19P036581
  • GC19P040809
  • GC19P040825
  • GC19P036132
  • GC19P032637
  • GC19P035695
  • GC19P035819
  • GC19P035843
  • GC19P035998
  • GC19P036165
  • GC19P036235
  • GC19P036407

Summaries for ETV2 Gene

GeneCards Summary for ETV2 Gene

ETV2 (ETS Variant 2) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include DNA binding transcription factor activity and RNA polymerase II proximal promoter sequence-specific DNA binding. An important paralog of this gene is FLI1.

UniProtKB/Swiss-Prot for ETV2 Gene

  • Binds to DNA sequences containing the consensus pentanucleotide 5-CGGA[AT]-3.

Additional gene information for ETV2 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ETV2 Gene

Genomics for ETV2 Gene

GeneHancer (GH) Regulatory Elements for ETV2 Gene

Promoters and enhancers for ETV2 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH19I035641 Promoter/Enhancer 2.5 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 576.7 +2.3 2317 4.6 MLX DMAP1 YY1 SLC30A9 ZNF213 E2F8 ZNF416 ZNF143 ZNF548 SP3 ETV2 KMT2B RBM42 TMEM147-AS1 PROSER3 ZNF792 ZNF529 ZNF566 HAUS5 ZNF181
GH19I035638 Enhancer 0.8 ENCODE 568 -2.0 -1951 0.7 ATF1 KLF17 FEZF1 GLIS2 ZNF302 ZNF366 ATF7 ZNF548 CREM ZNF362 ETV2 ZNF181 ZNF529 ZNF146 TMEM147-AS1 ZNF30 HAUS5 ZNF260 ZNF566 ZNF792
GH19I035946 Enhancer 1.5 FANTOM5 Ensembl ENCODE 33.8 +306.2 306180 0.8 HDGF ARNT ARID4B SIN3A FEZF1 ZNF2 IRF4 ZNF213 ZNF302 E2F8 LOC105372383 ZNF567 ZNF345 TMEM147-AS1 ZNF850 HAUS5 PROSER3 ZNF790 KMT2B ZNF529
GH19I035612 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 17.2 -28.4 -28406 1.5 ARID4B SIN3A FEZF1 DMAP1 ZNF2 YY1 POLR2B ZNF766 E2F8 ZNF207 HAUS5 ENSG00000267626 ZNF599 ZNF529 ZNF302 ZNF566 ZNF260 ZNF181 TMEM147-AS1 ZFP82
GH19I035627 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 14.6 -12.3 -12349 2.3 HDGF PKNOX1 SMAD1 MLX ARNT ARID4B SIN3A DMAP1 ZNF2 ZBTB7B RBM42 PIR55956 ZNF566 PROSER3 TMEM147-AS1 ZNF529 ZNF146 HAUS5 KMT2B ZFP82
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around ETV2 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the ETV2 gene promoter:

Genomic Locations for ETV2 Gene

Genomic Locations for ETV2 Gene
chr19:35,641,213-35,644,871
(GRCh38/hg38)
Size:
3,659 bases
Orientation:
Plus strand
chr19:36,132,647-36,135,773
(GRCh37/hg19)

Genomic View for ETV2 Gene

Genes around ETV2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ETV2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ETV2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ETV2 Gene

Proteins for ETV2 Gene

  • Protein details for ETV2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O00321-ETV2_HUMAN
    Recommended name:
    ETS translocation variant 2
    Protein Accession:
    O00321
    Secondary Accessions:
    • A6NFN5
    • B3KUL0
    • B9EIN1
    • Q9UEA0

    Protein attributes for ETV2 Gene

    Size:
    342 amino acids
    Molecular mass:
    36633 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAB57630.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

    Alternative splice isoforms for ETV2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ETV2 Gene

Post-translational modifications for ETV2 Gene

No Post-translational modifications

No data available for DME Specific Peptides for ETV2 Gene

Domains & Families for ETV2 Gene

Gene Families for ETV2 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Transcription factors

Protein Domains for ETV2 Gene

Suggested Antigen Peptide Sequences for ETV2 Gene

Graphical View of Domain Structure for InterPro Entry

O00321

UniProtKB/Swiss-Prot:

ETV2_HUMAN :
  • Belongs to the ETS family.
Family:
  • Belongs to the ETS family.
genes like me logo Genes that share domains with ETV2: view

Function for ETV2 Gene

Molecular function for ETV2 Gene

UniProtKB/Swiss-Prot Function:
Binds to DNA sequences containing the consensus pentanucleotide 5-CGGA[AT]-3.

