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ETS2 Gene

protein-coding   GIFtS: 65
GCID: GC21P040177

V-Ets Avian Erythroblastosis Virus E26 Oncogene Homolog...

(Previous name: v-ets erythroblastosis virus E26 oncogene homolog 2 (avian))
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, 15RNAdb, and/or 11Nature:405,311-319 and CroW21)
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Aliases
V-Ets Avian Erythroblastosis Virus E26 Oncogene Homolog 21 2     Oncogene ETS-22
V-Ets Erythroblastosis Virus E26 Oncogene Homolog 2 (Avian)1     Protein C-Ets-22
Human Erythroblastosis Virus Oncogene Homolog 211     V-Ets Avian Erythroblastosis Virus E2 Oncogene Homolog 22
ETS2IT12     V-Ets Erythroblastosis Virus E26 Oncogene Homolog 22

External Ids:    HGNC: 34891   Entrez Gene: 21142   Ensembl: ENSG000001575577   OMIM: 1647405   UniProtKB: P150363   

Export aliases for ETS2 gene to outside databases

Previous GC identifers: GC21P036755 GC21P039097 GC21P039098 GC21P039099 GC21P025647


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for ETS2 Gene:
This gene encodes a transcription factor which regulates genes involved in development and apoptosis. The encoded
protein is also a protooncogene and shown to be involved in regulation of telomerase. A pseudogene of this gene
is located on the X chromosome. Alternative splicing results in multiple transcript variants. (provided by
RefSeq, Jan 2012)

GeneCards Summary for ETS2 Gene:
ETS2 (v-ets avian erythroblastosis virus E26 oncogene homolog 2) is a protein-coding gene. Diseases associated with ETS2 include frey syndrome, and horner's syndrome. GO annotations related to this gene include glucocorticoid receptor binding and sequence-specific DNA binding transcription factor activity. An important paralog of this gene is ETV1.

UniProtKB/Swiss-Prot: ETS2_HUMAN, P15036
Function: Transcription factor activating transcription. Binds specifically the DNA GGAA/T core motif (Ets-binding
site or EBS) in gene promoters and stimulates transcription

Gene Wiki entry for ETS2 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics, Whole Chromsome Sequence According to Nature (Cited Here with Permission):405,311-319 and CroW21)
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RefSeq DNA sequence:
NC_000021.9  NT_011512.12  NC_018932.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the ETS2 gene promoter:
         GR   C/EBPbeta   p53   GR-beta   GATA-1   CREB   deltaCREB   GR-alpha   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 4): ETS2 promoter sequence

   Search Chromatin IP Primers for ETS2

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ETS2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 21q22.2   Ensembl cytogenetic band:  21q22.2   HGNC cytogenetic band: 21q22.3
Nature(405: 311-319) cytogenetic band:   21q22.2
ETS2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ETS2 gene location
GeneLoc information about chromosome 21         GeneLoc Exon Structure

(about GC identifiers)
GC21P040177:   GeneLoc Nature:405,311-319
Start:
40,177,231 bp from pter       25,754,197 bp from centromere
End:
40,196,879 bp from pter 25,771,822 bp from centromere
Size:
19,649 bases 17,626 bases
Orientation:
plus strand plus strand

Whole chromosome sequencing:
cDNA sequence: J04102
genomic clones: Q109A8 KUD94C10


(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: ETS2_HUMAN, P15036 (See protein sequence)
Recommended Name: Protein C-ets-2  
Size: 469 amino acids; 53001 Da
2 PDB 3D structures from and Proteopedia for ETS2:
4BQA (3D)        4MHV (3D)    
Secondary accessions: A6NM68 D3DSH6 Q53Y89

Explore the universe of human proteins at neXtProt for ETS2: NX_P15036

Explore proteomics data for ETS2 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys427
  • Modification sites at PhosphoSitePlus

  • See ETS2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001243224.1  NP_005230.1  

    ENSEMBL proteins: 
     ENSP00000353344   ENSP00000354194   ENSP00000401273   ENSP00000411086  
    Reactome Protein details: P15036

    ETS2 Human Recombinant Protein Products:

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    Novus Biologicals ETS2 Lysates
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    Browse Sino Biological Cell Lysates
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    Cloud-Clone Corp. Proteins for ETS2

    ETS2 Antibody Products:

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    LSBio Antibodies in human, mouse, rat for ETS2

    ETS2 Assay Products:

    Browse Kits and Assays available from EMD Millipore
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    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for ETS2
    Cloud-Clone Corp. CLIAs for ETS2


