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Aliases for ETV2 Gene

Aliases for ETV2 Gene

  • Ets Variant 2 2 3
  • ETSRP71 3 4 6
  • Ets-Related Protein 71 3 4
  • Ets Variant Gene 2 2 3
  • ER71 3 4
  • ETS Translocation Variant 2 3

External Ids for ETV2 Gene

Summaries for ETV2 Gene

GeneCards Summary for ETV2 Gene

ETV2 (Ets Variant 2) is a Protein Coding gene. GO annotations related to this gene include sequence-specific DNA binding transcription factor activity and sequence-specific DNA binding. An important paralog of this gene is ETS2.

UniProtKB/Swiss-Prot for ETV2 Gene

  • Binds to DNA sequences containing the consensus pentanucleotide 5-CGGA[AT]-3.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ETV2 Gene

Genomics for ETV2 Gene

Genomic Location for ETV2 Gene

Start:
35,641,745 bp from pter
End:
35,644,871 bp from pter
Size:
3,127 bases
Orientation:
Plus strand

Genomic View for ETV2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ETV2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ETV2 Gene

Regulatory Elements for ETV2 Gene

Proteins for ETV2 Gene

  • Protein details for ETV2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O00321-ETV2_HUMAN
    Recommended name:
    ETS translocation variant 2
    Protein Accession:
    O00321
    Secondary Accessions:
    • A6NFN5
    • B3KUL0
    • B9EIN1
    • Q9UEA0

    Protein attributes for ETV2 Gene

    Size:
    342 amino acids
    Molecular mass:
    36633 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAB57630.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

    Alternative splice isoforms for ETV2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ETV2 Gene

Proteomics data for ETV2 Gene at MOPED

Post-translational modifications for ETV2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for ETV2 Gene

Domains for ETV2 Gene

Protein Domains for ETV2 Gene

InterPro:
ProtoNet:

UniProtKB/Swiss-Prot:

ETV2_HUMAN
Domain:
  • Contains 1 ETS DNA-binding domain.:
    • O00321
Family:
  • Belongs to the ETS family.:
    • O00321
genes like me logo Genes that share domains with ETV2: view

No data available for Gene Families for ETV2 Gene

Function for ETV2 Gene

Molecular function for ETV2 Gene

UniProtKB/Swiss-Prot Function: Binds to DNA sequences containing the consensus pentanucleotide 5-CGGA[AT]-3.

Gene Ontology (GO) - Molecular Function for ETV2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000978 RNA polymerase II core promoter proximal region sequence-specific DNA binding IEA --
GO:0000981 sequence-specific DNA binding RNA polymerase II transcription factor activity IBA --
GO:0001077 RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription IEA --
GO:0003700 sequence-specific DNA binding transcription factor activity --
GO:0043565 sequence-specific DNA binding --
genes like me logo Genes that share ontologies with ETV2: view
genes like me logo Genes that share phenotypes with ETV2: view

Animal Models for ETV2 Gene

MGI Knock Outs for ETV2:

No data available for Enzyme Numbers (IUBMB) , miRNA , Transcription Factor Targeting and HOMER Transcription for ETV2 Gene

Localization for ETV2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ETV2 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ETV2 Gene COMPARTMENTS Subcellular localization image for ETV2 gene
Compartment Confidence
nucleus 5
cytosol 2

Gene Ontology (GO) - Cellular Components for ETV2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IBA --
genes like me logo Genes that share ontologies with ETV2: view

Pathways for ETV2 Gene

SuperPathways for ETV2 Gene

No Data Available

Interacting Proteins for ETV2 Gene

Gene Ontology (GO) - Biological Process for ETV2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001701 in utero embryonic development --
GO:0001707 mesoderm formation --
GO:0001824 blastocyst development IEA --
GO:0001890 placenta development IEA --
GO:0006355 regulation of transcription, DNA-templated --
genes like me logo Genes that share ontologies with ETV2: view

