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ETS2 Gene

protein-coding GIFtS: 66

GC21P039099

v-ets erythroblastosis virus E26 oncogene homolog 2 (avian)
(Previous name: v-ets avian erythroblastosis virus E26 oncogene homolog 2 )
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase, and/or ⁹Nature:405,311-319 and CroW21)
About This Section

Aliases
ETS2IT1 ^²
OTTHUMP00000115973 ^²

Descriptions
human erythroblastosis virus oncogene homolog 2 ⁹
oncogene ETS-2 ^²
v-ets avian erythroblastosis virus E2 oncogene homolog 2 ^²
v-ets avian erythroblastosis virus E26 oncogene homolog 2 ^¹, ²
v-ets erythroblastosis virus E26 oncogene homolog 2 ^²
v-ets erythroblastosis virus E26 oncogene homolog 2 (avian) ^²

External Ids
HGNC: 3489¹
Entrez Gene: 2114²
UniProtKB: P15036³
Ensembl: ENSG00000157557⁷

Search outside databases for aliases for ETS2 gene

Previous GC identifers: GC21P036755 GC21P039097 GC21P039098

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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EntrezGene summary for ETS2:

ETS transcriptions factors, such as ETS2, regulate numerous genes and are involved in stem cell

development, cell senescence and death, and tumorigenesis. The conserved ETS domain within these

proteins is a winged helix-turn-helix DNA-binding domain that recognizes the core consensus DNA

sequence GGAA/T of target genes (Dwyer et al., 2007 [PubMed 17986575]).[supplied by OMIM]

Gene Wiki entry for ETS2

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences, Whole Chromsome Sequence According to Nature (Cited Here with Permission):405,311-319 and CroW21)
About This Section

Genomic View:

UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 21q22.3|21q22.2 Ensembl cytogenetic band: 21q22.2 HGNC cytogenetic band: 21q22.3
Nature(405: 311-319) cytogenetic band: 21q22.2

ETS2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 21 GeneLoc Exon Structure

(about GC identifiers)

GC21P039099:	GeneLoc	Nature:405,311-319
Start:	39,099,101 bp from pter	25,754,197 bp from centromere
End:	39,118,749 bp from pter	25,771,822 bp from centromere
Size:	19,649 bases	17,626 bases
Orientation:	plus strand	plus strand

RefSeq DNA sequence:

NC_000021.7 NT_011512.10

Whole chromosome sequencing:
cDNA sequence:	J04102
genomic clones:	Q109A8 KUD94C10

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
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UniProtKB/Swiss-Prot: ETS2_HUMAN, P15036 (See protein sequence)

Recommended Name: Protein C-ets-2

Size: 469 amino acids; 53001 Da

Subcellular location: Nucleus

Secondary accessions: A6NM68 Q53Y89

Post-translational modifications:

View phosphorylation sites using PhosphoSite²

REFSEQ proteins: NP_005230.1

ENSEMBL proteins:

ENSP00000353344 ENSP00000354194

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Browse Purified and Recombinant Proteins at Millipore
	Browse Human Recombinant Proteins at Sigma-Aldrich
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Recombinant Proteins from Abcam (ETS2, ETS2.3)
	Human Recombinant Proteins from Abnova (ETS2)

OriGene Purified Recombinant Human Protein: ETS2

1 Gene Ontology (GO) cellular component term (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005634	nucleus	IDA	16780588

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Antibodies for ETS2:

	Browse Antibodies Central at Invitrogen
	Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	Sigma-Aldrich Antibodies for ETS2
	Browse R&D Systems for Antibodies
	Antibodies from Abcam (ETS2, ETS2.3), each with their Abpromise^SM
	Monoclonal and Polyclonal Antibodies from Abnova (ETS2)
	Novus Biologicals Antibodies for ETS2

Assays for ETS2:

	Browse Invitrogen for biochemical assays
	Browse Kits and Assays available from Millipore
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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Graphical View of Domain Structure for InterPro Entry P15036

ProtoNet protein and cluster: P15036

1 Blocks protein family: IPB003118 Sterile alpha motif (SAM)/Pointed domain

UniProtKB/Swiss-Prot: ETS2_HUMAN, P15036

Similarity: Belongs to the ETS family

Similarity: Contains 1 ETS DNA-binding domain

Similarity: Contains 1 PNT (pointed) domain

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (ETS2)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (ETS2)

