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Aliases for ETV2 Gene

Aliases for ETV2 Gene

  • ETS Variant 2 2 3 5
  • Ets-Related Protein 71 3 4
  • Ets Variant Gene 2 2 3
  • ETSRP71 3 4
  • ER71 3 4
  • ETS Translocation Variant 2 3

External Ids for ETV2 Gene

Previous GeneCards Identifiers for ETV2 Gene

  • GC19U990034
  • GC19P036581
  • GC19P040809
  • GC19P040825
  • GC19P036132
  • GC19P032637
  • GC19P035695
  • GC19P035819
  • GC19P035843
  • GC19P035998
  • GC19P036165
  • GC19P036235

Summaries for ETV2 Gene

GeneCards Summary for ETV2 Gene

ETV2 (ETS Variant 2) is a Protein Coding gene. GO annotations related to this gene include transcription factor activity, sequence-specific DNA binding and RNA polymerase II core promoter proximal region sequence-specific DNA binding. An important paralog of this gene is ETS2.

UniProtKB/Swiss-Prot for ETV2 Gene

  • Binds to DNA sequences containing the consensus pentanucleotide 5-CGGA[AT]-3.

Additional gene information for ETV2 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ETV2 Gene

Genomics for ETV2 Gene

Regulatory Elements for ETV2 Gene

Enhancers for ETV2 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH19H035946 1.6 FANTOM5 Ensembl ENCODE 33.8 +306.2 306180 0.8 HDGF ARNT ARID4B SIN3A FEZF1 ZNF2 ZNF302 ZNF416 ZNF143 ZNF548 ZNF567 ZNF345 ZNF850 TMEM147-AS1 PROSER3 HAUS5 ZNF790 ZNF529 KMT2B ZNF790-AS1
GH19H035641 1.7 FANTOM5 ENCODE dbSUPER 26.6 +2.3 2318 4.6 HDGF PKNOX1 MLX ARNT ARID4B SIN3A DMAP1 ZNF2 ZBTB7B YY1 KMT2B RBM42 TMEM147-AS1 PROSER3 ZNF792 HAUS5 ZNF529 ZNF566 ZNF181 ENSG00000267049
GH19H034972 2 FANTOM5 Ensembl ENCODE dbSUPER 10.9 -667.2 -667152 2.5 HDGF PKNOX1 ARID4B SIN3A ZNF2 YY1 SLC30A9 ZNF302 ZNF416 ZNF207 TMEM147-AS1 LSM14A PROSER3 ZNF599 ENSG00000267049 HAUS5 KIAA0355 ZNF181 KMT2B ZNF30
GH19H034994 2.1 FANTOM5 Ensembl ENCODE dbSUPER 10.1 -640.3 -640282 13.5 MLX YBX1 DMAP1 YY1 SLC30A9 ZNF416 ZNF548 SP3 ZC3H11A NFYC TMEM147-AS1 ZNF599 LSM14A HAUS5 KMT2B ZNF792 ZNF302 KIAA0355 PROSER3 RBM42
GH19H035609 1.3 FANTOM5 Ensembl ENCODE 15.3 -31.0 -31020 1.7 NR2F1 EBF1 ZNF560 ZNF121 POLR2A IKZF1 NBN ATF7 ETV6 MLLT1 ETV2 U2AF1L4 CD22 NFKBID HCST IGFLR1 ZBTB32 FXYD5 USF2 FFAR1
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around ETV2 on UCSC Golden Path with GeneCards custom track

Genomic Locations for ETV2 Gene

Genomic Locations for ETV2 Gene
chr19:35,641,213-35,644,871
(GRCh38/hg38)
Size:
3,659 bases
Orientation:
Plus strand
chr19:36,132,647-36,135,773
(GRCh37/hg19)

Genomic View for ETV2 Gene

Genes around ETV2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ETV2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ETV2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ETV2 Gene

Proteins for ETV2 Gene

  • Protein details for ETV2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O00321-ETV2_HUMAN
    Recommended name:
    ETS translocation variant 2
    Protein Accession:
    O00321
    Secondary Accessions:
    • A6NFN5
    • B3KUL0
    • B9EIN1
    • Q9UEA0

    Protein attributes for ETV2 Gene

    Size:
    342 amino acids
    Molecular mass:
    36633 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAB57630.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

    Alternative splice isoforms for ETV2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ETV2 Gene

Post-translational modifications for ETV2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for ETV2 Gene

Domains & Families for ETV2 Gene

Gene Families for ETV2 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Transcription factors

Protein Domains for ETV2 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for ETV2 Gene

Graphical View of Domain Structure for InterPro Entry

O00321

UniProtKB/Swiss-Prot:

ETV2_HUMAN :
  • Belongs to the ETS family.
Family:
  • Belongs to the ETS family.
genes like me logo Genes that share domains with ETV2: view

Function for ETV2 Gene

Molecular function for ETV2 Gene

UniProtKB/Swiss-Prot Function:
Binds to DNA sequences containing the consensus pentanucleotide 5-CGGA[AT]-3.

