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Aliases & Descriptions for ETV1
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc
, and/or 7Ensembl,
8miRBase) About This Section
|
| Aliases |
|---|
| DKFZp781L0674 2 | | ER81 1, 2, 3 | | MGC104699 2 | | MGC120533 2 | | MGC120534 2 |
| | | Descriptions |
|---|
| Protein ER81 3 | | ets variant 1 2 | | ets variant gene 1 1, 2 |
|
| | Search outside databases for aliases for ETV1 genePrevious GC identifers: GC07M013579 GC07M013679 GC07M013708 |
Summaries for ETV1(According to Entrez Gene,
Wikipedia's
Gene Wiki,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
| UniProtKB/Swiss-Prot: ETV1_HUMAN, P50549Function: Transcriptional activator that binds to DNA sequences containing the consensus pentanucleotide 5'-CGGA[AT]-3'Gene Wiki entry for ETV1 |
Genomic Location for ETV1
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to
UCSC and
Ensembl,
Transcription factor binding sites according to
SABiosciences) About This Section
| Genomic View: UCSC Golden Path with GeneCards custom track
Transcription factor binding sites upstream to the ETV1 gene 
Entrez Gene cytogenetic band: 7p21.3 Ensembl cytogenetic band: 7p21.2 HGNC cytogenetic band: 7p22ETV1 Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different)
 GeneLoc gene densities for chromosome 7 GeneLoc Exon Structure GeneLoc location for GC07M013897:
(about GC identifiers)
Start:
|
13,897,379 bp from pter |
End:
|
13,997,399 bp from pter |
Size:
|
100,021 bases |
Orientation:
|
minus strand |
1 alternative location:
| Chr7-,CRA_TCAG 13,981,766-14,079,660 |
RefSeq DNA sequence:- NC_000007.12 NT_007819.16 NT_079592.2
| Proteins for ETV1
(According to
1UniProtKB,
and/or Ensembl,
Phosphorylation sites according to 2Phosphosite,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from Invitrogen,
Millipore,
Sigma-Aldrich,
R&D Systems,
Enzo Life Sciences,
Abnova,
OriGene and/or,
Abcam,
Biochemical Assays by
Invitrogen,
Millipore,
R&D Systems,
Cell Signaling Technology, and/or
Enzo Life Sciences,
Ontologies according to Gene
Ontology Consortium 01 Apr 2009 and
Entrez Gene,
Antibodies by Invitrogen,
Millipore,
Sigma-Aldrich,
R&D Systems,
Cell Signaling Technology,
Abcam,
Abnova, and/or
Novus Biologicals)
About This Section
| UniProtKB/Swiss-Prot: ETV1_HUMAN, P50549 (See
protein sequence)Recommended Name: ETS translocation variant 1 Size: 477 amino acids; 55131 Da
Subcellular location: Nucleus (Probable)
Secondary accessions: A4D118 B2R768 O75849 Q4KMQ6 Q9UQ71 Q9Y636Alternative splicing: 2 isoforms: P50549-1 P50549-2 Post-translational modifications:
Sumoylated1
View phosphorylation sites using PhosphoSite2
REFSEQ proteins: NP_004947.2
ENSEMBL proteins: ENSP00000385381 ENSP00000384085 ENSP00000384138 ENSP00000385686 ENSP00000385551 ENSP00000242066 ENSP00000382294 ENSP00000340853 ENSP00000382293
Human Recombinant Proteins               OriGene Purified Recombinant Human Protein: ETV1 
1 Gene Ontology (GO) cellular component term (links to tree view): | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005634 | nucleus |
IEA | -- | About this table
Antibodies for ETV1: Assays for ETV1: | Protein
Domains/ Families for ETV1(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
| - Graphical View of Domain Structure for InterPro Entry P50549
ProtoNet protein and cluster: P50549 1 Blocks protein family: IPB006715 PEA3-type ETS-domain transcription factor
UniProtKB/Swiss-Prot: ETV1_HUMAN, P50549Similarity: Belongs to the ETS familySimilarity: Contains 1 ETS DNA-binding domain | Gene Function for ETV1
(According to MGI Jun 06 2009, UniProtKB,
IUBMB,and/or Genatlas,
shRNA from
OriGene,
Sigma-Aldrich, RNAi from
Sigma-Aldrich,
RNAi Products,
Clones, and
Q-PCR Products
from Invitrogen,
Millipore,
OriGene, and/or
Abnova,
siRNAs from
Applied Biosystems,
SYBR primers from OriGene,
Cell-based Assays from Millipore,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene.)
