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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

ETS2 Gene

protein-coding   GIFtS: 63
GCID: GC21P040177

v-ets erythroblastosis virus E26 oncogene homolog 2 (avian)

(Previous name: v-ets avian erythroblastosis virus E26 oncogene homolog...)
 Explore 40 diseases affiliated with
ETS2 via
MalaCards
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 Human Malady Compendium 
Biological research products
for ETS2    

Aliases
for ETS2 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, and/or 11Nature:405,311-319 and CroW21)
About This Section
Aliases
V-Ets Erythroblastosis Virus E26 Oncogene Homolog 2 (Avian)1 2     Oncogene ETS-22
V-Ets Avian Erythroblastosis Virus E26 Oncogene Homolog 21 2     Protein C-Ets-22
Human Erythroblastosis Virus Oncogene Homolog 211     V-Ets Avian Erythroblastosis Virus E2 Oncogene Homolog 22
ETS2IT12     

External Ids:    HGNC: 34891   Entrez Gene: 21142   Ensembl: ENSG000001575577   OMIM: 1647405   UniProtKB: P150363   

Export aliases for ETS2 gene to outside databases

Previous GC identifers: GC21P036755 GC21P039097 GC21P039098 GC21P039099 GC21P025647


Summaries
for ETS2 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for ETS2:
This gene encodes a transcription factor which regulates genes involved in development and apoptosis. The encoded
protein is also a protooncogene and shown to be involved in regulation of telomerase. A pseudogene of this gene is
located on the X chromosome. Alternative splicing results in multiple transcript variants. (provided by RefSeq, Jan
2012)

Gene Wiki entry for ETS2


Genomic Views
for ETS2 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics, Whole Chromsome Sequence According to Nature (Cited Here with Permission):405,311-319 and CroW21)
About This Section
RefSeq DNA sequence:
NC_000021.8  NC_018932.1  NT_011512.11  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the ETS2 gene promoter:
         GR   C/EBPbeta   p53   GR-beta   GATA-1   CREB   deltaCREB   GR-alpha   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 4): ETS2 promoter sequence

   Search SABiosciences Chromatin IP Primers for ETS2

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ETS2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 21q22.2   Ensembl cytogenetic band:  21q22.2   HGNC cytogenetic band: 21q22.3
Nature(405: 311-319) cytogenetic band:   21q22.2
ETS2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ETS2 gene location
GeneLoc information about chromosome 21         GeneLoc Exon Structure

(about GC identifiers)
GC21P040177:   GeneLoc Nature:405,311-319
Start:
 40,177,231 bp from pter       25,754,197 bp from centromere
End:
 40,196,879 bp from pter 25,771,822 bp from centromere
Size:
 19,649 bases 17,626 bases
Orientation:
 plus strand plus strand

Whole chromosome sequencing:
cDNA sequence: J04102
genomic clones: Q109A8 KUD94C10


Proteins
for ETS2 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: ETS2_HUMAN, P15036 (See protein sequence)
Recommended Name: Protein C-ets-2  
Size: 469 amino acids; 53001 Da
Subcellular location: Nucleus
Secondary accessions: A6NM68 D3DSH6 Q53Y89

Explore the universe of human proteins at neXtProt for ETS2: NX_P15036

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_P15036

    • ETS2 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins (2 alternative transcripts): 
    NP_001243224.1  NP_005230.1  

    ENSEMBL proteins: 
     ENSP00000353344   ENSP00000354194   ENSP00000401273   ENSP00000411086  

    Human Recombinant Protein Products: 
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    Novus Biologicals ETS2 Proteins
    Novus Biologicals ETS2 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for ETS2

    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA16780588


    ETS2 for ontologies           About GeneDecksing



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    Uscn ELISAs and CLIAs for ETS2

    Protein Domains /
    Families
    for ETS2 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    ETS2 for domains           About GeneDecksing

    5/6 InterPro domains/families (see all 6):
     IPR016311 Transform_prot_C-ets
     IPR000418 Ets_dom
     IPR027276 Transform_prot_C-ets-2
     IPR011991 WHTH_trsnscrt_rep_DNA-bd_dom
     IPR003118 Pointed_dom

    Graphical View of Domain Structure for InterPro Entry P15036

    ProtoNet protein and cluster: P15036

    1 Blocks protein family: IPB003118 Sterile alpha motif (SAM)/Pointed domain

    UniProtKB/Swiss-Prot: ETS2_HUMAN, P15036
    Similarity: Belongs to the ETS family
    Similarity: Contains 1 ETS DNA-binding domain
    Similarity: Contains 1 PNT (pointed) domain