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_005239

Applied Biosystems Silencer® siRNAs for ETS2

Sigma-Aldrich siRNA for ETS2

Sigma-Aldrich shRNA for ETS2

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Invitrogen Clones for ETS2
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clone in CMV expression vector: NM_005239
Myc/DDK tagged cDNA clone in CMV expression vector: NM_005239
untagged cDNA clone in CMV expression vector: NM_005239

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_005239

Genatlas biochemistry entry for ETS2:

avian erythroblastosis virus E26 (v-ets) oncogene homolog 2,activating stromelysin-1 (MMP3) and

collagenase 1 (MMP8) promoters,likely involved in skeletal development,required to maintain the

transformed state of human prostate cancer cells

9 MGI mutant phenotypes (inferred from 5 alleles) (MGI details for Ets2):

embryogenesis	endocrine/exocrine gland	growth/size	lethality-prenatal/perinatal	normal
reproductive system	skin/coat/nails	touch/vibrissae	tumorigenesis

3 Gene Ontology (GO) molecular function terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0003700	transcription factor activity	NAS	8596630
GO:0005515	protein binding	IPI	18242510 18598946
GO:0043565	sequence-specific DNA binding	IEA	--

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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2 Sigma-Aldrich "Your Favorite Gene" Pathways for ETS2 (Your Favorite Gene powered by Ingenuity)

HGF Signaling
ERK/MAPK Signaling

GeneDecks ETS2 for the pathways selected above

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Gene Network Central^TM Interacting Genes and Proteins Network for ETS2

5/67 Interacting proteins for ETS2 (ENSP00000353344³ P15036^{1, 2}) via UniProtKB, MINT, and/or STRING (see all 67 )

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
CDK10	Q15131¹	STRING (score=.993) EBI-1646991, EBI-1646959
TWIST1	Q15672¹	EBI-1646991, EBI-1797287
TWIST2	Q8WVJ9¹	EBI-1646991, EBI-1797313
ZFYVE9	O95405²	MINT-62043
FOS	ENSP00000306245³	STRING (score=.989)

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2 Gene Ontology (GO) biological process terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0001501	skeletal system development	TAS	8596630
GO:0045893	positive regulation of transcription, DNA-dependent	IDA	11909962

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(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences

Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for ETS2
7 Novoseek chemical compound relationships for ETS2 gene

Compound	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
oligonucleotide	28.39	1	15314206 (1)
phorbol	21.06	2	10454570 (1), 16909100 (1)
pd 98,059	20.99	1	12511603 (1)
threonine	10.63	6	8552081 (4), 12511603 (1)
matrigel	9.49	2	9500466 (1), 11114728 (1)
superoxide	0.00	3	2045100 (1), 9918849 (1), 1347193 (1)
steroid	0.00	1	14722092 (1)

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(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (ETS2)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (ETS2)

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_005239

Sigma-Aldrich siRNA for ETS2

Sigma-Aldrich shRNA for ETS2

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_005239

REFSEQ mRNAs for ETS2 gene:

NM_005239.4

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_005239

              OriGene GFP tagged cDNA clone in CMV expression vector: NM_005239
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_005239
                                 untagged cDNA clone in CMV expression vector: NM_005239

Additional cDNA sequence:

AK000535.1 AK096841.1 AK315563.1 BC017040.1 BC042954.2 BT006838.1 CR608636.1 J04102.1

M11922.1

23 DOTS entries:

DT.219182 DT.97769195 DT.95160856 DT.100882674 DT.91743735 DT.70103366 DT.100882668 DT.100882694

DT.40107483 DT.91943112 DT.95160842 DT.95252128 DT.100703665 DT.100882693 DT.121136434 DT.40107484

DT.95160841 DT.95186047 DT.99973753 DT.100668345 DT.92446739 DT.95272179 DT.95290582

24/513 AceView cDNA sequences (see all 513 ):