About This Section
|               OriGene 29mer shRNA kit in GFP-retroviral vector: NM_004956
Applied Biosystems Silencer® siRNAs for ETV1
Sigma-Aldrich siRNA for ETV1  Sigma-Aldrich shRNA for ETV1  Explore Sigma-Aldrich super-pooled esiRNAs 
              OriGene GFP tagged cDNA clone in CMV expression vector: NM_004956                                  Myc/DDK tagged cDNA clone in CMV expression vector: NM_004956                                  untagged cDNA clone in CMV expression vector: NM_004956 
Primers: Browse
Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers               OriGene genome-wide validated SYBR primer pairs: NM_004956
UniProtKB/Swiss-Prot: ETV1_HUMAN, P50549Function: Transcriptional activator that binds to DNA sequences containing the consensus pentanucleotide 5'-CGGA[AT]-3'Genatlas biochemistry entry for ETV1:ETS variant 1,transcription factor of the ETS family,divergent member of the winged helix-turn-helix superfamily,fused with EWS in translocation t(7;22)(p22;q12)5 MGI mutant phenotypes (inferred from 5 alleles ) (MGI details for Etv1):
2 Gene Ontology (GO) molecular function terms (links to tree view): | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0003700 | transcription factor activity |
TAS | 7700648 | | GO:0043565 | sequence-specific DNA binding |
IEA | -- | About this table | Pathways & Interactions for ETV1
(Pathways according to Invitrogen
(maps by GeneGo),
Millipore,
Cell Signaling Technology,
Sigma-Aldrich,
KEGG
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Proteins Network according to
SABiosciences,
Interactions according to 1UniProtKB,
2MINT, and/or
3STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene.)
About This Section
|
Gene Network CentralTM Interacting Genes and Proteins Network for ETV1 
5/30 Interacting proteins for ETV1 (ENSP000002420663) via UniProtKB, MINT, and/or STRING (see all 30
)About this table
3 Gene Ontology (GO) biological process terms (links to tree view): | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0006350 | transcription |
IEA | -- | | GO:0006355 | regulation of transcription, DNA-dependent |
IEA | -- | | GO:0006366 | transcription from RNA polymerase II promoter |
TAS | 7700648 | About this table
|
Drugs & Compounds for ETV1(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
Sigma-Aldrich, Tocris Bioscience, and/or
Novoseek and Drugs according to
Enzo Life Sciences and/or
PharmGKB)
About This Section
|
Browse Tocris compounds for ETV1 1 Novoseek chemical compound relationship for ETV1 gene
| Compound |
Score |
Articles |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| tyrosine |
0.00 |
1 |
14747462 (1) |
About this table
|
Transcripts for ETV1(GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 219 Homo sapiens; Jun 2 2009) or GenBank, RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
non coding RNAs according to
RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from Invitrogen,
Millipore, and/or
Abnova,
siRNAs from Applied Biosystems,
Sigma-Aldrich,
shRNA from
Sigma-Aldrich,
OriGene,
Tagged/untagged cDNA clones from
OriGene, Expression Assays from Applied Biosystems) About This Section
|               OriGene 29mer shRNA kit in GFP-retroviral vector: NM_004956
Sigma-Aldrich siRNA for ETV1  Sigma-Aldrich shRNA for ETV1  Explore Sigma-Aldrich super-pooled esiRNAs 
Applied Biosystems Silencer® siRNAs: NM_004956 REFSEQ mRNAs for ETV1 gene: NM_004956.3
Applied Biosystems TaqMan ® Gene Expression Assays: NM_004956               OriGene GFP tagged cDNA clone in CMV expression vector: NM_004956                                  Myc/DDK tagged cDNA clone in CMV expression vector: NM_004956                                  untagged cDNA clone in CMV expression vector: NM_004956  Additional cDNA sequence: AB209202.1 AF070641.1 AJ012492.1 AK055368.1 AK293802.1 AK294572.1 AK294755.1 AK299693.1 AK309190.1 AK311089.1 AK311134.1 AK311194.1 AK311707.1 AK312863.1 AK316007.1 BC042950.2 BC045776.1 BC098403.1 BC106762.1 BC106763.1 CR627389.1 EF632110.1 U17163.1 X87175.1 12 DOTS entries: DT.100718526 DT.209406 DT.101979255 DT.121042940 DT.121042939 DT.121042925 DT.40129275 DT.65285559 DT.95117185 DT.100680153 DT.121042928 DT.121042952 24/127 AceView cDNA sequences (see all 127