    Function
    for ETS2 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:
         Genatlas biochemistry entry for ETS2:
    avian erythroblastosis virus E26 (v-ets) oncogene homolog 2,activating stromelysin-1 (MMP3) and collagenase 1 (MMP8)
    promoters,likely involved in skeletal development,required to maintain the transformed state of human prostate cancer
    cells

    miRNA
    Products:            		miRTarBase miRNAs that target ETS2:
    hsa-mir-199b-3p (MIRT004399), hsa-mir-199a-5p (MIRT004398)

    OriGene 3'-UTR Clone: ETS2
    Browse MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat ETS2
    8/49 QIAGEN miScript miRNA Assays for microRNAs that regulate ETS2 (see all 49):
    hsa-miR-607 hsa-miR-429 hsa-miR-300 hsa-miR-605 hsa-miR-1260b hsa-miR-507 hsa-miR-3921 hsa-miR-570
    SwitchGear 3'UTR luciferase reporter plasmid: ETS2 3' UTR sequence
    Inhib. RNA
    Products:            		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for ETS2 (see all 7)
    OriGene shRNA RFP: ETS2
    OriGene siRNA: ETS2
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ETS2

    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for ETS2

    Clone
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ETS2 

    Cell Line
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    Search LifeMap BioReagents cell lines for ETS2

    In Situ Assay
    Products:       
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ETS2

    Gene Ontology (GO): 5/7 molecular function terms (GO ID links to tree view) (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000977RNA polymerase II regulatory region sequence-specific DNA binding IEA--
    GO:0003677DNA binding TAS10918595
    GO:0003700sequence-specific DNA binding transcription factor activity IDA11909962
    GO:0005515protein binding IPI11909962
    GO:0016563transcription activator activity ----


    ETS2 for ontologies           About GeneDecksing


    Animal Models:
         Mouse knock-outs for ETS2: Ets2tm5.2Rgo Ets2tm1Rgo Ets2tm3.1Rgo
         9 MGI mutant phenotypes (inferred from 6 alleles) (MGI details for Ets2):
     cardiovascular system  embryogenesis  endocrine/exocrine gland  growth/size  homeostasis/metabolism 
     integument  mortality/aging  normal  tumorigenesis 

    ETS2 for phenotypes           About GeneDecksing


    Pathways & Interactions
    for ETS2 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways - 5/10 super-pathways (see all 10) About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Oct4 in Mammalian ESC Pluripotency
    		Oct4 in Mammalian ESC Pluripotency1.00
    2MIF Action Through Endocytic Pathway
    		MIF Action Through Endocytic Pathway1.00
    3IL-2 Signaling Pathway
    		IL-2 Signaling Pathway1.00
    4C-MYB transcription factor network
    		C-MYB transcription factor network1.00
    5Dorso-ventral axis formation
    		Dorso-ventral axis formation1.00

    Pathway sources
    See GeneCards unified pathways
    Show all pathways

    5/6 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for ETS2 (see all 6)
        Nur77-Induced AICD in Macrophage
    ERK Signaling
    HGF Pathway
    Oct4 in Mammalian ESC Pluripotency
    MIF Action Through Endocytic Pathway

    3 BioSystems Pathways for ETS2 
        Myometrial Relaxation and Contraction Pathways
    IL-2 Signaling Pathway
    C-MYB transcription factor network


    1         Kegg Pathway  (Kegg details for ETS2):
        Dorso-ventral axis formation


    ETS2 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for ETS2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/38 Interacting proteins for ETS2 (P150361, 2, 3 ENSP000003533444) via UniProtKB, MINT, STRING, and/or I2D (see all 38)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ZFYVE9O954052, 3MINT-62043 I2D: score=3 
    CDK10Q151311, 3, ENSP000003386734EBI-1646991,EBI-1646959 I2D: score=3 STRING: ENSP00000338673
    TWIST1Q156721, 3, ENSP000002422614EBI-1646991,EBI-1797287 I2D: score=1 STRING: ENSP00000242261
    TWIST2Q8WVJ91, 3, ENSP000004051764EBI-1646991,EBI-1797313 I2D: score=1 STRING: ENSP00000405176
    JUNP054123, ENSP000003602664I2D: score=3 STRING: ENSP00000360266
    About this table