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    Selected InterPro protein domains (see all 6):
     IPR016311 Transform_prot_C-ets
     IPR000418 Ets_dom
     IPR027276 Transform_prot_C-ets-2
     IPR011991 WHTH_DNA-bd_dom
     IPR003118 Pointed_dom

    Graphical View of Domain Structure for InterPro Entry P15036

    ProtoNet protein and cluster: P15036

    1 Blocks protein domain: IPB003118 Sterile alpha motif (SAM)/Pointed domain

    UniProtKB/Swiss-Prot: ETS2_HUMAN, P15036
    Similarity: Belongs to the ETS family
    Similarity: Contains 1 ETS DNA-binding domain
    Similarity: Contains 1 PNT (pointed) domain


    ETS2 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ETS2_HUMAN, P15036
    Function: Transcription factor activating transcription. Binds specifically the DNA GGAA/T core motif (Ets-binding
    site or EBS) in gene promoters and stimulates transcription

         Genatlas biochemistry entry for ETS2:
    avian erythroblastosis virus E26 (v-ets) oncogene homolog 2,activating stromelysin-1 (MMP3) and collagenase 1
    (MMP8) promoters,likely involved in skeletal development,required to maintain the transformed state of human
    prostate cancer cells

         Gene Ontology (GO): Selected molecular function terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000977RNA polymerase II regulatory region sequence-specific DNA binding IEA--
    GO:0000981sequence-specific DNA binding RNA polymerase II transcription factor activity IBA--
    GO:0003677DNA binding TAS10918595
    GO:0003700sequence-specific DNA binding transcription factor activity IDA11909962
    GO:0005515protein binding IPI11909962
         
    ETS2 for ontologies           About GeneDecksing


    Phenotypes:
         9 MGI mutant phenotypes (inferred from 6 alleles(MGI details for Ets2):
     cardiovascular system  embryogenesis  endocrine/exocrine gland  growth/size/body  homeostasis/metabolism 
     integument  mortality/aging  normal  tumorigenesis 

    ETS2 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-outs for ETS2: Ets2tm5.2Rgo Ets2tm1Rgo Ets2tm3.1Rgo

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for ETS2
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for ETS2

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for ETS2
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for ETS2

    miRNA
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    miRTarBase miRNAs that target ETS2:
    hsa-mir-218-5p (MIRT024245), hsa-mir-18a-5p (MIRT050649), hsa-mir-149-5p (MIRT045544), hsa-mir-199a-3p (MIRT000775), hsa-mir-877-5p (MIRT037225), hsa-mir-199a-5p (MIRT004398)

    Block miRNA regulation of human, mouse, rat ETS2 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate ETS2 (see all 49):
    hsa-miR-607 hsa-miR-429 hsa-miR-300 hsa-miR-605 hsa-miR-1260b hsa-miR-507 hsa-miR-3921 hsa-miR-570
    SwitchGear 3'UTR luciferase reporter plasmidETS2 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for ETS2
    Predesigned siRNA for gene silencing in human, mouse, rat ETS2

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for ETS2

    Clone
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    OriGene clones in human, mouse for ETS2 (see all 7)
    OriGene ORF clones in mouse, rat for ETS2
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: ETS2 (NM_005239)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for ETS2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ETS2

    Cell Line
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    Browse ESI BIO Cell Lines and PureStem Progenitors for ETS2 
    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ETS2


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    ETS2_HUMAN, P15036: Nucleus
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    cytosol1
    extracellular1

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA16780588
    GO:0005654nucleoplasm TAS--

    ETS2 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for ETS2 About   (see all 13)  
    See pathways by source

    SuperPathContained pathways About
    1Cellular Senescence
    Cellular Senescence0.81
    Cellular responses to stress0.81
    2ERK Signaling
    ERK Signaling0.61
    3CNTF Signaling
    Nur77-Induced AICD in Macrophage0.45
    4Myometrial Relaxation and Contraction Pathways
    Myometrial Relaxation and Contraction Pathways0.43
    5Ras signaling pathway
    Ras signaling pathway0.36

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    Selected Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for ETS2 (see all 6)
        Nur77-Induced AICD in Macrophage
    ERK Signaling
    HGF Pathway
    Oct4 in Mammalian ESC Pluripotency
    MIF Action Through Endocytic Pathway

    2 BioSystems Pathways for ETS2
        Myometrial Relaxation and Contraction Pathways
    C-MYB transcription factor network

    1 Reactome Pathway for ETS2
        Oncogene Induced Senescence


    3 Kegg Pathways  (Kegg details for ETS2):
        Ras signaling pathway
    Dorso-ventral axis formation
    HTLV-I infection