):AL120951 BX282221 AF070641 AI870855 BQ894857 AI537939 BU681598 AI291719 AA593775 AI918670 NM_004956 AI801685 AI696120 AA486926 BG779436 BF222787 BE671608 BM698730 AI589102 BF110168 BF593408 AW274929 AI655920 AI637775
highest scoring ESTs for ETV1:BC045776 U17163 X87175 AA630663 AB209202 AF070641 AI640634 AU123808 BC098403 BI546256 Unigene Cluster for ETV1: Ets variant 1 Hs.22634 [show with all ESTs]Unigene Representative Sequence: NM_004956
GeneLoc Exon Structure
5/8 Alternative Splicing Database (ASD) splice patterns (SP) for ETV1 (see all 8
)
| ExUns: | 1 | ^ | 2 | ^ | 3a | · | 3b | · | 3c | ^ | 4a | · | 4b | ^ | 5a | · | 5b | ^ | 6a | · | 6b | ^ | 7 | ^ | 8 | ^ | 9 | ^ | 10a | · | 10b | ^ | 11 | ^ | 12 | ^ | 13 | ^ | 14 | ^ | 15a | · | 15b | ^ | 16a | · | 16b | ^ | 17a | · | 17b | |
| SP1: | |   | |   | |   | |   | |   | |   | |   | |   | |   | - |   | |   | |   | |   | - |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | - |   | |   | |   | |
| SP2: | |   | |   | |   | |   | |   | - |   | - |   | |   | |   | - |   | |   | |   | |   | - |   | |   | |   | |   | |   | - |   | |   | |   | |   | |   | - |   | |   | |   | |
| SP3: | |   | |   | |   | |   | |   | |   | |   | |   | |   | - |   | |   | |   | - |   | - |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | - |   | |   | |   | |
| SP4: | |   | - |   | - |   | - |   | - |   | |   | |   | |   | |   | - |   | |   | |   | |   | - |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |
| SP5: | |   | |   | |   | |   | |   | |   | |   | |   | |   | - |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   |
About this scheme
ECgene alternative splicing isoforms for ETV1
9 Ensembl transcripts including schematic representations: ENST00000405192
ENST00000405358
ENST00000403527
ENST00000403685
ENST00000405218
ENST00000242066
ENST00000399359
ENST00000343495
ENST00000399357
|
Expression for ETV1
(Experimental results according to
1GeneNote
and GNF BioGPS,
probe sets-to-genes annotations according to
2GeneAnnot ,
3GeneTide ,
Sets of similar genes according to GeneDecks,
Electronic Northern calculations according to data from
UniGene (Build 219 Homo sapiens),
SAGE tags according to
CGAP,
plus additional links to
SOURCE, and/or
GNF
BioGPS, and/or
EXPOLDB, and/or
UniProtKB,
Expression Assays from
Applied Biosystems
)
About This Section
| ETV1 expression in normal and diseased human tissues
Applied Biosystems TaqMan ® Gene Expression Assays for ETV1
1 / 2 / 3 14 probe-sets matching ETV1 gene Data from
(Publications) and GNF BioGPS About these images About these images
CGAP SAGE TAG: CTAACGTTAT
SOURCE GeneReport for Unigene cluster: Hs.22634
Expression variation in blood from EXPOLDB for ETV1 UniProtKB/Swiss-Prot: ETV1_HUMAN, P50549Tissue specificity: Very highly expressed in brain, highly expressed in testis, lung and heart, moderately in spleen, small intestine, pancreas and colon, weakly in liver, prostate and thymus, very weakly in skeletal muscle, kidney and ovary and not in placenta and peripheral blood leukocytes |
Orthologs for ETV1
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
and/or
5MGI Jun 06 2009,
with possible further links to
Flybase
and/or
WormBase,
Gene Trees according to Ensembl)
About This Section
|
Orthologs for ETV1 gene from 5/11 species (see all 11
)
About this table Species with no ortholog for ETV1
ENSEMBL Gene Tree for ETV1 | Paralogs for ETV1(Paralogs according to 1HomoloGene and 2Ensembl, Pseudogenes according to 3Pseudogene.org) About This Section
| Paralogs for ETV1 gene
- ETV42 ETV52
|
SNPs/Variants for ETV1(According to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE, and
UniProtKB,
Linkage Disequilibrium by HapMap,
Genotyping Reagents from
Applied Biosystems)
About This Section
|
HapMap Linkage Disequilibrium images for ETV1 (up to first 250kb)
|
Disorders & Mutations for ETV1
(in which this Gene is Involved, According to
OMIM, UniProtKB,
Novoseek, PharmGKB,
Genatlas, GeneTests,
Blood group antigen gene mutations by BGMUT,
HGMD, GAD,
HuGE Navigator,
BCGD,
and/or TGDB.)