AI621305 AA904183 BF590508 BM353061 BI827178 CD365380 AL552226 AI859056

AI636343 AI346854 BC017040 AA923572 CB529855 CA407009 H15859 BG259639

BM023098 D20617 AW294279 AA782270 N95783 CB269392 AK000535 BF940784

highest scoring ESTs for ETS2:

J04102 AA035720 AA037869 AA040934 AA054964 AA055499 AA055500 AA062906 AA151234 AA151235

Unigene Cluster for ETS2:

V-ets erythroblastosis virus E26 oncogene homolog 2 (avian)

Hs.644231 [show with all ESTs]

Unigene Representative Sequence: NM_005239

GeneLoc Exon Structure

5/7 Alternative Splicing Database (ASD) splice patterns (SP) for ETS2 (see all 7 )

ExUns:	1a	·	1b	·	1c	^	2a	·	2b	·	2c	^	3	^	4	^	5	^	6	^	7a	·	7b	^	8a	·	8b	·	8c	^	9	^	10a	·	10b	^	11	^	12	^	13	^	14a	·	14b
SP1:							-		-				-		-
SP2:													-		-
SP3:
SP4:					-		-		-		-		-		-
SP5:																							-		-

About this scheme

ECgene alternative splicing isoforms for ETS2

2 Ensembl transcripts including schematic representations:

ENST00000360214 ENST00000360938

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
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ETS2 expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for ETS2

¹ / ² / ³

9 probe-sets matching ETS2 gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
38739_at²^{, 3}	U95-A	1	1.00	1.00	0.94	1.14	AF017257	0.20	1.00	0.72	1
1519_at²^{, 3}	U95-A	1	1.00	1.00	0.93	1.50	J04102	1.00	1.00	1.00	1
68652_at*²^{, 3}	U95-E	1	1.00	1.00	0.19	0.39	AI431778	0.60	1.00	0.82	1
201329_s_at²^{, 3}	U133-A	1	1.00	1.00	--	--	NM_005239	0.60	1.00	0.82	1
201328_at²^{, 3}	U133-A	1	1.00	1.00	--	--	AL575509	0.80	1.00	0.91	1
222303_at*²^{, 3}	U133-A	1	1.00	1.00	--	--	AV700891	0.40	1.00	0.76	1
201329_s_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
201328_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
222303_at*²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--

GeneDecks ETS2 for binary patterns associated with the probe-sets selected above

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Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: GTAATAAACA

SOURCE GeneReport for Unigene cluster: Hs.644231
Expression variation in blood from EXPOLDB for ETS2

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for ETS2 gene from 5/10 species (see all 10 )

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	ETS2¹	--	v-ets erythroblastosis virus E26 oncogene homolog 2 more	88.84(n) 92.11(a)	487761 XM_854540.1 XP_859633.1
chimpanzee (Pan troglodytes)	ETS2¹	--	v-ets erythroblastosis virus E26 oncogene homolog 2 more	99.57(n) 100(a)	473996 XM_001170891.1 XP_001170891.1
cow (Bos taurus)	ETS2¹	--	v-ets erythroblastosis virus E26 oncogene homolog 2 more	87.27(n) 91.46(a)	281148 XM_594132.3 XP_594132.3
rat (Rattus norvegicus)	Ets2¹	--	v-ets erythroblastosis virus E26 oncogene homolog 2 more	86.71(n) 92.11(a)	304063 XM_239510.4 XP_239510.4
mouse (Mus musculus)	Ets2^{1, 5}	16 (69.60 cM)⁵	E26 avian leukemia oncogene 2, 3' domain^{1, 5}	85.87(n)¹ 91.86(a)¹	23872¹ NM_011809.2¹ NP_035939.2¹ AK005402⁵ AK014602⁵ (see all 30)

About this table Species with no ortholog for ETS2

ENSEMBL Gene Tree for ETS2

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
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Paralogs for ETS2 gene

ELK1² GABPA² ETS1²

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
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10/178 NCBI SNPs in ETS2 are shown (see all 178 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 79)