No data available for Pathways by source for ETV2 Gene

Transcripts for ETV2 Gene

mRNA/cDNA for ETV2 Gene

(6) REFSEQ mRNAs :
(6) Additional mRNA sequences :
(8) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for ETV2 Gene

Ets variant 2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ETV2 Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4 ^ 5a · 5b ^ 6a · 6b ^ 7 ^ 8a · 8b · 8c
SP1: -
SP2:
SP3: - - - - -
SP4:
SP5:
SP6:

Relevant External Links for ETV2 Gene

GeneLoc Exon Structure for
ETV2
ECgene alternative splicing isoforms for
ETV2

Expression for ETV2 Gene

mRNA expression in normal human tissues for ETV2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for ETV2 Gene

This gene is overexpressed in Testis (18.9).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for ETV2 Gene

SOURCE GeneReport for Unigene cluster for ETV2 Gene Hs.194061

genes like me logo Genes that share expressions with ETV2: view

Orthologs for ETV2 Gene

This gene was present in the common ancestor of animals.

Orthologs for ETV2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ETV2 36
  • 97.71 (n)
  • 95.62 (a)
ETV2 37
  • 98 (a)
OneToOne
cow
(Bos Taurus)
Mammalia ETV2 36
  • 80.72 (n)
  • 71.08 (a)
ETV2 37
  • 71 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ETV2 36
  • 81.67 (n)
  • 73.24 (a)
ETV2 37
  • 68 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Etv2 36
  • 77.38 (n)
  • 69.67 (a)
Etv2 16
Etv2 37
  • 69 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Etv2 36
  • 78.08 (n)
  • 68.47 (a)
zebrafish
(Danio rerio)
Actinopterygii fli1b 37
  • 16 (a)
ManyToMany
fruit fly
(Drosophila melanogaster)
Insecta Ets65A 37
  • 16 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea ast-1 37
  • 19 (a)
ManyToMany
ets-5 37
  • 26 (a)
ManyToMany
Species with no ortholog for ETV2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for ETV2 Gene

ENSEMBL:
Gene Tree for ETV2 (if available)
TreeFam:
Gene Tree for ETV2 (if available)

Paralogs for ETV2 Gene

Paralogs for ETV2 Gene

genes like me logo Genes that share paralogs with ETV2: view

Variants for ETV2 Gene

Sequence variations from dbSNP and Humsavar for ETV2 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type MAF
rs2285418 -- 35,642,626(+) CCAAA(G/T)TAGGC utr-variant-5-prime, missense, reference
rs2285419 -- 35,643,306(+) CCGGG(A/G)ACTGG utr-variant-5-prime, missense, reference
rs3214104 -- 35,643,081(+) GGACT(-/G)GGGTC intron-variant
rs3835005 -- 35,644,377(+) AATCC(-/T)GCCCC intron-variant
rs4447555 -- 35,640,852(+) CTGTG(G/T)TTTTT upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for ETV2 Gene

Variant ID Type Subtype PubMed ID
nsv911629 CNV Loss 21882294

Relevant External Links for ETV2 Gene

HapMap Linkage Disequilibrium report
ETV2

Disorders for ETV2 Gene

No disorders were found for ETV2 Gene.

No data available for UniProtKB/Swiss-Prot for ETV2 Gene

Publications for ETV2 Gene

  1. Interplay among Etsrp/ER71, Scl, and Alk8 signaling controls endothelial and myeloid cell formation. (PMID: 18270322) Sumanas S. … Lin S. (Blood 2008) 3 23
  2. Specificities of protein-protein and protein-DNA interaction of GABP alpha and two newly defined ets-related proteins. (PMID: 1340465) Brown T.A. … McKnight S.L. (Genes Dev. 1992) 2 3
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  4. The DNA sequence and biology of human chromosome 19. (PMID: 15057824) Grimwood J. … Lucas S.M. (Nature 2004) 3 4
  5. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K. … Sugano S. (Genome Res. 2006) 3

Products for ETV2 Gene

Sources for ETV2 Gene

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