    ETS2 for pathways           About GeneDecksing

        Pathway & Disease-focused RT2 Profiler PCR Arrays including ETS2: 
              WNT Signaling Targets in human mouse rat
              Cancer PathwayFinder in human mouse rat
              Cellular Senescence in human mouse rat
              Transcription Factors in human mouse rat
              MAP Kinase (MAPK) Signaling Pathway in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for ETS2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for ETS2 (P150361, 2, 3 ENSP000003533444) via UniProtKB, MINT, STRING, and/or I2D (see all 96)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ZFYVE9O954052, 3MINT-62043 I2D: score=3 
    POU5F1Q018603, ENSP000002599154I2D: score=2 STRING: ENSP00000259915
    ENSG00000206454Q018603I2D: score=2 
    ENSG00000229094Q018603I2D: score=2 
    ENSG00000230336Q018603I2D: score=2 
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001501skeletal system development TAS8596630
    GO:0006351transcription, DNA-templated ----
    GO:0006355regulation of transcription, DNA-templated ----
    GO:0006357regulation of transcription from RNA polymerase II promoter IBA--
    GO:0006366transcription from RNA polymerase II promoter IBA--

    ETS2 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for ETS2

    Selected Novoseek inferred chemical compound relationships for ETS2 gene (see all 11)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    oligonucleotide 27 1 15314206 (1)
    phorbol 20.1 2 10454570 (1), 16909100 (1)
    pd 98,059 19.2 1 12511603 (1)
    threonine 8.98 6 8552081 (4), 12511603 (1)
    matrigel 7.19 2 9500466 (1), 11114728 (1)
    agar 5.96 3 9500466 (2), 2149958 (1)
    steroid 0 1 14722092 (1)
    superoxide 0 3 2045100 (1), 9918849 (1), 1347193 (1)
    alanine 0 2 8552081 (2)
    estrogen 0 1 1347193 (1)



    ETS2 for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for ETS2 gene (2 alternative transcripts): 
    NM_001256295.1  NM_005239.5  

    Unigene Cluster for ETS2:

    V-ets erythroblastosis virus E26 oncogene homolog 2 (avian)
    Hs.644231  [show with all ESTs]
    Unigene Representative Sequence: NM_001256295
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000360214(uc002yxf.3) ENST00000360938(uc002yxg.3) ENST00000432278
    ENST00000456966
    miRNA
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    Selected qRT-PCR Assays for microRNAs that regulate ETS2 (see all 49):
    hsa-miR-607 hsa-miR-429 hsa-miR-300 hsa-miR-605 hsa-miR-1260b hsa-miR-507 hsa-miR-3921 hsa-miR-570
    SwitchGear 3'UTR luciferase reporter plasmidETS2 3' UTR sequence
    Inhib. RNA
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    GenScript: all cDNA clones in your preferred vector: ETS2 (NM_005239)
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    Primer
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    OriGene qPCR primer pairs and template standards for ETS2
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    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat ETS2
      QuantiTect SYBR Green Assays in human, mouse, rat ETS2
      QuantiFast Probe-based Assays in human, mouse, rat ETS2

    Additional mRNA sequence: 

    AK000535.1 AK096841.1 AK315563.1 BC017040.1 BC042954.2 BT006838.1 J04102.1 M11922.1 

    22 DOTS entries:

    DT.219182  DT.97769195  DT.95160856  DT.100882674  DT.70103366  DT.91743735  DT.100882694  DT.100882668 
    DT.91943112  DT.95160842  DT.99973753  DT.100703665  DT.100882693  DT.121136434  DT.40107483  DT.95160841 
    DT.95186047  DT.95252128  DT.100668345  DT.92446739  DT.95272179  DT.95290582 

    Selected AceView cDNA sequences (see all 513):

    AI859056 F03396 AI587436 BQ002471 AV655540 BM805527 BC017040 BG698877 
    AI094986 BF940784 NM_005239 AI921359 AA055499 BP363755 CB529855 BM353061 
    AI423414 BG259639 AW192175 AW272847 BF062721 AA923572 BP340805 BQ436974 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for ETS2 (see all 7)    About this scheme

    ExUns: 1a · 1b · 1c ^ 2a · 2b · 2c ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8a · 8b · 8c ^ 9 ^ 10a · 10b ^ 11 ^ 12 ^ 13 ^ 14a · 14b
    SP1:                    -     -           -     -                                                                                             
    SP2:                                      -     -                                                                                             
    SP3:                                                                                                                                          
    SP4:              -     -     -     -     -     -                                                                                             
    SP5:                                                                    -     -                                                               


    ECgene alternative splicing isoforms for ETS2

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

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    ETS2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GTAATAAACA
    ETS2 Expression
    About this image