    Gene Ontology (GO): 4 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001501skeletal system development TAS8596630
    GO:0006355regulation of transcription, DNA-dependent ----
    GO:0045893positive regulation of transcription, DNA-dependent IDA11909962
    GO:0045944positive regulation of transcription from RNA polymerase II promoter IEA--


    ETS2 for ontologies           About GeneDecksing



    Drugs & Compounds
    for ETS2 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    ETS2 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for ETS2
    10/11 Novoseek chemical compound relationships for ETS2 gene (see all 11)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    oligonucleotide 27 1 15314206 (1)
    phorbol 20.1 2 10454570 (1), 16909100 (1)
    pd 98,059 19.2 1 12511603 (1)
    threonine 8.98 6 8552081 (4), 12511603 (1)
    matrigel 7.19 2 9500466 (1), 11114728 (1)
    agar 5.96 3 9500466 (2), 2149958 (1)
    steroid 0 1 14722092 (1)
    superoxide 0 3 2045100 (1), 9918849 (1), 1347193 (1)
    alanine 0 2 8552081 (2)
    estrogen 0 1 1347193 (1)

    Search CenterWatch for drugs/clinical trials and news about ETS2 

    Transcripts
    for ETS2 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for ETS2 gene (2 alternative transcripts): 
    NM_001256295.1  NM_005239.5  

    Unigene Cluster for ETS2:

    V-ets erythroblastosis virus E26 oncogene homolog 2 (avian)
    Hs.644231  [show with all ESTs]
    Unigene Representative Sequence: NM_001256295
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000360214(uc002yxf.3) ENST00000360938(uc002yxg.3) ENST00000432278
    ENST00000456966

    miRNA
    Products:             		 OriGene 3'-UTR Clone: ETS2
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat ETS2
    8/49 QIAGEN miScript miRNA Assays for microRNAs that regulate ETS2 (see all 49):
    hsa-miR-607 hsa-miR-429 hsa-miR-300 hsa-miR-605 hsa-miR-1260b hsa-miR-507 hsa-miR-3921 hsa-miR-570
    SwitchGear 3'UTR luciferase reporter plasmid: ETS2 3' UTR sequence
    Inhib. RNA
    Products:             		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for ETS2 (see all 7)
    OriGene shRNA RFP: ETS2
    OriGene siRNA: ETS2
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ETS2
    Clone
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    Primer
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    Additional cDNA sequence: 

    AK000535.1 AK096841.1 AK315563.1 BC017040.1 BC042954.2 BT006838.1 J04102.1 M11922.1 

    22 DOTS entries:

    DT.219182  DT.97769195  DT.95160856  DT.100882674  DT.70103366  DT.91743735  DT.100882668  DT.91943112 
    DT.95160842  DT.99973753  DT.100703665  DT.100882693  DT.100882694  DT.121136434  DT.40107483  DT.95160841 
    DT.95186047  DT.95252128  DT.100668345  DT.92446739  DT.95272179  DT.95290582 

    24/513 AceView cDNA sequences (see all 513):

    BM023098 CD365380 BM924400 AL599156 AI268822 AA923572 BQ218344 BP363755 
    BF988026 AA055500 BF062721 AW572974 BP340805 AI094986 CB269392 CR608636 
    BM844914 AW611577 AV719693 AW469111 BP341128 AU279994 BX281368 AI921359 

    GeneLoc Exon Structure

    5/7 Alternative Splicing Database (ASD) splice patterns (SP) for ETS2 (see all 7)    About this scheme

    ExUns: 1a · 1b · 1c ^ 2a · 2b · 2c ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8a · 8b · 8c ^ 9 ^ 10a · 10b ^ 11 ^ 12 ^ 13 ^ 14a · 14b
    SP1:                    -     -           -     -                                                                                             
    SP2:                                      -     -                                                                                             
    SP3:                                                                                                                                          
    SP4:              -     -     -     -     -     -                                                                                             
    SP5:                                                                    -     -                                                               


    ECgene alternative splicing isoforms for ETS2

    Expression
    for ETS2 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    ETS2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: GTAATAAACA

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    ETS2 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    3 LifeMap In Vivo Development Anatomical Compartments/Cells 
    Tissue Anatomical Compartment CellCategory (developmental path)
    PlacentaChorion FrondosumPrimitive Cytotrophoblast CellsExtraembryonic Tissues, Placenta
    TrophoblastExtraembryonic EctodermExtraembryonic Ectoderm CellsExtraembryonic Tissues, Placenta
    TrophoblastTrophoblastTrophoblast CellsExtraembryonic Tissues
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization
    Stem Cell Differentiation: 1 LifeMap Cell 
    NameCategory
    Midbrain dopaminergic-like neurons (Generation of midbra...)