Gene Ontology (GO) - Molecular Function for ETV2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000978 RNA polymerase II core promoter proximal region sequence-specific DNA binding IEA --
GO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding IBA --
GO:0001077 transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding IEA --
GO:0003677 DNA binding IEA --
GO:0003700 transcription factor activity, sequence-specific DNA binding IEA --
genes like me logo Genes that share ontologies with ETV2: view
genes like me logo Genes that share phenotypes with ETV2: view

Animal Models for ETV2 Gene

MGI Knock Outs for ETV2:
Targeted motifs for ETV2 Gene
HOMER Transcription Factor Regulatory Elements motif ETV2
  • Consensus sequence: NNAYTTCCTGHN Submotif: canonical Cell Type: ES GEO ID: GSE59402

Clone Products

  • Addgene plasmids for ETV2

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , miRNA and Transcription Factor Targets for ETV2 Gene

Localization for ETV2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ETV2 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ETV2 gene
Compartment Confidence
nucleus 5
cytosol 2
extracellular 1

Gene Ontology (GO) - Cellular Components for ETV2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IBA --
genes like me logo Genes that share ontologies with ETV2: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for ETV2 Gene

Pathways & Interactions for ETV2 Gene

No Data Available

SIGNOR curated interactions for ETV2 Gene

Activates:

Gene Ontology (GO) - Biological Process for ETV2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001701 in utero embryonic development IEA --
GO:0001707 mesoderm formation IEA --
GO:0001824 blastocyst development IEA --
GO:0001890 placenta development IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
genes like me logo Genes that share ontologies with ETV2: view

No data available for Pathways by source for ETV2 Gene

Drugs & Compounds for ETV2 Gene

No Compound Related Data Available

Transcripts for ETV2 Gene

mRNA/cDNA for ETV2 Gene

(6) REFSEQ mRNAs :
(6) Additional mRNA sequences :
(8) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for ETV2 Gene

Ets variant 2:
Representative Sequences:

Clone Products

  • Addgene plasmids for ETV2

Alternative Splicing Database (ASD) splice patterns (SP) for ETV2 Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4 ^ 5a · 5b ^ 6a · 6b ^ 7 ^ 8a · 8b · 8c
SP1: -
SP2:
SP3: - - - - -
SP4:
SP5:
SP6:

Relevant External Links for ETV2 Gene

GeneLoc Exon Structure for
ETV2
ECgene alternative splicing isoforms for
ETV2

Expression for ETV2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ETV2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for ETV2 Gene

This gene is overexpressed in Testis (x18.9).

Protein differential expression in normal tissues from HIPED for ETV2 Gene

This gene is overexpressed in Platelet (68.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for ETV2 Gene



Protein tissue co-expression partners for ETV2 Gene

NURSA nuclear receptor signaling pathways regulating expression of ETV2 Gene:

ETV2

SOURCE GeneReport for Unigene cluster for ETV2 Gene:

Hs.194061

Evidence on tissue expression from TISSUES for ETV2 Gene

  • Heart(2.1)
genes like me logo Genes that share expression patterns with ETV2: view

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ETV2 Gene

Orthologs for ETV2 Gene

This gene was present in the common ancestor of animals.

Orthologs for ETV2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ETV2 33 34
  • 97.71 (n)
dog
(Canis familiaris)
Mammalia ETV2 33 34
  • 81.67 (n)
cow
(Bos Taurus)
Mammalia ETV2 33 34
  • 80.72 (n)
rat
(Rattus norvegicus)
Mammalia Etv2 33
  • 78.08 (n)
mouse
(Mus musculus)
Mammalia Etv2 33 16 34
  • 77.38 (n)
zebrafish
(Danio rerio)
Actinopterygii fli1b 34
  • 16 (a)
ManyToMany
fruit fly
(Drosophila melanogaster)
Insecta Ets65A 34
  • 16 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea ets-5 34
  • 26 (a)
ManyToMany
ast-1 34
  • 19 (a)
ManyToMany
Species where no ortholog for ETV2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for ETV2 Gene

ENSEMBL:
Gene Tree for ETV2 (if available)
TreeFam:
Gene Tree for ETV2 (if available)

Paralogs for ETV2 Gene

Paralogs for ETV2 Gene

genes like me logo Genes that share paralogs with ETV2: view

Variants for ETV2 Gene

Sequence variations from dbSNP and Humsavar for ETV2 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs1000151679 -- 35,640,711(+) TGGGC(A/G)ACAGA upstream-variant-2KB
rs1000248813 -- 35,645,030(+) AGGCC(C/T)GGATC downstream-variant-500B
rs1000249590 -- 35,644,869(+) CAAAC(C/G)TCTTC utr-variant-3-prime
rs1000478763 -- 35,639,391(+) GGAGA(C/T)GGGAA upstream-variant-2KB
rs1000712012 -- 35,639,205(+) TCTCT(C/G)ACGTC upstream-variant-2KB

Variation tolerance for ETV2 Gene

Residual Variation Intolerance Score: 81.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.84; 73.91% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ETV2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ETV2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for ETV2 Gene

Disorders for ETV2 Gene

Relevant External Links for ETV2

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ETV2

No disorders were found for ETV2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ETV2 Gene

Publications for ETV2 Gene

  1. Interplay among Etsrp/ER71, Scl, and Alk8 signaling controls endothelial and myeloid cell formation. (PMID: 18270322) Sumanas S … Lin S (Blood 2008) 3 22 60
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 60
  3. The DNA sequence and biology of human chromosome 19. (PMID: 15057824) Grimwood J … Lucas SM (Nature 2004) 3 4 60
  4. Specificities of protein-protein and protein-DNA interaction of GABP alpha and two newly defined ets-related proteins. (PMID: 1340465) Brown TA … McKnight SL (Genes & development 1992) 2 3 60
  5. Direct Reprogramming of Human Dermal Fibroblasts Into Endothelial Cells Using ER71/ETV2. (PMID: 28003219) Lee S … Yoon YS (Circulation research 2016) 3 60

Products for ETV2 Gene

  • Addgene plasmids for ETV2

Sources for ETV2 Gene

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