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Aliases for ETV2 Gene

Aliases for ETV2 Gene

  • ETS Variant 2 2 3
  • Ets-Related Protein 71 3 4
  • Ets Variant Gene 2 2 3
  • ETSRP71 3 4
  • ER71 3 4
  • Ets Variant 2 5

External Ids for ETV2 Gene

Previous GeneCards Identifiers for ETV2 Gene

  • GC19U990034
  • GC19P036581
  • GC19P040809
  • GC19P040825
  • GC19P036132
  • GC19P032637
  • GC19P035695
  • GC19P035819

Summaries for ETV2 Gene

GeneCards Summary for ETV2 Gene

ETV2 (ETS Variant 2) is a Protein Coding gene. GO annotations related to this gene include transcription factor activity, sequence-specific DNA binding and RNA polymerase II core promoter proximal region sequence-specific DNA binding. An important paralog of this gene is ETS2.

UniProtKB/Swiss-Prot for ETV2 Gene

  • Binds to DNA sequences containing the consensus pentanucleotide 5-CGGA[AT]-3.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ETV2 Gene

Genomics for ETV2 Gene

Regulatory Elements for ETV2 Gene

Enhancers for ETV2 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around ETV2 on UCSC Golden Path with GeneCards custom track

Genomic Location for ETV2 Gene

Chromosome:
19
Start:
35,641,213 bp from pter
End:
35,644,871 bp from pter
Size:
3,659 bases
Orientation:
Plus strand

Genomic View for ETV2 Gene

Genes around ETV2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ETV2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ETV2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ETV2 Gene

Proteins for ETV2 Gene

  • Protein details for ETV2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O00321-ETV2_HUMAN
    Recommended name:
    ETS translocation variant 2
    Protein Accession:
    O00321
    Secondary Accessions:
    • A6NFN5
    • B3KUL0
    • B9EIN1
    • Q9UEA0

    Protein attributes for ETV2 Gene

    Size:
    342 amino acids
    Molecular mass:
    36633 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAB57630.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

    Alternative splice isoforms for ETV2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ETV2 Gene

Proteomics data for ETV2 Gene at MOPED

Post-translational modifications for ETV2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for ETV2 Gene

Domains & Families for ETV2 Gene

Gene Families for ETV2 Gene

Protein Domains for ETV2 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for ETV2 Gene

Graphical View of Domain Structure for InterPro Entry

O00321

UniProtKB/Swiss-Prot:

ETV2_HUMAN :
  • Contains 1 ETS DNA-binding domain.
  • Belongs to the ETS family.
Domain:
  • Contains 1 ETS DNA-binding domain.
Family:
  • Belongs to the ETS family.
genes like me logo Genes that share domains with ETV2: view

Function for ETV2 Gene

Molecular function for ETV2 Gene

UniProtKB/Swiss-Prot Function:
Binds to DNA sequences containing the consensus pentanucleotide 5-CGGA[AT]-3.

Gene Ontology (GO) - Molecular Function for ETV2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding IBA --
GO:0043565 sequence-specific DNA binding IEA --
genes like me logo Genes that share ontologies with ETV2: view
genes like me logo Genes that share phenotypes with ETV2: view

Animal Models for ETV2 Gene

MGI Knock Outs for ETV2:

Animal Model Products

Targeted motifs for ETV2 Gene
HOMER Transcription Factor Regulatory Elements motif ETV2
  • Consensus sequence: NNAYTTCCTGHN Submotif: canonical Cell Type: ES GEO ID: GSE59402

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , miRNA and Transcription Factor Targets for ETV2 Gene

Localization for ETV2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ETV2 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ETV2 Gene COMPARTMENTS Subcellular localization image for ETV2 gene
Compartment Confidence
nucleus 5
cytosol 2
extracellular 1

No data available for Gene Ontology (GO) - Cellular Components for ETV2 Gene

Pathways & Interactions for ETV2 Gene

SuperPathways for ETV2 Gene

No Data Available

Interacting Proteins for ETV2 Gene

SIGNOR curated interactions for ETV2 Gene

Activates:

Gene Ontology (GO) - Biological Process for ETV2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001701 in utero embryonic development IEA --
GO:0001707 mesoderm formation IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0006357 regulation of transcription from RNA polymerase II promoter IBA --
GO:0007219 Notch signaling pathway IEA --
genes like me logo Genes that share ontologies with ETV2: view