    See ETS2 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for ETS2

    SOURCE GeneReport for Unigene cluster: Hs.644231
        SABiosciences Expression via Pathway-Focused PCR Arrays including ETS2: 
              WNT Signaling Targets in human mouse rat
              Cancer PathwayFinder in human mouse rat
              Cellular Senescence in human mouse rat
              Transcription Factors in human mouse rat
              MAP Kinase (MAPK) Signaling Pathway in human mouse rat

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    In Situ
    Assay Products:     
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ETS2

    Orthologs
    for ETS2 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of animals.

    Orthologs for ETS2 gene from 6/20 species (see all 20)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves ETS21 v-ets erythroblastosis virus E26 oncogene homolog 2 more 76.4(n)
    79.53(a)    		   396250  NM_205312.1  NP_990643.1 
    lizard
    (Anolis carolinensis)    		 Reptilia ETS26
    		 --
    		 77(a)
    		 1 ↔ 1
    		 3(140003326-140017857)
    African clawed frog
    (Xenopus laevis)    		 Amphibia ets2a-A2 ets-2a proto-oncogene 76.45(n)    M81683.1 
    zebrafish
    (Danio rerio)    		 Actinopterygii ets21 v-ets erythroblastosis virus E26 oncogene homolog 2 more 64.33(n)
    62.15(a)    		   326672  NM_001023580.1  NP_001018874.1 
    fruit fly
    (Drosophila melanogaster)    		 Insecta pnt3 anti-apoptosis type II transforming growth
    factor-beta more    		 84(a)     --
    worm
    (Caenorhabditis elegans)    		 Secernentea ets-86
    ets-76
    (see all 3)    		 Protein ETS-7
    (see all 3)    		 18(a)
    16(a)
    (see all 3)    		 possible ortholog
    possible ortholog
    (see all 3)    		 IV(1159637-1161545)
    V(7557738-7558764)


    ENSEMBL Gene Tree for ETS2 (if available)
    TreeFam Gene Tree for ETS2 (if available) 

    Paralogs
    for ETS2 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for ETS2 gene
    ELK42  ETV12  ETV32  ERF2  ETV52  ETV3L2  ETS12  GABPA2  
    ERG2  ELK12  FEV2  ETV42  ETV22  FLI12  ELK32  
    2 SIMAP similar genes for ETS2 using alignment to 2 protein entries:     ETS2_HUMAN (see all proteins):
    FEV    ETS1

    ETS2 for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for ETS2
    PGOHUM00000241561


    Genomic Variants
    for ETS2 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/440 NCBI SNPs in ETS2 are shown (see all 440)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 21 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs1928805661,2
    		--40175376(+) ACCCTC/GATATT 1 -- us2k10--------
    rs1142445671,2
    		C,F,--40175621(+) CTCTGC/TCATTT 1 -- us2k11Minor allele frequency- T:0.05WA 118
    rs119113691,2
    		C,F,H,--40175634(+) TCTTCC/TGGCCG 1 -- us2k1 tfbs36Minor allele frequency- T:0.21NA CSA WA EA 365
    rs1442713941,2
    		--40175676(+) AACCCA/GCGAGG 1 -- us2k10--------
    rs355484321,2
    		C--40175690(+) AGGAC-/TTTTTT 1 -- us2k11Minor allele frequency- T:0.00NA 2
    rs1147495381,2
    		C,F,--40175773(+) AAGATT/CCTTAA 2 -- us2k11Minor allele frequency- C:0.04WA 118
    rs12099521,2
    		C,F,H,--40175827(+) TCTAAT/CATATT 2 -- us2k1118Minor allele frequency- C:0.42NS MN EA NA PA EU CA WA CSA 7298
    rs1838444581,2
    		--40175841(+) CACATG/TTGGTT 2 -- us2k10--------
    rs1869194501,2
    		--40175946(+) ACTGTC/TGGGAA 2 -- us2k10--------
    rs1173334721,2
    		F,--40175954(+) GAACCG/AGTGGT 2 -- us2k11Minor allele frequency- A:0.03EA 120

    HapMap Linkage Disequilibrium report for ETS2 (40177231 - 40196879 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for ETS2: --

    SABiosciences Cancer Mutation PCR Assays
    2 SABiosciences qBiomarker Copy Number PCR Arrays containing ETS2:
    Oncogenes & Tumor Suppressor Genes 384HC
    Prostate Cancer
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing ETS2
    DNA2.0 Custom Variant and Variant Library Synthesis for ETS2