AB	SNP ID	Valid	Chr 21 pos	Sequence	Recs	AA Chg	Type	More	Recs	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--			--
	rs1051476^1,2	A,C,F,H	39117706(+)	`GACCAC/GCCAGC`	1	--	ut3¹ ese³		5	MN EU EA WA	584
	rs1051420^1,2	A,C,F,H	39117334(+)	`AGAGAA/CGTTGT`	1	--	ut3¹		9	MN EU EA WA	1022
	rs11254^1,2	A,C,F,H	39118258(+)	`AAAGTC/TCGACA`	1	--	ut3¹ ese³		13	MN EU EA WA NA	1384
	rs2283638^1,2	A,C,F,H	39097981(+)	`CGACTC/AAGGGA`	1	--	ng5¹		4	EA WA	1584
	rs2283639^1,2	A,C,F,H	39098563(+)	`CTTCCC/TGGTGG`	1	--	ng5¹ trp³		8	EU EA WA	834
	rs7282723^1,2	A,C,F,H	39118857(+)	`TCAAGC/TGGCAA`	1	--	ng3¹		8	EU EA WA	838
--	rs711^1,2	A,C,F	39116929(+)	`GCACCG/AGGAAG`	1	--	ut3¹ ese³		1	MN	184
	rs1051475^1,2	A,C,F	39117698(+)	`CTCTCT/CCTGAC`	1	--	ut3¹		1	MN	184
	rs530^1,2	A,C,F	39117147(-)	`ATTATT/AATAAT`	1	--	ut3¹		1	MN	184
	rs1051425^1,2	A,C,F	39117355(+)	`TTATTC/TACATT`	1	--	ut3¹		1	MN	184

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HapMap Linkage Disequilibrium images for ETS2 (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
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OMIM: 164740

10/20 Novoseek disease relationships for ETS2 gene (see all 20 )

Disease	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
erythroblastosis	72.57	4	2149958 (1), 17921261 (1), 12532432 (1), 16395289 (1)
choriocarcinoma	56.83	11	12511603 (2), 15637148 (2), 11689681 (1)
down syndrome	54.52	18	8596630 (3), 9918849 (2), 2149958 (1), 9315229 (1) (see all 10)
leukemia	27.42	4	2149958 (1), 2189104 (1), 18958307 (1), 2250910 (1)
breast cancer	14.82	11	16380248 (2), 15806151 (2), 12628005 (1), 15788656 (1) (see all 8)
tumors	12.30	19	16240325 (4), 2149958 (2), 9605774 (2), 18958307 (2) (see all 10)
breast carcinoma	11.46	4	14990565 (1), 16380248 (1), 9500466 (1), 15387369 (1)
necrosis	5.34	1	16142752 (1)
rheumatoid arthritis	1.75	2	11248661 (1), 8660103 (1)
glioblastoma	1.27	1	7523384 (1)

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1 PharmGKB disease relationship for ETS2 gene

Disease	PharmGKB Relations	PubMed IDs for articles supporting these relationships
Leukemia, Lymphocytic, Acute, L1	FA GN	12086872

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Tumor Gene Database: ETS2

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
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10/195 PubMed articles for ETS2 gene (see all 195 ):

Molecular organization and differential polyadenylation sites of the human ETS2 gene. (PubMed id 2250910)^{1, 3, 4} Watson D.K....Papas T.S. (1990)
Transcriptional regulation of telomerase activity: roles of the the Ets transcription factor family. (PubMed id 17986575)^{2, 3} Dwyer J....Liu J.P. (2007)
Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)^{3, 4} Ota T....Sugano S. (2004)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{3, 4} Gerhard D.S....Malek J. (2004)
The DNA sequence of human chromosome 21. (PubMed id 10830953)^{3, 4} Hattori M....Yaspo M.L. (2000)
Mammalian ets-1 and ets-2 genes encode highly conserved proteins. (PubMed id 2847145)^{3, 4} Watson D.K.... Papas T.S. (1988)
The ets sequence from the transforming gene of avian erythroblastosis virus, E26, has unique domains on human chromosomes 11 and 21: both loci are transcriptionally active. (PubMed id 2997781)^{3, 4} Watson D.K.... Papas T.S. (1985)
CD13/APN transcription is induced by RAS/MAPK-mediated phosphorylation of Ets-2 in activated endothelial cells. (PubMed id 14507917)^{1, 3} Petrovic N....Shapiro L.H. (2003)
Overexpression of ETS2 in human esophageal squamous cell carcinoma. (PubMed id 12532432)^{1, 3} Li X....Liu Z.H. (2003)
A central role for Ets-2 in the transcriptional regulation and cyclic adenosine 5'-monophosphate responsiveness of the human chorionic gonadotropin-beta subunit gene. (PubMed id 12511603)^{1, 3} Ghosh D....Roberts R.M. (2003)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
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Entrez Gene: 2114	HGNC: 3489	AceView: ETS2	Ensembl:ENSG00000157557	euGenes: HUgn2114
ECgene: ETS2	H-InvDB: ETS2