No data available for Pathways by source for ETV2 Gene

Drugs & Compounds for ETV2 Gene

No Compound Related Data Available

Transcripts for ETV2 Gene

mRNA/cDNA for ETV2 Gene

(6) REFSEQ mRNAs :
(6) Additional mRNA sequences :
(8) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for ETV2 Gene

Ets variant 2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ETV2 Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4 ^ 5a · 5b ^ 6a · 6b ^ 7 ^ 8a · 8b · 8c
SP1: -
SP2:
SP3: - - - - -
SP4:
SP5:
SP6:

Relevant External Links for ETV2 Gene

GeneLoc Exon Structure for
ETV2
ECgene alternative splicing isoforms for
ETV2

Expression for ETV2 Gene

mRNA expression in normal human tissues for ETV2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for ETV2 Gene

This gene is overexpressed in Testis (x18.9).

Protein differential expression in normal tissues from HIPED for ETV2 Gene

This gene is overexpressed in Platelet (68.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for ETV2 Gene



SOURCE GeneReport for Unigene cluster for ETV2 Gene Hs.194061

genes like me logo Genes that share expression patterns with ETV2: view

Protein tissue co-expression partners for ETV2 Gene

Primer Products

No data available for mRNA Expression by UniProt/SwissProt for ETV2 Gene

Orthologs for ETV2 Gene

This gene was present in the common ancestor of animals.

Orthologs for ETV2 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia ETV2 35
  • 80.72 (n)
  • 71.08 (a)
ETV2 36
  • 71 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ETV2 35
  • 81.67 (n)
  • 73.24 (a)
ETV2 36
  • 68 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Etv2 35
  • 77.38 (n)
  • 69.67 (a)
Etv2 16
Etv2 36
  • 69 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia ETV2 35
  • 97.71 (n)
  • 95.62 (a)
ETV2 36
  • 98 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Etv2 35
  • 78.08 (n)
  • 68.47 (a)
zebrafish
(Danio rerio)
Actinopterygii fli1b 36
  • 16 (a)
ManyToMany
fruit fly
(Drosophila melanogaster)
Insecta Ets65A 36
  • 16 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea ast-1 36
  • 19 (a)
ManyToMany
ets-5 36
  • 26 (a)
ManyToMany
Species with no ortholog for ETV2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for ETV2 Gene

ENSEMBL:
Gene Tree for ETV2 (if available)
TreeFam:
Gene Tree for ETV2 (if available)

Paralogs for ETV2 Gene

Paralogs for ETV2 Gene

genes like me logo Genes that share paralogs with ETV2: view

Variants for ETV2 Gene

Sequence variations from dbSNP and Humsavar for ETV2 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs2285419 - 35,643,306(+) CCGGG(A/G)ACTGG intron-variant, reference, missense, utr-variant-5-prime
rs8101136 -- 35,639,382(+) GTCAC(A/G)GGAGG upstream-variant-2KB
rs67718470 -- 35,644,378(+) ATCCG(-/T)CCCCG intron-variant
rs140000431 -- 35,643,250(+) CCTCA(C/G/T)TCGGG intron-variant
rs140816113 -- 35,644,308(+) TGGAC(C/T)GGCAA reference, synonymous-codon

Structural Variations from Database of Genomic Variants (DGV) for ETV2 Gene

Variant ID Type Subtype PubMed ID
nsv911629 CNV Loss 21882294

Variation tolerance for ETV2 Gene

Residual Variation Intolerance Score: 81.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.84; 73.91% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for ETV2 Gene

Disorders for ETV2 Gene

Relevant External Links for ETV2

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ETV2

No disorders were found for ETV2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ETV2 Gene

Publications for ETV2 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 67
  2. Interplay among Etsrp/ER71, Scl, and Alk8 signaling controls endothelial and myeloid cell formation. (PMID: 18270322) Sumanas S. … Lin S. (Blood 2008) 3 23
  3. Specificities of protein-protein and protein-DNA interaction of GABP alpha and two newly defined ets-related proteins. (PMID: 1340465) Brown T.A. … McKnight S.L. (Genes Dev. 1992) 2 3
  4. ETS transcription factor ETV2 directly converts human fibroblasts into functional endothelial cells. (PMID: 25540418) Morita R. … Yoshimura A. (Proc. Natl. Acad. Sci. U.S.A. 2015) 3
  5. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K. … Sugano S. (Genome Res. 2006) 3

Products for ETV2 Gene

Sources for ETV2 Gene

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