    ETS2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 6) fully expand
     
     Placenta (Extraembryonic Tissues)
             Primitive Cytotrophoblast Cells Chorion Frondosum
     
     Blood (Hematopoietic System)    fully expand to see all 3 entries
             Monocytes Peripheral Blood
             Umbilical cord blood-derived hematopoietic stem cells
     
     Trophoblast (Extraembryonic Tissues)    fully expand to see all 2 entries
             Trophoblast Cells Trophoblast
     
     Umbilical Cord (Extraembryonic Tissues)    fully expand to see all 2 entries
             Umbilical cord blood-derived hematopoietic stem cells
     
     Bone (Muscoskeletal System)
             Membranous Facial Bones
    ETS2 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    ETS2 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.644231
        Pathway & Disease-focused RT2 Profiler PCR Arrays including ETS2: 
              WNT Signaling Targets in human mouse rat
              Cancer PathwayFinder in human mouse rat
              Cellular Senescence in human mouse rat
              Transcription Factors in human mouse rat
              MAP Kinase (MAPK) Signaling Pathway in human mouse rat

    Primer
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    OriGene qPCR primer pairs and template standards for ETS2
    OriGene qSTAR qPCR primer pairs in human, mouse for ETS2
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat ETS2
    QuantiTect SYBR Green Assays in human, mouse, rat ETS2
    QuantiFast Probe-based Assays in human, mouse, rat ETS2
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ETS2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for ETS2 gene from Selected species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Ets21 , 5 E26 avian leukemia oncogene 2, 3' domain1, 5 85.94(n)1
    91.86(a)1
      16 (56.64 cM)5
    238721  NM_011809.31  NP_035939.31 
     957020755 
    chicken
    (Gallus gallus)
    Aves ETS21 v-ets erythroblastosis virus E26 oncogene homolog 2 76.33(n)
    79.53(a)
      396250  NM_205312.1  NP_990643.1 
    lizard
    (Anolis carolinensis)
    Reptilia ETS26
    v-ets avian erythroblastosis virus E26 oncogene ho...
    77(a)
    1 ↔ 1
    3(140000013-140023723)
    African clawed frog
    (Xenopus laevis)
    Amphibia ets2a-A2 ets-2a proto-oncogene 76.45(n)    M81683.1 
    zebrafish
    (Danio rerio)
    Actinopterygii ets21 v-ets erythroblastosis virus E26 oncogene homolog 2 more 64.56(n)
    62.15(a)
      326672  NM_001023580.1  NP_001018874.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta pnt3 anti-apoptosis type II transforming
    growth factor-beta more
    84(a)     --


    ENSEMBL Gene Tree for ETS2 (if available)
    TreeFam Gene Tree for ETS2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for ETS2 gene
    ETV12  ETV32  ERF2  ETV52  ETV3L2  ETS12  GABPA2  ERG2  
    FEV2  ETV42  ETV22  FLI12  
    2 SIMAP similar genes for ETS2 using alignment to 2 protein entries:     ETS2_HUMAN (see all proteins):
    FEV    ETS1

    ETS2 for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for ETS2
    PGOHUM00000241561


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for ETS2 (see all 540)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 21 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1928805661,2
    --40175376(+) ACCCTC/GATATT 1 -- us2k10--------
    rs1142445671,2
    C,F--40175621(+) CTCTGC/TCATTT 1 -- us2k11Minor allele frequency- T:0.05WA 118
    rs119113691,2
    C,F,H--40175634(+) TCTTCC/TGGCCG 1 -- us2k1 tfbs36Minor allele frequency- T:0.21NA CSA WA EA 365
    rs1442713941,2
    C--40175676(+) AACCCA/GCGAGG 1 -- us2k10--------
    rs355484321,2
    C--40175690(+) AGGAC-/TTTTTT 1 -- us2k11Minor allele frequency- T:0.00NA 2
    rs1147495381,2
    C,F--40175773(+) AAGATT/CCTTAA 2 -- us2k11Minor allele frequency- C:0.04WA 118
    rs12099521,2
    C,F,H--40175827(+) TCTAAT/CATATT 2 -- us2k1118Minor allele frequency- C:0.42NS MN EA NA PA EU CA WA CSA 7298
    rs1838444581,2
    C--40175841(+) CACATG/TTGGTT 2 -- us2k10--------
    rs1869194501,2
    --40175946(+) ACTGTC/TGGGAA 2 -- us2k10--------
    rs1173334721,2
    F--40175954(+) GAACCG/AGTGGT 2 -- us2k11Minor allele frequency- A:0.03EA 120