About This Section
|
OMIM: 600541
UniProtKB/Swiss-Prot: ETV1_HUMAN, P50549
A chromosomal aberration involving ETV1 is a cause of Ewing sarcoma [MIM:133450]. Translocation t(7;22)(p22;q12) with EWS7 Novoseek disease relationships for ETV1 gene
| Disease |
Score |
Articles |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| ewings sarcoma |
64.54 |
5 |
7700648 (1), 7493135 (1), 10597226 (1) |
| prostate cancer |
59.60 |
48 |
17505060 (5), 16254181 (3), 18996329 (3), 17671502 (3) (see all 17) |
| tumors |
35.80 |
22 |
18726892 (3), 18996329 (2), 7493135 (1), 11593430 (1) (see all 10) |
| metastasis |
27.81 |
4 |
11593430 (1), 17505060 (1) |
| cancer |
25.65 |
4 |
15094065 (1), 19066166 (1), 8597501 (1) |
| mammary tumor |
25.33 |
1 |
12569367 (1) |
| breast cancer |
12.11 |
7 |
18628953 (1), 18726892 (1), 14673140 (1), 8597501 (1) |
About this table
Human Genome Epidemiology Navigator: ETV1 (2 documents)
|
Medical News for ETV1(Possibly Related Articles in
Doctor's Guide)
About This Section
| -- |
Publications for ETV1 (in
PubMed.
Associations of this gene to articles via
1Novoseek,
2HGNC,
3Entrez Gene,
4UniProtKB/Swiss-Prot,
5UniProtKB/TrEMBL,
6GAD, and/or
7PharmGKB)
About This Section
| 10/77 PubMed articles for ETV1 gene (see all 77
):- Molecular characterization of the ets-related human transcription factor ER81. (PubMed id 7651741)1, 3, 4 Monte D....de Launoit Y. (1995)
- A variant Ewing's sarcoma translocation (7;22) fuses the EWS gene to the ETS gene ETV1. (PubMed id 7700648)1, 3, 4 Jeon I.-S.... Shapiro D.N. (1995)
- Systematic identification and analysis of mammalian small ubiquitin- like modifier substrates. (PubMed id 15561718)3, 4 Gocke C.B.... Kang J. (2005)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)3, 4 Ota T....Sugano S. (2004)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)3, 4 Gerhard D.S....Malek J. (2004)
- Human chromosome 7: DNA sequence and biology. (PubMed id 12690205)3, 4 Scherer S.W....Tsui L.C. (2003)
- The DNA sequence of human chromosome 7. (PubMed id 12853948)3, 4 Hillier L.W.... Wilson R.K. (2003)
- Specificities of protein-protein and protein-DNA interaction of GABP alpha and two newly defined ets-related proteins. (PubMed id 1340465)2, 3 Brown T.A. and McKnight S.L. (1992)
- ETV1 is a novel androgen receptor-regulated gene that mediates prostate cancer cell invasion. (PubMed id 17505060)1, 3 Cai C....Shemshedini L. (2007)
- Rcl is a novel ETV1/ER81 target gene upregulated in breast tumors. (PubMed id 18726892)1, 3 Shin S.... Janknecht R. (2008)
|
Search for ETV1
(in PubMed,
OMIM, and NCBI Bookshelf) About This Section
|
|
Genome Databases showing ETV1
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
and/or
H-InvDB)
About This Section
|
| Other Databases showing ETV1
(According to HUGE)
About This Section
| -- |
Specialized Databases showing ETV1(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL, Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot) About This Section
|
| About This Section
| --
| Services for ETV1(Reagents available from Applied Biosystems, Antibodies and assays by Cell
Signaling Technology, Abcam, Novus Biologicals, Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich, Enzo Life Sciences, and/or Tocris Bioscience) About This Section
| 
 Products for ETV1:

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| | Recombinant Proteins (ER81) | | Antibodies (ER81) |
| | | Search Tocris compounds for ETV1 |
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GeneCards Homepage - Last full update: 2 Jul 2009
Incremental update: 13 Oct 2009
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