Gene Ontology (GO) - Molecular Function for ETV2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000978 RNA polymerase II proximal promoter sequence-specific DNA binding IEA --
GO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding IBA --
GO:0001077 transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding IEA --
GO:0003677 DNA binding IEA --
GO:0003700 DNA binding transcription factor activity IEA --
genes like me logo Genes that share ontologies with ETV2: view
genes like me logo Genes that share phenotypes with ETV2: view

Animal Models for ETV2 Gene

MGI Knock Outs for ETV2:
Targeted motifs for ETV2 Gene
HOMER Transcription Factor Regulatory Elements motif ETV2
  • Consensus sequence: NNAYTTCCTGHN Submotif: canonical Cell Type: ES GEO ID: GSE59402

Clone Products

  • Addgene plasmids for ETV2

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , miRNA and Transcription Factor Targets for ETV2 Gene

Localization for ETV2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ETV2 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ETV2 gene
Compartment Confidence
nucleus 5
cytosol 2
extracellular 1

Gene Ontology (GO) - Cellular Components for ETV2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IBA --
genes like me logo Genes that share ontologies with ETV2: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for ETV2 Gene

Pathways & Interactions for ETV2 Gene

No Data Available

SIGNOR curated interactions for ETV2 Gene

Activates:

Gene Ontology (GO) - Biological Process for ETV2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001701 in utero embryonic development IEA --
GO:0001707 mesoderm formation IEA --
GO:0001824 blastocyst development IEA --
GO:0001890 placenta development IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
genes like me logo Genes that share ontologies with ETV2: view

No data available for Pathways by source for ETV2 Gene

Drugs & Compounds for ETV2 Gene

No Compound Related Data Available

Transcripts for ETV2 Gene

mRNA/cDNA for ETV2 Gene

(6) REFSEQ mRNAs :
(6) Additional mRNA sequences :
(8) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for ETV2 Gene

Ets variant 2:
Representative Sequences:

Clone Products

  • Addgene plasmids for ETV2

Alternative Splicing Database (ASD) splice patterns (SP) for ETV2 Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4 ^ 5a · 5b ^ 6a · 6b ^ 7 ^ 8a · 8b · 8c
SP1: -
SP2:
SP3: - - - - -
SP4:
SP5:
SP6:

Relevant External Links for ETV2 Gene

GeneLoc Exon Structure for
ETV2
ECgene alternative splicing isoforms for
ETV2

Expression for ETV2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ETV2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for ETV2 Gene

This gene is overexpressed in Testis (x18.9).

Protein differential expression in normal tissues from HIPED for ETV2 Gene

This gene is overexpressed in Platelet (68.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for ETV2 Gene



Protein tissue co-expression partners for ETV2 Gene

NURSA nuclear receptor signaling pathways regulating expression of ETV2 Gene:

ETV2

SOURCE GeneReport for Unigene cluster for ETV2 Gene:

Hs.194061

Evidence on tissue expression from TISSUES for ETV2 Gene

  • Heart(2.1)
genes like me logo Genes that share expression patterns with ETV2: view

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ETV2 Gene

Orthologs for ETV2 Gene

This gene was present in the common ancestor of animals.

Orthologs for ETV2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ETV2 33 34
  • 97.71 (n)
dog
(Canis familiaris)
Mammalia ETV2 33 34
  • 81.67 (n)
cow
(Bos Taurus)
Mammalia ETV2 33 34
  • 80.72 (n)
rat
(Rattus norvegicus)
Mammalia Etv2 33
  • 78.08 (n)
mouse
(Mus musculus)
Mammalia Etv2 33 16 34
  • 77.38 (n)
zebrafish
(Danio rerio)
Actinopterygii fli1b 34
  • 16 (a)
ManyToMany
fruit fly
(Drosophila melanogaster)
Insecta Ets65A 34
  • 16 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea ets-5 34
  • 26 (a)
ManyToMany
ast-1 34
  • 19 (a)
ManyToMany
Species where no ortholog for ETV2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for ETV2 Gene

ENSEMBL:
Gene Tree for ETV2 (if available)
TreeFam:
Gene Tree for ETV2 (if available)

Paralogs for ETV2 Gene

Paralogs for ETV2 Gene

genes like me logo Genes that share paralogs with ETV2: view

Variants for ETV2 Gene

Sequence variations from dbSNP and Humsavar for ETV2 Gene

SNP ID Clin Chr 19 pos Variation AA Info Type
rs1000151679 -- 35,640,711(+) G/A upstream_transcript_variant
rs1000248813 -- 35,645,030(+) T/C downstream_transcript_variant
rs1000249590 -- 35,644,869(+) C/G 3_prime_UTR_variant
rs1000478763 -- 35,639,391(+) T/C upstream_transcript_variant
rs1000712012 -- 35,639,205(+) G/C upstream_transcript_variant

Variation tolerance for ETV2 Gene

Residual Variation Intolerance Score: 81.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.84; 73.91% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ETV2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ETV2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for ETV2 Gene

Disorders for ETV2 Gene

Additional Disease Information for ETV2

No disorders were found for ETV2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ETV2 Gene

Publications for ETV2 Gene

  1. Interplay among Etsrp/ER71, Scl, and Alk8 signaling controls endothelial and myeloid cell formation. (PMID: 18270322) Sumanas S … Lin S (Blood 2008) 3 22 58
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  3. The DNA sequence and biology of human chromosome 19. (PMID: 15057824) Grimwood J … Lucas SM (Nature 2004) 3 4 58
  4. Specificities of protein-protein and protein-DNA interaction of GABP alpha and two newly defined ets-related proteins. (PMID: 1340465) Brown TA … McKnight SL (Genes & development 1992) 2 3 58
  5. Direct Reprogramming of Human Dermal Fibroblasts Into Endothelial Cells Using ER71/ETV2. (PMID: 28003219) Lee S … Yoon YS (Circulation research 2017) 3 58

Products for ETV2 Gene

  • Addgene plasmids for ETV2

Sources for ETV2 Gene

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