    HapMap Linkage Disequilibrium report for ETS2 (40177231 - 40196879 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for ETS2:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv3518CNV Insertion18451855

    Site Specific Mutation Identification with PCR Assays
    2 Copy Number PCR Panels containing ETS2:
    Oncogenes & Tumor Suppressor Genes 384HC
    Prostate Cancer
    SeqTarget long-range PCR primers for resequencing ETS2
    DNA2.0 Custom Variant and Variant Library Synthesis for ETS2

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 164740    OMIM disorders: --

    Selected diseases for ETS2 (see all 36):    
    About MalaCards
    frey syndrome    horner's syndrome    pandas    megakaryocytic leukemia
    chordoma    down syndrome    choriocarcinoma    conjunctivitis
    chronic myeloid leukemia    labyrinthitis    lung adenocarcinoma    esophageal squamous cell carcinoma
    hepatocellular carcinoma    lateral sclerosis    amyotrophic lateral sclerosis    pulmonary fibrosis
    ovarian cancer    prostate cancer    rheumatoid arthritis    hepatitis b

    3 diseases from the University of Copenhagen DISEASES database for ETS2:
    Frey Syndrome     Down syndrome     Cancer

    ETS2 for disorders           About GeneDecksing

    Selected Novoseek inferred disease relationships for ETS2 gene (see all 20)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    erythroblastosis 75.2 5 2149958 (1), 17921261 (1), 12532432 (1), 16395289 (1) (see all 5)
    choriocarcinoma 60.9 11 12511603 (2), 15637148 (2), 11689681 (1)
    down syndrome 53.3 19 8596630 (3), 9918849 (2), 2149958 (1), 9315229 (1) (see all 10)
    leukemia 25.8 4 2149958 (1), 2189104 (1), 18958307 (1), 2250910 (1)
    breast cancer 15.4 12 16380248 (2), 15806151 (2), 12628005 (1), 15788656 (1) (see all 9)
    tumors 12.8 21 16240325 (4), 2149958 (2), 9605774 (2), 20145133 (2) (see all 11)
    breast carcinoma 9.84 4 14990565 (1), 16380248 (1), 9500466 (1), 15387369 (1)
    necrosis 5.09 1 16142752 (1)
    carcinoma squamous cell 0 2 12532432 (2)
    chromosomal aberrations 0 1 2149958 (1)

    Genetic Association Database (GAD): ETS2
    Human Genome Epidemiology (HuGE) Navigator: ETS2 (5 documents)
    Tumor Gene Database (TGDB): ETS2

    Export disorders for ETS2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for ETS2 gene, integrated from 10 sources (see all 240):
    (articles sorted by number of sources associating them with ETS2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Molecular organization and differential polyadenylation sites of the human ETS2 gene. (PubMed id 2250910)1, 2, 9 Watson D.K....Papas T.S. (Oncogene 1990)
    2. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (Mol. Med. 2010)
    3. High-density association study of 383 candidate genes for volumetric BMD at the femoral neck and lumbar spine among older men. (PubMed id 19453261)1, 4 Yerges L.M....Zmuda J.M. (J. Bone Miner. Res. 2009)
    4. Transcriptional regulation of telomerase activity: roles of the the Ets transcription factor family. (PubMed id 17986575)1, 3 Dwyer J....Liu J.P. (Ann. N. Y. Acad. Sci. 2007)
    5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    6. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    7. Sp100 interacts with ETS-1 and stimulates its transcriptional activity. (PubMed id 11909962)1, 2 Wasylyk C.... Wasylyk B. (Mol. Cell. Biol. 2002)
    8. The DNA sequence of human chromosome 21. (PubMed id 10830953)1, 2 Hattori M.... Yaspo M.-L. (Nature 2000)
    9. Mammalian ets-1 and ets-2 genes encode highly conserved proteins. (PubMed id 2847145)1, 2 Watson D.K.... Papas T.S. (Proc. Natl. Acad. Sci. U.S.A. 1988)
    10. The ets sequence from the transforming gene of avian erythroblastosis virus, E26, has unique domains on human chromosomes 11 and 21: both loci are transcriptionally active. (PubMed id 2997781)1, 2 Watson D.K.... Papas T.S. (Proc. Natl. Acad. Sci. U.S.A. 1985)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 2114 HGNC: 3489 AceView: ETS2 Ensembl:ENSG00000157557 euGenes: HUgn2114
    ECgene: ETS2 Kegg: 2114 H-InvDB: ETS2

    (According to HUGE)
    About This Section

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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for ETS2 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for ETS2 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for ETS2 gene:
    Search GeneIP for patents involving ETS2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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