    Disorders / Diseases
    for ETS2 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    ETS2 for disorders           About GeneDecksing

    OMIM gene information: 164740    OMIM disorders: --

    20/40 diseases for ETS2 (see all 40):    About MalaCards
    amyotrophic lateral sclerosis    frey syndrome    horner's syndrome    lateral sclerosis
    esophageal squamous cell carcinoma    squamous cell carcinoma    megakaryocytic leukemia    rheumatoid arthritis
    down syndrome    chronic myeloid leukemia    myeloid leukemia    colonic neoplasm
    choriocarcinoma    chordoma    pulmonary fibrosis    hepatocellular carcinoma
    pandas    carcinoma    ovarian cancer    breast carcinoma

    3 diseases from the University of Copenhagen DISEASES database for ETS2:
    Down syndrome     Frey Syndrome     Cancer

    10/20 Novoseek disease relationships for ETS2 gene (see all 20)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    erythroblastosis 75.2 5 2149958 (1), 17921261 (1), 12532432 (1), 16395289 (1) (see all 5)
    choriocarcinoma 60.9 11 12511603 (2), 15637148 (2), 11689681 (1)
    down syndrome 53.3 19 8596630 (3), 9918849 (2), 2149958 (1), 9315229 (1) (see all 10)
    leukemia 25.8 4 2149958 (1), 2189104 (1), 18958307 (1), 2250910 (1)
    breast cancer 15.4 12 16380248 (2), 15806151 (2), 12628005 (1), 15788656 (1) (see all 9)
    tumors 12.8 21 16240325 (4), 2149958 (2), 9605774 (2), 20145133 (2) (see all 11)
    breast carcinoma 9.84 4 14990565 (1), 16380248 (1), 9500466 (1), 15387369 (1)
    necrosis 5.09 1 16142752 (1)
    carcinoma squamous cell 0 2 12532432 (2)
    chromosomal aberrations 0 1 2149958 (1)

    Human Genome Epidemiology (HuGE) Navigator: ETS2 (5 documents)
    Tumor Gene Database (TGDB): ETS2

    Export disorders for ETS2 gene to outside databases

    Publications
    for ETS2 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for ETS2 gene, integrated from 9 sources (see all 228):
    (articles sorted by number of sources associating them with ETS2)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Molecular organization and differential polyadenylation sites of the human ETS2 gene. (PubMed id 2250910)1, 2, 9 Watson D.K....Papas T.S. (1990)
    2. Transcriptional regulation of telomerase activity: roles of the the Ets transcription factor family. (PubMed id 17986575)1, 3 Dwyer J....Liu J.P. (2007)
    3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    5. The DNA sequence of human chromosome 21. (PubMed id 10830953)1, 2 Hattori M....Yaspo M.L. (2000)
    6. Mammalian ets-1 and ets-2 genes encode highly conserved proteins. (PubMed id 2847145)1, 2 Watson D.K.... Papas T.S. (1988)
    7. The ets sequence from the transforming gene of avian erythroblastosis virus, E26, has unique domains on human chromosomes 11 and 21: both loci are transcriptionally active. (PubMed id 2997781)1, 2 Watson D.K.... Papas T.S. (1985)
    8. CD13/APN transcription is induced by RAS/MAPK-mediated phosphorylation of Ets-2 in activated endothelial cells. (PubMed id 14507917)1, 9 Petrovic N....Shapiro L.H. (2003)
    9. Overexpression of ETS2 in human esophageal squamous cell carcinoma. (PubMed id 12532432)1, 9 Li X....Liu Z.H. (2003)
    10. A central role for Ets-2 in the transcriptional regulation and cyclic adenosine 5'-monophosphate responsiveness of the human chorionic gonadotropin-beta subunit gene. (PubMed id 12511603)1, 9 Ghosh D....Roberts R.M. (2003)

    External Searches for ETS2 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing ETS2 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 2114 HGNC: 3489 AceView: ETS2 Ensembl:ENSG00000157557 euGenes: HUgn2114
    ECgene: ETS2 Kegg: 2114 H-InvDB: ETS2

    Other Databases showing ETS2 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing ETS2 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for ETS2 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for ETS2 Genetics and Cytogenetics in Oncology and Haematology

    Intellectual Property
    for ETS2 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for ETS2 gene:
    Search GeneIP for patents involving ETS2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    Products
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    About This Section

     
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