(According to HUGE)
About This Section

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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Name	Description
ATLAS Chromosomes in Cancer entry for ETS2	Genetics and Cytogenetics in Oncology and Haematology

Licensable Technologies for ETS2
(Available from WIS Yeda, Salk, Tufts)

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(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
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Products for ETS2:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for ETS2-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for ETS2		Antibodies for ETS2
	Explore super-pooled esiRNAs		Browse proteins at Sigma-Aldrich
	Lentivirus-delivered shRNAs for ETS2		Browse small molecules at Sigma-Aldrich
	"Your Favorite Gene" Pathways		feedback

	Antibodies		Primer Pairs
	Cell Culture Products		ELISAs
	Flow Cytometry Kits		Protease Activity Assays & Reagents
	Cell Selection/Detection Kits & Reagents		ELISA/Assay Development Kits & Reagents
	Multiplex/Array Assay Kits & Reagents		ELISpot Kits & Development Modules
	Recombinant & Natural Proteins

	Recombinant Proteins (ETS2)
	Antibodies (ETS2)
	Chimera RNAi (ETS2)
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	Custom Service for Rabbit Pab from Full-length Protein

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	Recombinant Proteins (ETS2, ETS2.3)
	Antibodies (ETS2, ETS2.3)

	Tagged/untagged cDNA clones
	Validated SYBR primer pairs
	Purified proteins from HEK293T cells
	Western blot validated antibodies
	shRNA in GFP-retroviral vector

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Antibodies for ETS2

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Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

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ETS2 Gene at Home site.
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ETS2 Gene

protein-coding GIFtS: 66

Aliases &
Descriptions
for ETS2

Summaries
for ETS2

Genomic Location
for ETS2

Proteins
for ETS2

Protein Domains/
Families
for ETS2

Gene Function
for ETS2

Pathways & Interactions
for ETS2

Drugs & Compounds
for ETS2

Transcripts
for ETS2

Expression
for ETS2

Orthologs
for ETS2

Paralogs
for ETS2

SNPs/Variants
for ETS2

Disorders & Mutations
for ETS2

Medical News
for ETS2

Publications
for ETS2

Search for ETS2

Genome Databases showing ETS2

Other Databases showing ETS2

Specialized Databases showing ETS2

Licensable Technologies
for ETS2

Services
for ETS2

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

ETS2 Gene

protein-coding GIFtS: 66

Aliases & Descriptionsfor ETS2

Summariesfor ETS2

Genomic Locationfor ETS2

Proteinsfor ETS2

Protein Domains/Familiesfor ETS2

Gene Functionfor ETS2

Pathways & Interactionsfor ETS2

Drugs & Compoundsfor ETS2

Transcriptsfor ETS2

Expression for ETS2

Orthologsfor ETS2

Paralogsfor ETS2

SNPs/Variantsfor ETS2

Disorders & Mutationsfor ETS2

Medical Newsfor ETS2

Publicationsfor ETS2

Search for ETS2

Genome Databases showing ETS2

Other Databases showing ETS2

Specialized Databases showing ETS2

Licensable Technologiesfor ETS2

Servicesfor ETS2

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for ETS2

Summaries
for ETS2

Genomic Location
for ETS2

Proteins
for ETS2

Protein Domains/
Families
for ETS2

Gene Function
for ETS2

Pathways & Interactions
for ETS2

Drugs & Compounds
for ETS2

Transcripts
for ETS2

Expression
for ETS2

Orthologs
for ETS2

Paralogs
for ETS2

SNPs/Variants
for ETS2

Disorders & Mutations
for ETS2

Medical News
for ETS2

Publications
for ETS2

Licensable Technologies
for ETS2

Services
for ETS2